CN110200837B - Hair growth composition - Google Patents
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- CN110200837B CN110200837B CN201910535300.2A CN201910535300A CN110200837B CN 110200837 B CN110200837 B CN 110200837B CN 201910535300 A CN201910535300 A CN 201910535300A CN 110200837 B CN110200837 B CN 110200837B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention provides a hair growth composition which comprises the following raw materials in parts by mass: 15-30 parts of hydrolyzed hyaluronic acid, 15-20 parts of centella asiatica extract, 210-50 parts of procyanidine B and 5-10 parts of ceruloplasmin; the molecular weight of the hydrolyzed hyaluronic acid is 8K-10 KDa; the mass ratio of the copper-coated peptide to the anthocyanin B2 is 1: 1-10. The hair growth composition disclosed by the invention can mildly remove dandruff, inhibit grease secretion and balance scalp biological flora, and can inhibit alopecia, repair hair follicles and stimulate new hair growth under the combined action of several substances.
Description
Technical Field
The invention belongs to the field of cosmetics, relates to a hair growth composition, and particularly relates to a composition containing centella extract, procyanidine B2, ceruloplasmin and hydrolyzed hyaluronic acid.
Background
Alopecia is a common disease and a frequently encountered disease in dermatology, except alopecia, patients often have symptoms of scalp pruritus, dandruff increase and the like, and daily life and work are seriously affected. And the personal appearance is affected regardless of sex and age, which affects the mental health of the patient over time. The causes of alopecia are complex and diverse, and can be roughly classified into the following categories: mental factors such as excessive mental stress and excessive nervous tension; sex hormone secretion imbalance or genetic factors; taking side effect factors of immunosuppressant, chemotherapy medicine, etc.; dietary bias, dyspepsia and other nutritional metabolism factors; physical or chemical factors such as environmental pollution and radioactive damage; the factors of the individual life such as alcoholism, staying up all night, inattention to hygiene and the like.
At present, western medicine has been mainly used for treating alopecia by using hormone regulators and biological response regulators. The hormone regulator includes androgen blocking agent and estrogen mediating agent, and the biological response regulator includes minoxidil, tretinoin acid, etc. The treatment method of the traditional Chinese medicine for the alopecia mainly comprises the steps of giving different treatment methods and medicines according to different symptoms of the alopecia, mainly taking Liuwei Dihuang pills and Sijunzi decoction for patients with liver and kidney deficiency, and mainly taking Xiaoyao powder for liver qi stagnation. The treatment methods of the traditional Chinese medicine and the western medicine are respectively long and short. The western medicine treatment method can control alopecia and even grow hair in a short time, but rebound situation is easy to occur after medicine withdrawal, and the side effect of the medicine can not be avoided after long-term use; the Chinese medicine treatment method has the advantages of different judgment of physical signs, long conditioning period and slow response time, and is often suitable to be used as a prevention method. At present, a class of anti-drop products mainly based on the concept of removing dandruff and controlling oil exist in the market, and part of the products are excessively clean and have large irritation to the scalp, so that the result of overusing is brought. Some products, while capable of enhancing hair follicle activity, can only form sparse villous hair in the area of primary hair loss, have poor growth ability and cannot grow into normal hair.
Disclosure of Invention
Aiming at the problems of large side effect, poor effect and the like of the existing cosmetics with the functions of growing and preventing hair loss, the invention provides the hair-growing composition which has obvious hair-growing effect, can solve the problems that active substances and nutrient substances are difficult to be absorbed by scalp, cannot fully exert the effect and the like, and has no side effect and obvious effect.
In order to achieve the purpose, the invention adopts the following technical scheme.
A hair growth composition comprises the following raw materials in parts by weight:
15-30 parts of hydrolyzed hyaluronic acid,
15-20 parts of a centella asiatica extract,
210-50 parts of procyanidine B, namely,
5-10 parts of copper peptide.
