CN107157881A - Composition and cosmetics with acne-removing - Google Patents
Composition and cosmetics with acne-removing Download PDFInfo
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- CN107157881A CN107157881A CN201710382604.0A CN201710382604A CN107157881A CN 107157881 A CN107157881 A CN 107157881A CN 201710382604 A CN201710382604 A CN 201710382604A CN 107157881 A CN107157881 A CN 107157881A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention discloses a kind of composition and cosmetics with acne-removing；One kind is aimed to provide to be made up of natural plant composition, by adjusting sebum secretion, anti-inflammation, Rose Extract, the composition of small pox skin is effectively solved the problems, such as, said composition includes youthwort extract, logwood extract, willowherb extract, iris root extract；The invention also discloses the cosmetics of the composition containing this with acne-removing, including facial treatment essence, skin care creams and face cleaning gel, belong to cosmetic technical field.
Description
Technical field
The present invention relates to a kind of composition and cosmetics with acne-removing, more particularly to one kind is carried containing youthwort
The composition with acne-removing of thing, logwood extract, willowherb extract, iris root extract is taken, and includes the combination
The cosmetics of thing, belong to cosmetic technical field.
Background technology
Acne, also known as whelk, acne, dark sore, acne etc., it is the common hair caused by one kind of multiple combined factors effects
Capsule, sebaceous glands chronic inflammatory diseases.80% young man can run into serious or slight acne problems in puberty.Although,
Most people thinks that acne is a kind of cutaneous disorder disease, and then, these defects are not that teenager is exclusive, and 20% adult is also
With so-called " sending out acne afterwards ".Acne is clinical with the characteristics of face and chest and back are dispersed in the skin disease for occurring needle point grain of rice size,
Or see blackhead, granulated slag sample thing, rash and useless fellow in first meeting such as tiny mound, with tubercle, tumour, scar, color when serious can be sent
It is plain calm.Therefore, acne is undoubtedly a kind of most bothersome disease of skin, and in addition to its visible marks, it may also draw
Send out mood some or the problem of psychology, cause to live to patient, work and social activity in terms of puzzlement.
Acne be due to sebum hair follicle it is infected caused by.Sebum hair follicle is hair growth place, while being also sebum
The place of glandular secretion product storage.Hair follicle is the ground of the generation of following three kinds of phenomenons：Excessive sebum secretion, sebum conduit cutin
Change, hair follicle inflammation.
The first factor：Excessive sebum secretion is that often have phenomenon.Sebum secretion and hormone secretion tight association, it is especially male
Hormone.Under the influence of 5- 5 alpha-reductases, free testosterone is converted into active double hydrogen testosterones（ DHT）.
This hormone makes sebum hylperadenosis and the increase of sebum secretion product.
Second of factor：Sebum conduit keratinization.Sebum conduit is gradually filled by sebum and dead cell, until it is blocked completely
Plug.So form blackhead and hoary hair.
The third factor：Bacterium in sebum conduit bottom（Propionibacterium acnes）Grown using favourable oxygen-free environment numerous
Grow.These bacteriums decompose the sebum gathered, discharge aliphatic acid that is excitatory and changing sebum tube wall, thus cause inflammation anti-
Should.So, blackhead then becomes the papule of inflammation, is led to red and swollen and irritates.
At present, the treatment to whelk is usual by taking micro-element, endocrine preparation and antibiotic orally, and outer wiping cream etc. is done
Method, but effect is not ideal enough, causes whelk flickering, repeated.
The content of the invention
For above-mentioned deficiency, it is an object of the present invention to provide a kind of composition with acne-removing, the combination
Thing is main by a variety of natural plant composition youthwort extracts, logwood extract, willowherb extract, iris root extract group
Into small pox skin effectively can be solved the problems, such as by adjusting sebum secretion, anti-inflammation, Rose Extract.
Another object of the present invention is to be to provide a kind of cosmetics of the composition containing above-mentioned acne-removing, the cosmetic
Product may be directly applied to human skin, nursing skin, the effect with effective anti-acne.
Therefore, first technical scheme that the present invention is provided is a kind of composition with acne-removing, said composition bag
Include youthwort extract, logwood extract, willowherb extract, iris root extract；Wherein, the youthwort is extracted
Thing, logwood extract, willowherb extract, orrisroot extract quality ratio are the ﹕ 2 of 65 ﹕ of ﹕ 4-6 ﹕ 2-4 ﹕ 1-3, preferably 6 ﹕ 3.
Above-mentioned youthwort extract, extracts from the herb of Droseraceae drosera youthwort, main
It is the naphthoquinone derivatives such as droserone, white flowers, hydrogenation plumbagin glucoside, droserone 5-O- glucosides to want composition, with
And the flavones ingredient such as Quercetin, Kaempferol.According to specific embodiments of the present invention, the group with acne-removing of the invention
In compound, the youthwort extract is extracted in accordance with the following methods to be obtained：Take youthwort herb, drying and crushing
60 mesh sieves are crossed, CO is added to2In supercritical extract device, from ethanol as entrainer, entrainer accounts for the volume of total extractant
Percentage is 1-3%, and extracting pressure 25-35Mpa, 35-45 DEG C of temperature, extraction time 1-3h extracts agent flux 25-35L/h, obtained
To extract distilled water diluting（Appropriate propane diols hydrotropy can be added）, then with 0.45 μm of membrane filtration, obtain roundleaf thatch
Cream dish extract；The extract solution is yellowish-brown liquid, mainly contains droserone and flavone compound.
