CN101337026A - External medicine composition for treating gout - Google Patents
External medicine composition for treating gout Download PDFInfo
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- CN101337026A CN101337026A CNA200810058822XA CN200810058822A CN101337026A CN 101337026 A CN101337026 A CN 101337026A CN A200810058822X A CNA200810058822X A CN A200810058822XA CN 200810058822 A CN200810058822 A CN 200810058822A CN 101337026 A CN101337026 A CN 101337026A
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Abstract
The invention relates to a medicament composition for external administration, which cures arthrolithiasis, in particular to a medicament composition for external administration, which cures arthrolithiasis and is prepared from the Chinese medicinal plant herb. The medicament composition for curing arthrolithiasis is a preparation for external administration prepared from the following raw materials by the weight ratio: 16 to 68 parts of Iphigenia indica A.Gray, 16 to 68 parts of scandent schefflera root, 16 to 68 parts of Yunnan craibiodendron leaf, 16 to 68 parts of Tali falsehellebore herb, 16 to 68 parts of amoorcorn tree bark, 16 to 68 parts of bletillae rhizome, 16 to 68 parts of rhubarb and 2 to 10 parts of menthol. The medicament composition for external administration is used for curing the arthrolithiasis disease.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of gout, particularly a kind of is the external medicine preparation compositions of the treatment gout made of raw material with the vegetable Chinese herbal medicine.
Background technology
Gout is because heritability or the acquired cause of disease cause purine metabolism obstacle and serum uric acid to continue the caused disease that raises. it is that excessive production of uric acid or uric acid row are rushed down insufficient uric acid that causes and piled up and cause, uric acid crystal is deposited in cartilage, soft tissue, kidney and joint.Deposition at joint can cause violent pain.Clinical manifestation is that hyperuricemia (hyperuriccmia) and characteristic acute arthritis, tophus form, the tophus chronic arthritis, and urate nephropathy can take place, uric acid lithangiuria etc., and severe patient the joint can occur and disable, renal insufficiency.Gout normal and central obesity hyperlipidemia, diabetes, hypertension and cardiovascular and cerebrovascular disease occur together.
In recent years, along with the raising of China's living standards of the people, life-time dilatation, the change (food that is rich in nucleoprotein increases) of dietary structure, overweight people's increase, the sickness rate of goat also is the trend of rising.Clinical treatment is mainly based on colchicine, nonsteroidal antiinflammatory drug, hormone, promotion urate excretion medicine (as probenecid, sulfinpyrazone and benzbromarone) and inhibition uric acid synthetic drug (allopurinol) at present.Acute period of disease is mainly used colchicine, nonsteroidal antiinflammatory drug, hormone, and the catabasis is mainly used and promotes urate excretion medicine, inhibition uric acid synthetic drug.From clinical, the present kind of anti-gout drugs is few, and is old product mostly, and the untoward reaction of western medicine gout is bigger, has the GI irritation effect as colchicine and indometacin, and the former also produces leucocytes reduction and alopecia etc.; Probenecid, benzbromarone have gastrointestinal reaction, kidney strand carbuncle and excite side effect such as gout acute attack; Allopurinol has serious toxic and side effects such as the allergy of causing, super quick Stevena-Johnson syndrome, bone marrow depression.Effect is not satisfactory, only is applicable to the treatment of acute stage, should not take for a long time.Acute gouty arthritis, i.e. the modal first symptom of gout, its onset is anxious, sharp ache, more than night-time attack, the performance of red and swollen heat pain is arranged around the joint.The first joint of patients more than half is big toe, sole of the foot toe, ankle, knee joint, refer to, wrist, elbow joint also are predilection site, and acute inflammation shows effect repeatedly and can cause joint stiffness, deformity.Bring huge misery to the patient, and few at the external curing medicine of acute gouty arthritis, often be some national folk unguentum, be used for expelling wind and cold, the eliminating impediment pain relieving.Gout mostly belongs to damp and hot numbness category at differential diagnosis in tcm, its pathogenesis or because of the natural endowment deficiency, or because of the eating and drinking without temperance day after tomorrow, visceral dysfunction, distinguish not turbid not normal, so wet, heat, the stasis of blood, the life thereupon of turbid all diseases.This disease is the definite Chinese medicine preparation reliably of inefficacy still at present.
