CN107625825B - Anti-frost crack paste and preparation method thereof - Google Patents
Anti-frost crack paste and preparation method thereof Download PDFInfo
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- CN107625825B CN107625825B CN201710819029.6A CN201710819029A CN107625825B CN 107625825 B CN107625825 B CN 107625825B CN 201710819029 A CN201710819029 A CN 201710819029A CN 107625825 B CN107625825 B CN 107625825B
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Abstract
The invention provides an anti-frost crack paste which is prepared from the following components in parts by weight: 1-3 parts of folium artemisiae argyi essential oil, 2-5 parts of lemon peel essential oil, 10-16 parts of an emulsifier, 15-25 parts of water, 15-20 parts of vaseline, 5-10 parts of animal oil, 0.5-1 part of a preservative and 2-4 parts of a humectant. The invention also provides a preparation method of the frost crack prevention paste. The frost crack prevention cream provided by the invention has good frost crack prevention, detumescence and anti-inflammation, anti-allergy effects and cold resistance stability.
Description
Technical Field
The invention relates to an anti-frost crack paste and a preparation method thereof.
Background
Chilblain and chap both belong to physical skin diseases, the chilblain usually occurs at exposed parts of fingers, toes, ears, noses and the like, and purple spots, edema and inflammation appear after being affected by low-temperature cold, itching occurs when people feel hot, serious blistering and ulcer pain occur, the chilblain is easy to frequently occur in cold seasons in winter, the chilblain is improved along with the warm seasons, but the chilblain is easy to recur in winter. Chap refers to cracks with different depths which occur in skin parts such as fingers, toes, palms, heels and the like, is a skin disease of dry skin and linear cracks caused by various reasons, is a common frequently-occurring skin disease, and is common in autumn and winter.
Chinese patent application CN201710165265.0 discloses a frost crack nano-emulsifiable paste, which belongs to the technical field of preparation and production of modern nano-emulsifiable pastes for traditional Chinese medicine cosmetics and consists of a puffball pit viper oil, a safflower notoginseng, a cinnamon gromwell, an apricot glue gallnut, a cassia twig red sage root, a cocklebur fruit and a clematis root natural plant nano-emulsifiable paste. The invention can not effectively exert the frost crack prevention effect and has poor cold resistance and stability.
Disclosure of Invention
The invention aims to provide the frost crack prevention cream which has good frost crack prevention, detumescence, anti-inflammation, anti-allergy effects and cold-resistant stability.
In order to solve the technical problems, the technical scheme of the invention is as follows:
the anti-frost crack paste is prepared from the following components in parts by weight: 1-3 parts of folium artemisiae argyi essential oil, 2-5 parts of lemon peel essential oil, 10-16 parts of an emulsifier, 15-25 parts of water, 15-20 parts of vaseline, 5-10 parts of animal oil, 0.5-1 part of a preservative and 2-4 parts of a humectant.
Further, the preparation steps of the argy wormwood leaf essential oil are as follows:
drying folium Artemisiae Argyi, pulverizing to 50 mesh to obtain folium Artemisiae Argyi powder, adding folium Artemisiae Argyi powder into ultrapure water at a solid-to-liquid ratio of 1:18g/m L, soaking for 4 hr, placing in a fractionating device, electrically heating to reflux temperature, extracting for 3 hr by steam distillation, and dehydrating the obtained extract with anhydrous sodium sulfate to obtain folium Artemisiae Argyi essential oil.
Further, the preparation steps of the essential oil of the lime peel are as follows:
placing the peel of lime into a vacuum freezer for drying for 10 hours, taking out the peel of lime, crushing the peel of lime into 50 meshes to obtain peel powder of lime, adding the peel powder of lime into an extraction kettle, opening a carbon dioxide steel cylinder, blowing air at the flow rate of 20L/h until the pressure reaches 25MPa, heating the mixture to 45 ℃, and performing supercritical extraction for 1.5 hours to obtain the peel essential oil of lime.
Further, the emulsifier is formed by mixing ceteareth-25 and mannitol erythritol ester in a weight ratio of 3: 1.
Further, the water is deionized water.
Further, the petrolatum is white petrolatum.
Further, the animal oil is mutton fat.
Further, the preservative is sorbic acid.
Further, the humectant is propylene glycol.
The invention also provides a preparation method of the anti-frost cracking paste.
In order to solve the technical problems, the technical scheme is as follows:
the preparation method of the anti-frost crack paste comprises the following steps:
(1) weighing the components according to the weight parts, uniformly mixing vaseline, an emulsifier and water, placing the mixture into a homogenizing mixer, heating to 70-80 ℃, stirring at the rotating speed of 1500rpm for 3 minutes, and then transferring the mixture into a high-pressure micro-jet homogenizer to homogenize for 3 times under the pressure of 10kbar to prepare mixed emulsion;
(2) heating and melting animal oil, adding the animal oil into the mixed emulsion prepared in the step (1), stirring until the mixture is uniformly mixed, cooling to below 50 ℃, adding the folium artemisiae argyi essential oil, the lime peel essential oil, the preservative and the humectant, continuously stirring until the mixture is uniformly mixed, and cooling to form paste at room temperature to obtain the frost crack prevention paste.
Compared with the prior art, the invention has the following beneficial effects:
1) the folium artemisiae argyi is the leaf of the folium artemisiae argyi of artemisia of Compositae, is rich in active ingredients such as polysaccharide, flavone, tannin, etc., the invention prepares folium artemisiae argyi essential oil through steam distillation with folium artemisiae argyi, it can relieve chilblain and its symptom caused effectively in short time, can play a role in healing and promoting granulation in short time to chapped skin, therefore have very good effects of preventing frostbite and splitting, folium artemisiae argyi essential oil has very good effects of subsiding swelling and resisting inflammation in addition.
2) The lemon peel is the peel part of the lime, and the oily active ingredients in the lemon peel are extracted by a supercritical carbon dioxide extraction method to obtain the lemon peel essential oil which has good anti-inflammatory and anti-swelling activities, so that the swelling and anti-inflammatory effects of the frost crack prevention cream can be further improved; in addition, the essential oil of the lime peel also has good antiallergic activity and excellent cold resistance, so that the antiallergic effect and the cold resistance stability of the frost crack prevention paste can be effectively improved.
3) The mannitose erythritol ester is a natural surfactant and has good emulsifying property and cold resistance, so that the cold resistance stability of the frost crack prevention paste can be further improved, and the frost crack prevention paste can also exert the effect for a long time in a cold environment; in addition, the mannitol erythritol ester has antibacterial and bacteriostatic activity, and can effectively prevent the skin from being influenced by an allergen, so that the antiallergic effect of the frost crack prevention cream can be further improved.
Detailed Description
The present invention will be described in detail with reference to specific embodiments, and the exemplary embodiments and descriptions thereof herein are provided to explain the present invention but not to limit the present invention.
