CN105873567A - Process for forming an integral film product - Google Patents
Process for forming an integral film product Download PDFInfo
- Publication number
- CN105873567A CN105873567A CN201480071882.9A CN201480071882A CN105873567A CN 105873567 A CN105873567 A CN 105873567A CN 201480071882 A CN201480071882 A CN 201480071882A CN 105873567 A CN105873567 A CN 105873567A
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- CN
- China
- Prior art keywords
- mask
- substrate
- acid
- film
- body membrane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/28—Processes for applying liquids or other fluent materials performed by transfer from the surfaces of elements carrying the liquid or other fluent material, e.g. brushes, pads, rollers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05D1/00—Processes for applying liquids or other fluent materials
- B05D1/32—Processes for applying liquids or other fluent materials using means for protecting parts of a surface not to be coated, e.g. using stencils, resists
- B05D1/322—Removable films used as masks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41F—PRINTING MACHINES OR PRESSES
- B41F15/00—Screen printers
- B41F15/08—Machines
- B41F15/0831—Machines for printing webs
- B41F15/0836—Machines for printing webs by means of cylindrical screens or screens in the form of endless belts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41F—PRINTING MACHINES OR PRESSES
- B41F15/00—Screen printers
- B41F15/08—Machines
- B41F15/0831—Machines for printing webs
- B41F15/0845—Machines for printing webs with flat screens
- B41F15/085—Machines for printing webs with flat screens with a stationary screen and a moving squeegee
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41F—PRINTING MACHINES OR PRESSES
- B41F15/00—Screen printers
- B41F15/08—Machines
- B41F15/12—Machines with auxiliary equipment, e.g. for drying printed articles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41F—PRINTING MACHINES OR PRESSES
- B41F15/00—Screen printers
- B41F15/14—Details
- B41F15/40—Inking units
- B41F15/42—Inking units comprising squeegees or doctors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41L—APPARATUS OR DEVICES FOR MANIFOLDING, DUPLICATING OR PRINTING FOR OFFICE OR OTHER COMMERCIAL PURPOSES; ADDRESSING MACHINES OR LIKE SERIES-PRINTING MACHINES
- B41L13/00—Stencilling apparatus for office or other commercial use
- B41L13/02—Stencilling apparatus for office or other commercial use with flat stencil carriers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41L—APPARATUS OR DEVICES FOR MANIFOLDING, DUPLICATING OR PRINTING FOR OFFICE OR OTHER COMMERCIAL PURPOSES; ADDRESSING MACHINES OR LIKE SERIES-PRINTING MACHINES
- B41L13/00—Stencilling apparatus for office or other commercial use
- B41L13/04—Stencilling apparatus for office or other commercial use with curved or rotary stencil carriers
- B41L13/06—Stencilling apparatus for office or other commercial use with curved or rotary stencil carriers with a single cylinder carrying the stencil
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
- B41M1/00—Inking and printing with a printer's forme
- B41M1/12—Stencil printing; Silk-screen printing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
- Y10T428/24752—Laterally noncoextensive components
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cosmetics (AREA)
- Moulding By Coating Moulds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Confectionery (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Abstract
A process, capable of commercial scale manufacturing of inexpensive, integral film product without the waste of die-cutting and which products are capable of use independent of a supporting structure on which they are formed, includes placing a mask over a substrate having a releasable surface, delivering a film-forming composition through the mask to form a raw shape on the substrate; removing the mask, and solidifying the raw shape into the integral film product disposed on the substrate. The mask has at least one aperture having a shape corresponding to the desired integral film product. The integral film product is arranged and configured to be removable from the releasable surface of the substrate for use independent of the substrate.
Description
Background technology
One body membrane product tool has been widely used, including decoration window decal paper, plaster, adhesive bandage
With oral tablet (including medicinal and other purposes).
The conventional production process of a this body membrane product is usually directed to the product from raw stock cross cutting required form
Product.Although this production method has produced cheap raw stock, but cross cutting limits final products and shapes
Efficiency and/or variability.If shape of product is not rectangle or inlay the most completely completely
Embedding, then trapezoidal waste material around can cause significantly waste.Therefore, there is the product of expensive raw materials
It is conventionally limited to square or other shape inlayed completely, to substantially eliminate this bigger wave
Take.Unfortunately, which hinders the formation of the optimum shape for some purposes.Cross cutting medical films
Example includes the production technology described in following patent: Pharmedica Ltd., WO 2012104834
A1, Pinna et al., United States Patent (USP) 7612048B2 and Smithkline Beecham Corp., WO
2005/009386A2。
On the other hand, printing (including stencilization and silk screen printing) is to be known to carry in substrate
For erose method.Typically, printing material keeps the shape of permanent combination in substrate
State, such as the word of printing and figure on the printed circuit on paper, in electronics industry, and at clothes
With the pattern of printing on label.But, bearing basement is integrated on printed element and prevents printing
Product is independent of the usage of substrate.
This is accomplished by a kind of method, it is possible to the business realizing the cheap body membrane product without cross cutting waste is advised
Mould produces, and this product can use independent of the supporting construction being formed on.
Summary of the invention
Surprisingly, we have discovered a kind of method, the method is capable of without cross cutting wave
The commercial mass production of the cheap body membrane product taken, and this product can be independent of being formed on
Supporting construction use.The method includes: be placed on by mask in the substrate with peelable surface,
By mask delivery film-forming composition, to form original-shape in substrate；Remove mask, and make
Original-shape is converted into and is arranged on a suprabasil body membrane product.Mask has at least one hole, its tool
There is the shape corresponding to a required body membrane product.One body membrane product is arranged and be configured to can be from substrate
Peelable surface removes, in order to use independent of substrate.
In an alternative embodiment, the method for formation one body membrane product includes: put by mask
Put in the substrate with peelable surface, by mask delivery film-forming composition to be formed in substrate
Original-shape；Remove mask, and original-shape is solidified into is arranged on a suprabasil body membrane product.
Film-forming composition and therefore a body membrane product include beneficial agent, and a body membrane product has the first table
Face, it is arranged and is configured to remove from the peelable surface of substrate, in order to make independent of substrate
With.Beneficial agent can deliver the first surface by a body membrane product.
Accompanying drawing explanation
Fig. 1 is the block diagram of the method according to one embodiment of the invention.
Fig. 2 is the perspective of the most useful flat board stencilization system
Figure.
Fig. 3 is the most useful perspective rotating masterplate print system
Figure.
Fig. 4 be the side of the most useful flat bed screen print system just
View.
Fig. 5 be the side of the most useful rotary screen print system just
View.
Fig. 6 A-6D is the profile of a body membrane product of the present invention.
Fig. 7 A-7E is a series of schematic side elevation view of method step, it is shown that the one of the present invention
The formation of film product.
Fig. 8 is the chart of die board mask and finished product thickness.
Fig. 9 is the chart of screen mask and finished product thickness.
Detailed description of the invention
The present invention relates to a kind of method and apparatus for forming a body membrane product.Be given and be described below
So that those of ordinary skill in the art can make and use the present invention.To embodiment party described herein
The various amendments of case and General Principle and feature will be apparent for a person skilled in the art
's.Therefore, the present invention is not intended to be limited to the embodiment illustrated, and is to fit to and institute herein
The widest scope that the principle stated is consistent with feature.One body membrane product can have and has been widely used.Including family
Front yard and recreational use, such as the decorative paste marble paper of window and wall, temporary tatt is (such as health applique
Paper), armarium, such as medicinal and/or the wound covering thing such as absorbent plaster, binding agent binder, mouth
Take sheet, also referred to as " consumable films " (medicinal, therapeutic agent and cosmetics), the film of other health
Sheet, as moisturizing treatment acne, crease-resistant, black eye, grace, liparitosis, vitamin be administered, wet
Rash, psoriasis etc..
As used in this paper description and claims, the variant of term " body membrane product " relates to
And to a kind of film product, it is sufficiently solid, it is allowed to it separated with any support substrate for required purpose
Process.This product can remove from substrate, in order to uses independent of substrate.
As used in this paper description and claims, the variant of term " film-forming composition " relates to
And a kind of compositions, its can on a substrate by itself or in the presence of other activating agent,
Form continuous print film.
As used in this paper description and claims, the variant of term " original-shape " relates to
By there being aperture mask to be arranged on the shaping volume of suprabasil film-forming composition.Original-shape typically requires
Further process, as integrated to be converted into a body membrane product.
As used in this paper specification and claims, the variant that term " solidifies " relate to from
Liquid, to the phase transformation of solid, can be evaporated by solvent, temperature reduce, is polymerized, crosslinking etc..
As used in this paper specification and claims, term " is inlayed " and variant relates to
There is the pattern of flat shape but not there is the flat surfaces in overlap or gap.Therefore, there is not shape
Between " scalariform waste ".
Seeing accompanying drawing, Fig. 1 is the high level flow chart of the method for forming a body membrane product.The first step
Rapid 10 include forming the mask with hole.Second step 20 include being placed on mask have peelable
In the substrate on surface, this mask has hole.Third step 30 includes that making film-forming composition pass mask passs
Send substrate.4th step 40 includes removing mask.5th step 50 includes by being turned by filmogen
It is melted into a body membrane product to make original-shape solidify.6th step 60 includes the peelable surface from substrate
Remove a body membrane product.This can complete during the manufacture of product and packaging, or can be by consumer
Complete.
Step 10 includes being formed the mask 102 with at least one hole 104, and mask 102 is corresponding to institute
The body membrane product needed (is shown in Fig. 2, hereinafter described).The innovation of the present invention allows shape as required
And simplify or complicate.In an advantage of the invention, shape can be relative complex, should
Plant shape and will produce substantial amounts of trapezoidal waste material in die cut operation.Such as, the printing of nested circle diagram case
During the trapezoidal waste material of minimum that produces be about 20% and (arrange based on the straight line row, column touching quadrant
Circle).
Mask to print is well known in the art.It may include but be not limited to masterplate, silk screen, net
Lattice, band etc..Although the present invention is not critical to by accurately manufacturing of mask to print, but we
Invention makes it can form a body membrane product of relative thick, therefore can use relatively thick mask.Excellent
Selection of land, the thickness of mask is at least about 0.05 millimeter (" mm ").The flexibility on skin,
In one embodiment of the most unnoticed product, the thickness of mask is about 0.05 millimeter to about
0.3 millimeter, more preferably about 0.1 to about 0.2 millimeter.In another embodiment, the one of thickness
Body membrane product can use thickness to be greater than about 0.2 millimeter, elects about 0.2 to about 2 millimeter as, preferably excellently
Ground is about 0.4mm to about 1mm, and the mask system of most preferably about 0.5mm to about 1 millimeter
Become.In many embodiments, the thickness of mask is not critical to, and in other embodiments
In, the invention enables and can form a body membrane product with not previously known thickness.
The thickness of mask generally determines the maximum gauge of a body membrane product.This relation is by film-forming composition
The mechanism of character and said composition solidification determines.Such as, hot melt and hydrophilic colloid film-forming composition lead to
Often produce a kind of product thickness being substantially equal to mask thickness.It is foamed into film composition to be used as,
And can provide and there is the thickness being substantially equal to mask thickness, or even thicker cured film.
Along with product solidifies, solvent or other compositions based on carrier will lose thickness.The reduction of thickness is led to
Often relate to the solids content of compositions.We have found that 30～40% solids content provide thickness
A body membrane product for mask thickness about 50%.The preparation with relatively low solid content may provide tool
Having thickness is the finished product that mask thickness 50% is the least.
Such as, the die board mask thickness of 0.5mm can deposit the original shape of about 0.5mm film-forming composition
Shape.After changing into one film product, solids content based on film-forming composition is subtracted by its thickness
Little.
Different size of mesh opening different application in screen printing process.Grid geometry will
Limit the characteristic of grid.Silk screen grid geometry is straight by grid number and silk thread (or silk or filament)
Footpath limits.The silk thread number of the per inch that grid number comprises in referring to grid.Wire diameter refers to it
It is being made into the diameter before grid.Wire diameter and grid number determine mesh jointly.Mesh is adjacent filaments
Spacing between line.Mesh size determines the maximum particle diameter that can use, and it is thin to affect whole printing
Joint and preparation peel property.For by the optimal film-forming composition passage of grid, the largest particles chi
Very little it is necessarily less than about the 1/3 of mesh.
Some typical sizing grids with relevant hole opening are:
The selection of material is not critical in the mask to print producing the present invention.This area is common
It will be recognized that mask can be made up of structural material, include but not limited to: metal, such as aluminum
Alloy, rustless steel, Ni alloy, Cr alloy etc.；Resin, such as polyimides, polyester, asphalt mixtures modified by epoxy resin
Fat, Merlon, polyethylene, polyethylene terephthalate (PET), polypropylene etc.；Glass；
Paper；Wood；Or cardboard, and combinations thereof.As another example, main body can be by
Composite is made, such as glass fibre filled polyimides, polyester or epoxy resin.Main body
Thin slice is formed as by these materials.The thickness of thin slice can be 20 to 2000 microns (μm), but is just
In processing and otherwise consideration, this thickness is preferably 20 to 80 microns.
In a preferred embodiment, mask has uniform thickness.However, it is possible to use thickness
Degree is along longitudinally varying mask.Such as, mask can have along the central part longitudinally thickeied and tapering point
Portion.
One example of mask according to an embodiment of the invention is the masterplate shown in Fig. 2.This
Mask can be used in flat board plate printing device.In an alternative embodiment, as it is shown on figure 3,
On the surface of the cylinder that mask may be provided at rotary plate printing device.Other modification includes flat bed screen
Mask to print (Fig. 4) and rotary screen mask to print (Fig. 5).
In step 20, mask is placed in the substrate with peelable surface.This peelable surface can
Being endless belt (continuous print flexible flake, link pressing plate etc.), or it can be a piece of peeling liner
Part.Surface can be by using dry lubricant such as molybdenum bisuphide, graphite, tungsten disulfide or this area
Oil known to those of ordinary skill is modified.Typical peel off surface can include silicones, poly-four
Fluorothene (PTFE), wax, polymer, polishing metal, or combinations thereof.Such as Fig. 2-5 above
Shown in, the method can use board device or rotary apparatus.Printing equipment will have for having peelable
From the support member of the substrate on surface, and for by the system (step of mask delivery film-forming composition
30)。
Delivery system generally includes provides the conduit to mask by film-forming composition, and compositions is pushed away
Enter the device of mask hole.Such device include blade-shaped structure (also referred to as cutter, scraper plate, scraper,
Scraping blade, curette etc.), nozzle etc..Blade angle totally determines and compositions is moved in mask hole
With the relative to force applied in substrate.Blade angle (the folder limited by blade and top mask surface
Angle) the flow behavior cooperating with film-forming composition will be optimized to.Angle too small may make cutter
Interface between the top mask surface of sheet and film-forming composition is deficient, and angle is crossed senior general and can not be provided
Be enough to deliver compositions the pressure into mask hole.In one embodiment of the invention, blade angle
Degree preferably less than about 45 °, more preferably about 20 ° to 40 °.The low blade angle of less than about 30 °, more
It is applicable to push more material to fill thicker masterplate.Can also use pressurized nozzles, it is in constant voltage
Lower supply material is to fill masterplate.
In the embodiment of fig. 2, it is shown that simple flat board masterplate system 200, it include for
There is the masterplate (mask of the flat support part 202 of the substrate 204 on peelable surface 206, simple flat
102) and scraper plate 208.In the method, film-forming composition is deposited on mask/base assembly, scraper plate
Scrape and smear film-forming composition and spread all over mask hole, fill by mask and the chamber of base bound.Then, excess
Film-forming composition is removed near mask hole.
(including Fig. 3 A) in the embodiment of Fig. 3, more complicated system 300 includes that masterplate (is covered
Mould 302), it illustrates the outer surface of printing cylinder 304.Film-forming composition is delivered to cylinder by conduit 306
The inside of 304 is also supplied to manifold 308.Manifold 308 has open slot nozzle 310, and it is arranged also
It is configured to when the hole 316 of mask 302 is supported by bed support 318 deliver film-forming composition 312
By mask 302 to substrate 314.Then, it is transmitted through nozzle when mask 302 and substrate 314
When 310, manifold nozzle 310 delivers and scrapes to be smeared film-forming composition 312 and spreads all over mask hole 316, to fill
The chamber limited by mask hole 316 and substrate 314.When mask hole 316 leaves nozzle 310, scraper plate
320 wipe unnecessary film-forming composition off from the upper surface of masterplate (mask 302).Then gained is original
Shape 322 is moved to curing station (not shown), and original-shape is transformed into one film product there
Product.
In the embodiment of fig. 4, the opening masterplate of Fig. 2 is replaced by screen mask.Equally, it is
System 400 includes the simple mask formed on the flat support part 402 for substrate 404, silk screen 408
406, and scraper plate 410.
In the method, film-forming composition is deposited on silk screen 408, and scraper plate 410 is scraped and smeared film forming group
Compound spreads on silk screen 408.Scraper plate 410 forces film forming group relative to the relative motion of silk screen 408
Compound passes silk screen 408.The mask 406 being associated with silk screen 408 define one of required form or
Multiple holes.Equally, the thickness of mask 406 totally limits the thickness of gained one body membrane product and (considers
Some during curing schedule 60 as described below are shunk).Mask 406 arrives due to the pressure contact of scraper plate
Substrate 404 is also formed partially sealed with substrate, to prevent film-forming composition from leaking at required form.
The peelable surface of silk screen 408 and substrate 404 is chosen between film-forming composition and peelable surface
There is provided more than the surface affinity between film-forming composition and silk screen.
Finally, Fig. 5 illustrates another kind of more complicated system 500, and it combines formation on silk screen 504
Mask 502.Mask and silk screen combination are formed in printing cylinder 506.Film-forming composition passes through catheter delivery
To the inside of cylinder 506, and it is delivered to the inner surface of silk screen 504.Blade or scraper plate 508 are by film forming group
Compound is delivered to silk screen 504, is then passed to substrate 510, as above for described by Fig. 4.
Step 40 relates to remove mask.Seeing the system of Fig. 2, once scraper plate 208 is scraped and is smeared film forming group
Compound spreads all over masterplate (mask 102), masterplate (mask 102), then remove from substrate 204, so
After original-shape 210 (being shown in Fig. 6 and 7) is displaced to curing station (not shown), the most original
Shape 210 is converted into a body membrane product 212 (being shown in Fig. 7).As shown in Figure 6A, film forming combination
Thing 214 fills the chamber (as described in Figure 2) limited by mask hole 104 and substrate 204.At masterplate
(mask 102), after substrate 204 removes, original-shape 210 is kept substantially by masterplate (mask
102) shape limited.But, the border of original-shape 210 may change, and this is at this
Within the scope of invention.Such as, the surface tension of Newtonian fluid may cause removing constraint masterplate
The top edge 216 of (mask 102) original-shape 210 afterwards softens into curved edge from right angle, such as figure
Shown in 6B.On the other hand, as shown in Figure 6 C, the top edge 216' of non newtonian compositions can be hard
, it is possible to it is interfered during removing constraint masterplate (mask 102).Therefore, " Wei Shui
Plate " 218 can extend from top edge, so when removing from substrate, some raw material shapes 210' can be with
Masterplate (mask 102) drags together.Alternatively, top edge 216 " can be relative to original-shape
210 " side forms approximate right angle (Fig. 6 D).
In rotary course (as shown in Figure 5), along with substrate 510 is advanced away from printing cylinder 506, former
Beginning shape 512 is rotated away from substrate 510 plane and by cruelly along with the mask 502 on printing cylinder 506 surface
Expose.Equally, original-shape 512 advances to curing station (not shown), there this original shape
Shape 512 is converted into a body membrane product, and this product can remove from the stripping surface of substrate, with independent of base
The end, uses.Rotary course also provides and removes rapidly mask from original-shape.So can improve printing
Quality, because film-forming composition chance of wicking between mask and substrate is less.
In a step 60, a body membrane product removes from the peelable surface of substrate, to make independent of substrate
With.If the method according to the invention uses peeling liner net as substrate, peeling liner net can serve as carrying
Body, and be packaged together with a body membrane product with appropriately sized primary package, until being delivered to consumption
Person.Then, consumer can remove a body membrane product from substrate, and by its required use.Alternative
Ground, if the method according to the invention uses and has the endless belt on peelable surface or other is integrated into system
Substrate on manufacturing apparatus, then a body membrane product is removed and is packed from the peelable surface of substrate for passing
Deliver to consumer.One body membrane product can have adhesive surface, as in medicated plaster or permissible
There is non-sticky surface, as in oral tablet.
For summarizing this method, the most as described above, Fig. 7 A-7E show in section wanting of method
Element.In step 20, the mask 102 with hole 104 is placed in substrate 204 (Fig. 7 A).?
Step 30, mask hole 104 is filled with film-forming composition 214 (Fig. 7 B), and mask 102 is in step
40 are removed, and leave original-shape 210 (Fig. 7 C) in substrate 204.In step 50 (figure
7D), original-shape 210 is cured, and (is shown as molten owing to removing forming a body membrane product 212
Agent, such as water, and there is the thickness of reduction).Finally, by a body membrane product 212 from substrate 204
(Fig. 7 E) removes.
The film-forming composition used in the present invention can be to be the form of hot-melt composition, solid material, can
It is melted to form flowable liquids and deposits to form original-shape, then can cool down to form one
Body film product.Alternatively, film-forming composition can include at least film-forming components and carrier.Annexing ingredient can
Include but not limited to emulsifying agent, surfactant, plasticizer, active component, spice, coloring agent,
Flavoring agent, and other component known to persons of ordinary skill in the art.Carrier is preferably liquid,
And can be solvent or diluent.Preferably carrier includes water and alcohol.
The water-soluble polymer of the present invention has film-forming quality, contributes to manufacturing film of the present invention.
Many water-soluble polymers can be used for the film of the present invention.Representational non-limiting list includes: Pu Lu
Blue, cellulose ether (such as hydroxypropyl methyl cellulose, hydroxyethyl cellulose, hydroxy propyl cellulose
Element), polyvinyl pyrrolidone, carboxymethyl cellulose, polyvinyl alcohol, sodium alginate, poly-second two
Alcohol, Tragacanth, guar gum, acacia gum, Radix Acaciae senegalis, polyacrylic acid, methacrylic acid
Methyl terpolymer, carboxy vinyl polymer, amylose, starch (high amylose starches and hydroxypropylation
High amylose starches) dextrin, pectin, chitin, chitosan, levan, elsinan,
Collagen, gelatin, zein, glutelin, soybean protein isolate, milk surum separation albumen, cheese egg
In vain, and/or their mixture.
In a preferred embodiment, carrier is water.In an alternate embodiment, conventional
The organic solvent used can serve as solvent.The non-limiting list of representativeness of available solvent includes: one
Unit alcohol such as methanol, ethanol, propanol, butanol, MMB and 3-methoxyl group-
N-butyl alcohol；Alkyl carboxylic acid ester's such as methyl-3-methoxyl group and ethyl-3-ethoxy-c；Polyhydric alcohol such as second two
Alcohol, diethylene glycol and propylene glycol；Polyol derivative such as glycol monoethyl ether, ethylene glycol monoethyl ether, second
Glycol monopropyl ether, ethylene glycol monobutyl ether, propylene glycol monomethyl ether, dihydroxypropane single-ether, propylene glycol list third
Ether, propylene glycol monobutyl ether, ethylene glycol monomethyl ether acetate, ethylene glycol monoethylether acetate and propylene glycol
Methyl ether acetate；Fatty acid such as acetic acid and propanoic acid；Ketone such as acetone, methyl ethyl ketone, and 2-heptan
Ketone.These organic solvents can be used alone, or is applied in combination.
Film product also can contain at least one surfactant, including anion, both sexes, nonionic
With cationic surfactant or their mixture.
The non-limiting list of representativeness of anion surfactant includes independent or mixing, followingization
The salt (the most alkali-metal salt, such as sodium salt, ammonium salt, amine salt, amino alcohol or magnesium salt) of compound: alkane
Base sulfate, alkyl ether sulfate, alkylamide ether-sulfate, alkyl aryl polyether-sulfate, list
Sulphate of glyceryl ester, alkylsulfonate, alkylphosphonic, alkylamide sulfonates, alkarylsulphonic acid
Salt, alpha-alkene sulfonate, paraffin sulfonate；Alkyl sulfo succinate, alkyl ether 2-Sulfosuccinic acid
Salt, alkylamide-sulphur, alkylthio succinamate, alkyl sulfobetaines, alkyl ether phosphate, acyl
Base sarcosinate, acyl isethinate and N-acyl taurine salt, such as, have 8 to 24 carbon former
The alkyl of all these various compounds of son or acyl group, and aryl such as phenyl or benzyl.
According at least one embodiment, these salt include fatty acid, such as oleic acid, castor oil acid,
Palmic acid, stearate acid, cocinic acid or hydrogenated coconut oleic acid, acyl group have the acyl of 8～20 carbon atoms
Base lactate, alkyl D-galactoside alduronic acid and their salt and polyoxyalkylene alkyl (C6-
C24) ether carboxylic acid, polyalkylene oxide alkyl (C6-C24) aryl ether carboxylic acid, polyalkylene oxide alkyl (C6-
C24) amido ether carboxylic acid and their salt, such as those have 2 to 50 ethylene oxide groups
, and their mixture.
The non-limiting list of representativeness of amphoteric surfactant includes independent or mixing, secondary or tertiary fat
The derivant of race's amine, wherein aliphatic group is straight chain and side chain, has 8-22 carbon atom and comprises
At least one water-soluble anionic group (such as carboxylate, sulfonate, sulfate, phosphate or phosphonic acids
Salt)；Alkyl (C8-C20) glycine betaine, sulfobetaines, alkyl (C8-C20) amido alkyl
(C1-C6) glycine betaine, such as cocamidopropyl betaine or alkyl (C8-C20) amido alkyl
Base (C1-C6) sulfobetaines.
The non-limiting list of representativeness of nonionic surfactant includes independent or mixing, alcohol, α-
Glycol, alkylphenol or polyethoxy, poly-third or the fatty acid of bound to polyglycerol, have aliphatic chain, example
Such as 8 to 18 carbon atoms, the number of oxirane therein or propylene oxide group can be 2 to 50
Scope is optional, and glyceryl number is optionally in the range of 2 to 30.
In pharmaceutical field, known any plasticizer can be suitable for using at film product.These include but do not limit
In Polyethylene Glycol；Glycerol；Sorbitol；Triethyl citrate；Citric acid tributyl；Decanedioic acid two fourth
Ester；Vegetable oil, such as Oleum Ricini；Surfactant, such as polysorbate, sodium lauryl sulfate
And aerosol OT；Propylene glycol；Glyceryl monoacetate；Glycerine 1,3-diacetate；Glycerol triacetate；
Natural gum and their mixture.
The film product of the present invention also can contain at least one coloring agent, such as pigment or dyestuff.Suitable pigments
Example include but not limited to inorganic pigment, organic pigment, lake, pearlescent pigment, rainbow or
Optically variable pigments, and their mixture.Pigment is understood to refer to inorganic or organically white
Or the granule of colour.Pigment carries out surface process the most within the scope of the invention, but is not limited to
As siloxanes, perfluorochemical, lecithin and aminoacid etc. process.
The present invention can the representative illustration of inorganic pigment include that those are selected from rutile or anatase two
The group of titanium oxide, is encoded to index CI 77891 under color index；Black, yellow, red and brown
Color ferrum oxide, to index CI 77499,77492 and 77491 coding；Manganese violet (CI 77742)；Group
Blue or green (CI 77007)；Chromium oxide (CI 77288)；Chromium hydrate (CI 77289)；And barba hispanica
(CI 77510), and their mixture.
The present invention can organic pigment and the representative illustration of lake include but not limited to that D&C is red
No. 19 (CI 45170), the red No. 21 (CI of red No. 9 of D&C (CI 15585), D&C
45380), D&C orange No. 4 (CI 15510), D&C orange 5 (CI 45370), D&C are red
No. 27 (CI 45410), the red No. 7 (CI of red No. 13 of D&C (CI 15630), D&C
15850), red No. 6 of D&C (CI 15850), D&C yellow No. 5 (CI 19140), D&C are red
No. 36 (CI 12085), D&C orange 10 (CI 45425), the yellow No. 6 (CI of D&C
15985), red No. 30 of D&C (CI 73360), D&C red No. 3 (CI 45430) and based on rouge
The dyestuff of fat worm fuchsin (CI 75570) or lake, and their mixture.
The present invention can the representative illustration of pearlescent pigment include that those are selected from following group: white pearl
Delustering pigment, as scribbled the Muscovitum of titanium dioxide, scribbling the Muscovitum of titanium dioxide, bismuth oxychloride, chlorine oxygen
Changing titanium, color pearly pigment, such as the odenite of band iron oxides, the odenite of band barba hispanica, chromium oxide
Deng, with the odenite of the above-mentioned type organic pigment, and based on bismuth oxychloride those, and they
Mixture.
The exact magnitude of the coloring agent used in the cosmetic composition of the present invention and will depend upon which of type
The color of cosmetic compositions, intensity and purposes, therefore, by the technical staff by cosmetic formulations field
In determine.
Any thickening agent as known in the art may be optionally added in this film.Suitably thickening agent bag
Include but be not limited to cyclodextrin, crystallizable carbohydrate etc., and derivant and combinations thereof.Suitably
Crystallizable carbohydrate includes monosaccharide and oligosaccharide.In monosaccharide, preferably aldohexose (such as Ah
Lip river sugar, altrose, glucose, mannose, gulose, idose, galactose and the D of talose
With L isomer) and ketohexose (D and the L isomer of such as fructose and sorbose) and they
Hydrogenated analogs (such as sorbitol and mannitol).In oligosaccharide, preferably 1,2-bis-sugarcane
Sugar and trehalose, 1,4-disaccharide maltose, lactose and cellobiose, 1,6-disaccharide gentiobiose and honey two
Sugar, and melitriose, together with being referred to as the sucrose isomerase form of isomaltulose, and hydrogenation mould
Intend isomaltulose.Other hydrogenated forms of reduction disaccharide (such as maltose and lactose), such as Fructus Hordei Germinatus
Sugar alcohol and lactose, be also preferred.Additionally, the hydrogenated form of aldopentose: such as, D and L core
Sugar, arabinose, xylose and lyxose, and the hydrogenated form of butanol sugar: such as, the red moss of D and L
And threose, it is suitable, is illustrated by xylitol and erithritol respectively.
Preservative known in the art can be optionally added in this film.Suitably preservative includes but does not limits
In: benzalkonium chloride, benzyl alcohol, 2-bromo-2-nitropropane, butyl p-hydroxybenzoate, hibitane two
Gluconate, siccolam, dehydroactic acid, citric acid, diazonium ureine, DMDM Hydantoin,
Ethylparaben, formaldehyde, imidazolidinyl urea, isobutyl ester, methyl are different, P-hydroxybenzoic acid
Methyl ester, phenoxyethanol, polyaminopropyl biguan-ide, potassium sorbate, propyl p-hydroxybenzoate, quaternary ammonium
Salt-15, salicylic acid, sodium benzoate, dehydroactic acid sodium, sodium pyrosulfite, sodium salicylate, sulfurous acid
Sodium, sorbic acid, stearyl chloride, triclosan, Zinc Pyrithione.
In some embodiments, " microballon " or other granular materials can be combined and be used as " washing
Granule " or " exfoliation granule ", it is used in personal care product and makes in face scrubbing cream and bath gel
Film product.Microballon is little granule, is typically below the particle diameter of about 1000 microns, typically smaller than
About 750 microns.Generally, topical composition and/or skin cleansing compositions mix particle diameter and are less than about 300
Micron and the microballon of preferably less than about 100 microns or granule.Granule, such as Pumex, scope can be 35-
1400 microns；Topical composition generally uses the Pumex of particle diameter about 100 microns.When using screen mask
Time particle diameter should give consideration, because particle diameter is generally less than about the 1/3 of silk screen split shed.For bigger
Grain, uses masterplate to have more advantage, needs to consider because there is silk screen restriction.Microballon can be substantially
Uniform material, and Pumex, polyethylene, glass, aluminium oxide, titanium dioxide, fibre can be included
Dimension element is such as hydroxypropyl methyl cellulose (HPMC) or vitamin E.Alternatively, microballon can be microcapsule
The form of encapsulated particles, it is interior to delay material that one of which material requested is encapsulated in a kind of covering material
The process being discharged in environment.Microencapsulation granule can include the binding agent that is described more fully below and/
Or one or more beneficial agents.
In a preferred embodiment, film-forming composition, such as described in Fig. 6 B, including useful
Agent.One body membrane product 212 of gained has on the peelable surface 206 being formed at substrate 204
One surface 220, and the second surface 222 that its offside is limited by top edge 216.First surface 220
It is arranged and configured into and delivers beneficial agent by it.Such as, first surface 220 can manufacture and storage
During depositing, by consumer's protecting by the peelable backing member in flexible substrates before the use.Separately
On the one hand, second surface 222 is exposed to environmental condition in the solidification process of original-shape 210.Cause
This, first surface 220 can be tacky after substrate 204 removes, such that it is able to adhere to the skin of consumer
On skin.Second surface 222 can be during transforming to a body membrane product 212 " exsiccation ".Cause
This, viscosity first surface 220 is preferable for delivery beneficial agent to consumer skin is upper.
As used by description and claims, term " beneficial agent " and variant thereof are any unit
Element, ion, compound (such as synthesis compound or the compound that separates from natural origin) or other is solid
State ((such as graininess), liquid or the chemical part of gaseous state and skin had beauty treatment or therapeutic effect
Compound.
The compositions of the present invention also can contain one or more beneficial agents or its pharmaceutically useful salt and/or ester,
Described beneficial agent usually with skin reciprocal action, thus obtain the beneficial effect to skin.Such as this
Literary composition is used, and term " beneficial agent " includes can appointing in desired location is delivered to skin and/or on skin
What active component, such as cosmetics or medicine.
Beneficial effect or their hypothesis binding mode is processed according to beneficial agent, can be by available herein
Beneficial agent is classified.It will be appreciated, however, that beneficial agent available herein, in some cases, can carry
Process beneficial effect for more than one or come by more than one binding mode.Therefore, for convenience
For the sake of there is provided herein concrete type, but have no intention beneficial agent is confined to listed concrete application
On.
The suitably example of skin benefit agent includes those of offer beneficial effect, such as but not limited to:
Decolorising agent；Reflective agent；Film forming polymer；Aminoacid and derivant thereof；Antimicrobial；Allergy presses down
Preparation；Anti-acne agents；Antidotal agent；Smoothing wrinkle agent；Preservative；Analgesics；Control oil preparation；Antipruritic
Agent；Local anesthetic；Anti-hair loss agent；Promote hair growth promoter；Hair growth promoting inhibitor；Hydryllin；Infection
Agent；Antiinflammatory；Cholilytic drug；Vasoconstriction medicament；Vasodilation；Wound healing accelerator；
Peptide, peptide and protein；Deodorant and anti-perspirant；Medicament；Skin compacts agent, vitamin；Skin
Brightener；Skin darkening agent；Antifungal；Depilatory；Counterirritant；Hemorrhoid preparation；Insecticide；
For exfoliation or the enzyme of other functional benefit；Enzyme inhibitor；Poison rattan product；Poison Oak Tree
Product；Burn product；Anti-diaper rash agent；Miliaria agent；Vitamin；Plant extract；Vitamin A and
Its derivant；Flavonoid；Perception agents；Antioxidant；Hair lightening agent；Opacifier；Anti-floating swells
Agent, new collagen (neo-collagen) reinforcing agent, film forming polymer, chelating agen；Dandruff/seborrheica
Dermatitis/psoriasis agent；Exfoliator；And their mixture.
Additionally, beneficial agent can also provide passive benefit for skin.Therefore, beneficial agent can be configured to
Compositions, it includes some compositions such as wetting agent or emollient, skin soft agent or conditioner, cosmetic
Preparation, and their mixture.
The suitably example of edema agent includes the hot bisabolol in sky, synthesis opopanax nonexclusively
Alcohol, corticosteroids, glucan and their mixture.
The suitably example of vasoconstrictor includes hippocastanum extract, Pericarpium Zanthoxyli, peroxide nonexclusively
Compound, tetrahydrozoline and their mixture.
The suitably example of antiinflammatory includes benzene ibuprofen, Herba Centellae (centella nonexclusively
Asiatica), bisabolol, chryanthemum parthenium (Herb), chryanthemum parthenium (without parthenolide), green tea
Extract, green tea concentrate, hydrogen peroxide, salicylate, avenol, Chamomile
And their mixture (chamomile).
The example of new collagen enhancer includes that vitamin A and derivant thereof are (such as β-Hu Luo nonexclusively
Bu Su and retinoid such as tretinoin, retinal, retinyl ester, retinyl palmitate, retinol
Ester and retinyl propionate)；Vitamin C and derivant thereof, such as ascorbic acid, sodium ascorbyl phosphate
Ester, ascorbyl palmitate and ascorbic acid glucoside；Copper peptide；Monosaccharide such as lactose, 6-(.alpha.-D-galactosido)-D-glucose. and
Fructose；Mixture with them.
The example of enzyme includes papain, bromelain, pepsin and trypsin.
The suitably example of Firm agent includes alkanolamine, such as dimethylaminoethanol nonexclusively
(“DMAE”)。
The suitably example of pruritus and Derma-Guard includes that oatmeal, β-Portugal gather nonexclusively
(" bean product " refer to the material obtained from Semen sojae atricolor, as special in the U.S. for sugar, chryanthemum parthenium, bean product
Described in profit application 2002-0160062), the heavy carbonate of soda, colloid oatmeal, coloured glaze numerous
In detail, Radix Oenotherae erythrosepalae, Herba Verbenae etc..As used herein, Colloidal oatmeal refers to grind granulate Herba bromi japonici
Grind and be processed further the powder meeting No. 1 and No. 2 American Oats standard obtained.Aveeno Bath
Particle size distribution as follows: in total particle less than 3% its size of granule more than 150 microns, total particle
In less than 20% its size of granule more than 75 microns.Suitably the example of Colloidal oatmeal include but
It is not limited to derive from " Tech-O " of Beacon Corporation (Kenilworth, NJ) and derive from Quaker
The Colloidal oatmeal of (Chicago, IL).
The suitably example of reflective agent includes Muscovitum, aluminium oxide, calcium silicates, ethylene glycol nonexclusively
Dioleate, glycol distearate, silicon dioxide, magnesium fluosilicate sodium and their mixing
Thing.
The example of colour of skin intensifier include nonexclusively dihydroxy acetone, butanone, melanin and it
Mixture.
Suitably film forming polymer includes that those just produce substantially once be dried on skin or finger/toenail
Continuous print coating or the material of film.The suitably example of the nonexcludability of film forming polymer includes acryloyl
Amine hydroxypropyltrimonium chloride/acrylamide copolymer；Corn starch/acrylamide/sodium Acrylate copolymerization
Thing；Polyquaternium-10；Polyquaternary ammonium salt-47；Polyvinyl methyl ethermaleic anhydride copolymer；Styrene/
Acrylate copolymer；And their mixture.
The commercially available wetting agent that can provide moisturizing and conditioning performance includes nonexclusively: (i) water solublity liquid
Body polyhydric alcohol, selected from glycerol, propylene glycol, hexanediol, butanediol, pentanediol, dipropylene glycol and
Their mixture；(ii) poly alkylene glycol of formula HO-(R " O) b--H, wherein R is " for having about 2
To the alkylidene group of about 4 carbon atoms, b is about the integer of 1 to about 10, such as PEG 4；(iii) formula
The polyglycol ether of the methyl glucoside of CH3-C6H10O5-(OCH2CH2) c-OH, wherein c is about
The integer of 5 to about 25；(iv) carbamide；(v) fructose；(vi) glucose；(vii) Mel；(viii) lactic acid；
(ix) maltose；(x) glucuronate sodium；(xi) their mixture, wherein glycerol is exemplary moistening
Agent.
Suitably aminoacid and derivant include the aminoacid of the hydrolysis from various protein and they
Salt, ester and acyl derivative.The example of this amino acid agent includes amphoteric amino acids nonexclusively,
Such as alkylamido alkylamines, i.e. stearyl acetylglutamate, decoyl silkworm silk aminoacid, decoyl
Collagen amino acid；Decoyl Keratin amino acids；Decoyl Semen Pisi sativi aminoacid；Cocodimonium hydroxypropyl
Base silkworm silk aminoacid；Zein powder aminoacid；Cysteine；Glutamic acid；Glycine；Hair angle
Argine Monohydrochloride；Aminoacid, such as aspartic acid, threonine, serine, glutamic acid, dried meat ammonia
Acid, glycine, alanine, cystine, valine, methionine, isoleucine, leucine,
Tyrosine, phenylalanine, cysteic acid, lysine, histidine, arginine, cysteine,
Tryptophan, citrulline；Lysine；Silkworm silk aminoacid, wheat amino acid；And their mixing
Thing.
Suitably protein include those by amino acid whose self condense that formed, there is long-chain (i.e., extremely
Few about 10 carbon atoms) and the polymer of high molecular (i.e., at least about 1000).This proteinoid
The example of nonexcludability include collagen, deoxyribonuclease, iodate zein；Milk egg
In vain；Protease；Serum albumin；Silkworm silk；Semen pruni armeniacae albumen；Wheat germ protein；Wheat protein；α and β
The keratin of spiral；Hair protein, such as intermediate filament protein, High-sulphur protein, ultra-high-sulfur(UHS) albumen, in
Between silk associated protein, high tyrosine protein, high glycine tyrosine protein, trichohyalin and it
Mixture.
The suitably example of vitamin includes various forms of vitamin B complex nonexclusively；Bag
Include thiamine, nicotinic acid, biotin, pantothenic acid, choline, riboflavin, vitamin B3, vitamin
B6, vitamin B12, Benadon, inositol, carnitine；Vitamin A, C, D, E, K and
Derivant, such as vitamin A palmitate and provitamin, such as (that is, pantothenylol (vitamin B5
Former) and panthenyl triacetate)；And their mixture.
Suitably the example of antimicrobial include nonexclusively bacitracin, erythromycin, neomycin,
Tetracycline, chlortetracycline, benzethonium chloride, phenol, benzyl peroxide, slaine or ion as silver and
Its salt, and their mixture.
The suitably example of skin soothing agents and skin moisturizer includes mineral oil, Pilus Caprae seu Ovis nonexclusively
Fat, vegetable oil, isooctadecanol isostearate, glyceryl laurate ester, methyl gluceth-10,
Methyl glucitol polyethers-20 chitosan, and their mixture.
The suitably example of hair soft agent includes silicone compounds nonexclusively, and such as those are non-easily
Volatilization or volatile and those be dissolved in water or water-fast.The suitably example of siloxanes includes
Organic substituted polysiloxanes, it is straight chain or the monomeric circular polymer of monomeric silicone/oxygen, and
It includes cetyl dimethicone nonexclusively；Cetyl triethyl group dimethyl siloxane
Copolymerization phthalic acid ester；Cyclomethicone；Dimethicone copolyol；Dimethyl siloxane
Copolymerization lactic acid；Hydrolysing soybean protein/diformazan copolymeric siloxane acetas；Organosilicon quaternary ammonium salt 13；Firmly
Fat Dimethicone Copolyol phthalic acid ester；Stearic dimethyl siloxane；Mixing with them
Thing.
The example of sunscreen includes benzophenone, bornelone, butyl p-aminophenyl first nonexclusively
Acid, cinnamamide hydroxypropyltrimonium chloride, distyrene diphenyl disulfonate, PABA and
Its derivant (such as, octyldimethyl PABA, butylmethoxydibenzoylmethane, methoxy
Base isoamyl cinnamate, octyl methoxycinnamate, camphanone benzene come methyl, methoxy cinnamic acid monooctyl ester,
Oxybenzone, octocrylene, ethylhexyl salicylate, homosaligenin, phenylbenzimidazol
Sulfonic acid, ethyl hydroxypropyl base Aminobenzoate, Antisolaire, amino benzoic Acid, west
Promise sand ester, diethanolamine methoxy base cinnamate, glyceryl aminobenzoate, titanium dioxide, oxidation
Execute over peaceful S and SX of zinc, oxybenzone, padimate O, red petrolatum, barley green, sky M and
S, and their mixture.
The example of skin lightening agent includes hydroquinone, catechol and derivant thereof, Vitamin C nonexclusively
Acid and derivant and their mixture.
The suitably example of insecticide (including that insect repellants, anti-scabies and anti-louse process) is non-exclusive
Property ground include Permethrin, pyrethrin, piperonyl butoxide, imidacloprid, N, N-diethyltoluene formyl
Amine, this material referring to mainly contain meta-isomer, i.e. N, N-diethyl-m-toluyl
Amine, it is also referred to as DEET, naturally occurring or synthetic pyrethroid, the most natural pyrethroid bag
It is contained in Pyrethrum, the ground connection flower extract of Herba et Flos Pyrethri Cinerariifolii or Flos Pyrethri coccinei；Mixing with them
Thing.Being ethyl 3-(N-butyl acetamido) propionic ester in the structure of formula III, wherein R7 is CH3 base
Group, R5 is normal-butyl epoxide, and R6 is H, and K is COOR8, and R8 is ethyl, and it is purchased from
Merck KGaA (Darmstadt, Germany), entitled " anophelifuge 3535 ".
The example of antifungal foot preparation includes tolnaftate and myconozole nonexclusively.
The suitably example of depilatory includes calcium mercaptoacetate, TGA magnesium, sulfydryl nonexclusively
Potassium acetate, TGA strontium and their mixture.
Suitably analgesic, such as external-use analgesic and local anesthetic, example wrap nonexclusively
Include benzocaine, dibucaine, benzylalcohol, Camphora, capsaicin, Fructus Capsici, capsicum resin oil, Juniperus rigida Sieb.et Zucc.
Oil, menthol, methyl nicotinate, methyl salicylate, phenol, resorcinol, turpentine oil and they
Mixture.
The suitably example of antiperspirant and deodorizer includes aluminium chlorohydrate, chloride hydrate nonexclusively
Aluminum zirconium and their mixture.
Suitably the example of counterirritant include nonexclusively Camphora, menthol, methyl salicylate,
Mentha arvensis L. syn.M.haplocalyxBrig and Oleum Caryophylli, ichthyol (ichtammol) and their mixture.
The example suitably pressing down scorching agent includes hydrocortisone, wild strawberry (Fragaria nonexclusively
Vesca), Flos Matricariae chamomillae (Matricaria Chamomilla) and Salvia japonica Thunb. (Salvia Officinalis).
The suitably example of the medicinal component of anesthesia includes benzocaine, hydrochloric acid Pu Moka nonexclusively
Cause, lignocaine, betaeucaine and their mixture；Preservative, such as benzethonium chloride；Receive
Hold back agent, such as zinc oxide, bismuth subgallate, Peruvian balsam and their mixture；Skin is protected
Protect agent, such as zinc oxide, silicone oil, vaseline, cod liver oil, vegetable oil and their mixing
Thing.
Effectively related indication this type of is suitable for treatment of dandruff, seborrheic dermatitis and Corii Bovis seu Bubali moss machine
The example of beneficial agent include the such as sulfonation of ZPT, anthralin, shale oil and derivant thereof nonexclusively
Shale oil, selenium sulfide, sulfur；Salicylic acid；Coal tar；Povidone iodine, imidazoles such as ketoconazole, two
Chlorphenyl imidazoles dioxolanes (" elubiol "), clotrimazole, itraconazole, miconazole, chlorine miaow bar
Azoles, tioconazole, sulconazole, butoconazole, fluconazol, miconazole nitrate and any possible solid
Isomer and derivant thereof；Piroctone amine (Octopirox)；Ciclopirox olamine；Antipsoriatic
Such as novel vitamin D analogues, such as calcipotriol, calcitriol and tacalcitol；Retinoid is seemingly
The ester of thing such as vitamin A, such as vitamin A palmitate and vitamin A acetate, vitamin A
Propionic ester, axerophthal, retinol and tretinoin；Corticosteroid, such as hydrocortisone,
Clobetasone, butyrate, clobetasol propionate, menthol, Pramoxine HCL and theirs is mixed
Compound.
The example of the beneficial agent being suitable to hair growth includes but not limited to: potassium channel openers or peripheral blood
Enlargement of pipe agent such as minoxidil, diazoxide, and such as N*-cyano group-N-(tertiary pentyl)-N'-3-pyridine radicals-guanidine
Compounds such as (" P-1075 ")；Saw Palmetto P.E, vitamin, such as vitamin E and vitamin
C, and their derivant such as vitamin e acetate and sodium L-ascorbate-2-phosphate；Hormone, as
Erythropoietin, prostaglandin, such as PGE1 and prostaglandin F2-α；Fatty acid, example
Such as oleic acid；Diuretic such as spironolactone；Heatshock protein (' HSP "), such as HSP 27 and HSP 72；
Calcium channel blocker, such as verapamil hydrochloric acid, nifedipine, diltiazem amiloride；Immunity presses down
Preparation medicine, such as cyclosporin and FK-506；5α-reductase inhibitor such as finasteride；Somatomedin
Such as EGF, IGF and FGF；Transforming growth factor β；Tumor necrosis factor；Nonsteriodal anti-inflammatory,
Such as Benoxaprofen；Retinoid such as retinal and retinoic acid；Cytokine, such as IL-6, IL-1 α and
IL-1β；Cell adhesion molecule such as ICAM；Glucocorticoid such as betamethasone；Plant extract, as
Aloe, Flos Caryophylli, Radix Ginseng, Radix Rehmanniae Preparata, Herba Swertiae bimaculatae, Fructus Citri sinensis, Pericarpium Zanthoxyli, Saw Palmetto Berries (Serenoa repens), non-
Continent Rhizoma Solani tuber osi, Herba Urticae Cannabinae, Semen Cucurbitae and rye pollen；Other plant extract, including Lignum Santali Albi, red sweet
Dish root, chrysanthemum, Herba Rosmarini Officinalis, the natural on-off cycles of hair growth such as Fructus Arctii promotes activating agent；Take advantage of a situation agent such as potassium phosphate D2, print
Degree margosa D2 and jaborandi DI；The base of cytokine, somatomedin and male baldness
Cause；Antifungal, such as ketoconazole and Xin Kang azoles；Antibiotic such as streptomycin；Protein inhibitor, as put
Line bacterium ketone；Acetazolamide；Benzene ibuprofen；Cortisone；Diltiazem；Perchlorobenzene；Hydantoin；Nitre
Benzene Horizon；Penicillamine；Phenothiazine；Skin Nahsi；Psoralen, verapamil；Zidovudine；Have
The α of at least one in following rutin-glucose rutin: Quercetin, isoquercitrin, Hesperidin, Pericarpium Citri grandis
Glycosides and hesperidin methyl, flavonoid and transglucosidase derivant thereof；Mixture with them.
The example of the beneficial agent being suitable for hair growth inhibition includes: serine protease such as Trypsin
Enzyme；Vitamin such as alpha-tocopherol (vitamin E) and derivant thereof, such as tocopherol acetas and fertility
Phenol cetylate；Antitumor agent, such as doxorubicin, cyclophosphamide, chlormethine, methotrexate, fluorine urine
Pyrimidine, vincristine, daunorubicin, bleomycin and hydroxyurea；Anticoagulant, such as heparin, class
Heparin, coumarin, dextran and indandione；Antithyroid drug, as iodine, thiouracil and
Carbimazole；Lithium and lithium carbonate；Interferon, such as interferon-ALPHA, Intederon Alpha-2a and Interferon Alpha-2b；
Retinoid, such as retinol (vitamin A), isotretinoin: glucocorticoid, such as betamethasone
And dexamethasone；Blood lipid-lowering medicine, such as triparanol and clofibrate；Thallium；Hydrargyrum；Albendazole；Not
Purine alcohol；Amiodarone；Amphetamine；Androgen；Bromocriptine；Butyrophenone；Carbamazepine；Disappear gallbladder
Amine；Cimetidine；Clofibrate；Danazol；Desipramine；Dixyrazine；Ethambutol；Second sulfur
Isoniazid；Fluoxetine；Gentamycin, gold salt；Hydantoin；Ibuprofen；Miboplatin is bright；Immunity ball
Albumen；Indandione；Indomethacin；Itraconazole；Levodopa；Maprotiline；Ergota is new
Alkali；Metoprolol；Metopirone；Nadolol；Nicotinic acid；Potassium thiocyanate；Propranolol；Pyridine this
Bright；Salicylate；Sulfasalazine；Teldane；Thiamphenicol；Thiouracil；Front three
Diketone；Triparanol；Valproic acid；Mixture with them.
The suitably example of defying age reagent includes but not limited to inorganic sunscreen, such as titanium dioxide and
Zinc oxide；Organic sunscreens, such as octyl methoxycinnamate and derivant thereof；Retinoid；Contain
Copper peptide；Vitamin (such as vitamin E, vitamin A, vitamin C and vitamin B) and spreading out
Biology, such as vitamin e acetate, vitamin C palmitate；Antioxidant includes β trailing plants recklessly
Bu Su；Alpha-hydroxy acid such as glycolic, citric acid, lactic acid, malic acid, mandelic acid, ascorbic acid, α-
Hydroxybutyric acid, alpha-hydroxybutyric dehydrogenase, Alpha-hydroxy isocaproic acid, atrolactinic acid, Alpha-hydroxy isovaleric acid, acetone acid
Ethyl ester, galacturonic acid, glucoheptonic acid, glucoheptonic acid-1,4-lactone, gluconic acid, gluconic acid
Lactone, glucuronic acid, glucuronolactone, glycolic, acetone acid isopropyl ester, acetone acid first
Ester, glactaric acid, acetone acid, glucosaccharic acid, saccharic acid-1,4-lactone, tartaric acid and hydroxymalonic acid；β-water
Poplar acid, such as beta-hydroxy-butanoic acid, beta phenyllactic acid and beta-phenyl acetone acid；Polyphenols；Plant extract
Thing, such as green tea, soybean prod, Silybum marianum Gaertn, Sargassum, Aloe, Radix Angelicae Sinensis, Citrus aurantium Linn., coffee, Huang
Company, grapefruit, hoellen, Flos Lonicerae, Semen Coicis, Radix Arnebiae (Radix Lithospermi), Fructus Mori, Radix Paeoniae, Radix Puerariae, big
Rice, Flos Carthami and mixture thereof.
The suitably example of anti-acne agents includes but not limited to: external retinoic acid (retinoic acid, isotretinoin first
Acid, motretinide, adapalene, tazarotene, Azelaic Acid, retinol)；Salicylic acid；Peroxide
Change benzoyl；Resorcinol；Antibiotic such as tetracycline and their isomer, erythromycin and antiinflammatory
Agent such as ibuprofen, naproxen, ketoprofen；Plant extract such as drought, arnica montana, Herba Artemisiae Scopariae, Herba Asari
Root, birch, Flos Inulae, Flos Matricariae chamomillae, Fructus Cnidii, Radix Arnebiae (Radix Lithospermi), Fructus Foeniculi, Galla Chinensis, Fructus Crataegi, fish raw meat
Grass, Radix Hyperici Monogyni (Herba Hyperici Monogyni), Fructus Jujubae, Fructus actinidiae chinensis, Radix Glycyrrhizae, Drymotaenium miyoshianum (Mak.) Mak., Fructus Canarii albi, Mentha arvensis L. syn.M.haplocalyxBrig, climing green floss, pellet
Join, red birch is voluminous, VC.Aureomariginatn；Imidazoles such as ketoconazole and Xin Kang azoles.
The example of suitable depigmenting agent includes but not limited to soybean prod；Retinoid (such as regards Huang
Alcohol)；Kojic acid and derivant (such as Kojic Acid Dipalmitate) thereof；Hydroquinone and derivant thereof
(such as arbutin)；Tranexamic acid；Vitamin (such as nicotinic acid, vitamin C and derivative
Thing)；Azelaic Acid；placertia；Radix Glycyrrhizae；Extract (such as Chamomile and green tea) and with conduct
The mixture of the retinoid of the example being particularly suitable, kojic acid, soybean prod and hydroquinone.
Suitably controlling hemorrhoid prevents the example of product from including but not limited to anesthetis, such as benzocaine, salt
Acid pramocaine and their mixture；Preservative, such as benzethonium chloride；Astringent, such as oxygen
Change zinc, bismuth subgallate, Peruvian balsam and their mixture；Derma-Guard, such as cod
Cod-liver oil, vegetable oil and their mixture.
The example of vasodilator includes but not limited to minoxidil, diazoxide and such as N*-cyano group-N-(uncle
Amyl group) compound such as-N'-3-pyridine radicals-guanidine (" P-1075 ").
The suitably example of gloss controlling agent includes but not limited to hydrated SiO 2, Kaolin and swelling
Soil.Suitably antihistamine drug's example includes but not limited to diphhydramine hydrochloride.
The suitably example of anti-infective includes but not limited to benzalkonium chloride, primoline and peroxidating
Hydrogen.The suitably example of Wound-healing agent includes but not limited to chitosan and derivant thereof.Close
Suitable poison ivy and the example of poison oak products include but not limited to bentonite, hydrocortisone, Herba Menthae
Alcohol and lignocaine.The suitably example of burn product includes but not limited to benzocaine and benefit card
Cause.The example of suitable anti-diaper rash product includes but not limited to: zinc oxide and vaseline.Suitably
The example of miliaria product includes but not limited to: zinc oxide.The suitably example of sensory agent includes but does not limits
In menthol, aromatic and citric acid.
The beneficial agent being particularly suited for the present invention includes DMAE, soybean prod, colloidal state nonexclusively
Oatmeal, sulfonation shale oil, Folium olive, Dichlorobenzene base imidazoles dioxolanes (elubiol), 6-(1-piperazine
Piperidinyl)-2,4-thonzylamine-3-oxide, finasteride, ketoconazole, oxybenzoic acid, pyrrole sulfur
Zinc, coal tar, benzoyl peroxide, selenium sulfide, hydrocortisone, sulfur, menthol, hydrochloric acid are general
Not caine, three cetyl ammonia chlorides, polyquaternary ammonium salt 10, pantothenylol, panthenyl triacetate, vitamin A
And derivant, vitamin B and derivant thereof, vitamin C and derivant thereof, vitamin D and
Derivant, vitamin E and derivant thereof, vitamin K and derivant thereof, keratin, lysine,
Arginine, hydrolyzed wheat protein, copper-containing compound, such as peptide and mantoquita, hydrolyzed silkworm silk albumen, first
Epoxide cinnamic acid monooctyl ester, oxybenzone, avobenzone, minoxidil, Serenoa repens extract, dioxy
Change titanium, zinc oxide, retinol, erythromycin (erthromycin), tretinoin (tretinoin) and
Their mixture.
Other beneficial agent can include new Collagen Promotor (such as retinoid such as retinal and cupric
Peptide), skin-tightening agent (such as DMAE) and decolorising agent (such as soy sauce).
Available beneficial agent content may penetrate the energy of skin or fingernail according to (such as) beneficial agent
Power, selected concrete beneficial agent, required concrete beneficial effect, the user sensitivity to beneficial agent
The situation of degree, user health status, user age and user skin and/or fingernail etc. and have
Institute is different.In a word, beneficial agent uses with the principle of " safe and effective amount ", and this dosage up to be enough to
Reach required to skin or the beneficial effect of fingernail, or change certain condition of illness to be treated, but should
Dosage the most as little as be enough to avoid serious side effects, to provide reasonably in the range of rational medical judgment
Effective hazard ratio.
Beneficial agent can become assignment system with other, mix or be combined into a kind of compositions (such as liquid,
Emulsion, cream, etc.), wherein other composition does not detracts because of the functional of beneficial agent.Strengthen skin
Can prepare to meet this merit together with beneficial agent to the delivery agents of the absorption of one or more beneficial agents
Energy.Suitably delivery agents includes such as, sulfoxide, alcohols such as ethanol；Fatty acid is such as, such as, sub-oily
Acid or oleic acid, fatty acid ester, e.g., for example, it is possible to by a C3-C10 carboxylic acid and C10-C20 fat
Alcohol reacts and prepares；Polyhydric alcohol, alkane, amine, amide, terpenes, surfactant, cyclodextrin or
Known in the art it be suitable for strengthening various beneficial agent and penetrate through horny layer and enter other of deep skin
Reagent or a combination thereof.
The concentration of the beneficial agent in said composition is variable.Unless represented otherwise herein, the most useful
Agent can amount based on composition/system gross weight about 0.01% to about 20% exist, and described amount is e.g.
About 0.01% to about 5% (such as, about 0.01% to about 1%).
The compositions comprising beneficial agent can also be used as coupling systems compound as discussed previously, and can wrap
Include and make said composition have one of them some compositions of these functions.
In addition or replace one or more said components, aromatic, flavoring agent, sweeting agent, coloring
Agent, pigment, dyestuff etc. can join in the film-forming composition of the present invention.
Embodiment
To understand that the present invention, described embodiment are to produce by referring to an embodiment in detail below more step
The exemplary embodiment of the composition of apparatus of the present invention, form and method.Should be appreciated that the described dress of production
The multiple modification of composition, form and the method put will be apparent to one skilled in the art
's.Below example, wherein parts and percentages is by weight, except as otherwise noted, only
It is illustrative.
Prepared by % solid and viscosity number in film-forming composition list below 1:
Table 1
1Viscosity in terms of centipoise (cP) the Brookfield viscosity meter calibrated.Test method is standardized as:
Temperature 70 (21 DEG C)
Main shaft #RV S06
Motor speed: 20rpm.
2Screen printing ink for test is by Speedball Art Products, LLC, 2301 Speedball Road,
Statesville, NC 28677 USA manufacture, solid % content not record.
The stencilization of embodiment 1-18
Masterplate material: plastic spacer raw material, is cut out by laser profile, substrate polyethylene coating paper
(The original bleaching of freezing packing paper #S7045.40 pound, one side scribbles 5 pounds of polyethylene, can be from
Uline, Pleasant Prairie, Wisconsin, USA buy).
Masterplate by hand, completes with flat condition, supports with smooth plate glass, carries 4 inches wide
Hard scraper (be similar to putty knife and/or dry wall instrument can substitute for blade)
Film-forming composition in table 1 there are five use scraper and have the masterplate of thickness in lower list 2
Deposition.One body membrane product of gained is dried, removes from substrate, and measures.
Table 2
| Embodiment # | Formula | Masterplate thickness (inch) | Masterplate thickness (mm) | Average dry thickness3(inch) |
| 1 | 1 | 0.005 | 0.13 | 0.002 |
| 2 | 1 | 0.007 | 0.18 | 0.002 |
| 3 | 1 | 0.010 | 0.25 | 0.003 |
| 4 | 1 | 0.020 | 0.51 | 0.005 |
| 5 | 1 | 0.030 | 0.76 | 0.007 |
| 6 | 1 | 0.040 | 1.02 | 0.011 |
| 7 | 2 | 0.005 | 0.13 | 0.003 |
| 8 | 2 | 0.007 | 0.18 | 0.003 |
| 9 | 2 | 0.010 | 0.25 | 0.004 |
| 10 | 2 | 0.020 | 0.51 | 0.007 |
| 11 | 2 | 0.030 | 0.76 | 0.011 |
| 12 | 2 | 0.040 | 1.02 | 0.014 |
| 13 | 3 | 0.005 | 0.13 | 0.004 |
| 14 | 3 | 0.007 | 0.18 | 0.005 |
| 15 | 3 | 0.010 | 0.25 | 0.006 |
| 16 | 3 | 0.020 | 0.51 | 0.009 |
| 17 | 3 | 0.030 | 0.76 | 0.015 |
| 18 | 3 | 0.040 | 1.02 | 0.019 |
3The meansigma methods of the maximum and minimum value of two film products being individually dried.
These results are drawn by a curve chart (Fig. 8), the figure shows masterplate thickness and formula 1-3
Cured film between linear relationship.
Embodiment 19-34 silk screen printing
Use rotary module silk-screen printing device (Fig. 3), with the cylinder diameter of 5 inches.Outside Tong
Surface is to be limited by the nickel wire net (40 × 40 mesh (perforate/inch)) of 0.003 inch, and has table 3
The middle mask determining (0.010 to 0.030 inch) thickness is formed on the inner surface of grid.Film forming group
Compound is placed in substrate, such as embodiment 1-30 (polyethylene coating paper).Result is shown in
In table 3.
Table 3
4The meansigma methods of the maximum and minimum value of (six) two film products being individually dried.
These results are drawn by a curve chart (Fig. 9), the figure shows masterplate thickness and one film
Between linear relationship.These data include formula 1-3, and the formula 6 and 7 combined respectively, because
Solid % content is considered as essentially identical, and gained desciccator diaphragm thickness is for given mask thickness base
It is identical in basis.
The description of description above and embodiment is to aid in intactly and without limitation understanding this
Literary composition disclosed invention.Without departing from the spirit and scope of the present invention, can be made this
Bright many variations and implementations, therefore the present invention is limited by claims appended below.
Claims (11)
1. the method forming a body membrane product, comprises the following steps:
A. the mask with at least one hole is placed in the substrate with peelable surface, described at least
One hole has the shape corresponding to a required body membrane product；
B. film-forming composition is delivered by least one hole described of described mask, with on the substrate
Form the original-shape corresponding at least one hole described；
C. described mask is removed；
D. make described original-shape change into and be arranged on a described suprabasil described body membrane product；Wherein
A described body membrane product is arranged and configured into can be from the described peelable surface of described substrate
Remove, in order to use independent of described substrate.
Method the most according to claim 1, wherein said mask is disposed in the rotating cylinder with inside
Cylindrical surface on, and the described internal flow of at least one hole described and described rotating cylinder
Connection.
Method the most according to claim 1, wherein said mask has and spreads all at least one hole described and set
The silk screen put.
Method the most according to claim 3, wherein said film-forming composition is through the scraper plate of described silk screen
There is the blade angle between about 20 ° and about 40 °.
Method the most according to claim 4, wherein described film-forming composition is delivered by nozzle under stress
To described mask.
Method the most according to claim 1, wherein said mask is masterplate.
Method the most according to claim 6, wherein described film-forming composition is delivered by nozzle under stress
To described mask.
Method the most according to claim 1, wherein said original-shape has at least about 0.5mm's
Thickness.
9. the method forming a body membrane product, comprises the following steps:
A. the mask with at least one hole is placed in the substrate with peelable surface, described at least
One hole has the design corresponding to a required body membrane product；
B. the film-forming composition comprising beneficial agent is delivered by least one hole described of described mask, with
Form the original-shape corresponding at least one hole described on the substrate；
C. described mask is removed；
D. make described original-shape change into and be arranged on a described suprabasil described body membrane product, wherein
A described body membrane product has first surface, and described first surface is arranged and configured into can
Remove from the described peelable surface of described substrate, in order to use independent of described substrate, and
And wherein said beneficial agent can be delivered by the described first surface of a described body membrane product.
10. the body membrane product including method according to claim 1 and make.
11. 1 kinds of body membrane products including method according to claim 9 and make.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361922287P | 2013-12-31 | 2013-12-31 | |
| US61/922,287 | 2013-12-31 | ||
| PCT/US2014/072098 WO2015103029A1 (en) | 2013-12-31 | 2014-12-23 | Process for forming an integral film product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105873567A true CN105873567A (en) | 2016-08-17 |
Family
ID=52424108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480071882.9A Pending CN105873567A (en) | 2013-12-31 | 2014-12-23 | Process for forming an integral film product |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20150182991A1 (en) |
| EP (1) | EP3091963A1 (en) |
| JP (1) | JP2017510474A (en) |
| KR (1) | KR20160105840A (en) |
| CN (1) | CN105873567A (en) |
| AU (1) | AU2014374103A1 (en) |
| CA (1) | CA2935188A1 (en) |
| MX (1) | MX2016008676A (en) |
| RU (1) | RU2016131305A (en) |
| WO (1) | WO2015103029A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108081527A (en) * | 2017-09-22 | 2018-05-29 | 纳智源科技（唐山）有限责任公司 | It is used to prepare the preparation method of the mold of polymer membrane, the preparation method of polymer membrane and friction generator |
| CN111284074A (en) * | 2020-02-21 | 2020-06-16 | 王超锋 | Processing system and process for individualized patterns on surface of corrugated paper package |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2700870C2 (en) | 2013-12-31 | 2019-09-23 | Джонсон энд Джонсон Консьюмер Инк. | Method of forming film product |
| WO2015103030A1 (en) | 2013-12-31 | 2015-07-09 | Johnson & Johnson Consumer Companies, Inc. | Process for forming a multi layered shaped film |
| KR20160140810A (en) * | 2014-03-28 | 2016-12-07 | 마그넷노우츠, 리미티드 | Rotary process for application of magnetic compositions |
| US10821297B2 (en) * | 2016-09-30 | 2020-11-03 | Johnson & Johnson Consumer Inc. | Kit and method for topical delivery of benefits |
| US10596134B2 (en) | 2017-02-08 | 2020-03-24 | Johnson & Johnson Consumer Inc. | Compositions and methods for treating skin conditions using light and polycarboxylic acids |
| CN111698984B (en) * | 2018-03-19 | 2023-11-14 | 宝洁公司 | Method for preparing barrier patch with soluble film |
| US11241374B2 (en) | 2018-06-28 | 2022-02-08 | Johnson & Johnson Consumer Inc. | Compositions and methods for treating skin conditions using light and glucosamine hydrochloride |
| GB201904400D0 (en) * | 2019-03-29 | 2019-05-15 | Trio Healthcare Ltd | Screen printing apparatus and method |
| US20200405603A1 (en) | 2019-06-25 | 2020-12-31 | Johnson & Johnson Consumer Inc. | Compositions and methods for treating skin conditions using infrared light and resorcinols |
| US10537534B1 (en) | 2019-06-25 | 2020-01-21 | Johnson & Johnson Consumer Inc. | Compositions and methods for treating skin conditions using visible light and resorcinols |
| WO2024074910A1 (en) * | 2022-10-07 | 2024-04-11 | 3M Innovative Properties Company | Biocidal composition |
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2016131305A3 (en) | 2018-06-29 |
| CA2935188A1 (en) | 2015-07-09 |
| US20150182991A1 (en) | 2015-07-02 |
| EP3091963A1 (en) | 2016-11-16 |
| WO2015103029A1 (en) | 2015-07-09 |
| MX2016008676A (en) | 2017-03-08 |
| JP2017510474A (en) | 2017-04-13 |
| KR20160105840A (en) | 2016-09-07 |
| AU2014374103A1 (en) | 2016-07-07 |
| RU2016131305A (en) | 2018-02-05 |
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