It is to be to allocate Radix Aconiti, Radix Aconiti Kusnezoffii, Flos Carthami, Herba Asari, Rhizoma Et Radix Notopterygii, Herba Achilleae in the wine of 1kg40-65 degree for a Chinese patent 200410036755.3 open " Chinese medicine wine for external use of treatment gout ", makes Chinese medicine wine for external use; Chinese patent 200410040457.1 discloses by Cortex Phellodendri, Rhizoma Coptidis, Herba Taraxaci, Radix Achyranthis Bidentatae, Borneolum Syntheticum and has been prepared into external use plaster; Chinese patent 03117636.4 discloses " a kind of external used medicine for the treatment of gout and preparation method thereof ", and it is to select to comprise that Herba Verbenae, Radix Zanthoxyli Spinifolii, Radix Berberidis, Rhizoma Polygoni Cuspidati, Flos Carthami, Chinese liquor make up, and makes tincture treatment gout.In addition, the Chinese medicine composition of all the other treatment gouts is oral formulations, constitutes more complicated, and the quality of production is restive.Cost is higher, and human body is more or less had certain toxic and side effects.
Summary of the invention
Purpose of the present invention is intended to provide a kind of Chinese medicine for external application for the treatment of gout and preparation method thereof, and this medicine means that some Chinese medicines with therapeutical effect and the substrate combination that suits form.It is to directly act on lesions position, and therapeutic effect is good, and is little to systemic side effects, preparation safe in utilization.
The externally-applied medicinal composition of treatment gout of the present invention is the exterior-applied formulation of being made by following materials of weight proportions: iphigenia indica 16-68 part, stem and leaf of Radix Schefflerae Arboricolae 16-68 part, Folium Craibiodendri Yunnanensis 16-68 part, Herba Veratri Taliensis 16-68 part, Cortex Phellodendri 16-68 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 16-68 part, Radix Et Rhizoma Rhei 16-68 part, Mentholum 2-10 part.
Result of the test shows, in said drug effect medicinal ingredient, especially composition weight effect than for 6 parts of 42 parts of iphigenia indicas, 42 parts of stem and leaf of Radix Schefflerae Arboricolae, 42 parts of Folium Craibiodendri Yunnanensiss, 42 parts of Herba Veratri Taliensis, 42 parts of Cortex Phellodendris, 42 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 42 parts of Radix Et Rhizoma Rhei, Mentholum the time is best
This prescription meets Chinese medical theory, has certain clinical practice basis, cures mainly to be the bonded Chinese medicine compound of disease, and it is prescription under Chinese medical theory instructs: wherein iphigenia indica, Herba Veratri Taliensis, Radix Et Rhizoma Rhei, divinatory symbol by name and, the divinatory symbol preface is placed in the middle, the five elements be wooden, corresponding internal organs: liver, main bone, six colors are gone into green grass or young crops.Iphigenia indica has " heat-clearing and toxic substances removing, dispersing swelling and dissipating binds "; Herba Veratri Taliensis has " vomiting wind-phlegm by emesis, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, parasite killing degree "; Radix Et Rhizoma Rhei has: the function of " purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation ".Stem and leaf of Radix Schefflerae Arboricolae, Folium Craibiodendri Yunnanensis belong to feeds, divinatory symbol house by name, and the divinatory symbol preface is placed in the middle, and the five elements are gold, corresponding internal organs: lung, main muscle, six colors are gone into white.Stem and leaf of Radix Schefflerae Arboricolae has " vital energy regualting and blood circulation-promoting, reducing swelling and alleviating pain ", and Folium Craibiodendri Yunnanensis has the function of " eliminating stasis to stop pain, expelling wind and removing dampness ".Cortex Phellodendri belongs to, and divinatory symbol are by name, hangs preface and occupies length, and the five elements are fire, corresponding internal organs: the heart, and main QI and blood, six colors are gone into red, and the function of " heat clearing and damp drying, eliminating fire and detoxication " is arranged.Pseudobulbus Bletillae (Rhizoma Bletillae) in the prescription, Herba Menthae (brain) are the auxiliary medical material of external agent, get the stickup effect that Pseudobulbus Bletillae (Rhizoma Bletillae) has, to strengthen the attaching and the action time of medicine; Utilize the thin cave of Herba Menthae (brain) to convince refrigerant work by patient analysis in order to quick elimination or alleviate the pain and the sense of discomfort of affected part.
