CN105267261A - Plant extract combination having skin repair promoting and healing promoting function - Google Patents
Plant extract combination having skin repair promoting and healing promoting function Download PDFInfo
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- CN105267261A CN105267261A CN201410356617.7A CN201410356617A CN105267261A CN 105267261 A CN105267261 A CN 105267261A CN 201410356617 A CN201410356617 A CN 201410356617A CN 105267261 A CN105267261 A CN 105267261A
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Abstract
The present invention discloses a plant extract combination, which comprises centella asiatica total glycosides, tremella polysaccharides and bletilla striata polysaccharides, wherein preferably a weight ratio of the centella asiatica total glycosides to the tremella polysaccharides to the bletilla striata polysaccharides is 8.3%:83.4%:8.3%. According to the present invention, the plant extraction composition can be prepared into the appropriate drugs or cosmetics for prevention or treatment of skin injury symptoms, and the total content of the plant extract composition adopted as the active ingredient in the final product is 0.5-30%; and the extract composition can for the synergy effect, has effects of damaged skin repair from many ways, skin healing promoting and effective scarring reducing, and has the effect superior to the single extract component having the same dose.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of plant extract combination with promotion skin repair and healing function.
Background technology
In daily life, by many factors impact (as extraneous physical chemical factor, autologous hormones level change, mechanical pressure, Neuropsychical facto), cause normal skin to occur dysfunction, skin collagen textural anomaly, becomes fragile, and occurs relevant skin damage problem.First degree wound is only limitted to skin epidermis; Slightly severe one has skin and subcutaneous tissue fracture, and occurs wound; Serious wound can muscle injury, flesh key.The former heals by epithelium regeneration, and because wound is serious both rear, skin self cannot often need manual intervention to treat by healing.After tendon rupture, the initial stage is also scar repairing, but constantly reconstructs along with functional exercise, and collagen fiber by original tendon machine direction arrangement, can reach holomorphosis.Striae atrophicae produces due to the rapid and unexpected tractive of skin, is more similar to tearing of skin.Therefore, the target cell of striae atrophicae injury is fibroblast.Fibroblast there occurs phenotypic alternation when being transformed into myofibroblasts by mechanical swelling, and hormonal readiness changes its metaboilic level.In addition, this process is also along with the generation of inflammatory conditions.Therefore, striae gravidarum (or claiming striae atrophicae) main risk factor is mechanical stretching, hormone and inflammation.
From Chinese Chinese Traditional Medicine document is recorded, the plant that comprehensively can promote skin repair and wound healing can be inquired.As:
Herba Centellae (CentellaasiaticaL.Urban.) is also known as collapsing jorum, Herba sambuci chinensis, Herba Glechomae, Herba Christiae Obcordatae etc., for Umbelliferae Centella plant, be distributed widely in various places on the south the Yangtze river basin, be that Chinese herbal medicine is commonly used in area among the people, Guangdong, China is medically by Herba Centellae external and existing more than 2,000 years history of curing the disease for oral administration.Be the conventional Chinese medicine that " Chinese Pharmacopoeia " records, begin to be loaded in Shennong's Herbal, be classified as middle product, there is effect of clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, be used for clinically treating traumatic injury, dermatosis etc.
The Pseudobulbus Bletillae (Rhizoma Bletillae) is the dry tuber of orchid Pseudobulbus Bletillae (Rhizoma Bletillae) Bletillastriata (Thunb) Reichb.f., another name Rhizoma Alpiniae Officinarum, Rhizoma Bletillae.Li Shizhen (1518-1593 A.D.) releases its day: its root white, connect and and give birth to, therefore day the Pseudobulbus Bletillae (Rhizoma Bletillae).Just on the books as far back as Shennong's Herbal, within 1963, become one of kind that each version pharmacopeia records later.Its bitter in the mouth, sweet, puckery, property is put down cooler, returns lung, stomach, Liver Channel.The Pseudobulbus Bletillae (Rhizoma Bletillae) has tonifying the lung, hemostasis, detumescence, granulation promoting, sore.Pseudobulbus Bletillae (Rhizoma Bletillae) function cures mainly lung and hinders hemoptysis, epistaxis, and incised wound is hemorrhage, swollen ulcer drug, canker sores, and boiling hot fire is burnt, rhagadia manus et pedis, anal fissure and nipple Fissure etc.Therefore the title of " must be puckery and receive, enter lung hemostasis, granulation promoting controls skin ulcer, and surgery is kind " is have.
