CN105327049A - Cortex pseudolaricis dermatitis ointment and preparation method thereof - Google Patents

Abstract

The invention discloses cortex pseudolaricis dermatitis ointment and a preparation method thereof. The cortex pseudolaricis dermatitis ointment is prepared from main components and an auxiliary component, wherein the main components are as follows by weight: 40-50 g of cortex pseudolaricis, 30-40 g of radix sophorae flavescentis, 35-40 g of fructus cnidii, 30-36 g of fructus kochiae, 25-28 g of dittany bark, 30-40 g of radix euphorbiae lantu, 33-36 g of spina gleditsiae, 30-40 g of typhonium giganteum, and 50-60 g of Ilex rotunda Thunb.. The auxiliary component is 500-800 g of albolene. The cortex pseudolaricis dermatitis ointment is prepared through the steps of heat extraction, concentration, spray drying and mixed preparation. The prepared cortex pseudolaricis dermatitis ointment has the fungi killing rate 19 times higher than that of the common western medicine, and has the functions of killing fungi within a short time and inhibiting the fungi for a long term; the cortex pseudolaricis dermatitis ointment is applied to the infected part of the foot for 1-2 times each day, the curative effects can be achieved after the cortex pseudolaricis dermatitis ointment is applied for three days continuously, the dermatitis curing rate achieves 98%, the treatment cycle is short, the relapse of dermatitis seldom occurs, the cortex pseudolaricis dermatitis ointment has relatively strong inhibition, sterilization and disinfection functions for staphylococcus, candida and escherichia coli infected by the skin allergy and the acute and chronic eczematous dermatitis caused by various bacteria and fungi, can prevent skin infection, and has remarkable effects for obstinate itches and tinea symptoms.

Description

A kind of Cortex Pseudolaricis dermatitis plaster and preparation method thereof

Technical field

The present invention relates to the technical field of Chinese medicinal ointment, espespecially a kind of Cortex Pseudolaricis dermatitis plaster and preparation method thereof.

Background technology

The pathogenic factor of dermatitis and eczema is very complicated, is simply divided into intrinsic factor and extrinsic factor, and difficult point primary and secondary, normally interknits, synergism therebetween.Exopathogenic factor as chemicals, cosmetics, zootoxin, fish and shrimp, pollen, dust, Exposure to Sunlight, scratch.Endogenous cause of ill comprises the immune factor, metabolic factor etc. of inherited genetic factors, Nervous and Mental Factors, body.The impact of psychological factor on dermatitis and eczema more and more comes into one's own, the generation of dermatitis and eczema also may that certain relation be had to treat the method for dermatitis and eczema be a lot of with diet, rule of life, environment etc., but it is low mostly to there is cure rate, the weak points such as the treatment phase is long, easy recurrence.Cortex Pseudolaricis is Cortex Pseudolaricis again, and containing organic acid, ethanol extract and benzene extractum, the 10 kind pathomycetes common to China all have certain antibacterial action; Cortex Pseudolaricis also has the effect that significant anti-tumor neovascularization is formed, and antitumor action, antifertility action, blood vessel formation against function, antifungic action, Pseudolarix acid B can peroxide activator proliferator-activated receptor.Cortex Pseudolaricis has Anti-Puritic and insecticidal, and for trick tinea, neurodermatitis, eczema, leprosy dysentery head, all has the inhibitory action of higher degree to dermatophytes, if Cortex Pseudolaricis is used for the treatment of dermatitis and eczema, will reach the effect of getting twice the result with half the effort.

Summary of the invention

A kind of Cortex Pseudolaricis dermatitis plaster of the present invention and preparation method thereof, Cortex Pseudolaricis, Radix Sophorae Flavescentis, Fructus Cnidii, the Fructus Kochiae, Cortex Dictamni, the Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae), Spina Gleditsiae, Herba Typhonii gigantei, Ilex rotunda Thunb. is adopted to be raw material, carry through hot dipping, concentrate, spraying dry, the processing step that is mixed with, realize object prepared by Cortex Pseudolaricis dermatitis plaster

To achieve these goals, technical solution of the present invention is: the major ingredient component of a kind of Cortex Pseudolaricis dermatitis plaster and preparation method thereof: Cortex Pseudolaricis 40g ~ 50g, Radix Sophorae Flavescentis 30g ~ 40g, Fructus Cnidii 35g ~ 40g, Fructus Kochiae 30g ~ 36g, Cortex Dictamni 25g ~ 28g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 30g ~ 40g, Spina Gleditsiae 33g ~ 36g, Herba Typhonii gigantei 30g ~ 40g, Ilex rotunda Thunb. 50g ~ 60g;

Adjuvant component: white vaseline 500g ~ 800g;

Technique preparation process is as follows:

(1) hot dipping is carried: by the remove impurity of major ingredient component, cleaning, oven dry, pulverizing, inserts in jacketed pan and adds 6 times of water gagings, and temperature 100 DEG C ~ 110 DEG C lixiviate 1h, get lixiviating solution and deposit; Add 6 times amount flooding 1h again, merge twice lixiviating solution, use 100 mesh screen;

(2) concentrate: filtrate is inserted in vacuum concentration pan, setting vacuum 97kPa, temperature 55 DEG C ~ 70 DEG C, be condensed into concentrated solution, concentrated solution is 25% of major ingredient component;

(3) spraying dry: spray dryer setting inlet temperature is 125 DEG C, leaving air temp is 85 DEG C, pressure is 80Moa, wind speed is 0.85m3/min, carries out hot-air spray drying and obtains mixed powder;

(4) be mixed with: add adjuvant component in a kettle., adjustment kettle temperature 60 C ~ 65 DEG C, stir, more slowly add mixed powder, uniform stirring 30min, both obtain paste finished product.

The present invention is through clinical research, more than 19 times are exceeded than the killing rate of conventional western medicine to fungus, there is the long-acting inhibition of short-term killing action, is applied to skin affected part 1 ~ 2 time its every day, smear 3 days continuously, heal dermatitis rate can reach 98%, and treatment cycle is short, not easily recur, to various antibacterial, fungus-caused skin allergy, acute and chronic dermatitis and eczema, tinea manus and pedis skin pruritus, pruritus ani and skin infection, mosquito bite, miliaria, hemorrhoid, blister, tinea capitis, tinea corporis and cruris, tinea versicolor, pityriasis alba, the staphylococcus that urticaria etc. infect, candidiasis escherichia coli have stronger suppression, sterilization, disinfective action also can prevent skin infection, remarkable result is had to obstinate pruritus and tinea card.

Detailed description of the invention

Embodiment 1

(1) component:

1. major ingredient component: Cortex Pseudolaricis 40g, Radix Sophorae Flavescentis 30g, Fructus Cnidii 35g, Fructus Kochiae 30g, Cortex Dictamni 25g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 30g, Spina Gleditsiae 33g, Herba Typhonii gigantei 30g, Ilex rotunda Thunb. 50g;

2. adjuvant component: white vaseline 500g;

(2) technique preparation process:

1. hot dipping is carried: by the remove impurity of major ingredient component, cleaning, oven dry, pulverizing, inserts in jacketed pan and adds 6 times of water gagings, and temperature 100 DEG C ~ 110 DEG C lixiviate 1h, get lixiviating solution and deposit; Add 6 times amount flooding 1h again, merge twice lixiviating solution, use 100 mesh screen;

2. concentrate: filtrate is inserted in vacuum concentration pan, setting vacuum 97kPa, temperature 55 DEG C ~ 70 DEG C, be condensed into concentrated solution, concentrated solution is 25% of major ingredient component;

3. spraying dry: spray dryer setting inlet temperature is 125 DEG C, leaving air temp is 85 DEG C, pressure is 80Moa, wind speed is 0.85m3/min, carries out hot-air spray drying and obtains mixed powder;

4. be mixed with: add adjuvant component in a kettle., adjustment kettle temperature 60 C ~ 65 DEG C, stir, more slowly add mixed powder, uniform stirring 30min, both obtain paste finished product.

Embodiment 2

(1) component:

1. major ingredient component: Cortex Pseudolaricis 45g, Radix Sophorae Flavescentis 5g, Fructus Cnidii 38g, Fructus Kochiae 33g, Cortex Dictamni 27g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 35g, Spina Gleditsiae 34g, Herba Typhonii gigantei 35g, Ilex rotunda Thunb. 55g;

2. adjuvant component: white vaseline 700g;

(2) technique preparation process:

1. hot dipping is carried: by the remove impurity of major ingredient component, cleaning, oven dry, pulverizing, inserts in jacketed pan and adds 6 times of water gagings, and temperature 100 DEG C ~ 110 DEG C lixiviate 1h, get lixiviating solution and deposit; Add 6 times amount flooding 1h again, merge twice lixiviating solution, use 100 mesh screen;

2. concentrate: filtrate is inserted in vacuum concentration pan, setting vacuum 97kPa, temperature 55 DEG C ~ 70 DEG C, be condensed into concentrated solution, concentrated solution is 25% of major ingredient component;

3. spraying dry: spray dryer setting inlet temperature is 125 DEG C, leaving air temp is 85 DEG C, pressure is 80Moa, wind speed is 0.85m3/min, carries out hot-air spray drying and obtains mixed powder;

4. be mixed with: add adjuvant component in a kettle., adjustment kettle temperature 60 C ~ 65 DEG C, stir, more slowly add mixed powder, uniform stirring 30min, both obtain paste finished product.

Embodiment 3

(1) component:

1. major ingredient component:: Cortex Pseudolaricis 50g, Radix Sophorae Flavescentis 40g, Fructus Cnidii 40g, Fructus Kochiae 36g, Cortex Dictamni 28g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 40g, Spina Gleditsiae 36g, Herba Typhonii gigantei 40g, Ilex rotunda Thunb. 60g;

2. adjuvant component: white vaseline 800g;

(2) technique preparation process:

1. hot dipping is carried: by the remove impurity of major ingredient component, cleaning, oven dry, pulverizing, inserts in jacketed pan and adds 6 times of water gagings, and temperature 100 DEG C ~ 110 DEG C lixiviate 1h, get lixiviating solution and deposit; Add 6 times amount flooding 1h again, merge twice lixiviating solution, use 100 mesh screen;

2. concentrate: filtrate is inserted in vacuum concentration pan, setting vacuum 97kPa, temperature 55 DEG C ~ 70 DEG C, be condensed into concentrated solution, concentrated solution is 25% of major ingredient component;

3. spraying dry: spray dryer setting inlet temperature is 125 DEG C, leaving air temp is 85 DEG C, pressure is 80Moa, wind speed is 0.85m3/min, carries out hot-air spray drying and obtains mixed powder;

4. be mixed with: add adjuvant component in a kettle., adjustment kettle temperature 60 C ~ 65 DEG C, stir, more slowly add mixed powder, uniform stirring 30min, both obtain paste finished product.

The above; embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under the prerequisite of spirit not departing from the technology of the present invention; the various distortion that this area engineers and technicians make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determine.

Claims (2)

1. Cortex Pseudolaricis dermatitis plaster and preparation method thereof, is characterized in that: major ingredient component: Cortex Pseudolaricis 40g ~ 50g, Radix Sophorae Flavescentis 30g ~ 40g, Fructus Cnidii 35g ~ 40g, Fructus Kochiae 30g ~ 36g, Cortex Dictamni 25g ~ 28g, Radix Euphorbiae Fischerianae (Radix Euphorbiae Ebracteolatae) 30g ~ 40g, Spina Gleditsiae 33g ~ 36g, Herba Typhonii gigantei 30g ~ 40g, Ilex rotunda Thunb. 50g ~ 60g; Adjuvant component: white vaseline 500g ~ 800g.

2. a kind of Cortex Pseudolaricis dermatitis plaster according to claim 1 and preparation method thereof, is characterized in that: technique preparation process is as follows:

(1) hot dipping is carried: by the remove impurity of major ingredient component, cleaning, oven dry, pulverizing, inserts in jacketed pan and adds 6 times of water gagings, and temperature 100 DEG C ~ 110 DEG C lixiviate 1h, get lixiviating solution and deposit; Add 6 times amount flooding 1h again, merge twice lixiviating solution, use 100 mesh screen;

(2) concentrate: filtrate is inserted in vacuum concentration pan, setting vacuum 97kPa, temperature 55 DEG C ~ 70 DEG C, be condensed into concentrated solution, concentrated solution is 25% of major ingredient component;

(3) spraying dry: spray dryer setting inlet temperature is 125 DEG C, leaving air temp is 85 DEG C, pressure is 80Moa, wind speed is 0.85m3/min, carries out hot-air spray drying and obtains mixed powder;

(4) be mixed with: add adjuvant component in a kettle., adjustment kettle temperature 60 C ~ 65 DEG C, stir, more slowly add mixed powder, uniform stirring 30min, both obtain paste finished product.