CN110101740B - Composition for repairing skin and preparation thereof - Google Patents
Composition for repairing skin and preparation thereof Download PDFInfo
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- CN110101740B CN110101740B CN201910545517.1A CN201910545517A CN110101740B CN 110101740 B CN110101740 B CN 110101740B CN 201910545517 A CN201910545517 A CN 201910545517A CN 110101740 B CN110101740 B CN 110101740B
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- 239000000203 mixture Substances 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 241000168517 Haematococcus lacustris Species 0.000 claims abstract description 29
- 150000004676 glycans Chemical class 0.000 claims abstract description 27
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 27
- 239000005017 polysaccharide Substances 0.000 claims abstract description 27
- 241000192705 Aphanothece Species 0.000 claims abstract description 23
- 244000068988 Glycine max Species 0.000 claims abstract description 23
- 235000010469 Glycine max Nutrition 0.000 claims abstract description 23
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 238000003756 stirring Methods 0.000 claims description 21
- 230000008439 repair process Effects 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000720991 Illicium Species 0.000 claims description 8
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- 239000007788 liquid Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
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- 238000000034 method Methods 0.000 claims 1
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- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
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- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- OAVCWZUKQIEFGG-UHFFFAOYSA-O 2-(5-methyl-2H-tetrazol-1-ium-1-yl)-1,3-thiazole Chemical compound CC1=NN=N[NH+]1C1=NC=CS1 OAVCWZUKQIEFGG-UHFFFAOYSA-O 0.000 description 1
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- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 241001083841 Aquatica Species 0.000 description 1
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- KIUVQMGRTDPAFR-UHFFFAOYSA-N benzoic acid 2-hydroxy-2-phenylpropanamide Chemical compound C(C1=CC=CC=C1)(=O)O.OC(C(=O)N)(C)C1=CC=CC=C1 KIUVQMGRTDPAFR-UHFFFAOYSA-N 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000006315 carbonylation Effects 0.000 description 1
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- 230000030833 cell death Effects 0.000 description 1
- 229940081733 cetearyl alcohol Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
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- 238000012258 culturing Methods 0.000 description 1
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- 238000001514 detection method Methods 0.000 description 1
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 1
- 229940093541 dicetylphosphate Drugs 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
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- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/05—Chlorophycota or chlorophyta (green algae), e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the technical field of biological medicines, and discloses a composition for repairing and caring skin and a preparation thereof; the composition comprises the following raw materials: polysaccharide of Aphanothece crispus, Chlorella extract, Haematococcus pluvialis extract, Illicium verum leaf extract, and Glycine max seed extract; the composition has good effect in protecting epidermal cells, and can significantly improve skin moisture content, skin elasticity and skin glossiness of puerperal mother.
Description
Technical Field
The invention belongs to the technical field of biological medicines, and particularly relates to a skin repairing composition and a preparation thereof, which can be used for repairing skin of postpartum mothers.
Background
With the release of the two-birth policy, postpartum mothers are gradually increased, and the market of postpartum care products is correspondingly increased. Many pregnant women have much smoother skin than before due to hormonal changes. However, after delivery, the hormone is recovered to be normal, and the baby is in lack of sleep, so that the skin of many mothers is dry and easy to be allergic, the skin elasticity is easy to be reduced, wrinkles are generated, the skin is dull and has no luster, and the like.
Disclosure of Invention
For the above reasons, the applicant has developed a skin-repairing composition through many years of research, wherein the composition comprises the following raw materials: polysaccharide of Aphanothece crispus (Aphanothece SACRUM), extract of Chlorella VULGARIS (Chlorella VULGARIS), extract of Haematococcus PLUVIALIS (Haematococcus PLUVIALIS), extract of leaves of Illicium simonsii (TASMANNIA LANCEOLATA), and extract of seeds of Glycine max (Glycine SOJA). The composition has good effect in protecting epidermal cells, and can significantly improve skin moisture content, skin elasticity and skin glossiness of puerperal mother.
The invention is realized by the following technical scheme.
A composition for skin rejuvenation, the composition starting from: polysaccharide of Aphanothece crispus, Chlorella extract, Haematococcus pluvialis extract, Illicium verum leaf extract, and Glycine max seed extract.
