CN106074663A - One Plant Extracts and steroid-dependent dermatitis repair cream - Google Patents
One Plant Extracts and steroid-dependent dermatitis repair cream Download PDFInfo
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- CN106074663A CN106074663A CN201610718985.0A CN201610718985A CN106074663A CN 106074663 A CN106074663 A CN 106074663A CN 201610718985 A CN201610718985 A CN 201610718985A CN 106074663 A CN106074663 A CN 106074663A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
Abstract
The present invention relates to cosmetics of everyday use technical field, particularly to a Plant Extracts and steroid-dependent dermatitis repair cream.This plant extract includes close Luo Mu extract, burdock extract, Herba portulacae extract and Flos Lonicerae extract.The present invention uses the plant extracts such as close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract to substitute hormone, can alleviate skin damage, the most again can nourishes rough skin, antiallergic antiinflammatory；Not only improving and break away from the dependence to hormone, skin will not be brought extra burden by the most natural extract；Steroid-dependent dermatitis repair cream of the present invention solves that the responding time that other restorative procedures on the market exist is slow, dependency strong, recurrent exerbation and the problem cured the symptoms, not the disease.
Description
Technical field
The present invention relates to cosmetics of everyday use technical field, particularly to a Plant Extracts and steroid-dependent dermatitis reparation
Frost.
Background technology
In recent years, consumer, in order to pursue quick whitening, reparation and the effect such as anti-ageing, causes in effect type cosmetics
Illegally add hormone, heavy metal phenomenon of common occurrence.Such as: in whitening and freckle-removing product add hydroquinone, retinoic acid, fill in rice
Pine or the heavy metal such as hydrargyrum, lead；Dexamethasone, hydrocortisone etc. is used in antiallergic product；Chlorine is added in product for resolving poxes
Mycin etc.；Even some common mask product uses glucocorticoid in a large number in order to reduce allergy rate.In this case, swash
Element dependence facial dermatitis patient is geometry times growth trend.Steroid-dependent dermatitis is because the prolonged and repeated hormone of external improperly causes
Dermatitis.After showing as external glucocorticoid, primary skin lesion disappears, but occurs again inflammatory damage after disabling, and needs Reusability sugar
17-hydroxy-11-dehydrocorticosterone is to control symptom a kind of dermatitis gradually increased the weight of.The metabolism of skin can be suppressed after life-time service hormone, make
Base cell splitting rate slows down, cuticular lipid and protein metabolism are substantially at repressed state, so can make angle
Matter confluent monolayer cells is more and more thinner, and skin loses protective layer, can induce a series of dermatosis.In recent years, morbidity is in rising year by year
Trend, obstinate refractory is more.Therefore, the demand for the product for the treatment of steroid-dependent dermatitis is extremely urgent.
The method of main solution steroid-dependent dermatitis the most on the market includes: 1) hormone Subtraction method, this method is
Being continuing with hormone, simply slowly reduce the usage amount of hormone, the healing cycle of this method is oversize；2) mineral water cold compress,
This method can only the discomfort of respite skin, it is impossible to fundamentally solving steroid-dependent dermatitis, index is not effected a permanent cure；3) change
Cosmetic interpolation has to be alleviated or the material for the treatment of steroid-dependent dermatitis effect, main employing " mist cooling ", " antiinflammatory desensitization ",
The method " promoting that epidermis produces ", these methods are owing to therapy approach is single or not comprehensively, causes curative effect slow, takes effect not
Enough obvious.Accordingly, it is desirable to provide it is a kind of without hormone, the skin care item that can effectively treat steroid-dependent dermatitis.
Summary of the invention
In view of this, the invention provides a Plant Extracts and steroid-dependent dermatitis repair cream.This plant extract
Thing can replace hormone to be added in skin care item；This repair cream can effectively treat steroid-dependent dermatitis.
In order to realize foregoing invention purpose, the present invention provides techniques below scheme:
The invention provides a Plant Extracts, including close Luo Mu extract, burdock extract, Herba portulacae extract and
Flos Lonicerae extract.