This prescription is made external preparation in accordance with the following methods: above-mentioned all the other seven flavor medicine materials except that Mentholum are ground into coarse powder, mixing
(1) flood at twice with 65% ethanol, each 30 days, merge impregnation liquid, filter, collect filtrate;
(2) with 65% ethanol percolation, flooded 48 hours, percolate is collected in diafiltration, leaves standstill 24 hours, filters;
(3) get filtrate in (1) or (2), make aerosol, gel, liniment, medicated wine, tincture, lotion, spray, cataplasma, patch, liniment, ointment according to the following steps respectively:
1. after above-mentioned filtrate being added the Mentholum mixing, medicinal liquid is poured in the clean container, be pressed into third butane or halothane class or gas of dimethyl ether, promptly get aerosol with pressing machine;
2. with above-mentioned filtrate recycling ethanol, being concentrated into relative density is the thick paste of 1.20～1.25 (50 ℃); Take by weighing an amount of glycerol, add in the above thick paste, make its abundant mixing dissolve, put cold; With 95% dissolve with ethanol Mentholum, standby with the thick paste mixing that obtains, promptly get gel with gel-type vehicle carbomer or cellulose derivative or sodium alginate or the abundant stirring and evenly mixing of carbopol;
3. above-mentioned filtrate is added Mentholum, mixing, packing promptly gets liniment, medicated wine, tincture, lotion;
4. above-mentioned filtrate is added Mentholum, solvent, antioxidant, surfactant mixing, liquid medicine filling is promptly got spray in sprayer unit;
5. with above-mentioned filtrate recycling ethanol, being concentrated into relative density is the thick paste of 1.20～1.25 (50 ℃); Put cold; With 95% dissolve with ethanol Mentholum,, standby with the thick paste mixing that obtains, be prepared into rubber cement with catablasm base material sodium polyacrylate or Sodium Tvlose or mixings such as gelatin, glycerol and micropowder silica gel, after gluing, cutting, lid lining are cut into segment, packing promptly gets cataplasma;
6. with above-mentioned filtrate recycling ethanol, being concentrated into relative density is the thick paste of 1.20～1.25 (50 ℃), puts cold, with 95% dissolve with ethanol Mentholum,, standby with the thick paste mixing that obtains, with mixings such as patch substrate ethylene-vinyl acetate copolymer, silicone rubber and Polyethylene Glycol, will mount respectively material, medical mylar and spice are packed in the patch spreading equipment, adjuvant, roll, after the molding, dicing, microwave sterilizating, packing, sealing, packing promptly gets patch;
7. above-mentioned filtrate is added Mentholum, the filmogen polyethylene mixings such as first and second aldehyde or polyvinyl butyral or collodion etc., plasticizer phthalic acid dibutyl ester that contract, packing promptly gets liniment;
8. with above-mentioned filtrate recycling ethanol, being concentrated into relative density is the thick paste of 1.20～1.25 (50 ℃), put cold, standby with 95% dissolve with ethanol Mentholum with the thick paste mixing that obtains, promptly get ointment with the ointment base mixing.
Gained gel exquisite quality, color and luster is even, denseness is suitable, stretchability is good, meets regulation under the Chinese Pharmacopoeia gel item.Get product 5g, measure after adding the 25ml distilled water diluting.PH value is 6～8, meets the external preparation acid-base value and is not more than 8.0 requirement.Sample thief is an amount of, is loaded in the hermetic container, places 55 ℃ respectively, and-15 ℃ and room temperature were placed three months, and sample does not have layering, no catabiosis.
Have quick-acting and positioning action after making aerosol, aerosol is sprayed directly on to site of action, is evenly distributed, and is rapid-action; But the medicine airtight package is avoided air, moisture, and the light influence improves medicine stability; Can avoid first pass effect of hepar and gastrointestinal destruction; Local application's zest is little; And aerosol can pass through the proportional valve dosed administration, provides good assurance to the safe handling of poisonous medical material, is better than advantages such as general external preparation.
After making cataplasma skin there are not allergy, irritant reaction, painless and residual when peeling off; Strong to low ionic strength and water-soluble component bearing capacity; In the production process not with an organic solvent, environmentally safe; Higher water content can promote that medicine discharges to skin from patch, and moisture the time can take away heat on the skin in evaporation, brings cooling feeling.
It is remarkable that the present invention treats the curative effect of medication of gout, and do not have overt toxicity and side effect, studies show that through pharmacodynamics test have significant antiinflammatory, analgesic effect, can reducing swelling and alleviating pain, treatment gouty congestion and swelling pain.
In order to prove effectiveness of the present invention and safety, a series of experiments have been carried out.
