CN106309275A - Skin-moisturizing acne-removing lotion and preparation method thereof - Google Patents
Skin-moisturizing acne-removing lotion and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention relates to a skin-moisturizing acne-removing lotion and a preparation method thereof and belongs to the technical field of cosmetics. The skin-moisturizing acne-removing lotion is prepared from, by weight, ginseng, salvia miltiorrhiza, scutellaria baicalensis, a marigold extract, hyaluronic acid, bletilla striata, a green tea extract, lemon essential oil, 1,2-decanediol, aloe vera gel, lavender essential oil, chamomile essential oil, vitamin E, carbomer, glycerin, essence, an emulsifier and deionized water. The skin-moisturizing acne-removing lotion adopts natural medicinal materials as main ingredients, and the prepared health-care lotion has the skin-moisturizing acne-removing effects during external use.
Description
Technical field
The present invention relates to a kind of skin moisture-keeping acne removing water and preparation method thereof, belong to cosmetic technical field.
Background technology
Acne, also known as " acne ", " comedo ", is what adolescence often occurred because sebum secretion is exaggerated, in chronic inflammatory
Dermatosis.Teenager men and women, just skin the richest nacreous period, but this age is vigorous due to hormone secretion, holds very much
The one that is easy to get is commonly called as crying the disease of " comedo ".This disease is medically called acne, and it is that a kind of pilosebaceous unit causes
Chronic inflammatory skin is sick, is mainly in teenager, and sickness rate is high.In teenager, sickness rate is 45-90%, prevalence before 13 years old
Female, higher than man, mostly is closo (papular type).After 13 years old, man is higher than female, and skin lesion is variation.Its age of onset is the most at present
Polarization, is no longer teenager patent, and overall women is more than male.Clinical manifestation, position is apt to occur in face, breast, greasiness district, back,
The most also other position is betided, symmetrical, often it is inviolable around face central authorities especially nose and eye socket.
Some acne topical drug uses the initial stage can become more serious, and even skin can be because of adaptive relation, it appears
The reddest but decortication.. because most medicine for external use can make skin the driest, can not smear during use too much, spread and see not
Go out the degree of the most coated medicine.General topical agent all lacks maintenance healing, the effect of anti-inflammatory allergy, so must be auxiliary
Composition is repaired in the moisturizing helping some bases.
Therefore it provides a kind of there is moisturizing, medicine for external use that acne-removal function has concurrently significant.
Summary of the invention
It is an object of the invention to: a kind of skin insulation liquid is provided, there is the effect of moisturizing, anti-acne.
Technical scheme:
A kind of skin moisture-keeping acne removing water, includes following component by weight: Radix Ginseng 3～4 parts, Radix Salviae Miltiorrhizae 10～15 parts, yellow
A kind of reed mentioned in ancient books 14～16 parts, Flos Inulae extract 0.1～0.3 part, hyaluronic acid 0.02～0.05 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4～7 parts, green tea extract
0.5～1 part, Fructus Citri Limoniae quintessence oil 0.05～0.1 part, Decane-1,2-diol 0.02～0.05 part, Aloe glue 0.5～1 part, Herba Lysimachiae foenum-graeci quintessence oil
0.03～0.05 part, chamomile essential oil 0.02～0.03 part, vitamin E 0.5～1.2 parts, carbomer 2～4 parts, glycerol 6～10
Part, essence 0.1～0.2 part, emulsifying agent 0.5～0.8 part, deionized water 50～80 parts.
Described emulsifying agent is ceteareth-20.
The preparation method of described skin moisture-keeping acne removing water, comprises the steps:
1st step, mixes the Pseudobulbus Bletillae (Rhizoma Bletillae), maltose according to weight ratio 1:3, adds Radix Ginseng weight 5～the water of 10 times, add medicated beer
Yeast, 30～36 DEG C of bottom fermentations 10 days, is warming up to 90～95 DEG C of sterilizings by fermentation liquid after terminating, then by fermentation liquid temperature rising reflux
Extracting, extracting solution is by after residue filter, and concentrating under reduced pressure is concentrated solution, then is spray-dried by concentrated solution, obtains the fermentation Pseudobulbus Bletillae (Rhizoma Bletillae) and carries
Take thing；
2nd step, after Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Scutellariae mixing, extracting in water, after extracting solution leaches residue, through concentrating under reduced pressure, it is dried
After, obtain medicinal substances extract；
3rd step, will fermentation bletilla striata extract, medicinal substances extract, Flos Inulae extract, hyaluronic acid, green tea extract, lemon extract
Oil, Decane-1,2-diol, Aloe glue, Herba Lysimachiae foenum-graeci quintessence oil, chamomile essential oil, vitamin E, carbomer, glycerol, essence, emulsifying agent, go
After ionized water mixing, heat up stirring, after letting cool, obtains skin moisture-keeping acne removing water.
