CN103690660B - Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof - Google Patents
Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof Download PDFInfo
- Publication number
- CN103690660B CN103690660B CN201310645460.5A CN201310645460A CN103690660B CN 103690660 B CN103690660 B CN 103690660B CN 201310645460 A CN201310645460 A CN 201310645460A CN 103690660 B CN103690660 B CN 103690660B
- Authority
- CN
- China
- Prior art keywords
- alopecia
- hair
- chinese medicine
- medicine composition
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 54
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 201000004384 alopecia Diseases 0.000 title abstract description 85
- 231100000360 alopecia Toxicity 0.000 title abstract description 79
- 210000004209 Hair Anatomy 0.000 title abstract description 70
- 238000002360 preparation method Methods 0.000 title abstract description 8
- 230000001172 regenerating Effects 0.000 title abstract 2
- 241000124033 Salix Species 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 73
- 230000003698 anagen phase Effects 0.000 claims description 26
- 230000003779 hair growth Effects 0.000 claims description 26
- 229940079593 drugs Drugs 0.000 claims description 17
- 239000000843 powder Substances 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 8
- 238000004064 recycling Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 6
- 239000012567 medical material Substances 0.000 claims description 6
- -1 and filter Substances 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 5
- 238000000605 extraction Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 4
- 239000006286 aqueous extract Substances 0.000 claims description 2
- 238000002481 ethanol extraction Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000002244 precipitate Substances 0.000 claims description 2
- 238000003809 water extraction Methods 0.000 claims description 2
- 208000004631 Alopecia Areata Diseases 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 13
- 230000003676 hair loss Effects 0.000 abstract description 5
- 240000003594 Eclipta prostrata Species 0.000 abstract description 2
- 230000001225 therapeutic Effects 0.000 abstract description 2
- 241000218218 Ficus <angiosperm> Species 0.000 abstract 1
- 231100000486 side effect Toxicity 0.000 abstract 1
- 230000003203 everyday Effects 0.000 description 18
- 210000004761 Scalp Anatomy 0.000 description 13
- 210000003734 Kidney Anatomy 0.000 description 12
- 210000004369 Blood Anatomy 0.000 description 10
- 239000008280 blood Substances 0.000 description 10
- 201000010099 disease Diseases 0.000 description 10
- 238000002347 injection Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- 210000003128 Head Anatomy 0.000 description 8
- 241000700159 Rattus Species 0.000 description 8
- 230000035617 depilation Effects 0.000 description 8
- 229960001712 Testosterone Propionate Drugs 0.000 description 7
- PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 description 7
- 210000000952 Spleen Anatomy 0.000 description 6
- 210000004185 Liver Anatomy 0.000 description 5
- 210000003491 Skin Anatomy 0.000 description 5
- 238000010254 subcutaneous injection Methods 0.000 description 5
- 239000007929 subcutaneous injection Substances 0.000 description 5
- 238000002560 therapeutic procedure Methods 0.000 description 5
- 206010000565 Acquired immunodeficiency syndrome Diseases 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 206010001766 Alopecia totalis Diseases 0.000 description 3
- 206010010356 Congenital anomaly Diseases 0.000 description 3
- 229960003067 Cystine Drugs 0.000 description 3
- 208000001840 Dandruff Diseases 0.000 description 3
- 240000000231 Ficus thonningii Species 0.000 description 3
- 210000003780 Hair Follicle Anatomy 0.000 description 3
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine zwitterion Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 208000008742 Seborrheic Dermatitis Diseases 0.000 description 3
- 210000002784 Stomach Anatomy 0.000 description 3
- 208000002271 Trichotillomania Diseases 0.000 description 3
- 210000002268 Wool Anatomy 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 3
- 235000008216 herbs Nutrition 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 230000001737 promoting Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000003797 telogen phase Effects 0.000 description 3
- 208000006572 Human Influenza Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010022000 Influenza Diseases 0.000 description 2
- OXNIZHLAWKMVMX-UHFFFAOYSA-N Picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 2
- 241000700157 Rattus norvegicus Species 0.000 description 2
- 206010039792 Seborrhoea Diseases 0.000 description 2
- LXMSZDCAJNLERA-ZHYRCANASA-N Spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 2
- 208000006379 Syphilis Diseases 0.000 description 2
- 210000001685 Thyroid Gland Anatomy 0.000 description 2
- 206010044625 Trichorrhexis Diseases 0.000 description 2
- 206010047642 Vitiligo Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000001154 acute Effects 0.000 description 2
- 201000005794 allergic hypersensitivity disease Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000004624 dermatitis Diseases 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 201000009910 diseases by infectious agent Diseases 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229940114148 picric acid Drugs 0.000 description 2
- 230000003014 reinforcing Effects 0.000 description 2
- 230000014860 sensory perception of taste Effects 0.000 description 2
- 229960002256 spironolactone Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 230000035917 taste Effects 0.000 description 2
- 229950002929 trinitrophenol Drugs 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010001767 Alopecia universalis Diseases 0.000 description 1
- 240000002216 Alternanthera philoxeroides Species 0.000 description 1
- 208000007502 Anemia Diseases 0.000 description 1
- 206010003549 Asthenia Diseases 0.000 description 1
- 208000006673 Asthma Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010003816 Autoimmune disease Diseases 0.000 description 1
- 241000522289 Bituminaria bituminosa Species 0.000 description 1
- 240000000218 Cannabis sativa Species 0.000 description 1
- 235000008495 Chrysanthemum leucanthemum Nutrition 0.000 description 1
- 244000192528 Chrysanthemum parthenium Species 0.000 description 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 description 1
- 208000001824 Congenital alopecia X-linked Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 241000218691 Cupressaceae Species 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 229960003957 Dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N Dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000668709 Dipterocarpus costatus Species 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 208000005679 Eczema Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 208000001780 Epistaxis Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 210000003746 Feathers Anatomy 0.000 description 1
