CN104940361B - A kind of Whelk-eliminating paste and preparation method thereof - Google Patents
A kind of Whelk-eliminating paste and preparation method thereof Download PDFInfo
- Publication number
- CN104940361B CN104940361B CN201510300586.8A CN201510300586A CN104940361B CN 104940361 B CN104940361 B CN 104940361B CN 201510300586 A CN201510300586 A CN 201510300586A CN 104940361 B CN104940361 B CN 104940361B
- Authority
- CN
- China
- Prior art keywords
- parts
- whelk
- water
- chinese medicine
- active ingredient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a kind of Whelk-eliminating paste and preparation method thereof, which is made of active ingredient and auxiliary material, and the active ingredient is prepared by the traditional Chinese medicinal material raw materials of following parts by weight through water extract-alcohol precipitation：20 32 parts of dahurian loosestrife herb with root, 20 32 parts of Lysimachia foenum-graecum, 12 18 parts of turnip seed, 15 25 parts of fingered citron, 10 18 parts of Fructus Liquidambaris.The Chinese medicine Whelk-eliminating paste of the present invention has effects that significantly to inhibit propionibacterium acnes, and the generation of Triclosan is 0.2 0.3mg/mL to the minimal inhibitory concentration of propionibacterium acnes, hence it is evident that better than the minimum inhibitory concentration of clindamycin emulsifiable paste.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, treat dermopathic external preparation in particular to a kind of, especially
It is related to a kind of Whelk-eliminating paste for treating acne and preparation method thereof.
Background technology
Acne is to betide the sebaceous glands chronic disease of puberty and manhood, the positions such as main appearance face, thoracic dorsal
The chronic inflammation of hair follicle, sebaceous glands is mainly in Juvenile development period and middle aged men and women, papule, warts, tubercle, tumour is presented
With a variety of damages such as scar, part population can lose scar.Modern medicine thinks that this disease is mainly internal hyperleydigism
Caused by local infection Propiobacterium, though it is effective with estrogen orally taken for curing, because adverse reaction is too big, cancer is easy to cause,
So clinic is rarely employed.With the continuous improvement of living standards, people increasingly pay attention to the feature of environmental protection of daily chemical product, security
And natural sex.Chinese medicine daily chemical product is the product made of effective component extracting from Chinese herbal medicine and natural plants, it is followed certainly
Right environment and the sustainable development requirement of the mankind, meet pursuit of the people to high-quality life.
The content of the invention
It is an object of the invention to provide a kind of Whelk-eliminating pastes for treating acne and preparation method thereof.
In order to achieve the object of the present invention, inventor is final to obtain by being furtherd investigate and being improved to folk remedy
Following technical solution：
A kind of Whelk-eliminating paste for treating acne, the Whelk-eliminating paste are made of active ingredient and auxiliary material, wherein the active ingredient
It is prepared by the traditional Chinese medicinal material raw materials of following parts by weight through water extract-alcohol precipitation：20-32 parts of dahurian loosestrife herb with root, 20-32 parts of Lysimachia foenum-graecum, turnip seed
12-18 parts, 15-25 parts of fingered citron, 10-18 parts of Fructus Liquidambaris.
Preferably, the Whelk-eliminating paste of acne is treated as described above, wherein the active ingredient is by following parts by weight
Medicinal raw material is prepared through water extract-alcohol precipitation：25-28 parts of dahurian loosestrife herb with root, 25-28 parts of Lysimachia foenum-graecum, 14-16 parts of turnip seed, fingered citron 19-
21 parts, 13-15 parts of Fructus Liquidambaris.
In the prepreerence embodiment of the present invention, the Whelk-eliminating paste as described above for treating acne, wherein described
Active ingredient is prepared by the traditional Chinese medicinal material raw materials of following parts by weight through water extract-alcohol precipitation：27 parts of dahurian loosestrife herb with root, 27 parts of Lysimachia foenum-graecum, turnip
15 parts of son, 20 parts of fingered citron, 14 parts of Fructus Liquidambaris.
The preparation method of the Whelk-eliminating paste of the present invention is as follows：
(1) take 20-32 parts of traditional Chinese medicinal material raw materials dahurian loosestrife herb with root, 20-32 parts of Lysimachia foenum-graecum, 12-18 parts of turnip seed, 15-25 parts of fingered citron,
10-18 parts of Fructus Liquidambaris adds water to cook extraction 1-4h, and after decocting liquid is concentrated plus ethyl alcohol makes volume alcohol content reach 70-78% (preferably
74-76%), when 0 DEG C of refrigeration 12-48 is small, filtration, filtrate recycling ethanol simultaneously concentrates, dry, obtains Chinese medicine dried cream powder；
(2) stearic acid, glycerin monostearate, atoleine and the albolene of recipe quantity are weighed, mixing is as oil phase；
(3) glycerine, Tween 80, potassium sorbate and the portions of de-ionized water of recipe quantity are weighed, mixing is as water phase；
(4) oil phase is mutually separately heated to 75-80 DEG C with water is completely dissolved matrix, and water is mutually slowly poured into thread shape
In oil phase, the Chinese medicine dried cream powder dissolved with balance deionized water is added, in the emulsified 15- of rotating speed 150-300r/min
60min obtains Chinese medicine Whelk-eliminating paste.
It should be noted that traditional Chinese medicinal material raw materials source of the present invention is as follows：Dahurian loosestrife herb with root selects Primulaceae coptis root
Flower Lysimachia vulgaris L.var.davurica (Ledeb.) R.Knuth drying whole herb with root.Lysimachia foenum-graecum selects report
The dry aerial parts of spring flower section Lysimachia sikokiana platymiscium Lysimachia foenum-graecum Lysimachia foenum-graecum Hance.Turnip seed selects
With the dry seed of crucifer turnip Brassica rapa L..Fingered citron selects Rutaceae citrus plant fingered citron
The dry mature fruit of Citrus medica L.var.sarcodactylis Swingle.Fructus Liquidambaris selects Hamamelidaceae to plant
The drying and ripening infructescence of object Chinese sweet gum Liquidambar formosana Hance.
The present invention Chinese medicine Whelk-eliminating paste have effects that significantly to inhibit propionibacterium acnes, the generation of Triclosan,
Minimal inhibitory concentration to propionibacterium acnes is 0.2-0.3mg/mL, hence it is evident that minimum antibacterial better than clindamycin emulsifiable paste
Concentration.
Description of the drawings
Fig. 1：Chinese medicine Whelk-eliminating paste and clindamycin emulsifiable paste inhibit the comparing result of propionibacterium acnes.
Specific embodiment
It is specific embodiments of the present invention below, technical scheme is done and is further described, but it is of the invention
Protection domain be not limited to these embodiments.It is every to be included in this hair without departing substantially from the change of present inventive concept or equivalent substitute
Within bright protection domain.
Embodiment 1：The preparation of Chinese medicine dried cream powder
Prescription：Dahurian loosestrife herb with root 270g, Lysimachia foenum-graecum 270g, turnip seed 150g, fingered citron 200g, Fructus Liquidambaris 140g.
Preparation method：The above-mentioned traditional Chinese medicinal material raw materials of recipe quantity are taken, clean impurity elimination, water is added to cover powder 2cm, impregnate 1-
1.2h, pulls medicinal material out and puts and add water to cook secondary in multi-function extraction tank, adds up the water of 12 times of medicinal material amount for the first time, decocts 2h, take
Decocting liquid, filtration, second of the water for adding up 8 times of amounts of medicinal material decoct 1.5h, take decocting liquid merging twice, and filtration is concentrated into 65 DEG C of phases
To the concentrate that density is 1.05；Add ethanol in proper amount make volume alcohol content up to 75%, 0 DEG C refrigeration 24 it is small when, filtration, filtrate recycling
Ethyl alcohol is simultaneously concentrated into the medicinal extract that relative density is 1.20, and freeze-drying obtains Chinese medicine dried cream powder.
Embodiment 2：The preparation of Chinese medicine Whelk-eliminating paste
Prescription：Chinese medicine dried cream powder 3.0g, dimethyl sulfoxide (DMSO) 7.0g, stearic acid 1.2g, Tween 80 9.0g, glycerol monostearate
Ester 18.0g, atoleine 18.0g, albolene 12.0g, glycerine 20.0g, potassium sorbate 0.3g, deionized water add to
200.0g。
Preparation method：Respectively oil phase (stearic acid, glycerin monostearate, atoleine, Bai Fanshi are weighed by recipe quantity
Woods) and water phase (glycerine, Tween 80, potassium sorbate, the deionized water of 50% amount), mixing respectively is placed in beaker, by oil phase
80 DEG C are mutually separately heated to water is completely dissolved matrix, and water mutually with thread shape is slowly poured into oil phase, adds prior use
The Chinese medicine dried cream powder (being prepared according to the formulation and technology of embodiment 1) that balance deionized water has dissolved, it is emulsified in 200r/min
After 30min, beaker is taken out, emulsifiable paste shape is at the uniform velocity stirred into glass bar, cooled to room temperature is up to Chinese medicine Whelk-eliminating paste.
Embodiment 3：The study on the stability of Chinese medicine Whelk-eliminating paste
3 batches of Chinese medicine Whelk-eliminating pastes prepared according to 2 formulation and technology of embodiment are randomly selected, are centrifuged respectively at 6000r/min
20min places 6h at 55 DEG C, is placed at -20 DEG C for 24 hours, carries out study on the stability, as a result 3 batches of finished product emulsifiable paste appearances are without bright
Aobvious variation.
Embodiment 4：The antibacterial activity testing research of Chinese medicine Whelk-eliminating paste
After tested, the Chinese medicine Whelk-eliminating paste of above-mentioned preparation has effects that significantly to inhibit propionibacterium acnes, can inhibit Cuo
The generation of sore, the minimal inhibitory concentration to propionibacterium acnes are 0.2-0.3mg/mL, hence it is evident that better than clindamycin emulsifiable paste
Minimum inhibitory concentration.Specifically as shown in Figure 1.
Embodiment 5：The clinical application research of Chinese medicine Whelk-eliminating paste
Face acnes patient 48, male 17, women 31；Age is 14 years old minimum, 40 years old maximum；The most short 20d of the course of disease,
It is most 8 years long.It is randomly divided into treatment group and control group.Treatment group 24, male 9, women 15；Age is 16 years old minimum, maximum
40 years old；The most short 20d of the course of disease, most 8 years long, the Chinese medicine Whelk-eliminating paste prepared using 2 formulation and technology of embodiment is treated.Control group 24,
Male 8, women 16；Age is 14 years old minimum, 39 years old maximum；The course of disease most short 30d, it is most 8 years long, use 0.8% clindamycin
Cream for treating.Two groups of cases are statistically analyzed no significant difference, P in gender, age, the course of disease etc.>0.05, have comparable
Property.
Application method：Face first washes with water totally, takes Whelk-eliminating paste appropriate, is uniformly applied to affected part, 2-3 times daily, even
It is continuous to use 2 weeks or more.
Criterion of therapeutical effect：It was treated through 2 weeks, skin lesion disappears more than 95% as recovery from illness；Skin lesion regression more than 60% is effective；Skin lesion
Regression more than 30% is effective；Skin lesion regression less than 30% is invalid.Total effective rate=(recovery from illness number of cases+effective number of cases+effective example
Number)/total number of cases × 100%.
Treatment results：It fully recovers 12 in treatment group 24, effective 9, effective 2, invalid 1, total effective rate 95.8%.
It fully recovers 8 in control group 24, effective 6, effective 5, invalid 5, total effective rate 79.2%.Obviously, Chinese medicine of the invention
Whelk-eliminating paste treatment acne effect is better than clindamycin emulsifiable paste.
Claims (4)
1. a kind of acne Whelk-eliminating paste for the treatment of is preparing the application in inhibiting propionibacterium acnes drug, the Whelk-eliminating paste is by active ingredient
It is made with auxiliary material, it is characterised in that：The active ingredient by following parts by weight traditional Chinese medicinal material raw materials through water extract-alcohol precipitation prepare and
：20-32 parts of dahurian loosestrife herb with root, 20-32 parts of Lysimachia foenum-graecum, 12-18 parts of turnip seed, 15-25 parts of fingered citron, 10-18 parts of Fructus Liquidambaris；
The preparation method of the Whelk-eliminating paste includes the following steps：
(1) 20-32 parts of traditional Chinese medicinal material raw materials dahurian loosestrife herb with root, 20-32 parts of Lysimachia foenum-graecum, 12-18 parts of turnip seed, 15-25 parts of fingered citron, Lu Lu are taken
It is 10-18 parts logical, extraction 1-4h is added water to cook, after decocting liquid is concentrated plus ethyl alcohol makes volume alcohol content up to 70-78%, 0 DEG C of refrigeration 12-
48 it is small when, filtration, filtrate recycling ethanol simultaneously concentrates, dry, obtains Chinese medicine dried cream powder；
(2) stearic acid, glycerin monostearate, atoleine and the albolene of recipe quantity are weighed, mixing is as oil phase；
(3) glycerine, Tween 80, potassium sorbate and the portions of de-ionized water of recipe quantity are weighed, mixing is as water phase；
(4) oil phase is mutually separately heated to 75-80 DEG C with water is completely dissolved matrix, and water is slowly mutually poured into oil phase with thread shape
In, the Chinese medicine dried cream powder dissolved with balance deionized water is added, in the emulsified 15-60min of rotating speed 150-300r/min, is obtained
Chinese medicine Whelk-eliminating paste.
2. application according to claim 1, it is characterised in that：The active ingredient is former by the Chinese medicine of following parts by weight
Material is prepared through water extract-alcohol precipitation：25-28 parts of dahurian loosestrife herb with root, 25-28 parts of Lysimachia foenum-graecum, 14-16 parts of turnip seed, 19-21 parts of fingered citron, road
Road leads to 13-15 parts.
3. application according to claim 2, it is characterised in that：The active ingredient is former by the Chinese medicine of following parts by weight
Material is prepared through water extract-alcohol precipitation：27 parts of dahurian loosestrife herb with root, 27 parts of Lysimachia foenum-graecum, 15 parts of turnip seed, 20 parts of fingered citron, 14 parts of Fructus Liquidambaris.
4. application according to claim 1, which is characterized in that after decocting liquid is concentrated in step (1) plus ethyl alcohol contains volume
Alcohol amount reaches 74-76%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510300586.8A CN104940361B (en) | 2015-06-04 | 2015-06-04 | A kind of Whelk-eliminating paste and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510300586.8A CN104940361B (en) | 2015-06-04 | 2015-06-04 | A kind of Whelk-eliminating paste and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104940361A CN104940361A (en) | 2015-09-30 |
| CN104940361B true CN104940361B (en) | 2018-05-29 |
Family
ID=54155791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510300586.8A Active CN104940361B (en) | 2015-06-04 | 2015-06-04 | A kind of Whelk-eliminating paste and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104940361B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113520954A (en) * | 2021-08-24 | 2021-10-22 | 苏州健雄职业技术学院 | Traditional Chinese medicine acne removing cream and production process thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302712A (en) * | 2011-09-07 | 2012-01-04 | 王琴 | Fragrant acne-removing liquid |
| CN102397405A (en) * | 2011-11-28 | 2012-04-04 | 西北农林科技大学 | Compound bergamot oil nano-emulsion composition and preparation method thereof |
| CN103463499A (en) * | 2013-09-27 | 2013-12-25 | 刘芳 | New ointment for treating acne |
-
2015
- 2015-06-04 CN CN201510300586.8A patent/CN104940361B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302712A (en) * | 2011-09-07 | 2012-01-04 | 王琴 | Fragrant acne-removing liquid |
| CN102397405A (en) * | 2011-11-28 | 2012-04-04 | 西北农林科技大学 | Compound bergamot oil nano-emulsion composition and preparation method thereof |
| CN103463499A (en) * | 2013-09-27 | 2013-12-25 | 刘芳 | New ointment for treating acne |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104940361A (en) | 2015-09-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105395440B (en) | Peach gum mask and preparation method and application thereof | |
| CN102861274B (en) | External use traditional Chinese medicine for treating eczema | |
| CN104161704B (en) | The pure natural shampoo that herbal raw material makes | |
| CN108498390B (en) | Tibetan herbal extract for treating acne and preparation method and application thereof | |
| CN106176784B (en) | It is a kind of for the pharmaceutical composition of dermatitis, application, preparation and preparation method thereof | |
| CN103100075B (en) | Medicament for treating eczema | |
| CN108245653A (en) | A kind of Traditional Chinese medicine alopecia-preventing pilatory | |
| CN105816507A (en) | Bletilla striata callus skin care preparation and preparation method thereof | |
| WO2016180070A1 (en) | Topical drug for treating breast cancer and preparation method thereof | |
| CN104940361B (en) | A kind of Whelk-eliminating paste and preparation method thereof | |
| CN104958543A (en) | Traditional Chinese medicinal acne removing and skin cleansing lotion, and preparation method thereof | |
| CN102188690B (en) | Hair growth lotion and preparation method thereof | |
| CN100358567C (en) | compound of Chinese traditional medicine and Western medicine in use for growing hair and blackening hair | |
| DK201670336A1 (en) | A Barbados aloe scar eliminating ointment | |
| CN106692458A (en) | Medicine composition for treating acnes as well as preparation method and application thereof | |
| CN103989598A (en) | Whitening freckle-removing cosmetic containing integripetal rhodiola herb extract | |
| CN103142958A (en) | Medicament for treating perniosis | |
| CN107773497A (en) | A kind of hair nutrition liquid and its production technology | |
| CN103356935A (en) | Traditional Chinese medicine for treating dermatophytosis, and preparation method thereof | |
| CN105012503A (en) | Ointment for treating scalding and preparing method thereof | |
| CN107050126A (en) | Chinese drugs agentia for treating acne | |
| CN103656593A (en) | Externally-applied medicine paste for treating burns and preparation method of paste | |
| CN105617139A (en) | Traditional Chinese medicine composition with skin-whitening effect as well as preparation method therefor and application thereof | |
| CN106619289A (en) | Anti-allergen acne-removing and moisturizing composition containing frangipani alcohol extract and preparation method | |
| CN104983812A (en) | Composite for treating ultraviolet allergy and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |