CN1931181A - New use of tremella heteropolysaccharide or its extract - Google Patents
New use of tremella heteropolysaccharide or its extract Download PDFInfo
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- CN1931181A CN1931181A CNA2005100297466A CN200510029746A CN1931181A CN 1931181 A CN1931181 A CN 1931181A CN A2005100297466 A CNA2005100297466 A CN A2005100297466A CN 200510029746 A CN200510029746 A CN 200510029746A CN 1931181 A CN1931181 A CN 1931181A
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- white fungus
- extract
- fungus heteropolysaccharideand
- capsule
- tremella
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Abstract
The present invention discloses the use of tremella heteropolysaccharide or its extract in preparing medicine, food, beverage and health product for protecting or repairing gastric mucous membrane.
Description
Technical field
The present invention relates to a kind of purposes of heteropolysaccharide, relate in particular to a kind of white fungus heteropolysaccharideand or its extract purposes in protection or gastric mucosa reparation.
Background technology
Tremella (Tremella faciformis Berk) claims Tremella, Mulberry goose, " clear different record " again.Belong to Tremellales (Tremellales), Tremellaceae (Tremellacease), Tremella (Tremella).Effect with nourishing YIN and moistening the lung, QI invigorating and blood regulating.White fungus heteropolysaccharideand is a kind of acid heteroglycan of extraction separation from Tremella fructification (or its microbial fermentation solution).China is referred to as Tremella senior tonic and medicine since ancient times, and the good merchantable brand of medicine-food two-purpose is the first-class food of nourishing in imperial palace.
Along with the continuous development of science and the continuous lifting of technological means, people have had understanding again to Tremella, both at home and abroad to Tremella main component---white fungus heteropolysaccharideand has carried out a large amount of research, show that white fungus heteropolysaccharideand has pharmacological actions such as the immunity of raising, antitumor, defying age, blood sugar lowering, blood fat, promotion protein nucleic acid are synthetic, antithrombotic.Japan applies to it in health product, cosmetics, the medicine widely.The Application and Development of Tremella has caused the very big interest of scientific circles, is subjected to the extensive attention of international the world of medicine and cosmetic field, becomes the hot issue of current research and development.
But up to now, the The Nomenclature Composition and Structure of Complexes of white fungus heteropolysaccharideand and corresponding function but seldom have report.The applicant uses special separation purifying technique that active polysaccharide in the Tremella is refined, detect evaluation through modern analytical technique, the structure of this white fungus heteropolysaccharideand is so that α-(1-3) mannose is a main chain, is that neutral total sugar, the glucuronic acid of 6-28%, the conjugated protein of 0.1-3% of 70-93% formed by percentage by weight mainly; The mean molecule quantity of this white fungus heteropolysaccharideand is 85-160 ten thousand dalton, wherein molecular weight is greater than 6000 daltonian accounting for more than 90% (weight), specifically the application number of applying on January 18th, 2005 referring to the applicant is 200510023427.4 patent application, and with its trade name called after WSK; This patent application also discloses white fungus heteropolysaccharideand and extract thereof and has had functions such as preserve moisture lubricious skin and mucosa, the lubricated sense of enhancing, oxidation-resisting and caducity, antiallergic, thick stabilization.Up to the present, also there is not white fungus heteropolysaccharideand to have the relevant report of protection gastric mucosa.
Summary of the invention
The objective of the invention is for a kind of application number is provided is the white fungus heteropolysaccharideand of the commodity WSK by name in 200510023427.4 the patent application or the new purposes of white fungus heteropolysaccharideand extract, and this new purposes is white fungus heteropolysaccharideand or the purposes of white fungus heteropolysaccharideand extract in medicine, diet product or the health product of preparation protection or gastric mucosa reparation.
The structure of white fungus heteropolysaccharideand of the present invention is so that α-(1-3) mannose is a main chain, is that neutral total sugar, the glucuronic acid of 6-28%, the conjugated protein of 0.1-3% of 70-93% formed by percentage by weight mainly; The mean molecule quantity of this white fungus heteropolysaccharideand is 85-160 ten thousand dalton, and wherein molecular weight is greater than 6000 daltonian accounting for more than 90% (weight).Wherein, described neutral total sugar mainly comprises the glycosyl of following content: 35-60% mannose, 10-25% fucose, 8-18% xylose and 5-15% glucose, above-mentioned content are in white fungus heteropolysaccharideand weight.