Tremella tremella, is born in temperate zone and subtropical zone, is a sporophore for basidiomycetes subclass Tremellaceae Tremella (TremellafuciformisBerk), also known as Tremella.As a kind of edible fungi and important medical material of preciousness, Tremella is put down sweet nontoxic, YIN nourishing, lung moistening, nourishing the stomach, promotes the production of body fluid, the diseases such as treatment cough due to lung-heat, gastritis, stool hematochezia, dysentery, facial speckle, cancer.
Modern Chinese medicine extraction separation means, for formulating provides the research method of standardization and quantification.
Pharmacologically active and its chemical composition of Herba Centellae are closely related, and chemical composition known at present mainly contains triterpenes, flavonoid, polyacetylene alkene class, volatile oil.Triterpenes is studied the earliest, mainly contains triterpene saponin (as Herba Centellae total glycosides, madacasso grass total glycosides, Bo Re meter glycosides, joining bitter Buddhist nun's glycosides etc.).According to now there are some researches show, Herba Centellae total glycosides has following effect: the fibroblast of employment carries out In vitro culture, add certain density asiatic centella triterpenoid extract, the synthesis of collagen protein and fibronectin can be made obviously to increase, and stimulate the biosynthesis of proline, chondroitin sulfate and Heparan sulfate, there is the effect promoting wound healing.The monarchs that show one's high ideals etc., by the swollen experiment of rat granuloma and the experiment of mice caused by dimethylbenzene xylene ear swelling, find that Herba Centellae total glycosides has certain inhibitory action to swelling, show that total Of Triterpenes has obvious antiinflammatory action to skin.A large amount of clinical verification is also passed through in the safety of Herba Centellae total glycosides, is a composition that can use safely.
The main chemical compositions of the Pseudobulbus Bletillae (Rhizoma Bletillae) is polysaccharide, bibenzyl (bibenzyls) and luxuriant and rich with fragrance class (phenanthrenes) and derivant thereof.Studying many is Pseudobulbus Bletillae polysaccharose.Pseudobulbus Bletillae polysaccharose can form protecting film at wound, and has antibacterial, to stimulate granulation tissue growth effect, is conducive to wound healing, improves wound healing quality.In vitro culture result of the test shows, the expression of Pseudobulbus Bletillae polysaccharose to rat dermal fibroblasts has obvious facilitation, and its action intensity is relevant with drug level.In rat back incision wound surface recovery process, Pseudobulbus Bletillae polysaccharose improves the level of wound surface hydroxyproline content and extracellular matrix collagen; Promote the hypertrophy of fibroblast and vascular endothelial cell.Please and studied the toxicity of Pseudobulbus Bletillae polysaccharose in great detail with scholar etc.By intravenous injection, lumbar injection and gavage three kinds of approach, use Pseudobulbus Bletillae polysaccharose to Kun Ming mice.Result shows the LD of mouse tail vein injection
50for 595mg/kg, the LD of lumbar injection
50for 804mg/kg, the minimum lethal dose >2000mg/kg of gavage.Carry out local toxicity test with it domesticated dog, Pseudobulbus Bletillae polysaccharose without obvious irritation to liver, brain, subcutaneous tissue etc., does not bring out infective inflammation, does not affect wound healing, and tissue resorption is very fast, is beneficial to wound healing.The dermatoxicology safety research to Pseudobulbus Bletillae polysaccharose such as Zhang Weiming also shows, Pseudobulbus Bletillae polysaccharose is non-stimulated to skin, and ametabolism reaction and phototoxic reaction, to human body skin without obvious adverse reaction.Zhang Weiming etc. carry out dermatoxicology safety testing to bletilla striata polyoses glue: acute toxicity test in mice, skin repeatedly irritant test, skin allergic reaction, the test of skin light poison, people show consideration for patch test, result shows, Pseudobulbus Bletillae polysaccharose is non-stimulated to skin, ametabolism reaction and phototoxic reaction, do not cause obvious untoward reaction to human body skin yet.The human skin fibroblast of bletilla striata extract to In vitro culture has obvious growth promoting effects effect, and its effect is better than AHA, has anti-aging effects to human fibroblasts simultaneously, can the process of delaying cell aging.