The present invention uses plant extract close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae to extract
Thing.Close Luo Mu extract is unique a kind of xylophyta revivable plant, its leaf and extraction of stem in the environment of arid
Thing is to inflammation, the curative effect of mystery of burning, scald.It can protect the formation of cell protein, self antioxidation of active cell
System, can detect the change of cell water content simultaneously, supplement enough moisture to cell.Burdock extract treatment skin is done
Dry, severe pruritus, inflammation, the symptom such as cicatrix, can suppress the inflammation caused because of a variety of causes (outside stimulus or genetic factor) simultaneously
Inflammation factor, significantly improves immunocompetence and the antioxidant activity of skin self, has the effect releiving and repairing skin；Herba Portulacae carries
Take thing and be also referred to as Herba Angelicae Keiskei in China, rich in having substantial amounts of flavonoid, adrenin, polysaccharide and various vitamin, aminoacid
Deng compound, skin allergy, stimulation, antiinflammatory are had good curative effect, especially life-time service hormones cosmetics are produced
Skin allergy has obvious anti-allergic effects.Medically can treat skin sore and furuncle and purulent disease, to eczema, dermatitis rhus, skin
Inflammation, skin pruritus and pain have extraordinary curative effect.Flos Lonicerae extract can wind-dispelling heat-dissipating can also removing summer-heat blood poison, alleviate hormone
Face that dependence facial dermatitis brings is scorching hot the symptom such as itches.Close Luo Mu extract, burdock extract, Herba Portulacae are extracted by the present invention
Thing, Flos Lonicerae extract are with the use of rear, and it has more preferable effect in terms for the treatment of or alleviation steroid-dependent dermatitis.
As preferably, in parts by weight, plant extract includes close Luo Mu extract 0.5～2 parts, burdock extract 0.5
～1.5 parts, Herba portulacae extract 0.5～1.5 parts and Flos Lonicerae extract 0.5～1.5 parts.
As preferably, this plant extract also includes Herba Saussureae Involueratae extract and/or Sargassum extract.
Present invention also offers this plant extract and in preparation treatment or alleviate steroid-dependent dermatitis medicine or skin care item
In application.
Present invention also offers a kind of steroid-dependent dermatitis repair cream, including emulsifying agent, Vegetable oil lipoprotein, horny layer reparation
Agent, cell nutrient solution, wetting agent, nanometer silver, close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract
And solvent.
The present invention uses nanometer silver to replace hormone as antiinflammatory desensitizer, plant extract, supplement cell horny layer simultaneously
Required fatty acid, the nutritional solution of base cell is comprehensive makes a hormonal dependent that the speed that takes effect is fast, curative effect is good
Dermatitis repair cream.
As preferably, emulsifying agent is hydrolecithin, distearyl acid polyglycerin ester-10, hydroxypropyl double lauramide, spermaceti
One or more in stearyl alcohol, behenyl alcohol；
Preferably, emulsifying agent is hydrolecithin, distearyl acid polyglycerin ester-10 and behenyl alcohol.Hydrolecithin, two hard
Fat acid polyglycerin ester-10 has the structure that same epidermis is the most similar with the blend system of behenyl alcohol, has good screen to skin
Cover effect, the most beneficially the infiltration of effective ingredient, be also equipped with good moistening effect simultaneously and product uses sense, be equivalent to crisp
Weak epidermis wears the soft coat of last layer.The emulsifying agent using this gentleness can reduce skin irritation and injury.
As preferably, Vegetable oil lipoprotein be a kind of in Oleum Vitis viniferae, Jojoba oil, camellia seed oil, Semen pruni armeniacae oil, olive oil or
Several；
Preferably, Vegetable oil lipoprotein is Oleum Vitis viniferae and Jojoba oil.
As preferably, horny layer renovation agent is that plant sterol ester, cetearyl alcohol, ceramide, vitamin E, green tea carry
Take one or more in thing, Aloe extract, Flos Chrysanthemi extract, Fructus Cucumidis sativi extract；
Preferably, horny layer renovation agent is that plant sterol ester, cetearyl alcohol, ceramide, vitamin E and green tea extract
Thing.By adding the compositions such as phytosterols oletate, ceramide and vitamin e, can quickly repair lipid between horn cell；Green
The catechin contained in tea extract can stimulate the propagation of ageing skin epidermal keratinocyte, green tea polyphenol protection Skin Cell
From the injury of ultraviolet, there is anti-inflammatory effect.
As preferably, cell nutrient solution is acetyl group tetrapeptide-5, soluble protein polysaccharide, beta glucan, Argireline, collagen
One or more in albumen；
Preferably, cell nutrient solution is acetyl group tetrapeptide-5 and soluble protein polysaccharide.Acetyl group tetrapeptide-5 is that skin is done
The activator of cell, can activate stem cell, activation Skin Cell, stimulate fibroblast to produce collagen, suppress collagenase to live
Property.Soluble protein polysaccharide provides the enough nutrition needed for epidermal growth, accelerates the recovery of whole epidermal tissue.