The side chain of this white fungus heteropolysaccharideand has multiple different variations combination, and a kind of combination wherein is determined as the construction unit shown in the following structural formula I by the X-ray diffraction method:
The molecular weight of this construction unit is 2578.5 or 2724.7.This sugar structure is so that α-(1-3) mannose (Manp) is a main chain backbone, is connected with the xylose (Xylp) of 2 β-(1-2) on its 2 carbon atoms, 3 beta-glucuronic acids (GlcAp), and 1 or 2 fucose (Fuc), 1 mannose is a side chain.
White fungus heteropolysaccharideand extract of the present invention comprises that mainly percentage by weight is the above-mentioned white fungus heteropolysaccharideand of 80-98%, the floating preteins of 0.1-3.3% and the ash of 0.5-8%; The mean molecule quantity of this white fungus heteropolysaccharideand extract is 75-140 ten thousand dalton, and wherein molecular weight is greater than the 6000 daltonian 75-98% (weight) that account for.
White fungus heteropolysaccharideand preparation method of extract of the present invention comprises the steps:
1) with Tremella fructification raw material water 80-100 ℃ stir down extract crude extract;
2) crude extract with the step 1) gained filters, and filtrate finally is the filter of 0.1-1 μ m by the aperture;
3) in step 2) add ethanol in the filtrate of gained, making alcoholic acid final volume concentration is 50-85%, collecting precipitation;
4) with the precipitation drying of step 3) gained.
Wherein, this Tremella fructification raw material is exsiccant Tremella fructification raw material, should be soaked in water, expand and clean up (comprising the yellowish-brown base portion) by exsiccant Tremella fructification raw material, at every turn with 20-100 doubly, be no more than when multiple extraction 200 times (weight) in the water of this exsiccant Tremella fructification material quantity 80-100 ℃ stir down extract crude extract.
This Tremella fructification raw material also can be the fresh Tremella fructification raw material or the refrigerated fresh Tremella fructification raw material of fresh Tremella fructification raw material, fresh-keeping and cold storage, this Tremella fructification raw material removed the yellowish-brown base portion and clean up, at every turn with 2-15 doubly, be no more than when multiple extraction 30 times (weight) in the water of this Tremella fructification material quantity 80-100 ℃ stir down extract crude extract.
The another kind of preparation method of white fungus heteropolysaccharideand extract of the present invention comprises the steps:
1) will (list of references is Tremella submerged fermentation Study on Conditions 1., Wu Dakang etc. according to conventional microbial fermentation processes; Food Science; 2002, Vol.23, No.1; 64; 2. the research of Tremella bacterium separation method, ZhangBing Chi; Edible fungi of china; Vol.13, No.3; 22) the Tremella fermentation liquid of Huo Deing was heated to 80-100 ℃, insulation 0.5-2 hour, filtered, and clear liquid is that the filter of 0.1-1 μ m gets filtrate by the aperture finally;
2) add ethanol in the filtrate of step 1) gained, making ethanol final volume concentration is 50-85%, collecting precipitation;
3) with step 2) precipitation of gained carries out drying.
The preparation method of white fungus heteropolysaccharideand of the present invention comprises the step that the extract that will adopt above-mentioned preparation method to make is further purified.
Wherein, this purification adopts Sevag method and dialysis to realize.Certainly, as is known to the person skilled in the art, other polysaccharide purification method also can make white fungus heteropolysaccharideand of the present invention as chromatography etc.
Described medicine can be a various dosage form of the prior art, as powder, tablet, capsule (comprising soft capsule and hard capsule), liquid agent, suspension, Emulsion, oral liquid, fruit jelly or electuary.
Described diet product comprise beverage and food, be the concentrated solution that contains white fungus heteropolysaccharideand or white fungus heteropolysaccharideand extract and/or the beverage or the food of dry thing, to the application of diet product without limits, can be various dosage form of the prior art, as using in powder, tablet, capsule (comprising soft capsule and hard capsule), granule, electuary, fruit jelly, beverage, milk product or biscuit baked goods etc.
Described health product can be various dosage forms of the prior art, as powder, tablet, capsule (comprising soft capsule and hard capsule), liquid agent, suspension, Emulsion, oral liquid, fruit jelly or electuary etc.
According to the present invention, can also contain the medicine of other protections or gastric mucosa reparation in the described medicine, this white fungus heteropolysaccharideand can play the effect of auxiliary protection or gastric mucosa reparation.The medicine of these other protections or gastric mucosa reparation can be: as nabumetone, it can suppress the gastric mucosa neutrophilic granulocyte activation.
Can also contain other various edible nutritional labelings in described diet product or the health product, to play the effect of better nourishing healthy.
Described white fungus heteropolysaccharideand can be the white fungus heteropolysaccharideand crude product of slightly carrying that contains impurity, also can be the pure product of white fungus heteropolysaccharideand.
Described protection gastric mucosa is meant and prevents that gastric mucosa is impaired or alleviate the impaired degree of gastric mucosa.Described gastric mucosa reparation is meant repairs impaired gastric mucosa, so that impaired gastric mucosa returns to the normal healthy state.In the process of gastric mucosa reparation, gastric epithelial cells regeneration, defense function is enhanced, and the ability of resisting virulence factor is improved, and the barrier ability of gastric mucosa is enhanced.
The specific embodiment
Be that preparation method in 200510023427.4 the patent application prepares required white fungus heteropolysaccharideand extract and white fungus heteropolysaccharideand (WSK) now, it be described in detail as follows according to the applicant's application number:
Embodiment 1
Exsiccant Tremella fructification is soaked in water, after the expansion, removes its yellowish-brown base portion and clean up; Raw material after cleaning is put into extraction pot, add 100 times of water to siccative, stir under 100 ℃ of water temperatures and extract 4h, filter then, clear liquid finally is the filter of 0.1-1 μ m by the aperture; Evenly stir down, cleaner liquid and ethanol are fully mixed, making the ethanol ultimate density in the mixing material is 85%, and collecting precipitation is with straight alcohol dehydration, collecting precipitation;-40 ℃ of lyophilizations, pulverize the white fungus heteropolysaccharideand extract.Product yield 20% (in dry tremella weight).
Embodiment 2
With the Tremella of fresh-keeping and cold storage, remove its yellowish-brown base portion and clean up; Raw material after cleaning is put into extraction pot, add 15 times of water to the aquatic foods material, stir under 100 ℃ of water temperatures and extract 4h, filter then, clear liquid finally is the filter of 0.1-1 μ m by the aperture; The cleaner liquid heating concentrates, and gets concentrated solution; Evenly stir down, cleaner liquid and ethanol are fully mixed, making the ethanol ultimate density in the mixing material is 85%, and collecting precipitation is used the straight alcohol dehydration and decolorization, collecting precipitation; 80 ℃ of hot air dryings, pulverize the white fungus heteropolysaccharideand extract.Product yield 2.1% (in bright Tremella weight).
Embodiment 3
With the Tremella fermentation liquid that microbial fermentation obtains, heat 100 ℃, 0.5h, conventional filtration is abandoned filtering residue, and clear liquid finally is the filter of 0.1-1 μ m by the aperture; Evenly stir down, cleaner liquid and ethanol are fully mixed, making the ethanol ultimate density in the mixing material is 85%, and collecting precipitation is with 100% ethanol dehydration decolouring, collecting precipitation;-40 ℃ of lyophilizations, pulverize the white fungus heteropolysaccharideand extract.Product yield 0.55% (in fermentation liquid weight).
