CN1833715A - Skin care gel for skin titillation and prepn. thereof - Google Patents
Skin care gel for skin titillation and prepn. thereof Download PDFInfo
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- CN1833715A CN1833715A CN 200610000789 CN200610000789A CN1833715A CN 1833715 A CN1833715 A CN 1833715A CN 200610000789 CN200610000789 CN 200610000789 CN 200610000789 A CN200610000789 A CN 200610000789A CN 1833715 A CN1833715 A CN 1833715A
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- herba polygoni
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- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 37
- 208000003251 Pruritus Diseases 0.000 claims abstract description 26
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 109
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 81
- 239000007788 liquid Substances 0.000 claims description 51
- 238000003756 stirring Methods 0.000 claims description 36
- 238000001914 filtration Methods 0.000 claims description 34
- 238000002156 mixing Methods 0.000 claims description 34
- 238000005325 percolation Methods 0.000 claims description 34
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 27
- 229920002125 Sokalan® Polymers 0.000 claims description 27
- 229960001631 carbomer Drugs 0.000 claims description 27
- 239000002904 solvent Substances 0.000 claims description 27
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 21
- 239000012530 fluid Substances 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 17
- 239000000080 wetting agent Substances 0.000 claims description 12
- 230000002421 anti-septic effect Effects 0.000 claims description 11
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 10
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 10
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 10
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 9
- 239000004302 potassium sorbate Substances 0.000 claims description 9
- 235000010241 potassium sorbate Nutrition 0.000 claims description 9
- 229940069338 potassium sorbate Drugs 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 7
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 7
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 7
- 239000000758 substrate Substances 0.000 claims description 7
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims description 7
- 229940033663 thimerosal Drugs 0.000 claims description 7
- 229920002907 Guar gum Polymers 0.000 claims description 6
- 239000000665 guar gum Substances 0.000 claims description 6
- 235000010417 guar gum Nutrition 0.000 claims description 6
- 229960002154 guar gum Drugs 0.000 claims description 6
- 230000036541 health Effects 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 5
- 235000010199 sorbic acid Nutrition 0.000 claims description 5
- 229940075582 sorbic acid Drugs 0.000 claims description 5
- 239000004334 sorbic acid Substances 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 241000545442 Radix Species 0.000 claims description 4
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims description 3
- 229920002401 polyacrylamide Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- -1 tragcanth Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 18
- 201000004624 Dermatitis Diseases 0.000 abstract description 5
- 208000010668 atopic eczema Diseases 0.000 abstract description 5
- 201000009053 Neurodermatitis Diseases 0.000 abstract description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 1
- 241001671204 Stemona Species 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 229940041616 menthol Drugs 0.000 abstract 1
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 15
- 239000000796 flavoring agent Substances 0.000 description 13
- 235000019634 flavors Nutrition 0.000 description 13
- 230000000694 effects Effects 0.000 description 12
- 238000001556 precipitation Methods 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 10
- 201000010099 disease Diseases 0.000 description 9
- 239000002671 adjuvant Substances 0.000 description 8
- 208000020442 loss of weight Diseases 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 235000019445 benzyl alcohol Nutrition 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 239000002552 dosage form Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 229940098465 tincture Drugs 0.000 description 3
- 208000035357 Focal Infection Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 206010040882 skin lesion Diseases 0.000 description 2
- 231100000444 skin lesion Toxicity 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020852 Hypertonia Diseases 0.000 description 1
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 206010034719 Personality change Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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- 229920006243 acrylic copolymer Polymers 0.000 description 1
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- 201000007930 alcohol dependence Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 210000004727 amygdala Anatomy 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 239000011248 coating agent Substances 0.000 description 1
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- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
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- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
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- 235000013305 food Nutrition 0.000 description 1
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- 239000004615 ingredient Substances 0.000 description 1
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- 229920005615 natural polymer Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
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- 239000002674 ointment Substances 0.000 description 1
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Abstract
A Chinese medicine 'Kangfugel' for treating skin itching, eczema, neurodermatitis, etc is prepared from stemona root, Herba polygoni hydropiperis, menthol and auxiliary.
Description
Technical field
The present invention relates to a kind of skin-care gel that is used for skin pruritus and preparation method thereof, belong to technical field of Chinese medicine.