Above-mentioned logwood extract, extracts from the dry duramen of pulse family Caesalpinia bush, main component be bush phenol,
Haematoxylin, tannin, flavonols etc..According to specific embodiments of the present invention, in the composition with acne-removing of the invention,
The logwood extract extracts obtain in accordance with the following methods：Bush is taken, drying and crushing is crossed after 100 mesh sieves, according to every gram of Soviet Union
The ratio of wooden 10-15mL Extraction solvents, is mixed with the ethanol of 30-60% concentration, and heating water bath is incubated 1-2h to 60-75 DEG C, receives
Collection supernatant, repeats operation 2 times above, merges supernatant and simultaneously centrifuges, and the supernatant that centrifugation is obtained carries out being concentrated under reduced pressure into nothing
Alcohol taste, then concentrate is centrifuged, filtered fluid is collected in ultrafiltration, and the albumin for adding filtrate quality 0.2-0.4% is anti-at 45-55 DEG C
20min is answered, is centrifuged, the supernatant distilled water diluting being collected into（Appropriate propane diols hydrotropy can be added）, then with 0.45 μm of filter
Membrane filtration, obtains logwood extract；The extract solution is brown color liquid, mainly contains flavone compound.
Above-mentioned willowherb extract, extracts from the herb of Oenotheraceae Epilobium plant willow herb and congener, mainly
Contain flavones, phenolic acid and tannin etc..According to specific embodiments of the present invention, the composition with acne-removing of the invention
In, the willowherb extract is extracted obtain in accordance with the following methods：Willow herb herb is taken, drying and crushing is crossed after 80 mesh sieves, according to
The ratio of every gram of willow herb 8-12mL Extraction solvent, adds the ethanol solution of 60% ~ 80% concentration, 70-80 DEG C of insulation refluxing extraction three
Secondary, each 1h merges three filtrates, and concentration removes ethanol, uses distilled water diluting（Appropriate propane diols hydrotropy can be added）, Ran Houyong
0.45 μm of membrane filtration, obtains willowherb extract, and the extract solution is dark brown liquid, mainly contains flavonoids and phenolic acid class chemical combination
Thing.
Above-mentioned iris root extract, extracts from the root-like stock of Iridaceae iris pale flag and congener,
Glucoside containing kite, iris Neogroside, irone glucoside etc..According to specific embodiments of the present invention, the group with acne-removing of the invention
In compound, the iris root extract is extracted in accordance with the following methods to be obtained：Using orrisroot as raw material, drying and crushing crosses 100
Mesh sieve, according to the ethanol of the ratio of every gram of orrisroot 5-10mL Extraction solvent, plus 80-90% concentration, ultrasound is auxiliary at 55-65 DEG C
Extraction 0.5-1h is helped, supernatant is collected by centrifugation, operation 2-3 times above is repeated, the supernatant after merging is concentrated under reduced pressure into substance
Long-pending 1/3-1/5, then isolated and purified through macroreticular resin, ethanol water gradient elution, the eluent being collected into, be concentrated under reduced pressure recovery second
Alcohol, uses distilled water diluting（Appropriate propane diols hydrotropy can be added）, then with 0.45 μm of membrane filtration, iris root extract is obtained,
The extract solution is yellowish-brown liquid, mainly contains flavone compound.
The composition with acne-removing of the present invention, comprising extracting obtained natural component, each extract from plant
Component mutually acts synergistically, can be by adjusting sebum secretion, anti-inflammation, Rose Extract and accelerating cell propagation so as to promote
Cytothesis, reaches effective effect for dispelling human body face skin small pox.
In the composition with acne-removing of the present invention, youthwort extract has good to the activity of 5 а-reductase
Good inhibitory action, can suppress the secretion of male sex hormone, so as to reduce the excessive secretion of sebum, the extract is also to gold in addition
Staphylococcus aureus, Escherichia coli and Bacillus subtilis etc. have preferable suppression；Logwood extract has good broad-spectrum antiseptic energy
Power, the MI values to propionibacterium acnes are 46.13 μ g/mL, and can also effectively suppress Escherichia coli, Pseudomonas aeruginosa and golden yellow
Staphylococcus etc., compared with conventional antiseptic, will not produce and cause allergic side effect, can also suppress in addition 5 а-also
The activity of protoenzyme, reduces the excessive secretion of sebum, and can be used for cosmetics as antiinflammatory；Willowherb extract can be removed
Free radical, suppresses staphylococcus aureus, Candida albicans, propionibacterium acnes etc., with multiple biological activities function, including
The effects such as anti-oxidant, anti-irritant, anti-acne and anti-extraordinary 3male hormone secretion；Iris root extract is rich in tectoridin, there is anti-
The effect of hyaluronidase, therefore with good antiinflammation, additionally with anti-inflammation, convergence and the work(for relaxing hyperemia
Effect.
The latter solution that the present invention is provided is to provide the cosmetics containing the above-mentioned composition with acne-removing.
A kind of cosmetics with acne-removing, the cosmetics include facial treatment essence, skin care creams and face cleaning gel.
Specifically, addition of the described composition with acne-removing in cosmetics is 0.5-6%, preferably 1-
4%, different content can be added according to the specific species difference of cosmetics.
It is preferred that, a kind of above-mentioned facial treatment essence with acne-removing, it includes each component of following percentage by weight：
Dipropylene glycol 2-6%, propane diols 1-3%, allantoin 0.1-0.2%, glycine betaine 1-3%, carbomer 0.4-0.7%, arginine 0.4-
0.7%, niacinamide 1-4%, shale oil sulphonic acid ester sodium 1.5-4%, Bacillus acidi lactici/fermented soybean product extract/butanediol 0.5-
2%, decoyl hydroximic acid 0.4-1.0%, o- cymene -5- alcohol 0.05-0.1%, the composition of the present invention with acne-removing
0.5-6%, deionized water to 100%.