As preferably, wetting agent is glycerol, methyl propanediol, 1,3 butanediols, propylene glycol, hyaluronate sodium, aminoacid guarantor
One or more in humectant；
Preferably, wetting agent is glycerol, methyl propanediol, hyaluronate sodium and amino acid humectant.Hyaluronate sodium and
Amino acid humectant is nature moisturizing factor, it is provided that the moisture that horn cell is sufficient, recovers skin barrier function from inside to outside.
The present invention uses nanometer silver as antibacterial, preferable preservative efficacy can be had simultaneously will not to bring any thorn
Swash.Nanometer silver has a bactericidal anti-inflammatory effect of high-efficiency broad spectrum, and permeability is high, antibacterial persistently, use nanometer prepared by nanotechnology
Silver gradually can discharge in system；Nanometer silver also has good biocompatibility simultaneously, it is possible to promotes wound healing, improves wound
The microcirculation of tissue, helps antiallergic antiinflammatory.
As preferably, solvent is water.
As preferably, steroid-dependent dermatitis repair cream includes: hydrolecithin, distearyl acid polyglycerin ester-10, behenyl
Alcohol, Oleum Vitis viniferae, Jojoba oil, plant sterol ester, cetearyl alcohol, ceramide, vitamin E, green tea extract, water, sweet
Oil, methyl propanediol, hyaluronate sodium, close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract, ammonia
Base acid wetting agent, acetyl group tetrapeptide-5, soluble protein polysaccharide and nanometer silver.
As preferably, in terms of weight/mass percentage composition, steroid-dependent dermatitis repair cream includes: hydrolecithin 1%～
3%, distearyl acid polyglycerin ester-10 0.3%～0.5%, behenyl alcohol 0.5%～1%, Oleum Vitis viniferae 4%～8%, Jojoba
Oil 4%～8%, plant sterol ester 1%～5%, cetearyl alcohol 0.2%～3%, ceramide 0.02%～0.5%, dimension is raw
Element E 0.2%～1%, green tea extract 0.1%～0.5%, acetyl group tetrapeptide-5 0.8%～2%, soluble protein polysaccharide
1%～2%, glycerol 4%～10%, methyl propanediol 1%～5%, hyaluronate sodium 0.1%～1%, amino acid humectant
1%～2%, close Luo Mu extract 0.5%～2%, burdock extract 0.5%～1.5%, Herba portulacae extract 0.5%～
1.5%, Flos Lonicerae extract 0.5%～1.5%, nanometer silver 0.2%～1%, water is supplied.
In the embodiment that the present invention provides, hydrolecithin 1.5%～2%, distearyl acid polyglycerin ester-100.3%
～0.5%, behenyl alcohol 0.5%～1%, Oleum Vitis viniferae 4%～6%, Jojoba oil 4%～5%, plant sterol ester 1%～
1.5%, cetearyl alcohol 0.8%～1%, ceramide 0.1%～0.2%, vitamin E 0.3%～0.5%, green tea extracts
Thing 0.2%～0.3%, acetyl group tetrapeptide-5 0.8%～1.0%, soluble protein polysaccharide 1%～1.2%, glycerol 4%～
5%, methyl propanediol 1%～2%, hyaluronate sodium 0.1%～0.3%, amino acid humectant 1%, close Luo Mu extract
0.6%～0.8%, burdock extract 0.8%～1.0%, Herba portulacae extract 0.8%～1.0%, Flos Lonicerae extract
0.8%～1.0%, nanometer silver 0.5%～0.6%, water is supplied.
Present invention also offers the preparation method of this steroid-dependent dermatitis repair cream, including: by emulsifying agent, vegetable oil
Fat, horny layer renovation agent, cell nutrient solution, wetting agent, nanometer silver, close Luo Mu extract, burdock extract, Herba Portulacae are extracted
Thing, Flos Lonicerae extract mix with solvent, obtain steroid-dependent dermatitis repair cream.
As preferably, emulsifying agent is hydrolecithin, distearyl acid polyglycerin ester-10 and behenyl alcohol, and Vegetable oil lipoprotein is Portugal
Grape seed oil and Jojoba oil, horny layer renovation agent is that plant sterol ester, cetearyl alcohol, ceramide, vitamin E and green tea carry
Taking thing, cell nutrient solution is acetyl group tetrapeptide-5 and soluble protein polysaccharide, and wetting agent is glycerol, methyl propanediol, hyalomitome
Acid sodium and amino acid humectant, solvent is water；Its preparation method is:
1) hydrolecithin, distearyl acid polyglycerin ester-10, behenyl alcohol, Oleum Vitis viniferae, Jojoba oil, plant sterol ester,
Cetearyl alcohol, ceramide, vitamin E are mixed and heated to 80 DEG C, obtain oil phase；
2) water, glycerol, methyl propanediol, hyaluronate sodium are mixed and heated to 85 DEG C, homogenizing, dispersed with stirring is uniform,
To aqueous phase；
3) oil phase is mixed with water, homogenizing, continuously stirred cooling；
4) close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extraction are added after being cooled to 45 DEG C
Thing, green tea extract, amino acid humectant, acetyl group tetrapeptide-5, soluble protein polysaccharide, nanometer silver stir, and filter.
The invention provides a Plant Extracts and steroid-dependent dermatitis repair cream.This plant extract includes close sieve
Wood extract, burdock extract, Herba portulacae extract and Flos Lonicerae extract.The present invention at least has one of following advantage:
1, the present invention uses the plants such as close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract
Extract substitutes hormone, can alleviate skin damage, the most again can nourishes rough skin, antiallergic antiinflammatory；Not only improve and break away from swashing
The dependence of element, skin will not be brought extra burden by the most natural extract；
2, steroid-dependent dermatitis repair cream of the present invention use nanometer silver is as main sterilization, antiinflammatory desensitizer, not only
Skin will not be caused extra burden, but also skin can be helped to heal faster, promote skin regeneration；Use nanometer silver
As main protective system, it is provided that the shelf-life of long period；
3, steroid-dependent dermatitis repair cream of the present invention has preferable antiinflammatory, itching-relieving action, it is possible to effectively treat hormone
Dependence facial dermatitis, and good stability, solve that the responding time that other restorative procedures on the market exist is slow, dependency strong, anti-
The problem that recurrence is made and cured the symptoms, not the disease；
4, steroid-dependent dermatitis repair cream of the present invention uses oil-in-water system, it is provided that can help while salubrious skinfeel
Help skin to form one layer of oil film, isolate external injury；
5, the present invention uses emulsifying agent and oils and fats are all from plant extract, will not cause extra burden to skin；
6, the form that steroid-dependent dermatitis repair cream of the present invention is prepared as cream makes patient easy to use, and does not has it
His abnormal flavour；
7, the preparation method technique of steroid-dependent dermatitis repair cream of the present invention is simple, pollution-free, is suitable for extensive raw
Produce.
Detailed description of the invention
The invention discloses a Plant Extracts and steroid-dependent dermatitis repair cream, those skilled in the art can borrow
Mirror present disclosure, is suitably modified technological parameter and realizes.Special needs to be pointed out is, all similar replacements and change are to this area
Being apparent from for technical staff, they are considered as being included in the present invention.Method and the application of the present invention have been passed through
Preferred embodiment is described, and related personnel substantially can be to described herein in without departing from present invention, spirit and scope
Methods and applications be modified or suitably change and combine, realize and apply the technology of the present invention.
Raw materials used or adjuvant Jun Keyou city in the plant extract of present invention offer and steroid-dependent dermatitis repair cream
Field is buied.
Close Luo Mu extract is the limited public affairs of same chemistry from Guangzhou Ao Xue Chemical Co., Ltd., burdock extract from Guangzhou
Department, Herba portulacae extract are from Guangzhou hundred Hao Bo company limited, Flos Lonicerae extract from the Guangzhou remittance limited public affairs of bright biotechnology
Department.
Below in conjunction with embodiment, the present invention it is expanded on further:
Embodiment 1
The present invention uses this 4 kinds plants of close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract
Thing extract replaces hormone, and the composition of concrete plant extract is as follows:
Plant extract 1: close Luo Mu extract 0.6 part, burdock extract 0.8 part, Herba portulacae extract 1 part, Flos Lonicerae
Extract 0.8 part；
Plant extract 2: close Luo Mu extract 0.5 part, burdock extract 1.5 parts, Herba portulacae extract 0.5 part, gold silver
Flower extract 1.5 parts；
Plant extract 3: close Luo Mu extract 2 parts, burdock extract 0.5 part, Herba portulacae extract 1.5 parts, Flos Lonicerae
Extract 0.5 part.