Technical background
Though skin pruritus performance clinically only has pruritus, there be not significantly former skin lesion, because pruritus often is a paroxysmal, especially with night for very, the person of being in a bad way must not sleep peacefully for a long time because acute pruritus, has neurasthenic symptoms such as dizziness, depressed, inappetence.Eczema, neurodermatitis are very common at department of dermatologry, account for department of dermatologry outpatient's about 50%, and cause of disease complexity, easily repeatedly, belong to one of difficult disease of department of dermatologry.
The common cause of skin pruritus has endocrine disturbance, pruritus hiemalis, hepatorenal disease, malignant tumor, spirituality factor, excessive cleaning skin etc.Neurodermatitis has another name called lichen chronicus simplex, is a kind of mainly to scratch where it itches and lichenification is the chronic dermatosis of feature, the Chang Fanfu outbreak.The primary disease cause of disease is still not exclusively clear and definite.It is generally acknowledged to be due to cerebral cortex excitement and inhibit feature are lacked of proper care. often because of morbidity or aggravations such as anxious state of mind, hypertonicity, neurasthenias.Local excitations such as digestive system disease, dyshormonia, focal infection, alcoholism, medicated clothing friction, Exposure to Sunlight perspiration all can inspire primary disease, aggravate disease.Eczema is a kind of common skin inflammatory reaction disease, and its characteristics are acute stage skin lesion pleomorphism (erythema, pimple, vesicle etc.), the tendency of oozing out are arranged, conscious scratching where it itches; Chronic phase, is often based on lichen sample pathological changes, easily repeatedly.The pathogenic factor complexity of eczema, multiple often internal and external factor interacts and causes a disease, belong to a kind of delayed allergy, stimulating food such as feed fish, shrimp, egg, beef and mutton suck certain pollen, dirt demodicid mite, Pilus Caprae seu Ovis etc., focal infection (amygdala inflammation, dental caries etc.), Enterozoa, the daylight in the living environment, sweltering heat, drying etc., number of chemical materials such as cosmetics, soap, synthetic fibers all can be pathogenic factors.
For the many oral antihistamines of above-mentioned disease doctor trained in Western medicine such as promethazine, chlorphenamine, diphenhydramine, but the drowsiness side effect of Denging is arranged; Corticosteroid hormone such as hydrocortisone ointment agent or cream etc., but easily recurrence after the drug withdrawal can not be effected a radical cure, and dependency and various untoward reaction are arranged after the prolonged application.Because the curative effect of Western medicine is general, taken dependency and various untoward reaction for a long time, and Chinese medicine has unique advantage aspect the disease that cures difficult and complicated cases always, pure Chinese medicinal preparation has been subjected to more patients' favor.Health skin tincture with its good curative effect on market always in occupation of suitable share, it is higher that right because tincture generally contains the alcohol amount, storage, transportation are inconvenient, easily skin being produced in use stimulates, and then makes it be subjected to very big restriction in clinical use.For this reason, develop a kind of determined curative effect, take, storage, convenient transportation, be easier to just to be seemed particularly important by the novel dosage form that extensive patients is accepted.
Gel is one of most active in recent years medicine novel form, is the focus of local topical preparation research and development in recent years, has smooth in appearance, transparent exquisiteness; Nonirritant does not hinder the normal function of skin; Denseness, viscosity suit, and are easy to coating and use, and it is very convenient to carry, use, preserve, transport, advantages such as good stability.For this reason, the inventor has developed a kind of novel gel preparation from the character of medicine itself and the characteristics and the modern requirement of Chinese medicine preparation of surgery local application.By retrieval, this gel still belongs to internal blank.
Summary of the invention
The object of the present invention is to provide a kind of new pharmaceutical preparation and preparation method thereof, this invention preparation mainly adds proper auxiliary materials by the Radix Stemonae, Herba polygoni hydropiperis, Mentholum and is prepared from, have skin moistening and itch stopping, the effect that parasite killing is deodorized is used for skin prurituss such as various skin pruritus, eczema, neurodermatitis.In the side, Radix Stemonae slightly warm in nature, sweet in the mouth, hardship, external has insecticidal action; Herba polygoni hydropiperis acrid in the mouth, warm in nature has dehumidifying, changes the function that stagnates, external treatment skin pruritus; Mentholum acrid in the mouth, cool in nature has effects such as dispelling wind, heat clearing away, detoxifcation, diseases such as external curing skin pruritus due to wind pathogen.Three medicines share plays skin moistening and itch stopping, the effect that parasite killing is deodorized altogether.This medicine is through clinical use, determined curative effect, and nontoxic, side effect.Gel of the present invention is applied in the affected part; no greasy feeling; good with the skin coupling; good absorbing; and can form the very thin protecting film of one deck at pars affecta skin after smearing, have protection and wetting action, and carry, store, transport all more convenient; stability improves greatly simultaneously, and then has obviously improved the curative effect of medicine and patient's facility.
The present invention is achieved through the following technical solutions:
A kind of skin-care gel that is used for skin pruritus is characterized in that, counts by weight percentage, count by weight percentage, it is mainly by health skin percolate 72-85%, Mentholum 0.2%, and substrate 0.2-2%, wetting agent 2-12%, antiseptic 0.1-0.5%, solvent 0.3-25.5% are prepared from.Calculate by weight, health skin percolate mainly is prepared from for 50 parts by 200 parts of the Radixs Stemonae, Herba polygoni hydropiperis.Antiseptic comprises one or more in sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, the thimerosal, substrate comprises one or more in sodium alginate, xanthan gum, guar gum, tragcanth, arabic gum, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, polyacrylamide, cross linked sodium polyacrylate, Polyethylene Glycol, the carbomer, and wetting agent comprises one or both in glycerol, the propylene glycol; Solvent comprises one or both in water, the Different concentrations of alcohol.
Gel-type vehicle is carbomer preferably, and by weight percentage, the carbomer consumption is at 0.3-0.7%; Wetting agent is glycerol preferably, and by weight percentage, the glycerol consumption is at 3-7%; Antiseptic is ethyl hydroxybenzoate preferably, and solvent is meant 50% ethanol.
A kind of preparation method that is used for the skin-care gel of skin pruritus is:
Calculate by weight, the skin-care gel raw material consists of: 200 parts of the Radixs Stemonae, 50 parts of Herba polygoni hydropiperis.
Skin-care gel of the present invention is preparation like this: the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1-3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, and with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, add Mentholum, gel-type vehicle, wetting agent, antiseptic stir and make dissolving, add solvent to full dose, stir, make gel, promptly.
Specifically, gel is preparation like this:
(1) by weight (part is gram), raw material of the present invention consists of: Radix Stemonae 200g, Herba polygoni hydropiperis 50g, Mentholum 2g;
(2) Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, and mixing is according to the percolation (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1-3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, and with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, add Mentholum, carbomer 5.0g, glycerol 50.0g, ethyl hydroxybenzoate 2.0g stir and make dissolving, add solvent to full dose, stir, make gel, promptly.
At prior art, it is higher that health skin tincture contains the alcohol amount, and storage, transportation are extremely inconvenient, easily skin produced drawbacks such as stimulation in use; Novel gel dosage form has been developed in the characteristics of bound drug character of the present invention and medicine for external use and the modern requirement of Chinese medicine preparation.The present invention is through a large amount of experiments, to gel-type vehicle.Adjuvants such as wetting agent carry out preferably, have carried out systematic research to the consumption of its adjuvant and with relevant nature that medicine is used.The gel smooth in appearance that the present invention makes, transparent exquisiteness; No greasy feeling is applied in the affected part, and is good with the skin coupling, good absorbing, and, have protection and humidification at skin surface formation protecting film, and the part is non-stimulated, does not hinder the normal function of skin, and it is very convenient to preserve, transport, carry.
The inventor finds that in development process kind, the consumption of adjuvant have considerable influence to it, and for this reason, the applicant has carried out a series of experiments, to prove beneficial effect of the present invention.
The experimental example Study on Forming
1, the gel-type vehicle kind is selected
Gel has the branch of aqueous gel and oil-base gel, and aqueous gel is because of its excellent biological compatibility, adhesiveness, no greasy feeling, and easy cleaning, pollution clothes is used more in the external dosage form.The aqueous gel adjuvant has natural polymer subclass such as xanthan gum, guar gum, arabic gum etc., cellulose derivative such as hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (CMC-Na), synthetic macromolecular compound carbomer etc.
Test method: the substrate with above-mentioned usual amounts adds respectively in the percolate earlier, stirs, and the results are shown in Table 1.
Table 1 gel-type vehicle kind is preferably shown
| Supplementary product kind | Consumption (%) | The result |
| HPMC carbomer CMC-Na xanthans guar gum Arabic gum sodium alginate tragcanth polyacrylamide cross linked sodium polyacrylate polyethylene glycol | 0.9 0.4 1.0 1.0 1.0 5 5 5 2 2 4 | Make even gel, do not have precipitation and separate out.Make even gel, clarity is better, does not have precipitation and separates out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out.Make even gel, do not have precipitation and separate out. |
Table 1 shows, above-mentioned most adjuvant all can satisfy the preparation requirement substantially, the use that cooperatively interacts of the adjuvant of above usual amounts, wherein any one and/or all the other one or more adjuvants are joined and also can be made even gel when using, but be that the every index of gel made of substrate is all more satisfactory especially with the carbomer, so preferred carbomer is as skin-care gel substrate.
2, carbomer consumption screening
Carbomer is an acrylic copolymer with macromolecule, is great swelling state after aqueous dispersion is neutralized, and by thickening, consumption seldom in gel.In order to make the gel that viscosity is moderate, be fit to external, the carbomer consumption is screened.
Carbomer that will be not commensurability adds in the percolate respectively, stirs result such as table 2.
Table 2 carbomer consumption is preferably shown
| Consumption (%) | The result |
| 0.2 0.3 0.5 0.7 0.8 1.4 2.0 | It is rarer to make gel, and scribble effect is better.Make the gel stickiness and be fit to, easily smear.Make the gel stickiness and be fit to, easily smear.Make the gel stickiness and be fit to, easily smear.It is more sticky to make the gel stickiness, more easily smears.It is more sticky to make gel, more easily smears.It is more sticky to make gel, and scribble effect is better. |
According to table 2 result, the consumption of carbomer all can satisfy the preparation requirement substantially at 0.2-2.0%, and carbomer consumption obtained gel when 0.3-0.7% is better.
3, the glycerol consumption is investigated
In order to keep moisture preserving time and the comfortableness of gel on skin, the assurance drug absorption is complete, generally to add wetting agent, wetting agent commonly used has glycerol, propylene glycol etc., through trial test, uses glycerol or propylene glycol or the two mixture and all can play moisture-keeping function, and glycerol can dissolve Carbopol 941, and in gel rubber system, do not influence the dissolubility of ingredient and other adjuvant, therefore select for use glycerol, and consumption is screened as wetting agent.
Get transparent paraffin paper and be cut into a certain size, weigh again after evenly being coated with the last layer skin-care gel after precision is weighed, place respectively at about 25 ℃ and 37 ℃ and take out after 8 hours, weigh, determine the water evaporates situation.The results are shown in Table 3.
Table 3 glycerol consumption is preferably shown
| Glycerol consumption (%) | 25 ℃ | 37 ℃ |
| 2357 12 | Loss of weight 2.8%.Loss of weight 1.5 losss of weight 1.1%.Loss of weight 1.0 losss of weight 0.5%. | Loss of weight 3.5%.Loss of weight 1.2 losss of weight 1.0%.Loss of weight 0.8 loss of weight 0.9%. |
As shown in Table 7, the glycerol consumption can play the moisturizing effect substantially between 2～12%, and consumption can play moisture-keeping function preferably when 3-7%.
According to documents and materials, antiseptic often uses sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, thimerosal, consumption can play antisepsis when 0.1-0.5%, through trial test, gel of the present invention adopts single or compound antiseptic antiseptic effect when this consumption good.
Experimental example 2: preparation stabilization Journal of Sex Research
Be to investigate the stability of preparation process, the gel fill in aluminium collapsible tube, was placed 40 ℃, the climatic chamber of relative humidity 75% 1 month, character changes before and after the viewing test.The results are shown in Table 4.