In above-mentioned facial treatment essence, appropriate preservative, essence, anti-sensitizer etc. can be also added, the application of these specific compositions
And consumption and preparation method can be carried out according to the routine techniques of existing facial treatment essence.
It is preferred that, above-mentioned skin care creams with acne-removing, it includes each component of following percentage by weight：PEG-20
Methyl sesquistearate 1-3%, methyl sesquistearate 0.5-1.5%, cetostearyl alcohol 1-3%, palmitic acid is different
Propyl ester 2-4%, carbonic acid dioctyl ester 1-4%, dimethyl silicone polymer 1-4%, Queensland nut seed oil 0.5-3%, Babassu seed oil glycerine
Polyethers -8 esters 0.1-1%, bisabolol 0.05-0.2%, allantoin 0.1-0.2%, glycerine 4-8%, carbomer 0.15-0.4%,
Sodium Hyaluronate 0.01-0.1%, o- cymene -5- alcohol 0.05-0.1%, phosphoglycerol inositol choline salt 0.1-0.5%, the present invention
The described composition 0.5-6% with acne-removing, deionized water to 100%.
In above-mentioned skin care creams, can also add appropriate pH adjusting agent, preservative, essence etc., these specific compositions should
With and consumption and preparation method can be carried out according to the routine techniques of existing skin care creams.
It is preferred that, the above-mentioned face cleaning gel with acne-removing, it includes each component of following percentage by weight：EDTA
Disodium 0.05-0.15%, glycerine 4-8%, the 1-2% of polyethylene glycol -32, laureth sodium sulfovinate 9-14%, allantoin 0.1-
0.3%, coconut oleoyl amine 1-4%, lauryl glucoside/Plantacare 818 5-8%, laureth potassium phosphate 3-6%, lauramide third
Base glycine betaine 6-10%, sodium lauroyl sarcosine 3-7%, hydroxyacetic acid 0.05-0.1%, 10- hydroxydecanoic acid 0.1-0.5%, tea leaf oil
0.1-0.5%, the composition 0.5-6% of the present invention with acne-removing, deionized water to 100%.
In above-mentioned face cleaning gel, can also add appropriate pH adjusting agent, preservative, essence etc., these specific compositions should
With and consumption and preparation method can be carried out according to the routine techniques of existing face cleaning gel.
In specific production, when adding low-temperature phase, the present invention there can be into anti-acne work(according to conventional production process
The composition of effect is added in described cosmetics.The composition with acne-removing of the present invention is added to creams, elite, water
In the cosmetics such as agent, gel, mildy wash, face cleaning cream, face cleaning gel, by controlling rational addition and appropriate technique bar
Part, will not be damaged, the stability to cosmetics will not bring detrimental effect, will not cause to the composition structure of cosmetics
The quality problems such as discoloration, layering.
In summary, the invention provides a kind of composition with acne-removing, it is applied to the production of cosmetics, many
Natural plant composition synergy is planted, sebum secretion, anti-inflammation, Rose Extract is effectively adjusted, and natural extract is to skin
Skin is gentle, substantially nonirritant, and prepared skin-protection product has obvious anti-acne effect by efficacy validation.
Embodiment
The beneficial effect for describing the implementation process of the present invention in detail below by way of specific embodiment and producing, it is intended to which help is read
Reader more fully understand the present invention essence and feature, not as to this case can practical range restriction.
The youthwort extract of embodiment 1, logwood extract, willowherb extract, the preparation of iris root extract
The youthwort extract is extracted in accordance with the following methods to be obtained：The youthwort extract be according to
Lower method extracts what is obtained：Youthwort herb is taken, drying and crushing crosses 60 mesh sieves, takes 100g to be added to CO every time2It is overcritical
In extractor, from ethanol as entrainer, entrainer accounts for the percent by volume of total extractant for 2%, extracting pressure 30Mpa,
40 DEG C of temperature, extraction time 2h extracts agent flux 30L/h, by obtained extract distilled water（Appropriate propane diols can be added to help
It is molten）1000mL is settled to, then with 0.45 μm of membrane filtration, the youthwort extract that concentration is 0.1g/mL is obtained.
The logwood extract extracts obtain in accordance with the following methods：The logwood extract is to carry in accordance with the following methods
Obtain：Bush drying and crushing is crossed after 100 mesh sieves, 100g Sappan woods are taken, according to every gram of bush 13mL Extraction solvent
Ratio is mixed with the ethanol of 50% concentration, and heating water bath is incubated 1.5h to 70 DEG C, collects supernatant, is repeated operation 2 times above, is closed
And supernatant and centrifuge, obtained supernatant will be centrifuged and be concentrated under reduced pressure into no alcohol taste, then concentrate is centrifuged, ultrafiltration, receipts
Collect filtered fluid, the albumin for adding filtrate quality 0.3% reacts 20min at 50 DEG C, centrifuge, the supernatant distillation being collected into
Water dilutes（Appropriate propane diols hydrotropy can be added）1000mL is settled to, then with 0.45 μm of membrane filtration, concentration is obtained for 0.1g/
ML logwood extract.
The willowherb extract is extracted obtain in accordance with the following methods：By willow herb herb, drying and crushing is crossed after 80 mesh sieves,
50g willow herb herb powder is taken, according to the ratio of every gram of willow herb 10mL Extraction solvent, the ethanol solution of 70% concentration, 75 DEG C of guarantors is added
Warm refluxing extraction three times, each 1h merges three filtrates, and concentration removes ethanol, uses distilled water diluting（Appropriate propane diols can be added
Hydrotropy）500mL is settled to, then with 0.45 μm of membrane filtration, the willowherb extract that concentration is 0.1g/mL is obtained.