Containing abundant tremella polysaccharide (accounting for the 60%-70% of Tremella dry weight) in Tremella, polysaccharide body contained by Tremella is acid different polysaccharide, its main component is except 1,3 or 1, outside 6 glucosans, still there are xylose, glucuronic acid and mannose (115:1:317), also have a small amount of glucose and micro-fucose.As the tremella polysaccharide of natural active matter, research in recent years oneself fully confirm that it is the principle active component of Tremella, its health-care effect is as follows: the immunologic function of (1) obvious enhancing body, promotes Hepatocyte Glycogen synthesis and antitumor, mutation, radioprotective and leukocyte increasing; (2) antioxidation, can scavenging free radicals to the destruction of body, anti-senility, life lengthening; (3) obviously can alleviate the degree of the rat paw edema caused by formaldehyde, show its to inflammation ooze out and edema has obvious resistant function; Obviously can suppress the formation of stress in rats type ulcer, promote the healing of ulcer, have anti-inflammation detumescence, promote the effect of ulcer healing; (4) tremella polysaccharide is by affecting intrinsic coagulation system, prolongation thrombin time and realize blood coagulation resisting function.In addition, tremella polysaccharide has protection wound surface, prevention infection effect to tested rat wound, wound can be made to repair approach along physiology and carry out smoothly, thus reach the effect that the I phase heals.About the research of tremella polysaccharide toxicity, side effect also has report: Jia Hanqing etc. report that tremella polysaccharide is to all free of toxic effects such as central nervous system, respiratory system, blood system and the heart, liver, kidney etc., does not affect the reproductive performance of mice and the survival rate of young baby.Tremella polysaccharide also can not cause acute and chronic poisoning, without three-induced effect, belongs to non-toxic substance.
Because this several extract is all be derived from domestic frequently seen plants, wide material sources, be easy to obtain.Experiment proves, several component is under certain conditions of mixture ratios, obviously can be enhanced to fibrocellular propagation, strengthen the regulatory function of skin collagen, increase the quantity of skin collagen protein, improve the function of collagen protein, reduce inflammation reaction, promotes the healing of damaged skin, and these three kinds of active ingredient combination application make effect of each component produce synergism, play the object of prevention or the relevant skin problem for the treatment of.
As above several plant extract respectively has the effect promoting wound healing, and mechanism is respectively not quite similar, and physical property is also had nothing in common with each other, as bad in Herba Centellae total glycosides water solublity, and Pseudobulbus Bletillae polysaccharose, tremella polysaccharide can form colloidal solution, its application in the product can be affected.Meanwhile, due to extract price costly, be used alone a kind of extract and will reach and promote that the Financial cost of wound healing is higher.
Summary of the invention
The object of the invention is to overcome above-mentioned deficiency, there is provided a kind of for prevention or promote skin repair and healing function effect high, using dosage is low, the composition of plant extracts of the more natural Herba Centellae total glycosides of skin colour of healing place, tremella polysaccharide and Pseudobulbus Bletillae polysaccharose.
Another object of the present invention is that this using dosage is low, to the application of the strong composition of plant extracts of whitening moisturizing effect, as the external preparation for skin product that is active ingredient with the compositions of Herba Centellae total glycosides, tremella polysaccharide, Pseudobulbus Bletillae polysaccharose three kinds of compositions or three kinds of extracts and preparation method thereof.
In said composition of the present invention, the content part by weight of Herba Centellae total glycosides, tremella polysaccharide and Pseudobulbus Bletillae polysaccharose is 5% ~ 30%:20% ~ 90%:5% ~ 30%; More excellent weight ratio is 7% ~ 17%: 35%-85%: 7% ~ 17%, and more preferably part by weight is 8.3%: 83.4%: 8.3%, and above composition of plant extracts is defined as Lestr í x by us.
Wherein hydroxyl asiaticoside and asiaticoside in Herba Centellae total glycosides, and the two weight total amount accounts for Herba Centellae total glycosides more than 55%.