- 206010016286 Febrile disease Diseases 0.000 description 1
- 210000001061 Forehead Anatomy 0.000 description 1
- 102100009876 GTF2H5 Human genes 0.000 description 1
- 101710043072 GTF2H5 Proteins 0.000 description 1
- 208000001786 Gonorrhea Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 206010018987 Haemorrhage Diseases 0.000 description 1
- 210000001624 Hip Anatomy 0.000 description 1
- 206010021067 Hypopituitarism Diseases 0.000 description 1
- 206010022114 Injury Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 210000004072 Lung Anatomy 0.000 description 1
- 206010025135 Lupus erythematosus Diseases 0.000 description 1
- 206010062049 Lymphocytic infiltration Diseases 0.000 description 1
- 206010025482 Malaise Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241000218231 Moraceae Species 0.000 description 1
- 210000000214 Mouth Anatomy 0.000 description 1
- 210000003205 Muscles Anatomy 0.000 description 1
- 206010052639 Nerve injury Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 235000019082 Osmanthus Nutrition 0.000 description 1
- 241000333181 Osmanthus Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 210000003516 Pericardium Anatomy 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 240000002924 Platycladus orientalis Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N Prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
- 241000196435 Prunus domestica subsp. insititia Species 0.000 description 1
- 241001446509 Psoralea Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010037844 Rash Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010072736 Rheumatic disease Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 229960002477 Riboflavin Drugs 0.000 description 1
- 241001278097 Salix alba Species 0.000 description 1
- 240000008158 Salix babylonica Species 0.000 description 1
- 235000002493 Salix babylonica Nutrition 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 206010040767 Sjogren's syndrome Diseases 0.000 description 1
- 206010040882 Skin lesion Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 206010043866 Tinea capitis Diseases 0.000 description 1
- 206010044008 Tonsillitis Diseases 0.000 description 1
- 208000004371 Toothache Diseases 0.000 description 1
- 206010044628 Trichothiodystrophy Diseases 0.000 description 1
- 208000003059 Trichothiodystrophy Syndromes Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003629 Vitamin B6 Natural products 0.000 description 1
- 229940011671 Vitamin B6 Drugs 0.000 description 1
- 208000001877 Whooping Cough Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000001058 adult Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 230000001396 anti-anti-diuretic Effects 0.000 description 1
- 230000000844 anti-bacterial Effects 0.000 description 1
- 230000003110 anti-inflammatory Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 231100000406 dermatitis Toxicity 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000001882 diuretic Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 231100001003 eczema Toxicity 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000029578 entry into host Effects 0.000 description 1
- 230000003628 erosive Effects 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 235000008384 feverfew Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 210000000442 hair follicle cell Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002439 hemostatic Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 230000003902 lesions Effects 0.000 description 1
- 201000009673 liver disease Diseases 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 201000005505 measles Diseases 0.000 description 1
- 201000009906 meningitis Diseases 0.000 description 1
- 230000002503 metabolic Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006011 modification reaction Methods 0.000 description 1
- 201000005935 monilethrix Diseases 0.000 description 1
- 230000004719 natural immunity Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 201000008875 nutrition disease Diseases 0.000 description 1
- 230000000050 nutritive Effects 0.000 description 1
- 230000003287 optical Effects 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 201000005702 pertussis Diseases 0.000 description 1
- 201000003192 photosensitive trichothiodystrophy Diseases 0.000 description 1
- 201000010830 physical disease Diseases 0.000 description 1
- 229960004618 prednisone Drugs 0.000 description 1
- 201000004681 psoriasis Diseases 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000552 rheumatic Effects 0.000 description 1
- 230000001835 salubrious Effects 0.000 description 1
- 230000001932 seasonal Effects 0.000 description 1
- 231100000444 skin lesion Toxicity 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000001502 supplementation Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 201000010874 syndrome Diseases 0.000 description 1
- BKVIYDNLLOSFOA-UHFFFAOYSA-N thallium Chemical compound [Tl] BKVIYDNLLOSFOA-UHFFFAOYSA-N 0.000 description 1
- 229910052716 thallium Inorganic materials 0.000 description 1
- 230000000472 traumatic Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 150000003697 vitamin B6 derivatives Chemical class 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Abstract
The invention discloses a traditional Chinese medicine composition for stopping alopecia and regenerating hair and a preparation method thereof. The traditional Chinese medicine composition for stopping alopecia disclosed by the invention is prepared from the following raw materials in parts by weight: ficus aerial root, willow hair, eclipta, cacumen biotae and fructus psoraleae. The traditional Chinese medicine composition disclosed by the invention has the obvious therapeutic effect to alopecia areata and alopecia seborrhoeica; furthermore, the traditional Chinese medicine composition is simple for preparation, convenient for use, rapid in effect and free from side effects and is capable of removing acomia worry for hair loss people.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to Chinese medicine composition of a kind of hair growth accelerating and preparation method thereof.
Background technology
Alopecia is Modern human populations one comparatively universal phenomenon, annoyings many young and promising personages.Because alopecia one affects personal image, two have impact on inter personal contact, the more serious psychology that also can affect hair loss patient.
The reason of alopecia has: nerve, cryptorrhea, trophism, physical property, chemical, infectivity, symptomatic, congenital, seasonal alopecia etc.Wherein the alopecia areata that causes of cryptorrheic seborrheic alopecia and natural immunity is comparatively common.