The iris root extract is extracted in accordance with the following methods to be obtained：The iris root extract is according to lower section
Method extracts what is obtained：Using orrisroot as raw material, drying and crushing is crossed after 100 mesh sieves, takes 50g samples, is carried according to every gram of orrisroot 8mL
The ratio of solvent is taken, is well mixed with the ethanol of 85% concentration, ultrasonic wave added extracts 45min at 60 DEG C, and supernatant is collected by centrifugation
Liquid, repeats operation 2 times above, and the supernatant after merging is concentrated under reduced pressure into the 1/4 of original volume, then pure through macroreticular resin separation
Change, ethanol water gradient elution, the eluent being collected into, be concentrated under reduced pressure recovery ethanol, uses distilled water diluting（Appropriate the third two can be added
Alcohol hydrotropy）500mL is settled to, then with 0.45 μm of membrane filtration, the iris root extract that concentration is 0.1g/mL is obtained.
Embodiment 2 suppresses 5 а-reductase experiment
1st, experimental principle
A kind of suitable multifactor caused disease of acne, local androgen metabolic disorder is one of its topmost cause of disease, and hero swashs
Element can excessively cause the increase of sebaceous glands volume and sebum secretion to increase, pilosebaceous duct dyskeratosis, cause sebum row
Let out not smooth, form fat bolt, trigger acne.In sebocyte cell, androgen can be converted into work in the presence of 5 а-reductase
The stronger dihydrotestosterone of property（DHT）, sebum secretion is further stimulated, so as to enhance the ability for inducing acne.Therefore, 5 are suppressed
а-reductase can reduce the secretion of sebum, reach the effect for suppressing acne.
Testosterone catalyzed transitions are protona in the presence of reduced Coenzyme II by 5 а-reductase, if in the presence of 5 а-reduction
Enzyme inhibitor, can just suppress this course of reaction to a certain extent.Because reduced Coenzyme II has feature suction at 340nm wavelength
Receive, participate in the oxidized coenzyme Ⅱ characteristic absorption disappearance at 340nm wavelength generated after reaction.Carried out with ultraviolet specrophotometer
Determine, certain material can be reflected to whether inhibited and inhibitory action the size of 5 а-reductase.
2nd, the preparation of the composition with acne-removing
The concentration of each extract combination is determined using positive quadraturing design test.Four kinds of extract solutions prepared by embodiment 1 are according to table 1
Scheme is prepared respectively, standby.
The complex composition of table 1 suppresses the investigation factor and level of 5 а-reductase activity
In table 1 " concentration g/mL " is that extract solution is converted into raw material meter, i.e. be by every 10g dry feedstocks be made 100mL extract
The stoste of liquid is designated as 0.1g/mL；0.2 g/mL is that every 10g dry feedstocks are made into 100mL extract solutions are concentrated into original volume 1/2
（Or, it is that extract solution is settled to 50mL in terms of every 10g dry feedstocks）；0.3g/mL is that every 10g dry feedstocks are made into 100mL
Extract solution is concentrated into the 1/3 of original volume；……；By that analogy.
3rd, 5 а-reductase experiment is suppressed
3.1 test method
Through repetition test, 5 а-reductase catalystic converter system that cumulative volume is 100 μ L is established.Each composition reaction volume is shown in Table
2。
Each reagent dosage of the reaction system of table 2（μL）
| Testosterone T | 5 а-reductase | Phosphate buffer | Reduced Coenzyme II | Finasteride | Laboratory sample | |
| Blank control | 4 | 6 | 60 | 30 | ||
| Finasteride | 4 | 6 | 55 | 30 | 5 | |
| Experimental group | 4 | 6 | 55 | 30 | 5 |
The measure of blank control：Testosterone T, 5 а-reductase, phosphate buffer are added in reaction tube（pH=7.4）, reduced form
Determined after codehydrogenase Ⅱ, mixing and absorbance is determined after absorbance, 37 DEG C of constant-temperature incubation 60min, deducted under reduced Coenzyme II blank
Background values is dropped, blank drop-out value Δ A is measured0=0.07。
The measure of experimental group：Testosterone T, 5 а-reductase, phosphate buffer are added in reaction tube（pH=7.4）, reduction
Determined after type codehydrogenase Ⅱ, laboratory sample, mixing and absorbance is determined after absorbance, 37 DEG C of constant-temperature incubation 60min, deduct reduced form auxiliary
The blank of enzyme II declines background values, measures experimental group drop-out value Δ An.Using Finasteride as positive drug, the work of 5 а-reductase is judged
Whether property is suppressed, and primary Calculation inhibiting rate.Calculation formula is：
I（%）=（ΔA0-ΔAn）/ΔA0×100%
4th, result and analysis
The determination of 4.1 composition optium concentrations
Composition is shown in Table 3 to the histamine result of 5 а-reductase.As can be seen from Table 3, youthwort extract is to 5
The inhibition of а-reductase activity is preferably, secondly logwood extract；Composition suppresses the optimal of 5 а-reductase activity
Concentration proportioning is youthwort extract 0.6g/mL, logwood extract 0.5g/mL, willowherb extract 0.3g/mL, orrisroot
Extract 0.2g/mL.
The composition of table 3 suppresses the Orthogonal experiment results of 5 а-reductase activity
4.2 compositions suppress the comparative result of situation with single extract to 5 а-reductase activity
Table 4 have recorded composition and suppression situation of the single extract to 5 а-reductase activity.From table 4, roundleaf thatch cream
Dish, bush, willow herb, orrisroot single plant extract are respectively provided with different degrees of inhibitory action to 5 а-reductase, but below
Positive control Finasteride, the inhibiting rate of the composition of four compoundings is higher than positive control Finasteride, illustrates roundleaf thatch
Cream dish, bush, willow herb, orrisroot Four Plants extract have synergy in 5 а-reduction enzyme inhibition.
The composition of table 4 suppresses the comparison of situation with single extract to 5 а-reductase activity
| Finasteride | Youthwort extract | Logwood extract | Willowherb extract | Iris root extract | Composition | |
| ΔAn | 0.028 | 0.031 | 0.034 | 0.042 | 0.046 | 0.022 |
| Inhibiting rate/% | 60.00 | 55.71 | 51.43 | 40.00 | 34.29 | 68.57 |
Note：Youthwort extract, logwood extract, willowherb extract, iris root extract in table 4 are embodiment 1
In the youthwort extract, logwood extract, willowherb extract, the iris root extract that prepare；Composition is by preceding
State the youthwort extract for being converted to material concentration meter 0.6g/mL, 0.5g/mL logwood extract, 0.3g/mL willow herb
Extract, 0.2g/mL iris root extract are according to 1:1:1:1 volume ratio is formed by directly mixing.
Embodiment 3 has the preparation of the composition of acne-removing
Youthwort extract 60g, logwood extract 40g, willow herb that the method according to embodiment 1 prepares is taken to carry
Take thing 40g, iris root extract 10g to be well mixed, obtain the composition with acne-removing of the present embodiment 3.
Embodiment 4 has the preparation of the composition of acne-removing
Youthwort extract 60g, logwood extract 50g, willow herb that the method according to embodiment 1 prepares is taken to carry
Take thing 30g, iris root extract 20g to be well mixed, obtain the composition with acne-removing of the present embodiment 4.
Embodiment 5 has the preparation of the composition of acne-removing
Youthwort extract 60g, logwood extract 60g, willow herb that the method according to embodiment 1 prepares is taken to carry
Take thing 20g, iris root extract 30g to be well mixed, obtain the composition with acne-removing of the present embodiment 5.
The facial treatment essence of composition with acne-removing of the embodiment 6 containing the present invention
There is the facial treatment essence formula of acne-removing to be for this：Dipropylene glycol 2g, propane diols 3g, allantoin 0.1g, glycine betaine 3g, card
Ripple nurse 0.4g, arginine 0.4g, niacinamide 4g, shale oil sulphonic acid ester sodium 1.5g, Bacillus acidi lactici/fermented soybean product extract
2g, decoyl hydroximic acid 1.0g, o- cymene -5- alcohol 0.05g, essence 0.08g, the group with acne-removing prepared by embodiment 4
Compound 0.5g, deionized water to 100g.
The facial treatment essence of composition with acne-removing of the embodiment 7 containing the present invention
There is the facial treatment essence formula of acne-removing to be for this：Dipropylene glycol 4g, propane diols 2g, allantoin 0.15g, glycine betaine 2g,
Carbomer 0.55g, arginine 0.55g, niacinamide 2.5g, shale oil sulphonic acid ester sodium 2.5g, Bacillus acidi lactici/fermented soybean product are carried
Thing 1g is taken, decoyl hydroximic acid 0.6g, o- cymene -5- alcohol 0.07g, false portulaca oleracea extracts 2g, essence 0.1g, embodiment 4 is made
The standby composition 4g with acne-removing, deionized water to 100g.
The facial treatment essence of composition with acne-removing of the embodiment 8 containing the present invention
There is the facial treatment essence formula of acne-removing to be for this：Dipropylene glycol 6g, propane diols 1g, allantoin 0.2g, glycine betaine 1g, card
Ripple nurse 0.7g, arginine 0.7g, niacinamide 1g, shale oil sulphonic acid ester sodium 4g, Bacillus acidi lactici/fermented soybean product extract
It is prepared by 0.5g, decoyl hydroximic acid 0.4g, o- cymene -5- alcohol 0.1g, Cactus Pedicel extract 3g, essence 0.12g, embodiment 4
The composition 6g with acne-removing, deionized water to 100g.
When preparing embodiment 6-8 facial treatment essence, carried out according to following technique：
Deionized water is heated to 85 DEG C or so, dipropylene glycol, propane diols, allantoin, glycine betaine, carbomer is added and stirs
Afterwards, homogeneous, is cooled to 60-70 DEG C, adds arginine and stirs, be cooled to 45 DEG C or so, adds the cigarette dissolved in advance
Acid amides and other clouts stir.
The skin care creams of composition with acne-removing of the embodiment 9 containing the present invention
There is the skin care creams formula of acne-removing to be for this：PEG-20 methyl sesquistearate 1g, methyl sesquialter
Stearate 0.5g, cetostearyl alcohol 3g, isopropyl palmitate 2g, carbonic acid dioctyl ester 1g, dimethyl silicone polymer 1g, Australia are hard
Fruit seed oil 0.5g, Babassu seed oil glycerin polyether -8 esters 1g, bisabolol 0.2g, allantoin 0.1g, glycerine 4g, carbomer
0.4g, Sodium Hyaluronate 0.01g, o- cymene -5- alcohol 0.05g, phosphoglycerol inositol choline salt 0.1g, prepared by embodiment 4
Composition 0.5g with acne-removing, triethanolamine 0.4g, preservative 0.5g, essence 0.1g, deionized water to 100g.
The skin care creams of composition with acne-removing of the embodiment 10 containing the present invention
There is the skin care creams formula of acne-removing to be for this：PEG-20 methyl sesquistearate 1.5g, methyl times
Semi-solid fat acid esters 1g, cetostearyl alcohol 2g, isopropyl palmitate 3g, carbonic acid dioctyl ester 2g, dimethyl silicone polymer 2.5g, Australia
Nut seed oil 1.5g, Babassu seed oil glycerin polyether -8 esters 0.5g, bisabolol 0.1g, allantoin 0.15g, glycerine 6g, card
Ripple nurse 0.25g, Sodium Hyaluronate 0.05g, o- cymene -5- alcohol 0.08g, phosphoglycerol inositol choline salt 0.3g, embodiment 4 is made
The standby composition 3g with acne-removing, triethanolamine 0.25g, preservative 0.6g, essence 0.12g, deionized water to 100.
The skin care creams of composition with acne-removing of the embodiment 11 containing the present invention
There is the skin care creams formula of acne-removing to be for this：PEG-20 methyl sesquistearate 3g, methyl sesquialter
Stearate 1.5g, cetostearyl alcohol 1g, isopropyl palmitate 4g, carbonic acid dioctyl ester 4g, dimethyl silicone polymer 4g, Australia are hard
Fruit seed oil 3g, Babassu seed oil glycerin polyether -8 esters 0.1g, bisabolol 0.05g, allantoin 0.2g, glycerine 8g, carbomer
0.15g, Sodium Hyaluronate 0.1g, o- cymene -5- alcohol 0.1g, phosphoglycerol inositol choline salt 0.5g, tool prepared by embodiment 4
There are the composition 6g of acne-removing, triethanolamine 0.15g, preservative 0.8g, essence 0.15g, deionized water to 100g.
When preparing embodiment 9-11 skin care creams, carried out according to following technique：
Deionized water is heated to 85 DEG C or so, after addition glycerine, allantoin, Sodium Hyaluronate, carbomer stir,
Matter, obtains aqueous phase；By PEG-20 methyls sesquistearate, methyl sesquistearate, cetostearyl alcohol, palm fibre
Palmitic acid isopropyl propionate, carbonic acid dioctyl ester, dimethyl silicone polymer, Queensland nut seed oil, the oily esters of glycerin polyether -8 of Babassu seed,
Bisabolol is mixed, and heating water bath is to 80 DEG C or so, and stirring and dissolving obtains oil phase；Oil phase is slowly added in aqueous phase, and homogeneous,
Oil-water emulsion is obtained, triethanolamine is added and is neutralized, stirring is cooled to 45 DEG C, remaining raw material is added and stirs i.e.
.
The face cleaning gel of composition with acne-removing of the embodiment 12 containing the present invention
There is the face cleaning gel formula of acne-removing to be for this：EDETATE SODIUM 0.05g, glycerine 8g, the 1g of polyethylene glycol -32, laruyl alcohol
Polyethers sodium sulfovinate 14g, allantoin 0.1g, coconut oleoyl amine 1g, lauryl glucoside/Plantacare 818 8g, laureth phosphorus
Sour potassium 3g, lauroylamidopropyl betaine 10g, sodium lauroyl sarcosine 3g, hydroxyacetic acid 0.1g, 10- hydroxydecanoic acid 0.1g, tea
Leaf oil 0.5g, citric acid 0.18g, DMDM hydantoins 0.3g, essence 0.08g, prepared by embodiment 4 has acne-removing
Composition 1g, deionized water to 100g.
The face cleaning gel of composition with acne-removing of the embodiment 13 containing the present invention
There is the face cleaning gel formula of acne-removing to be for this：EDETATE SODIUM 0.1g, glycerine 6g, the 1.5g of polyethylene glycol -32, bay
Alcohol polyethers sodium sulfovinate 11g, allantoin 0.2g, coconut oleoyl amine 2g, lauryl glucoside/Plantacare 818 7g, laureth
Potassium phosphate 4.5g, lauroylamidopropyl betaine 8g, sodium lauroyl sarcosine 5g, hydroxyacetic acid 0.08g, 10- hydroxydecanoic acid
0.3g, tea leaf oil 0.3g, citric acid 0.26g, DMDM hydantoins 0.3g, essence 0.12g, prepared by embodiment 4 has anti-acne
The composition 4g of effect, deionized water to 100g.
The face cleaning gel of composition with acne-removing of the embodiment 14 containing the present invention
There is the face cleaning gel formula of acne-removing to be for this：EDETATE SODIUM 0.15g, glycerine 4g, the 2g of polyethylene glycol -32, laruyl alcohol
Polyethers sodium sulfovinate 9g, allantoin 0.3g, coconut oleoyl amine 4g, lauryl glucoside/Plantacare 818 5g, laureth phosphoric acid
Potassium 6g, lauroylamidopropyl betaine 6g, sodium lauroyl sarcosine 7g, hydroxyacetic acid 0.05g, 10- hydroxydecanoic acid 0.5g, tealeaves
Oily 0.1g, citric acid 0.26g, DMDM hydantoins 0.3g, essence 0.15g, the group with acne-removing prepared by embodiment 4
Compound 6g, deionized water to 100g.
When preparing embodiment 12-14 face cleaning gel, carried out according to following technique：
First laureth sodium sulfovinate is stirred in deionized water and is completely dissolved, EDETATE SODIUM, glycerine, poly- second two is added
Alcohol -32, allantoin, coconut oleoyl amine, lauryl glucoside/Plantacare 818 and laureth potassium phosphate, under the conditions of 80-90 DEG C
Water-bath insulated and stirred is cooled to 50 DEG C or so rear addition lauroylamidopropyl betaines and sodium lauroyl sarcosine to being completely dissolved
Stirring is cooled to after 40 DEG C or so to being completely dissolved, and is added citric acid regulation system pH, is added surplus stock and stir i.e.