Above-mentioned composition of plant extracts is for the preparation of prevention or promote skin repair and the heal medicine of function or the purposes of cosmetics, and product form comprises gel, cream frost, serosity, water preparation, emulsion or solid form.
The product preparation method of above-mentioned form is, each to Herba Centellae total glycosides, tremella polysaccharide and Pseudobulbus Bletillae polysaccharose compositions is proportionally added in high-speed solid mixer successively, whipping temp 10 ~ 65 DEG C, mixing time 30 ~ 120 minutes, the powdery product of Homogeneous phase mixing, or by above-mentioned plant extract and medically acceptable inert matter or carrier proportionally Homogeneous phase mixing.
Above-mentioned medicine or cosmetics for preventing or promote skin repair and healing function, the composition of plant extracts total content in the final product wherein as active component is 0.5%wt ~ 30%wt.
Above-mentioned for prevention or promote skin repair and healing function medicament or cosmetics, composition of plant extracts total content in the final product wherein as active component is 10%wt ~ 20%wt, and the preferred composition of plant extracts as active component total content is in the final product 12%wt.
The invention still further relates to above-mentioned for preventing or promoting that the external preparation for skin product of skin repair and healing function is medicine or cosmetics.
The present invention, for preventing or promoting that the external preparation for skin product of skin repair and healing function is medicine or cosmetics, has obvious preventive effect to striae gravidarum, even and if have its extent of damage of striae gravidarum also lighter.Embodiment result shows: Primiparous time-pregnant women 20 in test, is divided into 2 groups at random, wherein smears the women containing Lestr í x moisturizer, does not produce 7 examples of striae gravidarum, has 2 examples of slight striae gravidarum, has only 1 example of serious striae gravidarum.And only use in pregnant woman 10 example of blank moisturizer, only have 3 examples not have striae gravidarum, 4 examples have slight striae gravidarum, and 3 examples have serious striae gravidarum.Secondly, to giving birth to and having striae gravidarum women, the color of striae gravidarum obviously can be made thin out, and increase skin firmness, beautify damaged skin.Educated and had the women of striae gravidarum for 6 in test, 3 use the women containing Lestr í x moisturizer as requested, and the color of its striae gravidarum is thin out and close with normal skin tone, and skin is consolidation comparatively.And other 3 use the forepart pregnant women stricture of vagina color of blank moisturizer only slightly thin out, skin is more lax.
Of the present invention containing above-mentioned composition of plant extracts for preventing or promoting that the medicine that the plant extract of skin repair and healing function combines or cosmetics transdermal stimulation test (repeatedly) and Skin allergy test, test result is respectively: skin irritation strength grading belongs to nonirritant; By sensitization strength grading standard, be judged to and have no skin allergic reaction.
The present invention is for preventing or promoting that the plant extract of skin repair and healing function combines, the use in conjunction of three kinds of active component makes each component effect produce synergism, thus the function of wound healing is enhanced to make said composition promote, the object promoting wound healing is reached with low dosage, and prevent pruritus and allergy in wound, and the generation of cicatrix.
The present invention not only can compared with producing good prevention during low dosage or promoting skin repair and healing function, and not have allergic stimulated symptom to produce during continuous life-time service.Repairing damaged skin from many aspects, by promoting fibroblastic propagation, making the hypodermal cell of reparation restart the metabolism of damaged zone cell and the synthesis of collagen and elastin laminin; By suppressing the content of interleukin in keratinocyte, reducing skin damage place inflammatory cell infiltration, promote skin healing, and effectively can reduce cicatrization; Result of use of the present invention is better than the result of use of the independent a kind of extract component of same dose.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with detailed description of the invention, the present invention is described in more detail.Should be appreciated that, these describe just exemplary, and do not really want to limit the scope of the invention.In addition, in the following description, the description to known features and technology is eliminated, to avoid unnecessarily obscuring concept of the present invention.
Embodiment 1 plant extract of the present invention is for the preparation of prevention or promote skin repair and the preparation method of the emulsion of the function that heals
Preparation method comprises the following steps:
1. production equipment used is cleaned up, disinfect, stand-by.
