CN104940361A - Anti-acne paste and preparation method thereof - Google Patents
Anti-acne paste and preparation method thereof Download PDFInfo
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- CN104940361A CN104940361A CN201510300586.8A CN201510300586A CN104940361A CN 104940361 A CN104940361 A CN 104940361A CN 201510300586 A CN201510300586 A CN 201510300586A CN 104940361 A CN104940361 A CN 104940361A
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Abstract
The invention discloses an anti-acne paste and a preparation method thereof. The anti-acne paste is composed of active components and auxiliary materials. The active components are prepared through the water extraction and alcohol precipitation process of the following traditional Chinese medicine raw materials in weight part: 20-32 parts of nelumbo lutea, 20-32 parts of lysimachia foenum-graecum, 12-18 parts of brassica rapa, 15-25 parts of fructus citrus sarcodactylis and 10-18 parts of fructus liquidambaris. According to the technical scheme of the invention, the anti-acne paste can obviously inhibit the activity of propionibacterium acnes and prevent the formation of acnes. The minimum inhibitory mass concentration of the anti-acne paste for propionibacterium acnes is 0.2-0.3 mg/Ml and is significantly superior to that of the clindamycin cream.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, treat dermopathic external preparation in particular to one, particularly relate to Whelk-eliminating paste of a kind of Acne treatment and preparation method thereof.
Background technology
Acne is the sebaceous gland chronic disease betiding adolescence and manhood, the hair follicle at position, the chronic inflammatory diseases of sebaceous gland such as main appearance face, thoracic dorsal, be mainly in Juvenile development period and middle aged men and women, present the multiple infringements such as pimple, pustule, tuberosity, cyst and cicatrix, part population can lose cicatrix.Modern medicine thinks this disease mainly in body caused by hyperleydigism and local infection Propiobacterium, though effective with estrogen orally taken for curing, because untoward reaction is too large, easily causes cancer, so clinical little use.Along with improving constantly of living standard, people more and more note the feature of environmental protection of cosmetics of everyday use, safety and natural sex.Chinese medicine cosmetics of everyday use is the product that effective component extracting is made from Chinese herbal medicine and natural plants, and it follows the sustainable development requirement of natural environment and the mankind, meets the pursuit of people to high-quality life.
Summary of the invention
The object of the present invention is to provide Whelk-eliminating paste of a kind of Acne treatment and preparation method thereof.
In order to realize object of the present invention, inventor, by furtheing investigate folk remedy and improving, finally obtains following technical scheme:
A kind of Whelk-eliminating paste of Acne treatment, this Whelk-eliminating paste is made up of active component and adjuvant, and wherein said active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba lysimachiae davuricae 20-32 part, Herba Lysimachiae foenum-graeci 20-32 part, Semen Brassicae Rapae 12-18 part, Fructus Citri Sarcodactylis 15-25 part, Fructus Liquidambaris 10-18 part.
Preferably, the Whelk-eliminating paste of Acne treatment as above, wherein said active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba lysimachiae davuricae 25-28 part, Herba Lysimachiae foenum-graeci 25-28 part, Semen Brassicae Rapae 14-16 part, Fructus Citri Sarcodactylis 19-21 part, Fructus Liquidambaris 13-15 part.
In a prepreerence embodiment of the present invention, the Whelk-eliminating paste of Acne treatment as above, wherein said active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba lysimachiae davuricae 27 parts, Herba Lysimachiae foenum-graeci 27 parts, Semen Brassicae Rapae 15 parts, Fructus Citri Sarcodactylis 20 parts, Fructus Liquidambaris 14 parts.
The preparation method of Whelk-eliminating paste of the present invention is as follows:
(1) traditional Chinese medicinal material raw materials Herba lysimachiae davuricae 20-32 part, Herba Lysimachiae foenum-graeci 20-32 part, Semen Brassicae Rapae 12-18 part, Fructus Citri Sarcodactylis 15-25 part, Fructus Liquidambaris 10-18 part is got, decoct with water and extract 1-4h, decocting liquid adds ethanol after concentrated makes volume alcohol content reach 70-78% (preferred 74-76%), 0 DEG C of cold preservation 12-48 hour, filter, filtrate recycling ethanol is also concentrated, dry, obtains Chinese medicine dried cream powder;
(2) take the stearic acid of recipe quantity, glyceryl monostearate, liquid paraffin and white vaseline, mix as oil phase;
(3) take the glycerol of recipe quantity, Tween 80, potassium sorbate and portions of de-ionized water, mix as aqueous phase;
(4) oil phase and aqueous phase being heated to 75-80 DEG C respectively makes substrate dissolve completely, aqueous phase is slowly poured in oil phase with thread shape, add the Chinese medicine dried cream powder dissolved with balance deionized water again, at the emulsified 15-60min of rotating speed 150-300r/min, obtain Chinese medicine Whelk-eliminating paste.
It should be noted that, traditional Chinese medicinal material raw materials source of the present invention is as follows: Herba lysimachiae davuricae selects the dry whole herb with root of Primulaceae Herba lysimachiae davuricae Lysimachia vulgaris L.var.davurica (Ledeb.) R.Knuth.Herba Lysimachiae foenum-graeci selects the dry aerial parts of Primulaceae Lysimachia plant Herba Lysimachiae foenum-graeci Lysimachia foenum-graecum Hance.Semen Brassicae Rapae selects the dry seed of crucifer Radix Brassicae rapae Brassica rapa L..Fructus Citri Sarcodactylis selects the dry mature fruit of Rutaceae citrus plant Fructus Citri Sarcodactylis Citrus medica L.var.sarcodactylis Swingle.Fructus Liquidambaris selects the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum Liquidambar formosana Hance.
Chinese medicine Whelk-eliminating paste of the present invention has significant effect suppressing propionibacterium acnes, and the generation of Triclosan, is 0.2-0.3mg/mL to the minimal inhibitory concentration of propionibacterium acnes, is obviously better than the minimum inhibitory concentration of clindamycin emulsifiable paste.
Accompanying drawing explanation
Fig. 1: Chinese medicine Whelk-eliminating paste and clindamycin emulsifiable paste suppress the comparing result of propionibacterium acnes.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1: the preparation of Chinese medicine dried cream powder
Prescription: Herba lysimachiae davuricae 270g, Herba Lysimachiae foenum-graeci 270g, Semen Brassicae Rapae 150g, Fructus Citri Sarcodactylis 200g, Fructus Liquidambaris 140g.
Preparation method: the above-mentioned traditional Chinese medicinal material raw materials getting recipe quantity, cleans roguing, adds water and cover powder 2cm, soak 1-1.2h, pull medical material out and put during multi-functional extractions is filled with and decoct with water secondary, first time totalling medical material 12 times amount water, decoct 2h, get decocting liquid, filter, second time adds up the water of medical material 8 times amount, decoct 1.5h, get twice decocting liquid to merge, filter, when being concentrated into 65 DEG C, relative density is the concentrated solution of 1.05; Adding ethanol in proper amount makes volume alcohol content reach 75%, 0 DEG C of cold preservation 24 hours, and filter, filtrate recycling ethanol is also concentrated into the extractum that relative density is 1.20, lyophilization, obtains Chinese medicine dried cream powder.
Embodiment 2: the preparation of Chinese medicine Whelk-eliminating paste
Prescription: Chinese medicine dried cream powder 3.0g, dimethyl sulfoxide 7.0g, stearic acid 1.2g, Tween 80 9.0g, glyceryl monostearate 18.0g, liquid paraffin 18.0g, white vaseline 12.0g, glycerol 20.0g, potassium sorbate 0.3g, deionized water adds to 200.0g.
Preparation method: press recipe quantity respectively and weigh oil phase (stearic acid, glyceryl monostearate, liquid paraffin, white vaseline) and aqueous phase (glycerol, Tween 80, potassium sorbate, the deionized water of 50% amount), mixing is placed in beaker respectively, oil phase and aqueous phase are heated to 80 DEG C respectively makes substrate dissolve completely, aqueous phase is slowly poured in oil phase with thread shape, add the Chinese medicine dried cream powder (preparing according to the formulation and technology of embodiment 1) that prior balance deionized water has dissolved again, after the emulsified 30min of 200r/min, take out beaker, emulsifiable paste shape is at the uniform velocity stirred into Glass rod, naturally cool to room temperature and namely obtain Chinese medicine Whelk-eliminating paste.
Embodiment 3: the study on the stability of Chinese medicine Whelk-eliminating paste
Randomly draw 3 batches of Chinese medicine Whelk-eliminating pastes prepared according to embodiment 2 formulation and technology, respectively at the centrifugal 20min of 6000r/min, place 6h, place 24h at-20 DEG C, carry out study on the stability at 55 DEG C, 3 batches of finished product emulsifiable paste outward appearances are without significant change as a result.
Embodiment 4: the antibacterial activity testing research of Chinese medicine Whelk-eliminating paste
After tested, the Chinese medicine Whelk-eliminating paste of above-mentioned preparation has significant effect suppressing propionibacterium acnes, the generation of Triclosan, is 0.2-0.3mg/mL to the minimal inhibitory concentration of propionibacterium acnes, is obviously better than the minimum inhibitory concentration of clindamycin emulsifiable paste.Specifically as shown in Figure 1.
Embodiment 5: the clinical application research of Chinese medicine Whelk-eliminating paste
Facial acne patient 48 example, male 17 example, women 31 example; Minimum 14 years old of age, maximum 40 years old; The shortest 20d of the course of disease, the longest 8 years.Be divided into treatment group and matched group at random.Treatment group 24 example, male 9 example, women 15 example; Minimum 16 years old of age, maximum 40 years old; The shortest 20d of the course of disease, the longest 8 years, the Chinese medicine Whelk-eliminating paste treatment using embodiment 2 formulation and technology to prepare.Matched group 24 example, male 8 example, women 16 example; Minimum 14 years old of age, maximum 39 years old; The shortest 30d of the course of disease, the longest 8 years, use 0.8% clindamycin cream for treating.Two groups of cases in sex, age, the course of disease etc. through statistical procedures without significant difference, P>0.05, has comparability.
Using method: face first cleans up with water, gets Whelk-eliminating paste appropriate, and uniform application, in affected part, every day 2-3 time, uses more than 2 weeks continuously.
Criterion of therapeutical effect: through treatment in 2 weeks, skin lesion disappears more than 95% for recovery from illness; Skin lesion disappears more than 60% for effective; It more than 30% is effective that skin lesion disappears; Skin lesion disappears less than 30% for invalid.Total effective rate=(recovery from illness number of cases+effective number of cases+effectively number of cases)/total number of cases × 100%.
Therapeutic outcome: 12 examples of fully recovering in treatment group 24 example, effective 9 examples, effective 2 examples, invalid 1 example, total effective rate 95.8%.Recovery from illness 8 example in matched group 24 example, effective 6 examples, effective 5 examples, invalid 5 examples, total effective rate 79.2%.Obviously, Chinese medicine Whelk-eliminating paste Acne treatment effect of the present invention is better than clindamycin emulsifiable paste.
Claims (5)
1. an Acne treatment Whelk-eliminating paste, this Whelk-eliminating paste is made up of active component and adjuvant, it is characterized in that: described active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba lysimachiae davuricae 20-32 part, Herba Lysimachiae foenum-graeci 20-32 part, Semen Brassicae Rapae 12-18 part, Fructus Citri Sarcodactylis 15-25 part, Fructus Liquidambaris 10-18 part.
2. the Whelk-eliminating paste of Acne treatment according to claim 1, is characterized in that: described active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba lysimachiae davuricae 25-28 part, Herba Lysimachiae foenum-graeci 25-28 part, Semen Brassicae Rapae 14-16 part, Fructus Citri Sarcodactylis 19-21 part, Fructus Liquidambaris 13-15 part.
3. the Whelk-eliminating paste of Acne treatment according to claim 2, is characterized in that: described active component is prepared through water extract-alcohol precipitation by the traditional Chinese medicinal material raw materials of following weight portion and obtains: Herba lysimachiae davuricae 27 parts, Herba Lysimachiae foenum-graeci 27 parts, Semen Brassicae Rapae 15 parts, Fructus Citri Sarcodactylis 20 parts, Fructus Liquidambaris 14 parts.
4. a preparation method for Whelk-eliminating paste, is characterized in that, the method comprises the steps:
(1) traditional Chinese medicinal material raw materials Herba lysimachiae davuricae 20-32 part, Herba Lysimachiae foenum-graeci 20-32 part, Semen Brassicae Rapae 12-18 part, Fructus Citri Sarcodactylis 15-25 part, Fructus Liquidambaris 10-18 part is got, decoct with water and extract 1-4h, decocting liquid adds ethanol after concentrated makes volume alcohol content reach 70-78%, 0 DEG C of cold preservation 12-48 hour, filter, filtrate recycling ethanol is also concentrated, dry, obtains Chinese medicine dried cream powder;
(2) take the stearic acid of recipe quantity, glyceryl monostearate, liquid paraffin and white vaseline, mix as oil phase;
(3) take the glycerol of recipe quantity, Tween 80, potassium sorbate and portions of de-ionized water, mix as aqueous phase;
(4) oil phase and aqueous phase being heated to 75-80 DEG C respectively makes substrate dissolve completely, aqueous phase is slowly poured in oil phase with thread shape, add the Chinese medicine dried cream powder dissolved with balance deionized water again, at the emulsified 15-60min of rotating speed 150-300r/min, obtain Chinese medicine Whelk-eliminating paste.
5. the preparation method of Whelk-eliminating paste according to claim 4, is characterized in that, the middle decocting liquid of step (1) adds ethanol after concentrated makes volume alcohol content reach 74-76%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113520954A (en) * | 2021-08-24 | 2021-10-22 | 苏州健雄职业技术学院 | Traditional Chinese medicine acne removing cream and production process thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302712A (en) * | 2011-09-07 | 2012-01-04 | 王琴 | Fragrant acne-removing liquid |
| CN102397405A (en) * | 2011-11-28 | 2012-04-04 | 西北农林科技大学 | Compound bergamot oil nano-emulsion composition and preparation method thereof |
| CN103463499A (en) * | 2013-09-27 | 2013-12-25 | 刘芳 | New ointment for treating acne |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302712A (en) * | 2011-09-07 | 2012-01-04 | 王琴 | Fragrant acne-removing liquid |
| CN102397405A (en) * | 2011-11-28 | 2012-04-04 | 西北农林科技大学 | Compound bergamot oil nano-emulsion composition and preparation method thereof |
| CN103463499A (en) * | 2013-09-27 | 2013-12-25 | 刘芳 | New ointment for treating acne |
Non-Patent Citations (1)
| Title |
|---|
| 周宝宽著: "《很灵很灵的中药方，面部皮肤病一扫光》", 30 June 2014 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113520954A (en) * | 2021-08-24 | 2021-10-22 | 苏州健雄职业技术学院 | Traditional Chinese medicine acne removing cream and production process thereof |
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