CN114699494A - Antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream and preparation method thereof - Google Patents
Antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream and preparation method thereof Download PDFInfo
- Publication number
- CN114699494A CN114699494A CN202210361012.1A CN202210361012A CN114699494A CN 114699494 A CN114699494 A CN 114699494A CN 202210361012 A CN202210361012 A CN 202210361012A CN 114699494 A CN114699494 A CN 114699494A
- Authority
- CN
- China
- Prior art keywords
- weight
- parts
- cream
- traditional chinese
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/483—Gleditsia (locust)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8884—Arisaema, e.g. Jack in the pulpit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/904—Stemonaceae (Stemona family), e.g. croomia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/55—Liquid-liquid separation; Phase separation
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Insects & Arthropods (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicinal cream with antibacterial, anti-inflammatory and antipruritic effects is mainly prepared from Chinese medicinal components and cream matrix, wherein the Chinese medicinal components are mainly prepared from typhonium giganteum, gallnut, spina gleditsiae, cortex pseudolaricis, cortex dictamni, lithospermum, fructus kochiae, honeysuckle, wild chrysanthemum flower, golden cypress, radix stemonae, rhizoma smilacis glabrae, sarcandra chinensis, ilex pedunculata, radix euphorbiae lantu, radix sophorae flavescentis, borneol, menthol and fructus cnidii. The antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream can clear heat, dry dampness, dispel wind, kill parasites and relieve itching, can effectively improve or even eliminate clinical symptoms of patients with skin diseases, and has the characteristics of natural medicine application, remarkable treatment effect, short treatment period, no toxic or side effect and the like.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine cream with effects of inhibiting bacteria, diminishing inflammation and relieving itching and a preparation method thereof.
Background
The skin is the first physiological defense line and the largest organ of the human body, the abnormal condition of the organism can be reflected on the surface of the skin, and the skin diseases can be caused when the physiological function of the skin is damaged. Skin diseases are of a wide variety and diseases occurring in various internal organs may also manifest themselves on the skin. Common skin diseases are: psoriasis (psoriasis), eczema, prurigo, lichen, skin pruritus, pityriasis, dermatitis, rhagadia manus et pedis, tinea capitis, tinea manuum, tinea pedis, tinea corporis, tinea versicolor, dermatomyositis, etc. The skin diseases are caused by a plurality of reasons, some skin diseases are also communicable, and the skin diseases not only affect the body health of the people, but also can easily cause panic and discrimination of other people.
At present, medicines for treating skin diseases are mainly focused on single disease treatment, the treatment mode is high in pertinence, one skin disease can be accurately cured, but the medicines are not suitable for other skin diseases, and the conditions of various skin diseases encountered in life of people cannot be met. In order to meet the requirement, hormone external-use ointment also appears on the market, but the medicines are western medicine components, contain a large amount of hormone, can quickly achieve the effect of healing, but cannot improve the condition of the skin for a long time. The drug is easy to generate dependence after long-term use, can cause allergy, causes the skin of an affected part to be dry, rough and desquamated, even has shallow and fine cracks, aggravates the condition of skin itch, is not suitable for whole body or large-area application, is difficult to control the recurrence of skin diseases, and can generate larger side effects after long-term use of the drug containing hormone, for example, the children adopt the hormone drug to generate adrenal hyperfunction syndrome, increase calcium loss, induce other skin diseases and the like. Moreover, the Chinese patent medicines on the market at present have no products with excellent curative effect, and have undefined treatment indications and poor effect.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a traditional Chinese medicine cream for inhibiting bacteria, diminishing inflammation and relieving itching and a preparation method thereof.
In order to solve the technical problems, one of the technical solutions provided by the present invention is:
a Chinese medicinal cream with antibacterial, anti-inflammatory and antipruritic effects is mainly prepared from Chinese medicinal components and cream matrix, wherein the Chinese medicinal components are mainly prepared from typhonium giganteum, gallnut, spina gleditsiae, cortex pseudolaricis, cortex dictamni, lithospermum, fructus kochiae, honeysuckle, wild chrysanthemum flower, golden cypress, radix stemonae, rhizoma smilacis glabrae, sarcandra chinensis, ilex pedunculata, radix euphorbiae lantu, radix sophorae flavescentis, borneol, menthol and fructus cnidii.