Can.
The acne-removing of embodiment 15 is tested
1st, bacteriostatic experiment
1.1 laboratory sample:
Facial treatment essence prepared by embodiment 6, skin care creams prepared by embodiment 9, face cleaning gel prepared by embodiment 12；
Comparative example 1：Embodiment in the youthwort extract prepared with embodiment 1, the facial treatment essence of equivalent alternative embodiment 6
4 compositions with acne-removing prepared, other raw materials are identical；
Comparative example 2：The composition that logwood extract 50g, willowherb extract 30g prepared by Example 1 is mixed to get, equivalent is replaced
Composition with acne-removing prepared by the embodiment 4 changed in the skin care creams of embodiment 9, other raw materials are identical；
Comparative example 3：Youthwort extract 60g, willowherb extract 30g, the iris root extract 20g of the preparation of Example 1
Combination with acne-removing prepared by the embodiment 4 in the composition being mixed to get, the face cleaning gel of equivalent alternative embodiment 12
Thing, other raw materials are identical.
1.2 experimental method
According to《The research of protection evaluation of anti-acne cosmetics》（Household chemicals science, December the 27th in 2004
Rolled up for the 12nd phase）In described " stripping property resists（Suppression）Bacterium product bacteriostasis property test method " is determined.
1.3 experimental result
Bacteriostasis rate/% of the table 5 to different strain
| Strain | Embodiment 6 | Embodiment 9 | Embodiment 12 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Pseudomonas aeruginosa | 98 | 96 | 100 | 88 | 90 | 91 |
| Escherichia coli | 97 | 99 | 100 | 87 | 90 | 94 |
| Candida albicans | 98 | 96 | 99 | 86 | 88 | 92 |
| Staphylococcus aureus | 99 | 98 | 95 | 40 | 68 | 80 |
| Microsporon furfur | 90 | 90 | 93 | 32 | 47 | 78 |
| Propionibacterium acnes | 92 | 93 | 95 | 41 | 60 | 84 |
| Acne-removing is evaluated | It is effective | It is effective | It is effective | It is invalid | It is invalid | Effectively |
As can be seen from Table 5, the skin care item of embodiment 6,9,12 are above 90% to the inhibiting rate of six kinds of strains, say
The skin care item that bright composition of the addition present invention with acne-removing is prepared significantly effectively can prevent and suppress acne
The generation of acne；The skin care item of comparative example 1 and 2, the suppression to staphylococcus aureus, microsporon furfur and propionibacterium acnes
Rate processed is relatively low, part below 50%, illustrates that only addition youthwort extract or addition logwood extract and willow herb are extracted
The skin care item of the composition of two kinds of compositions of thing, without obvious anti-acne effect；The skin care item of comparative example 3, to Pseudomonas aeruginosa, large intestine
The inhibiting rate of bacillus and Candida albicans is higher than 90%, to staphylococcus aureus, microsporon furfur and propionibacterium acnes
Inhibiting rate be higher than 50%, effectively can prevent and suppress the generation of small pox, but inhibiting rate is again below embodiment 6,9,12
Skin care item.Illustrate that the youthwort extract in the present composition, logwood extract, willowherb extract, orrisroot are extracted
Four kinds of extracts of thing generate synergy, can effectively suppress the harmful bacteria of small pox skin surface, reach good anti-acne effect.
2nd, normal individual trial evaluation experimental
2.1 laboratory sample
Facial treatment essence prepared by embodiment 7, skin care creams prepared by embodiment 10, face cleaning gel prepared by embodiment 13；
Comparative example 4：It is prepared by the embodiment 4 in the logwood extract prepared with embodiment 1, the facial treatment essence of equivalent alternative embodiment 7
The composition with acne-removing, other raw materials are identical；
Comparative example 5：The combination that youthwort extract 60g, iris root extract 20g prepared by Example 1 is mixed to get
Composition with acne-removing prepared by the embodiment 4 in thing, the skin care creams of equivalent alternative embodiment 10, other raw material phases
Together；
Comparative example 6：Youthwort extract 60g, logwood extract 50g, the willowherb extract 30g of the preparation of Example 1 are mixed
The composition with acne-removing prepared by the embodiment 4 in obtained composition, the face cleaning gel of equivalent alternative embodiment 13 is closed,
Other raw materials are identical.
2.2 experimental method
Choosing 180 faces has the volunteer of small pox problem, age 18-28 Sui, is divided into 6 groups, every group of 30 people, respectively using implementation
The skin-protection product of example 7,10,13 and comparative example 4-6, it is sooner or later each using once daily, it is continuous to use 2 months.
Evaluation criterion：Facial oil secretion substantially tails off, whelk substantially eliminate be judged as it is effective；Facial oil secretion becomes
Few, part whelk, which is eliminated, to be judged as effectively；Facial oil is secreted without significant change, and whelk does not reduce or reduced unobvious
It is invalid to be judged as.
2.3 result of the test
The anti-acne test evaluation table of table 6
| It is effective（People） | Effectively（People） | It is invalid（People） | |
| Embodiment 7 | 21 | 9 | 0 |
| Embodiment 10 | 23 | 7 | 0 |
| Embodiment 13 | 26 | 4 | 0 |
| Comparative example 4 | 4 | 10 | 16 |
| Comparative example 5 | 7 | 13 | 10 |
| Comparative example 6 | 16 | 12 | 2 |
As shown in Table 6, the anti-acne effect of the skin care item prepared by embodiment 7,10,13 will be substantially better than comparative example 4-6
Anti-acne effect, illustrate youthwort extract, logwood extract, willowherb extract, four kinds of extracts of iris root extract
Synergy is generated, the secretion of face skin grease can be effectively reduced, reach good anti-acne effect.