Using above-mentioned plant extract and each taste Chinese medicine extract to carry out the test of pesticide effectiveness, concrete test method is as follows:
Example steroid-dependent dermatitis patient being randomly divided into 8 groups and is randomly divided into 8 groups, wherein 1-7 group is treatment group, makes respectively
With plant extract 1, plant extract 2, plant extract 3, close Luo Mu extract, burdock extract, Herba portulacae extract, gold
Flos Lonicerae extract, is applied in face, pats to absorption, and using frequency is 2 times/d, each 2g；8th group is matched group, use gram
Department's ointment is not applied in face, and using frequency is 2 times/d.Wherein, it is 90d the course for the treatment of of 8 groups.After 90d, drug withdrawal 2d sees
Examine curative effect.
Result of the test is as follows:
Therapeutic evaluation: test the skin of face of volunteer respectively, test content includes redness, antipruritic, capillary tube
Expansion, xerosis cutis desquamation.Following four can be divided into according to result:
Recovery from illness: red and swollen, telangiectasis alleviates more than 90%, and gargalesthesia is wholly absent, xerosis cutis desquamation disappears；
Effective: red and swollen, telangiectasis alleviates more than 70%, and gargalesthesia disappears substantially, and xerosis cutis desquamation disappears substantially；
Effective: red and swollen, telangiectasis alleviates more than 50%, and gargalesthesia alleviates, and xerosis cutis desquamation alleviates；
Invalid: red and swollen, telangiectasis alleviates inconspicuous, and gargalesthesia alleviates inconspicuous, and xerosis cutis desquamation alleviates inconspicuous.
12 groups of patient clinical effectiveness comparison (%) of table
Result shows: treatment group has certain effect to steroid-dependent dermatitis.Wherein treatment group 1-3 relatively treatment group 4-
7 have more preferably therapeutic effect.
Embodiment 2
In the present embodiment, the steroid-dependent dermatitis repair cream Han nanometer silver includes following components:
Hydrolecithin 1.5%, distearyl acid polyglycerin ester-10 0.5%, behenyl alcohol 0.5%, Oleum Vitis viniferae 4%, suddenly
Bar oil 4% suddenly, plant sterol ester 1.5%, cetearyl alcohol 0.8%, ceramide 0.1%, vitamin E 0.3%, deionized water
74.3%, glycerol 4%, methyl propanediol 1.5%, hyaluronate sodium 0.1%, close Luo Mu extract 0.6%, burdock extract
0.8%, Herba portulacae extract 1%, Flos Lonicerae extract 0.8%, green tea extract 0.2%, amino acid humectant 1%, acetyl
Base tetrapeptide-51%, soluble protein polysaccharide 1%, nanometer silver 0.5%.
Its preparation method is: 1) hydrolecithin, distearyl acid polyglycerin ester-10, behenyl alcohol, Oleum Vitis viniferae, Jojoba
Oil, plant sterol ester, cetearyl alcohol, ceramide, vitamin E addition oil phase pot is heated to 80 DEG C of insulations standby；2) will
Deionized water, glycerol, methyl propanediol, hyaluronate sodium addition emulsifying pot is heated to 85 DEG C, homogenizing 5min, stirs 30min
Be uniformly dispersed, 3) by the material body slow suction emulsifying pot in oil phase pot, homogenizing 5min, continuously stirred cooling；4) it is cooled to
Close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract, green tea extract, ammonia it is separately added into after 45 DEG C
Base acid wetting agent, acetyl group tetrapeptide-5, soluble protein polysaccharide, nanometer silver stir；4) 200 mesh filter discharging.
Embodiment 3
In the present embodiment, the steroid-dependent dermatitis repair cream Han nanometer silver includes following components:
Hydrolecithin 1.8%, distearyl acid polyglycerin ester-10 0.3%, behenyl alcohol 0.6%, Oleum Vitis viniferae 4.5%,
Jojoba oil 5%, plant sterol ester 1%, cetearyl alcohol 0.8%, ceramide 0.15%, vitamin E 0.5%, deionization
Water 71.85%, glycerol 5%, methyl propanediol 1%, hyaluronate sodium 0.2%, close Luo Mu extract 0.8%, burdock extract
0.8%, Herba portulacae extract 0.8%, Flos Lonicerae extract 1%, green tea extract 0.3%, amino acid humectant 1%, acetyl
Base tetrapeptide-50.8%, soluble protein polysaccharide 1.2%, nanometer silver 0.6%.
