CN109043527A - It adjusts human-body sub-health and improves the composition and preparation process of immunity - Google Patents
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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Abstract
The present invention relates to adjust human-body sub-health and improve the composition and preparation process of immunity.The present composition is using the composition for made of composition made of the deer products and ocean fish oligopeptide powder, pueraria root powder, rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae etc. such as venison, deer's sinew, deer's tail, deer whip, deer kidney, the especially auxiliary materials such as addition xylitol being in pressed candy form.The present composition can be used as health care product, health food, health drink or medical product and use.The present composition has the effect of excellent enhancing human body kidney qi and improves renal function.In addition, the present composition also has the effect of excellent adjusting human-body sub-health and improves immunity.
Description
Technical field
The invention belongs to health-oriented products fields, are related to a kind of Chinese medicine composition with enhancing human body kidney qi and renal function,
And the purposes of the composition.Composition of the invention, which can be used as health care product, health food, health drink or medical product, to be made
With.In particular, using the deer product such as venison, deer's sinew, deer's tail, deer whip, deer kidney and ocean fish oligopeptide the present invention relates to a kind of
Made of composition made of powder, pueraria root powder, rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae etc., the especially auxiliary materials such as addition xylitol
In the composition of pressed candy form.In the present invention, the composition of the pressed candy form be also referred to as deer whip deer kidney piece or
Person is also referred to as deer whip deer kidney piece pressed candy.It adjusts human-body sub-health in addition, composition of the present invention also has and mentions
The function of high immunity;It is well known that and said from theory of traditional Chinese medical science angle, human body sub-health status and its immunity have tightly
Close inner link, immunity reduction then will appear various inferior health problems.
Background technique
Cervidae (Cervidae) is Mammalia artiodactylous animals.Body sizes etc. are angular ruminant, are distributed in Europe
Sub- continent, Japan, Philippine, Indonesia, North America, South America 40 ° of northern areas of south latitude and Southwest Africa, the whole world
There are about 34 kinds, totally 16 belong to about 52 kinds.Animal in deer family is it is characterized in that there is the angle of solid bifurcated, and generally only male has pair of horns,
Female is acerous, and body is 0.75~2.90 meter, 9~800 kilograms of weight long.
Since ancient times, deer starts after development is to the promotion of human health from the Shiqi meat of beginning, its skin of getting into bed, with its bone
The understanding that deepens continuously of phase.It has passed through the quite very long time." female refined " cloud: deer is celestial beast, the happy property of self energy, capable then have saliva, no
It whips again.It can be seen that ancients think that eating dried vension plays the role of promoting longevity, and is known as long shou " celestial deer.Famous Lee physician of the Ming Dynasty
Shi Zhen is mentioned in Compendium of Material Medica: " all beneficial people of the whole body of deer, or boil or steam or dried meat, with the good of food and drink.On the whole deer is celestial beast,
The object in pure sun more longevity can lead to governor vessel, and eat good grass, therefore its meat, angle only do good, not harm ".One famous herbal medicine " day of five generation of China
Magnificent son book on Chinese herbal medicine " in record: deer, qi-restoratives is thin, strengthens the bone, broken stasis of blood blood, gas under miscarriage prevention.It can be seen that people treat men and women's reproduction disease to Smilacina japonica
Disease is early recognized.Deer not only greatly prolongs the reproduction time limit of male, but also the right for being mother is grant again and returns that
It is a little thirst for being mother and cannot all living things, outstanding contribution has been made to the procreation of the mankind, has been worshipped it is that reason is worked as by people
Right.So deer is from ancient times just to have been assigned healthy symbolic meaning.Deer is a kind of favorite wild mammal of people, is belonged to
Ruminant.Share forties kinds of deer in the world, China just has more than 20 kinds, be distributed it is very wide, but be distributed it is most be Xinjiang, it is interior
The ground such as illiteracy, northeast.The mainly precious sika deer to live in forest around Jingpo Lake.Jingpo Lake forest zone, The surrounding mountains are like the billows of the sea, toothed oak tree