(1) preliminary acute toxicity test
Carry out the acute toxicity pilot study by " medicine registration management way " requirement.Select percutaneous maximum dosage-feeding test in the rabbit 24 hours, be divided into 2 groups at random, be i.e. blank group and administration group, respectively 3 of every group of male and female with 12 of rabbit.Back part of animal skin is by skin 10cm * 15cm, fasting be can't help water after one night, the administration group gives gold seven beautiful aerosols (present composition) by 15g crude drug/kg.bw skin, and matched group gives 65% ethanol with volume, animal local response and whole body acute toxic reaction after the observation administration.
The result shows, the percutaneous maximum dosage-feeding is 15g crude drug/kg.bw in the gold seven beautiful rabbit 24 hours, and animal skin, the mental status, behavior, diet, outward appearance, secretions, Excreta etc. there is no unusually after the administration.During the experimental observation, do not see that toxicity and death appear in animal, observation in 14 days finishes the back sacrifice of animal is carried out gross anatomy, and the volume of medicine-feeding part skin, each internal organs, organ, color, quality etc. there is no unusually.Seven beautiful groups of rabbit body weight gains of 14 days gold and blank group compare there was no significant difference (p＞0.05) after the administration.
(2) part pharmacodynamic study
1. to the effect of gouty arthritis
1.1 urate is induced the influence of rat gouty arthritis
Get 80 of 180-200g male SD rats, grouping and administration situation see Table 1, for three days on end; After the last administration 30 minutes, except that the blank group the foot pad injecting normal saline 0.05ml of portion of the right side, all the other each groups are induced the generation of gouty arthritis at the injection uric acid sodium normal saline 0.05ml of right side foot pad portion.Respectively with vernier caliper measurement cause scorching before and cause the thickness of the right sufficient pad of scorching back 1h, 2h, 4h, 6h and 8h rat portion so that the difference before and after scorching is as the swelling degree of gouty arthritis, take the mean and matched group relatively, carry out statistical test, the results are shown in Table 1
Table 1 gold seven beautiful aerosols to the influence of rat gouty arthritis (x ± s, n=10)
Compare with blank:
▲ ▲P＜0.05,
▲ ▲P＜0.01.Compare with model group:
*P＜0.05,
*P＜0.01.
Compare with the solvent group:
Result of the test shows: after the urate modeling, model group and blank group relatively have significant difference (P＜0.01), prove the success of the inductive rat gouty arthritis of urate model.With model group relatively gold seven beautiful aerosols high, medium and low dosage group in different time points the inductive rat paw edema of urate is all had significant inhibitory effect, gold seven beautiful aerosol low dose group 1h after modeling have significant inhibitory effect (P＜0.05), show that gold seven beautiful low dosages have the inhibitory action of morning to inflammation.And solvent does not have obvious influence to this model, and prompting gold seven beautiful aerosols are to be caused by medicine to the inhibitory action of inflammation, rather than the solvent generation.
1.2 influence to urate inducing mouse gouty arthritis
Get 80 of 20-23g male mices, grouping and administration situation see Table 2, for three days on end; After the last administration 30 minutes, except that the blank group the foot pad injecting normal saline 0.05ml of portion of the right side, all the other each groups are induced the generation of gouty arthritis at the injection uric acid sodium normal saline 0.05ml of right side foot pad portion.Respectively with vernier caliper measurement cause scorching before and cause the diameter at 0.5cm place under scorching back 1h, 2h, 4h and the 6h mice limb joint so that the difference before and after scorching is as the swelling degree of gouty arthritis, takes the mean and matched group compares, and carries out statistical test.The results are shown in Table 2.
Table 2 gold seven beautiful aerosols to the influence of mice gouty arthritis (x ± s, n=10)
Compare with blank:
▲ ▲P＜0.05,
▲ ▲P＜0.01.Compare with model group:
*P＜0.05,
*P＜0.01.
Compare with the solvent group:
Result of the test shows: after the urate modeling, model group and blank group relatively have significant difference (P＜0.01), prove the success of the inductive mice gouty arthritis of urate model.With model group relatively gold seven beautiful aerosols high, medium and low dosage group in different time points the inductive mice foot swelling of urate is all had remarkable inhibitory action, in the gold seven beautiful aerosols, low dose group 1h after modeling has the inhibitory action (P＜0.01) of highly significant, shows in the gold seven beautiful aerosols, low dosage has early inhibitory action to inflammation; And solvent does not have obvious influence to this model, and prompting gold seven beautiful aerosols are to be caused by medicine to the inhibitory action of inflammation, rather than the solvent generation.