Seborrheic alopecia claimed male pattern alopecia in the past, male pattern alopecia, male alopecia, diffusivity alopecia, universality alopecia etc., its sick to heredity, androgen, seborrhea be relevant.Symptom is that scalp portion fat secretion is too much, and hair has greasy feeling.Clinical manifestation is the excessive spilling of patient's scalp fat, causes the greasy humidity of scalp, adds that dust and scurf mix, and within several days, does not wash hair just very dirty, and gives an offensive smell, especially all the more so when temperature height; Sometimes also to scratch where it itches inflammation with scalp, mainly because scalp is moist, the numerous raw infection of antibacterial causes seborrheic dermatitis.
Seborrheic alopecia is called as in the traditional Chinese medical science " post tineatonsurans " or " alopecia of damaging by worms " due to damp and hot invasion and attack skin, make nutritional disorder, space between skin and muscles is not solid, venation block, and the biochemical unfavorable Rhizoma Imperatae that causes of essence and blood does not cause alopecia admittedly, dialectically be: damp-heat in the spleen and stomach is (usually addicted to food, sweet fertilizer, hair cream wets, and squama is greasy, hair epidemic disease is itched, alopecia); Blood-deficiency and wind-dry (hair is dry, sparsely comes off, and squama stacks, and porrigo is itched).
Alopecia areata is a kind of non-cicatricial alopecia of autoimmunity, often betides the crinite position of health, and local skin is normal, no conscious sympton.Etiology unknown.Have lymphocytic infiltration at perifollicolar, and primary disease merges other autoimmune diseasees (as vitiligo, atopic dermatitis) sometimes, therefore think that the generation of primary disease may exist autoimmune pathogenesis at present.Heredodiathesis is also a key factor, may be relevant to HLA II type, and the case of 25% has family history.In addition, also may be relevant with endocrine disturbance with traumatic nerve injury, psychological problem, infection focus.
Alopecia areata can betide any age, but common with person between twenty and fifty, both sexes sickness rate no significant difference.Skin lesion shows as circle or the non-cicatricial alopecia of oval, at alopecia areata edge Chang Kejian " exclamation mark " sample hair.Hair comes off all or almost all, is called alopecia totalis.The all hair (comprising chaeta) of whole body all comes off, and is called general de-.Be also shown in row alopecia of crawling.Except without except hair, there are not other extremely in lesion skin.
The western medicine therapy of current seborrheic alopecia mainly by oral supplementation nutrition, or is coated with antiinflammatory outward:
(1) each 10 milligrams of vitamin B2 is taken, every day 3 times; Each 20 milligrams of vitamin B6, every day 3 times; Or each 3 of compound vitamin B, every day 3 times.
(2) each 50 milligrams of oral cystine, every day 3 times;
(3) acute popularity pathological changes person, can take each 10 milligrams of prednisone, every day 3 times, or each 1.5 milligrams of dexamethasone, every day 3 times, is used in conjunction 5-7 days.
The traditional Chinese medical science also has the multiple treatment side being used for the treatment of alopecia, but curative effect is all not too remarkable, or the hair of new life is very soft, easily comes off again.For solving the worry of alopecia personage, need the medicine that a kind of effective hair growth accelerating is provided.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition of hair growth accelerating;
Another object of the present invention is to provide a kind of preparation method of Chinese medicine composition of hair growth accelerating.
The object of the invention is by following technical scheme realize:
The Chinese medicine composition of hair growth accelerating of the present invention is prepared from by the raw material comprising following weight portion: Radix Aerio Fici Microcarpae 50-150 part, willow palpus 50-150 part, Herba Ecliptae 10-60 part, Cacumen Platycladi 10-60 part, Fructus Psoraleae 3-18 part.
The Chinese medicine composition of hair growth accelerating of the present invention, its preferred version is prepared from by the raw material comprising following weight portion: Radix Aerio Fici Microcarpae 80-120 part, willow palpus 80-120 part, Herba Ecliptae 20-50 part, Cacumen Platycladi 20-50 part, Fructus Psoraleae 5-15 part.
The Chinese medicine composition of hair growth accelerating of the present invention, its further preferred version is prepared from by the raw material comprising following weight portion: Radix Aerio Fici Microcarpae 100 parts, willow palpus 100 parts, Herba Ecliptae 30 parts, Cacumen Platycladi 30 parts, Fructus Psoraleae 10 parts.
The Chinese crude drug details adopted in the present invention is as follows:
Radix Aerio Fici Microcarpae: be the aerial root of moraceae plants Ficus microcarpa Linn. f.The whole year can adopt.Cut off aerial root, be bundled into wisp, dry.Another name: half a day hangs (" the SHENGCAO property of medicine standby want "), hang wind root, Ficus microcarpa Linn. f must (" south of the Five Ridges gather medicinal herbs record "), Ficus microcarpa Linn. f hangs palpus (" Guangdong Chinese medicine ").Nature and flavor: pained are flat.Function cures mainly: expelling wind and clearing away heat, promoting blood circulation and detoxication.Control influenza, pertussis, measles without adequate eruption, tonsillitis, eye conjunctivitis, eruptive disease is suffered from abdominal pain, rheumatic ostalgia, epistaxis, stranguria with blood, traumatic injury.
Willow palpus: be the root hair of Salicaceous Plants Salix babylonica L..Another name: water willow palpus (" experiment of TCM research "), red dragon palpus (" Revision and Addition Tian Bao book on Chinese herbal medicine "), point water father-in-law (" conventional glossary of Herbs and Drugs among the people "), Green Dragon palpus (" Traditional Chinese Medicine in Sichuan will ").Nature and flavor: bitter, cold.Function cures mainly: diuretic, treating stranguria, dispels the wind, dehumidifying.Control gonorrhea, nebulousurine, edema, jaundice, rheumatalgia, yellow fluid eczema, toothache, scald.
Herba Ecliptae: be the herb of feverfew Eclipta prostrata, because when crumpling its stem and leaf, the juice of visible black color flows out, so cry again " tusche grass ".Flavour of a drug: cold in nature.There is invigorating the liver and kidney, yin nourishing effect.Can stop blooding, growing and blacking hair, liver and kidney tonifying.
Cacumen Platycladi: the browse of Cupressaceae plant (Platycladus orientalis (L.) Franco).Medical material Cacumen Platycladi Duo You branch, little and different in size, be flakey.Color is bronzing.The visible leaf in surface mutually to life, section yellow-white.Quality is crisp, easily fractureed.Feeble QI is fragrant, and the one in the blood-cooling hemostatic of bitter and puckery flavor Chinese medicine hemorrhage, has effect that hemostasis, black beard and hair, cough-relieving are breathed heavily.
Fructus Psoraleae: Arabic Psoralea pulse family (Psoralea bituminosa L.).Acrid in the mouth; Bitter; Warm in nature.Return kidney, pericardium, spleen, stomach, lung meridian.Function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea; Outer for vitiligo; Speckle is bald; Psoriasis.
Another aspect of the present invention there is provided the preparation method of inventive compound, and active ingredient of Chinese herbs of the present invention adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from:
Scheme one: get whole raw medicinal material, be ground into coarse powder, add the soak with ethanol 20-60 days that concentration expressed in percentage by volume is 50-80%, ethanol consumption is crude drug gross weight 60-100 times, soak filters, and filtrate recycling ethanol, to being 40-60% containing amount of alcohol, leaves standstill 20-30 days, filter, obtain described active component.
The preparation scheme of scheme one is preferably:
Be ground into coarse powder, add the soak with ethanol 30 days that concentration expressed in percentage by volume is 60%, ethanol consumption is crude drug gross weight 80 times, and soak filters, and filtrate recycling ethanol, to being 40% containing amount of alcohol, leaves standstill 30 days, filters, obtains described active component.
Scheme two: get whole raw medicinal material, be ground into coarse powder, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 8-10 of medical material total amount doubly, extraction time is 2-4 hour, merge extractive liquid, and filter, filtrate is condensed into fluid extract, obtains active component.
Scheme three: all raw medicinal materials, are ground into coarse powder, extracting in water, Aqueous extracts precipitate with ethanol, reclaim ethanol, and extracting solution merges distillate, and mixing, obtains active component.
The traditional Chinese medical science thinks that hair is main relevant to blood and kidney essense, hair is the sign of blood condition, essence of the kidney being reflected on the hair, and kidney qi declines, falling out, send out morning in vain.The source of nutrition of hair is in blood, and its growth power then root, in kidney essense, has the hair when body essence and blood fills only and just shows pitch-black tough.Otherwise work as deficiency of the liver and kindey, deficiency of qi and blood, then essence does not change blood, blood not hair care, root of hair is hollow and come off, bleach, and hair jewelry, expensive clothing and other valuables are easily broken, and occur various aging phenomenon.And the inducement of seborrheic alopecia is the imbalance of internal body taste, damp and hotly grows thickly, just showing fat secretion outside excessive---face bellding light, scalp pomade is large, dandruff is many.
Radix Aerio Fici Microcarpae and willow palpus clearing heat and expelling damp in side of the present invention, fortune strengthening the spleen and stomach, from Sources controlling fat secretion, makes scalp pomade dandruff reduce, and scalp is salubrious, and hair follicle cell draws abundant nutrition and smooth and easy breathing, thus stops alopecia; After deliberation, contained by Herba Ecliptae, alligator weed lactone, nor-alligator weed lactone effectively can promote hair cell growth; Herba Ecliptae, Cacumen Platycladi, Fructus Psoraleae nourishing the liver and kidney, invigorating kidney-YANG, spleen reinforcing be empty, improve head blood microcirculation, thus ensure internal body by abundant nutrient distribution to the crown, and be transported to hair follicle smoothly, and hair follicle is nourished, clear-cutting forestland life.We are by clearing heat and expelling damp first alopecia-stopping, then nourishing the liver and kidney, and hair growth promoting hair color, in side, each medicine matches suitable, coordinates mutually, has good curative effect to seborrheic alopecia and alopecia areata.
The Chinese medicine composition of a kind of hair growth accelerating provided by the invention has the following advantages:
1, the present invention and positive drug group all cause ectillotic rat to have extremely significant anti-avulsion effect to injection testosterone propionate injection, point out Clinical practice of the present invention can effective hair growth.
2, the present invention and the treatment situation of Western medicine group to patient's alopecia have pole significant difference (
p< 0.01), clinical treatment effective percentage of the present invention is 91.7%, and Western medicine group is 39.4%.Between the present invention 10 years, the patient of clinical treatment grows black coarse wool and sends out to follow up a case by regular visits to and have 97 examples without recurrence in more than 2 years, show that the present invention has good hair growth accelerating effect, and be far superior to prior art.
3, therapeutic process of the present invention does not find the phenomenon such as allergy, exception, and Clinical practice safety is high.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted.
Embodiment 1
Get Radix Aerio Fici Microcarpae 100g, willow must 100g, Herba Ecliptae 30g, Cacumen Platycladi 30g, Fructus Psoraleae 10g.Be ground into coarse powder, add the soak with ethanol 30 days that concentration expressed in percentage by volume is 60%, ethanol consumption is crude drug gross weight 80 times, and soak filters, and filtrate recycling ethanol, to being 40% containing amount of alcohol, leaves standstill 30 days, filters, obtains described active component.