Examples 1 to 4
The frost crack prevention paste was prepared according to the proportions (in parts by weight) of table 1:
| example 1 | Example 2 | Example 3 | Example 4 | |
| Folium artemisiae argyi essential oil | 1 | 3 | 2 | 2.5 |
| Essential oil of lime peel | 3 | 2 | 4 | 5 |
| Ceteareth-25 | 7.5 | 10.5 | 9 | 12 |
| Mannose erythroseAlcohol esters | 2.5 | 3.5 | 3 | 4 |
| Deionized water | 18 | 25 | 20 | 15 |
| White vaseline | 15 | 16 | 18 | 20 |
| Mutton fat | 10 | 9 | 8 | 5 |
| Sorbic acid | 1 | 0.5 | 0.8 | 0.9 |
| Propylene glycol | 2.5 | 2 | 3 | 4 |
TABLE 1
The preparation process of examples 1-4 comprises the following steps:
(1) drying folium Artemisiae Argyi, pulverizing to 50 mesh to obtain folium Artemisiae Argyi powder, adding folium Artemisiae Argyi powder into ultrapure water at a solid-to-liquid ratio of 1:18g/m L, soaking for 4 hr, placing in a fractionating device, electrically heating to reflux temperature, extracting for 3 hr by steam distillation, and dehydrating the obtained extract with anhydrous sodium sulfate to obtain folium Artemisiae Argyi essential oil;
(2) placing lime peel in a vacuum freezer for drying for 10 hours, taking out the lime peel, crushing the dried lime peel into 50 meshes to obtain lime peel powder, adding the lime peel powder into an extraction kettle, opening a carbon dioxide steel cylinder, feeding air at the flow rate of 20L/h until the pressure reaches 25MPa, heating to 45 ℃, and performing supercritical extraction for 1.5 hours to obtain lime peel essential oil;
(3) weighing the components according to the parts by weight, uniformly mixing white vaseline, an emulsifier formed by mixing ceteareth-25 and mannitol erythritol ester according to the weight ratio of 3:1 and deionized water, placing the mixture in a homogenizing mixer, heating to 70-80 ℃, stirring at the rotating speed of 1500rpm for 3 minutes, and then transferring the mixture into a high-pressure micro-jet homogenizer for homogenizing for 3 times under the pressure of 10kbar to prepare mixed emulsion;
(4) heating and melting mutton fat, adding the mutton fat into the mixed emulsion prepared in the step (1), stirring until the mixture is uniformly mixed, cooling to below 50 ℃, adding the argy wormwood leaf essential oil, the lime bark essential oil, the sorbic acid and the propylene glycol, continuously stirring until the mixture is uniformly mixed, and cooling to form paste at room temperature to obtain the frost cracking prevention paste.
Reference example 1
The components do not contain argy wormwood leaf essential oil, and other components and preparation methods are the same as those in example 3.
Reference example 2
The ingredients do not include essential oil of lime peel, and other ingredients and preparation methods are the same as those of example 3.
Reference example 3
The components do not include mannitol erythritol ester, and other components and preparation methods are the same as those of example 3.
Comparative example
The comparative example is example 1 of chinese patent application No. CN 201710165265.0.
The first experimental example: frost crack prevention efficacy test
100 chilblain chapped patients are selected, the chilblain chapped patients are smeared on affected parts for 1 time before falling asleep every day, after two weeks, each person evaluates the chilblain chapped effect, 1 minute shows that the chilblain is hardly effective, 2 minutes shows that the chilblain is relieved, the chapped parts are partially healed, 3 minutes shows that the chilblain is disappeared, the chapped parts are healed, the average score of the chilblain chapped effect is calculated, and the test results are shown in table 2:
| mean split freezing prevention effect | |
| Example 1 | 2.7 |
| Example 2 | 2.7 |
| Example 3 | 2.8 |
| Example 4 | 2.7 |
| Reference example 1 | 0.5 |
| Reference example 2 | 2.7 |
| Reference example 3 | 2.6 |
| Comparative example | 2.0 |
TABLE 2
As can be seen from Table 2, the average anti-freeze-cracking effects of the examples 1-4 of the present invention are much higher than those of the comparative examples, indicating that the present invention has very good anti-freeze-cracking effects, of which the anti-freeze-cracking effect of example 3 is the best. The parts of the components of reference examples 1-3 are different from those of example 3, wherein the average freezing crack prevention effect of reference example 1 is reduced to the maximum extent, which shows that the effect of the argy wormwood leaf essential oil on the freezing crack prevention effect is very large; the average anti-freeze-cracking effect of the reference examples 2 and 3 is equal to that of the examples 1 to 4, which shows that the essential oil of the lime peel and the mannitol erythritol ester have no influence on the anti-freeze-cracking effect.
Experiment example two: detumescence anti-inflammatory efficacy test
Selecting 100 subjects with swelling and inflammation on skin, applying the frost crack prevention ointment to the affected part for 1 time every day, observing the condition of the affected part after 5 days, calculating the effective rate of swelling and inflammation, wherein the effective rate of swelling and inflammation is × 100% of effective number of swelling and inflammation/total number of people, and the test results are shown in table 3:
| effective rate of detumescence and anti-inflammation (%) | |
| Example 1 | 89 |
| Example 2 | 90 |
| Example 3 | 91 |
| Example 4 | 88 |
| Reference example 1 | 76 |
| Reference example 2 | 78 |
| Reference example 3 | 89 |
| Comparative example | 32 |
TABLE 3
As can be seen from Table 3, the effective swelling-reducing and anti-inflammatory rates of the examples 1 to 4 of the present invention are much higher than those of the comparative examples, which indicates that the present invention has very good swelling-reducing and anti-inflammatory effects, wherein the swelling-reducing and anti-inflammatory effects of the example 3 are the best. The components of reference examples 1-3 are different from those of example 3, the effective swelling-reducing and anti-inflammatory rates of reference examples 1 and 2 are reduced slightly, which shows that the essential oil of argy wormwood leaf and the essential oil of lime bark can effectively improve the effects of swelling reduction and anti-inflammatory; the effective rate of detumescence and anti-inflammation of the reference example 3 is equal to that of the examples 1 to 4, which shows that the mannitol erythritol ester has no influence on the detumescence and anti-inflammation effects.
Experiment example three: antiallergic efficacy test
Selecting 100 subjects with skin allergy symptoms, applying the frost crack prevention cream to the affected part for 1 time every day, observing the condition of the affected part after 5 days, and calculating the anti-allergy effective rate, wherein the anti-allergy effective rate is × 100% of the number of effective anti-allergy people/the total number of people, and the test results are shown in table 4:
| effective antiallergic rate (%) | |
| Example 1 | 89 |
| Example 2 | 88 |
| Example 3 | 90 |
| Example 4 | 87 |
| Reference example 1 | 89 |
| Reference example 2 | 70 |
| Reference example 3 | 74 |
| Comparative example | 16 |
TABLE 4
As can be seen from Table 4, the anti-allergic effective rates of the examples 1-4 of the present invention are much higher than those of the comparative examples, which indicates that the present invention has very good anti-allergic effects, wherein the anti-allergic effect of the example 3 is the best. The parts of the components of the reference examples 1-3 are different from those of the example 3, the antiallergic effective rate of the reference example 1 is equal to that of the examples 1-4, and the antiallergic effect of the folium artemisiae argyi essential oil is basically not influenced; the antiallergic effective rates of the reference examples 2 and 3 are reduced slightly, which shows that the essential oil of lime peel and the mannitol erythritol ester can effectively improve the antiallergic effect.
Experimental example four: cold resistance stability test
Each frost cracking prevention paste is placed in a room with the temperature of-10 ℃, taken out after 24 hours, naturally recovered to the room temperature, and then the surface change of the frost cracking prevention paste is observed, and the test results are shown in table 5:
| example 1 | No obvious difference on the surface |
| Example 2 | No obvious difference on the surface |
| Example 3 | No obvious difference on the surface |
| Example 4 | No obvious difference on the surface |
| Reference example 1 | No obvious difference on the surface |
| Reference example 2 | The surface of the product has caking phenomenon and can not be directly used |
| Reference example 3 | The surface of the product has caking phenomenon and can not be directly used |
| Comparative example | The surface of the material is cakedPhenomenon that it cannot be used directly |
TABLE 5
As can be seen from Table 5, examples 1 to 4 of the present invention all had better cold stability than the comparative examples. Reference examples 1-3 differ from example 3 in a part of their components, wherein reference example 1 has cold stability comparable to examples 1-4, indicating that essential oil of argy wormwood leaves has substantially no effect on cold stability; the cold resistance stability of the reference examples 2 and 3 is as poor as that of the comparative example, which shows that the essential oil of the lime peel and the mannitol erythritol ester can effectively improve the cold resistance stability.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (8)
1. The frost crack prevention paste is characterized in that: the composition is prepared from the following components in parts by weight: 1-3 parts of folium artemisiae argyi essential oil, 2-5 parts of lemon peel essential oil, 10-16 parts of an emulsifier, 15-25 parts of water, 15-20 parts of vaseline, 5-10 parts of animal oil, 0.5-1 part of a preservative and 2-4 parts of a humectant;
the preparation steps of the folium artemisiae argyi essential oil are as follows:
drying folium Artemisiae Argyi, pulverizing to 50 mesh to obtain folium Artemisiae Argyi powder, adding folium Artemisiae Argyi powder into ultrapure water at a solid-to-liquid ratio of 1:18g/m L, soaking for 4 hr, placing in a fractionating device, electrically heating to reflux temperature, extracting for 3 hr by steam distillation, and dehydrating the obtained extract with anhydrous sodium sulfate to obtain folium Artemisiae Argyi essential oil;
the preparation method of the lime peel essential oil comprises the following steps:
placing the peel of lime into a vacuum freezer for drying for 10 hours, taking out the peel of lime, crushing the peel of lime into 50 meshes to obtain peel powder of lime, adding the peel powder of lime into an extraction kettle, opening a carbon dioxide steel cylinder, blowing air at the flow rate of 20L/h until the pressure reaches 25MPa, heating the mixture to 45 ℃, and performing supercritical extraction for 1.5 hours to obtain the peel essential oil of lime.
2. The frost crack prevention paste of claim 1, wherein: the emulsifier is formed by mixing ceteareth-25 and mannitol erythritol ester according to the weight ratio of 3: 1.
3. The frost crack prevention paste according to claim 2, wherein: the water is deionized water.
4. The anti-frost crack paste of claim 3, wherein: the vaseline is white vaseline.
5. The anti-frost crack paste of claim 4, wherein: the animal oil is mutton fat.
6. The frost crack prevention paste of claim 5, wherein: the preservative is sorbic acid.
7. The frost crack prevention paste of claim 6, wherein: the humectant is propylene glycol.
8. The method for preparing the frost crack prevention paste according to any one of claims 1 to 7, wherein the frost crack prevention paste comprises the following components: the method comprises the following steps:
(1) weighing the components according to the weight parts, uniformly mixing vaseline, an emulsifier and water, placing the mixture into a homogenizing mixer, heating to 70-80 ℃, stirring at the rotating speed of 1500rpm for 3 minutes, and then transferring the mixture into a high-pressure micro-jet homogenizer to homogenize for 3 times under the pressure of 10kbar to prepare mixed emulsion;
(2) heating and melting animal oil, adding the animal oil into the mixed emulsion prepared in the step (1), stirring until the mixture is uniformly mixed, cooling to below 50 ℃, adding the folium artemisiae argyi essential oil, the lime peel essential oil, the preservative and the humectant, continuously stirring until the mixture is uniformly mixed, and cooling to form paste at room temperature to obtain the frost crack prevention paste.
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| CN201710819029.6A CN107625825B (en) | 2017-09-12 | 2017-09-12 | Anti-frost crack paste and preparation method thereof |
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| CN107625825B true CN107625825B (en) | 2020-07-28 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536485A (en) * | 2013-10-18 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Hand cream for preventing chapped skin |
| CN203763364U (en) * | 2014-03-31 | 2014-08-13 | 梅向东 | Medical patch for chilblain prevention and treatment |
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2017
- 2017-09-12 CN CN201710819029.6A patent/CN107625825B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536485A (en) * | 2013-10-18 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Hand cream for preventing chapped skin |
| CN203763364U (en) * | 2014-03-31 | 2014-08-13 | 梅向东 | Medical patch for chilblain prevention and treatment |
Non-Patent Citations (2)
| Title |
|---|
| "冻" 人不美丽;李欣;《课堂内外(初中版)》;20021231(第01期);26 * |
| 橘皮功能多多;无;《双足与保健》;20091231(第04期);21 * |
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