The composition for repairing and caring skin is prepared from the following raw materials: 0.1-6.0 parts of polysaccharide of Aphanothece ripilus, 0.1-3.0 parts of chlorella extract, 0.1-3.0 parts of haematococcus pluvialis extract, 0.1-6.0 parts of illicium simum leaf extract and 0.1-6.0 parts of wild soybean seed extract.
The composition for repairing and caring skin is prepared from the following raw materials: 1.0-6.0 parts of polysaccharide of Aphanothece ripilus, 1.0-3.0 parts of chlorella extract, 1.0-3.0 parts of haematococcus pluvialis extract, 1.0-6.0 parts of Illicium simonsii leaf extract and 1.0-6.0 parts of wild soybean seed extract.
The use of the composition for the preparation of a product for skin rejuvenation. Especially for the repair of the postpartum mother.
Wherein the composition is prepared as a liquid formulation.
The preparation method of the material body preparation comprises the following steps:
(1) adding polysaccharide of Aphanothece purpurea, Chlorella extract, Haematococcus pluvialis extract, and Illicium pseudo-star leaf extract into deionized water, stirring, and mixing to obtain solution;
(2) adding semen glycines extract into the above solution of (1), heating to 40-45 deg.C, stirring for 10.5-3 min, and homogenizing for 10.5-3 min; then, the mixture is stirred and cooled to room temperature to obtain a liquid preparation.
Wherein:
(1) polysaccharide of Aphanothece SACRUM (Aphanothece Sacrum) can form a protective film on skin surface for keeping moisture and preventing and killing harmful substances. Polysaccharide of Aphanothece SACRUM (Aphanothece Sacrum) is one of the largest known natural molecules at present, and the molecular weight is 2900 ten thousand daltons, so the polysaccharide has good film forming effect; the raw material has a plurality of hydroxyl groups in the molecular structure, so that the raw material has good hygroscopicity and brings a good water retention effect to skin. Researches show that polysaccharide of Aphanothece moschata (Aphanothece Sacrum) can effectively reduce protein carbonylation caused by PM2.5, thereby reducing the damage of PM2.5 to skin.
(2) Chlorella (Chlorella VULGARIS) extract, and Haematococcus PLUVIALIS (Haematococcus PLUVIALIS) extract. The synergistic effect of these two materials can enhance the DNA repair of the skin and increase the antioxidant system of the skin, providing deep nighttime repair. The raw material composition can promote the activities of night repair enzymes UVDE (UV damage endonuclease), OGG1 (guanine glycosylase) and TRX (thioredoxin) to generate repair action.
(3) The pseudostellera lanceolata (TASMANNIA LANCEOLATA) leaf extract has quick anti-allergy and soothing effects. Postpartum mother promotes the generation of inflammation medium P substance due to mental stress, hormone secretion and the like, the P substance generates inflammation factors IL-1 alpha, and the IL-1 alpha acts on fibroblast to generate inflammation factors such as IL-8 and the like. The extract of leaves of pseudostellera lanceolata (TASMANNIA LANCEOLATA) can inhibit IL-8 production, thereby suppressing inflammatory reaction and achieving optimal sedative effect.
(4) Semen GLYCINEs (Glycine SOJA) extract is prepared by coating the above effective components into liposome with soybean enzymolysis phospholipid to promote penetration of the effective components and improve bioavailability of the effective components. The double-layer structure of the liposome shell is similar to the structure of the skin horn intercellular substance, so that the liposome shell can easily enter the intercellular substance, after the shell is dissolved, on one hand, the effective components are released, and on the other hand, the dissolved shell can enhance the skin barrier and play a good role in water retention.
The polysaccharide of the Temple Porphyra aquatica (Aphanthece Sacrum) of the present invention is purchased from Dadongheng chemical company, Japan, and has a batch number of 20190202.
The CHLORELLA (Chlorella VULGARIS) extract and Haematococcus PLUVIALIS (Haematococcus PLUVIALIS) extract of the present invention were obtained from Greenaltec, Spain under a lot number of 20190106.
The pseudoanise (TASMANNIA LANCEOLATA) leaf extract of the present invention was purchased from southern cross, Australia under lot number 20190118.
The extract of the seeds of the wild soybean (Glycine SOJA) is purchased from Luca Meyer of France, and the batch number is 20190117.
Detailed Description
The technical solutions of the present invention are described below with specific examples, but the scope of the present invention is not limited thereto.
The embodiments described in this specification are merely illustrative of implementations of the inventive concept and the scope of the present invention should not be considered limited to the specific forms set forth in the embodiments but rather by the equivalents thereof as may occur to those skilled in the art upon consideration of the present inventive concept. While the following embodiments of the invention have been described, the invention is not limited to the specific embodiments and applications described above, which are intended to be illustrative, instructive, and not limiting. Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto without departing from the scope of the invention as defined by the appended claims.
The following tests are conclusion tests of research personnel based on multiple creative tests and on the technical scheme to be protected by the invention.
Test 1 epidermal cell protection test
Test 1 group: 1.0g of Aphanothece purpurea polysaccharide, 1.5g of chlorella vulgaris extract, 1.5g of haematococcus pluvialis extract, 1.0g of illicium simsii leaf extract and 1.0g of wild soybean seed extract.
Test 2 groups: 1.0g of polysaccharide of Aphanothece ripilus, 1.5g of haematococcus pluvialis extract, 1.0g of pseudo-aniseed leaf extract and 1.0g of wild soybean seed extract.
Run 3 groups: 1.0g of polysaccharide of Aphanothece purpurea, 1.5g of chlorella vulgaris extract, 1.0g of illicium simonsii leaf extract and 1.0g of wild soybean seed extract.
Run 4 groups: 1.0g of Aphanothece purpurea polysaccharide, 1.5g of chlorella vulgaris extract, 1.5g of haematococcus pluvialis extract and 1.0g of soyabean seed extract.
Run 5 groups: 1.0g of polysaccharide of Aphanothece ripilus, 1.5g of chlorella extract, 1.5g of haematococcus pluvialis extract and 1.0g of illicium simonsii leaf extract.
Test 6 groups: 1.5g of chlorella extract, 1.5g of haematococcus pluvialis extract, 1.0g of illicium simonsii leaf extract and 1.0g of wild soybean seed extract.
The test method comprises the following steps: taking epidermal cells, adding MEM (minimum essential medium) without calf serum into the epidermal cells when the epidermal cells grow until the fusion rate reaches more than 80%, performing synchronization treatment for 12h, performing trypsinization collection, counting, adjusting the cell concentration, and inoculating the cells to a 24-well culture plate. After the cells adhere to the wall, 200 mug/ml of test group cosmetics prepared by dilution with a culture medium in advance are added for incubation, and the positive control is sodium hyaluronate (200 mug/ml). And after 24h, drying the mixture in a superclean bench at a certain wind speed, adding a fresh culture medium, continuously culturing for 24h, and performing MTT (methyl thiazolyl tetrazolium) determination. The group without any treatment was used as a blank control in the test. The dry cell death rate (%) and the protection rate (%) were calculated by the following formulas.
Cell dry mortality (%) - (1-OD value in detection group/OD value in normal group). times.100%
Percent protection (%) (blank cell Dry mortality-test group cell Dry mortality)/blank cell Dry mortality × 100%
And (3) test results: see table 1.
TABLE 1 comparison of epidermal cell mortality and protection rates for the various test groups
Note: p <0.01, P <0.05 compared to control.
And (4) test conclusion: (1) the above tests show that 5 components in the composition of the present invention have synergistic effect, and the cell protection effect is reduced by removing any one component; (2) under the premise of the same dosage, the 5 components of the composition can improve the protection rate of cells and reduce the death rate of the cells through synergistic action, thereby ensuring that epidermal cells have better activity, and solving the problems of water shortage, dryness, reduced elasticity and the like of the epidermis.