Preferably, the traditional Chinese medicine components are mainly prepared from 4-10 parts by weight of typhonium giganteum, 3-10 parts by weight of gallnut, 3-10 parts by weight of spina gleditsiae, 10-30 parts by weight of golden larch bark, 5-10 parts by weight of dittany bark, 10-15 parts by weight of lithospermum, 9-15 parts by weight of belvedere fruit, 9-35 parts by weight of honeysuckle flower, 12-18 parts by weight of wild chrysanthemum flower, 7-13 parts by weight of golden cypress, 6-12 parts by weight of radix stemonae, 10-60 parts by weight of glabrous greenbrier rhizome, 10-15 parts by weight of pterocephalus chinensis, 15-35 parts by weight of ilex pedunculata, 2-5 parts by weight of radix euphorbiae lantu, 5-11 parts by weight of radix sophorae flavescentis, 0.15-0.3 part by weight of borneol, 3-6 parts by weight of menthol and 4-10 parts by weight of fructus cnidii.
Preferably, the traditional Chinese medicine composition is mainly prepared from 5 parts by weight of typhonium giganteum, 10 parts by weight of gallnut, 9 parts by weight of spina gleditsiae, 28 parts by weight of golden larch bark, 9 parts by weight of cortex dictamni, 15 parts by weight of lithospermum, 14 parts by weight of belvedere fruit, 30 parts by weight of honeysuckle, 15 parts by weight of wild chrysanthemum flower, 10 parts by weight of golden cypress, 11 parts by weight of radix stemonae, 50 parts by weight of rhizoma smilacis glabrae, 14 parts by weight of pterocephalus chinensis, 34 parts by weight of ilex rotundus, 4.5 parts by weight of radix euphorbiae lantu, 10 parts by weight of radix sophorae flavescentis, 0.15 part by weight of borneol, 5 parts by weight of menthol and 9 parts by weight of fructus cnidii.
Preferably, the cream base comprises 8.5% of vaseline, 12% of stearic acid, 7% of glyceryl monostearate, 0.1% of ethylparaben, 1% of sodium lauryl sulfate, 10% of glycerol and the balance of water in percentage by mass.
The second technical scheme provided by the invention is as follows:
the preparation method of the antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream comprises the following steps:
(1) cleaning herba Typhonii gigantei, Galla chinensis, spina Gleditsiae, cortex pseudolaricis, cortex Dictamni, radix Arnebiae, Kochiae fructus, flos Lonicerae, flos Chrysanthemi Indici, cortex Phellodendri, radix Stemonae, rhizoma Smilacis Glabrae, herba Pteridis Multifidae, radix Ilicis Pubescentis, radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, and fructus Cnidii, air drying, pulverizing, and sieving with 50-100 mesh sieve to obtain medicinal powder;
(2) adding 6-8 times of distilled water into the traditional Chinese medicine powder prepared in the step (1), soaking for 12-24 hours, then decocting, and filtering the decoction to obtain a medicine extracting solution;
(3) adding an ethanol solution into the medicine extracting solution obtained in the step (2), and soaking and extracting;
(4) repeating the soaking and extracting in the step (3), combining the liquid medicine, filtering, and concentrating the liquid medicine to obtain the extract of the traditional Chinese medicinal materials;
(5) and (3) heating and uniformly mixing the traditional Chinese medicine extract obtained in the step (4) and the cream substrate, adding borneol and menthol when the temperature of the mixture is reduced to be below 40 ℃, and obtaining the traditional Chinese medicine cream.
Preferably, in the step (3), the concentration of the ethanol solution is 70-90%, the addition amount of the ethanol solution is 10-15 times of the medicine extract, and the soaking extraction time is 0.5-2 h.
Preferably, in the step (5), the mass ratio of the traditional Chinese medicine extract to the cream matrix is 1-3: 1.
Preferably, in step (5), the cream base is prepared by the following preparation method: heating and melting vaseline, stearic acid, glyceryl monostearate and ethylparaben to prepare a uniform oil phase; mixing sodium lauryl sulfate, glycerol and distilled water to obtain water phase, heating to 80 deg.C, adding into oil phase, and making into cream matrix.
The invention relates to a bacteriostatic, anti-inflammatory and antipruritic traditional Chinese medicine cream which is mainly prepared from typhonium giganteum, Chinese gall, spina gleditsiae, golden larch bark, cortex dictamni, lithospermum erythrorhizon, belvedere fruit, honeysuckle, wild chrysanthemum flower, golden cypress, radix stemonae, rhizoma smilacis glabrae, seven-star sword, ilex rotundus, radix euphorbiae lantu, radix sophorae flavescentis, borneol, menthol and fructus cnidii. Borneol: has the effects of inducing resuscitation, refreshing mind, clearing heat, removing toxic substances, improving eyesight, removing nebula, eliminating odor, killing parasites, relieving itching, removing putrefaction, and promoting tissue regeneration. Fructus cnidii: dispelling pathogenic wind, removing dampness, killing parasites and relieving itching, and can be used for treating eczema, scabies, tinea and pruritus. Golden larch bark: killing parasites and relieving itching, and can be used for treating tinea corporis, tinea pedis, scabies, eczema, and neurodermatitis. Typhonium giganteum: dispel wind and stop spasm, remove toxicity and resolve masses, dry dampness and resolve phlegm. Lithospermum: cool blood and activate blood, remove toxicity and promote eruption. Seven-star sword: has effects of inducing sweat, relieving summer-heat, promoting diuresis, and removing toxic substance, and can be used for treating chronic skin eczema, pruritus, and wind phlegm sore. The preparation method comprises the following steps of (1) preparing broom cypress fruit: clearing heat and drying dampness, dispelling wind and relieving itching, and is mostly used for skin rubella, eczema, pruritus all over. Cortex dictamni: clearing heat, eliminating dampness, dispelling pathogenic wind, removing toxic substance, and can be used for treating toxic heat wind, aversion to wind, sore, scabies, tinea, scabies, and red rot, and has obvious effects in relieving itching and resisting allergy. Flavescent sophora root: the external traditional Chinese medicine composition is bitter and cold in nature, has the effects of clearing heat, eliminating dampness, killing parasites and relieving itching, also has the effects of resisting bacteria, diminishing inflammation and viruses, reducing skin damage and effectively inhibiting the growth of germs, is commonly used for treating eczema, skin pruritus, mange and leprosy, trichomonas vaginitis and the like in clinic, and has good curative effect. Cortex meliae: killing parasite, and treating tinea, and can be used for treating ascariasis, ancylostomiasis, enterobiasis, trichomoniasis vaginalis, scabies, and tinea capitis. Galla chinensis is externally used for arresting sweating and bleeding, astringing dampness and healing wound. Radix Stemonae can kill parasites and kill louse, and can be used for treating head louse, body louse, and enterobiasis; radix euphorbiae ebracteolatae: disperse pathogen accumulation and kill parasites, and is externally used for skin itch, psoriasis and the like, and modern researches find that the externally used medicine also has good antibacterial and antiviral effects. Glabrous greenbrier rhizome, wild chrysanthemum flower and honeysuckle flower: has heat-clearing, detoxicating, antibacterial and antiinflammatory effects, and can also be used for treating carbuncle and scabies. Menthol, which is used as an irritant in medicine, acts on the skin or mucous membrane to cool and relieve itching. Heat-clearing herbs are usually combined with toxicity-counteracting, parasites-killing, dampness-drying and itching-relieving herbs, so cnidium fruit is often combined with Ku Shen, Bai Xian Pi, Huang Bai and Smilax glabra to achieve the effects of clearing heat, removing dampness, killing parasites, relieving itching, promoting blood circulation and removing toxicity.
The antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream has good antibacterial and antipruritic effects, and particularly, asiatic acid in borneol can play a role in treating skin diseases such as acne, burn, atopic dermatitis, wounds and the like in vitro and in vivo through NF-kappa B, TGF-beta/Smad, MAPK, Wnt/beta-catenin and STAT signal conduction; the osthole can be used for repairing skin barrier and inhibiting Akt pathway to exert antiinflammatory and antipruritic effects, and can be used for treating skin diseases such as skin pruritus and eczema; the golden larch bark has certain antibacterial effect on 10 common pathogenic dermatophytes in China, the main antifungal components comprise organic acid, ethanol extract and benzene extract, and the main antifungal components can quickly relieve the symptoms of pruritus, discomfort and the like of a patient through the synergistic effect of the raw materials, prevent the recurrence of the rash and have low recurrence rate; the cortex dictamni extract ketone has anti-inflammatory activity, can relieve inflammatory reaction triggered by macrophage stimulated by lipopolysaccharide, and has the action mechanism of inhibiting NF-kB, reducing mRNA and protein expression of iNOS and cox-2, reducing NO generation and prostaglandin synthesis, reducing cell damage and generating anti-inflammatory action by reducing phosphorylation of IKK and ERK1/2 (extracellular regulated protein kinase) in the macrophage; the saponin Ic and its aglycone oleanolic acid in Kochiae fructus are effective components for relieving itching, resisting inflammation and inhibiting I type allergy, and the action mechanism is that Kochiae fructus methanol extract remarkably inhibits the release of inflammatory transmitters such as tumor necrosis factor alpha (TNF-alpha), prostaglandin E2 (PGE2) and Nitric Oxide (NO) induced by Lipopolysaccharide (LPS). The traditional Chinese medicine composition is supported by pharmacological effects, borneol is aromatic, avoids dirt, dispels evil, kills worms and relieves itching, removes putrefaction and promotes tissue regeneration, cortex pseudolaricis is used as a monarch drug to play a main antibacterial effect, cortex dictamni, fructus kochiae and fructus cnidii are commonly and effectively matched with the drugs for killing parasites and relieving itching to enhance the efficacy of killing parasites and relieving itching, and the traditional Chinese medicine composition is used as a ministerial drug to remarkably increase the treatment effect, has the efficacy of killing bacteria and resisting inflammation, repairing skin, regulating skin immunity and resisting skin aging, and can effectively prevent and treat dermatitis, eczema, tinea manus, tinea pedis, tinea corporis, folliculitis and other symptoms.
Compared with the prior art, the invention has the advantages that:
the antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream can clear heat, dry dampness, dispel wind, kill parasites and relieve itching, can effectively improve or even eliminate clinical symptoms of patients with skin diseases, and has the characteristics of natural medicine application, remarkable treatment effect, short treatment period, no toxic or side effect and the like.
Detailed Description
In order to facilitate an understanding of the present invention, the present invention will be described more fully and in detail with reference to the preferred embodiments, but the scope of the present invention is not limited to the specific embodiments described below.
Unless otherwise defined, all terms of art used hereinafter have the same meaning as commonly understood by one of ordinary skill in the art. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention.
Unless otherwise specified, the reagents and materials used in the present invention are commercially available products or products obtained by a known method.
Example (b):
the traditional Chinese medicine cream is mainly prepared from 5 parts by weight of typhonium giganteum, 10 parts by weight of Chinese gall, 9 parts by weight of spina gleditsiae, 28 parts by weight of golden larch bark, 9 parts by weight of cortex dictamni, 15 parts by weight of lithospermum, 14 parts by weight of belvedere fruit, 30 parts by weight of honeysuckle, 15 parts by weight of wild chrysanthemum flower, 10 parts by weight of golden cypress, 11 parts by weight of radix stemonae, 50 parts by weight of glabrous greenbrier rhizome, 14 parts by weight of pterocephalus chinensis, 34 parts by weight of iron holly root, 4.5 parts by weight of radix euphorbiae lantu, 10 parts by weight of radix sophorae flavescentis, 0.15 part by weight of borneol, 5 parts by weight of menthol and 9 parts by weight of fructus cnidii.
The preparation method of the bacteriostatic, anti-inflammatory and antipruritic traditional Chinese medicine cream comprises the following steps of:
(1) cleaning herba Typhonii gigantei, Galla chinensis, spina Gleditsiae, cortex pseudolaricis, cortex Dictamni, radix Arnebiae, Kochiae fructus, flos Lonicerae, flos Chrysanthemi Indici, cortex Phellodendri, radix Stemonae, rhizoma Smilacis Glabrae, herba Pteridis Multifidae, radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, and fructus Cnidii, air drying at room temperature, pulverizing with micronizer, and sieving with 100 mesh sieve to obtain Chinese medicinal powder;
(2) adding distilled water 7 times the amount of the traditional Chinese medicine powder prepared in the step (1), soaking for 18 hours, then decocting for 3 times, each time for 1 hour, and filtering the decoction to obtain a medicine extracting solution;
(3) adding 12 times of 70% ethanol solution into the medicinal extractive solution, soaking for one hour, extracting repeatedly for 1 time, mixing medicinal liquids, filtering, and concentrating to obtain extract of Chinese medicinal materials;
(4) heating vaseline, stearic acid, glyceryl monostearate and ethylparaben to melt to prepare a uniform oil phase; preparing water phase from sodium laurylsulfate, glycerol and distilled water, heating to 80 deg.C, adding into oil phase, and making into cream matrix;
(5) heating, mixing and stirring the extracts of the traditional Chinese medicinal materials and the cream matrix for 15 minutes according to the mass ratio of 2:1 to prepare cream;
(6) adding Borneolum (dissolved in 95% ethanol) and Mentholum (dissolved in 95% ethanol) when the temperature of the cream is reduced to below 40 deg.C, and making into traditional Chinese medicinal cream.
Irritation test and allergy test
The hair of the back of 30 mice was cut off, and the Chinese medicinal cream prepared in the examples was applied to the cut-off part and the non-coated part, respectively, to compare them, and as a result, no irritation or allergic reaction was observed.
A proper amount of the cream prepared in the example is applied to the hand of a volunteer (16-65 years old and 25 persons), and no redness, rash or scar appears after 20 minutes.
Effect on itch caused by histamine phosphate test:
experimental methods and grouping: 36 Kunming mice, each half of male and female, were randomly divided into 3 groups, which were a model control group, a positive control group (compound dexamethasone acetate emulsion), and an execution group (coated with the traditional Chinese medicine cream of example 1).
On the day before the experiment, the mouse neck and back were depilated for 2cm x 3cm, the skin of the right hind paw and back of the mouse was polished with fine sand paper, until the skin became red and bleeding did not occur, after 24 hours, 50 μ L of histamine phosphate 0.02% was dropped on the polished skin, and the number of itching and duration of the mouse within 15min were immediately observed and recorded. The indication of itching is that the back instep skin is once itchy and recorded after the mice lick back to gnaw.
The cream is smeared on the skin of the back foot of a mouse right, the cream is gently and instantly absorbed, a model is made after 30min, the times of licking the body and the reaction duration of the licking body within 15min are observed and recorded, the difference between groups is compared, and the result is shown in table 1.
TABLE 1 antipruritic effect of antibacterial antipruritic cream on pruritus caused by histamine phosphate
Note: in comparison with the set of models,** P<0.01
histamine is an important transmitter which can cause skin itch, and the characteristics of skin lesion, pathology, immunity and the like of a mouse are consistent with the characteristics of ectopic skin lesion of a human after the mouse is stimulated by antigen under a common environment. Therefore, compared with the model group, the positive control group and the experimental group have obviously reduced skin itch times through experiments (P<0.01), the duration of cutaneous pruritus is obviously shortenedP<0.01), the results show that the antibacterial itching-relieving cream has obvious effect of treating skin itch. Although the itching relieving effect of the traditional Chinese medicine cream is slightly poor compared with that of hormone compound dexamethasone acetate emulsion, the pure traditional Chinese medicine cream is natural in medicine, free of toxic and side effects and easy to control recurrence of skin diseases.
Case 1:
when a certain person is aged for 19 years, women and ulnar sides of upper limbs suffer from eczema for 2 years, the clinical manifestations of eczema are pimple, herpes dungholicus, weeping, scabbing and the like, and the cream is treated by various external medicines once, the effect is not obvious, and the cream for inhibiting bacteria and relieving itching is used, and is coated on affected parts for 3 times every day, and possible allergic and irritant foods such as hot peppers, strong tea, coffee and wines are avoided. The symptoms are relieved within 24h, the rash is completely eliminated after 2 months, and the rash does not relapse after half a year of follow-up visit.
Case 2:
the antibacterial antipruritic traditional Chinese medicine cream is used for uniformly coating the antibacterial antipruritic traditional Chinese medicine cream on an affected part two to three times a day, and a patient keeps to frequently change and wash close-fitting clothes such as underpants, bed sheets and the like. The groin is often cleaned. The vagina and the thighs are kept dry and clean, the symptoms are relieved within 24h, the tinea cruris symptoms are eliminated after 2 months, and the tinea cruris does not relapse after one follow-up visit.
Case 3:
in 67 years old, female is diagnosed with senile pruritus and subjective general pruritus, but the following limbs are most obvious, the pruritus is especially severe before falling asleep at night, the paroxysmal pruritus is generally observed, the persistent pruritus is serious, the paroxysmal pruritus is aggravated, and the patients sometimes cannot tolerate the pruritus. The antibacterial itching-relieving cream is uniformly applied to the affected part of the lower limb, the itching symptom is relieved within 24 hours, and the itching symptom of the lower limb is eliminated within 2 months.
Case 4:
liu is a certain disease, male is 43 years old, psoriasis is diagnosed, back neck plaque is accompanied by pruritus for 1 year, paroxysmal pruritus is perceived, repeated scratching is caused, usually, due to local irritation, mental dysphoria is aggravated, skin damage and common scratch or blood scab around the skin damage are caused, a patient is diagnosed with a prescription western medicine ointment, the symptom is not obviously improved, the patient uses the bacteriostatic itching-relieving pure traditional Chinese medicine ointment of the invention, the bacteriostatic itching-relieving pure traditional Chinese medicine ointment is uniformly smeared on an affected part two to three times a day, the advice is kept for sufficient sleep and good mood, irritation is avoided, spicy food is eaten less, the pruritus symptom is relieved after 2 days, and the pruritus symptom is eliminated after 2 months.
Claims (9)
1. The traditional Chinese medicine cream is characterized by being mainly prepared from traditional Chinese medicine components and a cream substrate, wherein the traditional Chinese medicine components are mainly prepared from typhonium giganteum, gallnut, spina gleditsiae, golden larch bark, cortex dictamni, lithospermum, belvedere fruit, honeysuckle flower, wild chrysanthemum flower, golden cypress, radix stemonae, rhizoma smilacis glabrae, seven-star sword, ilex rotundus, radix euphorbiae lantu, radix sophorae flavescentis, borneol, menthol and fructus cnidii.
2. The bacteriostatic, anti-inflammatory and antipruritic traditional Chinese medicine cream as claimed in claim 1, the traditional Chinese medicine composition is mainly prepared from 4-10 parts by weight of typhonium giganteum, 3-10 parts by weight of gallnut, 3-10 parts by weight of spina gleditsiae, 10-30 parts by weight of golden larch bark, 5-10 parts by weight of cortex dictamni, 10-15 parts by weight of lithospermum, 9-15 parts by weight of fructus kochiae, 9-35 parts by weight of honeysuckle, 12-18 parts by weight of wild chrysanthemum flower, 7-13 parts by weight of golden cypress, 6-12 parts by weight of radix stemonae, 10-60 parts by weight of glabrous greenbrier rhizome, 10-15 parts by weight of esculentus, 15-35 parts by weight of iron holly, 2-5 parts by weight of radix euphorbiae lantu, 5-11 parts by weight of radix sophorae flavescentis, 0.15-0.3 part by weight of borneol, 3-6 parts by weight of menthol and 4-10 parts by weight of fructus cnidii.
3. The antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream as claimed in claim 2, wherein the traditional Chinese medicine components are mainly prepared from 5 parts by weight of typhonium giganteum, 10 parts by weight of gallnut, 9 parts by weight of spina gleditsiae, 28 parts by weight of golden larch bark, 9 parts by weight of cortex dictamni, 15 parts by weight of lithospermum, 14 parts by weight of belvedere fruit, 30 parts by weight of honeysuckle flower, 15 parts by weight of wild chrysanthemum flower, 10 parts by weight of golden cypress, 11 parts by weight of radix stemonae, 50 parts by weight of glabrous greenbrier rhizome, 14 parts by weight of aesculus chinensis, 34 parts by weight of ilex chinensis, 4.5 parts by weight of radix euphorbiae lantu, 10 parts by weight of radix sophorae flavescentis, 0.15 parts by weight of borneol, 5 parts by weight of menthol and 9 parts by weight of fructus cnidii.
4. The bacteriostatic, anti-inflammatory and antipruritic traditional Chinese medicine cream according to any one of claims 1 to 3, wherein the cream matrix comprises the following components in percentage by mass: 8.5% of vaseline, 12% of stearic acid, 7% of glyceryl monostearate, 0.1% of ethylparaben, 1% of sodium dodecyl sulfate, 10% of glycerol and the balance of distilled water.
5. The preparation method of the bacteriostatic, anti-inflammatory and antipruritic traditional Chinese medicine cream as claimed in any one of claims 1 to 4, which is characterized by comprising the following steps:
(1) cleaning herba Typhonii gigantei, Galla chinensis, spina Gleditsiae, cortex pseudolaricis, cortex Dictamni, radix Arnebiae, Kochiae fructus, flos Lonicerae, flos Chrysanthemi Indici, cortex Phellodendri, radix Stemonae, rhizoma Smilacis Glabrae, herba Pteridis Multifidae, radix Ilicis Pubescentis, radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, and fructus Cnidii, air drying, pulverizing, and sieving with 50-100 mesh sieve to obtain Chinese medicinal powder;
(2) adding 6-8 times of distilled water into the traditional Chinese medicine powder prepared in the step (1), soaking for 12-24 hours, then decocting, and filtering the decoction to obtain a medicine extracting solution;
(3) adding an ethanol solution into the medicine extracting solution obtained in the step (2), and soaking and extracting;
(4) repeating the soaking and extracting in the step (3), combining the liquid medicine, filtering, and concentrating the liquid medicine to obtain the extract of the traditional Chinese medicinal materials;
(5) and (3) heating and uniformly mixing the traditional Chinese medicine extract obtained in the step (4) and the cream substrate, adding borneol and menthol when the temperature of the mixture is reduced to be below 40 ℃, and obtaining the traditional Chinese medicine cream.
6. The preparation method according to claim 5, wherein in the step (3), the concentration of the ethanol solution is 70% -90%, the addition amount of the ethanol solution is 10-15 times of the drug extract, and the soaking extraction time is 0.5-2 h.
7. The preparation method according to claim 5, wherein in the step (5), the mass ratio of the Chinese medicinal material extract to the cream base is 1-3: 1.
8. The method of claim 5, wherein in the step (5), the cream base is prepared by the following method: heating and melting vaseline, stearic acid, glyceryl monostearate and ethylparaben to prepare a uniform oil phase; mixing sodium lauryl sulfate, glycerol and distilled water to obtain water phase, heating to 80 deg.C, adding into oil phase, and making into cream matrix.
9. The preparation method according to claim 5, wherein in the step (2), the number of times of decoction is 3 for 1 hour each time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210361012.1A CN114699494A (en) | 2022-04-07 | 2022-04-07 | Antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210361012.1A CN114699494A (en) | 2022-04-07 | 2022-04-07 | Antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114699494A true CN114699494A (en) | 2022-07-05 |
Family
ID=82172359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210361012.1A Pending CN114699494A (en) | 2022-04-07 | 2022-04-07 | Antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114699494A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114177252A (en) * | 2021-12-06 | 2022-03-15 | 吴玉宝 | Anti-bacterial ointment for Arabrother and preparation method thereof |
| CN115414450A (en) * | 2022-09-19 | 2022-12-02 | 江西中科佰氏药业有限公司 | A topical skin antibacterial cream containing multiple Chinese medicinal materials and its preparation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079644A (en) * | 2015-10-03 | 2015-11-25 | 成都倍加特生物科技有限公司 | Poultice capable of effectively treating tinea manus and pedis and preparation method thereof |
| CN105233112A (en) * | 2015-10-25 | 2016-01-13 | 四川双鑫生物科技有限公司 | Paste medicine treating neurodermatitis and preparation method thereof |
| CN105327049A (en) * | 2014-08-06 | 2016-02-17 | 刘海燕 | Cortex pseudolaricis dermatitis ointment and preparation method thereof |
| CN111450212A (en) * | 2020-05-21 | 2020-07-28 | 泓麟生物科技(广州)有限公司 | A Chinese medicinal composition for treating tinea pedis and tinea, and preparation method thereof |
-
2022
- 2022-04-07 CN CN202210361012.1A patent/CN114699494A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327049A (en) * | 2014-08-06 | 2016-02-17 | 刘海燕 | Cortex pseudolaricis dermatitis ointment and preparation method thereof |
| CN105079644A (en) * | 2015-10-03 | 2015-11-25 | 成都倍加特生物科技有限公司 | Poultice capable of effectively treating tinea manus and pedis and preparation method thereof |
| CN105233112A (en) * | 2015-10-25 | 2016-01-13 | 四川双鑫生物科技有限公司 | Paste medicine treating neurodermatitis and preparation method thereof |
| CN111450212A (en) * | 2020-05-21 | 2020-07-28 | 泓麟生物科技(广州)有限公司 | A Chinese medicinal composition for treating tinea pedis and tinea, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 丽丽等: ""火箭队"抑菌乳膏治疗压疮的效果观察", 《吉林医学》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114177252A (en) * | 2021-12-06 | 2022-03-15 | 吴玉宝 | Anti-bacterial ointment for Arabrother and preparation method thereof |
| CN115414450A (en) * | 2022-09-19 | 2022-12-02 | 江西中科佰氏药业有限公司 | A topical skin antibacterial cream containing multiple Chinese medicinal materials and its preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Maver et al. | A review of herbal medicines in wound healing | |
| US6027728A (en) | Herbal skin regeneration composition and method | |
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN103041173B (en) | Traditional Chinese medicine external preparation for curing dermatitis and eczema and preparing method thereof | |
| CN114699494A (en) | Antibacterial, anti-inflammatory and antipruritic traditional Chinese medicine cream and preparation method thereof | |
| CN109453353B (en) | Moxibustion essential oil and preparation method thereof | |
| CN102579701B (en) | Compound dandelion decoction | |
| CN111743986A (en) | Gynecological gel and preparation method thereof | |
| CN105169339A (en) | Traditional Chinese medicine cleaning fluid for treating gynecologic inflammation | |
| CN110652552A (en) | Wound healing formula and preparation method | |
| CN105194270A (en) | Traditional Chinese medicine ointment for treating skin diseases | |
| CN107998242A (en) | A kind of Chinese medicine composition for treating mastitis for milk cows and preparation method thereof | |
| CN107536937B (en) | A topical Chinese medicinal liquid for treating dermatoses and onychomycosis, and its preparation method | |
| CN113181336A (en) | Traditional Chinese medicine composition and preparation for treating gynecological diseases and preparation method and application thereof | |
| CN100488543C (en) | Local externally applied itch stopping garlic liniments | |
| Muniandy et al. | The action of Coleus aromaticus as a potential wound healing agent in experimentally induced diabetic mice | |
| CN108295023B (en) | Traditional Chinese medicine toothpaste and preparation method thereof | |
| CN105456957A (en) | Traditional Chinese medicine composition for treating bromhidrosis | |
| CN104623304A (en) | Lotion for treating chronic skin ulcer caused by damp-heat and toxicity accumulation and preparation method of lotion | |
| CN116747286B (en) | A Chinese medicinal composition with weight reducing effect, and its preparation method | |
| CN103432565A (en) | Gynaecological antiphlogistic and analgesic pharmaceutical formulation | |
| CN107951972A (en) | Apply medicinal lotion or ointment outside a kind of Chinese traditional medicine composition for treating mastitis for milk cows thing and preparation method thereof | |
| CN105640279A (en) | Quisqualis indica health care carpet | |
| CN104906515A (en) | Traditional Chinese medicine composition for treating stenocardia and preparation method thereof | |
| CN105691257A (en) | Negative ion mosquito repellent type headrest of automobile seat and automobile seat using headrest |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |