CN108651893A - The kidney-tonifying and yang-strengthening oral solution and preparation method thereof to skim the cream off milk with filefish - Google Patents

The kidney-tonifying and yang-strengthening oral solution and preparation method thereof to skim the cream off milk with filefish Download PDF

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Publication number
CN108651893A
CN108651893A CN201810481566.9A CN201810481566A CN108651893A CN 108651893 A CN108651893 A CN 108651893A CN 201810481566 A CN201810481566 A CN 201810481566A CN 108651893 A CN108651893 A CN 108651893A
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parts
filefish
weight
kidney
cream
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黄仕研
黄诗曼
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Dalian Jun Gate Health Food Co Ltd
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Dalian Jun Gate Health Food Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/65—Addition of, or treatment with, microorganisms or enzymes
    • A—HUMAN NECESSITIES
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
    • A23L21/25—Honey; Honey substitutes
    • A—HUMAN NECESSITIES
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    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Abstract

With the kidney-tonifying and yang-strengthening oral solution and preparation method thereof that filefish skims the cream off milk, it belongs to health nutrient oral solution field.The present invention is mainly made of the fresh filefish flesh of fish, Tongkat Ali, burdock, sealwort, prepared rehmannia root, Herba Cistanches, vitamin C, vitamin E, Schisandra chinensis nectar, pure water, parts by weight be respectively 500~1000 parts the fresh filefish flesh of fish, 100~400 parts of Tongkat Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, 10~50 parts of vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar, 10000~40000 parts of pure water.The present invention has effects that kidney-replenishing, benefiting essence-blood, has rehabilitation efficacy to male's dizziness insomnia, urine urgency-frequency, soreness and weakness of waist and knees, impotence and premature ejaculation.

Description

The kidney-tonifying and yang-strengthening oral solution and preparation method thereof to skim the cream off milk with filefish
Technical field
The invention belongs to health nutrient oral solution fields；More particularly to a kind of tonifying kidney and strengthening yang mouth to skim the cream off milk with filefish Take liquid and preparation method thereof.
Background technology
Chinese medicine thinks that the kidney being the origin of congenital constitution, built-in nephroyin and nephroyang, and kidney deficiency with pain in the back with based on aching and limp, rub by dizziness and tinnitus, happiness Happiness is pressed, and leg knee is powerless, meets labor more very, sleeping then mitigate, normal recurrent exerbation.If the substance usually consumed is relatively more, such as sexual life Excessively frequently or labour's (including mental, physical) excessively, or body of being born is on the weak side, and material base is weak, is susceptible to waist and knee Aching and limp, dysphoria in chestpalms-soles, limbs fatigue, dizziness and tinnitus, alopecia tooth pine, decrease of memory, sexual hypoesthesia, seminal emission, premature ejaculation etc. are The symptom of kidney deficiency.
Filefish meat quality of fish exquisiteness, delicious flavour, unsaturated fatty acid content is higher, and wherein Content of Eicosapentaenoic Acid is 15.36%, sour (EPA) content of 22 carbon six is 6-19%, and unsaturated fatty acid is the street cleaner of blood vessel, can prevent cholesterol It is deposited on vascular wall, prevents or mitigate artery sclerosis, prevent headstroke and myocardial infarction, enhance memory and thinking ability, Delay encephalatrophy, prevent senile dementia, improve the visual acuity of vision, and has significant beneficial brain, brain strengthening function.From Chinese medicine angle Analyze the filefish flesh of fish：Sweet in flavor, warm-natured, energy qi-restoratives, suitable apathetic, body is tired weak, palpitation, the diseases such as insomnia forgetfulness, energy Clearing damp gas：Suitable for do not feel like eating, sleepy, the soft stool of body weight, the diseases such as oliguria with yellow urine can improve waist foot：It is adapted to the soreness of waist back of the body Pain, the diseases such as soreness and weakness of waist and knees have effects that tonifying kidney and strengthening yang.But filefish carries the special circumstances of toxin because of body, needs to process Edible globe fish must should first remove internal organs before working process in conditional local concentrated processing, skin, first-class toxic portion Position, rinses muscle repeatedly, cleans blood stains, adds 2% sodium bicarbonate to handle 24 hours, can be sold after test sensitivity qualification, institute Simply daily fresh globe fish can not can be eaten.
Invention content
It is an object of the present invention to provide a kind of kidney-tonifying and yang-strengthening oral solutions and preparation method thereof to skim the cream off milk with filefish.
The invention is realized by the following technical scheme：
A kind of preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, includes the following steps：
Step 1, the fresh filefish flesh of fish for weighing 500~1000 parts respectively according to parts by weight, 100~400 parts of east leather Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, 10~50 The vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar of part；
Step 2, the load weighted fresh filefish fish powder of step 1 is broken, the pure water of 20~40 times of mass ratioes of addition, mixing After uniformly, the protease of mass percent 0.5~2% is added, is uniformly mixed, 5~8h is digested at 35~50 DEG C, is added after enzymolysis Heat 10~15min of inactivation, obtains enzymolysis liquid, for use；
Step 3, by load weighted Tongkat Ali root, burdock, sealwort, prepared rehmannia root, Herba Cistanches, be put into pulverizer and be crushed to Drug after crushing, is added the deionized water of 8~15 times of weight by 20~100 mesh, and the temperature of the deionized water is 70~ 80 DEG C, obtain mixed solution；
Step 4, by mixed solution made from step 3, be put into microwave abstracting machine and carry out microwave abstracting, be put into after extraction from It is centrifuged in centrifugal separator, the product after centrifugation is divided into supernatant and residue, and supernatant is poured into container and is preserved, will Residue after centrifugation is put into microwave abstracting machine and is extracted again, is centrifuged after extraction, and residue reprocesses 2 times, The supernatant obtained after processing is merged into container；
Step 5, the supernatant for obtaining step 4 are evaporated under reduced pressure, and vacuum distillation condition is pressure -100~-85kPa, depressurizes 30~35 DEG C of the temperature of distillation, 20~60min of time obtain concentrate, a concentration of soluble solid of the concentrate Content is mass fraction 35~40%, for use；
Step 6, vitamin C, the vitamin for weighing concentrate that enzymolysis liquid that step 2 obtains, step 5 obtain, step 1 E, Schisandra chinensis nectar is uniformly mixed under ultrasound condition, is filtered, ageing, and the benefit to skim the cream off milk with filefish is made in sterile filling Kidney and enhancing body oral solution.
The preparation method of the kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, described in step 1 The Fugu rubripes of filefish flesh of fish behaviour work cultivation or the fresh flesh of fish of fugu obscurus.
The preparation method of the kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish is added 30 in step 2 The protease of mass percent 1% is added after mixing in the pure water of times mass ratio, and the protease is pepsin, It is uniformly mixed, digests 6h at 45 DEG C, heat inactivation 12min after enzymolysis, heat inactivated temperature is 100 DEG C, obtains enzymolysis liquid.
The preparation method of the kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, microwave extracts in step 4 It is 60~300s of extraction time, 60~90 DEG C of extraction temperature, 2000~3000MHz of microwave frequency to take condition；Centrifugation condition For 3000~10000rpm of centrifuge speed, 5~30min of centrifugation time.
The preparation method of the kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish is depressurized in step 5 and is steamed It is pressure -100kPa, 30 DEG C of the temperature of vacuum distillation, time 30min to evaporate condition, and a concentration of solubility of the concentrate is solid Shape object content is mass fraction 40%.
The preparation method of the kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, step 6 ultrasound condition For 1000~2000W of ultrasonic power, 20~50kHz of supersonic frequency, 20~30min of ultrasonic time；Filter screen mesh number 100~200 Mesh；Aging condition is 0~5 DEG C, is aged 24~48h；Sterile filling capacity is 50ml/ bottles.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, described there is filefish to skim the cream off milk Kidney-tonifying and yang-strengthening oral solution is mainly by the fresh filefish flesh of fish, Tongkat Ali, burdock, sealwort, prepared rehmannia root, Herba Cistanches, vitamin C, dimension Raw element E, Schisandra chinensis nectar, pure water are made, parts by weight be respectively 500~1000 parts the fresh filefish flesh of fish, 100~ 400 parts of Tongkat Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of meat Desert cistanche, 10~50 parts of vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar, 10000~40000 parts Pure water.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, described there is filefish to skim the cream off milk The parts by weight of the fresh filefish flesh of fish are 500 parts in kidney-tonifying and yang-strengthening oral solution, the parts by weight of Tongkat Ali are 100 parts, burdock Parts by weight be 100 parts, the parts by weight of sealwort are 50 parts, the parts by weight of prepared rehmannia root are 50 parts, the parts by weight of Herba Cistanches Number is 50 parts, ascorbic parts by weight are 10 parts, the parts by weight of vitamin E are 10 parts, the parts by weight of Schisandra chinensis nectar Parts by weight for 0 part, pure water are 10000 parts.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, described there is filefish to skim the cream off milk The parts by weight of the fresh filefish flesh of fish are 1000 parts in kidney-tonifying and yang-strengthening oral solution, the parts by weight of Tongkat Ali are 400 parts, burdock Parts by weight be 400 parts, the parts by weight of sealwort are 70 parts, the parts by weight of prepared rehmannia root are 70 parts, the parts by weight of Herba Cistanches Number is 70 parts, ascorbic parts by weight are 50 parts, the parts by weight of vitamin E are 50 parts, the parts by weight of Schisandra chinensis nectar Parts by weight for 50 parts, pure water are 40000 parts.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, described there is filefish to skim the cream off milk The parts by weight of the fresh filefish flesh of fish are 700 parts in kidney-tonifying and yang-strengthening oral solution, the parts by weight of Tongkat Ali are 150 parts, burdock Parts by weight be 250 parts, the parts by weight of sealwort are 70 parts, the parts by weight of prepared rehmannia root are 70 parts, the parts by weight of Herba Cistanches Number is 70 parts, ascorbic parts by weight are 30 parts, the parts by weight of vitamin E are 30 parts, the parts by weight of Schisandra chinensis nectar Parts by weight for 20 parts, pure water are 20000 parts.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, the filefish flesh of fish：It is sweet in flavor, warm-natured, can mend Void, suitable apathetic, body is tired weak, palpitation, the diseases such as insomnia forgetfulness, can clearing damp gas：Suitable for do not feel like eating, body is stranded again Tired, soft stool, the diseases such as oliguria with yellow urine can improve waist foot：It is adapted to ache all over, the diseases such as soreness and weakness of waist and knees have tonifying kidney and strengthening yang The effect of.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, Tongkat Ali nickname Malaysia ginseng, east leather In Asia.Dicotyledoneae, Angiospermae, Simarubaceae, Sapindales, wild bush plant.It is more to be generally only distributed in the torrid zone In the moist sandy soil of rain country, source area Malaysia.Maturity period is generally 5 years or more.Set 4-6 meters high, trunk diameter 8- 10 centimetres, root enters most deep up to 2 meters.The root of Tongkat Ali is there are many effect, together with bird's nest, tinware and referred to as Ma Laixi Sub- three big national treasures.In Malaysia, Tongkat Ali has the title of Malaysia ginseng, is always taken as postnatal nourishing product, improves male's Sexuality, treatment diabetes, hypertension, prostatitis, pulmonary tuberculosis, fever, jaundice and dysentery.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish contains peroxidase in radix bardanae, It can enhance the vigor of cellular immune mechanism, remove internal oxygen radical, prevent the generation and accumulation of lipofuscin pigment in vivo, Anti-aging provides the interior retaining ring border of confrontation and scavenging activated oxygen for body.Arctiolid can inhibit phosphoric acid in cancer cell The activity of fructosyl enzyme, Arctigenin also has active anticancer, while arctigenin also has Anti-alzheimer's disease effect.Burdock Containing flavonoid compounds, there is certain resistance, crude extract can inhibit in selection toxicity, relatively low amount malignant tumour Cancer cell multiplication keeps tumour cell close to normal cell.Arctiin and arctigenin-4'-gentiobioside have anti-nephritic activity, can effectively treat urgency Property progressive ephritis and chronic glomerulus kidney, do treatment of kidney disease agent.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, sealwort also known as：Polygonatum sibiricum Redoute, yellow chicken Dish, pen tube dish, claw ginseng, tendrilleaf solomonseal rhizome, achickenclaw ginseng.For HUANGJING ZANYU CAPSULE, rhizome it is horizontal walk, cylindric, tubercle expands.Impeller generator, Stockless.There is medicinal plant tonifying spleen, the effect resisting pathogenic microbes of moistening lung and production of body fluid to act on：In vitro test shows, sealwort water proposes Liquid (1:320) there are inhibiting effect, 2% sealwort right in sabouraud culture medium typhoid bacillus, staphylococcus aureus, acid-fast bacilli Common causative fungi has different degrees of inhibiting effect, can be used as natural bacteriostatic agent, preservative.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, prepared rehmannia root tonifying kidney-yin, beneficial to spirit and marrow.It is main Control the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation collapses Leak down blood, dizziness and tinnitus, poliosis.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, Herba Cistanches kidney-replenishing；Benefiting essence-blood；Ease constipation Road.Main decline of kidney-YANG；The impotence of asthenia of essence and blood；Seminal emission；Gonorrhoea；The frequent micturition heeltap；Pain in the back flaccidity of lower limbs；Tinnitus mesh is spent；Menstruation is spread out the phase；Palace It is cold infertile；Dry constipation of intestines.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, Schisandra chinensis nectar category Chinese medicine honey kind are adopted From the Schisandra chinensis nectar of relieving diarrhea with astringents, color and luster is slightly deep, sweet tea sweet in flavor, slightly Chinese medicine fragrance.Schisandra honey, hundred it is wonderful appear, at home often It is standby, surely play the work(of accident.The honey includes schizandrin, citrate malate, vitamin A and C, therefore can control neural function Disease, scheroma and mouth disease, and can clearing away the liver-fire, the gas of tonifying five zang organs.Also there is removing toxic substances, only diarrhea, sterilization and astriction, it is right Double empty, the spleen kidney deficiency of lung kidney are trembled with fear, shortness of breath asthma is weary, the strongly fragrant lung of convulsive seizure due to phlegm-fire has good auxiliary therapeutic effect.It is particularly suitable for abnormal sweating, the deficiency syndrome of the lung, kidney deficiency, chronic diarrhea Protracted dysentery, hemorrhoid blood, daily Dietotherapy health of having blood in stool et al. are used.
Advantageous effect：
The preparation method of the kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, utilizes fresh globe fish Meat realizes breakthrough of the protein macromolecule to small molecule " peptide " using enzymatic isolation method, and secondary point is not necessarily to after so that nutriment is entered human body Solution can be by the quick simultaneously overall absorption of human body, the effect of having the function that efficiently to supplement, reach kidney-replenishing, benefiting essence-blood, to male's head Dizzy insomnia, urine urgency-frequency, soreness and weakness of waist and knees, impotence and premature ejaculation have rehabilitation efficacy.
The preparation method of the kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, using Tongkat Ali, Burdock, sealwort, prepared rehmannia root, Herba Cistanches using microwave-assisted extraction technique and be evaporated under reduced pressure concentration technique to mixing Chinese medicine in it is effective at Divide and extracted, have the advantages that extraction is quick, efficient, at low cost, microwave abstracting process is that frequency electromagnetic waves penetrate extraction Jie Matter reaches the inside vascular bundle and glandular cell's system of material.On the other hand, caused by microwave electromagnetic field acceleration be extracted part at Point to extractant interface diffusion rate, shorten the molecule of extracted component by be diffused into inside material extractant interface when Between, to make extraction rate improve several times, while extraction temperature is also reduced, ensures the quality of extraction to greatest extent, realize The effect of kidney-replenishing, benefiting essence-blood, has rehabilitation efficacy to male's dizziness insomnia, urine urgency-frequency, soreness and weakness of waist and knees, impotence and premature ejaculation.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish, progress acute toxicity test, sperm are abnormal Shape is tested, the results show that the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish is safe and non-toxic.
The kidney-tonifying and yang-strengthening oral solution of the present invention to skim the cream off milk with filefish can after 60 days after volunteer takes All improve dizzy insomnia, urine urgency-frequency improvement rate reaches 92.6%, and soreness and weakness of waist and knees rate reaches 93.4%, and impotence and premature ejaculation changes Kind rate reaches 87.8%, illustrates kidney-tonifying and yang-strengthening oral solution that the present invention skims the cream off milk with filefish with kidney-replenishing, benefiting essence-blood Effect has rehabilitation efficacy to male's dizziness insomnia, urine urgency-frequency, soreness and weakness of waist and knees, impotence and premature ejaculation.
Specific implementation mode
Specific implementation mode one：
A kind of preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, includes the following steps：
Step 1, the fresh filefish flesh of fish for weighing 500~1000 parts respectively according to parts by weight, 100~400 parts of east leather Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, 10~50 The vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar of part；
Step 2, the load weighted fresh filefish fish powder of step 1 is broken, the pure water of 20 times of mass ratioes of addition, it is uniformly mixed Afterwards, the protease of mass percent 0.5% is added, is uniformly mixed, digests 5h at 35 DEG C, heat inactivation 15min after enzymolysis is obtained To enzymolysis liquid, for use；
Step 3, by load weighted Tongkat Ali root, burdock, sealwort, prepared rehmannia root, Herba Cistanches, be put into pulverizer and be crushed to The deionized water of 8 times of weight is added in drug after crushing by 20 mesh, and the temperature of the deionized water is 70 DEG C, is mixed Solution；
Step 4, by mixed solution made from step 3, be put into microwave abstracting machine and carry out microwave abstracting, be put into after extraction from It is centrifuged in centrifugal separator, the product after centrifugation is divided into supernatant and residue, and supernatant is poured into container and is preserved, will Residue after centrifugation is put into microwave abstracting machine and is extracted again, is centrifuged after extraction, and residue reprocesses 2 times, The supernatant obtained after processing is merged into container；
Step 5, the supernatant for obtaining step 4 are evaporated under reduced pressure, and vacuum distillation condition is pressure -100kPa, is evaporated under reduced pressure 30 DEG C of temperature, time 20min, obtain concentrate, a concentration of soluble solid content of the concentrate is quality point Number 35%, for use；
Step 6, vitamin C, the vitamin for weighing concentrate that enzymolysis liquid that step 2 obtains, step 5 obtain, step 1 E, Schisandra chinensis nectar is uniformly mixed under ultrasound condition, is filtered, ageing, and the benefit to skim the cream off milk with filefish is made in sterile filling Kidney and enhancing body oral solution.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, institute in step 1 The Fugu rubripes for the filefish flesh of fish behaviour work cultivation stated or the fresh flesh of fish of fugu obscurus.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, enzyme in step 2 Heat inactivation 12min after solution, heat inactivated temperature are 100 DEG C, obtain enzymolysis liquid.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, it is micro- in step 4 Wave extraction conditions is extraction time 60s, 60 DEG C of extraction temperature, microwave frequency 2000MHz；Centrifugation condition is centrifuge speed 3000rpm, centrifugation time 10min.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, step 6 ultrasound Condition is ultrasonic power 1000W, supersonic frequency 20kHz, ultrasonic time 20min；100 mesh of filter screen mesh number；Aging condition is 0 DEG C, ageing is for 24 hours；Sterile filling capacity is 50ml/ bottles.
Specific implementation mode two：
The preparation method system of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode one The standby kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, the kidney-tonifying and yang-strengthening oral solution master to skim the cream off milk with filefish Will by the fresh filefish flesh of fish, Tongkat Ali, burdock, sealwort, prepared rehmannia root, Herba Cistanches, vitamin C, vitamin E, Schisandra chinensis nectar, Pure water is made, and the parts by weight of the fresh filefish flesh of fish are in the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish 500 parts, the parts by weight of Tongkat Ali be 100 parts, the parts by weight of burdock are 100 parts, the parts by weight of sealwort are 50 parts, ripe The parts by weight of glutinous rehmannia are 50 parts, the parts by weight of Herba Cistanches are 50 parts, ascorbic parts by weight are 10 parts, vitamin E Parts by weight are 10 parts, the parts by weight of Schisandra chinensis nectar are 0 part, the parts by weight of pure water are 10000 parts.
Prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment has The kidney-tonifying and yang-strengthening oral solution that filefish skims the cream off milk carries out Drug toxicity trails：
Rat acute toxicity test：Using maximum tolerated dose method, the tonifying kidney and strengthening yang that will be skimmed the cream off milk with filefish Oral solution is contaminated with 10 each to male and female rat (180-220g) oral gavages of 10.0ml/kg body weight doses.By 10ml/kg bodies The secondary gavage of weight is given, and 4h is spaced.After contamination, general status, poisoning symptom and the death condition of rat are observed, observes the time limit two Week.Test result：Sample is all higher than 10.0ml/kg weight to the maximum tolerated dose of the acute oral of male and female mouse.
Chmice acute Oral toxicity is tested：Using maximum tolerated dose method, the tonifying kidney and strengthening yang that will be skimmed the cream off milk with filefish Oral solution is contaminated with 10 each to male and female mouse (18-22g) oral gavages of 10.0ml/kg body weight doses.By 10ml/kg weight Secondary gavage is given, and 4h is spaced.After contamination, general status, poisoning symptom and the death condition of mouse are observed, observes the time limit two Week.Test result：Sample is all higher than 10.0ml/kg weight to the maximum tolerated dose of the acute oral of male and female mouse.
Mouse inbred strain：By the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish for doing experimental group, separately set Negative control (distilled water) and positive controls (mitomycin C 2.0mg/kg weight), every group of 10 male mices (25-30g). By 10ml/kg weight, respectively to each group animal gavage.Once a day, continuous 5 days.The 35th day after giving sample for the first time, two side pairs are taken Testis shreds, and takes filtrate film-making.Microscopy is observed, and the lopsided number of 1000 sperms is counted per mouse.Sample sperm malformation test result is cloudy Property.
Prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment has The kidney-tonifying and yang-strengthening oral solution that filefish skims the cream off milk carries out above-mentioned acute toxicity test, sperm malformation test, the results show that described The kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish it is safe and non-toxic.
Specific implementation mode three：
A kind of preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, includes the following steps：
Step 1, the fresh filefish flesh of fish for weighing 500~1000 parts respectively according to parts by weight, 100~400 parts of east leather Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, 10~50 The vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar of part；
Step 2, the load weighted fresh filefish fish powder of step 1 is broken, the pure water of 40 times of mass ratioes of addition, it is uniformly mixed Afterwards, the protease of mass percent 2% is added, is uniformly mixed, digests 6h at 50 DEG C, heat inactivation 15min after enzymolysis is obtained Enzymolysis liquid, for use；
Step 3, by load weighted Tongkat Ali root, burdock, sealwort, prepared rehmannia root, Herba Cistanches, be put into pulverizer and be crushed to The deionized water of 15 times of weight is added in drug after crushing by 100 mesh, and the temperature of the deionized water is 80 DEG C, is mixed Close solution；
Step 4, by mixed solution made from step 3, be put into microwave abstracting machine and carry out microwave abstracting, be put into after extraction from It is centrifuged in centrifugal separator, the product after centrifugation is divided into supernatant and residue, and supernatant is poured into container and is preserved, will Residue after centrifugation is put into microwave abstracting machine and is extracted again, is centrifuged after extraction, and residue reprocesses 2 times, The supernatant obtained after processing is merged into container；
Step 5, the supernatant for obtaining step 4 are evaporated under reduced pressure, and vacuum distillation condition is pressure -85kPa, is evaporated under reduced pressure 35 DEG C of temperature, time 60min obtain concentrate, and a concentration of soluble solid content of the concentrate is mass fraction 40%, for use；
Step 6, vitamin C, the vitamin for weighing concentrate that enzymolysis liquid that step 2 obtains, step 5 obtain, step 1 E, Schisandra chinensis nectar is uniformly mixed under ultrasound condition, is filtered, ageing, and the benefit to skim the cream off milk with filefish is made in sterile filling Kidney and enhancing body oral solution.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, institute in step 1 The Fugu rubripes for the filefish flesh of fish behaviour work cultivation stated or the fresh flesh of fish of fugu obscurus.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, enzyme in step 2 Heat inactivation 12min after solution, heat inactivated temperature are 100 DEG C, obtain enzymolysis liquid.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, it is micro- in step 4 Wave extraction conditions is extraction time 300s, 90 DEG C of extraction temperature, microwave frequency 3000MHz；Centrifugation condition is centrifugal basket Fast 10000rpm, centrifugation time 15min.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, step 6 ultrasound Condition is ultrasonic power 2000W, supersonic frequency 50kHz, ultrasonic time 30min；200 mesh of filter screen mesh number；Aging condition is 5 DEG C, ageing is for 24 hours；Sterile filling capacity is 50ml/ bottles.
Specific implementation mode four：
The preparation method system of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode three The standby kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, the kidney-tonifying and yang-strengthening oral solution master to skim the cream off milk with filefish Will by the fresh filefish flesh of fish, Tongkat Ali, burdock, sealwort, prepared rehmannia root, Herba Cistanches, vitamin C, vitamin E, Schisandra chinensis nectar, Pure water is made, and the parts by weight of the fresh filefish flesh of fish are in the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish 1000 parts, the parts by weight of Tongkat Ali be 400 parts, the parts by weight of burdock are 400 parts, the parts by weight of sealwort are 70 parts, The parts by weight of prepared rehmannia root are 70 parts, the parts by weight of Herba Cistanches are 70 parts, ascorbic parts by weight are 50 parts, vitamin E Parts by weight be 50 parts, the parts by weight of Schisandra chinensis nectar are 50 parts, the parts by weight of pure water are 40000 parts.
Prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment has The kidney-tonifying and yang-strengthening oral solution that filefish skims the cream off milk carries out stability test test：The tonifying kidney and strengthening yang that will be skimmed the cream off milk with filefish Oral solution respectively takes three batches of samples by commercially available back through being placed 3 months at 37~40 DEG C of temperature and 75% relative humidities, in 0 The moon, January, 2 months, March carry out all events detections (including organoleptic indicator, identification, total ash, disintegration to the three batches of samples respectively Time limit, acid value, peroxide value, lead arsenic mercury, six six six, DDT, net content minus deviation, total plate count, coliform, mould, Saccharomycete, salmonella, Shigella, golden yellow Portugal coccus, hemolytic), testing result meets this product quality mark Accurate regulation.
Prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment has The kidney-tonifying and yang-strengthening oral solution that filefish skims the cream off milk carries out male rat mating ability test：The benefit that will be skimmed the cream off milk with filefish The grouping of kidney and enhancing body oral solution is tested, and test dose 1ml/kg, Adult male rats orally continuously give sample 30 days, control Group awards the distilled water of 1ml/kg, after the last administration, male rat list is only put into cage and adapts it to environment 30min, then It is put into 1 female mice, start recording：It is put into from female mice and flutters the time (capture incubation period) for catching female mice for the first time to male mouse, in 30min Male mouse flutters the number for catching female mice, flutters in 30min and to catch flutterring for number of animals and catch percentage record the results are shown in Table 1, from female mice Put into male mouse for the first time the time (ejaculation latency) of ejaculation, male mouse ejaculation frequency in 30min, ejaculation to occur in 30min dynamic The results are shown in Table 2 for the ejaculation percentage record of object number：
1 male rat mating ability of table captures the test table of comparisons
* the P compared with blank group<0.05
2 male rat mating ability of the table ejaculation test table of comparisons
* the P compared with blank group<0.01
It can be, it is evident that the capture of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish be latent from Tables 1 and 2 Phase captures number, percentage significant difference (P compared with the control group<0.05) Bu Shen Zhuang, to skim the cream off milk with filefish The ejaculation latency of positive oral solution, ejaculation frequency, percentage significant difference (P compared with the control group<0.05).
Specific implementation mode five：
A kind of preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, includes the following steps：
Step 1, the fresh filefish flesh of fish for weighing 500~1000 parts respectively according to parts by weight, 100~400 parts of east leather Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, 10~50 The vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar of part；
Step 2, the load weighted fresh filefish fish powder of step 1 is broken, the pure water of 20~40 times of mass ratioes of addition, mixing After uniformly, the protease of mass percent 1% is added, is uniformly mixed, digests 6h at 450 DEG C, heat inactivation after enzymolysis 15min obtains enzymolysis liquid, for use；
Step 3, by load weighted Tongkat Ali root, burdock, sealwort, prepared rehmannia root, Herba Cistanches, be put into pulverizer and be crushed to The deionized water of 10 times of weight is added in drug after crushing by 100 mesh, and the temperature of the deionized water is 80 DEG C, is mixed Close solution；
Step 4, by mixed solution made from step 3, be put into microwave abstracting machine and carry out microwave abstracting, be put into after extraction from It is centrifuged in centrifugal separator, the product after centrifugation is divided into supernatant and residue, and supernatant is poured into container and is preserved, will Residue after centrifugation is put into microwave abstracting machine and is extracted again, is centrifuged after extraction, and residue reprocesses 2 times, The supernatant obtained after processing is merged into container；
Step 5, the supernatant for obtaining step 4 are evaporated under reduced pressure, and vacuum distillation condition is pressure -100kPa, is evaporated under reduced pressure 35 DEG C of temperature, time 30min, obtain concentrate, a concentration of soluble solid content of the concentrate is quality point Number 40%, for use；
Step 6, vitamin C, the vitamin for weighing concentrate that enzymolysis liquid that step 2 obtains, step 5 obtain, step 1 E, Schisandra chinensis nectar is uniformly mixed under ultrasound condition, is filtered, ageing, and the benefit to skim the cream off milk with filefish is made in sterile filling Kidney and enhancing body oral solution.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, institute in step 1 The Fugu rubripes for the filefish flesh of fish behaviour work cultivation stated or the fresh flesh of fish of fugu obscurus.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, step 2 enzymolysis Heat inactivation 12min afterwards, heat inactivated temperature are 100 DEG C, obtain enzymolysis liquid.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, it is micro- in step 4 Wave extraction conditions is extraction time 200s, 90 DEG C of extraction temperature, microwave frequency 3000MHz；Centrifugation condition is centrifugal basket Fast 10000rpm, centrifugation time 15min.
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, step 6 ultrasound Condition is ultrasonic power 2000W, supersonic frequency 50kHz, ultrasonic time 20min；100 mesh of filter screen mesh number；Aging condition is 1 DEG C, it is aged 48h；Sterile filling capacity is 50ml/ bottles.
Specific implementation mode six：
The preparation method system of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode five The standby kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, the kidney-tonifying and yang-strengthening oral solution master to skim the cream off milk with filefish Will by the fresh filefish flesh of fish, Tongkat Ali, burdock, sealwort, prepared rehmannia root, Herba Cistanches, vitamin C, vitamin E, Schisandra chinensis nectar, Pure water is made, and the parts by weight of the fresh filefish flesh of fish are in the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish 700 parts, the parts by weight of Tongkat Ali be 150 parts, the parts by weight of burdock are 250 parts, the parts by weight of sealwort are 70 parts, ripe The parts by weight of glutinous rehmannia are 70 parts, the parts by weight of Herba Cistanches are 70 parts, ascorbic parts by weight are 30 parts, vitamin E Parts by weight are 30 parts, the parts by weight of Schisandra chinensis nectar are 20 parts, the parts by weight of pure water are 20000 parts.
Prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment has The kidney-tonifying and yang-strengthening oral solution that filefish skims the cream off milk, 100 male volunteers are taken, and 100 volunteer's ages are at 40-60 Sui Between, average age 44.7 years old takes 50ml daily, take it is front and back carry out existing symptom and carry out number record, take 15 days, Number record is carried out after 30 days, 60 days, comparison is as shown in table 3：
Table 3 takes semiograhy contrast table (people)
, it can be seen that taking the aspiration for the kidney-tonifying and yang-strengthening oral solution that present embodiment skims the cream off milk with filefish from table 3 Person can all improve dizzy insomnia after 60 days, urine urgency-frequency improvement rate reaches 92.6%, and soreness and weakness of waist and knees rate reaches 93.4%, impotence and premature ejaculation improvement rate reaches 87.8%, illustrates that the tonifying kidney and strengthening yang that there is present embodiment filefish to skim the cream off milk is oral Liquid has effects that kidney-replenishing, benefiting essence-blood, is imitated with rehabilitation to male's dizziness insomnia, urine urgency-frequency, soreness and weakness of waist and knees, impotence and premature ejaculation Fruit.
Specific implementation mode seven：
A kind of preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, includes the following steps：
Step 1, the fresh filefish flesh of fish for weighing 500~1000 parts respectively according to parts by weight, 100~400 parts of east leather Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, 10~50 The vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar of part；
Step 2, the load weighted fresh filefish fish powder of step 1 is broken, the pure water of 20~40 times of mass ratioes of addition, mixing After uniformly, the protease of mass percent 0.5~2% is added, is uniformly mixed, 5~8h is digested at 35~50 DEG C, is added after enzymolysis Heat 10~15min of inactivation, obtains enzymolysis liquid, for use；
Step 3, by load weighted Tongkat Ali root, burdock, sealwort, prepared rehmannia root, Herba Cistanches, be put into pulverizer and be crushed to Drug after crushing, is added the deionized water of 8~15 times of weight by 20~100 mesh, and the temperature of the deionized water is 70~ 80 DEG C, obtain mixed solution；
Step 4, by mixed solution made from step 3, be put into microwave abstracting machine and carry out microwave abstracting, be put into after extraction from It is centrifuged in centrifugal separator, the product after centrifugation is divided into supernatant and residue, and supernatant is poured into container and is preserved, will Residue after centrifugation is put into microwave abstracting machine and is extracted again, is centrifuged after extraction, and residue reprocesses 2 times, The supernatant obtained after processing is merged into container；
Step 5, the supernatant for obtaining step 4 are evaporated under reduced pressure, and vacuum distillation condition is pressure -100~-85kPa, depressurizes 30~35 DEG C of the temperature of distillation, 20~60min of time obtain concentrate, a concentration of soluble solid of the concentrate Content is mass fraction 35~40%, for use；
Step 6, vitamin C, the vitamin for weighing concentrate that enzymolysis liquid that step 2 obtains, step 5 obtain, step 1 E, Schisandra chinensis nectar is uniformly mixed under ultrasound condition, is filtered, ageing, and the benefit to skim the cream off milk with filefish is made in sterile filling Kidney and enhancing body oral solution.
Specific implementation mode eight：
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode seven, step The Fugu rubripes of filefish flesh of fish behaviour work cultivation described in rapid 1 or the fresh flesh of fish of fugu obscurus.
Specific implementation mode nine：
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode seven, step The pure water of 30 times of mass ratioes is added in rapid 2, after mixing, the protease of mass percent 1%, the protease is added It for pepsin, being uniformly mixed, digests 6h at 45 DEG C, heat inactivation 12min after enzymolysis, heat inactivated temperature is 100 DEG C, Obtain enzymolysis liquid.
Specific implementation mode ten：
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode seven, step Microwave abstracting condition is 60~300s of extraction time, 60~90 DEG C of extraction temperature, 2000~3000MHz of microwave frequency in rapid 4；From Heart separation condition is 3000~10000rpm of centrifuge speed, 5~30min of centrifugation time.
Specific implementation mode 11：
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode seven, step In rapid 5 be evaporated under reduced pressure condition be pressure -100kPa, 30 DEG C of the temperature of vacuum distillation, time 30min, the concentrate it is dense It is mass fraction 40% that degree, which is soluble solid content,.
Specific implementation mode 12：
The preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode seven, step Rapid 6 ultrasound condition is 1000~2000W of ultrasonic power, 20~50kHz of supersonic frequency, 20~30min of ultrasonic time；Filter mesh 100~200 mesh of number；Aging condition is 0~5 DEG C, is aged 24~48h；Sterile filling capacity is 50ml/ bottles.
Specific implementation mode 13：
The preparation method system of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish according to specific implementation mode seven The standby kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, the kidney-tonifying and yang-strengthening oral solution master to skim the cream off milk with filefish Will by the fresh filefish flesh of fish, Tongkat Ali, burdock, sealwort, prepared rehmannia root, Herba Cistanches, vitamin C, vitamin E, Schisandra chinensis nectar, Pure water is made, parts by weight be respectively 500~1000 parts the fresh filefish flesh of fish, 100~400 parts of Tongkat Ali, 100 ~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, the life of 10~50 parts of dimension Plain C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar, 10000~40000 parts of pure water.
The kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, carries out acute toxicity test, essence Sub- deformity experiment, the results show that the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish is safe and non-toxic.
The kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in present embodiment, after volunteer takes, after 60 days Dizzy insomnia can all be improved, urine urgency-frequency improvement rate reaches 92.6%, and soreness and weakness of waist and knees rate reaches 93.4%, and impotence is early Let out improvement rate and reach 87.8%, illustrate kidney-tonifying and yang-strengthening oral solution that present embodiment skims the cream off milk with filefish with kidney-replenishing, The effect of benefiting essence-blood, has rehabilitation efficacy to male's dizziness insomnia, urine urgency-frequency, soreness and weakness of waist and knees, impotence and premature ejaculation.

Claims (10)

1. a kind of preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, it is characterised in that：Include the following steps：
Step 1, the fresh filefish flesh of fish for weighing 500~1000 parts respectively according to parts by weight, 100~400 parts of Tongkat Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, 10~50 parts Vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar；
Step 2, the load weighted fresh filefish fish powder of step 1 is broken, the pure water of 20~40 times of mass ratioes of addition, it is uniformly mixed Afterwards, the protease of mass percent 0.5~2% is added, is uniformly mixed, 5~8h is digested at 35~50 DEG C, heats and goes out after enzymolysis 10~15min living, obtains enzymolysis liquid, for use；
Step 3, by load weighted Tongkat Ali root, burdock, sealwort, prepared rehmannia root, Herba Cistanches, be put into pulverizer and be crushed to 20~ The deionized water of 8~15 times of weight is added in drug after crushing by 100 mesh, and the temperature of the deionized water is 70~80 DEG C, Obtain mixed solution；
Step 4, by mixed solution made from step 3, be put into microwave abstracting machine and carry out microwave abstracting, be put into after extraction centrifugation point It is centrifuged in disembarking, the product after centrifugation is divided into supernatant and residue, and supernatant is poured into container and is preserved, and will centrifuge Residue afterwards is put into microwave abstracting machine and is extracted again, is centrifuged after extraction, and residue reprocesses 2 times, will locate The supernatant obtained after reason is merged into container；
Step 5, the supernatant for obtaining step 4 are evaporated under reduced pressure, and vacuum distillation condition is pressure -100~-85kPa, is evaporated under reduced pressure 30~35 DEG C of temperature, 20~60min of time, obtain concentrate, a concentration of soluble solid content of the concentrate For mass fraction 35~40%, for use；
Step 6, the vitamin C that concentrate that enzymolysis liquid that step 2 obtains, step 5 obtain, step 1 are weighed, vitamin E, five Taste nectar is uniformly mixed under ultrasound condition, is filtered, ageing, and the Bu Shen Zhuang to skim the cream off milk with filefish is made in sterile filling Positive oral solution.
2. the preparation method of the kidney-tonifying and yang-strengthening oral solution according to claim 1 to skim the cream off milk with filefish, feature exist In：The Fugu rubripes of filefish flesh of fish behaviour work cultivation described in step 1 or the fresh flesh of fish of fugu obscurus.
3. the preparation method of the kidney-tonifying and yang-strengthening oral solution according to claim 1 to skim the cream off milk with filefish, feature exist In：The pure water of 30 times of mass ratioes is added in step 2, after mixing, the protease of mass percent 1% is added, it is described Protease is pepsin, is uniformly mixed, digests 6h at 45 DEG C, heat inactivation 12min after enzymolysis, and heat inactivated temperature is 100 DEG C, obtain enzymolysis liquid.
4. the preparation method of the kidney-tonifying and yang-strengthening oral solution according to claim 1 to skim the cream off milk with filefish, feature exist In：In step 4 microwave abstracting condition be 60~300s of extraction time, 60~90 DEG C of extraction temperature, microwave frequency 2000~ 3000MHz；Centrifugation condition is 3000~10000rpm of centrifuge speed, 5~30min of centrifugation time.
5. the preparation method of the kidney-tonifying and yang-strengthening oral solution according to claim 1 to skim the cream off milk with filefish, feature exist In：It is pressure -100kPa, 30 DEG C of the temperature of vacuum distillation, time 30min, the concentrate that condition is evaporated under reduced pressure in step 5 A concentration of soluble solid content be mass fraction 40%.
6. the preparation method of the kidney-tonifying and yang-strengthening oral solution according to claim 1 to skim the cream off milk with filefish, feature exist In：Step 6 ultrasound condition is 1000~2000W of ultrasonic power, 20~50kHz of supersonic frequency, 20~30min of ultrasonic time；It crosses 100~200 mesh of strainer mesh number；Aging condition is 0~5 DEG C, is aged 24~48h；Sterile filling capacity is 50ml/ bottles.
7. prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish described in a kind of one of claim 1-6 The kidney-tonifying and yang-strengthening oral solution to skim the cream off milk with filefish, it is characterised in that：The Bu Shen Zhuang to skim the cream off milk with filefish Positive oral solution mainly by the fresh filefish flesh of fish, Tongkat Ali, burdock, sealwort, prepared rehmannia root, Herba Cistanches, vitamin C, vitamin E, Schisandra chinensis nectar, pure water are made, parts by weight be respectively 500~1000 parts the fresh filefish flesh of fish, 100~400 parts Tongkat Ali, 100~400 parts of burdock, 50~70 parts of sealwort, 50~70 parts of prepared rehmannia root, 50~70 parts of Herba Cistanches, 10 ~50 parts of vitamin C, 10~50 parts of vitamin E, 0~50 part of Schisandra chinensis nectar, 10000~40000 parts of pure water.
8. prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution according to claim 7 to skim the cream off milk with filefish has The kidney-tonifying and yang-strengthening oral solution that filefish skims the cream off milk, it is characterised in that：The tonifying kidney and strengthening yang to skim the cream off milk with filefish is oral The parts by weight of the fresh filefish flesh of fish are 500 parts in liquid, the parts by weight of Tongkat Ali are 100 parts, the parts by weight of burdock are 100 parts, the parts by weight of sealwort be 50 parts, the parts by weight of prepared rehmannia root are 50 parts, the parts by weight of Herba Cistanches are 50 parts, dimension life The parts by weight of plain C are 10 parts, the parts by weight of vitamin E are 10 parts, the parts by weight of Schisandra chinensis nectar are 0 part, pure water Parts by weight be 10000 parts.
9. prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution according to claim 7 to skim the cream off milk with filefish has The kidney-tonifying and yang-strengthening oral solution that filefish skims the cream off milk, it is characterised in that：The tonifying kidney and strengthening yang to skim the cream off milk with filefish is oral The parts by weight of the fresh filefish flesh of fish are 1000 parts in liquid, the parts by weight of Tongkat Ali are 400 parts, the parts by weight of burdock are 400 parts, the parts by weight of sealwort be 70 parts, the parts by weight of prepared rehmannia root are 70 parts, the parts by weight of Herba Cistanches are 70 parts, dimension life The parts by weight of plain C are 50 parts, the parts by weight of vitamin E are 50 parts, the parts by weight of Schisandra chinensis nectar are 50 parts, pure water Parts by weight be 40000 parts.
10. tool prepared by the preparation method of the kidney-tonifying and yang-strengthening oral solution according to claim 7 to skim the cream off milk with filefish There is the kidney-tonifying and yang-strengthening oral solution that filefish skims the cream off milk, it is characterised in that：The tonifying kidney and strengthening yang mouth to skim the cream off milk with filefish The parts by weight for taking the fresh filefish flesh of fish in liquid are 700 parts, the parts by weight of Tongkat Ali are 150 parts, the parts by weight of burdock Parts by weight for 250 parts, sealwort are 70 parts, the parts by weight of prepared rehmannia root are 70 parts, the parts by weight of Herba Cistanches are 70 parts, dimension The parts by weight of raw element C are 30 parts, the parts by weight of vitamin E are 30 parts, the parts by weight of Schisandra chinensis nectar are 20 parts, pure The parts by weight of water are 20000 parts.
CN201810481566.9A 2018-05-18 2018-05-18 The kidney-tonifying and yang-strengthening oral solution and preparation method thereof to skim the cream off milk with filefish Pending CN108651893A (en)

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