CN107625825A - A kind of frost-cracking-preventing cream and preparation method thereof - Google Patents
A kind of frost-cracking-preventing cream and preparation method thereof Download PDFInfo
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- CN107625825A CN107625825A CN201710819029.6A CN201710819029A CN107625825A CN 107625825 A CN107625825 A CN 107625825A CN 201710819029 A CN201710819029 A CN 201710819029A CN 107625825 A CN107625825 A CN 107625825A
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Abstract
The invention provides a kind of frost-cracking-preventing cream, and it is made up of the component of following parts by weight：13 parts of P-Cymene, come 25 parts of lemon peel essential oil, 10 16 parts of emulsifying agent, 15 25 parts of water, 15 20 parts of vaseline, 5 10 parts of animal oil, 0.5 1 parts of preservative, 24 parts of NMF.Present invention also offers the preparation method of the frost-cracking-preventing cream.Frost-cracking-preventing cream provided by the present invention has good frost-cracking-preventing, functions of detumescence, relieving inflammation, antiallergy effect and cold-resistant stability.
Description
Technical field
The present invention relates to a kind of frost-cracking-preventing cream and preparation method thereof.
Background technology
Pernio and chap belong to physics dermatoses, and pernio typically occurs in the exposure portions such as finger, toe, ear, nose, by low temperature
There is purple plague purpura, oedema, inflammation after influenceing in cold, and heat is then itched, and severe one is blistered, and ulcer and pain are easily to send out cold season in winter
Frequently-occurring disease, taken a turn for the better with warm season, but be easy to recur in winter.Chap refers to occur in finger, toe, facies palmaris, heel
It is a kind of skin of dry skin caused by a variety of causes and linear parting Deng the short crack differed of depth Length discrepancy at skin
Disease, it is common frequently-occurring disease skin disease, it is common with autumn and winter.
Chinese patent application CN201710165265.0 discloses bursting by freezing nanometer emulsifiable paste, is to belong to modern Chinese herbal medicine cosmetics to receive
Rice milk cream prepare production technical field, be by Lasiosphaera fenzlii pallas pit viper oil, safflower pseudo-ginseng, Chinese cassia tree Asian puccoon, apricot glue Chinese gall, the cassia twig red sage root,
The achene of Siberian cocklebur, root of Chinese clematis natural plants nanometer emulsifiable paste composition.The invention can not effectively give play to frost-cracking-preventing effect, and cold-resistant stable
Property is bad.
The content of the invention
The technical problem to be solved in the present invention is to provide a kind of frost-cracking-preventing cream, its have good frost-cracking-preventing, functions of detumescence, relieving inflammation,
Antiallergy effect and cold-resistant stability.
In order to solve the above technical problems, the technical scheme is that：
A kind of frost-cracking-preventing cream, it is made up of the component of following parts by weight：P-Cymene 1-3 parts, carry out lemon peel essential oil 2-5 parts,
Emulsifying agent 10-16 parts, water 15-25 parts, vaseline 15-20 parts, animal oil 5-10 parts, preservative 0.5-1 parts, NMF 2-4 parts.
Further, the preparation process of the P-Cymene is：
Folium artemisiae argyi crushed after being dried to 50 mesh is obtained into Folium Artemisiae Argyi powder, with 1:Folium Artemisiae Argyi powder is added ultra-pure water by 18g/mL solid-to-liquid ratio
In, immersion loads onto fractionating device after 4 hours, and steam distillation is extracted 3 hours after electrical heating to reflux temperature, the extraction that will be obtained
Thing obtains P-Cymene after being dehydrated with anhydrous sodium sulfate.
Further, it is described come lemon peel essential oil preparation process be：
Lemon skin was placed in vacuum refrigeration device and dried 10 hours future, and 50 mesh are crushed to after taking-up must arrive lemon skin powder, in the future
Lemon skin powder is added in extraction kettle, and opening carbon dioxide steel cylinder is supplied gas with 20L/h flow velocity reaches 25MPa to pressure, is heated to 45
Supercritical extract must arrive lemon peel essential oil for 1.5 hours after DEG C.
Further, the emulsifying agent is 3 by weight ratio:1 ceteareth -25 and mannose erythrose alcohol ester
Mix.
Further, the water is deionized water.
Further, the vaseline is albolene.
Further, the animal oil is sheep oil.
Further, the preservative is sorbic acid.
Further, the NMF is propane diols.
Another technical problem to be solved by the present invention is that provide the preparation method of above-mentioned frost-cracking-preventing cream.
In order to solve the above technical problems, technical scheme is：
A kind of preparation method of frost-cracking-preventing cream, comprises the following steps：
(1) each component is weighed according to parts by weight, is placed in after vaseline, emulsifying agent, water are well mixed in homogeneous mixer,
Stir 3 minutes, be then transferred under high pressure Microfluidizer 10kbar pressure under 1500rpm rotating speeds after being heated to 70-80 DEG C
3 obtained mixed emulsions of matter；
(2) it will be added after animal oil heating fusing in mixed emulsion made from step (1), and stir to after being well mixed and cool
To less than 50 DEG C, addition P-Cymene, continue stirring to well mixed, room temperature cooling after coming lemon peel essential oil, preservative, NMF
Frost-cracking-preventing cream is obtained after into paste.
Compared with prior art, the invention has the advantages that：
1) folium artemisiae argyi is the leaf of composite family artemisia herbaceous plant Chinese mugwort, and rich in polysaccharide, flavones, tannin isoreactivity composition, the present invention will
P-Cymene is made by steam distillation in folium artemisiae argyi, and it can effectively alleviate pernio and its caused symptom in a short time, right
The skin of chap can also play a part of the myogenic that heals in a short time, therefore have good frost-cracking-preventing effect, in addition folium artemisiae argyi
Essential oil also has good functions of detumescence, relieving inflammation effect.
2) skin portion that lemon skin takes lemon is carried out, the present invention passes through the oil in supercritical carbon dioxide extraction method lemon in future skin
Shape active component extracts the lemon peel essential oil that must arrive, and it has good anti-inflammation detumescence activity, therefore can further improve anti-
Functions of detumescence, relieving inflammation effect of bursting by freezing cream；In addition, carrying out lemon peel essential oil also has good antiallergic activity and excellent cold tolerance, because
This can effectively improve antiallergy effect of frost-cracking-preventing cream and cold-resistant stability.
3) mannose erythrose alcohol ester is a kind of natural surfactant, and it has good emulsifiability and cold resistance
Can, thus can further improve the cold-resistant stability of frost-cracking-preventing cream so that frost-cracking-preventing cream can also be sent out for a long time in cold environment
Shoot effect；In addition, mannose erythrose alcohol ester has antibacterial bacteriostatic active, effectively skin can be avoided to be influenceed by anaphylactogen,
Therefore antiallergy effect of frost-cracking-preventing cream can also further be improved.
Embodiment
The present invention is described in detail below in conjunction with specific embodiment, herein schematic description and description of the invention
For explaining the present invention, but it is not as a limitation of the invention.
Embodiment 1-4
Frost-cracking-preventing cream is prepared (in terms of parts by weight) according to the ratio of table 1：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | |
| P-Cymene | 1 | 3 | 2 | 2.5 |
| Carry out lemon peel essential oil | 3 | 2 | 4 | 5 |
| Ceteareth -25 | 7.5 | 10.5 | 9 | 12 |
| Mannose erythrose alcohol ester | 2.5 | 3.5 | 3 | 4 |
| Deionized water | 18 | 25 | 20 | 15 |
| Albolene | 15 | 16 | 18 | 20 |
| Sheep oil | 10 | 9 | 8 | 5 |
| Sorbic acid | 1 | 0.5 | 0.8 | 0.9 |
| Propane diols | 2.5 | 2 | 3 | 4 |
Table 1
Embodiment 1-4 preparation method comprises the following steps：
(1) folium artemisiae argyi crushed after being dried to 50 mesh is obtained into Folium Artemisiae Argyi powder, with 1:18g/mL solid-to-liquid ratio adds Folium Artemisiae Argyi powder super
In pure water, immersion loads onto fractionating device after 4 hours, and steam distillation is extracted 3 hours after electrical heating to reflux temperature, by what is obtained
Extract obtains P-Cymene after being dehydrated with anhydrous sodium sulfate；
(2) lemon in future skin is placed in vacuum refrigeration device and dried 10 hours, and 50 mesh are crushed to after taking-up must arrive lemon skin powder, will
Carry out lemon skin powder to add in extraction kettle, opening carbon dioxide steel cylinder is supplied gas with 20L/h flow velocity reaches 25MPa to pressure, is heated to
Supercritical extract must arrive lemon peel essential oil for 1.5 hours after 45 DEG C；
(3) each component is weighed according to parts by weight, is 3 by albolene, by weight ratio:1 ceteareth -25 and
It is placed in after emulsifying agent that mannose erythrose alcohol ester mixes, deionized water are well mixed in homogeneous mixer, is heated to 70-
Stirred 3 minutes under 1500rpm rotating speeds after 80 DEG C, be then transferred under high pressure Microfluidizer 10kbar pressure homogeneous and be made for 3 times
Mixed emulsion；
(4) it will be added after sheep oil heating fusing in mixed emulsion made from step (1), and stir to after being well mixed and be cooled to
Less than 50 DEG C, addition P-Cymene, continue stirring to being well mixed after coming lemon peel essential oil, sorbic acid, propane diols, room temperature is cooled to
Frost-cracking-preventing cream is obtained after paste.
Comparative Examples 1
Do not include P-Cymene in component, other components and preparation method are same as Example 3.
Comparative Examples 2
Do not include carrying out lemon peel essential oil in component, other components and preparation method are same as Example 3.
Comparative Examples 3
Do not include mannose erythrose alcohol ester in component, other components and preparation method are same as Example 3.
Comparative example
Comparative example is the embodiment 1 of Application No. CN201710165265.0 Chinese patent.
Experimental example one：Frost-cracking-preventing efficacy test
100 pernio chap patients are chosen, everyone behind affected part 1 time, two weeks is applied to using frost-cracking-preventing cream before falling asleep daily
Pernio chap effect is evaluated, 1 point represents almost have an effect, and 2 points represent pernio mitigations, there is part healing at chap, 3
Divide and represent that pernio disappears, healed at chap, calculate frost-cracking-preventing effect average mark, test result is as shown in table 2：
| Frost-cracking-preventing effect average mark | |
| Embodiment 1 | 2.7 |
| Embodiment 2 | 2.7 |
| Embodiment 3 | 2.8 |
| Embodiment 4 | 2.7 |
| Comparative Examples 1 | 0.5 |
| Comparative Examples 2 | 2.7 |
| Comparative Examples 3 | 2.6 |
| Comparative example | 2.0 |
Table 2
As seen from Table 2, it is many to be above comparative example for 1-4 of embodiment of the present invention frost-cracking-preventing effect average mark, shows this
Inventing has good frost-cracking-preventing effect, and frost-cracking-preventing effect of wherein embodiment 3 is best.Comparative Examples 1-3 constituent part
It is different from embodiment 3, wherein the biggest drop of the frost-cracking-preventing effect average mark of Comparative Examples 1, illustrate P-Cymene to antifreeze
The influence for splitting effect is very big；The frost-cracking-preventing effect average mark and embodiment 1-4 of Comparative Examples 2,3 maintain an equal level, and illustrate to carry out lemon skin
Essential oil and mannose erythrose alcohol ester do not influence substantially on frost-cracking-preventing effect.
Experimental example two：Functions of detumescence, relieving inflammation efficacy test
Choosing 100 skins has the subject of swelling inflammation, is seen after being applied to affected part 1 time, 5 days using frost-cracking-preventing cream daily
Examine affected part situation, calculate functions of detumescence, relieving inflammation effective percentage, functions of detumescence, relieving inflammation effective percentage=functions of detumescence, relieving inflammation efficiently individual quantity/total number of persons ×
100%, test result is as shown in table 3：
| Functions of detumescence, relieving inflammation effective percentage (%) | |
| Embodiment 1 | 89 |
| Embodiment 2 | 90 |
| Embodiment 3 | 91 |
| Embodiment 4 | 88 |
| Comparative Examples 1 | 76 |
| Comparative Examples 2 | 78 |
| Comparative Examples 3 | 89 |
| Comparative example | 32 |
Table 3
As seen from Table 3, it is many to be above comparative example for 1-4 of embodiment of the present invention functions of detumescence, relieving inflammation effective percentage, shows this hair
Bright have good functions of detumescence, relieving inflammation effect, and functions of detumescence, relieving inflammation effect of wherein embodiment 3 is best.Comparative Examples 1-3 part group
Point different from embodiment 3, the functions of detumescence, relieving inflammation effective percentage of Comparative Examples 1,2 has to be declined by a small margin, is illustrated P-Cymene, is taken lemon
Peel essential oil can effectively improve functions of detumescence, relieving inflammation effect；The functions of detumescence, relieving inflammation of Comparative Examples 3 is efficient to maintain an equal level with embodiment 1-4, says
Bright mannose erythrose alcohol ester offsets swollen anti-inflammatory efficacy not to be influenceed substantially.
Experimental example three：Antiallergy efficacy test
Choosing 100 skins has the subject of allergic symptom, is seen after being applied to affected part 1 time, 5 days using frost-cracking-preventing cream daily
Affected part situation is examined, calculates antiallergy effective percentage, antiallergy effective percentage=antiallergy efficiently individual quantity/total number of persons × 100%, test
As a result it is as shown in table 4：
| Antiallergy effective percentage (%) | |
| Embodiment 1 | 89 |
| Embodiment 2 | 88 |
| Embodiment 3 | 90 |
| Embodiment 4 | 87 |
| Comparative Examples 1 | 89 |
| Comparative Examples 2 | 70 |
| Comparative Examples 3 | 74 |
| Comparative example | 16 |
Table 4
As seen from Table 4, it is many to be higher by comparative example for 1-4 of embodiment of the present invention antiallergy effective percentage, shows the present invention
It is best with good antiallergy effect, antiallergy effect of wherein embodiment 3.Comparative Examples 1-3 constituent part and reality
The difference of example 3 is applied, the antiallergy of Comparative Examples 1 is efficient to maintain an equal level with embodiment 1-4, illustrates P-Cymene to antiallergy effect base
This does not influence；The antiallergy effective percentage of Comparative Examples 2,3 has to be declined by a small margin, illustrates to carry out lemon peel essential oil and mannose is red
Moss sugar alcohol ester can effectively improve antiallergy effect.
Experimental example four：Cold-resistant stability test
Each frost-cracking-preventing cream is placed in -10 DEG C of interior, taken out after 24 hours, frost-cracking-preventing cream is observed after clear-cutting forestland to room temperature
Surface change, test result is as shown in table 5：
| Embodiment 1 | Surface no significant difference |
| Embodiment 2 | Surface no significant difference |
| Embodiment 3 | Surface no significant difference |
| Embodiment 4 | Surface no significant difference |
| Comparative Examples 1 | Surface no significant difference |
| Comparative Examples 2 | There is caking phenomenon in surface, can not directly use |
| Comparative Examples 3 | There is caking phenomenon in surface, can not directly use |
| Comparative example | There is caking phenomenon in surface, can not directly use |
Table 5
As seen from Table 5,1-4 of the embodiment of the present invention cold-resistant stability is better than comparative example.Comparative Examples 1-3 portion
Packet point is different from embodiment 3, and the cold-resistant stability of wherein Comparative Examples 1 is suitable with embodiment 1-4, illustrates P-Cymene pair
Cold-resistant stability does not influence substantially；The cold-resistant stability of Comparative Examples 2,3 is poor as comparative example, illustrates to carry out lemon skin essence
Oil, mannose erythrose alcohol ester can effectively improve cold-resistant stability.
The above-described embodiments merely illustrate the principles and effects of the present invention, not for the limitation present invention.It is any ripe
Know the personage of this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause
This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as
Into all equivalent modifications or change, should by the present invention claim be covered.
Claims (10)
- A kind of 1. frost-cracking-preventing cream, it is characterised in that：It is made up of the component of following parts by weight：P-Cymene 1-3 parts, carry out lemon skin essence Oily 2-5 parts, emulsifying agent 10-16 parts, water 15-25 parts, vaseline 15-20 parts, animal oil 5-10 parts, preservative 0.5-1 parts, moisturizing Agent 2-4 parts.
- A kind of 2. frost-cracking-preventing cream according to claim 1, it is characterised in that：The preparation process of the P-Cymene is：Folium artemisiae argyi crushed after being dried to 50 mesh is obtained into Folium Artemisiae Argyi powder, with 1:18g/mL solid-to-liquid ratio adds Folium Artemisiae Argyi powder in ultra-pure water, Immersion loads onto fractionating device after 4 hours, and steam distillation is extracted 3 hours after electrical heating to reflux temperature, the extract that will be obtained P-Cymene is obtained after being dehydrated with anhydrous sodium sulfate.
- A kind of 3. frost-cracking-preventing cream according to claim 2, it is characterised in that：It is described come lemon peel essential oil preparation process be：Lemon skin was placed in vacuum refrigeration device and dried 10 hours future, and 50 mesh are crushed to after taking-up must arrive lemon skin powder, future lemon skin Powder is added in extraction kettle, and opening carbon dioxide steel cylinder is supplied gas with 20L/h flow velocity reaches 25MPa to pressure, after being heated to 45 DEG C Supercritical extract must arrive lemon peel essential oil for 1.5 hours.
- A kind of 4. frost-cracking-preventing cream according to claim 3, it is characterised in that：The emulsifying agent is 3 by weight ratio:1 whale Wax stereth -25 and mannose erythrose alcohol ester mix.
- A kind of 5. frost-cracking-preventing cream according to claim 4, it is characterised in that：The water is deionized water.
- A kind of 6. frost-cracking-preventing cream according to claim 5, it is characterised in that：The vaseline is albolene.
- A kind of 7. frost-cracking-preventing cream according to claim 6, it is characterised in that：The animal oil is sheep oil.
- A kind of 8. frost-cracking-preventing cream according to claim 7, it is characterised in that：The preservative is sorbic acid.
- A kind of 9. frost-cracking-preventing cream according to claim 8, it is characterised in that：The NMF is propane diols.
- A kind of 10. preparation method of frost-cracking-preventing cream according to claim 1~9 any one, it is characterised in that：Including with Lower step：(1) each component is weighed according to parts by weight, is placed in homogeneous mixer, heats after vaseline, emulsifying agent, water are well mixed Stirred 3 minutes under 1500rpm rotating speeds after to 70-80 DEG C, be then transferred to homogeneous 3 times under high pressure Microfluidizer 10kbar pressure Mixed emulsion is made；(2) it will be added after animal oil heating fusing in mixed emulsion made from step (1), and stir and be cooled to 50 to after being well mixed Below DEG C, addition P-Cymene, continue stirring to being well mixed after coming lemon peel essential oil, preservative, NMF, room temperature is cooled to cream Frost-cracking-preventing cream is obtained after shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710819029.6A CN107625825B (en) | 2017-09-12 | 2017-09-12 | Anti-frost crack paste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710819029.6A CN107625825B (en) | 2017-09-12 | 2017-09-12 | Anti-frost crack paste and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107625825A true CN107625825A (en) | 2018-01-26 |
| CN107625825B CN107625825B (en) | 2020-07-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710819029.6A Active CN107625825B (en) | 2017-09-12 | 2017-09-12 | Anti-frost crack paste and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN107625825B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536485A (en) * | 2013-10-18 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Hand cream for preventing chapped skin |
| CN203763364U (en) * | 2014-03-31 | 2014-08-13 | 梅向东 | Medical patch for chilblain prevention and treatment |
-
2017
- 2017-09-12 CN CN201710819029.6A patent/CN107625825B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536485A (en) * | 2013-10-18 | 2014-01-29 | 桂林雪芙莲日化有限公司 | Hand cream for preventing chapped skin |
| CN203763364U (en) * | 2014-03-31 | 2014-08-13 | 梅向东 | Medical patch for chilblain prevention and treatment |
Non-Patent Citations (2)
| Title |
|---|
| 无: "橘皮功能多多", 《双足与保健》 * |
| 李欣: ""冻" 人不美丽", 《课堂内外(初中版)》 * |
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| Publication number | Publication date |
|---|---|
| CN107625825B (en) | 2020-07-28 |
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