2. to the influence of general inflammation
2.1 xylol causes the influence of mice auricle swelling
Get 70 of 18-22g mices, male and female half and half, grouping and administration see Table 3, and each treated animal every day is auris dextra coating 1 time according to dosage, for three days on end, administration in the 3rd day is after 30 minutes, and 0.05ml caused by dimethylbenzene xylene inflammation is evenly smeared on every Mus auris dextra two sides, causes scorching back 1 hour punctual execution animal, card punch with diameter 8mm downcuts ears with the position homalographic, weigh, as the swelling degree, calculate inhibitory rate of intumesce with the difference of two auricle weight.
Table 3 gold seven beautiful aerosol xylol cause mice auricle swelling influence (x ± s, n=10)
Compare with the blank group:
*＜0.05,
*＜0.01, compare with the solvent group:
Experimental result shows: compare with the blank group, gold seven beautiful aerosol height, middle dosage group can significantly suppress the mice auricle swelling due to the dimethylbenzene, and solvent does not have obvious influence to mice auricle swelling; Prompting gold seven beautiful aerosols are that medicine causes to the inhibitory action of inflammation, rather than the solvent generation.
3. analgesic activity
3.1 influence to the reaction of rat water-bath whipping
Get 70 of 180～200g male rats, grouping and administration see Table 4, for three days on end, before the tail administration and after the administration 30,60,120 and 180 minutes, measure whipping response latency of rat respectively in 55 ± 0.5 ℃ of waters bath with thermostatic control, as the pain threshold index.Take the mean and the comparison of blank group, carry out statistical test, the results are shown in Table 4.
The influence that table 4 gold seven beautiful aerosols react rat water-bath whipping (x ± s, n=10)
Compare with matched group:
*P＜0.05,
*P＜0.01, compare with the solvent group:
Experimental result shows: with the blank group relatively, gold seven beautiful aerosol three dosage groups the be significantly increased pain threshold of rat water-bath whipping and rapid-action, long action time.Solvent does not have obviously influence to this reaction; The analgesic activity of prompting gold seven beautiful aerosols is that medicine causes, rather than the solvent generation.
Test conclusion: gold seven beautiful aerosols have remarkable inhibitory action to inductive rat of urate and mice gouty arthritis, can significantly suppress the mice auricle swelling due to the dimethylbenzene, the response time of significant prolongation rat water-bath whipping.
The specific embodiment
Embodiment 1:
Take by weighing 42 parts of iphigenia indicas, 42 parts of stem and leaf of Radix Schefflerae Arboricolae, 42 parts of Folium Craibiodendri Yunnanensiss, 42 parts of Herba Veratri Taliensis, 42 parts of Cortex Phellodendris, 42 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 42 parts of Radix Et Rhizoma Rhei, 6 part of eight flavor of Mentholum medical material in proportion, seven flavors except that Mentholum are ground into coarse powder, mixing, ethanol with 65% floods at twice, each 30 days, merge impregnation liquid, cold preservation 48 hours, filter, collect filtrate, behind the adding Mentholum mixing, medicinal liquid is poured in the clean container, be pressed into third butane gas with pressing machine, promptly get the aerosol for the treatment of gout.
Embodiment 2:
Take by weighing 35 parts of iphigenia indicas, 35 parts of stem and leaf of Radix Schefflerae Arboricolae, 35 parts of Folium Craibiodendri Yunnanensiss, 35 parts of Herba Veratri Taliensis, 35 parts of Cortex Phellodendris, 35 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 35 parts of Radix Et Rhizoma Rhei, 5 part of eight flavor of Mentholum medical material in proportion, seven flavors except that Mentholum are ground into coarse powder, mixing, ethanol with 65% floods at twice, each 30 days, merge impregnation liquid, filter, collect filtrate; Filtrate recycling ethanol, being concentrated into relative density is the thick paste of 1.20～1.25 (50 ℃); Take by weighing an amount of glycerol, add in the above thick paste, make its abundant mixing dissolve, put cold; With 95% dissolve with ethanol Mentholum,, standby with the thick paste mixing that obtains; With the hydrophilic high molecular material is substrate, adds suitable macromolecular material (carbomer, cellulose derivative, sodium alginate etc.) according to routine techniques; Solvent (glycerol, purified water); Nertralizer (triethanolamine, sodium hydroxide); Wetting agent (glycerol, propylene glycol); Percutaneous absorption enhancer (propylene glycol, azone, dimethyl sulfoxide) stirring and evenly mixing.Medical material mixture and the abundant stirring and evenly mixing of substrate are promptly got the gel for the treatment of gout.