In the 1st described step, extraction time is 2～4 hours.
In the 2nd described step, amount of water is 6 times of medical material weight, and extraction time is 1～3h, and Extracting temperature is 90～95
℃。
In the 3rd described step, the temperature of the stirring that heats up is 60～80 DEG C.
In the present invention, Radix Ginseng can slowly be absorbed by skin and without pessimal stimulation, energy skin expansion blood capillary, promote skin
Blood circulation, Radix Salviae Miltiorrhizae has obvious anti-acne, eliminates the effect of acne；Decane-1,2-diol is a kind of moisturizing with antibacterial characteristics
Agent, has broad spectrum antibiotic activity, can be applicable to acne of dispelling simultaneously；Hyaluronic acid can stimulate in ossein hypertrophy and locking skin
Moisture content, makes skin be full of elastic and gloss；The removable old dead cell of Fructus Citri Limoniae quintessence oil, the bright colour of skin, consolidation blood capillary, promote collagen
Albumen produces, and desalinates melanin, greasy skin of sending out is had effect of purification, can soften causes scar tissue；Improve oiliness skin, have clean
Skin, convergence, Bergamot Mint Extract, the effect of skin whitening；Radix Scutellariae extract has extraordinary SOD sample active function, also has
Having anti-acid, antibacterial, anti-light aging etc. acts on, and comedo is also had to preferable curative effect.
The present invention, by fermenting the Pseudobulbus Bletillae (Rhizoma Bletillae), can make macromolecular substances therein be broken down into small-molecule substance, more
Easily being absorbed by the skin, the clarity that also can make health-care water is more preferable.
Beneficial effect
The present invention uses crude drug as main component, and the health-care water the prepared outer used time has the effect of moisturizing, anti-acne.
Detailed description of the invention
Embodiment 1
A kind of skin moisture-keeping acne removing water, includes following component by weight: Radix Ginseng 3 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Scutellariae 14 parts,
Flos Inulae extract 0.1 part, hyaluronic acid 0.02 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4 parts, green tea extract 0.5 part, Fructus Citri Limoniae quintessence oil 0.05 part, 1,2-
Decanediol 0.02 part, Aloe glue 0.5 part, Herba Lysimachiae foenum-graeci quintessence oil 0.03 part, chamomile essential oil 0.02 part, vitamin E 0.5 part, card ripple
Nurse 2 parts, glycerol 6 parts, 0.1 part of essence, ceteareth-20 emulsifying agent 0.5 part, deionized water 50 parts.
Preparation method, comprises the steps:
1st step, mixes the Pseudobulbus Bletillae (Rhizoma Bletillae), maltose according to weight ratio 1:3, adds the water of Radix Ginseng weight 5 times, add medicated beer ferment
Mother, 30 DEG C of bottom fermentations 10 days, is warming up to fermentation liquid 90 DEG C of sterilizings, then is extracted 2 hours by fermentation liquid temperature rising reflux after terminating,
Extracting solution is by after residue filter, and concentrating under reduced pressure is concentrated solution, then is spray-dried by concentrated solution, obtains bletilla striata extract of fermenting；
2nd step, after Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Scutellariae mixing, extracting in water, amount of water is 6 times of medical material weight, and extraction time is 1h,
Extracting temperature is 90 DEG C, after extracting solution leaches residue, through concentrating under reduced pressure, after drying, obtains medicinal substances extract；
3rd step, will fermentation bletilla striata extract, medicinal substances extract, Flos Inulae extract, hyaluronic acid, green tea extract, lemon extract
Oil, Decane-1,2-diol, Aloe glue, Herba Lysimachiae foenum-graeci quintessence oil, chamomile essential oil, vitamin E, carbomer, glycerol, essence, emulsifying agent, go
After ionized water mixing, it is warming up to 60～80 DEG C of stirrings, after letting cool, obtains skin moisture-keeping acne removing water.
Embodiment 2
A kind of skin moisture-keeping acne removing water, includes following component by weight: Radix Ginseng 4 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Scutellariae 16 parts,
Flos Inulae extract 0.3 part, hyaluronic acid 0.05 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 7 parts, green tea extract 1 part, Fructus Citri Limoniae quintessence oil 0.1 part, 1,2-last of the ten Heavenly stems two
Alcohol 0.05 part, Aloe glue 1 part, Herba Lysimachiae foenum-graeci quintessence oil 0.05 part, chamomile essential oil 0.03 part, vitamin E 1.2 parts, carbomer 4 parts,
Glycerol 10 parts, 0.2 part of essence, ceteareth-20 emulsifying agent 0.8 part, deionized water 80 parts.
Preparation method, comprises the steps:
1st step, mixes the Pseudobulbus Bletillae (Rhizoma Bletillae), maltose according to weight ratio 1:3, adds Radix Ginseng weight 5～the water of 10 times, add medicated beer
Yeast, 36 DEG C of bottom fermentations 10 days, is warming up to fermentation liquid 95 DEG C of sterilizings, then it is little that fermentation liquid temperature rising reflux is extracted 4 after terminating
Time, extracting solution is by after residue filter, and concentrating under reduced pressure is concentrated solution, then is spray-dried by concentrated solution, obtains Pseudobulbus Bletillae (Rhizoma Bletillae) extraction of fermenting
Thing；
2nd step, after Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Scutellariae mixing, extracting in water, amount of water is 6 times of medical material weight, and extraction time is 3h,
Extracting temperature is 95 DEG C, after extracting solution leaches residue, through concentrating under reduced pressure, after drying, obtains medicinal substances extract；
3rd step, will fermentation bletilla striata extract, medicinal substances extract, Flos Inulae extract, hyaluronic acid, green tea extract, lemon extract
Oil, Decane-1,2-diol, Aloe glue, Herba Lysimachiae foenum-graeci quintessence oil, chamomile essential oil, vitamin E, carbomer, glycerol, essence, emulsifying agent, go
After ionized water mixing, it is warming up to 60～80 DEG C of stirrings, after letting cool, obtains skin moisture-keeping acne removing water.
Embodiment 3
A kind of skin moisture-keeping acne removing water, includes following component by weight: Radix Ginseng 3 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Scutellariae 15 parts,
Flos Inulae extract 0.2 part, hyaluronic acid 0.03 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, green tea extract 0.7 part, Fructus Citri Limoniae quintessence oil 0.08 part, 1,2-
Decanediol 0.03 part, Aloe glue 0.7 part, Herba Lysimachiae foenum-graeci quintessence oil 0.04 part, chamomile essential oil 0.02 part, vitamin E 0.8 part, card ripple
Nurse 3 parts, glycerol 7 parts, 0.15 part of essence, ceteareth-20 emulsifying agent 0.55 part, deionized water 70 parts.
Preparation method, comprises the steps:
1st step, mixes the Pseudobulbus Bletillae (Rhizoma Bletillae), maltose according to weight ratio 1:3, adds the water of Radix Ginseng weight 8 times, add medicated beer ferment
Mother, 32 DEG C of bottom fermentations 10 days, is warming up to fermentation liquid 92 DEG C of sterilizings, then is extracted 3 hours by fermentation liquid temperature rising reflux after terminating,
Extracting solution is by after residue filter, and concentrating under reduced pressure is concentrated solution, then is spray-dried by concentrated solution, obtains bletilla striata extract of fermenting；
2nd step, after Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Scutellariae mixing, extracting in water, amount of water is 6 times of medical material weight, and extraction time is 2h,
Extracting temperature is 92 DEG C, after extracting solution leaches residue, through concentrating under reduced pressure, after drying, obtains medicinal substances extract；
3rd step, will fermentation bletilla striata extract, medicinal substances extract, Flos Inulae extract, hyaluronic acid, green tea extract, lemon extract
Oil, Decane-1,2-diol, Aloe glue, Herba Lysimachiae foenum-graeci quintessence oil, chamomile essential oil, vitamin E, carbomer, glycerol, essence, emulsifying agent, go
After ionized water mixing, it is warming up to 60～80 DEG C of stirrings, after letting cool, obtains skin moisture-keeping acne removing water.
Reference examples 1
Difference with embodiment 3 is: the Pseudobulbus Bletillae (Rhizoma Bletillae) is without fermentation, but directly extracts.
A kind of skin moisture-keeping acne removing water, includes following component by weight: Radix Ginseng 3 parts, Radix Salviae Miltiorrhizae 12 parts, Radix Scutellariae 15
Part, Flos Inulae extract 0.2 part, hyaluronic acid 0.03 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 5 parts, green tea extract 0.7 part, Fructus Citri Limoniae quintessence oil 0.08 part, 1,
2-decanediol 0.03 part, Aloe glue 0.7 part, Herba Lysimachiae foenum-graeci quintessence oil 0.04 part, chamomile essential oil 0.02 part, vitamin E 0.8 part, card
Ripple nurse 3 parts, glycerol 7 parts, 0.15 part of essence, ceteareth-20 emulsifying agent 0.55 part, deionized water 70 parts.
Preparation method, comprises the steps:
1st step, after the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Scutellariae mixing, extracting in water, amount of water is 6 times of medical material weight, extraction time
Being 2h, Extracting temperature is 92 DEG C, after extracting solution leaches residue, through concentrating under reduced pressure, after drying, obtains medicinal substances extract；
2nd step, by medicinal substances extract, Flos Inulae extract, hyaluronic acid, green tea extract, Fructus Citri Limoniae quintessence oil, 1,2-decanediol,
After the mixing of Aloe glue, Herba Lysimachiae foenum-graeci quintessence oil, chamomile essential oil, vitamin E, carbomer, glycerol, essence, emulsifying agent, deionized water,
It is warming up to 60～80 DEG C of stirrings, after letting cool, obtains skin moisture-keeping acne removing water.
Use Hash scopometer 2100Q that the turbidity of skin acne removing water is characterized.
As can be seen from the table, after the Pseudobulbus Bletillae (Rhizoma Bletillae) is fermented, then carry out extraction and can effectively make composition therein be decomposed,
The clarity making health-care water improves.
Human body skin moisture content detects:
Randomly select 100 health volunteers, clean forearm with unified gentle cleaning agent before test and bend side skin, at constant ring
Sit quietly in border 30min, then detects each test position by digital skin moisture detector, is repeated 3 times respectively, show that it is average
Value；Then by the skin acne removing water prepared in above example and reference examples
People), often place's pilot region is 4 × 4cm2.Wherein, acne removing water washes away after being coated in skin surface 20min, and glycerol uses dropper to drip one
Drip, wipe after keeping 20min.
After washing away, 60min, 120min and 180min detect the most respectively at these positions.The meansigma methods that will every time detect
Deduct the measured value being this this position of period before not smearing.Experimental result sees following table.
Moisture content of skin (%) test result
As can be seen from the table, the acne removing water that the present invention prepares has preferably to skin moisturizing, effect of moisturizing, is better than
Glycerol, and contrasted by embodiment 3 and reference examples 1 it can be seen that can make it easier to after being fermented by the Pseudobulbus Bletillae (Rhizoma Bletillae) inhale
Receive, make moistening effect more preferable.
Blemish clearing gel efficacy test:
1. tester's data
Random embodiment 1～3 groups that patient is divided into, reference examples 1 group.1 group of 20 example of embodiment, age 18～34 years old, the mean age
23 years old；Man's 9 examples, female 11 example.2 group of 20 example of embodiment, age 16～35 years old, 22.5 years old mean age；Man's 12 examples, female 8 example.Implement
3 group of 20 example of example, age 16～38 years old, 21.2 years old mean age；Man's 10 examples, female 10 example.1 group of 20 example of comparative example, the age 15～36
Year, 22.5 years old mean age；Man's 11 examples, female 9 example.
2. method of testing and effect standard
With reference to " new Chinese medicine guideline of clinical investigations ", Evaluation of Synthetic Effect of Holistic is with skin lesion degree, skin lesion distribution, symptom, sign
Total mark calculate curative effect rate.Curative effect=(skin lesion counting after treatment front skin lesion counting-treatment)/treatment front skin lesion counting ×
100%.Cure: skin lesion disappears more than 90%, the most a little pigmentation；Effective: skin lesion disappears 60%～90%, and symptom alleviates；Have
Effect: skin lesion disappears 20%～60%, symptom is improved；Invalid: skin lesion disappears, and < 20%, clinical symptoms is not improved.Total effective rate=cure rate
+ obvious effective rate.Onset time judges: after medication, symptom alleviates, disappearing reaches the natural law of more than 20% and be onset time.
Using method: tester cleans after face outside at skin lesion and is coated with a thin layer health-care water, every day each 1 time sooner or later, Tu Hou
40min washes away, and the course for the treatment of is 3 weeks.Not take a shower, shave or strenuous exercise (such as causing perspiration) before 2 hours and 30 points afterwards
Use within clock.
3. result
As can be seen from the above table, the health-care water that the present invention provides has preferable anti-acne effect, ferments especially by by the Pseudobulbus Bletillae (Rhizoma Bletillae)
Afterwards, the absorption of medicine it is more beneficial for.
Claims (6)
1. a skin moisture-keeping acne removing water, it is characterised in that include following component by weight: Radix Ginseng 3～4 parts, red
Join 10～15 parts, Radix Scutellariae 14～16 parts, Flos Inulae extract 0.1～0.3 part, hyaluronic acid 0.02～0.05 part, the Pseudobulbus Bletillae (Rhizoma Bletillae) 4～7
Part, green tea extract 0.5～1 part, Fructus Citri Limoniae quintessence oil 0.05～0.1 part, Decane-1,2-diol 0.02～0.05 part, Aloe glue 0.5～1
Part, Herba Lysimachiae foenum-graeci quintessence oil 0.03～0.05 part, chamomile essential oil 0.02～0.03 part, vitamin E 0.5～1.2 parts, carbomer 2～
4 parts, glycerol 6～10 parts, essence 0.1～0.2 part, emulsifying agent 0.5～0.8 part, deionized water 50～80 parts.
Skin moisture-keeping acne removing water the most according to claim 1, it is characterised in that described emulsifying agent is that cetearyl alcohol gathers
Ether-20.
3. the preparation method of the skin moisture-keeping acne removing water described in claim 1, it is characterised in that comprise the steps: the 1st step,
The Pseudobulbus Bletillae (Rhizoma Bletillae), maltose are mixed according to weight ratio 1:3, adds Radix Ginseng weight 5～the water of 10 times, add beer yeast, 30
～36 DEG C of bottom fermentations 10 days, after terminating, fermentation liquid is warming up to 90～95 DEG C of sterilizings, then fermentation liquid temperature rising reflux is extracted, extract
Liquid is by after residue filter, and concentrating under reduced pressure is concentrated solution, then is spray-dried by concentrated solution, obtains bletilla striata extract of fermenting；2nd
Step, after Radix Ginseng, Radix Salviae Miltiorrhizae, Radix Scutellariae mixing, extracting in water, after extracting solution leaches residue, through concentrating under reduced pressure, after drying, obtain
Medicinal substances extract；3rd step, will fermentation bletilla striata extract, medicinal substances extract, Flos Inulae extract, hyaluronic acid, green tea extraction
Thing, Fructus Citri Limoniae quintessence oil, Decane-1,2-diol, Aloe glue, Herba Lysimachiae foenum-graeci quintessence oil, chamomile essential oil, vitamin E, carbomer, glycerol, essence,
After the mixing of emulsifying agent, deionized water, heat up stirring, after letting cool, obtains skin moisture-keeping acne removing water.
The preparation method of skin moisture-keeping acne removing water the most according to claim 3, it is characterised in that in the 1st described step, carry
The time of taking is 2～4 hours.
The preparation method of skin moisture-keeping acne removing water the most according to claim 3, it is characterised in that in the 2nd described step, add
The water yield is 6 times of medical material weight, and extraction time is 1～3h, and Extracting temperature is 90～95 DEG C.
The preparation method of skin moisture-keeping acne removing water the most according to claim 3, it is characterised in that in the 3rd described step, rises
The temperature of temperature stirring is 60～80 DEG C.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578326A (en) * | 2018-07-11 | 2018-09-28 | 贵州夜郎古国生物科技有限公司 | A kind of camellia oil face cream and preparation method thereof |
| CN112043666A (en) * | 2020-10-19 | 2020-12-08 | 湖南金昌生物技术有限公司 | Camellia pure dew for controlling oil and removing acne and preparation method thereof |
| CN112107523A (en) * | 2019-06-19 | 2020-12-22 | 东莞圣幸健康科技有限公司 | Moistening acne-removing composition and moistening acne-removing mask |
| CN113208944A (en) * | 2021-05-17 | 2021-08-06 | 广东一方制药有限公司 | Skin care composition and skin care product with moisturizing effect |
| CN117618306A (en) * | 2023-11-22 | 2024-03-01 | 天地慈(东莞)生物科技有限公司 | Relief repair composition and preparation method thereof |
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| CN112043666A (en) * | 2020-10-19 | 2020-12-08 | 湖南金昌生物技术有限公司 | Camellia pure dew for controlling oil and removing acne and preparation method thereof |
| CN113208944A (en) * | 2021-05-17 | 2021-08-06 | 广东一方制药有限公司 | Skin care composition and skin care product with moisturizing effect |
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