CN100569217C - A kind of preparation method that is used for the skin-care gel of skin pruritus - Google Patents
A kind of preparation method that is used for the skin-care gel of skin pruritus Download PDFInfo
- Publication number
- CN100569217C CN100569217C CNB2006100007896A CN200610000789A CN100569217C CN 100569217 C CN100569217 C CN 100569217C CN B2006100007896 A CNB2006100007896 A CN B2006100007896A CN 200610000789 A CN200610000789 A CN 200610000789A CN 100569217 C CN100569217 C CN 100569217C
- Authority
- CN
- China
- Prior art keywords
- gel
- skin
- ethanol
- collect
- filtering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000003251 Pruritus Diseases 0.000 title claims abstract description 24
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 108
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 75
- 239000007788 liquid Substances 0.000 claims description 51
- 238000003756 stirring Methods 0.000 claims description 36
- 238000001914 filtration Methods 0.000 claims description 34
- 238000002156 mixing Methods 0.000 claims description 34
- 238000005325 percolation Methods 0.000 claims description 34
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 25
- 229920002125 Sokalan® Polymers 0.000 claims description 25
- 229960001631 carbomer Drugs 0.000 claims description 25
- 239000002904 solvent Substances 0.000 claims description 22
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 17
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 8
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 8
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000003814 drug Substances 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 11
- 201000010099 disease Diseases 0.000 abstract description 10
- 201000004624 Dermatitis Diseases 0.000 abstract description 5
- 208000010668 atopic eczema Diseases 0.000 abstract description 5
- 201000009053 Neurodermatitis Diseases 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 3
- 244000045947 parasite Species 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 239000011248 coating agent Substances 0.000 abstract description 2
- 238000000576 coating method Methods 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 230000008569 process Effects 0.000 abstract description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 21
- 239000000796 flavoring agent Substances 0.000 description 13
- 235000019634 flavors Nutrition 0.000 description 13
- 238000001556 precipitation Methods 0.000 description 11
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 8
- 239000002671 adjuvant Substances 0.000 description 8
- 239000004302 potassium sorbate Substances 0.000 description 8
- 235000010241 potassium sorbate Nutrition 0.000 description 8
- 229940069338 potassium sorbate Drugs 0.000 description 8
- 239000000080 wetting agent Substances 0.000 description 8
- 230000002421 anti-septic effect Effects 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 6
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 6
- 229940033663 thimerosal Drugs 0.000 description 6
- 229920002907 Guar gum Polymers 0.000 description 5
- 239000000665 guar gum Substances 0.000 description 5
- 235000010417 guar gum Nutrition 0.000 description 5
- 229960002154 guar gum Drugs 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 239000000230 xanthan gum Substances 0.000 description 5
- 235000010493 xanthan gum Nutrition 0.000 description 5
- 229920001285 xanthan gum Polymers 0.000 description 5
- 229940082509 xanthan gum Drugs 0.000 description 5
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 235000010199 sorbic acid Nutrition 0.000 description 4
- 229940075582 sorbic acid Drugs 0.000 description 4
- 239000004334 sorbic acid Substances 0.000 description 4
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 208000020442 loss of weight Diseases 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 3
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 3
- 229940098465 tincture Drugs 0.000 description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
- 208000035357 Focal Infection Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 241000545442 Radix Species 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 206010040882 skin lesion Diseases 0.000 description 2
- 231100000444 skin lesion Toxicity 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 235000010413 sodium alginate Nutrition 0.000 description 2
- 239000000661 sodium alginate Substances 0.000 description 2
- 229940005550 sodium alginate Drugs 0.000 description 2
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000007848 Alcoholism Diseases 0.000 description 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020852 Hypertonia Diseases 0.000 description 1
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 1
- 206010024438 Lichenification Diseases 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 206010034719 Personality change Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 210000004727 amygdala Anatomy 0.000 description 1
- 230000003260 anti-sepsis Effects 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229960003291 chlorphenamine Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 229960000520 diphenhydramine Drugs 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000001314 paroxysmal effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229960003910 promethazine Drugs 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- -1 tragcanth Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of skin-care gel that is used for skin pruritus and preparation method thereof, belong to technical field of Chinese medicine.It mainly adds proper auxiliary materials by the Radix Stemonae, Herba polygoni hydropiperis, Mentholum and is prepared from, and has skin moistening and itch stopping, and the effect that parasite killing is deodorized is used for diseases such as various skin pruritus, eczema, neurodermatitis.Gel supplementary product kind of the present invention, consumption and principal agent reasonable mixture ratio, feasible process, quality controllable; Gel of the present invention has smooth in appearance, transparent exquisiteness; Local nonirritant does not hinder the normal function of skin; Denseness, viscosity suit, and are easy to coating and use; Carry, transport, preserve advantages such as very convenient.
Description
Technical field
The present invention relates to a kind of skin-care gel that is used for skin pruritus and preparation method thereof, belong to technical field of Chinese medicine.
Technical background
Though skin pruritus performance clinically only has pruritus, there be not significantly former skin lesion, because pruritus often is a paroxysmal, especially with night for very, the person of being in a bad way must not sleep peacefully for a long time because acute pruritus, has neurasthenic symptoms such as dizziness, depressed, inappetence.Eczema, neurodermatitis are very common at department of dermatologry, account for department of dermatologry outpatient's about 50%, and cause of disease complexity, easily repeatedly, belong to one of difficult disease of department of dermatologry.
The common cause of skin pruritus has endocrine disturbance, pruritus hiemalis, hepatorenal disease, malignant tumor, spirituality factor, excessive cleaning skin etc.Neurodermatitis has another name called lichen chronicus simplex, is a kind of mainly to scratch where it itches and lichenification is the chronic dermatosis of feature, the Chang Fanfu outbreak.The primary disease cause of disease is still not exclusively clear and definite.It is generally acknowledged to be due to cerebral cortex excitement and inhibit feature are lacked of proper care. often because of morbidity or aggravations such as anxious state of mind, hypertonicity, neurasthenias.Local excitations such as digestive system disease, dyshormonia, focal infection, alcoholism, medicated clothing friction, Exposure to Sunlight perspiration all can inspire primary disease, aggravate disease.Eczema is a kind of common skin inflammatory reaction disease, and its characteristics are acute stage skin lesion pleomorphism (erythema, pimple, vesicle etc.), the tendency of oozing out are arranged, conscious scratching where it itches; Chronic phase, is often based on lichen sample pathological changes, easily repeatedly.The pathogenic factor complexity of eczema, multiple often internal and external factor interacts and causes a disease, belong to a kind of delayed allergy, stimulating food such as feed fish, shrimp, egg, beef and mutton suck certain pollen, dirt demodicid mite, Pilus Caprae seu Ovis etc., focal infection (amygdala inflammation, dental caries etc.), Enterozoa, the daylight in the living environment, sweltering heat, drying etc., number of chemical materials such as cosmetics, soap, synthetic fibers all can be pathogenic factors.
For the many oral antihistamines of above-mentioned disease doctor trained in Western medicine such as promethazine, chlorphenamine, diphenhydramine, but the drowsiness side effect of Denging is arranged; Corticosteroid hormone such as hydrocortisone ointment agent or cream etc., but easily recurrence after the drug withdrawal can not be effected a radical cure, and dependency and various untoward reaction are arranged after the prolonged application.Because the curative effect of Western medicine is general, taken dependency and various untoward reaction for a long time, and Chinese medicine has unique advantage aspect the disease that cures difficult and complicated cases always, pure Chinese medicinal preparation has been subjected to more patients' favor.Health skin tincture with its good curative effect on market always in occupation of suitable share, it is higher that right because tincture generally contains the alcohol amount, storage, transportation are inconvenient, easily skin being produced in use stimulates, and then makes it be subjected to very big restriction in clinical use.For this reason, develop a kind of determined curative effect, take, storage, convenient transportation, be easier to just to be seemed particularly important by the novel dosage form that extensive patients is accepted.
Gel is one of most active in recent years medicine novel form, is the focus of local topical preparation research and development in recent years, has smooth in appearance, transparent exquisiteness; Nonirritant does not hinder the normal function of skin; Denseness, viscosity suit, and are easy to coating and use, and it is very convenient to carry, use, preserve, transport, advantages such as good stability.For this reason, the inventor has developed a kind of novel gel preparation from the character of medicine itself and the characteristics and the modern requirement of Chinese medicine preparation of surgery local application.By retrieval, this gel still belongs to internal blank.
