CN110522698A - A kind of scalp injury repairs Essence and preparation method thereof - Google Patents

Abstract

A kind of scalp injury repairs Essence and preparation method thereof, be related to Scalp reconstruction field, which includes the component of following weight percent: glycerol 5-10%, 1.3- butanediol 5-10%, glycyrrhizin 0.1-1%, zinc gluconate 0.1-0.5%, glycogen 1-5%, activity extract 15-25%, beta glucan 0.5-3%, Sodium Hyaluronate 0.05-1%, hydrolytic collagen 0.1-1%, compound amino acid 0.5-5%, biotin 0.05-1%, copper peptide 0.01-0.1%, surplus are water.The present invention can be directed to using the reparation of scalp injury made of above-mentioned raw materials component Essence and be damaged scalp, repairing damage scalp, it can reduce hyperemia, accelerate micro- white Guan Zhangli around skin, mitigate oedema, local anti-inflammatory, accelerating wound healing supplements scalp nutrition, promote skin regeneration, is conducive to hair restoration and other effects.

Description

A kind of scalp injury repairs Essence and preparation method thereof

Technical field:

The present invention relates to Scalp reconstruction fields, and in particular to a kind of scalp injury repairs Essence and preparation method thereof.

Background technique:

The scalp part one of most thin as human skin is easy to be damaged, and environmental stimuli object, bacterium and hair rinse are residual Chemical substance stayed etc. is easy to induce the inflammation of damaged scalp, a series of problems, such as influencing scalp care, lead to alopecia.Now Lack the Essence specifically for scalp injury nursing in the market.

Summary of the invention:

In place of overcoming above-mentioned the shortcomings of the prior art, and a kind of scalp injury is provided and is repaired Multiple Essence, the Essence can repair damaged scalp and hair follicle, cure the inflammation on scalp, and can mitigate congested, acceleration Micro- white Guan Zhangli around skin mitigates oedema, local anti-inflammatory, accelerating wound healing, supplement hair nutrition and other effects, furthermore this hair Another bright purpose is to provide a kind of preparation method of reparation Essence, and the preparation method is simple to operation, can be large quantities of Amount industrialized production simultaneously improves production efficiency.

The technical solution adopted by the present invention are as follows: a kind of scalp injury reparation Essence, which includes following weight hundred The component of score: glycerol 5-10%, 1.3- butanediol 5-10%, glycyrrhizin 0.1-1%, zinc gluconate 0.1-0.5%, sugar Former 1-5%, activity extract 15-25%, beta glucan 0.5-3%, Sodium Hyaluronate 0.05-1%, hydrolytic collagen 0.1-1%, Compound amino acid 0.5-5%, biotin 0.05-1%, copper peptide 0.01-0.1%, surplus are water.

Preferably, the Essence includes the component of following weight percent: glycerol 7-8%, 1.3- butanediol 6-7%, Glycyrrhizin 0.4-0.8%, zinc gluconate 0.2-0.3%, glycogen 2-4%, activity extract 18-22%, beta glucan 1.5-2.3%, Sodium Hyaluronate 0.07-0.09%, hydrolytic collagen 0.3-0.7%, compound amino acid 2-2.7%, biotin 0.1-0.4%, copper peptide 0.04-0.08%, surplus are water.

Preferably, the weight percent of the component of the activity extract and each component are as follows: shaddock fruit extracting solution 3-5%, ferment Female extracting solution 3-5%, loquat leaf extract 3-5%, horse chestnut extracting solution 3-5%, centella asiatica extract 3-5%.

Preferably, the weight percent of the component of the activity extract and each component are as follows: shaddock fruit extracting solution 4%, yeast Extracting solution 4%, loquat leaf extract 5%, horse chestnut extracting solution 5%, centella asiatica extract 3%.

Another technical solution provided by the invention are as follows: a kind of scalp injury repairs the preparation method of Essence, the preparation Method the following steps are included:

Step 1: being added the water of formula ratio, glycerol, 1.3- butanediol, Sodium Hyaluronate in agitated kettle and be mixed, then Glycyrrhizin, zinc gluconate and the glycogen of formula ratio are added into agitated kettle and is stirred, is warming up to 70 DEG C -75 DEG C, makes Dissolution of raw material is complete in agitated kettle, keep the temperature 10-15min after be cooled to 40 DEG C -45 DEG C it is spare；

Step 2: by the activity extract of formula ratio, beta glucan, hydrolytic collagen, compound amino acid, biotin, copper peptide It sequentially adds in agitated kettle, stirs and evenly mixs；

Step 3: discharging, filling, packaging are got product after the assay was approved.

