CN107811904B - Anti-inflammatory freckle-removing vanishing cream and preparation method thereof - Google Patents
Anti-inflammatory freckle-removing vanishing cream and preparation method thereof Download PDFInfo
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- CN107811904B CN107811904B CN201711023963.3A CN201711023963A CN107811904B CN 107811904 B CN107811904 B CN 107811904B CN 201711023963 A CN201711023963 A CN 201711023963A CN 107811904 B CN107811904 B CN 107811904B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
Abstract
The invention discloses an anti-inflammatory freckle-removing vanishing cream and a preparation method thereof, and the freckle-removing wrinkle-resisting vanishing cream containing a cannabis sativa leaf extract comprises the following components in parts by weight: 5-8 parts of white oil, 7-12 parts of white vaseline, 7-13 parts of glyceryl monostearate, 1-9 parts of hemp seed oil, 15-25 parts of lanolin, 3-8 parts of a special hemp leaf extract rich in bisabolol and cannabidiol, 0-0.2 part of vitamin E, 0.2-0.3 part of triethanolamine, 0.2-0.3 part of essence, 0.03-0.05 part of preservative and 30-60 parts of deionized water. The anti-inflammatory freckle-removing vanishing cream is added with the special cannabis sativa leaf extract rich in bisabolol and cannabidiol, the extract has obvious anti-inflammatory and freckle removing effects, and the like, wherein the rich bisabolol is reserved to synergistically enhance the anti-inflammatory and freckle removing effects of the cannabidiol, and the cannabis sativa leaf extract can be maintained to play stronger anti-inflammatory and freckle removing effects in a longer time.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-inflammatory freckle-removing vanishing cream and a preparation method thereof.
Background
In the United states and Europe in recent two years, a new cosmetic series, the extract type cosmetics of hemp leaf rise rapidly, and the market for the popular functional cosmetics begins. The cosmetic prepared from the extract of industrial hemp leaf is considered to have the effects of treating fungal or bacterial infection of skin, relieving pain, anti-inflammatory, preventing speckle, anti-aging and anti-wrinkle. In 2016, cosmetics of extract class of industrial hemp leaves of MGC Pharma company were approved by european cosmetics committee and have been marketed in all europe.
We found in related experiments that the general cannabis sativa leaf extract is traditionally known as Cannabidiol (canabidiol) as the major active ingredient in cosmetic applications, but is not known by many, or inadvertently missing the anti-inflammatory and anti-irritant active ingredient in another cannabis sativa leaf, bisabolol (Alpha-bsabolol); the natural bisabolol used previously is mainly from chamomile flowers. It can be used for protecting and caring allergic skin, and has good antibacterial and antiinflammatory effects. In addition, the bisabolol has the characteristic of improving the penetrability of other active ingredients, and can help the active ingredients such as cannabidiol to be better absorbed through skin when the addition amount of the active ingredients is relatively small, so that the absorption rate is improved, and the medicinal activity is exerted. Bisabolol also has good skin compatibility. The bisabolol has good stability, and can help prolong the shelf life of cosmetics.
For the reasons, the modern phytochemical technology is adopted to extract the special cannabis sativa leaf extract rich in bisabolol and cannabidiol from industrial cannabis sativa, toxic component tetrahydrocannabinol is reduced to be below international regulatory standard, and two main active ingredients of bisabolol and cannabidiol are selectively reserved and enriched in the special cannabis sativa leaf extract rich in bisabolol and cannabidiol. According to different requirements, the bisabolol content of the extract of the cannabis sativa leaves special for enriching the bisabolol and the cannabidiol is 0.1 to 15 percent, and the cannabidiol content is 10 to 80 percent.
Disclosure of Invention
The invention aims to provide an anti-inflammatory freckle-removing vanishing cream and a preparation method thereof, and solves the problems that many freckle-removing products do not have anti-inflammatory and anti-allergic performances for allergic skin and can easily cause more serious skin problems after long-term use.
In order to solve the technical problems, the invention adopts the following technical scheme:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 5-8 parts of white oil, 7-12 parts of white vaseline, 7-13 parts of glyceryl monostearate, 1-9 parts of hemp seed oil, 15-25 parts of lanolin, 3-8 parts of a special hemp leaf extract rich in bisabolol and cannabidiol, 0-0.2 part of vitamin E, 0.2-0.3 part of triethanolamine, 0.2-0.3 part of essence, 0.03-0.05 part of preservative and 30-60 parts of deionized water.
Preferably, the anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 6-8 parts of white oil, 7-10 parts of white vaseline, 7-10 parts of glyceryl monostearate, 1-4 parts of hemp seed oil, 15-20 parts of lanolin, 5-8 parts of a special cannabis sativa leaf extract rich in bisabolol and cannabidiol, 0.1 part of vitamin E, 0.3 part of triethanolamine, 0.3 part of essence, 0.05 part of preservative and 40-60 parts of deionized water.
Preferably, the anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 7-8 parts of white oil, 8-9 parts of white vaseline, 9-10 parts of glyceryl monostearate, 3-4 parts of hemp seed oil, 20-25 parts of lanolin, 5-6 parts of a special hemp leaf extract rich in bisabolol and cannabidiol, 0.1 part of vitamin E, 0.3 part of triethanolamine, 0.3 part of essence, 0.05 part of preservative and 40-47 parts of deionized water.
Preferably, the extraction method of the special cannabis sativa leaf extract enriched in bisabolol and cannabidiol comprises the following steps:
a1: selecting industrial hemp leaves, drying at 105 ℃, crushing, extracting by using a supercritical carbon dioxide extractor, filtering, roughly separating, and concentrating to obtain an extract A;
a2: separating the extract A with normal phase chromatography filler and reverse phase chromatography filler to obtain effective components bisabolol and cannabidiol;
a3: the bisabolol is enriched to the content of 0.1-15 percent and the cannabidiol content of 10-80 percent, and the special cannabis sativa leaf extract enriched with the bisabolol and the cannabidiol is obtained.
The preparation method of the anti-inflammatory freckle-removing vanishing cream comprises the following steps:
s0: white oil, white vaseline, glyceryl monostearate, hemp seed oil, lanolin, special cannabis sativa leaf extract rich in bisabolol and cannabidiol, and vitamin E are used as component A, triethanolamine and deionized water are used as component B, and essence and antiseptic are used as component C;
s1: heating the component A to 60-80 ℃ and keeping the temperature constant;
s2: heating the component B to 60-80 ℃ and keeping the temperature constant;
s3: slowly adding the component A into the component B under the condition of continuous stirring, and fully mixing and emulsifying the two components;
s4: under the condition of continuous stirring, when the temperature is reduced to 35-55 ℃, adding the component C, and continuously stirring to fully mix and emulsify all the components;
s5: cooling to room temperature, and bottling.
Preferably, the component A comprises, by weight, 5-8 parts of white oil, 7-12 parts of white vaseline, 7-13 parts of glyceryl monostearate, 1-9 parts of hemp seed oil, 15-25 parts of lanolin, 3-8 parts of a special hemp leaf extract rich in bisabolol and cannabidiol, and 0-0.2 part of vitamin E.
Preferably, the component B comprises 0.2-0.3 part of triethanolamine and 30-60 parts of deionized water in parts by weight.
Preferably, the component C comprises 0.2-0.3 part of essence and 0.03-0.05 part of preservative by weight part.
Compared with the prior art, the invention has the beneficial effects that:
the anti-inflammatory freckle-removing vanishing cream is added with the special cannabis sativa leaf extract rich in bisabolol and cannabidiol, the extract has obvious anti-inflammatory and freckle removing effects, and the like, wherein the rich bisabolol is reserved to synergistically enhance the anti-inflammatory and freckle removing effects of the cannabidiol, so that the cannabis sativa leaf extract can be maintained to play stronger anti-inflammatory and freckle removing effects for a long time; and the added vitamin E synergistically enhances the anti-aging and anti-wrinkle effects.
The raw materials in the invention are simple, are selected from natural plant extracts, and have no side effect; meanwhile, the invention has simple manufacturing process and is easy to produce and process.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 5g of white oil, 7g of white vaseline, 7g of glyceryl monostearate, 1g of hemp seed oil, 15g of lanolin, 3g of a special cannabis leaf extract rich in bisabolol and cannabidiol, 0.2g of triethanolamine, 0.2g of essence, 0.03g of preservative and 30g of deionized water.
Example 2:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 8g of white oil, 12g of white vaseline, 13g of glyceryl monostearate, 9g of hemp seed oil, 25g of lanolin, 8g of a special hemp leaf extract rich in bisabolol and cannabidiol, 0.2g of vitamin E, 0.3g of triethanolamine, 0.3g of essence, 0.05g of preservative and 60g of deionized water.
Example 3:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 6g of white oil, 10g of white vaseline, 10g of glyceryl monostearate, 7g of hemp seed oil, 20g of lanolin, 5g of a special cannabis sativa leaf extract rich in bisabolol and cannabidiol, 0.1g of vitamin E, 0.2g of triethanolamine, 0.2g of essence, 0.04g of preservative and 50g of deionized water.
Example 4:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 6g of white oil, 7g of white vaseline, 7g of glycerin monostearate, 1g of hemp seed oil, 15g of lanolin, 5g of a special cannabis sativa leaf extract rich in bisabolol and cannabidiol, 0.1g of vitamin E, 0.3g of triethanolamine, 0.3g of essence, 0.05g of preservative and 40g of deionized water.
Example 5:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 8g of white oil, 10g of white vaseline, 10g of glyceryl monostearate, 4g of hemp seed oil, 20g of lanolin, 8g of a special hemp leaf extract rich in bisabolol and cannabidiol, 0.1g of vitamin E, 0.3g of triethanolamine, 0.3g of essence, 0.05g of preservative and 60g of deionized water.
Example 6:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 7g of white oil, 9g of white vaseline, 9g of glycerin monostearate, 3g of hemp seed oil, 18g of lanolin, 6g of a special cannabis sativa leaf extract rich in bisabolol and cannabidiol, 0.1g of vitamin E, 0.3g of triethanolamine, 0.3g of essence, 0.05g of preservative and 50g of deionized water.
Example 7:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 7g of white oil, 8g of white vaseline, 9g of glycerin monostearate, 3g of hemp seed oil, 20g of lanolin, 5g of a special cannabis sativa leaf extract rich in bisabolol and cannabidiol, 0.1g of vitamin E, 0.3g of triethanolamine, 0.3g of essence, 0.05g of preservative and 40g of deionized water.
Example 8:
an anti-inflammatory freckle-removing vanishing cream comprises the following components in parts by weight: 8g of white oil, 9g of white vaseline, 10g of glyceryl monostearate, 4g of hemp seed oil, 25g of lanolin, 6g of a special cannabis sativa leaf extract rich in bisabolol and cannabidiol, 0.1g of vitamin E, 0.3g of triethanolamine, 0.3g of essence, 0.05g of preservative and 47g of deionized water.
The method for extracting the special cannabis sativa leaf extract rich in bisabolol and cannabidiol in any one of embodiments 1-8 comprises the following steps:
a1: selecting No. 7 Yunnan industrial hemp leaves, drying at 105 ℃, crushing, extracting by using a supercritical carbon dioxide extraction instrument, filtering, roughly separating, and concentrating to obtain an extract A;
a2: separating the extract A with normal phase chromatography filler and reverse phase chromatography filler to obtain effective components bisabolol and cannabidiol; removing toxic and useless components such as tetrahydrocannabinol;
a3: the bisabolol is enriched to the content of 0.1-15 percent and the cannabidiol content of 10-80 percent, and the special cannabis sativa leaf extract enriched with the bisabolol and the cannabidiol is obtained.
The essential components of the specific cannabis sativa leaf extract enriched in bisabolol and cannabidiol in examples 1-8 are bisabolol and cannabidiol; the general cannabidiol serving as the main component of the cannabis sativa leaf extract can be used for protecting and nursing allergic skin and has good sterilizing and anti-inflammatory effects; the bisabolol has the characteristic of improving the penetrability of other active ingredients, and can help the active ingredients such as cannabidiol to be better absorbed through skin when the addition amount of the active ingredients is relatively small, so that the absorption rate is improved, and the medicinal activity is exerted.
The preparation method of the anti-inflammatory freckle-removing vanishing cream in any embodiment of embodiments 1 to 8 comprises the following steps:
s0: white oil, white vaseline, glyceryl monostearate, hemp seed oil, lanolin, special cannabis sativa leaf extract rich in bisabolol and cannabidiol, and vitamin E are used as component A, triethanolamine and deionized water are used as component B, and essence and antiseptic are used as component C;
s1: heating the component A to 60-80 ℃ and keeping the temperature constant;
s2: heating the component B to 60-80 ℃ and keeping the temperature constant;
s3: slowly adding the component A into the component B under the condition of continuous stirring, and fully mixing and emulsifying the two components;
s4: under the condition of continuous stirring, when the temperature is reduced to 35-55 ℃, adding the component C, and continuously stirring to fully mix and emulsify all the components;
s5: cooling to room temperature, and bottling.
The anti-inflammatory freckle-removing vanishing cream is added with the special cannabis sativa leaf extract rich in bisabolol and cannabidiol, the extract has obvious anti-inflammatory and freckle removing effects, and the like, wherein the rich bisabolol is reserved to synergistically enhance the anti-inflammatory and freckle removing effects of the cannabidiol, so that the cannabis sativa leaf extract can be maintained to play stronger anti-inflammatory and freckle removing effects for a long time; and the added vitamin E synergistically enhances the anti-aging and anti-wrinkle effects.
The anti-inflammatory freckle-removing vanishing cream is prepared by dividing raw materials into three groups, wherein the group A is oil-soluble, the group B is water-soluble, and the group C is afraid of heat, so that the raw materials with the same property are mixed to facilitate the preparation of the product, and the efficacy of the final product is exerted to the maximum. The temperature of 60-80 ℃ is a temperature which is easy to emulsify, and is more suitable for mixing and emulsifying each component; because essence can not bear higher temperature, consequently set the temperature for 35 ~ 55 ℃, prevent that essence from being destroyed.
Experimental example: randomly selecting 90 persons and dividing into 9 groups for product experiments, wherein the 1 st group to the 8 th group use the products prepared in the embodiments 1 to 8 respectively, and the 9 th group use the common freckle removing products on the market, and the experimental data are shown in table 1.
TABLE 1
As can be seen from the comparison between the table 1 and the examples, the freckle removing effect of each example of the invention is obviously superior to that of a common freckle removing product; in addition, vitamin E is not added in the embodiment 1, and the vitamin E is added in the embodiments 2-8, so that the freckle removing effect of the added vitamin E is obviously better than that of the vitamin E which is not added.
Among the 90 subjects, 23 of the 1 st to 8 th groups were sensitive skin, and 3 of the 9 th group were sensitive skin; experiments show that the 23 sensitive skins in the groups 1 to 8 have no skin allergy problem when the products of the embodiments 1 to 8 are used, and also have certain anti-inflammatory effect, and can quickly eliminate skin inflammation; whereas 3 sensitive skin experimenters in group 9 all developed allergic problems. Therefore, the anti-inflammatory and freckle-removing product is safe and effective, can effectively resist various types of skin, and has obvious anti-inflammatory and freckle-removing effects.
Although the invention has been described herein with reference to a number of illustrative embodiments thereof, it should be understood that numerous other modifications and embodiments can be devised by those skilled in the art that will fall within the spirit and scope of the principles of this disclosure. More specifically, various variations and modifications are possible in the component parts and/or arrangements of the subject combination arrangement within the scope of the disclosure and claims of this application. In addition to variations and modifications in the component parts and/or arrangements, other uses will also be apparent to those skilled in the art.
Claims (7)
1. An anti-inflammatory freckle-removing vanishing cream is characterized in that: the paint comprises the following components in parts by weight: 5-8 parts of white oil, 7-12 parts of white vaseline, 7-13 parts of glyceryl monostearate, 1-9 parts of hemp seed oil, 15-25 parts of lanolin, 3-8 parts of a special hemp leaf extract rich in bisabolol and cannabidiol, 0-0.2 part of vitamin E, 0.2-0.3 part of triethanolamine, 0.2-0.3 part of essence, 0.03-0.05 part of preservative and 30-60 parts of deionized water;
the extraction method of the special cannabis sativa leaf extract rich in bisabolol and cannabidiol comprises the following steps:
a1: selecting industrial hemp leaves, drying at 105 ℃, crushing, extracting by using a supercritical carbon dioxide extractor, filtering, roughly separating, and concentrating to obtain an extract A;
a2: separating the extract A with normal phase chromatography filler and reverse phase chromatography filler to obtain effective components bisabolol and cannabidiol;
a3: the bisabolol is enriched to the content of 0.1-15 percent and the cannabidiol content of 10-80 percent, and the special cannabis sativa leaf extract enriched with the bisabolol and the cannabidiol is obtained.
2. An anti-inflammatory spot removing vanishing cream as claimed in claim 1, wherein: the paint comprises the following components in parts by weight: 6-8 parts of white oil, 7-10 parts of white vaseline, 7-10 parts of glyceryl monostearate, 1-4 parts of hemp seed oil, 15-20 parts of lanolin, 5-8 parts of a special cannabis sativa leaf extract rich in bisabolol and cannabidiol, 0.1 part of vitamin E, 0.3 part of triethanolamine, 0.3 part of essence, 0.05 part of preservative and 40-60 parts of deionized water.
3. An anti-inflammatory spot removing vanishing cream as claimed in claim 2, wherein: the paint comprises the following components in parts by weight: 7-8 parts of white oil, 8-9 parts of white vaseline, 9-10 parts of glyceryl monostearate, 3-4 parts of hemp seed oil, 20-25 parts of lanolin, 5-6 parts of a special hemp leaf extract rich in bisabolol and cannabidiol, 0.1 part of vitamin E, 0.3 part of triethanolamine, 0.3 part of essence, 0.05 part of preservative and 40-47 parts of deionized water.
4. The preparation method of the anti-inflammatory freckle-removing vanishing cream is characterized by comprising the following steps: the method comprises the following steps:
s0: white oil, white vaseline, glyceryl monostearate, hemp seed oil, lanolin, special cannabis sativa leaf extract rich in bisabolol and cannabidiol, and vitamin E are used as component A, triethanolamine and deionized water are used as component B, and essence and antiseptic are used as component C;
s1: heating the component A to 60-80 ℃ and keeping the temperature constant;
s2: heating the component B to 60-80 ℃ and keeping the temperature constant;
s3: slowly adding the component A into the component B under the condition of continuous stirring, and fully mixing and emulsifying the two components;
s4: under the condition of continuous stirring, when the temperature is reduced to 35-55 ℃, adding the component C, and continuously stirring to fully mix and emulsify all the components;
s5: cooling to room temperature, and bottling;
the extraction method of the special cannabis sativa leaf extract rich in bisabolol and cannabidiol comprises the following steps:
a1: selecting industrial hemp leaves, drying at 105 ℃, crushing, extracting by using a supercritical carbon dioxide extractor, filtering, roughly separating, and concentrating to obtain an extract A;
a2: separating the extract A with normal phase chromatography filler and reverse phase chromatography filler to obtain effective components bisabolol and cannabidiol;
a3: the bisabolol is enriched to the content of 0.1-15 percent and the cannabidiol content of 10-80 percent, and the special cannabis sativa leaf extract enriched with the bisabolol and the cannabidiol is obtained.
5. The method for preparing an anti-inflammatory spot-removing vanishing cream according to claim 4, which is characterized in that: the component A comprises, by weight, 5-8 parts of white oil, 7-12 parts of white vaseline, 7-13 parts of glyceryl monostearate, 1-9 parts of hemp seed oil, 15-25 parts of lanolin, 3-8 parts of a special hemp leaf extract rich in bisabolol and cannabidiol, and 0-0.2 part of vitamin E.
6. The method for preparing an anti-inflammatory spot-removing vanishing cream according to claim 4, which is characterized in that: the component B comprises 0.2-0.3 part of triethanolamine and 30-60 parts of deionized water in parts by weight.
7. The method for preparing an anti-inflammatory spot-removing vanishing cream according to claim 4, which is characterized in that: the component C comprises 0.2-0.3 part of essence and 0.03-0.05 part of preservative by weight.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711023963.3A CN107811904B (en) | 2017-10-27 | 2017-10-27 | Anti-inflammatory freckle-removing vanishing cream and preparation method thereof |
Applications Claiming Priority (1)
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022223099A1 (en) * | 2021-04-19 | 2022-10-27 | Symrise Ag | Compositions comprising cannabidiol and, optionally, bisabolol |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10239808B1 (en) | 2016-12-07 | 2019-03-26 | Canopy Holdings, LLC | Cannabis extracts |
| EP3745884A1 (en) | 2018-01-31 | 2020-12-09 | Canopy Holdings, Llc | Hemp powder |
| US11040932B2 (en) | 2018-10-10 | 2021-06-22 | Treehouse Biotech, Inc. | Synthesis of cannabigerol |
| DE202021103593U1 (en) * | 2021-07-05 | 2021-08-10 | Merlin Apotheke am Hochhaus Ruth Gebhardt & Dr. Frank Ullrich OHG | Skin-friendly, caring and protective agent for application to the skin |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009039843A2 (en) * | 2007-09-26 | 2009-04-02 | Letzel Heinz | Plant extract from low-thc cannabis for the treatment of disease |
| KR101500191B1 (en) * | 2013-11-12 | 2015-03-09 | 허경 | Skin care compositions and method for manufacturing the same |
| CN105796450A (en) * | 2014-12-30 | 2016-07-27 | 胡衍栋 | Apple oil vanishing cream |
| KR20160121268A (en) * | 2015-04-10 | 2016-10-19 | 디랑(주) | Anti-aging composition comprising Cannabis satica extract |
| CN106232130A (en) * | 2014-03-21 | 2016-12-14 | St&T国际股份有限公司 | Fructus Cannabis extracting method and compositions |
| WO2017055619A1 (en) * | 2015-09-30 | 2017-04-06 | Bionorica Ethics Gmbh | Vacuum distillation for enriching cannabidiol |
-
2017
- 2017-10-27 CN CN201711023963.3A patent/CN107811904B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009039843A2 (en) * | 2007-09-26 | 2009-04-02 | Letzel Heinz | Plant extract from low-thc cannabis for the treatment of disease |
| KR101500191B1 (en) * | 2013-11-12 | 2015-03-09 | 허경 | Skin care compositions and method for manufacturing the same |
| CN106232130A (en) * | 2014-03-21 | 2016-12-14 | St&T国际股份有限公司 | Fructus Cannabis extracting method and compositions |
| CN105796450A (en) * | 2014-12-30 | 2016-07-27 | 胡衍栋 | Apple oil vanishing cream |
| KR20160121268A (en) * | 2015-04-10 | 2016-10-19 | 디랑(주) | Anti-aging composition comprising Cannabis satica extract |
| WO2017055619A1 (en) * | 2015-09-30 | 2017-04-06 | Bionorica Ethics Gmbh | Vacuum distillation for enriching cannabidiol |
Non-Patent Citations (1)
| Title |
|---|
| 汉麻叶活性成分及其药理特性的研究概况;杜军强 等;《中国医药导报》;20111130;第8卷(第31期);第9-11页 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022223099A1 (en) * | 2021-04-19 | 2022-10-27 | Symrise Ag | Compositions comprising cannabidiol and, optionally, bisabolol |
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