Summary of the invention
The object of the present invention is to provide a kind of new pharmaceutical preparation and preparation method thereof, this invention preparation mainly adds proper auxiliary materials by the Radix Stemonae, Herba polygoni hydropiperis, Mentholum and is prepared from, have skin moistening and itch stopping, the effect that parasite killing is deodorized is used for skin prurituss such as various skin pruritus, eczema, neurodermatitis.In the side, Radix Stemonae slightly warm in nature, sweet in the mouth, hardship, external has insecticidal action; Herba polygoni hydropiperis acrid in the mouth, warm in nature has dehumidifying, changes the function that stagnates, external treatment skin pruritus; Mentholum acrid in the mouth, cool in nature has effects such as dispelling wind, heat clearing away, detoxifcation, diseases such as external curing skin pruritus due to wind pathogen.Three medicines share plays skin moistening and itch stopping, the effect that parasite killing is deodorized altogether.This medicine is through clinical use, determined curative effect, and nontoxic, side effect.Gel of the present invention is applied in the affected part; no greasy feeling; good with the skin coupling; good absorbing; and can form the very thin protecting film of one deck at pars affecta skin after smearing, have protection and wetting action, and carry, store, transport all more convenient; stability improves greatly simultaneously, and then has obviously improved the curative effect of medicine and patient's facility.
The present invention is achieved through the following technical solutions:
A kind of skin-care gel that is used for skin pruritus is characterized in that, counts by weight percentage, count by weight percentage, it is mainly by health skin percolate 72-85%, Mentholum 0.2%, and substrate 0.2-2%, wetting agent 2-12%, antiseptic 0.1-0.5%, solvent 0.3-25.5% are prepared from.Calculate by weight, health skin percolate mainly is prepared from for 50 parts by 200 parts of the Radixs Stemonae, Herba polygoni hydropiperis.Antiseptic comprises one or more in sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, the thimerosal, substrate comprises one or more in sodium alginate, xanthan gum, guar gum, tragcanth, arabic gum, hydroxypropyl methylcellulose, sodium carboxymethyl cellulose, polyacrylamide, cross linked sodium polyacrylate, Polyethylene Glycol, the carbomer, and wetting agent comprises one or both in glycerol, the propylene glycol; Solvent comprises one or both in water, the Different concentrations of alcohol.
Gel-type vehicle is carbomer preferably, and by weight percentage, the carbomer consumption is at 0.3-0.7%; Wetting agent is glycerol preferably, and by weight percentage, the glycerol consumption is at 3-7%; Antiseptic is ethyl hydroxybenzoate preferably, and solvent is meant 50% ethanol.
A kind of preparation method that is used for the skin-care gel of skin pruritus is:
Calculate by weight, the skin-care gel raw material consists of: 200 parts of the Radixs Stemonae, 50 parts of Herba polygoni hydropiperis.
Skin-care gel of the present invention is preparation like this: the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1-3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, and with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, add Mentholum, gel-type vehicle, wetting agent, antiseptic stir and make dissolving, add solvent to full dose, stir, make gel, promptly.
Specifically, gel is preparation like this:
(1) by weight (part is gram), raw material of the present invention consists of: Radix Stemonae 200g, Herba polygoni hydropiperis 50g, Mentholum 2g;
(2) Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, and mixing is according to the percolation (appendix IO of Chinese Pharmacopoeia version in 2000) under fluid extract and the extractum item, make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1-3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, and with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, add Mentholum, carbomer 5.0g, glycerol 50.0g, ethyl hydroxybenzoate 2.0g stir and make dissolving, add solvent to full dose, stir, make gel, promptly.
At prior art, it is higher that health skin tincture contains the alcohol amount, and storage, transportation are extremely inconvenient, easily skin produced drawbacks such as stimulation in use; Novel gel dosage form has been developed in the characteristics of bound drug character of the present invention and medicine for external use and the modern requirement of Chinese medicine preparation.The present invention is through a large amount of experiments, to gel-type vehicle.Adjuvants such as wetting agent carry out preferably, have carried out systematic research to the consumption of its adjuvant and with relevant nature that medicine is used.The gel smooth in appearance that the present invention makes, transparent exquisiteness; No greasy feeling is applied in the affected part, and is good with the skin coupling, good absorbing, and, have protection and humidification at skin surface formation protecting film, and the part is non-stimulated, does not hinder the normal function of skin, and it is very convenient to preserve, transport, carry.