Embodiment 4
The white fungus heteropolysaccharideand extract of embodiment 1～3 with 600 times of (weight) deionized water dissolving, after the dissolving, is added the chloroform of 200mL: the mixed solution of n-butyl alcohol=4: 1 (volume ratio), after fully mixing, with centrifuge centrifugal (4000r/min, 30 minutes), collect supernatant.Supernatant after centrifugal is mixed by 3: 1 (volume ratio) with above-mentioned chloroform n-butyl alcohol mixed solution, and, collect supernatant with centrifuge centrifugal (4000r/min, 30 minutes).Repeat above operation, repeated treatments to water till the OD at 280nm place value (using 752 ultraviolet grating spectrophotometers, Shanghai exact science instrument plant) no longer descends.Water is evaporated to 1/3rd, and concentrated solution fully mixes with 95% ethanol of 3 times of amounts of water (volume ratio), and centrifugal 30 minutes of 4000r/min gets precipitate.Precipitate with 100 times of (weight) deionized water dissolving after, centrifugal, remove insoluble matter, clear liquid is packed in the long bag filter of 30cm (bag filter can by the following material of 5000 molecular weight) dialyse (two tie hang be incorporated with deionized water bottle in, and use deionized water flowing water to wash 12 hours), collect the above material of 5000 molecular weight.Clear liquid after dialysis fully mixes with 3 times of amounts (volume) straight alcohol, and 4000r/min is centrifugal 30 minutes once more, gets precipitate, and after precipitate dewatered with dehydrated alcohol, 60 ℃ of vacuum dryings obtained fine silver ear heteropolysaccharide (WSK).
The damage of effect embodiment 1 white fungus heteropolysaccharideand (WSK) protection gastric mucosa
The white fungus heteropolysaccharideand that sample: embodiment 4 obtains (WSK) by the adult of 60 kilograms of body weight, recommends a day dosing to be: 0.8% (w/w) white fungus heteropolysaccharideand solution, 200mL/ people, every day 2 times.Rat according to 10 times of 0.8% (w/w) white fungus heteropolysaccharideands to people's dosage, i.e. 6.6mL/200 gram, twice of every day.
Animal: in 9 ages in week of cleaning level male rat, body weight 200 ± 10 grams are provided certificate of competency SCXR (Shanghai) 2000-0002 by the department of the Chinese Academy of Sciences of laboratory animal section of Fudan University.
Animal Lab.: cleaning level barrier unit, certificate of competency 02-1-2,23 ℃ ± 0.5 ℃ of room temperature, humidity 70% ± 5%.
Instrument and reagent: dissecting instrument, slide gauge, ethanol.
Animal is tried the thing route of administration: each dosage is the 6.6mL/ rat, irritates stomach at twice.
Experimental technique: white fungus heteropolysaccharideand is to the influence of the rat gastric mucosal protection of gastric mucosa acute alcohol damage
10 rats of experimental group gave 0.8% (w/w) white fungus heteropolysaccharideand solution (irritating stomach every day 2 times) in continuous 10 days, irritated in stomach by the oral cavity with irrigation stomach device; 10 days (irritating 2 equivalent distilled water of stomach every day) of 10 of matched group normal raisings of rat dissected preceding rat fasting (can't help water) 24 hours in addition.The same day, experimental group was irritated stomach 0.8% (w/w) white fungus heteropolysaccharideand 5 multiple doses (3.3mL), and matched group was irritated stomach equivalent distilled water the same day; After 1 hour, irritate stomach dehydrated alcohol (dosage is the 1.0mL/ Mus) again; After 1 hour, put to death animal; Get stomach fixing immersion in 10% formaldehyde; After 20 minutes, cut off, remove gastric content, gastric mucosa is launched, go out to measure the area (being accurate to 0.01mm) of hyperemia or diffuse hemorrhage band with slide gauge along greater gastric curvature.With the gross area of hyperemia band and diffuse hemorrhage band evaluation index as degree of injury.
Date processing: all data are all represented with x ± S, adopt t check analysis significance between group.Experimental result sees Table 1.
The gross area table of table 1 rat gastric mucosa congestion band and diffuse hemorrhage band
| Group | Number (only) | The gross area (the mm of congested band and diffuse hemorrhage band 2) |
| The matched group experimental group | 10 10 | 5.41±1.53 3.23±1.49★ |
After the administration 10 days, the gross area of experimental group rat gastric mucosa congestion band and diffuse hemorrhage band is less than matched group, and the hyperemia band of experimental group rat and the gross area of diffuse hemorrhage band are 3.23 ± 1.49mm
2, with respect to control rats (5.41 ± 1.53mm
2) have a significant difference, P＜0.05 (t check).
Conclusion: white fungus heteropolysaccharideand extract and white fungus heteropolysaccharideand (WSK) have prevention and a defencive function to gastric mucosa is impaired, and as to the acute impaired defencive function that has of gastric mucosa, especially damage has assistant protection function preferably to the gastric mucosa acute alcohol.