The hydrolyzed hyaluronic acid is selected from at least one of hydrolyzed hyaluronic acid or salt thereof, and the molecular weight of the hydrolyzed hyaluronic acid is 8KDa-10 KDa. The hydrolyzed hyaluronate can be sodium salt, potassium salt and other salts acceptable in cosmetics.
The mass ratio of the ceruloplasmin to the procyanidine B2 is 1:1-10, preferably 1:2-8, and most preferably 1: 4.
The centella asiatica extract is specifically centella asiatica extract powder with the purity of more than 95%, and the effective components of the centella asiatica extract powder consist of asiaticoside, asiatic acid, madecassoside and madecassic acid.
The purity of the procyanidin B2 is not less than 95%.
The hair growth promoting composition may also comprise other active substances for treating and preventing alopecia, such as vitamins and their derivatives, selenium-containing compounds or extract, copper-containing or zinc-containing compounds, antioxidant plant extract, hydrolyzed protein or oligopeptide, bactericide, etc.
The hair growth promoting composition may also include other adjuvants, such as humectant, antiseptic, pH regulator, surfactant, viscosity regulator, perfume, and pigment. The humectant is selected from one or more of but not limited to glycerin, sorbitol, betaine, allantoin, acetyl chitosamine, beta-glucan and sodium polyglutamate. The preservative is selected from one or more of pentanediol, phenoxyethanol, chlorobutanol, p-hydroxyacetophenone, quaternary ammonium salts and biguanides. The pH regulator is selected from one or more of citric acid, sodium hydroxide, triethanolamine and aminobenzyl alcohol. The surfactant is selected from one or more of AES ammonium salt, K12 ammonium salt, ammonium laureth sulfate, sodium laureth sulfate and cocamidopropyl betaine. The viscosity regulator is selected from one or more of sodium chloride, ammonium chloride, cocamide betaines, xanthan gum and acrylate. The preservative is selected from one or more of pentanediol, phenoxyethanol, chlorobutanol, p-hydroxyacetophenone, quaternary ammonium salts and biguanides. The pH regulator is selected from one or more of citric acid, sodium hydroxide, triethanolamine and aminobenzyl alcohol.
Preferably, the hair growth composition contains a humectant.
A cosmetic containing the composition for promoting hair growth is provided. The cosmetics include but are not limited to essence, shampoo, cream, emulsion, and hair conditioner.
The content of the hair growth composition in the cosmetic is 0.01-5 wt%. Preferably, the addition amount of the hair growth composition in the essence can be 0.1-3 wt%; the shampoo can be added in an amount of 0.01-2 wt%; the addition amount of the cream can be 0.05-2 wt%.
The invention has the following advantages:
the hair growth composition disclosed by the invention can mildly remove dandruff, inhibit grease secretion and balance scalp biological flora, and can inhibit alopecia, repair hair follicles and stimulate new hair growth under the combined action of several substances. The centella asiatica extract and the hydrolyzed hyaluronic acid can repair damaged hair follicles, relieve and reduce the stimulation of external harmful substances to the scalp; the bluecopper peptides and the procyanidine B2 are used as important factors for assisting damaged scalp tissues to resist inflammatory reaction, can reduce proinflammatory cytokines such as IL-6 and the like, reduce problems of scalp itching, redness and swelling, stabbing pain and the like caused by inflammation, provide a balanced and healthy internal environment for subsequent hair growth, and simultaneously can accelerate microcirculation of scalp capillaries, promote cell activation and regeneration together with a centella extract, repair collagen lost in vivo and enhance hair follicle functions. In particular, procyanidin B2 can improve permeability of capillary, promote cell metabolism, enhance absorption of active substances or nutrients, and promote hair follicle regeneration together with hydrolyzed hyaluronic acid.
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FIG. 1 is a comparison of the results before and after use of the sample prepared in example 4.
Detailed Description
The present invention will be further illustrated with reference to the following examples, but the present invention is not limited to the following examples.
EXAMPLE 1 anti-inflammatory Effect of different ratios of blue copper peptide and procyanidin B2
Preparing the ceruloplasmin and the procyanidine B2 into solutions with the total content of 1, 2, 5, 10 and 20 mu g/mL by using culture solutions according to the mass ratio of 1:0, 0:1, 4:1, 2:1, 1:2, 1:4, 1:8 and 1:10, and filtering and sterilizing the solutions for later use. Using log phase 3T3 mouse embryo fibroblast as test material, adding into 96-well culture plate, adding 0.1mL per well with density of 1 × 105Culturing each/mL cell suspension until the cell suspension is adherent, removing the culture solution, adding 0.1mL of Lipopolysaccharide (LPS) physiological saline solution or physiological saline (blank control) with the concentration of 1 mu g/mL, respectively adding 0.1mL of prepared bluecopper peptide and procyanidine B2 solution, taking the LPS alone as a positive control, culturing for 24h, sucking the culture solution, centrifuging, taking the supernatant, performing ELISA (enzyme-linked immunosorbent assay) to detect the content (pg/mL) of inflammatory factor IL-6 in the supernatant of the culture solution, treating 5 duplicate wells, and calculating the inhibition rate according to the following formula:
the Combination Index (CI) was calculated using CompnSyn software based on inhibition, with strong synergy when CI <0.4, high synergy when CI <0.6 > 0.4, medium synergy when CI <0.8 > 0.6, and mild synergy when CI <0.9 > 0.8, the results are shown in Table 1:
TABLE 1 influence of bluecopper peptides and procyanidins on the inflammatory factor IL-6
As can be seen from the data in Table 1, when the ratio of the ceruloplasmin to the procyanidine B2 is 1:1-10, the CI indexes of Fa =0.5 are both 0.9 and above, and the synergistic effect is achieved; when the ratio of the copper-coated peptides to the procyanidine B2 is 1:1-8, the CI indexes of Fa =0.75 are both 0.9 and above, and the synergistic effect is achieved; when the ratio of the copper-coated peptides to the procyanidine B2 is 1:2-8, the CI indexes of Fa =0.9 are both 0.9 and above, and the synergistic effect is achieved; particularly, when the ratio of the ceruloplasmin to the procyanidine B2 is 1:4, the CI indexes are both less than 0.6, the high synergy is achieved, and the strong synergy is achieved.
Example 2 preparation of Hair growth compositions
Weighing the following raw materials in proportion:
EXAMPLE 3 healing Effect
The hair growth promoting composition of example 2 was prepared as a 2% solution in a culture medium, and filtered and sterilized for use. Taking L929 mouse fibroblast as a test material, adding 0.1mL of cell with the density of 5 multiplied by 10 into a 96-well culture plate4Adding 0.1mL of different hair growth composition solutions into each mL of L929 cell suspension, continuously culturing the cells for 24h, taking the hole only added with the culture solution as a blank control and the hole only added with the cell suspension as a negative control, measuring the absorbance value by adopting an MTT method for every 5 treated multiple holes, and calculating the cell proliferation rate according to the following formula:
TABLE 2 Effect on cell proliferation Rate
As can be seen from the data in table 2, compared with the hair growth composition without adding hydrolyzed hyaluronic acid and centella asiatica extract, the hair growth composition with hydrolyzed hyaluronic acid or centella asiatica extract added alone has a certain effect of promoting cell proliferation, and the hair growth composition with the two components can obviously promote cell proliferation.
Example 4 preparation of essence containing Hair growth composition
The essence is prepared from the following raw materials in percentage by mass:
2.5% of hair growth promoting composition No. 1 in example 2, 3% of glycerol, 2% of sorbitol, 2% of betaine, 0.05% of allantoin, 0.5% of acetyl chitosamine, 0.8% of beta-glucan, 0.2% of sodium polyglutamate, 0.6% of phenoxyethanol, and water to make up to 100%;
the preparation method comprises the following steps:
adding water into the hair growth combination group, stirring and dissolving, adding sorbitol, betaine, allantoin, acetyl chitosamine, beta-glucan and sodium polyglutamate, stirring and dissolving, adding phenoxyethanol, finally supplementing water, stirring uniformly, standing for 6h, and discharging.
Comparative example 1
Raw materials are weighed according to the formula in preparation E in US 5538945: 2.5 percent (w/w) of bluecopper peptide, 2 percent (w/w) of hydroxypropyl cellulose, 20 percent (w/w) of glycerol, 803 percent (w/w) of tween-and 72.5 percent (w/w) of sterile water; then, dissolving the raw materials in water to prepare a hair growth liquid; as nonoxynol-9 as a surfactant in the original patent has stronger cell membrane toxicity, the nonoxynol-9 is changed into tween-80.
Comparative example 2
Weighing raw materials according to the proportion of 3 percent of glycerol, 2 percent of sorbitol, 2 percent of betaine, 0.05 percent of allantoin, 0.5 percent of acetyl chitosamine, 0.8 percent of beta-glucan, 0.2 percent of sodium polyglutamate, 0.6 percent of phenoxyethanol and water to 100 percent, and dissolving the raw materials in the water to obtain the product.
EXAMPLE 5 Hair growth Effect of different products
The different solutions prepared in example 4, comparative example 1 and comparative example 2 were subjected to one-year-round observation of the effect of 60 patients with alopecia between 30 and 55 years (male-female ratio of 5: 1), and randomly divided into 3 groups: the blank set of comparative example 2 was used, the sample set of the samples from example 4 was used, and the comparative set of the samples from comparative example 1 was used. The medicine is applied once in the morning and at night every day, and 5mL of the medicine is applied each time; the conditions of the scalp and hair of the patients of the comparative group and the example group were observed from the three aspects of hair growth effect, oil control effect, and dandruff removal effect at different times, respectively, and the results are shown in tables 3 to 5; example 4 comparative pictures before and after use are shown in figure 1.
TABLE 3 Hair growth promoting effect of different products
TABLE 4 oil control Effect of different products
TABLE 5 antidandruff Effect of different products
It can be seen from table 3 that 10 cases of example 4 developed stubble at two months, 2 cases of comparative example 1 and no comparative example 2, indicating that example 4 had a good hair growth effect and stimulated new hair to grow rapidly. As can be seen from the results of 3 months, 6 months and 1 year, comparative example 1 stimulates new hair growth, but has a poor effect of stimulating hair growth; in example 4, as shown in fig. 1, after 6 months of use, new hair grows out of the original alopecia area, the hair becomes thick obviously, the hair quality is the same as that of other areas, and the hair grows normally; the invention can promote the growth of hair, and the growth of new hair is the same as that of other parts. This shows that under the combined action of several substances, the composition of the present invention can effectively repair hair follicles, enhance the absorption of active substances or nutrients by hairs, and stimulate new hair growth.
It can be seen from table 4 that at 2 months, there are 12 cases of scalp oil secretion in example 4 and 6 cases in comparative example 1 and none in comparative example 2, which indicates that the oil control effect of example 4 is better, and as can be seen from the results of 3 months, 6 months and 1 year, the present invention can not only improve the condition of excessive scalp oil secretion, but also has a significant inhibitory effect on scalp oil secretion, indicating that several substances in the composition of the present invention assist scalp tissue to fight inflammatory response and provide a balanced and healthy internal environment.
It can be seen from table 5 that at 2 months, 9 cases of example 4 have reduced itching, while 7 cases of comparative example 1 have and 7 cases of comparative example 2 do not have, indicating that example 4 has a good effect of suppressing itching, and that the present invention not only can reduce itching, but also suppress the production of dandruff, as can be seen from the results of 3 months, 6 months and 1 year, indicating that several substances in the composition of the present invention assist the balance metabolism of scalp tissues and suppress the production of dandruff.
