CN108379374A - It is a kind of to be used to treat ointment of pernio and preparation method thereof - Google Patents
It is a kind of to be used to treat ointment of pernio and preparation method thereof Download PDFInfo
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- CN108379374A CN108379374A CN201810520234.7A CN201810520234A CN108379374A CN 108379374 A CN108379374 A CN 108379374A CN 201810520234 A CN201810520234 A CN 201810520234A CN 108379374 A CN108379374 A CN 108379374A
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Abstract
The invention discloses a kind of ointment and preparation method thereof for treating pernio：1) wormwood, Caulis Spatholobi and dried orange peel are ground, extracting solution A is made；2) lotus seeds are pulverized, and cross sieve；3) by phoenix tree leaf and carrot leaf heating concentration, aqueous extract is obtained；4) sesame flower and cactus are smashed to pieces grinding, alcohol extract is made with absolute ethyl alcohol；It adds it in aqueous extract and is mixed, obtain mixed extract B；5) extracting solution A and mixed extract B are mixed, evaporates solvent, obtain extraction medicament C；The lotus seeds pulverized are poured into, medicament D is made；6) by glycerin monostearate, vaseline and medicament D stirrings, white paste is obtained；7) white paste is high-pressure homogeneous to get to target ointment.The medical ointment for treating chilblain of the present invention has the function of antibacterial, clearing and activating the channels and collaterals, hemostasis, removing toxicity for detumescence, repairs skin；And the lotion is fine and smooth, lubricious, non-greasy, it is without any side effects the features such as.
Description
Technical field
The present invention relates to field of medicaments more particularly to a kind of ointment and preparation method thereof for treating pernio.
Background technology
Pernio is common in winter, erythema, the tumidus damage repeatedly of the local skin caused by very cold, severe patient
It may occur in which blister, ulcer, the course of disease is slow, and self-healing after weather turns warm is easily recurred.
The main reason for cold is pernio morbidity, pathogenic factor are that the skin of pernio patient is encountering cold (0~10
DEG C), the moist or changes in temperature sudden turn of events when, local parteriole is shunk, long arteries paralysis and expand, venous congestion, locally
Poor circulation and fall ill.In addition, the humidity of skin of patient itself, tip capilary deformity, autonomic nerve dysfunction,
The factors such as malnutrition, dysendocrinism may also participate in falling ill.Lack movement, acrohyperhidrosis moist, footgear tension and long-term
The factors such as outdoor low operating temperatures can cause the generation of pernio.
Pernio is apt to occur in early winter, early spring, common with children, women and the bad person of peripheral blood circulation, these patients
Be often accompanied by acral body skin send out cool, acrocyanosis, the performances such as hidrosis.Skin lesion is apt to occur in finger, the back of the hand, face, auricle, foot
Toe, foot edge, heel etc., normal both sides distribution.Common damage is the edematous erythema of the congestive dark violet red protuberance of limitation, border
Boundary is unclear, and edge is in cerise, and surface anxiety is glossy, and matter is soft.Part pressing can fade, and red is gradually restored after going pressure.
Blister can occur for severe patient, and rupture forms rotten to the corn or ulcer, retains pigmentation or atrophic scar more afterwards.Gargalesthesia is apparent, meets
Aggravate after heat, pain after festering.
There is a kind of pernio of specific type to be more common in the thigh of women.Clinically there is characteristic in blue red wellability
Spot is symmetrically distributed in the facies lateralis femoris of obesity, can occasionally have secondary ulcer and often merge horny follicular plug.These have been damaged
It is entirely related with cold expoure, and subside in warm environment.
There are three types of specific to the treatment of pernio currently on the market：One, systematic treating：Oral niacinamide, nifedipine etc.
Vasodilator.Or by Radix Salviae Miltiorrhizae (20ml) be added D-40 500ml intravenous infusions, have expansion blood vessel, improve microcirculation,
The effects that increasing blood flow and thrombus dissolving.Two, local treatment：Helium-neon laser and infrared radiation can be used, or makees Perception In Man Before And After Laser photograph
After penetrating (Zusanli, fuliu etc.), pernio partial row is defocused and is generally irradiated.Three, ointment is smeared：Non- ulceration person can externally used compound liver
Plain ointment, hirudiod, vitamin E ointment etc..
For treating three kinds of methods of pernio above, the first application vasodilator systematic treating method not only can band
Carry out many drug side-effects, the symptoms such as dizziness, palpitaition, low blood pressure can be caused.Meanwhile being had to when with such drug cautiously,
Consider age of patient, gender, general status, whether there is or not hypertension, whether there is or not hemorrhagic tendency, pay attention to liver function, prothrombin time,
Whether clotting time and bleeding time and platelet count are normal.Patient's disabling in cerebrovascular accident acute stage.Severe coronary heart disease patients, brain are dynamic
Arteries and veins hardening, glaucoma have hemorrhagic tendency person to use with caution.The treatment of the therapy of second of local irradiation laser, physical therapy has
Shi Jianxiao is little, and has many contraindication needs to avoid.The third smearing ointment, slowly effect, and for suffering from pernio for many years
Patient can not cure completely, the case where often having recurrence.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of ointment and its system for treating pernio
Preparation Method, to solve, existing systematic treating method, physical therapy and smearing medicinal ointment therapy are ineffective, treat specific aim not
By force, the technical problems such as preparation method complexity are improved, and the present invention has the function of antibacterial, clearing and activating the channels and collaterals, can be cured because of part
Pernio caused by poor circulation；And have the function of hemostasis, removing toxicity for detumescence, the bleeding that is open caused by pernio can be cured
And red and swollen symptom；And because substance contains abundant vitamin, minerals and organic acid in formula, has to the skin of frostbite and repair
Multiple effect.The skin for becoming obscure because of pernio can be repaired, affected part skin is made to restore as before；And the lotion is fine and smooth, it is lubricious,
Non-greasy can be used as daily hand lotion and use, while can also play the role of preventing frostbitten, and the ointment is used for a long time without any pair
The features such as effect.
The invention discloses following technical schemes：A kind of ointment for treating pernio, including following raw material components：Chinese mugwort
Grass, phoenix tree leaf, carrot leaf, Caulis Spatholobi, dried orange peel, lotus seeds, sesame flower, cactus, glycerin monostearate and vaseline.
The parts by weight of the above raw material components are：
Further, the parts by weight of the above raw material components are preferably：
Effect of the above raw material each raw material component in the party is as follows:
Wormwood has extraordinary natural antibacterial effect, has good cleaning action to skin, while also having clearing and activating the channels and collaterals
Effect, so being to have certain therapeutic effect for scar caused by pernio.
Phoenix tree leaf, phoenix tree leaf have good anastalsis, usually can be used for the treatment of mankind's knife wound bleeding, and when treatment can
It the later phoenix tree leaf of drying is smashed, is then directly applied on injured position, can stop blooding quickly, add in this side
Enter a certain amount of phoenix tree leaf, is to be able to cure the bleeding that is open caused by pernio.
Carrot leaf, containing vitamin and mineral, vitamin A and B1 are very high, and contained vitamin C is also very abundant, and contains
There is abundant moisture, there is moisturizing beauty treatment, carrot leaf extracting solution is added in this side has reparation to the skin of frostbite
Effect.
Caulis Spatholobi, bitter without dry, temperature is without strong, and promoting circulation of blood dissipates the stasis of blood, and relaxing tendons and activating collaterals, to treat, passages through which vital energy circulates is unsmooth, channels discord is sick
The common medicine of disease, and pernio patient's Duo Yin venous congestions, local blood circulation is bad and falls ill, and Caulis Spatholobi is added in this side,
The blood circulation that can promote pernio affected part promotes the reparation as early as possible of skin at pernio.
Dried orange peel contains multivitamin and organic acid, can be used to nourish and moisturize skin, and has apparent crease-resistant effect, and old
Leatherware plays the role of antiallergy, anti-inflammatory, hemostasis, and dried orange peel, which is added, in this side can not only prevent pernio patient because smearing ointment skin
The phenomenon that sensitive and allergy, meanwhile, for the pernio affected part that brutal fracture is bled have the function of it is anti-inflammatory, stop blooding, furthermore, because
The multivitamin and organic acid that dried orange peel is rich in, can also promote the skin repair in pernio affected part.
Lotus seeds, it is sweet in flavor, puckery, it is mild-natured, have effects that keep skin whitening ruddy, the lotus seeds pulverized are added in this side,
The skin for becoming obscure because of pernio can be repaired, affected part skin is made to restore as before.
Sesame flower, flat property and sweet taste have detumescence effect, and it is repeatedly red to treat the local skin caused by pernio in this side
Spot, tumidus damage.
Cactus, cactus is cold in nature, bitter, containing ingredients such as triterpene, malic acid, succinic acid, potassium carbonate, there is promoting the circulation of qi to live
The effect of blood, removing toxicity for detumescence, can treat the local skin arteries caused by pernio in this side and benumb and expand, and vein becomes silted up
Blood, the undesirable symptom of local blood circulation, and also have the function of detumescence to the skin of affected part swelling.
Glycerin monostearate contains C16- C18Long chain fatty acids carry out esterification with glycerine and are made, and are a kind of
The surfactant of nonionic, it is existing hydrophilic and has lipophilic group, has the multiple functions such as wetting, emulsification, blistering, herein
It is used as emulsifier in side, keeps lotion fine and smooth, it is lubricious.
Vaseline, smearing can keep skin wet on the skin, and the skin histology of wound location is made to keep optimum state,
The bacterium in air and skin contact are blocked, to reduce the possibility of infection, accelerates the reparation of skin itself
Ability.
The invention discloses a kind of methods prepared for treating medical ointment for treating chilblain, including following preparation process：
1) wormwood, Caulis Spatholobi and the dried orange peel after drying are weighed, and three is ground crushing, falls mixture after crushing
Enter in three-necked flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filter
Extracting solution A is made in liquid；
2) lotus seeds after drying are weighed and are pulverized, 200 mesh screens are crossed, it is spare；
3) fresh phoenix tree leaf and carrot leaf are put into together in pot and carry out heating boiling with 1000ml tap water, 30 minutes
Afterwards, it pulls residual leaf out, heating concentration then is carried out to mixed liquor, after being evaporated solvent, obtain aqueous extract；
4) it after cleaning the sesame flower newly won and cactus, is put into together in mortar and carries out smashing grinding to pieces, be used in combination anhydrous
Alcohol solvent carries out immersion 2~3 hours to milled mixtures, and filtrate is collected in filtering；Obtain alcohol extract；By the alcohol extracting
Liquid is added in aqueous extract and is mixed, and obtains mixed extract B；
5) extracting solution A and mixed extract B are mixed, after evaporating solvent, obtains extraction medicament C；Then it will pulverize
Lotus seeds pour into extraction medicament C, be uniformly mixing to obtain medicament D；
6) glycerin monostearate and vaseline are poured into beaker and is mixed, medicament D is then poured into the beaker
In stir together, obtain white paste；
7) it will be carried out in the white paste injection high pressure homogenizer high-pressure homogeneous to get to target ointment.
Further, in order to which the ingredient for extracting wormwood, Caulis Spatholobi and dried orange peel is more thorough, with absolute ethyl alcohol pair in step 1)
The temperature that mixture is heated at reflux is controlled at 80~85 DEG C, is not less than 50 DEG C to the temperature that phegma is filtered while hot.
Further, the presence of solvent absolute alcohol influences drug effect and is stimulated after avoiding manufactured ointment from smearing in order to prevent
Skin carries out heating steaming with vacuum rotary evaporator after mixing extracting solution A and mixed extract B in step 5) to mixed liquor
Solvent is sent out, and mixed liquor is carried out before evaporating solvent removing water process.
Further, solvent absolute ethyl alcohol is mixed soluble in water in order to prevent, is miscible in mixed liquor and is removed insufficient, needs elder generation
Mixed liquor is carried out to remove water process, meanwhile, in order to preferably remove the moisture in mixed liquor, while mixed liquor is not interfered with again
Degree of purity, except water process is that A3 types molecular sieve or addition anhydrous calcium chloride particle are added in mixed liquor.
Further, finer and smoother in order to make sesame flower and cactus be ground, active ingredient can be fully extracted,
Sesame flower and cactus are smashed to pieces in process of lapping in step 4), 5~8g quartz sands can be added in the mortar as grinding
Agent.
The invention discloses a kind of ointment and preparation method thereof for treating pernio, made from preparation method of the present invention
The ointment for the treatment of pernio has the advantages that：This side has extraordinary natural antibacterial effect, has to skin clear well
Clean effect, while also having the function of clearing and activating the channels and collaterals, the pernio caused by local blood circulation is bad can be cured；Contain in this side
Stop blooding, the ingredient of removing toxicity for detumescence, the symptom of be open caused by pernio bleeding and redness can be cured；Again because containing dimension in the party
Raw element, minerals and organic acid have the function of repairing to the skin of frostbite.The skin for becoming obscure because of pernio can be repaired,
Affected part skin is set to restore as before；And the lotion is fine and smooth, lubricious, non-greasy, can be used as daily hand lotion and uses, while can also play
Prevent frostbitten effect.
Specific implementation mode
It elaborates below to the embodiment of the present invention, the present embodiment is carried out lower based on the technical solution of the present invention
Implement, gives detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following implementation
Example.
Embodiment 1
Embodiment 1 discloses a kind of ointment for treating pernio, including following raw material components：Wormwood, phoenix tree leaf, Hu Luo
Bu Ye, Caulis Spatholobi, dried orange peel, lotus seeds, sesame flower, cactus, glycerin monostearate and vaseline.
Wherein, the parts by weight of raw material components are preferably：
A method of being used to prepare the above treatment medical ointment for treating chilblain, including following preparation process：
1) wormwood, Caulis Spatholobi and the dried orange peel after drying are weighed, and three is ground crushing, falls mixture after crushing
Enter in three-necked flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filter
Extracting solution A is made in liquid；The temperature being heated at reflux to mixture with absolute ethyl alcohol is controlled at 80 DEG C, while hot to phegma into
The temperature of row filtering is not less than 50 DEG C；
2) lotus seeds after drying are weighed and are pulverized, 200 mesh screens are crossed, it is spare；
3) fresh phoenix tree leaf and carrot leaf are put into together in pot and carry out heating boiling with 1000ml tap water, 30 minutes
Afterwards, it pulls residual leaf out, heating concentration then is carried out to mixed liquor, after being evaporated solvent, obtain aqueous extract；
4) it after cleaning the sesame flower newly won and cactus, is put into together in mortar and carries out smashing grinding to pieces, to sesame flower
It is smashed to pieces in process of lapping with cactus, 5g quartz sands can be added in mortar as grinding agent, be used in combination anhydrous ethanol solvent to grinding
Mill mixture impregnate 2 hours, and filtrate is collected in filtering；Obtain alcohol extract；By alcohol extract be added in aqueous extract into
Row is mixed, and obtains mixed extract B；
5) extracting solution A and mixed extract B are mixed, after evaporating solvent, obtains extraction medicament C；Then it will pulverize
Lotus seeds pour into the extraction medicament C, be uniformly mixing to obtain medicament D；After extracting solution A and mixed extract B is mixed, vacuum is used
Rotary Evaporators carry out heating evaporation solvent to mixed liquor, and to carry out before evaporating solvent removing water process to mixed liquor.
Wherein, except water process is that A3 types molecular sieve or addition anhydrous calcium chloride particle are added in mixed liquor；
6) glycerin monostearate and vaseline are poured into beaker and is mixed, then pour into medicament D one in beaker
With stirring, white paste is obtained；
7) white paste is injected in high pressure homogenizer carry out it is high-pressure homogeneous to get to target ointment.
Embodiment 2
Embodiment 2 discloses a kind of ointment for treating pernio, including following raw material components：Wormwood, phoenix tree leaf, Hu Luo
Bu Ye, Caulis Spatholobi, dried orange peel, lotus seeds, sesame flower, cactus, glycerin monostearate and vaseline.
Wherein, the parts by weight of raw material components are：
A method of being used to prepare the above treatment medical ointment for treating chilblain, including following preparation process：
1) wormwood, Caulis Spatholobi and the dried orange peel after drying are weighed, and three is ground crushing, falls mixture after crushing
Enter in three-necked flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filter
Extracting solution A is made in liquid；The temperature being heated at reflux to mixture with absolute ethyl alcohol is controlled at 81 DEG C, while hot to phegma into
The temperature of row filtering is not less than 50 DEG C；
2) lotus seeds after drying are weighed and are pulverized, 200 mesh screens are crossed, it is spare；
3) fresh phoenix tree leaf and carrot leaf are put into together in pot and carry out heating boiling with 1000ml tap water, 30 minutes
Afterwards, it pulls residual leaf out, heating concentration then is carried out to mixed liquor, after being evaporated solvent, obtain aqueous extract；
4) it after cleaning the sesame flower newly won and cactus, is put into together in mortar and carries out smashing grinding to pieces, to sesame flower
It is smashed to pieces in process of lapping with cactus, 6g quartz sands can be added in mortar as grinding agent, be used in combination anhydrous ethanol solvent to grinding
Mill mixture impregnate 2 hours, and filtrate is collected in filtering；Obtain alcohol extract；By alcohol extract be added in aqueous extract into
Row is mixed, and obtains mixed extract B；
5) extracting solution A and mixed extract B are mixed, after evaporating solvent, obtains extraction medicament C；Then it will pulverize
Lotus seeds pour into the extraction medicament C, be uniformly mixing to obtain medicament D；After extracting solution A and mixed extract B is mixed, vacuum is used
Rotary Evaporators carry out heating evaporation solvent to mixed liquor, and to carry out before evaporating solvent removing water process to mixed liquor.
Wherein, except water process is that A3 types molecular sieve or addition anhydrous calcium chloride particle are added in mixed liquor；
6) glycerin monostearate and vaseline are poured into beaker and is mixed, then pour into medicament D one in beaker
With stirring, white paste is obtained；
7) white paste is injected in high pressure homogenizer carry out it is high-pressure homogeneous to get to target ointment.
Embodiment 3
Embodiment 3 discloses a kind of ointment for treating pernio, including following raw material components：Wormwood, phoenix tree leaf, Hu Luo
Bu Ye, Caulis Spatholobi, dried orange peel, lotus seeds, sesame flower, cactus, glycerin monostearate and vaseline.
Wherein, the parts by weight of raw material components are：
A method of being used to prepare the above treatment medical ointment for treating chilblain, including following preparation process：
1) wormwood, Caulis Spatholobi and the dried orange peel after drying are weighed, and three is ground crushing, falls mixture after crushing
Enter in three-necked flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filter
Extracting solution A is made in liquid；The temperature being heated at reflux to mixture with absolute ethyl alcohol is controlled at 85 DEG C, while hot to phegma into
The temperature of row filtering is not less than 50 DEG C；
2) lotus seeds after drying are weighed and are pulverized, 200 mesh screens are crossed, it is spare；
3) fresh phoenix tree leaf and carrot leaf are put into together in pot and carry out heating boiling with 1000ml tap water, 30 minutes
Afterwards, it pulls residual leaf out, heating concentration then is carried out to mixed liquor, after being evaporated solvent, obtain aqueous extract；
4) it after cleaning the sesame flower newly won and cactus, is put into together in mortar and carries out smashing grinding to pieces, to sesame flower
It is smashed to pieces in process of lapping with cactus, 8g quartz sands can be added in mortar as grinding agent, be used in combination anhydrous ethanol solvent to grinding
Mill mixture impregnate 3 hours, and filtrate is collected in filtering；Obtain alcohol extract；By alcohol extract be added in aqueous extract into
Row is mixed, and obtains mixed extract B；
5) extracting solution A and mixed extract B are mixed, after evaporating solvent, obtains extraction medicament C；Then it will pulverize
Lotus seeds pour into the extraction medicament C, be uniformly mixing to obtain medicament D；After extracting solution A and mixed extract B is mixed, vacuum is used
Rotary Evaporators carry out heating evaporation solvent to mixed liquor, and to carry out before evaporating solvent removing water process to mixed liquor.
Wherein, except water process is that A3 types molecular sieve or addition anhydrous calcium chloride particle are added in mixed liquor；
6) glycerin monostearate and vaseline are poured into beaker and is mixed, then pour into medicament D one in beaker
With stirring, white paste is obtained；
7) white paste is injected in high pressure homogenizer carry out it is high-pressure homogeneous to get to target ointment.
Embodiment 4
Embodiment 4 discloses a kind of ointment for treating pernio, including following raw material components：Wormwood, phoenix tree leaf, Hu Luo
Bu Ye, Caulis Spatholobi, dried orange peel, lotus seeds, sesame flower, cactus, glycerin monostearate and vaseline.
Wherein, the parts by weight of raw material components are：
A method of being used to prepare the above treatment medical ointment for treating chilblain, including following preparation process：
1) wormwood, Caulis Spatholobi and the dried orange peel after drying are weighed, and three is ground crushing, falls mixture after crushing
Enter in three-necked flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filter
Extracting solution A is made in liquid；The temperature being heated at reflux to mixture with absolute ethyl alcohol is controlled at 83 DEG C, while hot to phegma into
The temperature of row filtering is not less than 50 DEG C；
2) lotus seeds after drying are weighed and are pulverized, 200 mesh screens are crossed, it is spare；
3) fresh phoenix tree leaf and carrot leaf are put into together in pot and carry out heating boiling with 1000ml tap water, 30 minutes
Afterwards, it pulls residual leaf out, heating concentration then is carried out to mixed liquor, after being evaporated solvent, obtain aqueous extract；
4) it after cleaning the sesame flower newly won and cactus, is put into together in mortar and carries out smashing grinding to pieces, to sesame flower
It is smashed to pieces in process of lapping with cactus, 7g quartz sands can be added in mortar as grinding agent, be used in combination anhydrous ethanol solvent to grinding
Mill mixture impregnate 2.5 hours, and filtrate is collected in filtering；Obtain alcohol extract；Alcohol extract is added in aqueous extract
It is mixed, obtains mixed extract B；
5) extracting solution A and mixed extract B are mixed, after evaporating solvent, obtains extraction medicament C；Then it will pulverize
Lotus seeds pour into the extraction medicament C, be uniformly mixing to obtain medicament D；After extracting solution A and mixed extract B is mixed, vacuum is used
Rotary Evaporators carry out heating evaporation solvent to mixed liquor, and to carry out before evaporating solvent removing water process to mixed liquor.
Wherein, except water process is that A3 types molecular sieve or addition anhydrous calcium chloride particle are added in mixed liquor；
6) glycerin monostearate and vaseline are poured into beaker and is mixed, then pour into medicament D one in beaker
With stirring, white paste is obtained；
7) white paste is injected in high pressure homogenizer carry out it is high-pressure homogeneous to get to target ointment.
One, for the clinical test of pernio patient.
1, subjects：250 pernio patients, man 165, female 85.
2, therapy
250 pernio patients are divided by treatment group's (totally four groups of Examples 1 to 4) and control group using the principle of parallel control
(totally one group), every group of 50 patients.
Through statistical analysis, each group Gender, age, the course of disease, the there was no significant difference (P such as grading>0.05), have
There is comparativity.
Treatment group：After being dried within 5 minutes with warm water's immersion affected part, medical ointment for treating chilblain produced by the present invention is smeared in affected part, often
Day 2 times, once in the morning and once at night.
Control group：Painting ice king's crocodile oil pernio disappears emulsifiable paste, application method and the same treatment group of the frequency.
3, criterion：
(1) effective：Pernio affected part symptom disappears, and skin heals completely, no scar；
(2) effectively：Cardinal symptom disappears, and the skin frostbite surface of a wound heals substantially, there is slight trace；
(3) invalid：Frostbite surface of a wound symptom is not improved.
Data after contrast test are recorded, the affected part number of days used that fully recovers is fewer, rehabilitation people in same time
Number more at most drug effect is better.
4, result on trial：It is shown in Table 1.
Table 1
The data that are recorded by table 1 are it is found that behind the medical ointment for treating chilblain coating affected part that the present invention is prepared, substantially in two weeks,
The illness of patient all disappears, and skin heals completely at pernio, and the ointment slowly effect in control group, and when application being needed to cure
Between it is longer, and found in later stage long-term observation, the same affected part of some patients is also reoccurred the illness of pernio.
Two, typical case：
Lin, women, 37 years old, county government functionary was often away on official business, and hand and auricle edge suffer from always pernio, freeze
Do not crack redness for injury, and only by lump sense is pressed with, itch is often understood in warm interior, but is in the coming year also president getting chilblains
Pernio smears kibe ointment produced by the present invention after two weeks, that is, fully recovers, and is not recurred again in the latter year.
Bian, women 42 years old, are engaged in agriculture, because of long-term work, winter does not take maintenance to hand yet, often descends cold water
It does the wash so that frostbite of hand recurs throughout the year, and entire the back of the hand is red and swollen, and is frequently accompanied by breach bleeding, smears the present invention and is made
Kibe ointment after two weeks, pernio wound heals substantially, and hand skin is repaired substantially after one month, and in latter year not again
Recurrence.
It is desolate certain, man, 39 years old, construction site worker, because working in the work of building site, in the case of morning in winter temperature is lower just
Start outdoor work, the masonry of hand contact raw food so that hand frostbite is more serious, and redness has breach, smears the present invention
After two weeks, pernio wound heals kibe ointment obtained substantially, and hand skin is repaired substantially after one month, and in latter year simultaneously
It does not recur again.
Chen, female, 32 years old, housewife because constitution is partially cold, and managed household affairs for a long time, in winter often in contact with cold water,
Make hand frostbite, but because daily nursing is proper, pernio is slighter, smears kibe ointment produced by the present invention after a week, hand skin
Restore to the original state.
The medical ointment for treating chilblain is well-established by neighbouring group at present, and in the winter especially in the pernio high-incidence season, the ointment is
Through being considered as standing medicine in family, in winter, no pernio history, it can be used as hand lotion, can moisturize the skin and play
The effect of anti-frostbite；After having patient's use of pernio history, pernio can be made to effect a radical cure, no longer recurred, skin is made to restore as before.At present
This drug carries out cooperation by production, study and research with certain institute, and each medicine in this pharmaceutical formulation is specifically probed by the resources for research of colleges and universities
The effect of object and make a concrete analysis of its pharmacology.
Claims (8)
1. a kind of ointment for treating pernio, which is characterized in that including following raw material components：Wormwood, phoenix tree leaf, carrot leaf,
Caulis Spatholobi, dried orange peel, lotus seeds, sesame flower, cactus, glycerin monostearate and vaseline.
2. the ointment as described in claim 1 for treating pernio, which is characterized in that the parts by weight of the raw material components
For：
3. the ointment as claimed in claim 2 for treating pernio, which is characterized in that the parts by weight of the raw material components
For：
4. a kind of as described in any one of claims 1-3 for treating the preparation method of medical ointment for treating chilblain, which is characterized in that including with
Lower preparation process：
1) wormwood, Caulis Spatholobi and the dried orange peel after drying are weighed, and three is ground crushing, three are poured the mixture into after crushing
In mouth flask, absolute ethyl alcohol is used in combination to be heated at reflux mixture；Then phegma is filtered while hot, retains filtrate,
Extracting solution A is made；
2) lotus seeds after drying are weighed and are pulverized, 200 mesh screens are crossed, it is spare；
3) fresh phoenix tree leaf and carrot leaf are put into together in pot and carry out heating boiling with 1000ml tap water, after 30 minutes, fishing
Go out residual leaf, heating concentration then is carried out to mixed liquor, after being evaporated solvent, obtains aqueous extract；
4) it after cleaning the sesame flower newly won and cactus, is put into together in mortar and carries out smashing grinding to pieces, absolute ethyl alcohol is used in combination
Solvent carries out immersion 2~3 hours to milled mixtures, and filtrate is collected in filtering；Obtain alcohol extract；The alcohol extract is added
Enter into the aqueous extract and be mixed, obtains mixed extract B；
5) the extracting solution A and mixed extract B are mixed, after evaporating solvent, obtains extraction medicament C；Then it will pulverize
Lotus seeds pour into the extraction medicament C, be uniformly mixing to obtain medicament D；
6) glycerin monostearate and vaseline are poured into beaker and is mixed, then pour into medicament D one in the beaker
With stirring, white paste is obtained；
7) it will be carried out in the white paste injection high pressure homogenizer high-pressure homogeneous to get to target ointment.
5. the preparation method as claimed in claim 4 for treating medical ointment for treating chilblain, which is characterized in that with anhydrous second in step 1)
The temperature that alcohol is heated at reflux mixture is controlled at 80~85 DEG C, is not less than 50 to the temperature that phegma is filtered while hot
℃。
6. the preparation method as claimed in claim 4 for treating medical ointment for treating chilblain, which is characterized in that carried described in step 5)
After taking liquid A and mixed extract B mixing, heating evaporation solvent is carried out to mixed liquor with vacuum rotary evaporator, and evaporating
Mixed liquor is carried out removing water process before solvent.
7. the preparation method for treating medical ointment for treating chilblain as claimed in claim 6, which is characterized in that it is described except water process be
A3 types molecular sieve is added in mixed liquor or anhydrous calcium chloride particle is added.
8. the preparation method as claimed in claim 4 for treating medical ointment for treating chilblain, which is characterized in that the sesame in step 4)
Fried dough twist and cactus are smashed to pieces in process of lapping, and 5~8g quartz sands can be added in the mortar as grinding agent.
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| CN108355042A (en) * | 2018-05-28 | 2018-08-03 | 陈雨薇 | A kind of anti-inflammatory analgetic ointment and preparation method thereof |
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| CN106540228A (en) * | 2016-11-06 | 2017-03-29 | 高金水 | A kind of Chinese medicinal formulae for treating chilblain |
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| CN106540228A (en) * | 2016-11-06 | 2017-03-29 | 高金水 | A kind of Chinese medicinal formulae for treating chilblain |
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Application publication date: 20180810 |