CN109044964A - A kind of edible fungi polysaccharide gelling agent and its preparation method and application - Google Patents
A kind of edible fungi polysaccharide gelling agent and its preparation method and application Download PDFInfo
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- CN109044964A CN109044964A CN201811203189.9A CN201811203189A CN109044964A CN 109044964 A CN109044964 A CN 109044964A CN 201811203189 A CN201811203189 A CN 201811203189A CN 109044964 A CN109044964 A CN 109044964A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Abstract
The invention discloses a kind of edible fungi polysaccharide gelling agent and its preparation method and application, the component including following parts by weight: compounding 1~2 part of polysaccharide, 10~20 parts of glycerol, 0.1~0.2 part of carbomer, 0.1~0.2 part of EDTA-2Na, 100~200 parts of water.Edible fungi polysaccharide gelling agent prepared by the present invention is hormone-free, it is nontoxic to skin, mild non-stimulated, the gelling agent moisture retention prepared is good, stability is good, can promote the quick reparation of skin trauma, and raw material is simple and easy to get, it is at low cost, it is easy to operate, it is easy to use, it all has a good application prospect in medicine, cosmetics.
Description
Technical field
The present invention relates to Edible mushroom processing field, in particular to a kind of edible fungi polysaccharide gelling agent and preparation method thereof and
Using.
Background technique
The pharmaceutical preparation of current some home-use promotion wound healings mainly includes the ingredients such as antibiotic, these antibiotic
There are certain potential hazards, and antibiotic is commonly used, will cause bacteria resistant and induce novel bacterial.But antibiotic
Research and development progress far away from the Evolution Rates of new bacterium, be likely to cause bacterium infection in the future and available without medicine.In addition to this, existing
The pharmaceutical preparation of promotion wound healing do not have the defect of the substance that necessary nutrition is provided for Wound healing also.With people
The source of effective ingredient is increasingly paid attention in improvement of living standard, if from natural animal or the ingredient of plant, it is past
It is less side effects toward its, it will receive the welcome of users.
Edible fungi polysaccharide is main active constituent in edible mushroom, is referred to as known as " biological respinse modifier ", has life
Object reacts the feature of instrumentality, can be used as immunopotentiator and immunoactivator, while edible fungi polysaccharide has very high infiltration
Pressure, viscosity and water imbibition, and can be good at affinity with skin, it can be used as the use such as gelling agent, lubricant, flocculant, energy
It is enough in and prepares medical material, medicinal slow release agent and cosmetic additive agent etc..Tremella polysaccharides and lentinan have high protein, low
The feature of fat, not only mineral element rich in, but also essential amino acid and nonessential amino acid containing there are many.
Summary of the invention
In view of the above shortcomings of the prior art, the purpose of the present invention is to provide a kind of edible fungi polysaccharide gelling agent and its systems
Preparation Method and application solve the problems, such as that the existing drug side-effect for promoting wound healing is big and cannot provide wound nutriment.
In order to solve the above-mentioned technical problem, present invention employs the following technical solutions: a kind of edible fungi polysaccharide gelling agent,
Including following parts by weight component: compounding 1~2 part of polysaccharide, 10~20 parts of glycerol, 0.1~0.2 part of carbomer, EDTA-2Na
0.1~0.2 part, 100~200 parts of water；The compounding polysaccharide is the composition of tremella polysaccharides and lentinan.
Further, the mass ratio of lentinan and tremella polysaccharides is 1:0.5~2 in the compounding polysaccharide.
Further, the compounding polysaccharide is extracted using following methods:
Step 1: it will be ground into powder after tremella and mushroom drying, deionized water is then added, 2h is extracted in boiling water bath,
The first extracting solution and filter residue is obtained by filtration, deionized water is added into the filter residue, 2h is extracted in boiling water bath, is obtained by filtration
Two extracting solutions；The solid-to-liquid ratio of the powder and deionized water is 1g:(25~30) ml；
Step 2: the first extracting solution in step 1 and the second extracting solution being merged, and supernatant is collected by centrifugation, then by the supernatant
It is placed in rotary evaporator, is concentrated into the 1/4~1/5 of original volume in 90 DEG C and obtains concentrate；
Step 3: dehydrated alcohol will be added in concentrate that step 2 obtains, sediment is collected after centrifugation in 4 DEG C of precipitating 12h,
Then the sediment is dried in vacuo to get crude extract is arrived；
Step 4: the crude extract that step 3 is obtained is dissolved in deionized water, with the albumen in Sevag method removal solution
Matter, then 95% ethyl alcohol is added into the solution for go isolating protein, it quickly stirs, makes polysaccharide homogeneous precipitation, overnight, it is heavy to be collected by centrifugation
It forms sediment, the precipitating is dried in vacuo to obtain compounding polysaccharide.
The preparation method of the edible fungi polysaccharide gelling agent, comprising the following steps:
1) EDTA-2Na is dissolved in distilled water, is added with stirring carbomer, and accelerate swelling to be blocked in 60 DEG C of water-baths
Wave nurse glue；
2) it is soluble in water that polysaccharide will be compounded, glycerol is added, obtain polysaccharide solution after mixing evenly；
3) polysaccharide solution made from carbomer glue made from step 1) and step 2 is uniformly mixed to get edible mushroom is arrived
Polysaccharide gel.
Further, the concentration that polysaccharide is compounded in the edible fungi polysaccharide gelling agent is 0.006~0.012g/ml.
The edible fungi polysaccharide gelling agent is promoting the application in wound healing.
Mushroom: the title of civil " mountain delicacy ", sweet, flat, nontoxic, big benefit stomach Qi is rich in lentinan, a variety of amino acid, micro
Element, micro-element, the active constituent in lentinan are β-(the 1-3)-D- glucans with branch, main chain by β-(1-3)-even
The glucosyl group composition connect, the glucosyl group connected along main chain random distribution by β-(1-6) are in pectinate texture.Lentinan
Have the effects that antiviral and antitumor, adjust immune function and stimulation interferon formation.
Tremella: having a laudatory title of " hat in bacterium ", and tremella polysaccharides are a kind of acid heteroglycans, backbone structure be by α-(1 →
3) mannosan of glucosides key connection, branch are made of glucuronic acid and xylose.Tremella polysaccharides have improvement immunity of organism function
The effect that can and promote leucocyte, is remarkably improved the phagocytic function of experimental animal reticuloendothelial cell, has promotion non-specific
Immunization improves the level of immunoglobulin, total complement of serum.
Compared with prior art, the invention has the following beneficial effects:
1, in edible fungi polysaccharide gelling agent prepared by the present invention include mannosan and beta glucan, content be up to 20% with
On, mannosan average molecular weight can reach 3,000,000 or more, no matter in low humidity or in high humility 85~1,300,000
Under the conditions of humectant all having the same further can improve skin electric conductivity integrated value, reduce water and discharge constant, improve
The barrier function of skin has the function of repairing epidermis, increases epidermis water content.Beta glucan can be with full activation human immunity
System, activated macrophage and neutrophil cell resist disease caused by microorganism, and excite the nospecific immunity of host
For the healing of tumour, infection disease and wound, the two is used in compounding to the work that can reach inhibiting bacteria and diminishing inflammation and accelerating wound healing
With.
2, it in polysaccharide gel prepared by the present invention, reticulates since compounding polysaccharide molecule chain is interweaved, contains on residue
There is a large amount of hydroxyl, by hydrogen bond, can combine and save many hydrones.One can be formed in skin surface by compounding polysaccharide simultaneously
The uniform film of layer reduces the moisture evaporation of skin surface.Therefore the high-hydroscopicity of compounding polysaccharide and good film forming are perfect
In conjunction with good moistening effect can be provided for skin.In addition ,-OH there are three containing in glycerol molecule, forms hydrogen bond with hydrone,
It can play the role of good moisture-absorbing moisture-keeping, the dissolubility of other components in gel can be increased.EDTA-2Na is complexing sustained release agent energy
The acid-base property of gel is adjusted, so each component synergistic effect improves the moisture retention of gelling agent in polysaccharide gel.
3, edible fungi polysaccharide gelling agent affinity prepared by the present invention is good, and penetration is strong, and the transparency and biocompatibility are high,
Hormone-free, nontoxic to skin, mild non-stimulated, without side-effects, moistening effect is good, has good stability, and raw material is simple and easy to get, at
This is low, easy to operate, easy to use, can promote the quick reparation of skin trauma, without side-effects.Importantly, this is edible
Rich in nutritional ingredients such as polysaccharide, a variety of amino acid, microelement and micro-elements in granulose gelling agent, can be provided for wound healing
Nutriment promotes the quick healing of wound.It all has a good application prospect in medicine, cosmetics.
Detailed description of the invention
Fig. 1 is to change over time wounds in mice healing variation photo.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail.
One, the extraction of polysaccharide is compounded
Step 1: tremella and mushroom fresh goods being cleaned and are cut into small pieces, 6h~8h is placed in drying box, with crushing after drying
Machine is ground into powder, by solid-liquid ratio 1:25 (g/mL) plus deionized water, 2h is then extracted in boiling water bath, first is obtained by filtration and mentions
Liquid and filter residue are taken, deionized water is added into the filter residue, 2h is then extracted in boiling water bath, the second extracting solution is obtained by filtration；
Step 2: the first extracting solution in step 1 and the second extracting solution being merged, in 4000r/min centrifugation 15min collection
Clearly, then by the supernatant it is placed in rotary evaporator, is concentrated into the 1/4~1/5 of original volume in 90 DEG C and obtains concentrate；
Step 3: dehydrated alcohol will be added in concentrate that step 2 obtains, sediment is collected after centrifugation in 4 DEG C of precipitating 12h,
Then the sediment is dried in vacuo to get crude extract is arrived；
Step 4: the crude extract that step 3 is obtained weighs 10g and is dissolved in 100ml deionized water, and the Sevag of 25ml is added
Reagent (chloroform: n-butanol=4:1) is placed in constant temperature culture oscillator after shaking 30min, is centrifuged 2min through centrifuge, discards
Supernatant liquid is added the Sevag reagent for being equivalent to volume 1/4, repeats the above process 7-8 times, removed by lower sediment
The solution of protein.
Step 5: obtaining that 95% ethyl alcohol is added in the solution of isolating protein to step 4, account for the volume of ethyl alcohol described molten
The 75% of liquid product, quickly stirs, makes polysaccharide homogeneous precipitation, overnight, precipitating is collected by centrifugation, and is dried in vacuo multiple by the precipitating
With polysaccharide.
Two, edible fungi polysaccharide gelling agent and preparation method thereof
Following embodiment matches in parts by weight.
Table 1
1) each embodiment carries out ingredient by table 1；
2) EDTA-2Na is dissolved in distilled water, is added with stirring carbomer, and accelerate swelling to be blocked in 60 DEG C of water-baths
Wave nurse glue；
2) it is soluble in water that polysaccharide will be compounded, glycerol is added, obtain polysaccharide solution after mixing evenly；
3) polysaccharide solution made from carbomer glue made from step 1 and step 2 is uniformly mixed to get more to edible mushroom
Sugared gelling agent.
Three, performance verification
1, moisture retention measures
It is configured with the compounding polysaccharide of different ratio, is then respectively placed in the vacuum oven of different relative humidity, is surveyed
The hydroscopicity and percentage of water loss of polysaccharide are compounded, is repeated aforesaid operations totally 3 times.
Percentage of water loss=M2/M1× 100%
In formula:
M2--- the biodiversity lost, g；
M1--- sample quality before placing, g.
Table 1 compounds polysaccharide when relative humidity is 43% in the hydroscopicity of different time
As shown in Table 1, for compounding polysaccharide (mushroom: tremella) in the case where relative humidity is 43%, hydroscopicity is respectively as follows: 1:
5 (20.65%) > 1:2 (18.95%) > 1:1 (15.35%) > 2:1 (14.20%) > 5:1 (12.10%).It can be seen that silver-colored
Ratio shared by fungus polysaccharides is more, and the hydroscopicity for compounding polysaccharide is better.
Table 2 compounds polysaccharide in relative humidity 81% in the hydroscopicity of different time
As shown in Table 2, compounding polysaccharide relative humidity be 81% in the case where, hydroscopicity be respectively 1:5 (36.05%) >
1:2 (31.60%) > 1:1 (23.60%) > 2:1 (21.20%) > 5:1 (18.70%), the feelings for being 43% in relative humidity with it
Result under condition is consistent, and tremella polysaccharides ratio is higher, and compounding polysaccharide hydroscopicity is better.
Table 3 compounds polysaccharide in relative humidity 43% in the moisturizing rate of different time
As shown in Table 3, when the mass ratio of lentinan and tremella polysaccharides is 1:2, guarantor of the polysaccharide in different time is compounded
The wet equal highest of rate, and moisturizing stability is best, without large change between 2h~10h.
It is configured with the preferable compound gel agent of different proportion moisturizing hygroscopicity, 3g is weighed respectively, is placed in relative humidity
In 43% vacuum oven, the percentage of water loss of gelling agent is surveyed, is repeated aforesaid operations totally 3 times, the results are shown in Table 4.
Percentage of water loss=M2/M1× 100%
In formula:
M2--- the biodiversity lost, g；
M1--- sample quality before placing, g.
Percentage of water loss of the 4 edible fungi polysaccharide gelling agent of table under relative humidity 43%
As shown in Table 4, each edible fungi polysaccharide compound gel agent is all than gel-type vehicle (being not added with edible fungi polysaccharide) percentage of water loss
Low and significant difference (P < 0.05), when mushroom and tremella ratio are 1:2 (embodiment 3), effect is best, and between 2~10h without compared with
Big variation.
2, the performance rating of gelling agent
The measurement of 2.1 pH value
Take test sample 5g, add water 50mL, with acidometer measurement pH value whether be in human normal skin surface pH value 5.0~
Between 7.0.
2.2 stability test
It takes test sample 10g to be respectively charged into two centrifuge tubes, 15min is centrifuged with revolving speed 4000r/min, if layering is put
It is placed in room temperature 30d, sees whether to deliquesce.
2.3 irritation test
Test sample is taken, is applied to after human ear on the inside of side and wrist, is observed after 1h, 4h, 6h and 8h after another ear and wrist,
Compared with not smearing skin, on it, whether there is or not influences.
Table 5
As can be seen from Table 5, compounding polysaccharide gel pH value prepared by the present invention is between normal skin surface pH, is applied
Smear it is nonirritant after application on human skin, it is without side-effects, be highly centrifuged not stratified, place do not deliquesce for a long time, it is with good stability.
Three, compounding polysaccharide gel is promoting the application in wound healing
Using male and healthy small white mouse 40,8 week old, body grows (10+0.5) cm, weight (15+3) g.Establishing wound mould
Before type, by small white mouse elder generation adaptable fed 5d.Remove back of mice chaeta with shaver, normal saline flushing is clean, to
Progress wound modeling in two days.Second day, first small white mouse is anaesthetized with ether, after disappeared with medicinal alcohol to its skin of back
Poison after disinfection, first lightly provokes skin surface at back of mice left of spine 0.5cm, then cut off one with scissors with tweezers
Diameter is the round full thickness skin of 0.5cm, if surface of a wound diameter is different, measures wound size with graduated scale, uses digital camera
Record the skin wound situation and size of mouse.Small white mouse is randomly divided into 4 groups, every group 10, the 1st group is blank control
Group, affected part smear 75% medicinal alcohol, totally 6；2nd group is positive controls, smears Yunnan Baiyao to small white mouse.3rd and 4
Group is experimental group, smears edible fungi polysaccharide gel prepared by embodiment 1 and embodiment 2 respectively, will after drug is absorbed by wound
Mouse carries out separator, is placed in raising, free feeding and drinking-water in cleaning cage, primary every coating for 24 hours later, dosage phase
Together, continue 7d.As a result as shown in Figure 1.
It will be seen from figure 1 that postoperative 3d, blank control group, experimental group and the positive controls surface of a wound grow new raw meat
Bud tissue has no oedema and secretion, and positive controls Yunnan Baiyao starts to form a scab, and edge starts to tilt, remaining does not start
Incrustation；The granulation tissue of postoperative 5d, each group surface of a wound increase, and surface of a wound area naked eyes, which are seen, to be also obviously reduced, experimental group and blank
The control group surface of a wound starts to form a scab, and the wound surface for smearing Yunnan Baiyao is all formed a scab；Postoperative 7d, each group surface of a wound area reduce
Obviously, experimental group and blank control group incrustation fall off, but positive controls Yunnan Baiyao is formed a scab and do not fallen off, blank control
Cicatricial tissue is formed after group wound healing, is generated after remaining group wound healing without cicatricial tissue.
When each coating observe the surface of a wound whether there is oedema and secretion, initially form incrustation time and edge tilt and
It forms a scab the time to fall off.Mouse carries out 1d, 3d, 5d, 7d after wound modeling, the diameter of the surface of a wound is measured respectively, with number
Cameras record wound site and data carry out observation analysis to photo and arrange to data.At the 7th day, according to before
Wound healing rate is obtained by calculation in data, evaluates the healing of the surface of a wound.Calculation formula is as follows:
P=(1-A1/A0The formula of) × 100% 1
In formula:
P --- Wound healing rate, %
A1--- existing wound area, mm2
A0--- original wound area, mm2
Postoperative 1d, 3d, 5d, 7d surface of a wound area of mouse is measured respectively, is denoted as S respectively1、S3、S5、S7, finally calculate the surface of a wound
Healing rate is denoted as P, and the results are shown in Table 6.
Table 6
Note: * has significant difference, p < 0.05 compared with the control group
As shown in Table 6,7d, the healing rate of the surface of a wound are 77.78% to control group after surgery；The wound of positive controls Yunnan Baiyao
Face healing rate is 84%；Experimental group smear embodiment 1 and 2 edible fungi polysaccharide gel Wound healing rate of embodiment be 87.5%,
92%.As it can be seen that edible fungi polysaccharide gel prepared by the present invention has significant facilitation to mouse skin wound healing.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not limitation with the present invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (6)
1. a kind of edible fungi polysaccharide gelling agent, which is characterized in that the component including following parts by weight: 1~2 part of polysaccharide of compounding,
10~20 parts of glycerol, 0.1~0.2 part of carbomer, 0.1~0.2 part of EDTA-2Na, 100~200 parts of water；The compounding polysaccharide is
The composition of lentinan and tremella polysaccharides.
2. edible fungi polysaccharide gelling agent according to claim 1, which is characterized in that lentinan and silver in the compounding polysaccharide
The mass ratio of fungus polysaccharides is 1:0.5~2.
3. edible fungi polysaccharide gelling agent according to claim 1, which is characterized in that the compounding polysaccharide is mentioned using following methods
It takes:
Step 1: powder will be ground into after mushroom and tremella fuciformis drying, deionized water is then added, 2h is extracted in boiling water bath, filtered
The first extracting solution and filter residue are obtained, deionized water is added into the filter residue, 2h is extracted in boiling water bath, second is obtained by filtration and mentions
Take liquid；The solid-to-liquid ratio of the powder and deionized water is 1g:25~30ml；
Step 2: the first extracting solution in step 1 and the second extracting solution being merged, and supernatant is collected by centrifugation, then the supernatant is placed in
In rotary evaporator, the 1/4~1/5 of original volume is concentrated into 90 DEG C and obtains concentrate；
Step 3: dehydrated alcohol will be added in concentrate that step 2 obtains, sediment is collected after centrifugation, then in 4 DEG C of precipitating 12h
The sediment is dried in vacuo to get crude extract is arrived；
Step 4: the crude extract that step 3 is obtained is dissolved in deionized water, removes the protein in solution with Sevag method, then
95% ethyl alcohol is added into the solution for go isolating protein, quickly stirs, makes polysaccharide homogeneous precipitation, overnight, precipitating is collected by centrifugation, it will
The precipitating is dried in vacuo to obtain compounding polysaccharide.
4. a kind of preparation method of edible fungi polysaccharide gelling agent as described in claim 1, which comprises the following steps:
1) EDTA-2Na is dissolved in distilled water, is added with stirring carbomer, and accelerate swelling to obtain carbomer in 60 DEG C of water-baths
Glue；
2) it is soluble in water that polysaccharide will be compounded, glycerol is added, obtain polysaccharide solution after mixing evenly；
3) polysaccharide solution made from carbomer glue made from step 1) and step 2) is uniformly mixed to get edible fungi polysaccharide is arrived
Gelling agent.
5. the preparation method of edible fungi polysaccharide gelling agent according to claim 4, which is characterized in that the edible fungi polysaccharide is solidifying
The concentration that polysaccharide is compounded in jelly is 0.006~0.012g/ml.
6. a kind of edible fungi polysaccharide gelling agent as described in claim 1 is promoting the application in wound healing.
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Application publication date: 20181221 |