CN112006938A - Damaged skin repairing gel and preparation process thereof - Google Patents
Damaged skin repairing gel and preparation process thereof Download PDFInfo
- Publication number
- CN112006938A CN112006938A CN202010923922.5A CN202010923922A CN112006938A CN 112006938 A CN112006938 A CN 112006938A CN 202010923922 A CN202010923922 A CN 202010923922A CN 112006938 A CN112006938 A CN 112006938A
- Authority
- CN
- China
- Prior art keywords
- phase
- component
- stirring
- cooling
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title description 8
- 238000001879 gelation Methods 0.000 title description 2
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 48
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims abstract description 16
- NDVLTYZPCACLMA-UHFFFAOYSA-N silver oxide Chemical compound [O-2].[Ag+].[Ag+] NDVLTYZPCACLMA-UHFFFAOYSA-N 0.000 claims abstract description 16
- VEUACKUBDLVUAC-UHFFFAOYSA-N [Na].[Ca] Chemical compound [Na].[Ca] VEUACKUBDLVUAC-UHFFFAOYSA-N 0.000 claims abstract description 13
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 claims abstract description 12
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 claims abstract description 12
- 229940022757 asiaticoside Drugs 0.000 claims abstract description 12
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims abstract description 12
- -1 glycerol glucoside Chemical class 0.000 claims abstract description 10
- JXSVIVRDWWRQRT-UYDOISQJSA-N asiatic acid Chemical compound C1[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C JXSVIVRDWWRQRT-UYDOISQJSA-N 0.000 claims abstract description 9
- 229940011658 asiatic acid Drugs 0.000 claims abstract description 9
- LBGFKBYMNRAMFC-PYSQTNCISA-N asiatic acid Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@@]34C)[C@]2(C)[C@H]1C)C(=O)O LBGFKBYMNRAMFC-PYSQTNCISA-N 0.000 claims abstract description 9
- CLXOLTFMHAXJST-UHFFFAOYSA-N esculentic acid Natural products C12CC=C3C4CC(C)(C(O)=O)CCC4(C(O)=O)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(CO)C CLXOLTFMHAXJST-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229930182478 glucoside Natural products 0.000 claims abstract description 9
- 229940015975 1,2-hexanediol Drugs 0.000 claims abstract description 8
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 8
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims abstract description 8
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims abstract description 8
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 8
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims abstract description 8
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims abstract description 8
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960000458 allantoin Drugs 0.000 claims abstract description 8
- 229920006037 cross link polymer Polymers 0.000 claims abstract description 8
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims abstract description 8
- 150000002148 esters Chemical class 0.000 claims abstract description 8
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims abstract description 8
- PRAUVHZJPXOEIF-AOLYGAPISA-N madecassic acid Chemical compound C1[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]2[C@H](O)C[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C PRAUVHZJPXOEIF-AOLYGAPISA-N 0.000 claims abstract description 8
- 229940011656 madecassic acid Drugs 0.000 claims abstract description 8
- BUWCHLVSSFQLPN-UHFFFAOYSA-N madecassic acid Natural products CC1CCC2(CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C5CCC34C)C(=O)O)C2C1C)C(=O)OC6OC(COC7OC(CO)C(OC8OC(C)C(O)C(O)C8O)C(O)C7O)C(O)C(O)C6O BUWCHLVSSFQLPN-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229940067082 pentetate Drugs 0.000 claims abstract description 8
- 229940068041 phytic acid Drugs 0.000 claims abstract description 8
- 235000002949 phytic acid Nutrition 0.000 claims abstract description 8
- 239000000467 phytic acid Substances 0.000 claims abstract description 8
- 229910001923 silver oxide Inorganic materials 0.000 claims abstract description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 90
- 238000001816 cooling Methods 0.000 claims description 75
- 230000001804 emulsifying effect Effects 0.000 claims description 50
- 239000000463 material Substances 0.000 claims description 41
- 238000002156 mixing Methods 0.000 claims description 30
- 238000010438 heat treatment Methods 0.000 claims description 10
- 239000002245 particle Substances 0.000 claims description 6
- 239000000498 cooling water Substances 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 238000007599 discharging Methods 0.000 claims description 5