Claims (2)
1, a kind of white fungus heteropolysaccharideand or the white fungus heteropolysaccharideand extract purposes in medicine, diet product or the health product of preparation protection or gastric mucosa reparation.
2, purposes according to claim 1 is characterized in that described medicine is powder, tablet, capsule (comprising soft capsule and hard capsule), liquid agent, suspension, Emulsion, oral liquid, fruit jelly or electuary; Described diet product are for containing the concentrated solution of white fungus heteropolysaccharideand or white fungus heteropolysaccharideand extract and/or the beverage or the food of dry thing, to the application of diet product without limits, can use in powder, tablet, capsule (comprising soft capsule and hard capsule), granule, electuary, fruit jelly, beverage, milk product or biscuit baked goods etc.; Described health product are powder, tablet, capsule (comprising soft capsule and hard capsule), liquid agent, suspension, Emulsion, oral liquid, fruit jelly or electuary.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100297466A CN100490821C (en) | 2005-09-16 | 2005-09-16 | New use of tremella heteropolysaccharide or its extract |
| PCT/CN2005/001573 WO2007030974A1 (en) | 2005-09-16 | 2005-09-26 | New usage of tremella fuciformis heteropolysaccharide or extract thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100297466A CN100490821C (en) | 2005-09-16 | 2005-09-16 | New use of tremella heteropolysaccharide or its extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1931181A true CN1931181A (en) | 2007-03-21 |
| CN100490821C CN100490821C (en) | 2009-05-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100297466A Active CN100490821C (en) | 2005-09-16 | 2005-09-16 | New use of tremella heteropolysaccharide or its extract |
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| CN (1) | CN100490821C (en) |
| WO (1) | WO2007030974A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102161710A (en) * | 2011-05-16 | 2011-08-24 | 高其品 | Method for preparing tremellan with low molecular weight and novel medicinal application thereof |
| CN102219932A (en) * | 2011-05-06 | 2011-10-19 | 齐齐哈尔大学 | Preparation method of edible soup bases packaging film containing tremellan |
| CN102499407A (en) * | 2011-11-15 | 2012-06-20 | 北川丰煜食品综合加工进出口有限公司 | Actinidia drink and preparation method thereof |
| CN108968074A (en) * | 2018-06-06 | 2018-12-11 | 福建省农业科学院农业工程技术研究所 | A kind of tremella alditol acid polysaccharide-Fu-Rong plums anthocyanidin compound of segmented intestine targeted delivering and preparation method thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103819571B (en) * | 2013-12-20 | 2016-08-17 | 中华全国供销合作总社南京野生植物综合利用研究所 | A kind of Tremella fructification polysaccharide technology of preparing |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1293101C (en) * | 2002-11-27 | 2007-01-03 | 高其品 | White fungus polysaccharide and its preparation method as well as medicament composition with the compound as active constituent |
-
2005
- 2005-09-16 CN CNB2005100297466A patent/CN100490821C/en active Active
- 2005-09-26 WO PCT/CN2005/001573 patent/WO2007030974A1/en active Application Filing
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102219932A (en) * | 2011-05-06 | 2011-10-19 | 齐齐哈尔大学 | Preparation method of edible soup bases packaging film containing tremellan |
| CN102219932B (en) * | 2011-05-06 | 2013-06-12 | 齐齐哈尔大学 | Preparation method of edible soup bases packaging film containing tremellan |
| CN102161710A (en) * | 2011-05-16 | 2011-08-24 | 高其品 | Method for preparing tremellan with low molecular weight and novel medicinal application thereof |
| CN102499407A (en) * | 2011-11-15 | 2012-06-20 | 北川丰煜食品综合加工进出口有限公司 | Actinidia drink and preparation method thereof |
| CN108968074A (en) * | 2018-06-06 | 2018-12-11 | 福建省农业科学院农业工程技术研究所 | A kind of tremella alditol acid polysaccharide-Fu-Rong plums anthocyanidin compound of segmented intestine targeted delivering and preparation method thereof |
| CN108968074B (en) * | 2018-06-06 | 2021-09-28 | 福建省农业科学院农业工程技术研究所 | Tremella uronic acid polysaccharide-hibiscus plum anthocyanin compound for colon-targeted delivery and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100490821C (en) | 2009-05-27 |
| WO2007030974A1 (en) | 2007-03-22 |
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