Preparation examples
Example 1
The composition comprises the following raw materials: 1.0g polysaccharide of Aphanothece crispus (Aphanothece SACRUM), 1.5g extract of Chlorella VULGARIS (Chlorella VULGARIS), 1.5g extract of Haematococcus PLUVIALIS (Haematococcus PLUVIALIS), 1.0g extract of leaves of Illicium pseudo-simum (TASMANNIA LANCEOLATA), and 1.0g extract of seeds of Glycine max (Glycine SOJA).
The preparation method comprises the following steps:
(1) adding polysaccharide of Aphanothece purpurea, Chlorella extract, Haematococcus pluvialis extract, and Illicium verum leaf extract into 100ml deionized water, stirring, and mixing to obtain solution;
(2) adding semen glycines extract into the above solution, heating to 40-45 deg.C, stirring for 2 min, homogenizing for 2 min, stirring, and cooling to room temperature to obtain liquid preparation.
Example 2
The composition comprises the following raw materials: polysaccharide 3g of Aphanothece crispus (Aphanothece SACRUM), extract 2g of CHLORELLA (Chlorella VULGARIS), extract 3g of Haematococcus PLUVIALIS (Haematococcus PLUVIALIS), extract 3.5g of leaves of pseudo-anise (TASMANNIA LANCEOLATA), and extract 3g of seeds of Glycine max (Glycine SOJA).
The preparation method comprises the following steps:
(1) adding polysaccharide of Aphanothece purpurea, Chlorella extract, Haematococcus pluvialis extract, and Illicium verum leaf extract into 100ml deionized water, stirring, and mixing to obtain solution;
(2) adding semen glycines extract into the above solution, heating to 40-45 deg.C, stirring for 0.5 min, homogenizing for 3 min, stirring, and cooling to room temperature to obtain liquid preparation.
Example 3
The composition comprises the following raw materials: 6.0g of Aphanothece purpurea polysaccharide, 3g of chlorella vulgaris extract, 3g of haematococcus pluvialis extract, 5.5g of illicium pseudostellatum leaf extract and 5g of wild soybean seed extract.
The preparation method comprises the following steps:
(1) adding polysaccharide of Aphanothece purpurea, Chlorella extract, Haematococcus pluvialis extract, and Illicium verum leaf extract into 100ml deionized water, stirring, and mixing to obtain solution;
(2) adding semen glycines extract into the above solution, heating to 40-45 deg.C, stirring for 3 min, homogenizing for 1 min, stirring, and cooling to room temperature to obtain liquid preparation.
Example 4
The composition comprises the following raw materials: 4g of Aphanothece purpurea polysaccharide, 2.5g of chlorella vulgaris extract, 1.5g of haematococcus pluvialis extract, 2g of illicium simsii leaf extract and 2g of wild soybean seed extract.
The preparation method comprises the following steps:
(1) adding polysaccharide of Aphanothece purpurea, Chlorella extract, Haematococcus pluvialis extract, and Illicium verum leaf extract into 100ml deionized water, stirring, and mixing to obtain solution;
(2) adding semen glycines extract into the above solution, heating to 40-45 deg.C, stirring for 1.5 min, homogenizing for 2 min, stirring, and cooling to room temperature to obtain liquid preparation.
Example 5
Night repair cream composition: see table 2.
TABLE 2 night repair cream
The preparation method comprises the following steps:
(1) adding caprylic/capric triglyceride, cetearyl alcohol, dicetyl phosphate, and ceteth-10 phosphate into oil phase kettle, heating to 80-85 deg.C, stirring, and dissolving completely.
(2) Adding water, EDTA disodium, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer and glycerol into a water phase kettle, stirring until the materials are completely dissolved, then adding pre-dissolved butanediol, p-hydroxyacetophenone and 1, 2-hexanediol solution, heating to 80-85 ℃, and stirring until the materials are completely dissolved for later use.
(3) Add (2) above to (1) and homogenize under vacuum for 2 minutes. Then cooling to 40-45 ℃, adding sodium hydroxide and citric acid to adjust the pH, then adding the composition of the example 1, butanediol, 1, 2-pentanediol and hydroxyphenylpropionamide benzoic acid, and uniformly stirring to obtain the cream.
Test example 2
The test method comprises the following steps:
(1) the night repair cream of table 1 was used by 10 mothers who produced it, once before going to bed every night. The application is continued for 28 days.
(2) The following test data were collected on the beginning (T0), day 10 (T10), and day 28 (T28) using MPA580 skin tester manufactured by CK company, germany: skin moisture content, skin elasticity, skin gloss test results: see tables 3-5.
(1) Skin moisture content
TABLE 3 skin moisture content
Note: p <0.01, P <0.05 compared to day 0.
(2) Elasticity of skin
TABLE 4 skin elasticity
| Group of | Elasticity number at 0 day | Elasticity number of 10 days | Elasticity number of 28 days |
| Test group | 0.6468±0.0127 | 0.6763±0.0105* | 0.7152±0.0101** |
Note: p <0.01, P <0.05 compared to day 0.
(3) Skin gloss
TABLE 5 skin gloss
| Group of | Elasticity number at 0 day | Elasticity number of 10 days | Elasticity number of 28 days |
| Test ofGroup of | 5.9±0.2 | 6.4±0.2* | 6.4±0.2* |
Note: p <0.01, P <0.05 compared to day 0.
And (4) test conclusion: after the cream prepared by adopting the skin repairing composition as the raw material is used for 10 days and 28 days, the moisture content, the elasticity and the glossiness of the skin are obviously improved.
Claims (6)
1. A composition for postpartum skin rejuvenation characterized by: the composition comprises the following raw materials: 0.1-6.0 parts of polysaccharide of Aphanothece ripilus, 0.1-3.0 parts of chlorella extract, 0.1-3.0 parts of haematococcus pluvialis extract, 0.1-6.0 parts of illicium simum leaf extract and 0.1-6.0 parts of wild soybean seed extract.
2. The composition for postpartum skin repair according to claim 1, wherein the composition is prepared from the following raw materials: 1.0-6.0 parts of polysaccharide of Aphanothece ripilus, 1.0-3.0 parts of chlorella extract, 1.0-3.0 parts of haematococcus pluvialis extract, 1.0-6.0 parts of Illicium simonsii leaf extract and 1.0-6.0 parts of wild soybean seed extract.
3. Composition for postpartum skin rejuvenation according to claim 1 or 2 characterised in that it is used for the preparation of a product for postpartum skin rejuvenation.
4. A composition for postpartum skin rejuvenation according to claim 1 or 2 wherein the composition is prepared as a liquid formulation.
5. The composition for postpartum skin repair according to claim 4, characterized in that the liquid formulation is prepared by the method comprising:
(1) adding polysaccharide of Aphanothece purpurea, Chlorella extract, Haematococcus pluvialis extract, and Illicium pseudo-star leaf extract into deionized water, stirring, and mixing to obtain solution;
(2) adding semen glycines extract into the above solution, heating to 40-45 deg.C, stirring for 0.5-3 min, homogenizing for 0.5-3 min, stirring, and cooling to room temperature to obtain liquid preparation.
6. The composition for postpartum skin repair of claim 5, wherein the liquid formulation is prepared as a product as a raw material.
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| CN111265441A (en) * | 2020-03-13 | 2020-06-12 | 佛山市奥姿美生物科技有限公司 | Composition capable of enhancing skin night repair and regeneration capacity and application thereof |
| CN111991340B (en) * | 2020-10-10 | 2022-11-08 | 广州澳希亚实业有限公司 | Composition with effects of repairing, relieving and helping sleep, preparation method and application |
| CN112972273A (en) * | 2021-03-02 | 2021-06-18 | 广州德贝芙生物科技有限公司 | Liposome and preparation method thereof |
| CN113101299A (en) * | 2021-03-04 | 2021-07-13 | 圣珂兰投资有限公司 | Application of blue algae polysaccharide in temple of aquatic animals in preparation of medicines for treating scalds |
| CN115245477A (en) * | 2021-04-28 | 2022-10-28 | 广州市索柔生物科技有限公司 | After-sun repair compound, preparation method and application thereof |
| CN114010524A (en) * | 2021-12-01 | 2022-02-08 | 浙江宜格企业管理集团有限公司 | Moisturizing composition for cosmetics |
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