Embodiment 2
Get Radix Aerio Fici Microcarpae 50g, willow must 50g, Herba Ecliptae 10g, Cacumen Platycladi 10g, Fructus Psoraleae 2g.Be ground into coarse powder, add the soak with ethanol 60 days that concentration expressed in percentage by volume is 50%, ethanol consumption is crude drug gross weight 60 times, and soak filters, and filtrate recycling ethanol, to being 40% containing amount of alcohol, leaves standstill 30 days, filters, obtains described active component.
Embodiment 3
Get Radix Aerio Fici Microcarpae 150g, willow must 150g, Herba Ecliptae 60g, Cacumen Platycladi 60g, Fructus Psoraleae 18g.Be ground into coarse powder, add the soak with ethanol 20 days that concentration expressed in percentage by volume is 80%, ethanol consumption is crude drug gross weight 100 times, and soak filters, and filtrate recycling ethanol, to being 60% containing amount of alcohol, leaves standstill 20 days, filters, obtains described active component.
Embodiment 4
Get Radix Aerio Fici Microcarpae 80g, willow must 80g, Herba Ecliptae 20g, Cacumen Platycladi 20g, Fructus Psoraleae 5g.Be ground into coarse powder, with 40% alcohol reflux 2 times, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, and each extraction time is respectively 4 hours, 2 hours, merge extractive liquid, and filter, filtrate is condensed into fluid extract, obtains active component.
Embodiment 5
Get Radix Aerio Fici Microcarpae 120g, willow must 120g, Herba Ecliptae 50g, Cacumen Platycladi 50g, Fructus Psoraleae 15g.Be ground into coarse powder, extracting in water 3 times, three amount of water are equivalent to 12 times, 8 times, 6 times of medical material gross weight respectively, each extraction time is 3 hours, 2 hours, 1 hour, merge extractive liquid, filters, when filtrate is concentrated into 70 DEG C, relative density is the clear paste of 1.10, and the percent by volume adding clear paste weight 3 times is the ethanol of 95%, stirs evenly, leave standstill 24 hours, filter, filtrate is recycled to ethanol, filters, filtrate is condensed into fluid extract, obtains active component.
Embodiment 6
Get Radix Aerio Fici Microcarpae 80g, willow must 80g, Herba Ecliptae 20g, Cacumen Platycladi 20g, Fructus Psoraleae 5g.Be ground into coarse powder, with 80% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 8 times of medical material total amount, each extraction time is respectively 3 hours, 2 hours, 2 hours, merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains active component.
Embodiment 7
Get Radix Aerio Fici Microcarpae 100g, willow palpus 120g, Herba Ecliptae 30g, Cacumen Platycladi 20g, Fructus Psoraleae 18g, above 5 tastes, clean rear drying, pulverizing, cross 80-100 mesh sieve, obtain powder of the present invention.
alopecia effect experiment
1, experiment material
(1) animal
Wistar rat, male and female half and half, body weight 200 ± 20g, buys from Guangxi Medical University's Experimental Animal Center (production licence number: SCXK osmanthus 2009-0002).
(2) medicine and reagent
Embodiment of the present invention 1-5, normal saline, 3% picric acid solution, testosterone propionate injection, Spironolactone Tablets.
2, experiment grouping
Wistar rat is divided at random 8 groups: embodiment 1-5 group, blank group, model control group, positive drug group, often organizes 10, male and female half and half, totally 80.
3, experimental technique
(1) modeling and administration
Each group of rat all chooses the hair of back 9cm × 7cm area, and the picric acid solution stained yellow with 3% is to determine district of losing hair or feathers.
Blank group: every day, gavage gave equal-volume normal saline, and after neck subcutaneous injection equal-volume normal saline, 1 times/day;
Model control group: every day, gavage gave equal-volume normal saline, and after neck subcutaneous injection testosterone propionate injection 5mg/ (kgd), 1 times/day;
Positive drug group: every day, gavage gave spironolactone suspension 9mg/kg, and after neck subcutaneous injection testosterone propionate injection 5mg/ (kgd), 1 times/day;
Embodiment 1-3 group: give embodiment 1-3 medicine respectively every day and be coated with outward, and after neck subcutaneous injection testosterone propionate injection 5mg/ (kgd), 1 times/day.
Embodiment 4-5 group: every day, gavage gave embodiment 4-5 medicine respectively, and after neck subcutaneous injection testosterone propionate injection 5mg/ (kgd), 1 times/day.
(2) index observing
In modeling and administration after 4 weeks, upper for rat metabolic cage is raised separately, observe rat dyed hair every day and to come off situation record, comprise the yellow alopecia quantity of dye and dyeing district's alopecia situation.By table 1, integral estimation is carried out to dyeing district's alopecia situation.
Table 1 rat depilation situation ranking criterion
4, experimental result
The each pharmaceutical intervention of table 2 on Hair of Rats come off quantity impact (n=10,
± s)
Note: compare with blank group, * P < 0.05, * * P < 0.01; Compare with model control group,
▲ ▲p < 0.01.
The each pharmaceutical intervention of table 3 on rat depilation district depilation situation impact (n=10,
± s)
Note: compare with blank group, * * P < 0.01; Compare with model control group,
▲ ▲p < 0.01.
Conclusion: the present invention and positive drug group all cause ectillotic rat to have extremely significant anti-avulsion effect to injection testosterone propionate injection, points out Clinical practice of the present invention can effective hair growth.
clinical trial
Clinical observation is carried out to the curative effect of the anti-alopecia of the present invention, by contrasting take medicine the alopecia situation of Patients Before And After, effect of alopecia areata areal analysis hair growth accelerating of the present invention.
1 diagnosis basis
1.1 age of onset:
1. during birth or infantile period there is bald originator, mostly be heritability or congenital factor causes.If grow again after alopecia, can be physiological;
2. childhood onset person, common tinea capitis, trichotillomania etc.;
3. teenager and adolescence send out patient, and common mechanicalness alopecia, alopecia areata, bifurcated are sent out, cast hair, hair corrode, pinniform or trichoclasia etc.;
4. the woman in lactation period person of appearance, mostly is puerperal alopecia, and also there is similar alopecia climacteric; 5. late adult onset person, common hair dyeing dermatitis, seborrheic alopecia etc.
1.2 onset processes:
1. sudden onset person mostly is alopecia areata, trichotillomania etc.;
2. slowly play that patient is common male pattern alopecia, senile alopecia etc.;
3. some patients first have other physical disease, and alopecia or alopecia are one of symptom of these diseases, or the telogen effluvim that these diseases increase suddenly after being ill;
4. contact antitumor drug or some is as containing the chemical agent such as thallium, lead, easily occur growing period alopecia.
5. patient's hair is originally normal, and after some disease occurs scalp, the hair come off is always not long, may belong to Cicatricial baldness.
1.3 bald (taking off) send out scope:
1. alopecia generalisata is more common in puerperal alopecia, abnormal thyroid function, hypopituitarism, lupus are sent out, sjogren syndrome, anemia, hepatopathy, malnutrition etc., and febrile disease as ileotyphus, pneumonia, meningitis, influenza etc. after being ill.
2. the alopecia of forehead both sides temples portion, head, mostly is hair style alopecia or male pattern alopecia.
3. occipitalia alopecia belongs to physical property alopecia more, mainly by scalp local with caused by the curtain frottage such as coarse medicated pillow.
4. the alopecia at women's scalp edge, the hair style alopecia of many genus or traction alopecia, hair follicle occurs that inflammation is comparatively common.
5. hair speckle flaking, can be thought of as alopecia areata, trichotillomania.
6. alopecia totalis or alopecia universalis should be specifically noted that the probability of congenital alopecia, alopecia areata.
1.4 alopecia quantity:
1. the hair number come off every day is less than 100, and majority belongs to physiologic alopecia.
2. a large amount of alopecia in the short time, form acute, multiple alopecia areata, even alopecia totalis, mostly is growing period alopecia;
But 3. fall ill in 1-6 months after birth, hair all comes off and no longer grows, and should consider congenital total alopecia or some heredopathia syndromes;
4. telogen effluvim is then generally in progress comparatively slow, and the hair come off is no more than 50%.
1.5 hair forms:
1. many trichopathies have special hair form, as bifurcated send out, cystose is sent out, the erosion of monilethrix, cast hair, hair, hair subulate fracture, pinniform trichorrhexis, trichoclasia, trichorrhexis invaginata, trichothiodystrophy etc.
2. the growing period alopecia disease such as alopecia areata, the hair near-end ball top atrophy that it comes off attenuates in exclamation mark (! ) sample.
3. telogen effluvim disease, the hair near-end that it comes off is bar-shaped or pestle shape.Observe hair form major part to recognize with magnifier, also have part to need with optical microscope, ultramicroscope just can be made a definite diagnosis even.
2 auxiliary examinations
2.1 Endocrinological inspections: check estrogen level, thyroid function etc.
2.2 other: the disease examinations such as Analysis of Nutritive Status, systemic lupus erythematosus (sle), acquired immune deficiency syndrome (AIDS), syphilis.
3 alopecia degree diagnostic criterias:
3.1 alopecia area scorings: 0 is divided into without alopecia alopecia phenomenon (recovering > 80%); 1 is divided into alopecia area <6cm2(to recover > 60%); 2 are divided into alopecia area 6-15cm
2(recovering > 30%); 3 are divided into alopecia area >15cm
2(recovering < 30%).
3.2 hair growth promoting situations scorings: 0 be divided into basic long less than kainogenesis; 1 is divided into and grows less new; 2 are divided into and grow the new hair of part; 3 are divided into and grow more new hair, comparatively have larger improvement before treatment.
2 case selections
At 20 ~ 60 years old age, be ready acceptance 8 weeks therapists, signature enters clinical research Informed Consent Form person.
3 medicines
Experimental group: embodiment 1
Matched group: cystine
4 curative effect determinate standards
Basic healing: hair recovers area > 80%, depilation phenomenon disappears, and hair obviously grows;
Effective: hair recovers area > 60%, and depilation phenomenon obviously disappears, hair starts growth;
Take a turn for the better: hair recovers area > 30%, and depilation phenomenon disappears substantially, and hair slowly grows;
Invalid: hair recovers area < 30%, and depilation phenomenon still exists.
5 clinical grouping and Therapeutic Method
Enter to organize the routine patient of case 386, man 266 example, female 120 example; Average about 39 years old; All patients all fill in self-questionnaire survey, and are diagnosed as hair loss patient through inspections such as head hair features, and get rid of the alopecia because the diseases such as systemic lupus erythematosus (sle), acquired immune deficiency syndrome (AIDS) and syphilis cause.Case is divided into two groups at random, carries out double-blind to experimenter, Self-controlled study before and after treatment.
Therapeutic Method:
Experimental group: the embodiment of the present invention 1, is coated with the skin place of alopecia, every day 3-4 time.
Matched group: each 50 milligrams of oral cystine, every day 3 times.
6 results
After in experimental example group case, most of patient takes the embodiment of the present invention 1, depilation phenomenon reduces or disappears, and before randomized controlled treatment, hair loss state finds on inspection, and after treatment, hair growth is good.
Table 4: alopeciaing therapeutic effect
| Group | Number of cases | Be almost recovered | Effective | Take a turn for the better | Invalid | Total effective rate (%) |
| Experimental group | 193 | 97 | 39 | 41 | 16 | 91.7* |
| Matched group | 193 | 22 | 51 | 44 | 76 | 39.4 |
Note: experimental group compares with matched group, *
p< 0.01.
As seen from the above table, the present invention and the treatment situation of Western medicine group to patient's alopecia have pole significant difference (
p< 0.01).Between the present invention 10 years, the patient of clinical treatment grows black coarse wool and sends out to follow up a case by regular visits to and have 97 examples without recurrence in more than 2 years, and therapeutic process does not find the phenomenon such as allergy, exception, shows that the present invention has good hair growth accelerating effect.
Model case:
1, Wang, man, 40 years old.Alopecia 9 months, and readme head oxygen, check and see that its scalp light is impractical micro-swollen, hair is sparse denumerable, and residual silk one touches namely to fall, tired.Through suggestion, the embodiment of the present invention 1 is adopted to treat.Medicine for external application 12 days, readme alopecia reduces, and head pruritus gradually stops, and hair is obviously tough and tensile, does not namely take off like it last touching; Medication 28 days, readme alopecia is about every day 18 (genus physiologic alopecia), does not occur head pruritus again, checks that seeing that its scalp is sparse grows new sending out; With the present invention after 6 weeks, this patient's hair significantly increases, and alopecia district has born new sending out, and hair is pliable and tough; After treatment terminates, each symptom of this patient has recovered normal.
2, what certain, female, 46 years old.Alopecia 5 months, readme is susceptible to lose temper due to restlessness over the past half year, and alopecia is many, and every day can reach hundred, and check and see that its hair is sparse, hair is sallow, touches and namely falls.Through suggestion, the embodiment of the present invention 2 is adopted to treat.Affected part of exterior coating 9 days, alopecia reduces; Medication 21 days, patient's readme alopecia obviously reduces (every day about come off 40-60 root), checks that to see that its hair presents soft bright, withered not like before treatment.With the present invention after 6 weeks, this patient's hair is day by day in great numbers, and hair jade-like stone is bright; After treatment terminates, the abnormal obscission of this patient's hair disappears, and spirit is straightforward.
3, old x bright, male, 42 years old, head alopecia areata 3 position, existing 2 years, once used ZHANGGUANG 101 regenerate clear 3 months invalid, also invalid with crossing Han Yong 9+9 4 months, be coated with the embodiment of the present invention 3 is outer, within 7 days, just start afterwards to have grown fine, soft fur, within 20 days, become thick black wool, within 30 days, just overgrow with the dark hair of tubbiness.
4, land x pine, man 46 years old, head 1-5cm size alopecia areata 5 place such as not, used ZHANGGUANG 101 to regenerate clear, 9+9 and many in brand always use 3 invalid every year, treat by the embodiment of the present invention 4, within 9 days, start long fine, soft fur, the normal dark hair of 40 days total lengths.
5, Bears x its, man, 46 years old, to send out sparse glossy for the alopecia of seborrhea surname, the crown once with the earthwork, secret recipe treatment, with ZHANGGUANG 101 treat 4 months invalid, after Korea Spro is invalid with 9+9 hair growth promoter 2 months, treat by the embodiment of the present invention 5, start after 20 days to grow delicate hair.
Claims (8)
1. a Chinese medicine composition for hair growth accelerating, is characterized in that it is prepared from by the raw material of following weight portion: Radix Aerio Fici Microcarpae 50-150 part, willow palpus 50-150 part, Herba Ecliptae 10-60 part, Cacumen Platycladi 10-60 part, Fructus Psoraleae 3-18 part.
2. the Chinese medicine composition of hair growth accelerating as claimed in claim 1, is characterized in that it is prepared from by the raw material of following weight portion: Radix Aerio Fici Microcarpae 80-120 part, willow palpus 80-120 part, Herba Ecliptae 20-50 part, Cacumen Platycladi 20-50 part, Fructus Psoraleae 5-15 part.
3. the Chinese medicine composition of hair growth accelerating as claimed in claim 2, is characterized in that it is prepared from by the raw material of following weight portion: Radix Aerio Fici Microcarpae 100 parts, willow palpus 100 parts, Herba Ecliptae 30 parts, Cacumen Platycladi 30 parts, Fructus Psoraleae 10 parts.
4. the Chinese medicine composition of the hair growth accelerating as described in one of claim 1-3, is characterized in that its active component adopts the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. the Chinese medicine composition of hair growth accelerating as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
Get whole raw medicinal material, be ground into coarse powder, add the soak with ethanol 20-60 days that concentration expressed in percentage by volume is 50-80%, ethanol consumption is crude drug gross weight 60-100 times, and soak filters, and filtrate recycling ethanol is 40-60% to containing amount of alcohol, leave standstill 20-30 days, filter, obtain described active component.
6. the Chinese medicine composition of hair growth accelerating as claimed in claim 5, is characterized in that its active component is prepared from by the following method:
Get whole raw medicinal material, be ground into coarse powder, add the soak with ethanol 30 days that concentration expressed in percentage by volume is 60%, ethanol consumption is crude drug gross weight 80 times, and soak filters, and filtrate recycling ethanol is 40% to containing amount of alcohol, leave standstill 30 days, filter, obtain described active component.