Table 4 preparation stability investigation table
| Sample | Appearance character |
| After testing before the test | Orange-yellow clear gel, the moderate orange-yellow clear gel of viscosity, viscosity is moderate |
Accelerated test shows before and after this medicine test does not have significant change in appearance color, physical behavior, illustrates that this medicine is basicly stable, and technology is reasonable.
Concrete embodiment
Embodiment 1: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 850g, add Mentholum, carbomer 5.0g, glycerol 50.0g, ethyl hydroxybenzoate 2.0g, stirring makes dissolving, adds distilled water 91g to full dose, stirs, make gel 1000g, promptly.
Embodiment 2: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 720g, add Mentholum, carbomer 2.0g, glycerol 20.0g, sorbic acid 1.0g, stirring makes dissolving, adds 50% ethanol 255g to full dose, stirs, make gel 1000g, promptly.
Embodiment 3: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 795g, add Mentholum, carbomer 8.0g, glycerol 100.0g, ethyl hydroxybenzoate 1.0g, benzyl alcohol 2.0g stirs and makes dissolving, add 75% ethanol 92g to full dose, stir, make gel 1000g, promptly.
Embodiment 4: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 822g, adds Mentholum, xanthan gum 2.0g, guar gum 3.0g, glycerol 20.0g, propylene glycol 10.0g, sorbic acid 1.0g, thimerosal 1.0g, benzyl alcohol 2g stirs and makes dissolving, adds 80% ethanol 137g to full dose, stirs, make gel 1000g, promptly.
Embodiment 5: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, heavy 780g, add Mentholum, hydroxypropyl methylcellulose 1.0g, sodium carboxymethyl cellulose 4.0g, glycerol 80.0g, potassium sorbate 1.5g stirs and makes dissolving, add distilled water 131.5g to full dose, stir, make gel 1000g, promptly.
Embodiment 6: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 840g, add Mentholum, xanthan gum 2.0g, guar gum 3.0g, glycerol 107.0g, propylene glycol 10.0g, potassium sorbate 2.0g stirs and makes dissolving, add distilled water 34g to full dose, stir, make gel 1000g, promptly.
Embodiment 7: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 788g, add Mentholum, cross linked sodium polyacrylate 20.0g, propylene glycol 50.0g, ethyl hydroxybenzoate 3.0g stirs and makes dissolving, add distilled water 137g to full dose, stir, make gel 1000g, promptly.
Embodiment 8: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 850g, add Mentholum, carbomer 20.0g, glycerol 120.0g, potassium sorbate 5.0g, stirring makes dissolving, adds 50% ethanol 3g to full dose, stirs, make gel 1000g, promptly.
Embodiment 9: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 820g, add Mentholum, carbomer 15.0g, propylene glycol 110.0g, potassium sorbate 4.0g, stirring makes dissolving, adds distilled water 48g to full dose, stirs, make gel 1000g, promptly.
Embodiment 10: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 840g, add Mentholum, carbomer 5.0g, glycerol 50.0g, benzyl alcohol 5.0g, stirring makes dissolving, adds 50% ethanol 98g to full dose, stirs, make gel 1000g, promptly.
Embodiment 11: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 810g, add Mentholum, carbomer 3.0g, glycerol 30.0g, thimerosal 5.0g, stirring makes dissolving, adds 50% ethanol 150g to full dose, stirs, make gel 1000g, promptly.
Embodiment 12: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 790g, adds Mentholum, carbomer 7.0g, glycerol 70.0g, thimerosal 2.0g, potassium sorbate 0.5, benzyl alcohol 0.5g, stirring makes dissolving, adds 50% ethanol 128g to full dose, stirs, make gel 1000g, promptly.
Embodiment 13: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 810g, adds Mentholum, hydroxypropyl methylcellulose 7.0g, glycerol 70.0g, thimerosal 2.0g, potassium sorbate 0.5, benzyl alcohol 0.5g, stirring makes dissolving, adds 50% ethanol 128g to full dose, stirs, make gel 1000g, promptly.
Claims (7)
1, a kind of skin-care gel that is used for skin pruritus, it is characterized in that, count by weight percentage that it is mainly by health skin percolate 72-85%, Mentholum 0.2%, substrate 0.2-2%, wetting agent 2-12%, antiseptic 0.1-0.5%, solvent 0.3-25.5% are prepared from.
2, a kind of skin-care gel that is used for skin pruritus according to claim 1 is characterized in that, calculates by weight, and health skin percolate mainly is prepared from for 50 parts by 200 parts of the Radixs Stemonae, Herba polygoni hydropiperis.
3, a kind of skin-care gel that is used for skin pruritus according to claim 1, it is characterized in that substrate comprises one or more in sodium alginate, xanthan gum, guar gum, tragcanth, arabic gum, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, polyacrylamide, cross linked sodium polyacrylate, Polyethylene Glycol, the carbomer; Wetting agent comprises one or both in glycerol, the propylene glycol; Antiseptic comprises one or more in sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, the thimerosal; Solvent comprises one or both in water, the Different concentrations of alcohol.
4, a kind of skin-care gel that is used for skin pruritus according to claim 3, it is characterized in that: gel-type vehicle is meant carbomer; Wetting agent is meant glycerol; Antiseptic is meant ethyl hydroxybenzoate, and solvent is meant 50% ethanol.
5, according to a kind of skin-care gel that is used for skin pruritus described in the claim 1,4, it is characterized in that: by weight percentage, the carbomer consumption is at 0.3-0.7%; The glycerol consumption is at 3-7%.
According to any described a kind of preparation method that is used for the skin-care gel of skin pruritus among the claim 1-5, it is characterized in that 6, gel is preparation like this:
(1) calculate by weight, raw material of the present invention consists of: 200 parts of the Radixs Stemonae, 50 parts of Herba polygoni hydropiperis, 2 parts of Mentholums;
(2) Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, and mixing is according to the percolation (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1-3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, and with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, add Mentholum, gel-type vehicle, wetting agent, antiseptic stir and make dissolving, add solvent to full dose, stir, make gel, promptly.
7, a kind of preparation method that is used for the skin-care gel of skin pruritus according to claim 6 is characterized in that, gel is preparation like this:
(1) by weight (part is gram), raw material of the present invention consists of: Radix Stemonae 200g, Herba polygoni hydropiperis 50g, Mentholum 2g;
(2) Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, and mixing is according to the percolation (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1-3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, and with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, add Mentholum, carbomer 5.0g, glycerol 50.0g, ethyl hydroxybenzoate 2.0g stir and make dissolving, add solvent to full dose, stir, make gel, promptly.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332244B (en) * | 2008-06-06 | 2011-12-21 | 叶志军 | Oral traditional Chinese medicine for treating diffused neurodermatitis |
| CN103223110A (en) * | 2013-04-30 | 2013-07-31 | 布焕景 | External traditional Chinese medicine composition for treating female pruritus vulvae and preparation method thereof |
| CN106138190A (en) * | 2016-08-08 | 2016-11-23 | 林湧博 | A kind of external-use gel preparation, preparation method and its usage |
| CN106620445A (en) * | 2016-11-09 | 2017-05-10 | 安徽安科余良卿药业有限公司 | Skin-rehabilitating microemulsion gel and preparation method thereof |
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2006
- 2006-01-11 CN CNB2006100007896A patent/CN100569217C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332244B (en) * | 2008-06-06 | 2011-12-21 | 叶志军 | Oral traditional Chinese medicine for treating diffused neurodermatitis |
| CN103223110A (en) * | 2013-04-30 | 2013-07-31 | 布焕景 | External traditional Chinese medicine composition for treating female pruritus vulvae and preparation method thereof |
| CN103223110B (en) * | 2013-04-30 | 2014-08-06 | 赵彦梅 | External traditional Chinese medicine composition for treating female pruritus vulvae and preparation method thereof |
| CN106138190A (en) * | 2016-08-08 | 2016-11-23 | 林湧博 | A kind of external-use gel preparation, preparation method and its usage |
| CN106138190B (en) * | 2016-08-08 | 2020-03-31 | 浙江奕箔生物科技有限公司 | External gel preparation, preparation method and application thereof |
| CN106620445A (en) * | 2016-11-09 | 2017-05-10 | 安徽安科余良卿药业有限公司 | Skin-rehabilitating microemulsion gel and preparation method thereof |
| CN106620445B (en) * | 2016-11-09 | 2020-01-03 | 安徽安科余良卿药业有限公司 | Skin-care microemulsion gel and preparation method thereof |
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