Glycerol is a kind of viscous liquid of colorless and odorless, has effects that moisturizing water lock.It can be in skin after glycerol use Surface forms layer protecting film, protects infringement of the skin not by the dust and impurities in air, improves skin immunity, makes skin Long-acting holding water profit.

Butanediol is very common in cosmetics, and the English name often occurred is: Butylene Glycol, alias are called: 1, 3- dihydroxy butane, is one kind of polyalcohol, and moisturizer is often done in cosmetics and solvent uses, in terms of moisturizing, due to fourth Glycol is small molecule moisturizing composition, so grabbing water ratio very little, while also having certain bacteriostasis.

Glycyrrhizin (also known as glycyrrhizic acid, due to pleasantly sweet also known as be glycyrrhizin), it is multiple that glycyrrhizic acid is able to suppress virus System, the ability of absorption and penetrating cell, have antiviral activity, are able to suppress certain incoherent DNA, RNA virus growth, but The proliferation activity of normal cell is not influenced.Glycyrrhizic acid has anti-inflammatory effect, may be by inhibiting needed for amino acid (AA) hydrolysis Phospholipase A2 inhibits the release and synthesis of prostaglandin (PGS), because glycyrrhizic acid inhibits the work of media such as prostaglandin (PGS) With closely related with its anti-inflammatory mechanisms.

Zinc gluconate is common zinc tonic, is mainly used for baby, old age, gravid woman because growing hair caused by zinc-deficiency It is slow to educate, malnutritive, apositia, recurrent oral ulceration, the diseases such as skin acne.

Glycogen is stored in liver cell and myocyte's slurry, and shape is the particle to differ in size, meets iodine then browning color, readily soluble Yu Shui.Glycogen is not equal to carbohydrate, only one kind of carbohydrate.Carbohydrate is classified and biochemical point from the angle of tissue chemical technology Class is simultaneously non-uniform.From histochemical angle, carbohydrate can slightly be divided into polysaccharide, neutral liquid glucose substance and acidic mucosubstance and viscous egg White and mucolipid.The main finger glycogen of polysaccharide, the condensate being made of many glucose molecules with glycosidic bond.

Contain aurantiin in shaddock fruit extracting solution, aurantiin has anti-inflammatory and antalgic, antiviral, antibacterial and eye aldose reduction always The effect of enzyme.

Yeast extract has delay skin aging, accelerates epidermal cell repairing, is anti-oxidant, remove free radical, provide skin Skin nutrition promotes collagen synthesis, smoothes away wrinkles, refines pore, soft and full skin and other effects.

Loquat-leaf extract is that the leaf of Oleaceae plants glossy privet (Ligustrum lucidum Ait.) or rosaceae are planted The leaf of object loquat Eriobotrya japonica (Thunb.) Lindl., main component is ursolic acid.Ursolic acid very likely at For the efficient new anticancer drug of low toxicity.Reducing blood lipid, blood pressure lowering, antiatherosclerosis；It can increase coronary vasodilator blood flow, energy Improve coronary disease circulation, and keep coronary artery sexual exhaustion compensatory, reaches cardiac effect, and improve cardiac muscle to the embedding effect of heart tonifying Sensibility increases heart discharge, weakens myocardium irritability and conductibility, has anti-ventricular fibrillation, auricular fibrillation and the paroxysmal heart The effects of rate is not normal, and have the heartthrob effect that recovers from fatigue.

Horse chestnut extracting solution can protect arteries and structural integrity, improve vein function, combine anti-inflammatory and antioxygen Change etc. plays multi-efficiency；Horse chestnut extract is able to suppress Collagenase, hyaluronidase, B- glucuronidase and bullet Property enzyme；Can be played in external prescription promote blood circulation, promote wound healing, antioedematous, it is anti-inflammatory it is impervious go out and vascular protection It acts on (go black eye, go red capillary, is crease-resistant, maintenance).Aescin is the most important ingredient for mitigating inflammation in conker, It can effectively improve the complete of blood vessel astillen by filling up veinlet and capillary microscopic nicks and subtle visible gap Property, therefore horse chestnut helps to repair capillary.