Embodiment 3:
Take by weighing 16 parts of iphigenia indicas, 16 parts of stem and leaf of Radix Schefflerae Arboricolae, 16 parts of Folium Craibiodendri Yunnanensiss, 16 parts of Herba Veratri Taliensis, 16 parts of Cortex Phellodendris, 16 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 16 parts of Radix Et Rhizoma Rhei, 2 part of eight flavor of Mentholum medical material in proportion, all the other seven flavor medicine materials except that Mentholum are ground into coarse powder, mixing, ethanol percolation with 65%, flooded 48 hours, percolate is collected in diafiltration, cold preservation 48 hours is filtered; Add Mentholum, mixing, packing promptly gets the liniment for the treatment of gout.
Embodiment 4:
Take by weighing 68 parts of iphigenia indicas, 68 parts of stem and leaf of Radix Schefflerae Arboricolae, 68 parts of Folium Craibiodendri Yunnanensiss, 68 parts of Herba Veratri Taliensis, 68 parts of Cortex Phellodendris, 68 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 68 parts of Radix Et Rhizoma Rhei, 10 part of eight flavor of Mentholum medical material in proportion, seven flavors except that Mentholum are ground into coarse powder, mixing, ethanol with 65% floods at twice, each 30 days, merges impregnation liquid, filter, collect filtrate, with above-mentioned filtrate recycling ethanol, being concentrated into relative density is the thick paste of 1.20～1.25 (50 ℃); Put cold; With 95% dissolve with ethanol Mentholum, with the thick paste mixing that obtains, standby, add suitable adhesive, wetting agent, cross-linking agent, filler as substrate according to routine techniques, prepare burden with the extractum of corresponding proportion recipe quantity, be prepared into rubber cement, after gluing, cutting, lid lining, be cut into segment, packing promptly gets the cataplasma for the treatment of gout.
Claims (2)
1, a kind of externally-applied medicinal composition for the treatment of gout is characterized in that the exterior-applied formulation of being made by following materials of weight proportions: iphigenia indica 16-68 part, stem and leaf of Radix Schefflerae Arboricolae 16-68 part, Folium Craibiodendri Yunnanensis 16-68 part, Herba Veratri Taliensis 16-68 part, Cortex Phellodendri 16-68 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 16-68 part, Radix Et Rhizoma Rhei 16-68 part, Mentholum 2-10 part.
2, the externally-applied medicinal composition of treatment gout according to claim 1 is characterized in that the exterior-applied formulation of being made by following materials of weight proportions medicine: 42 parts of iphigenia indicas, 42 parts of stem and leaf of Radix Schefflerae Arboricolae, 42 parts of Folium Craibiodendri Yunnanensiss, 42 parts of Herba Veratri Taliensis, 42 parts of Cortex Phellodendris, 42 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 42 parts of Radix Et Rhizoma Rhei, 6 parts of Mentholums.
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| CNA200810058822XA CN101337026A (en) | 2008-08-15 | 2008-08-15 | External medicine composition for treating gout |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341135A (en) * | 2013-05-31 | 2013-10-09 | 广州花海药业股份有限公司 | Gel agent for treating arthralgia and preparing method thereof |
| CN108619344A (en) * | 2018-08-13 | 2018-10-09 | 刘元 | Treat the externally applied drug and preparation method thereof of gout |
| JP2021506967A (en) * | 2017-12-15 | 2021-02-22 | マーク、フーパーＭａｒｋ Ｈｏｏｐｅｒ | Dissolution of monosodium urate to treat gout |
-
2008
- 2008-08-15 CN CNA200810058822XA patent/CN101337026A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103341135A (en) * | 2013-05-31 | 2013-10-09 | 广州花海药业股份有限公司 | Gel agent for treating arthralgia and preparing method thereof |
| CN103341135B (en) * | 2013-05-31 | 2015-04-22 | 广州花海药业股份有限公司 | Gel agent for treating arthralgia and preparing method thereof |
| JP2021506967A (en) * | 2017-12-15 | 2021-02-22 | マーク、フーパーＭａｒｋ Ｈｏｏｐｅｒ | Dissolution of monosodium urate to treat gout |
| CN111491625B (en) * | 2017-12-15 | 2023-12-01 | 贺亮 | Dissolving monosodium urate for treating gout |
| CN108619344A (en) * | 2018-08-13 | 2018-10-09 | 刘元 | Treat the externally applied drug and preparation method thereof of gout |
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Open date: 20090107 |