Its preparation method is: 1) hydrolecithin, distearyl acid polyglycerin ester-10, behenyl alcohol, Oleum Vitis viniferae, Jojoba
Oil, plant sterol ester, cetearyl alcohol, ceramide, vitamin E addition oil phase pot is heated to 80 DEG C of insulations standby；2) will
Deionized water, glycerol, methyl propanediol, hyaluronate sodium addition emulsifying pot is heated to 85 DEG C, homogenizing 5min, stirs 30min
Be uniformly dispersed, 3) by the material body slow suction emulsifying pot in oil phase pot, homogenizing 5min, continuously stirred cooling；4) it is cooled to
Close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract, green tea extract, ammonia it is separately added into after 45 DEG C
Base acid wetting agent, acetyl group tetrapeptide-5, soluble protein polysaccharide, nanometer silver stir；4) 200 mesh filter discharging.
Embodiment 4
In the present embodiment, the steroid-dependent dermatitis repair cream Han nanometer silver includes following components:
Hydrolecithin 2%, distearyl acid polyglycerin ester-10 0.3%, behenyl alcohol 1%, Oleum Vitis viniferae 6%, Jojoba
Oil 5%, plant sterol ester 1%, cetearyl alcohol 1%, ceramide 0.2%, vitamin E 0.5%, deionized water 68.2%,
Glycerol 5%, methyl propanediol 2%, hyaluronate sodium 0.3%, close Luo Mu extract 0.8%, burdock extract 1%, Herba Portulacae
Extract 1%, Flos Lonicerae extract 0.8%, green tea extract 0.3%, amino acid humectant 1%, acetyl group tetrapeptide-
50.8%, soluble protein polysaccharide 1.2%, nanometer silver 0.6%.
Its preparation method is: 1) hydrolecithin, distearyl acid polyglycerin ester-10, behenyl alcohol, Oleum Vitis viniferae, Jojoba
Oil, plant sterol ester, cetearyl alcohol, ceramide, vitamin E addition oil phase pot is heated to 80 DEG C of insulations standby；2) will
Deionized water, glycerol, methyl propanediol, hyaluronate sodium addition emulsifying pot is heated to 85 DEG C, homogenizing 5min, stirs 30min
Be uniformly dispersed, 3) by the material body slow suction emulsifying pot in oil phase pot, homogenizing 5min, continuously stirred cooling；4) it is cooled to
Close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract, green tea extract, ammonia it is separately added into after 45 DEG C
Base acid wetting agent, acetyl group tetrapeptide-5, soluble protein polysaccharide, nanometer silver stir；4) 200 mesh filter discharging.
Embodiment 5
Test 1: embodiment 2-4 repair cream is carried out stability analysis
Concrete grammar is with reference to skin moistening cream QB/T 1857-2013 execution standard:
1, resistance to Thermal test: Example 2-4 dependence facial dermatitis repair cream is placed under 48 DEG C of environment, observes after standing 90 days；
2, cold-resistant test: Example 2-4 dependence facial dermatitis repair cream is placed under-10 DEG C of environment, observes after standing 90 days；
3, loop test: the dependence facial dermatitis repair cream that Example 2-4 produces is placed under 48 DEG C of environment, stands 12h；Again
Dependence facial dermatitis repair cream embodiment 2-4 produced is placed under-10 DEG C of environment；Continuously repeat this circulation three times.
Result of the test is as follows:
The stability of table 2 dependence facial dermatitis of the present invention repair cream
| Experiment group | Heat-resisting | Cold-resistant | Circulation |
| Embodiment 2 | Without layering | Without layering | Without layering |
| Embodiment 3 | Without layering | Without layering | Without layering |
| Embodiment 4 | Without layering | Without layering | Without layering |
Test 2: embodiment 2-4 is carried out antiphlogistic effects analysis
With xylol induced mice auricular concha edema as inflammatory model.Mice is divided into 5 groups, embodiment 2 groups, embodiment 3
Group, embodiment 4 groups, blank group (normal saline) and Butyl Flufenamate Ointment positive controls, then with 10g/KG's
Embodiment 2 groups, embodiment 3 groups, embodiment 4 groups, blank group (normal saline) and Butyl Flufenamate Ointment are coated with by dosage
Smear after the ear of mice.Observe repair cream and inflammation is caused the inhibitory action of swelling.