7. the Chinese medicine composition of hair growth accelerating as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
Get whole raw medicinal material, be ground into coarse powder, with 40-80% alcohol reflux 2-3 time, each ethanol consumption be the 8-10 of medical material total amount doubly, extraction time is 2-4 hour, merge extractive liquid, and filter, filtrate is condensed into fluid extract, obtains active component.
8. the Chinese medicine composition of hair growth accelerating as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
Get whole raw medicinal material, be ground into coarse powder, extracting in water, Aqueous extracts precipitate with ethanol, reclaim ethanol, extracting solution merges distillate, and mixing, obtains active component.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310645460.5A CN103690660B (en) | 2013-12-05 | 2013-12-05 | Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310645460.5A CN103690660B (en) | 2013-12-05 | 2013-12-05 | Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103690660A CN103690660A (en) | 2014-04-02 |
| CN103690660B true CN103690660B (en) | 2015-06-03 |
Family
ID=50352430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310645460.5A Active CN103690660B (en) | 2013-12-05 | 2013-12-05 | Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103690660B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104208187A (en) * | 2014-07-27 | 2014-12-17 | 杨通神 | Preparation method of hair-growing solution |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727595A (en) * | 2012-07-04 | 2012-10-17 | 重庆港轶生物科技有限公司 | Chinese compound hair growth promoting composition and preparation method thereof |
| CN103202790A (en) * | 2013-05-03 | 2013-07-17 | 郭宏刚 | Purely natural shampoo |
| CN103223158A (en) * | 2013-05-21 | 2013-07-31 | 辛舒畅 | External medicine for treating alopecia |
-
2013
- 2013-12-05 CN CN201310645460.5A patent/CN103690660B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727595A (en) * | 2012-07-04 | 2012-10-17 | 重庆港轶生物科技有限公司 | Chinese compound hair growth promoting composition and preparation method thereof |
| CN103202790A (en) * | 2013-05-03 | 2013-07-17 | 郭宏刚 | Purely natural shampoo |
| CN103223158A (en) * | 2013-05-21 | 2013-07-31 | 辛舒畅 | External medicine for treating alopecia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103690660A (en) | 2014-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102178844B (en) | Oral Chinese medicine preparation for treating gum swelling and pain and preparation method thereof | |
| CN100353983C (en) | Chinese medicine preparation for reducing sugar | |
| CN103719498A (en) | Immunity-enhancing sealwort health-care tea and preparation method thereof | |
| CN103734428A (en) | Glossy-privet-fruit health-care tea for improving immunity and preparation method of tea | |
| CN103719491B (en) | A kind of sealwort invigorating the spleen moistening lung health protection tea and preparation method thereof | |
| CN105597071A (en) | Traditional Chinese medicine composition for treating piglet iron-deficiency anemia and preparing method thereof | |
| CN106359720A (en) | Health protection tea for clearing heat from throat and moistening lung and preparation method thereof | |
| CN106539083A (en) | It is a kind of to be used to prevent and treat diabetic retinopathy, alleviate asthenopic compositionss | |
| CN104305205B (en) | A kind of Semen Cuscutae oral liquid improving immunity and preparation method thereof | |
| CN102000164B (en) | Traditional Chinese medicine composition for treating psoriasis and preparation method thereof | |
| CN103705638B (en) | Chinese medicine composition of a kind of alleviating asthenopia and preparation method thereof | |
| CN104489172A (en) | Acanthopanax health tea for improving immunity and preparation method thereof | |
| CN104857238A (en) | Traditional Chinese medicine for treating spleen-kidney-yang deficiency type iron-deficiency anemia and preparation method | |
| CN107158223A (en) | For clearing heat and detoxicating Chinese medicine preparation with anti-inflammatory and preparation method thereof | |
| CN107468961A (en) | Phalacrosis prevention and hair generation Traditional Chinese medicinal spray and preparation method thereof | |
| CN107334894A (en) | A kind of composition for treating alopecia seborrheica | |
| CN105943617A (en) | Application of whole hemp extract in preparation of anti-hepatitis drugs | |
| CN104306659B (en) | A kind of Chinese medicine composition for treating diabetes B | |
| CN103690660B (en) | Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof | |
| CN103719496B (en) | A kind of leaves of Hawthorn lowering blood-fat and reducing weight health protection tea and preparation method thereof | |
| CN103705860B (en) | A kind of Chinese medicine composition for the treatment of infant jaundice and preparation method thereof | |
| CN104644967A (en) | Pharmaceutical composition for treating I-type diabetes and application thereof | |
| KR101048939B1 (en) | Method for producing product for promoting hair growth | |
| CN104491692A (en) | Traditional Chinese medicine preparation for preventing and treating liver diseases and production method thereof | |
| CN100372557C (en) | Oral liquid capable of raising human body anoxia tolerance and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: LIUZHOU CAOZIJI BIO-TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: GUANGZHOU JINCHUAN GUCAO BIOTECHNOLOGY CO., LTD. Effective date: 20150512 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20150512 Address after: 545025 the Guangxi Zhuang Autonomous Region Liuzhou City three road Liunan District Hang vision character building 1 unit C6 No. 4-3 Applicant after: Huang Rong Applicant after: The lucky bio tech ltd of Liuzhou grass seed Address before: 545025 the Guangxi Zhuang Autonomous Region Liuzhou City three road Liunan District Hang vision character building 1 unit C6 No. 4-3 Applicant before: Huang Rong Applicant before: GUANGXI JINCHUANGUCAO BIOLOGICAL SCIENCE & TECHNOLOGY CO., LTD. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |