CN101829182A

CN101829182A - Medicament for treating prostatic diseases

Info

Publication number: CN101829182A
Application number: CN201010118321A
Authority: CN
Inventors: 杨勇
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-03-04
Filing date: 2010-03-04
Publication date: 2010-09-15
Anticipated expiration: 2030-03-04
Also published as: CN101829182B

Abstract

The invention relates to a medicament for treating prostatic diseases and provides a medicament for treating prostatic diseases by adopting a method for improving the testosterone levels of human bodies, resisting bacteria and eliminating inflammations, reinforcing immunities and inducing diuresis for treating strangurtia, in particular a target medicament of the invention is realized by adopting the pharmacological properties of Tongkat Ali and propolis. The medicament is prepared from the Tongkat Ali, the propolis, ginseng and Eucommia ulmoides. The medicament has the advantages of relaxing tendons and activating collaterals, nourishing kidneys and tonifying qi, improving and regulating the immunologic function of human bodies, resisting the bacteria and eliminating the inflammations and inducing diuresis for treating strangurtia.

Description

A kind of medicine for the treatment of prostatosis

Affiliated technical field

The present invention relates to a kind of Chinese medicine medicine for the treatment of prostatosis.

Background technology

Prostatosis is more and more perplexing people, and its sickness rate height, disease time are long, presents the trend of rejuvenation in recent years again, and different prostatitis patients can show as different comprehensive symptoms clinically, and these syndromes respectively have its unique cause of disease again.Though at present medically the cause of disease of most of chronic prostatitiss is still lacked comprehensive and accurate understanding, therapeutic effect is also not fully up to expectations, studies show that in recent years, the generation of chronic prostatitis and following five kinds of factors are closely related.(1) congestion of prostate, the hyperemia that various different reasons cause is passive hyperemia particularly, is prostatitic important paathogenic factor.Patient's morbidity often is not because bacterial infection or microorganism invasion cause, but can form inflammatory reaction and bring out prostatitis.(2) the urine stimulation medically claims the urine stimulation to be chemical factor.Contain multiple Acidity of Aikalinity chemical substance in the urine,, when causing the damage of too high, the ducts of prostate gland opening part of back urethra pressure, will cause zest chemical substance such as uric acid to backflow and enter in the prostate, bring out chronic prostatitis as patient's local nerve endocrine disturbance.Solving countermeasure is to adopt acid-base value and the antiinflammatory of regulating urine.(3) various microorganisms of cause pathogeny imcrobe infection such as antibacterial, protozoon, fungus, virus etc. all can become and cause the prostatitic source of infection, wherein again with antibacterial for the most common, as gonococcus, non-gonococcus etc.The route of entry of antibacterial mainly contains three kinds.The one, hematogenous infection is found clinically, and bacterial prostatitis is because due to the infected by microbes more than 90%.The 2nd, lymph infects, and can infect prostate by the lymph pipeline such as the inflammation of lower urinary tract infection and colon, rectum, produces inflammation.The 3rd, direct extension, when the male urinated, urine will be passed through prostate, and the antibacterial in the urine can directly enter prostate, thereby causes prostate to infect.Solving countermeasure is to adopt antibiotic therapy, cooperates medicine among clearing away heat-damp and promoting diuresis, the blood circulation promoting and blood stasis dispelling simultaneously.(5) the immunity factor studies show that, chronic prostatitis and autoimmune factor have certain relation.There is the expert once on some arthritis patients' body, to find the existence of " anti-prostate antibody ".This class patient produces anti-prostate antibody because of congenital or acquired immunity defective often, thereby causes the prostata tissue damage.Find clinically, also can cause inflammation certain viral anaphylaxis.Particularly some human body patient lower for the resistance is higher to the sensitivity of virus, easily brings out chronic prostatitis.Solving countermeasure is to adopt immunity, anaphylaxis caused by factors prostatitis, and utilization Chinese medicine is regulated immunologic function.

Along with the pay attention to day by day of country to modernization of cmm, the raising of people's health care consciousness, advocate natural drug, green medicine and Western medicine kind toxic side effects greatly people find gradually, adopt the Chinese medicine preparation of natural drug that disease is treated, become the first-selection of people disease treatment.The Chinese medicine preparation of treatment urinary system infection is more at present, as secrete preparations such as drenching clearing capsule, the logical sheet of urinary tract, Cortex Phellodendri capsule, money blade, infirmity clear sheet, MINIAONING KELI, clearing heat and freeing strangury capsule and SANJIN PIAN, from tcm theory, existing above Chinese medicine preparation, primary symptom difference separately, research and development are used for the treatment of the Chinese medicine preparation that the urinary system infection tcm diagnosis is the pyretic stranguria disease, have obtained positive effect for the treatment by Chinese herbs of urinary system infection disease, enrich the pools of traditional Chinese medicine of China.But adopt the medicine prior art of the way treatment prostatosis that improves human body testosterone levels, anti-inflammation, enhancing immunity and inducing diuresis for treating stranguria syndrome not see open.

The objective of the invention is, a kind of medicine that adopts the way treatment prostatosis that improves human body testosterone levels, anti-inflammation, enhancing immunity and inducing diuresis for treating stranguria syndrome is provided, particularly adopt the pharmacological property of Eurycoma longifolia and propolis to realize its goal of the invention.

The present invention realizes that the prescription that goal of the invention adopts is, Eurycoma longifolia, propolis, Radix Ginseng and Cortex Eucommiae medicine are formed.

Eurycoma longifolia, formal name used at school: Eurycoma longifolia Jack, Simarubaceae (Simarubaceae), English name: Ali ' s Umbrella, another name: in Malaysia ginseng, the leather Asia, east.Nature,taste and action: bitter in the mouth, cool in nature, heat clearing away, preventing the attack (or recurrence) of malaria, dampness removing jaundice eliminating, tonifying YANG, sending down the abnormal ascending QI the turbid descending, diuresis etc.Studies show that Eurycoma longifolia root (particularly core) comprises over one hundred kind of plant chemicalses such as yohimbine, collagen protein, antioxidant and bran unit saponin.

The mechanism of action of Eurycoma longifolia treatment prostatosis is:

(1) can promote the level of testosterone, reach as high as more than 400%, reach and strengthen and the effect of nourishing human body gonad function.Testosterone is the required hormone of male's sexual, also is that genitals and brain are grown required hormone.According to the report of a Straits Times week on May 1, in 999 periodical, assistant Harry of Univ Malaya not Harmer doctor Sha A points out that the feeding Eurycoma longifolia is got the male Mus behind the liquid, and sexual behaviour number of times active and female Mus copulation is more frequent.

(2) utilize its potent anti-inflammation composition, act on the gonad position of human body, effectively eliminate the focus at gonad position.

(3) blood circulation of reinforcement human body helps medicine to enter the gonad position, promotes the drug effect performance, makes the elimination of the various symptoms of prostate.

Propolis, the composition more complicated of propolis has identified more than 300 kind of chemical compound.Wherein flavone compound is 71 kinds, 95 kinds of aromatic acid and aromatic acid lipoid substances, 25 kinds in aminoacid, 17 kinds of aldehyde and ketone compounds, 50 kinds of fatty acid and fatty acid esters, 19 kinds of acid compounds, 6 kinds of steroidal compounds, 9 kinds of saccharide compounds, 25 kinds of hydrocarbon compounds, 34 kinds of alcohol, phenols and other chemical compounds.Also have multivitamin and more than 30 kind of constant and trace element etc.Propolis is the height concentrate of plants ' medicinal component, and more than its contained medicinal ingredient, the height of concentration is that medicinal plants can't be compared.Thereby has a multiple pharmacological effect.Immunological enhancement, propolis has effect widely to body immune system, has both strengthened humoral immune function, promotes cellular immune function again.Propolis can promote body to increase the antibody generation, can strengthen huge thin brain phagocytic activity and the natural killer cell activity bitten again, improves specificity and nonspecific immunologic function of body.Antioxidation, utilize oxygen be vital movement wait the most substantially levy.But in oxidizing process, can constantly produce active oxygen and free radical in the body, it is generally acknowledged that the skin aging that many senile disease, cancer, radiation injury, drug intoxication and ultraviolet cause all is associated with active oxygen and free radical.Propolis is the Natural antioxidant of generally acknowledging, it contains the material such as flavone compound, unsaturated fatty acid, vitamin E, vitamin C and trace element zinc, selenium of abundant antioxidation, thereby has significant antioxidant role.Studies have shown that propolis promptly has very strong oxidation resistance under 0.01%～0.05% concentration, and superoxide dismutase (SOD) activity is significantly improved.Antibacterial action contains a large amount of flavonoids, aromatic acid, fatty acid and terpene compound in the propolis, have broad-spectrum antibacterial action.

Radix Ginseng, warm in nature, sweet in the mouth, little hardship.Function cures mainly; Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves.Be used for that weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung are breathed with cough, Tianjin wound is thirsty.The main component that plays therapeutical effect in the Radix Ginseng is the ginsenoside.Show the root of Radix Ginseng, stem, leaf, the obvious anti-hypoxia of Hua Douyou, antifatigue effect through pharmacological testing.Flos Ginseng's nourishing and fit keeping function effect surpasses Radix Ginseng, but the Radix Ginseng enhancing body is strengthened the adaptability of body to the defence capability of destructive stimulus, and anti-stress effects such as obvious anti-fatigue, anti-hypoxia, anti-low temperature and antinoise are arranged.The Radix Ginseng anti-stress effect is relevant with the function of excited hypothalamus-hypophysis-interrenal system.

The Cortex Eucommiae, antibiotic, antiviral all contains chlorogenic acid in the Cortex Eucommiae, and chlorogenic acid has very strong antibacterial action, and the effect of class epinephrine is arranged.Peach jaurel aglycon and polymer thereof have tangible bacteriostasis.The peach jaurel aglycon all has inhibitory action to Gram-negative, positive bacteria.Aucubin has antibacterial, diuresis, and can promote the wound healing aucubin after glucosidase is cultivated in advance, also can produce tangible antivirus action, but itself does not have the antiviral function.Diuresis, the Cortex Eucommiae has diuresis, and does not have tachylaxis, and normal rat and mice are also had diuresis.The diuresis of the Cortex Eucommiae is relevant with aucubin, and this composition can stimulate the parasympathetic nervous pivot, accelerates uric acid and shifts and discharge, and diuresis is obvious.

Pharmaceutical formulation of the present invention is that it is the medicament of being made by the following weight parts proportion raw material:

Eurycoma longifolia 4-6, propolis 1-3, Radix Ginseng 1-2, Cortex Eucommiae 1-2.

The weight portion proportioning of each raw material of optimum formula is:

Eurycoma longifolia 5, propolis 2, Radix Ginseng 1.5, the Cortex Eucommiae 1.5.

The medicament of this said medicine is the above a dosage form of any pharmaceutics.

The beneficial effect of medicine of the present invention is that relaxing muscles and tendons and activating QI and blood in the collateral is tonified Qi of the kidney, and heightens the body immunity function with the mediator, anti-inflammation, diuresis promoting.

The toxicologic study conclusion

1, animal acute toxicity experiment research, adopt the maximum tolerance determination method that the safety of medicine animals administer of the present invention is estimated, observe the toxic reaction situation of the once heavy dose of administration of medicine of the present invention to laboratory animal, requirement according to the toxicology test observation, trial test grouping administration, 240 of male Mus, strong age, (9-12 month) high dose group was not seen death, therefore can't calculate the median lethal dose(LD 50) (LD50) of this dosage.

2, animal drug effect experimentation, 240 of male Mus, strong age, (9-12 month) divided two groups of contrasts, one group is experimental group, another group is matched group, experimental group is administered once by 80mg/1kg every day, amount to 30 days, the result shows, the male Mus of experimental group is to the activity of the female Mus of youth (smell anus lick straddle), and the genitality of self is modified and the restrained motion monarch in the specific region rises, but descends at the activity (climb and thirst for surveying) of external environment, voided volume increases by 440%, and the response speed ratio that male Mus is made correct selection obviously rises.

Through clinical preliminary observation, for prostate class disease, as patients such as soreness of the waist and knees, lassitude and weak, nocturia frequency, dysuria, the heeltaps, clinical observation 200 examples, effective percentage is more than 85%.None routine untoward reaction, safe and effective.

The specific embodiment

Eurycoma longifolia 4-6, propolis 1-3, Radix Ginseng 1-2, Cortex Eucommiae 1-2.

The weight portion proportioning of each raw material of optimum formula is:

Eurycoma longifolia 5, propolis 2, Radix Ginseng 1.5, the Cortex Eucommiae 1.5.

Claims

1. medicine for the treatment of prostatosis, it is characterized in that: it is the medicament of being made by the following weight parts proportion raw material:

Eurycoma longifolia 4-6 propolis 1-3 Radix Ginseng 1-2 Cortex Eucommiae 1-2.

2. a kind of medicine for the treatment of prostatosis according to claim 1 is characterized in that: wherein the weight portion proportioning of each raw material is:

Eurycoma longifolia 5 propolis 2 Radix Ginsengs 1.5 Cortexs Eucommiae 1.5.

3. a kind of medicine for the treatment of prostatosis according to claim 1 and 2 is characterized in that: described medicament is the above a dosage form of any pharmaceutics.