Centella asiatica extract contains asiatic acid and brahmic acid, and centella can be with compact epidermis and corium interconnecting piece Point, skin can be made to limber up, help to solve cutis laxa phenomenon, keep skin smooth flexible；Help promotes glue in skin corium Former albumen is formed, and fibrin is regenerated, and reconnect is got up, and is inherently eliminated mother's line, and skin is made to reach compact smooth Effect.Impaired organization healing and consolidation skin can also be helped.Can promote close connection between epidermis and corium and The increase for inhibiting fat cell prevents hydroderma, obesity occurs.Centella can be with compact epidermis and corium coupling part, energy Skin is set to limber up, help promotes collagen in skin corium to be formed, and has the effect for enabling skin compact.Centella asiatica extract system In there are the instability factors such as part albumen, carbohydrate, it is poor so as to cause entire centella asiatica extract system stability, for a long time Placement is easy to produce precipitation and precipitating (referring to Master's thesis: the preparation of Gotu Kola P.E and its application in cosmetics, Nie Gorgeous peak, Ji'nan University, 2017-07-03)

Beta glucan can promote macrophage breeding, and macrophage is not only the non-single-minded cell toxicant of malignant cell Element, while it can also attract immunocompetent cell and other white blood corpuscles, to promote wound healing and generate normal tissue.

Sodium Hyaluronate: skin is burnt by light caused by solar exposure or day toast, such as erythrosis, blackening, decortication Deng the mainly effect of the ultraviolet light in sunlight.Sodium Hyaluronate passes through the proliferation and differentiation for promoting epidermal cell, and removes The effect of oxygen radical can promote the regeneration of injury skin, and use also has certain prevention effect in advance.Its mechanism of action with Common ultraviolet absorbing agent is different in suncream, and therefore, HA is used in mixed way with ultraviolet absorbing agent in sunlight screening skin-protecting product, tool There is synergistic effect, skin injury caused by the transmission of ultraviolet light and a small amount of ultraviolet light to transmission can be reduced simultaneously and repaired It is multiple, play double protection.

Hydrolytic collagen is a kind of efficient moisture-retention composition, skin-active, inducing tissue regeneration, the main bonding in human connective tissue Substance, molecular weight is big, moisture-retaining capacity more preferably compared with polyalcohols, mainly to support cell, especially suitable for after skin exfoliating, Skin is in physical therapy made by the most thin stage.Collagen has good permeability and moisturizing power, is mainly used in more scar, anti- It wrinkles, the conditioner of pachylosis patient.Collagen and its hydrolysate compatibility are strong, can cooperate with many functional components to mention It is high they the effect of；Use can effective hair conditioning in shampoo.

There are many types for compound amino acid, and raw material, which mainly divides, plant type and animal-type.Plant type compound amino acid is with day Right high-protein plant is that raw material is extracted from plants using advanced Biochemical Engineering technology, separate a variety of amino acid it is exquisite and At.Animal-type compound amino acid after microbial fermentation, acid and alkali hydrolysis processing, is sprayed using various high protein animal bodies as raw material Mist drying is process.

Biotin (Biotin) is one of B family vitamin, also known as biotin, vitamin B7, biotin (Coenzyme R) Deng.Biotin is water-soluble (vitamin) B group members.Content is more in liver, kidney, yeast, cow's milk, is the fixed titanium dioxide of organism An important factor for carbon.It is easy to combine with protein a kind of in Egg-white, large amounts of food raw albumen can hinder the absorption of biotin to lead Cause egg-white injury, such as depilation, weight loss, dermatitis.Biotin is in the biochemical reactions approach such as Fatty synthesis, gluconeogenesis It plays an important role.

Copper peptide: is formed by GHK (tri-peptide molecule, sequence are glycyl-histidyl-lysine) and copper ion Compound, copper peptide are used as strong organization protection and antiphlogistic in the present invention, protect wounded tissue further from aoxidizing Damage, is also a kind of signal peptide, promotes the degradation of a large amount of collagen collection polymers outside scar, the normal collagen of skin Synthesis, elastin, the generation of proteoglycans and grape amine glycan, the speed of growth of the type of different cells, migration, anti-inflammatory And Antioxidation reaction.Macrophage is promoted to be flowed into injury, release growth Ginza albumen hair follicle stimulating grows hair.

The invention has the benefit that the present invention use scalp injury made of above-mentioned raw materials component to repair Essence can be with For scalp is damaged, repairing damage scalp can reduce hyperemia, accelerate micro- white Guan Zhangli around skin, mitigate oedema, part Anti-inflammatory, accelerating wound healing supplements scalp nutrition, promotes skin regeneration, is conducive to hair restoration and other effects.Wherein activity is extracted Object have the function of it is anti-oxidant, activate stem cell, delay cell senescence, promote cell Proliferation, enhance cell metabolism, activated cell Vigor, through the invention in various raw materials compatibility, it is unstable under the conditions ofs optical heat radiation etc. to can solve activity extract The case where.Contain copper peptide in inventive formulation, has the effects that promote natural on-off cycles of hair growth, wound healing.It can not only promote skin The regeneration of skin epithelial tissue, makes horn cell and proliferation of fibroblast, and scalp hair follicles can also be made no longer fragile sensitive, increase head Send out density and toughness.In addition, the preparation method of the Essence is easy to operate, easily implement, to relying property of device independence, production cost Low, high production efficiency.

Specific embodiment:

Invention is further explained in conjunction with specific embodiments:

Embodiment one is configured to embodiment three using the raw material of the formula ratio in following table:

Compound amino acid of the embodiment one into embodiment three is configured using formula as below:

Embodiment one is prepared to embodiment three using following preparation method, it is specific the preparation method is as follows:

A kind of scalp injury repairs the preparation method of Essence, the preparation method the following steps are included:

Step 1: being added the water of formula ratio, glycerol, 1.3- butanediol, Sodium Hyaluronate in agitated kettle and be mixed, then Glycyrrhizin, zinc gluconate and the glycogen of formula ratio are added into agitated kettle and is stirred, is warming up to 70 DEG C -75 DEG C, makes Dissolution of raw material is complete in agitated kettle, keep the temperature 10-15min after be cooled to 40 DEG C -45 DEG C it is spare；

Step 2: by the activity extract of formula ratio, beta glucan, hydrolytic collagen, compound amino acid, biotin, copper peptide It sequentially adds in agitated kettle, stirs and evenly mixs；

Step 3: discharging, filling, packaging are got product after the assay was approved.

Wherein the ingredient in activity extract is all made of commercial product and compound.

The formula of comparative example one to three is as follows:

Specific raw material	Comparative example one	Comparative example two	Comparative example three
				Glycerol	5kg	8kg	10kg
1.3- butanediol	10kg	7kg	5kg
				Glycyrrhizin	0.1kg	1kg	0kg
Zinc gluconate	0.5kg	0.2kg	0.1kg
				Glycogen	3kg	1kg	5kg
Shaddock fruit extracting solution	0kg	3kg	4kg
				Yeast extract	0kg	5kg	4kg
Loquat leaf extract	0kg	3kg	5kg
				Horse chestnut extracting solution	0kg	4kg	5kg
Centella asiatica extract	0kg	4kg	3kg
				Beta glucan	0.5kg	1kg	3kg
Sodium Hyaluronate	0.05kg	0.4kg	1kg
				Hydrolytic collagen	1kg	0.1kg	0.7kg
Compound amino acid	2.5kg	0.5kg	5kg
				Biotin	1kg	0.05kg	0.3kg
Copper peptide	0.07kg	0kg	0.01kg
				Water	56.28kg	61.65kg	48.29kg

Using effect experiment:

(1) hygienic physicochemical data test:

Examine the sanitary index of the Essence of material rate configuration of the embodiment one into embodiment three, specific inspection data It is as follows:

As can be seen from the above table, the Scalp reconstruction Essence that the present embodiment one is prepared into embodiment three meets sanitary standard Requirement, be safe and reliable.

As can be seen from the above table, the reparation Essence that embodiment one is prepared into embodiment three in the present invention has good Stability has preferable cold-resistant and heat resistance, without there is phenomena such as separation bleed in the case where low temperature and high temperature. And activity extract is not added in comparative example one, the system stability for repairing Essence is also preferable, comparative example two and comparative example three In be added with activity extract, but comparative example two is not added with copper peptide, and comparative example three is not added with glycyrrhizin, comparative example two with The system stability of Essence prepared by comparative example three is poor, and resist cold poor heat resistance, easily analyses under the conditions ofs optical heat radiation etc. Water, segregation phenomenon, the present inventor's supposition are that the active constituent in copper ion and activity extract in copper peptide generates stable cooperation Object, improves the stability of whole system, and glycyrrhizin and copper peptide are the orderly macromolecular of structure height, these macromoleculars it Between form the reticular structure of intersection, activity extract is wrapped in the gap between macromolecular repeatedly, avoids activity extract It waits movements and leads to precipitation or the generation of segregation phenomenon.In addition, the present inventor speculates that amino, hydroxyl in formula etc. can be to solution In copper ion carry out chelating, formed frame pitch reticular structure, further increase the stability of entire prescription system.