2. it is 100 parts in all the components, water (47.81 parts), glycerol (5), butanediol (5), xanthan gum (0.35), carbomer (0.3) are added in ingredients pot, homogenizing makes xanthan gum, carbomer completely scattered, be heated to 80 ~ 85 DEG C, speed of agitator 35r/min, be incubated 30 minutes, dissolve good every.
3. Parleam (4), Fructus oleae europaeae (OLEAEUROPAEA) fruit oil (3), Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit fat (3), cetearyl alcohol (2), Coco-Glucoside (2), PEG-20 stearate (1.5), glyceryl stearate (1.5), PEG-100 stearate (1.25), caprylic/capric triglyceride (1), tocopherol (vitamin E) (0.95), polydimethylsiloxane (0.9) are added oil phase pot successively, heat 80 ~ 85 DEG C, stir insulation 30 minutes, speed of agitator 25r/min.
4. open cooling water temperature to 60 DEG C and add Jojoba esters (0.82), speed of agitator 42r/min, stir 10 minutes.
5. be cooled to 42 DEG C and add Tremella (TREMELLAFUCIFORMIS) polysaccharide (10), Pseudobulbus Bletillae polysaccharose (1), methyl-monosilane alcohol hydroxyproline ester aspartate (6), Herba Centellae total glycosides (1), elastin laminin (1), Sensiva SC50 (0.32), caprylyl glycol (0.1), phenylpropanol (0.1), 1 successively, ammediol (0.1), open and stir, mixing speed 30r/min, stirs 10 minutes.
6. being cooled to 38 DEG C of samplings send laboratory to detect, qualified rear filtration discharging, leaves standstill.
Embodiment 2 plant extract of the present invention is for the preparation of prevention or promote skin repair and the preparation method of the cream frost of the function that heals
Preparation method comprises the following steps:
1. production equipment used is cleaned up, disinfect, stand-by.
2. be 100 parts in all the components, butanediol (22) and portions of de-ionized water (30) dissolved tremella polysaccharide (3.7), Pseudobulbus Bletillae polysaccharose (0.5), Herba Centellae total glycosides (0.8), filters stand-by.
3. by white oil (8), Parleam (4), cetearyl alcohol (2), Coco-Glucoside (2), PEG-20 stearate (1.5), glyceryl stearate (1.5), PEG-100 stearate (1.25), caprylic/capric triglyceride (1), tocopherol (0.95), polydimethylsiloxane (0.9) are added oil phase pot successively, heat 80 ~ 85 DEG C, stir insulation 30 minutes, speed of agitator 25r/min.
4. be cooled to 42 DEG C and add residue deionized water (12.28), methyl-monosilane alcohol hydroxyproline ester aspartate (6), elastin laminin (1), Sensiva SC50 (0.32), caprylyl glycol (0.1), phenylpropanol (0.1), 1 successively, ammediol (0.1), open and stir, mixing speed 30r/min, stir 10 minutes, add Herba Centellae total glycosides, tremella polysaccharide, the bletilla striata extract of having filtered, stir evenly, be cooled to room temperature.
5. being cooled to 38 DEG C of samplings send laboratory to detect, qualified rear filtration discharging, leaves standstill.
Embodiment 3 plant extract of the present invention is for the preparation of prevention or promote skin repair and the preparation method of the emulsion of the function that heals
Preparation method comprises the following steps:
1. production equipment used is cleaned up, disinfect, stand-by.
2. it is 100 parts in all the components, water (59.31 parts), glycerol (5), butanediol (5), xanthan gum (0.35), carbomer (0.3) are added in ingredients pot, homogenizing makes xanthan gum, carbomer completely scattered, be heated to 80 ~ 85 DEG C, speed of agitator 35r/min, be incubated 30 minutes, dissolve good every.
3. Parleam (4), Fructus oleae europaeae (OLEAEUROPAEA) fruit oil (3), Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit fat (3), cetearyl alcohol (2), Coco-Glucoside (2), PEG-20 stearate (1.5), glyceryl stearate (1.5), PEG-100 stearate (1.25), caprylic/capric triglyceride (1), tocopherol (vitamin E) (0.95), polydimethylsiloxane (0.9) are added oil phase pot successively, heat 80 ~ 85 DEG C, stir insulation 30 minutes, speed of agitator 25r/min.