From experimental result, compareing with blank experiment group, embodiment 2-4 group has preferable inhibition to inflammation,
Through measure and data analysis obtain embodiment 2-4 and positive controls the suppression ratio of mice ear is respectively 39.25%,
42.35%, 46.87% and 27.56%.
Test 3: embodiment 2-4 is carried out antipruritic effect analysis
32 mices are randomly divided into 4 groups, embodiment 2 groups, embodiment 3 groups, embodiment 4 groups, blank group.According to
Repair cream is applied in the right metapedes of mice by the applying amount of 10g/KG, and matched group smears the distilled water of equivalent.After the 10min of interval, open
At wound surface Chu Di 0.01% histamine phosphate 0.05ml/ only begin, hereafter at interval of 3min successively with 0.01%, 0.02%,
0.03%, 0.04% increasing concen-trations, is only 0.05%ml/, until occurring that mice later adds right metapedes, to there is mice every time
When later licking foot to histamine's total amount be antipruritic threshold.Result of the test is as follows:
Table 3 antipruritic effect result of the test
| Group | Number of animals | Itch-threshold (μ g) |
| Matched group | 8 | 36.1 |
| Embodiment 2 | 8 | 356.5 |
| Embodiment 3 | 8 | 389.3 |
| Embodiment 4 | 8 | 400.2 |
From above-mentioned result of the test, relative to matched group, the embodiment of the present invention 2～4 repair cream has the most antipruritic
Inhibition.
Test 4: clinical effectiveness is tested
80 ages meet tested standard volunteer between 30-35 year, and random assortment is 4 groups, respectively embodiment 2
Group, embodiment 3 groups, embodiment 4 groups and matched group.Sooner or later using every day repair cream 0.3-0.5g to be applied to face, matched group uses
Same dosage Butyl Flufenamate Ointment, the use time is 90 days.
Therapeutic evaluation: test the skin of face of volunteer respectively, test content includes redness, antipruritic, capillary tube
Expansion, xerosis cutis desquamation.Following four can be divided into according to result:
Recovery from illness: red and swollen, telangiectasis alleviates more than 90%, and gargalesthesia is wholly absent, xerosis cutis desquamation disappears；
Effective: red and swollen, telangiectasis alleviates more than 70%, and gargalesthesia disappears substantially, skin
Dry desquamation disappears substantially；
Effective: red and swollen, telangiectasis alleviates more than 50%, and gargalesthesia alleviates, and xerosis cutis desquamation alleviates；
Invalid: red and swollen, telangiectasis alleviates inconspicuous, and gargalesthesia alleviates inconspicuous, and xerosis cutis desquamation alleviates inconspicuous.
Result of the test is as follows:
Table 4 clinical effectiveness is tested
Result shows: embodiment 2-4 has preferable curative effect to steroid-dependent dermatitis, with Butyl Flufenamate Ointment
Curative effect difference is inconspicuous.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a Plant Extracts, it is characterised in that include close Luo Mu extract, burdock extract, Herba portulacae extract and gold
Flos Lonicerae extract.
Plant extract the most according to claim 1, it is characterised in that in parts by weight, described plant extract includes
Close Luo Mu extract 0.5～2 parts, burdock extract 0.5～1.5 parts, Herba portulacae extract 0.5～1.5 parts and Flos Lonicerae extract
Thing 0.5～1.5 parts.
Plant extract the most according to claim 1 and 2, it is characterised in that described plant extract also includes that Herba Saussureae Involueratae carries
Take thing and/or Sargassum extract.
4. as according to any one of claims 1 to 3, plant extract in preparation treatment or alleviates steroid-dependent dermatitis medicine
Or the application in skin care item.
5. a steroid-dependent dermatitis repair cream, it is characterised in that include emulsifying agent, Vegetable oil lipoprotein, horny layer renovation agent, thin
Born of the same parents' nutritional solution, wetting agent, nanometer silver, solvent and plant extract as claimed any one in claims 1 to 3.