(2) using effect is tested:

Choosing scalp respectively, there is the serious volunteer 160 of itch redness hair loss to be divided into four groups for each person, and every group of 40 people have Body are as follows: one group of embodiment, two groups of embodiment, three groups of embodiment and control group, one group of essence prepared using embodiment one of embodiment Magnificent liquid, two groups of Essences prepared using embodiment two of embodiment, three groups of Essences prepared using embodiment three of embodiment are right The commercially available shampoo with Scalp reconstruction function is used according to group, and embodiment one to three groups of embodiment, control group is allowed to use phase The product answered is evaluated after 1 week, 4 weeks, 8 weeks, specific evaluation criterion are as follows: " 0 grade " to no effect, itching of the scalp, falls redness Hair；" 1 grade " has slight effect, and itching of the scalp weakens, and red and swollen area reduces, hair loss amount reduces；" 2 grades ", effectively, itching of the scalp Obvious to weaken, red and swollen area has apparent reduction, hair loss amount less；" 3 grades ", excellent effect, scalp no longer itch, redness disappear It loses, hair loss amount is less.

As can be seen from the above table, the Essence that the embodiment of the present invention one is prepared into embodiment three treatment scalp inflammation, The problems such as red and swollen, itch, aspect had the effect of protrusion, can repair scalp injury faster, was somebody's turn to do compared to having in the market The shampoo of curative effect has excellent repair function.

It is damaged in conclusion the present invention can be directed to using the reparation of scalp injury made of above-mentioned raw materials component Essence Scalp, repairing damage scalp can reduce hyperemia, accelerate micro- white Guan Zhangli around skin, mitigate oedema, local anti-inflammatory, accelerate Wound healing supplements scalp nutrition, promotes skin regeneration, is conducive to hair restoration and other effects.Wherein activity extract has anti- It aoxidizes, activate stem cell, the effect that delays cell senescence, promoting cell Proliferation, enhancing cell metabolism, activated cell vigor.This Contain copper peptide in invention formula, has the effects that promote natural on-off cycles of hair growth, wound healing.It can not only promote skin epidermis tissue Regeneration, makes horn cell and proliferation of fibroblast, and scalp hair follicles can also be made no longer fragile sensitive, increases hair density and strong Toughness.In addition, the preparation method of the Essence is easy to operate, easily implement, to relying property of device independence, production cost is low, production is imitated Rate is high.

For those skilled in the art, it is various corresponding that other can be made according to above technical scheme and design Change and deformation, and all these change and modification all should belong within the scope of protection of the claims of the present invention.

Claims (5)

1. a kind of scalp injury repairs Essence, it is characterised in that: the Essence includes the component of following weight percent: glycerol 5-10%, 1.3- butanediol 5-10%, glycyrrhizin 0.1-1%, zinc gluconate 0.1-0.5%, glycogen 1-5%, activity mention Take object 15-25%, beta glucan 0.5-3%, Sodium Hyaluronate 0.05-1%, hydrolytic collagen 0.1-1%, compound amino acid 0.5- 5%, biotin 0.05-1%, copper peptide 0.01-0.1%, surplus are water.

2. scalp injury according to claim 1 repairs Essence, it is characterised in that: the Essence includes following weight The component of percentage: glycerol 7-8%, 1.3- butanediol 6-7%, glycyrrhizin 0.4-0.8%, zinc gluconate 0.2-0.3%, Glycogen 2-4%, activity extract 18-22%, beta glucan 1.5-2.3%, Sodium Hyaluronate 0.07-0.09%, hydrolytic collagen 0.3-0.7%, compound amino acid 2-2.7%, biotin 0.1-0.4%, copper peptide 0.04-0.08%, surplus are water.

3. scalp injury according to claim 1 repairs Essence, it is characterised in that: the component of the activity extract and The weight percent of each component are as follows: shaddock fruit extracting solution 3-5%, yeast extract 3-5%, loquat leaf extract 3-5%, horse chestnut Extracting solution 3-5%, centella asiatica extract 3-5%.

4. scalp injury according to claim 3 repairs Essence, it is characterised in that: the component of the activity extract and The weight percent of each component are as follows: shaddock fruit extracting solution 4%, yeast extract 4%, loquat leaf extract 5%, horse chestnut extracting solution 5%, centella asiatica extract 3%.

5. the preparation method that a kind of scalp injury repairs Essence, it is characterised in that: the preparation method the following steps are included:

Step 1: the water of formula ratio, glycerol, 1.3- butanediol, Sodium Hyaluronate are added in agitated kettle and are mixed, then to stirring It mixes glycyrrhizin, zinc gluconate and the glycogen that formula ratio is added in pot and is stirred, be warming up to 70 DEG C -75 DEG C, make to stir Pot in dissolution of raw material it is complete, keep the temperature 10-15min after be cooled to 40 DEG C -45 DEG C it is spare；

Step 2: successively by the activity extract of formula ratio, beta glucan, hydrolytic collagen, compound amino acid, biotin, copper peptide It is added in agitated kettle, stirs and evenly mixs；

Step 3: discharging, filling, packaging are got product after the assay was approved.