Example 6 shampoo containing Hair growth composition
Preparing shampoo according to the following raw materials in percentage by mass:
example 2, hair growth promoting composition No. 1 2.5%, sodium laureth sulfate 30%, cocamide MEA 15%, glycerol 3%, guar gum hydroxypropyl trimonium chloride 0.5%, methylisothiazolinone 0.03%, zinc pyrithione 3%, essence 0.05%, water make up to 100%;
the preparation method comprises the following steps:
adding water into a stirring kettle, heating to 75-85 ℃, sequentially adding sodium laureth sulfate, cocamide MEA, glycerol and guar gum hydroxypropyl trimethyl ammonium chloride, then cooling to 45-55 ℃, sequentially adding the hair growth composition, methylisothiazolinone, zinc pyrithione and essence, and uniformly stirring to form a solution.
Example 7 Hair conditioner containing Hair growth composition
Preparing the hair conditioner according to the following raw materials in percentage by mass:
example 2, hair growth promoting composition No. 1 2.5%, stearyl alcohol 5%, cetyl ethyl hexanoate 10%, behenyl trimethyl ammonium chloride 3%, fatty alcohol polyoxyethylene ether 5%, chamomile extract 1%, white willow bark extract 1%, methylisothiazolinone 0.03%, essence 0.05%, water to 100%;
the preparation method comprises the following steps:
adding water into a stirring kettle, heating to 75-85 ℃, sequentially adding stearyl alcohol, cetyl ethyl hexanoate, behenyl trimethyl ammonium chloride and fatty alcohol-polyoxyethylene ether, then cooling to 45-55 ℃, sequentially adding the hair growth composition, the chamomile extract, the white willow bark extract and the methylisothiazolinone, and the essence, and uniformly stirring to form a solution, thus obtaining the hair growth promoting composition.
Claims (9)
1. The hair growth composition is characterized by comprising the following raw materials in parts by mass:
15-30 parts of hydrolyzed hyaluronic acid,
15-20 parts of a centella asiatica extract,
210-50 parts of procyanidine B, namely,
5-10 parts of copper peptide;
the mass ratio of the ceruloplasmin to the procyanidine B2 is 1: 1-10.
2. The hair growth composition according to claim 1, wherein the hydrolyzed hyaluronic acid is at least one selected from the group consisting of hydrolyzed hyaluronic acid or a salt thereof, and has a molecular weight of 8KDa to 10 KDa.
3. The hair growth composition according to claim 1, wherein the mass ratio of the blue copper peptide to the procyanidin B2 is 1: 2-8.
4. The hair growth composition according to claim 1, wherein the mass ratio of the ceruloplasmin to the procyanidin B2 is 1: 4.
5. The hair growth composition according to claim 1, further comprising other active substances for treating and preventing hair loss.
6. Hair growth composition according to claim 5, characterized in that said active substance is selected from one or more of vitamins and derivatives thereof, selenium-containing compounds or extracts, copper-or zinc-containing compounds, antioxidant plant extracts, hydrolysed proteins or oligopeptides and bactericides.
7. A cosmetic comprising the hair growth promoting composition according to any one of claims 1 to 6.
8. The cosmetic according to claim 7, wherein the cosmetic is a serum, a shampoo, a cream, a lotion or a conditioner.
9. The cosmetic according to claim 7, wherein the hair growth promoting composition is contained in the cosmetic in an amount of 0.01 to 5 wt%.
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| CN113318043A (en) * | 2021-05-21 | 2021-08-31 | 广州市涵美化妆品有限公司 | Essence with effects of fixing hair and growing hair and preparation method thereof |
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| CN115501134B (en) * | 2022-09-27 | 2024-06-21 | 华熙生物科技股份有限公司 | Cosmetic composition containing blue copper peptide |
| CN115517997B (en) * | 2022-09-27 | 2024-01-23 | 浙江湃肽生物股份有限公司 | Cosmetic composition, and preparation method and application thereof |
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| CN109674686A (en) * | 2019-01-22 | 2019-04-26 | 华熙福瑞达生物医药有限公司 | A kind of composition and preparation method thereof of maintenance damaged skin |
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