Steroid-dependent dermatitis repair cream the most according to claim 5, it is characterised in that described emulsifying agent is hydrogenation ovum phosphorus
One or more in fat, distearyl acid polyglycerin ester-10, hydroxypropyl double lauramide, cetearyl alcohol, behenyl alcohol；
Described Vegetable oil lipoprotein is one or more in Oleum Vitis viniferae, Jojoba oil, camellia seed oil, Semen pruni armeniacae oil, olive oil；
Described horny layer renovation agent is plant sterol ester, cetearyl alcohol, ceramide, vitamin E, green tea extract, Aloe
One or more in extract, Flos Chrysanthemi extract, Fructus Cucumidis sativi extract；
Described cell nutrient solution is in acetyl group tetrapeptide-5, soluble protein polysaccharide, beta glucan, Argireline, collagen protein
One or more；
Described wetting agent is in glycerol, methyl propanediol, 1,3 butanediols, propylene glycol, hyaluronate sodium, amino acid humectant
One or more；
Described solvent is water.
7. according to the steroid-dependent dermatitis repair cream described in claim 5 or 6, it is characterised in that described hormonal dependent skin
Scorching repair cream includes: hydrolecithin, distearyl acid polyglycerin ester-10, behenyl alcohol, Oleum Vitis viniferae, Jojoba oil, plant sterol
Ester, cetearyl alcohol, ceramide, vitamin E, green tea extract, water, glycerol, methyl propanediol, hyaluronate sodium, close sieve
Wood extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract, amino acid humectant, acetyl group tetrapeptide-5, solvable
Property proteoglycan and nanometer silver.
Steroid-dependent dermatitis repair cream the most according to claim 7, it is characterised in that in terms of weight/mass percentage composition, institute
State steroid-dependent dermatitis repair cream to include: hydrolecithin 1%～3%, distearyl acid polyglycerin ester-10 0.3%～
0.5%, behenyl alcohol 0.5%～1%, Oleum Vitis viniferae 4%～8%, Jojoba oil 4%～8%, plant sterol ester 1%～5%,
Cetearyl alcohol 0.2%～3%, ceramide 0.02%～0.5%, vitamin E 0.2%～1%, green tea extract 0.1%
～0.5%, acetyl group tetrapeptide-5 0.8%～2%, soluble protein polysaccharide 1%～2%, glycerol 4%～10%, methyl-prop two
Alcohol 1%～5%, hyaluronate sodium 0.1%～1%, amino acid humectant 1%～2%, close Luo Mu extract 0.5%～2%,
Burdock extract 0.5%～1.5%, Herba portulacae extract 0.5%～1.5%, Flos Lonicerae extract 0.5%～1.5%, nanometer
Silver 0.2%～1%, water is supplied.
9. the preparation method of steroid-dependent dermatitis repair cream as claimed in claim 5, it is characterised in that by emulsifying agent, plant
Oils and fats, horny layer renovation agent, cell nutrient solution, wetting agent, nanometer silver, close Luo Mu extract, burdock extract, Herba Portulacae are extracted
Thing, Flos Lonicerae extract mix with solvent, obtain steroid-dependent dermatitis repair cream.
10. preparation method as claimed in claim 9, it is characterised in that described emulsifying agent is that hydrolecithin, distearyl acid gather
Glyceride-10 and behenyl alcohol, described Vegetable oil lipoprotein is Oleum Vitis viniferae and Jojoba oil, and described horny layer renovation agent is plant sterol
Ester, cetearyl alcohol, ceramide, vitamin E and green tea extract, described cell nutrient solution is acetyl group tetrapeptide-5 and solvable
Property proteoglycan, described wetting agent is glycerol, methyl propanediol, hyaluronate sodium and amino acid humectant, and described solvent is water；
Its preparation method particularly as follows:
1) hydrolecithin, distearyl acid polyglycerin ester-10, behenyl alcohol, Oleum Vitis viniferae, Jojoba oil, plant sterol ester, spermaceti
Stearyl alcohol, ceramide, vitamin E are mixed and heated to 80 DEG C, obtain oil phase；
2) water, glycerol, methyl propanediol, hyaluronate sodium being mixed and heated to 85 DEG C, homogenizing, dispersed with stirring is uniform, obtains water
Phase；
3) oil phase is mixed with water, homogenizing, continuously stirred cooling；
4) close Luo Mu extract, burdock extract, Herba portulacae extract, Flos Lonicerae extract, green is added after being cooled to 45 DEG C
Tea extract, amino acid humectant, acetyl group tetrapeptide-5, soluble protein polysaccharide, nanometer silver stir, and filter.
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