- 238000000265 homogenisation Methods 0.000 claims description 5
- 238000007689 inspection Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 238000005070 sampling Methods 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims 5
- 239000003973 paint Substances 0.000 claims 2
- 230000008439 repair process Effects 0.000 abstract description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 210000002950 fibroblast Anatomy 0.000 description 4
- 229920002683 Glycosaminoglycan Polymers 0.000 description 3
- 206010040925 Skin striae Diseases 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 102000012422 Collagen Type I Human genes 0.000 description 1
- 108010022452 Collagen Type I Proteins 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000651 myofibroblast Anatomy 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to a damaged skin repairing gel which comprises the following components in percentage by weight: adding water to 100%; 0.3-1.5% of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer; 5-10% of water; 0.3-1.5% of p-hydroxyacetophenone, 0.1-0.3% of allantoin and 2-5% of glycerol; 2-5% of propylene glycol and 0.05-0.3% of sodium hyaluronate; 0.3-1.5% of triethanolamine and 0.3-1.5% of water; 0.05-0.3% of dipotassium glycyrrhizinate and 1-3% of propylene glycol; 0.2-1% of 1, 2-hexanediol; 5-20% of calcium sodium phosphosilicate; 0.05-0.3% of asiaticoside, 0.05-0.3% of asiatic acid, 0.05-0.3% of madecassic acid and 2-5% of water; 0.1-0.5% of silver oxide, 0.05-0.3% of phytic acid, 0.05-0.3% of pentetate and 1-5% of ethanol; 0.3-1.5% of glycerol glucoside; its preparing process is also disclosed. The invention has the advantages that: can repair damaged skin and improve problem skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a damaged skin repairing gel and a preparation process thereof.
Background
Due to the rapid development of Chinese economy in recent years, the living standard of people is improved rapidly, the material culture demand is also greatly improved, and the cosmetic market is explosively increased.
The world health organization (WTO) has reported that: "in modern people, skin is less than 20% healthy, more than 20% sick, and in between 70% of sub-healthy skin population".
The huge demand of consumers on whitening products and the excessive pursuit of the consumers on products with quick effect lead to the overproof of heavy metals and the remarkable abuse phenomenon of hormones in the products, thus causing huge harm to the consumers who love beauty and love whitening.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a damaged skin repairing gel and a preparation process thereof.
The purpose of the invention is realized by the following technical scheme:
a damaged skin repairing gel comprises the following components in percentage by weight:
phase A component: adding water to 100%;
phase B component: 0.3-1.5% of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer;
phase C component: 5-10% of water;
phase D component: 0.3-1.5% of p-hydroxyacetophenone, 0.1-0.3% of allantoin and 2-5% of glycerol;
phase E component: 2-5% of propylene glycol and 0.05-0.3% of sodium hyaluronate;
phase F component: 0.3-1.5% of triethanolamine and 0.3-1.5% of water;
phase G component: 0.05-0.3% of dipotassium glycyrrhizinate and 1-3% of propylene glycol;
phase H component: 0.2-1% of 1, 2-hexanediol;
phase I component: 5-20% of calcium sodium phosphosilicate;
phase J component: 0.05-0.3% of asiaticoside, 0.05-0.3% of asiatic acid, 0.05-0.3% of madecassic acid and 2-5% of water;
phase K component: 0.1-0.5% of silver oxide, 0.05-0.3% of phytic acid, 0.05-0.3% of pentetate and 1-5% of ethanol;
l-phase component: 0.3-1.5% of glycerol glucoside.
The damaged skin repairing gel comprises the following components in percentage by weight:
phase A component: adding water to 100%;
phase B component: acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.9%;
phase C component: 7.5 percent of water;
phase D component: 0.9% of p-hydroxyacetophenone, 0.2% of allantoin and 3.5% of glycerol;
phase E component: 3.5 percent of propylene glycol and 0.15 percent of sodium hyaluronate;
phase F component: triethanolamine 0.9% and water 0.9%;
phase G component: 0.16% of dipotassium glycyrrhizinate and 2% of propylene glycol;
phase H component: 0.6 percent of 1, 2-hexanediol;
phase I component: 12.5 percent of calcium sodium phosphosilicate;
phase J component: asiaticoside 0.15%, asiatic acid 0.15%, madecassic acid 0.15%, water 3.5%;
phase K component: 0.3% of silver oxide, 0.15% of phytic acid, 0.15% of pentetate and 3% of ethanol;
l-phase component: glycerol glucoside 0.9%.
Further, the water is deionized water.
The preparation process of the damaged skin repairing gel comprises the following steps:
s1, mixing and stirring the materials of the phase E component uniformly for later use;
s2, mixing and stirring the materials of the phase F component until the materials are completely transparent for later use;
s3, mixing and stirring the materials of the G phase component until no cluster or particle exists for later use;
s4, mixing, stirring and dissolving the materials of the J-phase component until the materials are completely transparent for later use;
s5, mixing, stirring and dissolving all the materials of the K phase component to be transparent for later use;
s6, heating the C-phase component to 95-100 ℃, preserving heat for 8-12 min, and cooling to 40 ℃ for later use;
s7, adding the phase B component into the phase C component, and stirring and dispersing for later use;
s8, adding the phase A component into an emulsifying pot, stirring and heating to 85-88 ℃, and keeping the temperature for 10-20 min;
s9, adding the mixture obtained in the step S7 into an emulsifying pot, starting homogenizing at the speed of 8-12 rpm for 0.5-1.5 min;
s10, adding the D-phase components into an emulsifying pot, starting homogenization at the speed of 15-18 rpm for 1-3 min, and starting cooling water to cool;
s11, cooling to 60-63 ℃, adding the phase E component into an emulsifying pot, homogenizing at the speed of 10-13 rpm for 0.5-1.5 min, stirring uniformly, and then continuing cooling;
s12, cooling to 58-60 ℃, adding the F phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s13, cooling to 53-55 ℃, adding the G phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s14, cooling to 48-50 ℃, adding the J-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s15, cooling to 40-42 ℃, sequentially adding the H-phase component and the I-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s16, cooling to 38-40 ℃, adding the K phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s17, cooling to below 38 ℃, adding the L-phase component into an emulsifying pot, and stirring for 12-18 min to ensure that all materials are uniformly stirred;
and S18, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
Further, in the steps S1 to S5, the stirring speed is 20 to 30rpm during the mixing and stirring.
Further, during stirring, a forward and reverse rotation alternative stirring method is adopted, and the forward and reverse rotation switching time is 1-2 min.
Further, in steps S11-S17, the cooling rate is 1-3 ℃/min.
Further, in step S10, after homogenizing, heat preservation is carried out, wherein the heat preservation temperature is 85-88 ℃, and the heat preservation time is 18-22 min.
The invention has the following advantages:
1. the damaged skin repairing gel contains calcium sodium phosphosilicate, has a microporous structure and a large surface area, and can adsorb active factors, asiaticoside, glycerol glucoside and the like, so that the damaged skin repairing gel is helpful for skin repair.
2. Compared with common products containing silver ions in the market, the damaged skin repairing gel has a larger and more uniform surface area, can effectively exert an antibacterial effect, has broad-spectrum antibacterial effect, and can inhibit the growth of acne bacteria. Reduce the formation of 'smallpox muscle' and is beneficial to the repair of skin.
3. The damaged skin repairing gel does not contain a traditional preservative, has good biocompatibility and skin-friendly property, has no cytotoxicity and no skin irritation, and can be used for a long time.
4. The calcium sodium phosphosilicate retains the activity of highly coordinated silicon atoms, can be instantly activated when contacting body fluid, continuously forms soluble silicon, continuously releases a large amount of calcium ions and phosphate radical particles, and forms a silicon gel layer with negative electricity on the surface. Silicon element is one of indispensable trace elements of human body, is an important component of extracellular matrix (ECM) in connective tissue, and can form a skeleton structure for maintaining normal state of skin with glycosaminoglycan and related protein complex to promote rapid repair of damaged tissue.
5. Asiaticoside and asiatic acid activate fibroblast structure, promote synthesis of collagen I & III, increase secretion of cell mucopolysaccharide (GAGS), and promote synthesis of fibroblast. And the calcium sodium phosphosilicate can promote the fibroblast to rapidly migrate to the wound surface, inhibit the fibroblast from differentiating to the myofibroblast and effectively inhibit the generation of pathological scars.
Detailed Description
The invention is further described below with reference to examples, but the scope of the invention is not limited to the following.
[ example 1 ]:
a damaged skin repairing gel comprises the following components in percentage by weight:
phase A component: adding water to 100%;
phase B component: acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 1.5%;
phase C component: 5% of water;
phase D component: 1.5% of p-hydroxyacetophenone, 0.1% of allantoin and 5% of glycerol;
phase E component: 2% of propylene glycol and 0.3% of sodium hyaluronate;
phase F component: 0.3 percent of triethanolamine and 1.5 percent of water;
phase G component: 0.05% of dipotassium glycyrrhizinate and 3% of propylene glycol;
phase H component: 0.2% of 1, 2-hexanediol;
phase I component: 20% of sodium calcium phosphosilicate;
phase J component: asiaticoside 0.05%, asiatic acid 0.3%, madecassic acid 0.05%, water 5%;
phase K component: 0.1% of silver oxide, 0.3% of phytic acid, 0.05% of pentetate and 5% of ethanol;
l-phase component: glycerol glucoside 0.3%.
Further, the water is deionized water.
The preparation process of the damaged skin repairing gel comprises the following steps:
s1, mixing and stirring the materials of the phase E component uniformly for later use;
s2, mixing and stirring the materials of the phase F component until the materials are completely transparent for later use;
s3, mixing and stirring the materials of the G phase component until no cluster or particle exists for later use;
s4, mixing, stirring and dissolving the materials of the J-phase component until the materials are completely transparent for later use;
s5, mixing, stirring and dissolving all the materials of the K phase component to be transparent for later use;
s6, heating the C phase component to 100 ℃, preserving heat for 8min, and then cooling to 40 ℃ for later use;
s7, adding the phase B component into the phase C component, and stirring and dispersing for later use;
s8, adding the phase A component into an emulsifying pot, stirring and heating to 88 ℃, and preserving heat for 10 min;
s9, adding the mixture obtained in the step S7 into an emulsifying pot, starting homogenizing at the speed of 12rpm for 0.5 min;
s10, adding the D-phase components into an emulsifying pot, starting homogenization at the speed of 18rpm for 1min, preserving heat at 88 ℃ for 18min, and starting cooling water to reduce the temperature;
s11, cooling to 63 ℃, adding the phase E component into an emulsifying pot, homogenizing at the speed of 10rpm for 1.5min, stirring uniformly, and then continuing cooling;
s12, cooling to 58 ℃, adding the F phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s13, cooling to 55 ℃, adding the G-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s14, cooling to 48 ℃, adding the J-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s15, cooling to 42 ℃, sequentially adding the H-phase component and the I-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s16, cooling to 38 ℃, adding the K-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s17, cooling to below 38 ℃, adding the L-phase component into an emulsifying pot, and stirring for 18min to ensure that all materials are uniformly stirred;
and S18, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
In this embodiment, in steps S1 to S5, the stirring speed is 20rpm during the mixing and stirring, and more preferably, the stirring is performed by a forward/reverse alternate stirring method, and the forward/reverse switching time is 2 min.
In the present embodiment, in steps S11 to S17, the cooling rate is 3 ℃/min.
[ example 2 ]:
a damaged skin repairing gel comprises the following components in percentage by weight:
phase A component: adding water to 100%;
phase B component: acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.9%;
phase C component: 7.5 percent of water;
phase D component: 0.9% of p-hydroxyacetophenone, 0.2% of allantoin and 3.5% of glycerol;
phase E component: 3.5 percent of propylene glycol and 0.15 percent of sodium hyaluronate;
phase F component: triethanolamine 0.9% and water 0.9%;
phase G component: 0.16% of dipotassium glycyrrhizinate and 2% of propylene glycol;
phase H component: 0.6 percent of 1, 2-hexanediol;
phase I component: 12.5 percent of calcium sodium phosphosilicate;
phase J component: asiaticoside 0.15%, asiatic acid 0.15%, madecassic acid 0.15%, water 3.5%;
phase K component: 0.3% of silver oxide, 0.15% of phytic acid, 0.15% of pentetate and 3% of ethanol;
l-phase component: glycerol glucoside 0.9%.
Further, the water is deionized water.
The preparation process of the damaged skin repairing gel comprises the following steps:
s1, mixing and stirring the materials of the phase E component uniformly for later use;
s2, mixing and stirring the materials of the phase F component until the materials are completely transparent for later use;
s3, mixing and stirring the materials of the G phase component until no cluster or particle exists for later use;
s4, mixing, stirring and dissolving the materials of the J-phase component until the materials are completely transparent for later use;
s5, mixing, stirring and dissolving all the materials of the K phase component to be transparent for later use;
s6, heating the C-phase component to 95-100 ℃, preserving heat for 8-12 min, and cooling to 40 ℃ for later use;
s7, adding the phase B component into the phase C component, and stirring and dispersing for later use;
s8, adding the phase A component into an emulsifying pot, stirring and heating to 85-88 ℃, and keeping the temperature for 10-20 min;
s9, adding the mixture obtained in the step S7 into an emulsifying pot, starting homogenizing at the speed of 8-12 rpm for 0.5-1.5 min;
s10, adding the D-phase components into an emulsifying pot, starting homogenization at the speed of 15-18 rpm for 1-3 min, preserving heat at 85-88 ℃ for 18-22 min, and starting cooling water to cool;
s11, cooling to 60-63 ℃, adding the phase E component into an emulsifying pot, homogenizing at the speed of 10-13 rpm for 0.5-1.5 min, stirring uniformly, and then continuing cooling;
s12, cooling to 58-60 ℃, adding the F phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s13, cooling to 53-55 ℃, adding the G phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s14, cooling to 48-50 ℃, adding the J-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s15, cooling to 40-42 ℃, sequentially adding the H-phase component and the I-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s16, cooling to 38-40 ℃, adding the K phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s17, cooling to below 38 ℃, adding the L-phase component into an emulsifying pot, and stirring for 12-18 min to ensure that all materials are uniformly stirred;
and S18, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
In this example, in steps S1 to S5, the stirring speed is 25rpm during the mixing and stirring, and more preferably, the stirring is performed by a forward/reverse alternate stirring method, and the forward/reverse switching time is 1.5 min.
In the present embodiment, in steps S11 to S17, the cooling rate is 2 ℃/min.
[ example 3 ]:
a damaged skin repairing gel comprises the following components in percentage by weight:
phase A component: adding water to 100%;
phase B component: acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.3%;
phase C component: 10% of water;
phase D component: 0.3% of p-hydroxyacetophenone, 0.3% of allantoin and 2% of glycerol;
phase E component: 5% of propylene glycol and 0.05% of sodium hyaluronate;
phase F component: 1.5 percent of triethanolamine and 0.3 percent of water;
phase G component: 0.3% of dipotassium glycyrrhizinate and 1% of propylene glycol;
phase H component: 1% of 1, 2-hexanediol;
phase I component: 5% of sodium calcium phosphosilicate;
phase J component: asiaticoside 0.3%, asiatic acid 0.05%, madecassic acid 0.3%, water 2%;
phase K component: 0.5% of silver oxide, 0.05% of phytic acid, 0.3% of pentetate and 1% of ethanol;
l-phase component: glycerol glucoside 1.5%.
Further, the water is deionized water.
The preparation process of the damaged skin repairing gel comprises the following steps:
s1, mixing and stirring the materials of the phase E component uniformly for later use;
s2, mixing and stirring the materials of the phase F component until the materials are completely transparent for later use;
s3, mixing and stirring the materials of the G phase component until no cluster or particle exists for later use;
s4, mixing, stirring and dissolving the materials of the J-phase component until the materials are completely transparent for later use;
s5, mixing, stirring and dissolving all the materials of the K phase component to be transparent for later use;
s6, heating the C phase component to 95 ℃, preserving heat for 12min, and then cooling to 40 ℃ for later use;
s7, adding the phase B component into the phase C component, and stirring and dispersing for later use;
s8, adding the phase A component into an emulsifying pot, stirring and heating to 85 ℃, and keeping the temperature for 20 min;
s9, adding the mixture obtained in the step S7 into an emulsifying pot, starting homogenizing at the speed of 8rpm for 1.5 min;
s10, adding the D-phase components into an emulsifying pot, starting homogenization at the speed of 15rpm for 3min, preserving heat at 85 ℃ for 22min, and starting cooling water to cool;
s11, cooling to 60 ℃, adding the phase E component into an emulsifying pot, homogenizing at the speed of 13rpm for 0.5min, stirring uniformly, and then continuing cooling;
s12, cooling to 60 ℃, adding the F phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s13, cooling to 53 ℃, adding the G-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s14, cooling to 50 ℃, adding the J-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s15, cooling to 40 ℃, sequentially adding the H-phase component and the I-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s16, cooling to 40 ℃, adding the K-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s17, cooling to below 38 ℃, adding the L-phase component into an emulsifying pot, and stirring for 12-18 min to ensure that all materials are uniformly stirred;
and S18, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
In this embodiment, in steps S1 to S5, the stirring speed is 30rpm during the mixing and stirring, and more preferably, the stirring is performed by a forward/reverse alternate stirring method, and the forward/reverse switching time is 1 min.
In the present embodiment, in steps S11 to S17, the cooling rate is 1 ℃/min.
Comparative experiment:
40 volunteers with striae gravidarum aged 25-35 years are randomly divided into 4 groups, the first group is a blank control group without adding sodium calcium phosphosilicate and asiaticoside in example 1, the products obtained in examples 1, 2 and 3 are respectively used in the second group, the third group and the fourth group to carry out double-blind experiments, the damaged skin repairing gel is used 2 times every day for three months, and meanwhile, the reduction ratio of the width, the length and the color of the striae gravidarum to the products before the test is recorded.
According to the table, the addition of calcium sodium phosphosilicate and asiaticoside to the blank control sample can effectively and quickly reduce the width, length and color depth of striae gravidarum, and has obvious test effects on repairing damaged skin and improving problem skin.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A damaged skin repairing gel, which is characterized in that: the paint consists of the following components in percentage by weight:
phase A component: adding water to 100%;
phase B component: 0.3-1.5% of acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer;
phase C component: 5-10% of water;
phase D component: 0.3-1.5% of p-hydroxyacetophenone, 0.1-0.3% of allantoin and 2-5% of glycerol;
phase E component: 2-5% of propylene glycol and 0.05-0.3% of sodium hyaluronate;
phase F component: 0.3-1.5% of triethanolamine and 0.3-1.5% of water;
phase G component: 0.05-0.3% of dipotassium glycyrrhizinate and 1-3% of propylene glycol;
phase H component: 0.2-1% of 1, 2-hexanediol;
phase I component: 5-20% of calcium sodium phosphosilicate;
phase J component: 0.05-0.3% of asiaticoside, 0.05-0.3% of asiatic acid, 0.05-0.3% of madecassic acid and 2-5% of water;
phase K component: 0.1-0.5% of silver oxide, 0.05-0.3% of phytic acid, 0.05-0.3% of pentetate and 1-5% of ethanol;
l-phase component: 0.3-1.5% of glycerol glucoside.
2. The damaged skin repairing gel according to claim 1, wherein: the paint consists of the following components in percentage by weight:
phase A component: adding water to 100%;
phase B component: acrylic acid (ester)/C10-30 alkanol acrylate crosspolymer 0.9%;
phase C component: 7.5 percent of water;
phase D component: 0.9% of p-hydroxyacetophenone, 0.2% of allantoin and 3.5% of glycerol;
phase E component: 3.5 percent of propylene glycol and 0.15 percent of sodium hyaluronate;
phase F component: triethanolamine 0.9% and water 0.9%;
phase G component: 0.16% of dipotassium glycyrrhizinate and 2% of propylene glycol;
phase H component: 0.6 percent of 1, 2-hexanediol;
phase I component: 12.5 percent of calcium sodium phosphosilicate;
phase J component: asiaticoside 0.15%, asiatic acid 0.15%, madecassic acid 0.15%, water 3.5%;
phase K component: 0.3% of silver oxide, 0.15% of phytic acid, 0.15% of pentetate and 3% of ethanol;
l-phase component: glycerol glucoside 0.9%.
3. The damaged skin repairing gel according to claim 1 or 2, wherein: the water is deionized water.
4. A process for preparing a damaged skin repairing gel according to any one of claims 1 to 3, wherein: the method comprises the following steps:
s1, mixing and stirring the materials of the phase E component uniformly for later use;
s2, mixing and stirring the materials of the phase F component until the materials are completely transparent for later use;
s3, mixing and stirring the materials of the G phase component until no cluster or particle exists for later use;
s4, mixing, stirring and dissolving the materials of the J-phase component until the materials are completely transparent for later use;
s5, mixing, stirring and dissolving all the materials of the K phase component to be transparent for later use;
s6, heating the C-phase component to 95-100 ℃, preserving heat for 8-12 min, and cooling to 40 ℃ for later use;
s7, adding the phase B component into the phase C component, and stirring and dispersing for later use;
s8, adding the phase A component into an emulsifying pot, stirring and heating to 85-88 ℃, and keeping the temperature for 10-20 min;
s9, adding the mixture obtained in the step S7 into an emulsifying pot, starting homogenizing at the speed of 8-12 rpm for 0.5-1.5 min;
s10, adding the D-phase components into an emulsifying pot, starting homogenization at the speed of 15-18 rpm for 1-3 min, and starting cooling water to cool;
s11, cooling to 60-63 ℃, adding the phase E component into an emulsifying pot, homogenizing at the speed of 10-13 rpm for 0.5-1.5 min, stirring uniformly, and then continuing cooling;
s12, cooling to 58-60 ℃, adding the F phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s13, cooling to 53-55 ℃, adding the G phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s14, cooling to 48-50 ℃, adding the J-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s15, cooling to 40-42 ℃, sequentially adding the H-phase component and the I-phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s16, cooling to 38-40 ℃, adding the K phase component into an emulsifying pot, uniformly stirring, and continuously cooling;
s17, cooling to below 38 ℃, adding the L-phase component into an emulsifying pot, and stirring for 12-18 min to ensure that all materials are uniformly stirred;
and S18, sampling, inspecting, and discharging after inspection is qualified to obtain the product.
5. The process for preparing a damaged skin repairing gel according to claim 4, wherein: in steps S1 to S5, the stirring speed is 20 to 30rpm during the mixing and stirring.
6. The process for preparing a damaged skin repairing gel according to claim 5, wherein: and during stirring, a forward and reverse rotation alternative stirring method is adopted, and the forward and reverse rotation switching time is 1-2 min.
7. The process for preparing a damaged skin repairing gel according to claim 4, wherein: in steps S11-S17, the cooling rate is 1-3 ℃/min.
8. The process for preparing a damaged skin repairing gel according to claim 4, wherein: in step S10, after homogenizing, carrying out heat preservation at the temperature of 85-88 ℃ for 18-22 min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010923922.5A CN112006938A (en) | 2020-09-04 | 2020-09-04 | Damaged skin repairing gel and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010923922.5A CN112006938A (en) | 2020-09-04 | 2020-09-04 | Damaged skin repairing gel and preparation process thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112006938A true CN112006938A (en) | 2020-12-01 |
Family
ID=73516913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010923922.5A Pending CN112006938A (en) | 2020-09-04 | 2020-09-04 | Damaged skin repairing gel and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112006938A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451460A (en) * | 2020-12-31 | 2021-03-09 | 广州市医康生物科技有限公司 | Extraction method of crocus sativus extract and stretch mark removing cream containing extract |
| CN113018218A (en) * | 2021-03-09 | 2021-06-25 | 仲媄生物科技(山东)有限公司 | Abdominal skin repair essence and preparation method thereof |
| CN114605932A (en) * | 2022-05-10 | 2022-06-10 | 北京国械堂科技发展有限责任公司 | Medical gel for treating brain glioma by electric field and preparation method thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104414914A (en) * | 2013-08-28 | 2015-03-18 | 青岛医防消毒专业技术中心 | Striae gravidarum recovery essence |
| CN104814901A (en) * | 2015-05-18 | 2015-08-05 | 南阳市汇博生物技术有限公司 | Striae gravidarum preventing gel and preparation method thereof |
| CN108420786A (en) * | 2018-05-15 | 2018-08-21 | 李亮 | A kind of skin maintenance gel formula |
| CN108785664A (en) * | 2018-06-11 | 2018-11-13 | 成都新柯力化工科技有限公司 | A kind of control release type repairs scar beauty-care gel material and preparation method |
| CN109568152A (en) * | 2018-12-30 | 2019-04-05 | 艾因特丽（苏州）生物科技有限公司 | A kind of compound gel preparation and preparation method thereof for repairing striae of pregnancy |
| CN109674686A (en) * | 2019-01-22 | 2019-04-26 | 华熙福瑞达生物医药有限公司 | A kind of composition and preparation method thereof of maintenance damaged skin |
| CN109771308A (en) * | 2018-05-29 | 2019-05-21 | 北京幸福益生高新技术有限公司 | A kind of formula and preparation method of striae of pregnancy reparation |
| CN110151624A (en) * | 2019-06-13 | 2019-08-23 | 广州方媚化妆品有限公司 | Striae of pregnancy, which is smeared, repairs essence cream |
| CN110917060A (en) * | 2019-12-26 | 2020-03-27 | 厦门泽本健康管理有限公司 | Whitening and repairing acne removing lotion containing flavone compound and organic mixed acid |
-
2020
- 2020-09-04 CN CN202010923922.5A patent/CN112006938A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104414914A (en) * | 2013-08-28 | 2015-03-18 | 青岛医防消毒专业技术中心 | Striae gravidarum recovery essence |
| CN104814901A (en) * | 2015-05-18 | 2015-08-05 | 南阳市汇博生物技术有限公司 | Striae gravidarum preventing gel and preparation method thereof |
| CN108420786A (en) * | 2018-05-15 | 2018-08-21 | 李亮 | A kind of skin maintenance gel formula |
| CN109771308A (en) * | 2018-05-29 | 2019-05-21 | 北京幸福益生高新技术有限公司 | A kind of formula and preparation method of striae of pregnancy reparation |
| CN108785664A (en) * | 2018-06-11 | 2018-11-13 | 成都新柯力化工科技有限公司 | A kind of control release type repairs scar beauty-care gel material and preparation method |
| CN109568152A (en) * | 2018-12-30 | 2019-04-05 | 艾因特丽（苏州）生物科技有限公司 | A kind of compound gel preparation and preparation method thereof for repairing striae of pregnancy |
| CN109674686A (en) * | 2019-01-22 | 2019-04-26 | 华熙福瑞达生物医药有限公司 | A kind of composition and preparation method thereof of maintenance damaged skin |
| CN110151624A (en) * | 2019-06-13 | 2019-08-23 | 广州方媚化妆品有限公司 | Striae of pregnancy, which is smeared, repairs essence cream |
| CN110917060A (en) * | 2019-12-26 | 2020-03-27 | 厦门泽本健康管理有限公司 | Whitening and repairing acne removing lotion containing flavone compound and organic mixed acid |
Non-Patent Citations (1)
| Title |
|---|
| 西安绿天生物技术有限公司: ""积雪草提取物在化妆品中的修复作用"", 《百度》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112451460A (en) * | 2020-12-31 | 2021-03-09 | 广州市医康生物科技有限公司 | Extraction method of crocus sativus extract and stretch mark removing cream containing extract |
| CN113018218A (en) * | 2021-03-09 | 2021-06-25 | 仲媄生物科技(山东)有限公司 | Abdominal skin repair essence and preparation method thereof |
| CN114605932A (en) * | 2022-05-10 | 2022-06-10 | 北京国械堂科技发展有限责任公司 | Medical gel for treating brain glioma by electric field and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112006938A (en) | Damaged skin repairing gel and preparation process thereof | |
| CN108969429B (en) | Acne removing essence | |
| CN109528564B (en) | Skin care composition and cosmetic preparation | |
| CN107898660A (en) | A kind of tender skin water light stoste and its preparation method and application | |
| CN109568151A (en) | A kind of Essence skin care moisture saver mask and preparation method thereof containing small-molecular peptides | |
| CN113230196B (en) | Anti-aging repairing essence and preparation method thereof | |
| CN113616566A (en) | Skin care essence for tightening skin and preparation method thereof | |
| CN111939116A (en) | Anti-aging composition and preparation method thereof | |
| CN110917055A (en) | Oligopeptide repair essence and preparation process thereof | |
| CN109260075B (en) | Acne-removing conditioning water | |
| CN107595677A (en) | A kind of lustrous and transparent lip gloss and preparation method thereof | |
| CN112043619A (en) | Peptide composition with repairing effect and preparation method and application thereof | |
| CN113018228B (en) | Anti-aging composition, cream and preparation method thereof | |
| CN113648274A (en) | Anti-aging composition and preparation method and application thereof | |
| CN117357447A (en) | Paeonia lactiflora whitening and freckle removing extracting solution | |
| CN108210442A (en) | Skin care compositions of mild high nutrition and its preparation method and application | |
| CN111904915A (en) | Whitening and freckle removing composition and preparation method and application thereof | |
| CN109260086B (en) | Anti-wrinkle essence, preparation method and application thereof | |
| CN103599054B (en) | Containing the facial film and preparation method thereof of peanut protein polypeptide | |
| CN108451852A (en) | A kind of exfoliating composition | |
| CN110025515B (en) | Anti-allergy polysaccharide compound composition and application thereof in cosmetics | |
| CN111053721B (en) | Silky glowing eye cream and preparation method thereof | |
| CN112089677A (en) | Moisturizing and whitening skin-care pearl lotion and preparation method thereof | |
| CN112245381A (en) | Skin care product capable of resisting oxidation and improving skin defense capacity | |
| CN113750027A (en) | Formula and preparation process of collagen energized emulsion |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201201 |