The inventor finds that in development process kind, the consumption of adjuvant have considerable influence to it, and for this reason, the applicant has carried out a series of experiments, to prove beneficial effect of the present invention.
The experimental example Study on Forming
1, the gel-type vehicle kind is selected
Gel has the branch of aqueous gel and oil-base gel, and aqueous gel is because of its excellent biological compatibility, adhesiveness, no greasy feeling, and easy cleaning, pollution clothes is used more in the external dosage form.The aqueous gel adjuvant has natural polymer subclass such as xanthan gum, guar gum, arabic gum etc., cellulose derivative such as hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (CMC-Na), synthetic macromolecular compound carbomer etc.
Test method: the substrate with above-mentioned usual amounts adds respectively in the percolate earlier, stirs, and the results are shown in Table 1.
Table 1 gel-type vehicle kind is preferably shown
Consumption
The supplementary product kind result
(％)
HPMC 0.9 makes even gel, does not have precipitation and separates out.
Carbomer 0.4 makes even gel, and clarity is better, does not have precipitation and separates out.
CMC-Na 1.0 makes even gel, does not have precipitation and separates out.
Xanthan gum 1.0 makes even gel, does not have precipitation and separates out.
Guar gum 1.0 makes even gel, does not have precipitation and separates out.
Arabic gum 5 makes even gel, does not have precipitation and separates out.
Sodium alginate 5 makes even gel, does not have precipitation and separates out.
Tragcanth 5 makes even gel, does not have precipitation and separates out.
Polyacrylamide 2 makes even gel, does not have precipitation and separates out.
Cross linked sodium polyacrylate 2 makes even gel, does not have precipitation and separates out.
Polyethylene Glycol 4 makes even gel, does not have precipitation and separates out.
Table 1 shows, above-mentioned most adjuvant all can satisfy the preparation requirement substantially, the use that cooperatively interacts of the adjuvant of above usual amounts, wherein any one and/or all the other one or more adjuvants are joined and also can be made even gel when using, but be that the every index of gel made of substrate is all more satisfactory especially with the carbomer, so preferred carbomer is as skin-care gel substrate.
2, carbomer consumption screening
Carbomer is an acrylic copolymer with macromolecule, is great swelling state after aqueous dispersion is neutralized, and by thickening, consumption seldom in gel.In order to make the gel that viscosity is moderate, be fit to external, the carbomer consumption is screened.
Carbomer that will be not commensurability adds in the percolate respectively, stirs result such as table 2.
Table 2 carbomer consumption is preferably shown
Consumption (%) result
0.2 it is rarer to make gel, scribble effect is better.
Be fit to 0.3 make the gel stickiness, easily smear.
Be fit to 0.5 make the gel stickiness, easily smear.
Be fit to 0.7 make the gel stickiness, easily smear.
0.8 it is more sticky to make the gel stickiness, more easily smears.
1.4 it is more sticky to make gel, more easily smears.
2.0 it is more sticky to make gel, scribble effect is better.
According to table 2 result, the consumption of carbomer all can satisfy the preparation requirement substantially at 0.2-2.0%, and carbomer consumption obtained gel when 0.3-0.7% is better.
3, the glycerol consumption is investigated
In order to keep moisture preserving time and the comfortableness of gel on skin, the assurance drug absorption is complete, generally to add wetting agent, wetting agent commonly used has glycerol, propylene glycol etc., through trial test, uses glycerol or propylene glycol or the two mixture and all can play moisture-keeping function, and glycerol can dissolve Carbopol 941, and in gel rubber system, do not influence the dissolubility of ingredient and other adjuvant, therefore select for use glycerol, and consumption is screened as wetting agent.
Get transparent paraffin paper and be cut into a certain size, weigh again after evenly being coated with the last layer skin-care gel after precision is weighed, place respectively at about 25 ℃ and 37 ℃ and take out after 8 hours, weigh, determine the water evaporates situation.The results are shown in Table 3.
Table 3 glycerol consumption is preferably shown
25 ℃ 37 ℃ of glycerol consumptions (%)
2 losss of weight 2.8%.Loss of weight 3.5%.
3 losss of weight, 1.5 losss of weight 1.2
5 losss of weight 1.1%.Loss of weight 1.0%.
7 losss of weight, 1.0 losss of weight 0.8
12 losss of weight 0.5%.Loss of weight 0.9%.