4. open cooling water temperature to 60 DEG C and add Jojoba esters (0.82), speed of agitator 42r/min, stir 10 minutes.
5. be cooled to 42 DEG C and add tremella polysaccharide (0.4), Pseudobulbus Bletillae polysaccharose (0.05), methyl-monosilane alcohol hydroxyproline ester aspartate (6), Herba Centellae total glycosides (0.05), elastin laminin (1), Sensiva SC50 (0.32), caprylyl glycol (0.1), phenylpropanol (0.1), 1 successively, ammediol (0.1), open and stir, mixing speed 30r/min, stirs 10 minutes.
6. being cooled to 38 DEG C of samplings send laboratory to detect, qualified rear filtration discharging, leaves standstill.
Embodiment 4 plant extract of the present invention is for the preparation of prevention or promote skin repair and the preparation method of the microemulsion of the function that heals
Preparation method comprises the following steps:
1. by deionized water (44.6), 1,3 butylene glycol (7), Herba Centellae total glycosides (3), tremella polysaccharide (4), Pseudobulbus Bletillae polysaccharose (3), methyl hydroxybenzoate (0.2), PEG1500(5), glycerol (10), Carbomer981 (0.15) mix homogeneously 50 ~ 60 DEG C time.
2. by glycerol, 1,3-butanediol, Cremophor RH40, PEG-50 castor oil hydrogenated, PEG-60 castor oil hydrogenated, Parleam, spermol ethylhexoate, phenyl phenol, deionized water add under agitation respectively, and mix homogeneously (all components accounts for 15% altogether).
3. under agitation by component mix homogeneously prepared by 1 and 2 steps.
4. will synthesize squalane (8) under agitation, KOH water (0.05) will slowly add in 3.
Embodiment 5 plant extract of the present invention is for the preparation of prevention or promote skin repair and the preparation method of the emulsion of the function that heals
Preparation method comprises the following steps:
1. production equipment used is cleaned up, disinfect, stand-by.
2. it is 100 parts in all the components, water (39.81 parts), glycerol (5), butanediol (5), xanthan gum (0.35), carbomer (0.3) are added in ingredients pot, homogenizing makes xanthan gum, carbomer completely scattered, be heated to 80 ~ 85 DEG C, speed of agitator 35r/min, be incubated 30 minutes, dissolve good every.
3. Parleam (4), Fructus oleae europaeae (OLEAEUROPAEA) fruit oil (3), Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit fat (3), cetearyl alcohol (2), Coco-Glucoside (2), PEG-20 stearate (1.5), glyceryl stearate (1.5), PEG-100 stearate (1.25), caprylic/capric triglyceride (1), tocopherol (vitamin E) (0.95), polydimethylsiloxane (0.9) are added oil phase pot successively, heat 80 ~ 85 DEG C, stir insulation 30 minutes, speed of agitator 25r/min.
4. open cooling water temperature to 60 DEG C and add Jojoba esters (0.82), speed of agitator 42r/min, stir 10 minutes.
5. be cooled to 42 DEG C and add tremella polysaccharide (17), Pseudobulbus Bletillae polysaccharose (1), methyl-monosilane alcohol hydroxyproline ester aspartate (6), Herba Centellae total glycosides (2), elastin laminin (1), Sensiva SC50 (0.32), caprylyl glycol (0.1), phenylpropanol (0.1), 1 successively, ammediol (0.1), open and stir, mixing speed 30r/min, stirs 10 minutes.
6. being cooled to 38 DEG C of samplings send laboratory to detect, qualified rear filtration discharging, leaves standstill.
Embodiment 6 plant extract of the present invention is for the preparation of prevention or promote skin repair and the preparation method of the emulsion of the function that heals
Preparation method comprises the following steps:
1. production equipment used is cleaned up, disinfect, stand-by.
2. it is 100 parts in all the components, water (34.81 parts), glycerol (5), butanediol (5), xanthan gum (0.35), carbomer (0.3) are added in ingredients pot, homogenizing makes xanthan gum, carbomer completely scattered, be heated to 80 ~ 85 DEG C, speed of agitator 35r/min, be incubated 30 minutes, dissolve good every.
3. Parleam (4), Fructus oleae europaeae (OLEAEUROPAEA) fruit oil (3), Butyrospermum parkii (BUTYROSPERMUMPARKII) fruit fat (3), cetearyl alcohol (2), Coco-Glucoside (2), PEG-20 stearate (1.5), glyceryl stearate (1.5), PEG-100 stearate (1.25), caprylic/capric triglyceride (1), tocopherol (vitamin E) (0.95), polydimethylsiloxane (0.9) are added oil phase pot successively, heat 80 ~ 85 DEG C, stir guarantor 30 minutes, speed of agitator 25r/min.
4. open cooling water temperature to 60 DEG C and add Jojoba esters (0.82), speed of agitator 42r/min, stir 10 minutes.
5. be cooled to 42 DEG C and add tremella polysaccharide (14), Pseudobulbus Bletillae polysaccharose (5), methyl-monosilane alcohol hydroxyproline ester aspartate (6), Herba Centellae total glycosides (6), elastin laminin (1), Sensiva SC50 (0.32), caprylyl glycol (0.1), phenylpropanol (0.1), 1 successively, ammediol (0.1), open and stir, mixing speed 30r/min, stirs 10 minutes.
6. being cooled to 38 DEG C of samplings send laboratory to detect, qualified rear filtration discharging, leaves standstill.
Embodiment 7 plant extract of the present invention is for the preparation of prevention or promote skin repair and the heal medicine of function or the clinical observation of cosmetics.
Test crowd: Primiparous time-pregnant women 20 (during on-test pregnant all <12 weeks), has given birth to and has had striae gravidarum women 6.
Test method: Primiparous time-pregnant women is divided into 2 groups at random, A group and B group, often organize 10 people, namely uses containing Lestr í x test moisturizer and use blank moisturizer group.Give birth to and had striae gravidarum women stochastic averagina to assign to A, B two groups.
Smear mode: Primiparous time-pregnant women was from pregnant 12 weeks, and every day is applied in abdominal part, until childbirth.Educate women to smear every day, 4 totally months.
Result of the test: in table 1, table 2.Result shows: testing moisturizer preparation containing Lestr í x has obvious preventive effect to the striae gravidarum that pregnant woman may occur, even and if have its extent of damage of striae gravidarum also lighter.Secondly, to giving birth to and having striae gravidarum women, test moisturizer containing Lestr í x and can obviously make the color of striae gravidarum thin out, and increase skin firmness, beautify damaged skin.
Table 1 Primiparous time-pregnant women application tests moisturizer preparation to the preventive effect of striae gravidarum containing Lestr í x
Table 2 has been educated and has been had striae gravidarum women to apply and tested moisturizer preparation to the restitution of striae gravidarum containing Lestr í x
| Educate and had striae gravidarum women | Striae gravidarum color | Skin firmness |
| Moisturizer (A group) is tested containing Lestr í x | Striae gravidarum is thin out and close with normal skin tone | Comparatively consolidation |
| Blank moisturizer (B group) | Striae gravidarum is thin out | More lax |
Both each component of composition of plant extracts of the present invention first can be prepared in the present invention, then composition of plant extracts of the present invention is prepared thus, further preparation contains medicine or the cosmetics for preventing or promote skin repair and healing function of above-mentioned composition, also each compositions of composition of plant extracts of the present invention can first be prepared, then directly preparation contains medicine or the cosmetics for preventing or promote skin repair and healing function of above-mentioned composition thus, and does not need the step of independent preparation composition of plant extracts of the present invention.It will be understood by those skilled in the art that above-mentioned two kinds of methods are equivalent with regard to final products.
Although describe embodiments of the present invention in detail, it should be understood that when without departing from the spirit and scope of the present invention, various change, replacement and change can be made to embodiments of the present invention.
Claims (9)
1. a plant extract compositions, is characterized in that said composition is made up of Herba Centellae total glycosides, tremella polysaccharide, Pseudobulbus Bletillae polysaccharose.
2. plant extract compositions according to claim 1, is characterized in that the content part by weight of Herba Centellae total glycosides, tremella polysaccharide and Pseudobulbus Bletillae polysaccharose is Herba Centellae total glycosides: 5%-30%, tremella polysaccharide: 20%-90%, Pseudobulbus Bletillae polysaccharose: 5%-30%.
3. plant extract compositions according to claim 1, is characterized in that the content part by weight of Herba Centellae total glycosides, tremella polysaccharide and Pseudobulbus Bletillae polysaccharose is Herba Centellae total glycosides: 7%-17%, tremella polysaccharide: 35%-85%, Pseudobulbus Bletillae polysaccharose: 7%-17%.
4. plant extract compositions according to claim 1, is characterized in that the content part by weight of Herba Centellae total glycosides, tremella polysaccharide and Pseudobulbus Bletillae polysaccharose is 8.3%: 83.4%: 8.3%.
5. the composition of plant extracts according to any one of Claims 1-4 is for preventing or promote the externally applied product preparation method of skin repair and healing function, it is characterized in that: by each component of above-mentioned composition of plant extracts or above-mentioned composition of plant extracts and medically acceptable inert matter or carrier mixing, acquisition form is the goods of gel, cream frost, serosity, water preparation, emulsion or solid.
6. composition of plant extracts according to claim 5 is for preventing or promote the preparation method of externally applied product of skin repair and healing function, it is characterized in that: by each component of above-mentioned composition of plant extracts or above-mentioned composition of plant extracts and medically acceptable inert matter or carrier mixing, acquisition form is the goods of gel, cream frost, serosity, water preparation, emulsion or solid.
7. according to claim 6 for preventing or promote medicine or the cosmetics of skin repair and healing function, it is characterized in that being wherein 0.5%wt ~ 30%wt as the composition of plant extracts total content in the final product of active component.
8. according to claim 7 for preventing or promote medicine or the cosmetics of skin repair and healing function, it is characterized in that wherein being respectively 10%wt ~ 20%wt as the composition of plant extracts content in the final product of active component.
9. according to claim 8 for preventing or promote medicine or the cosmetics of skin repair and healing function, it is characterized in that being wherein 12%wt as the composition of plant extracts total content in the final product of active component.
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| CN201410356617.7A CN105267261A (en) | 2014-07-25 | 2014-07-25 | Plant extract combination having skin repair promoting and healing promoting function |
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| CN201410356617.7A CN105267261A (en) | 2014-07-25 | 2014-07-25 | Plant extract combination having skin repair promoting and healing promoting function |
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| CN105267261A true CN105267261A (en) | 2016-01-27 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109044964A (en) * | 2018-10-16 | 2018-12-21 | 长江师范学院 | A kind of edible fungi polysaccharide gelling agent and its preparation method and application |
| CN109820842A (en) * | 2018-11-20 | 2019-05-31 | 中国科学院昆明植物研究所 | Batatasins III are preparing the application in drug and cosmetics |
| CN115054559A (en) * | 2022-06-27 | 2022-09-16 | 辽宁咏梅生物科技有限公司 | Preparation method of skin repair solution for relieving strange marks of mask |
| WO2024067330A1 (en) * | 2022-09-30 | 2024-04-04 | 浙江普利药业有限公司 | Use of pentacyclic triterpenoid compound in preparing medicament for preventing and/or treating sarcoidosis |
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| CN103655355A (en) * | 2013-12-19 | 2014-03-26 | 栾晓健 | Lotion capable of removing stretch marks |
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| CN103655355A (en) * | 2013-12-19 | 2014-03-26 | 栾晓健 | Lotion capable of removing stretch marks |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109044964A (en) * | 2018-10-16 | 2018-12-21 | 长江师范学院 | A kind of edible fungi polysaccharide gelling agent and its preparation method and application |
| CN109820842A (en) * | 2018-11-20 | 2019-05-31 | 中国科学院昆明植物研究所 | Batatasins III are preparing the application in drug and cosmetics |
| CN115054559A (en) * | 2022-06-27 | 2022-09-16 | 辽宁咏梅生物科技有限公司 | Preparation method of skin repair solution for relieving strange marks of mask |
| WO2024067330A1 (en) * | 2022-09-30 | 2024-04-04 | 浙江普利药业有限公司 | Use of pentacyclic triterpenoid compound in preparing medicament for preventing and/or treating sarcoidosis |
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