The test result of the experiment of summary two, it is known that it is of the invention by youthwort extract, logwood extract,
The composition of willowherb extract, iris root extract composition, a variety of natural plant composition synergies, can effectively suppress
The bacterium of skin surface, reduces bacterial inflammation, the secretion of face skin grease can also be effectively reduced in addition, with good
Anti-acne effect.
Require supplementation with explanation to illustrate, a kind of composition cosmetics with acne-removing that the present invention is provided, not
It is limited to facial treatment essence, skin care creams and face cleaning gel.The cosmetics can also be skin-care cosmetics, such as skin care aqua, shield
Skin gel, facial treatment mask etc.；Or cleaning class cosmetics, such as mildy wash, face cleaning cream.
In the present invention, the described composition with acne-removing can mutually be added to the cosmetic as low temperature addition
In product during concrete application, each composition in the composition of the present invention can respectively be added, can also be pre-mixed being added to after preparation
In cosmetic, add and use after the composition of the present invention preferably is pre-mixed into preparation.
According to specific embodiments of the present invention, cosmetics of the invention are except including the described group with acne-removing
Outside compound, the selections of other components can be carried out according to the routine operation of this area, for example may include some conventional emulsifying agents,
Thickener, emollient（Such as vegetable oil, mineral oil, animal oil, Synthetic Oil）, NMF（Such as glycerine, propane diols, butanediol
Deng）, pH adjusting agent, surfactant etc., or further comprise other additions commonly used in art mutually such as essence, anti-corrosions
Agent, nutritional agents etc., the application of these specific compositions and consumption can be selected according to the specific species of the cosmetics, or
It is added according to routine dose, this is easy to grasp for a person skilled in the art.
Claims (10)
1. a kind of composition with acne-removing, it is characterised in that said composition includes youthwort extract, bush and carried
Take thing, willowherb extract, iris root extract.
2. the composition according to claim 1 with acne-removing, it is characterised in that described youthwort is extracted
Thing, logwood extract, willowherb extract, the mass ratio of iris root extract are 6 ︰ 4-6 ︰ 2-4 ︰ 1-3.
3. the composition according to claim 1 or 2 with acne-removing, it is characterised in that described youthwort
Extract, logwood extract, willowherb extract, the mass ratio of iris root extract are the ︰ 2 of 6 ︰, 5 ︰ 3.
4. a kind of cosmetics, it is characterised in that contain the composition with acne-removing described in claim any one of 1-3.
5. cosmetics according to claim 4, it is characterised in that the composition with acne-removing is in cosmetics
Addition be cosmetics gross weight 0.5-6%.
6. cosmetics according to claim 5, it is characterised in that the composition with acne-removing is in cosmetics
Addition be cosmetics gross weight for 1-4%.
7. cosmetics according to claim 4, it is characterised in that the cosmetics include facial treatment essence, skin care creams and
Face cleaning gel.
8. cosmetics according to claim 7, it is characterised in that described facial treatment essence includes following percentage by weight
Each component：Dipropylene glycol 2-6%, propane diols 1-3%, allantoin 0.1-0.2%, glycine betaine 1-3%, carbomer 0.4-0.7%, smart ammonia
Sour 0.4-0.7%, niacinamide 1-4%, shale oil sulphonic acid ester sodium 1.5-4%, Bacillus acidi lactici/fermented soybean product extract/butanediol
0.5-2%, decoyl hydroximic acid 0.4-1.0%, o- cymene -5- alcohol 0.05-0.1%, have acne-removing described in claim 3
Composition 0.5-6%, deionized water to 100%.
9. cosmetics according to claim 7, it is characterised in that described skin care creams include following percentage by weight
Each component：PEG-20 methyl sesquistearate 1-3%, methyl sesquistearate 0.5-1.5%, cetearyl alcohol
Alcohol 1-3%, isopropyl palmitate 2-4%, carbonic acid dioctyl ester 1-4%, dimethyl silicone polymer 1-4%, Queensland nut seed oil 0.5-3%,
Babassu seed oil glycerin polyether -8 esters 0.1-1%, bisabolol 0.05-0.2%, allantoin 0.1-0.2%, glycerine 4-8%, card
Ripple nurse 0.15-0.4%, Sodium Hyaluronate 0.01-0.1%, o- cymene -5- alcohol 0.05-0.1%, phosphoglycerol inositol choline salt
0.1-0.5%, the composition 0.5-6% with acne-removing described in claim 3, deionized water to 100%.
10. cosmetics according to claim 7, it is characterised in that described face cleaning gel includes following percentage by weight
Each component：EDETATE SODIUM 0.05-0.15%, glycerine 4-8%, the 1-2% of polyethylene glycol -32, laureth sodium sulfovinate 9-
14%, allantoin 0.1-0.3%, coconut oleoyl amine 1-4%, lauryl glucoside/Plantacare 818 5-8%, laureth potassium phosphate
3-6%, lauroylamidopropyl betaine 6-10%, sodium lauroyl sarcosine 3-7%, hydroxyacetic acid 0.05-0.1%, 10- hydroxydecanoic acid
0.1-0.5%, tea leaf oil 0.1-0.5%, the composition 0.5-6% with acne-removing described in claim 3, deionized water is extremely
100%。
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