As shown in Table 7, the glycerol consumption can play the moisturizing effect substantially between 2～12%, and consumption can play moisture-keeping function preferably when 3-7%.
According to documents and materials, antiseptic often uses sorbic acid, potassium sorbate, ethyl hydroxybenzoate, benzyl alcohol, thimerosal, consumption can play antisepsis when 0.1-0.5%, through trial test, gel of the present invention adopts single or compound antiseptic antiseptic effect when this consumption good.
Experimental example 2: preparation stabilization Journal of Sex Research
Be to investigate the stability of preparation process, the gel fill in aluminium collapsible tube, was placed 40 ℃, the climatic chamber of relative humidity 75% 1 month, character changes before and after the viewing test.The results are shown in Table 4.
Table 4 preparation stability investigation table
The sample appearance character
Orange-yellow clear gel before the test, viscosity is moderate
The orange-yellow clear gel in test back, viscosity is moderate
Accelerated test shows before and after this medicine test does not have significant change in appearance color, physical behavior, illustrates that this medicine is basicly stable, and technology is reasonable.
Concrete embodiment
Embodiment 1: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 850g, add Mentholum, carbomer 5.0g, glycerol 50.0g, ethyl hydroxybenzoate 2.0g, stirring makes dissolving, adds distilled water 91g to full dose, stirs, make gel 1000g, promptly.
Embodiment 2: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 720g, add Mentholum, carbomer 2.0g, glycerol 20.0g, sorbic acid 1.0g, stirring makes dissolving, adds 50% ethanol 255g to full dose, stirs, make gel 1000g, promptly.
Embodiment 3: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 795g, add Mentholum, carbomer 8.0g, glycerol 100.0g, ethyl hydroxybenzoate 1.0g, benzyl alcohol 2.0g stirs and makes dissolving, add 75% ethanol 92g to full dose, stir, make gel 1000g, promptly.
Embodiment 4: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 822g, adds Mentholum, xanthan gum 2.0g, guar gum 3.0g, glycerol 20.0g, propylene glycol 10.0g, sorbic acid 1.0g, thimerosal 1.0g, benzyl alcohol 2g stirs and makes dissolving, adds 80% ethanol 137g to full dose, stirs, make gel 1000g, promptly.
Embodiment 5: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, heavy 780g, add Mentholum, hydroxypropyl methylcellulose 1.0g, sodium carboxymethyl cellulose 4.0g, glycerol 80.0g, potassium sorbate 1.5g stirs and makes dissolving, add distilled water 131.5g to full dose, stir, make gel 1000g, promptly.
Embodiment 6: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 840g, add Mentholum, xanthan gum 2.0g, guar gum 3.0g, glycerol 107.0g, propylene glycol 10.0g, potassium sorbate 2.0g stirs and makes dissolving, add distilled water 34g to full dose, stir, make gel 1000g, promptly.
Embodiment 7: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 788g, add Mentholum, cross linked sodium polyacrylate 20.0g, propylene glycol 50.0g, ethyl hydroxybenzoate 3.0g stirs and makes dissolving, add distilled water 137g to full dose, stir, make gel 1000g, promptly.
Embodiment 8: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 850g, add Mentholum, carbomer 20.0g, glycerol 120.0g, potassium sorbate 5.0g, stirring makes dissolving, adds 50% ethanol 3g to full dose, stirs, make gel 1000g, promptly.
Embodiment 9: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 820g, add Mentholum, carbomer 15.0g, propylene glycol 110.0g, potassium sorbate 4.0g, stirring makes dissolving, adds distilled water 48g to full dose, stirs, make gel 1000g, promptly.
Embodiment 10: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 840g, add Mentholum, carbomer 5.0g, glycerol 50.0g, benzyl alcohol 5.0g, stirring makes dissolving, adds 50% ethanol 98g to full dose, stirs, make gel 1000g, promptly.
Embodiment 11: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, and weight is 810g, add Mentholum, carbomer 3.0g, glycerol 30.0g, thimerosal 5.0g, stirring makes dissolving, adds 50% ethanol 150g to full dose, stirs, make gel 1000g, promptly.
Embodiment 12: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 790g, adds Mentholum, carbomer 7.0g, glycerol 70.0g, thimerosal 2.0g, potassium sorbate 0.5, benzyl alcohol 0.5g, stirring makes dissolving, adds 50% ethanol 128g to full dose, stirs, make gel 1000g, promptly.
Embodiment 13: Radix Stemonae 200g Herba polygoni hydropiperis 50g Mentholum 2g
More than three the flavor, the Radix Stemonae, Herba polygoni hydropiperis are ground into coarse powder, mixing, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, and reclaims ethanol and is concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, weight is 810g, adds Mentholum, hydroxypropyl methylcellulose 7.0g, glycerol 70.0g, thimerosal 2.0g, potassium sorbate 0.5, benzyl alcohol 0.5g, stirring makes dissolving, adds 50% ethanol 128g to full dose, stirs, make gel 1000g, promptly.
Claims (2)
1, a kind of preparation method that is used for the skin-care gel of skin pruritus is characterized in that, described gel is preparation like this:
Radix Stemonae 200g, Herba polygoni hydropiperis 50g are ground into coarse powder, and mixing is according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2000 and the extractum item, make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, adds Mentholum 2g, carbomer 5.0g, glycerol 50.0g, ethyl hydroxybenzoate 2.0g, stirs and makes dissolving, add distilled water to full dose, stir, make gel 1000g, promptly.
2, a kind of preparation method that is used for the skin-care gel of skin pruritus is characterized in that, described gel is preparation like this:
Radix Stemonae 200g, Herba polygoni hydropiperis 50g are ground into coarse powder, and mixing is according to the percolation under Chinese Pharmacopoeia version appendix IO fluid extract in 2000 and the extractum item, make solvent with 75% ethanol, flooded 24 hours, with the speed percolation of per minute 1～3ml, collect the liquid 850ml that just filters, device is preserved in addition; It is colourless to effluent to collect the continuous liquid of filtering, reclaim ethanol and be concentrated into the thick paste shape, with the liquid mixing of just filtering, it is 50% that adjusting contains the alcohol amount, adds Mentholum 2g, carbomer 5.0g, glycerol 50.0g, benzyl alcohol 5.0g, stirs and makes dissolving, add 50% ethanol to full dose, stir, make gel 1000g, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100007896A CN100569217C (en) | 2006-01-11 | 2006-01-11 | A kind of preparation method that is used for the skin-care gel of skin pruritus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100007896A CN100569217C (en) | 2006-01-11 | 2006-01-11 | A kind of preparation method that is used for the skin-care gel of skin pruritus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1833715A CN1833715A (en) | 2006-09-20 |
| CN100569217C true CN100569217C (en) | 2009-12-16 |
Family
ID=37001705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100007896A Expired - Fee Related CN100569217C (en) | 2006-01-11 | 2006-01-11 | A kind of preparation method that is used for the skin-care gel of skin pruritus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100569217C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101332244B (en) * | 2008-06-06 | 2011-12-21 | 叶志军 | Oral traditional Chinese medicine for treating diffused neurodermatitis |
| CN103223110B (en) * | 2013-04-30 | 2014-08-06 | 赵彦梅 | External traditional Chinese medicine composition for treating female pruritus vulvae and preparation method thereof |
| CN106138190B (en) * | 2016-08-08 | 2020-03-31 | 浙江奕箔生物科技有限公司 | External gel preparation, preparation method and application thereof |
| CN106620445B (en) * | 2016-11-09 | 2020-01-03 | 安徽安科余良卿药业有限公司 | Skin-care microemulsion gel and preparation method thereof |
-
2006
- 2006-01-11 CN CNB2006100007896A patent/CN100569217C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 卫生部部颁药品标准中药成方制剂第14册. 卫生部药典委员会，158. 1997 |
| 卫生部部颁药品标准中药成方制剂第14册. 卫生部药典委员会，158. 1997 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1833715A (en) | 2006-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100542585C (en) | A kind of externally-applied medicinal composition with analgesia and antiinflammatory action | |
| CN103041173A (en) | Traditional Chinese medicine external preparation for curing dermatitis and eczema and preparing method thereof | |
| EP1814564B1 (en) | Transmucosal oral delivery device | |
| CN101862400A (en) | Dehumidifying itching-relieving gels and preparation method thereof | |
| CN104013712B (en) | Chinese medicine composition for the treatment of dermatitis and eczema of infants and its preparation method and application | |
| CN106138190B (en) | External gel preparation, preparation method and application thereof | |
| CN1833649A (en) | Jixuedai gel with action of promoting wound reunion, and prepn. thereof | |
| CN101596249B (en) | Chinese medicinal composition and Chinese medicament for treating diarrhea and preparation method thereof | |
| CN100569217C (en) | A kind of preparation method that is used for the skin-care gel of skin pruritus | |
| CN1840051B (en) | Pain-stopping gel with musk and its preparation method | |
| CN105833278B (en) | For treating the composition of xerostomia and mouth disease | |
| CN101278948B (en) | Biological medical membrane and method of preparing the same | |
| CN101053549A (en) | Spot-removing cream | |
| CN107198721A (en) | A kind of compound phellodendron bark gel and preparation method for treating childhood eczema | |
| CN103239586A (en) | Flavored agastache turbidity-dispelling external preparation as well as preparation method and application thereof | |
| CN1840129B (en) | Gel for treating gynecological disease and preparation method thereof | |
| WO2010105448A1 (en) | A chinese medicinal composition for external use in treatment and health care of renal function and its use in manufacture of cataplasm | |
| CN102793830A (en) | Pronephrium triphyllum-rheum officinale gel and preparation method thereof | |
| CN1833693A (en) | Red medicine gel for treating traumatic injury and its prepn. method | |
| CN101485779B (en) | Medicinal composition for treating psoriasis as well as preparation method and quality detection method | |
| CN101032553B (en) | Chinese traditional medicine for curing stomatocace and its producing method | |
| JP5265347B2 (en) | Use of konjac and its extract in formulating pharmaceuticals for the treatment of acute and chronic bronchitis | |
| CN102688330A (en) | Biological Chinese medicine film and preparation method thereof | |
| CN103083520B (en) | Traditional Chinese cataplasm for traumatic injury as well as preparation method thereof | |
| CN104434992A (en) | Biological adhesive vaginal tablet of periplaneta americana extract and preparation method of biological adhesive vaginal tablet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003 Patentee after: Beijing Ying Kerui Biological Medicine Research Co.,Ltd. Address before: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003 Patentee before: Beijing Yinkeruisi Biological Medicine Research Co.,Ltd. Address after: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003 Patentee after: Beijing Yinkeruisi Biological Medicine Research Co.,Ltd. Address before: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003 Patentee before: Beijing Increase Biological Products Research Institute |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170504 Address after: 102209 Beijing city Changping District town Beiqijia Hongfu building room 1009 Patentee after: BEIJING INCREASE PHARMACEUTICAL INSTITUTE Co.,Ltd. Address before: 100088 Beijing city Xicheng District, New Street No. 2 Tiancheng Technology building block B room 3003 Patentee before: Beijing Ying Kerui Biological Medicine Research Co.,Ltd. |
|
| CP03 | Change of name, title or address |
Address after: Double camp 102200 West Road Beijing city Changping District Science Park No. 79, No. 24 building 6 layer cloud Valley Park Patentee after: Beijing Increasepharm Co.,Ltd. Address before: 102209 Beijing city Changping District town Beiqijia Hongfu building room 1009 Patentee before: BEIJING INCREASE PHARMACEUTICAL INSTITUTE Co.,Ltd. |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20190621 Address after: 262513 No. 3787 New York Road, Qingzhou Economic Development Zone, Weifang City, Shandong Province Patentee after: QINGZHOU YAOWANG PHARMACEUTICAL Co.,Ltd. Address before: 102200 Beijing Changping Science and Technology Park Shuangying West Road 79 Courtyard Yunguyuan 24 Floor 6 Patentee before: Beijing Increasepharm Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190726 Address after: Unit 501C, C19 Floor, 218 Xinghu Street, Suzhou Industrial Park, Jiangsu Province Patentee after: Suzhou Gongzheng Biomedical Technology Co.,Ltd. Address before: 262513 No. 3787 New York Road, Qingzhou Economic Development Zone, Weifang City, Shandong Province Patentee before: QINGZHOU YAOWANG PHARMACEUTICAL Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20200922 Address after: 262513 No. 3787 New York Road, Qingzhou Economic Development Zone, Weifang City, Shandong Province Patentee after: QINGZHOU YAOWANG PHARMACEUTICAL Co.,Ltd. Address before: Unit 501C, C19 Floor, 218 Xinghu Street, Suzhou Industrial Park, Jiangsu Province Patentee before: Suzhou Gongzheng Biomedical Technology Co.,Ltd. |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091216 Termination date: 20210111 |