It grows into forest, has sufficient water source and rich forage grass, be natural pasture.Other than wild deer, some forest farms, farm, rural area have
Deer farm.Sika deer is that a kind of posture is delicate and pretty, and the animal of meek in spirit, whole body has bright-coloured bronzing undercoat, body two sides
White dot as being covered with plum blossom.It is about 70 kilograms of doe weight or so, high 90 centimeters or so, acerous;Stag weight about one
120 kilograms or so, high one meter or so, symmetrical long angle as branch is had on head.Deer is timid easily frightened, runs and is exceedingly fast, people
Claim " flying on grass ".Just there is saying for " deer body hundred being precious " in China from ancient times, and the main purpose for supporting deer is to take pilose antler.Pilose antler is rare medicine
Material, it and ginseng, fur are known as " northeast Triratna ".Long angle is the secondary sex characters of stag.Stag after birth the 13rd to
Between 14 months, start long angle;Annual three, start to take off the cutin floral disc of aging April, then gradually a pair of tender angle of protuberance, it is this
Unossified angle is famous pilose antler.Pilose antler is made of fine and soft root, trunk and several side shoots.Its crust has one layer of fibre
Fine hair is tieed up, as velvety good shield;Inside is connective, cartilaginous tissue, has blood vessel and mind distribution, is flesh pink, also has apricot yellow
Color, as the beautiful coral of cluster crystal jade-like stone.Every year since Clear and Bright, by two months or so time, first planting young pilose antler can be sawed
Angle.Antler under saw is over-cooked fried processing, is exactly valuable pilose antler.Pilose antler has more than 2,000 years in China as medicinal
History.The function that medicine secretary carries, and pilose antler has " nourishing yin and nourishing blood mends able-bodied sun ".It is proved by medical practice, pilose antler is rich in
Protein ties up its life, calcium, magnesium, hormone etc., it has mends marrow of promoting the production of body fluid, the effectiveness of benefiting qi and supporting yang;It can promote human development.It can also
Treat thin and weak, dark, gynaecological disease of mesh of internal lesion caused by overexertion etc..Manufactured pantocrine, the complex containing a large amount of hormone and phosphorus, can treat the heart
The illnesss such as popular name for, low blood pressure, chornic arthritis, serious suppuration wound.In addition, deer blood, deer horn, the deer heart, deer's sinew, deer's tail, deer whip,
Deer kidney, deer tire have very high medical value, are all the treasures of nourishing and fit keeping function.Venison contains high protein and low fat, is advanced
Food: deerskin also manufactures high leather.The whole body of deer is all treasured, and economic value is high.
Kidney is a kind of organ of vertebrate, belongs to a part of urinary system, impurity, maintenance in responsible filtering blood
The balance of body fluid and electrolyte finally generates urine per urethra and excretes;Has endocrine function also simultaneously to adjust blood
Pressure.In human body, normal adult has two pieces of kidneys, is located at waist two sides rear.Distinctive enzyme is glycerokinase, phosphorus in kidney
Sour enolpyruvate carboxylic kinases, they are highly important enzymes.It normally says, kidney is the total valve of human body body fluid system.With
Micro- sem observation, it is seen that the nephron and a small amount of knot that each kidney mainly has identical structure and function by about 1,000,000
It forms tissue to be formed, there is a large amount of blood vessels and nerve fibre therebetween.The nephron is made of Malpighian corpuscle and renal tubule two parts.Renal tubule
Converge again into concetrated pipe.Kidney is located at waist, backbone both sides, left and right each one, therefore " Plain Questions arteries and veins will be through micro- opinion " is said: " waist person, kidney it
Mansion ".Since kidney keeps " congenital essence ", originally for internal organs yin-yang, Source of life, therefore kidney is referred to as " the congenital foundation ".Kidney is in the five-element
Belong to water.Since the kidney channel of foot-Shaoyin and the mutual network of the urinary bladder channel of foot-Taiyang belong to kidney and bladder, therefore kidney is with bladder that forming an integral part.Kidney has
The powerful ability for needing to adjust water excretion according to body, to maintain the stabilization of body fluid pervious concentration.The water filtered out from glomerulus
Point nearly 80% in proximal tubule and medullary loop descending branch by reabsorption.The reabsorption of this part water and the reabsorption of solute are related, and sodium is certainly
Tubule Cavity surface is absorbed as passively, it is adjoint to exchange with hydrogen ion, and glucose, amino acid and phosphatic absorption are then with disperse
Form enters cell, and has Na+, K+-ATP enzyme in cell basolateral membrane, sodium pump is actively entered intercellular fluid, to keep intracellular sodium
Balance.Kidney occurs mainly in concetrated pipe to the dilution concentration of urine.It is dense by countercurrent multiplication after filtrate enters medullary loop
Contracting.From cortex to medullary substance, the osmotic concentration of interstitial fluid gradually rises kidney, arrives highest at nephridial papilla.Each section of permeability of medullary loop
Difference, medullary loop descending branch readily penetrate through water, and urea is more difficult, and sodium chloride then can seldom permeate, therefore moisture is constantly to saturating between tissue
Out, sodium chloride concentration constantly increases in lumen;And ascending thin limb of Henle's loop then has height permeability to sodium ion, has moderate to urea
Permeability, but water is then not easy to penetrate.Therefore in ascending branch lumen, na concn is gradually decreased, and urea concentration then has raising.Always
It adjusts the position of human body water and osmotic balance mainly in renal tubule, and only in renal function slump of disastrous proportions, filtration rate extremely subtracts
When few, glomerulus can also influence the excretion of water.There are many factor for influencing kidney dilution concentration function, such as antidiuretic hormone, chronic renal
Insufficiency, diuretics etc..In short, kidney is to adjust body fluid by excretion metabolism waste, endocrine hormone is secreted, to maintain
Ambient stable in vivo, is normally carried out metabolism.To maintain normal excretory function, renal blood flow is generally kept in constant
In range, glomerular filtration rate about 120mL/min.Kidney has itself regulatory function, living by pipe ball feedback, renal nerve and blood vessel
Property the links such as substance adjust renal plasma flow, maintain glomerular filtration rate in a certain range.Glomerular filtration rate is by hair
The carefully influence of the permeability coefficient of intravascular pressure, renal plasma flow, arterial blood albumin concentration and filtration membrane, works as hypopiesia, kidney
Plasmaflux is reduced, and when plasma colloid osmotic pressure increases or permeability coefficient declines, glomerular filtration rate significantly reduces or stops.
Glomerular filtration membrane has barrier action to macromolecular substances, and the barrier of filtration membrane consists of two parts: first is that mechanical barrier,
With on filtration membrane pore size and configuration it is related;Second is that electrostatic barrier, glomerular filtration membrane is negatively charged, can be negative with preventing belt
The albumin of charge filters out.Under certain pathological states, the negative electrical charge on filtration membrane disappears, and makes a large amount of albumin through filtering membrane filtration
Out, albuminuria is formed.Urea, creatine, creatinine are main nitrogenous metabolite, are drained by glomerular filtration, and hippuric acid, benzene first
The organic acids such as sour and various amines then pass through tubular excretion.Mainly pass through renal cells to the endocrine way of lumen
Diameter carrys out excretion metabolism waste, based on the excretion of renal tubule proximal end, in addition to draining organic acid, is also discharged many into intracorporal medicine
Object, such as also proximally renal tubule is discharged for gentamicin, cephalosporin.Excretion is last in body substance metabolism overall process
A link is most basic one of the vital movement of body.The basic physiological function of kidney is to generate urine, is discharged from urine various
The water-soluble substances for needing to eliminate.On the one hand the movable physiological significance of kidney uropoiesis is the end for draining above-mentioned various metabolism
Product and entrance intracorporal drug and foreign matter etc.;On the one hand the discharge of the capacity and its ingredient of regulation body fluid again, retains body fluid
In the various nutriments useful to body and important electrolyte, such as sodium, potassium, bicarbonate and chloride ion were discharged
More water and electrolyte, especially hydrogen ion.Since the substance classes being discharged from kidney are most, quantity is very big, and can be with
The different situations of body and change urine volume and urine in substance discharge rate, adjust body water and osmotic balance, electrolyte
It plays an important role in acid-base balance.Therefore, kidney has been no longer regarded as simple excretory organs, but body inner ring
The very important component part of border regulating system.In addition, kidney can also generate a variety of biologically active substances, that is, have one concurrently
A little endocrine functions, such as generate hematopoietin, feritin, prostaglandin and the vitamine D3 of high activity etc., it can play
The effects of adjusting blood pressure, promoting RBC acceptor garland rate and adjust alcium and phosphor metabolization.Therefore kidney is to maintain human life and normal function institute
Required vitals.
Kidney is one of human five internal organs, in bladder phase table.Main store essential substances hides congenital essence and acquired essence, main development, life
Long, reproduction.Kidney, one of the five internal organs.Kidney is located at human body waist, left and right each one, including the gate of vitality.It is the congenital foundation, built-in kidney yang, member
It is sun, kidney-Yang and kidney yin, Kidney-Yin, Kidney-Yin, it is the dirty of store essential substances." six section state of internal organs opinion of Plain Questions ": " the main bruising of kidney person, the dominator of storing essence, essence
Place." Shen controls bone, the raw marrow of bone.And the brain being the reservoir of the marrow, so kidney essense is sufficient, naturally energetic, the state of mind is quick, hypermnesia,
It enjoys excellent health, takes action spry and light." Plain Questions ancient times innocence opinion ": " the kidney dominating water metabolism is hidden it by the essence of five ZANG-organs and six FU-organs." also referred to as
The congenital foundation.Kidney is source under water, and main water adjusts fluid metabolism with internal organs such as lung, spleen, three cokes, bladders jointly, is fluid metabolism
Important organ." Plain Questions is inverse to adjust opinion ": " kidney person's water is dirty, main body fluid." connect lung, main gas of receiving on kidney arteries and veins." difficult through four hardly possiblies ":
" respiratory function is concerned with the heart and lung sucks kidney and liver." and main bone, marrow is given birth to, brain is passed through, is had one's ideas straightened out in ear and two yin, it outside should be in waist." Plain Questions impotence
By ": " the kidney being in charge of bone and marrow." " Ling Shu Miraculous Pivot or Divine Axis vessles length ": " kidney-QI connecting with ear and can then hear the five notes of traditional Chinese music at kidney." " Plain Questions arteries and veins wants precise and tiny
By ": " waist person, house of kidney." because have one's ideas straightened out two yin due to department stool and urine.Post hiding fire from the gater of life again, be Kidney-Yin, Yuanyang it is dirty, therefore have " water
Fire it is dirty ", the title of " residence of yin-yang ".2. pulse study noun.Refer to the kidney channel of foot-Shaoyin." Ling Shu Miraculous Pivot or Divine Axis sheet is defeated ": " kidney goes out spring ..., and foot is few
Yin channel." 3. pulse study noun.Refer to the critical pulse condition of kidney." the flat popularity of Plain Questions is as opinion ": " kidney is shown in that penta is in heaven, is to call critical pulse condition being revealed all
Extremely." toponymy of 4. massaging.See kidney channel item.In " the wonderful hole in Shen controls bone origin road is very after piece " volume: " kidney person, the viscus with functions of reproduction and development, skill go out
Here, essence place.Its Hua Fa, fills in marrow.Kidney has two pieces, and a left side is kidney storing will, and the happy right side Shou ﹔ spirit Nei of will is life store essential substances.
Kidney person, negative gas, for the root of the five internal organs, the marrow and tooth of main body, tooth person bone originally, has after saying bone ".
Taoism is thought through interior refining, and after keeping vital essence sufficient, not only Kidney-Yin, Yuanyang can mutually help mutual root, and kidney water can be with
Rising is mutually helped with internal heat.In this way, the illnesss such as palpitation and insomnia, spermatorrhea caused by due to breakdown of the normal physiological coordination between the heart and the kidney, so that it may be improved, Er Qiexin
The function of coordinating internal organs can also be reinforced therewith.The abundance of Kidney-Yin also often appears as in mouth in refining function and generates a large amount of body fluid, this
Kind mouth saliva can irrigate internal organs, and skin of moistening is swallowed without spitting, then kidney water fills prosperous, and color is not withered.It is enough fall fire nourishing heart.
For Chinese medicine to the understanding of kidney, it is extensive that intension than modern medicine dissects its " kidney ".It considers that kidney human body be one extremely
Internal organs that are important and forgiving multiple functions;Built-in nephroyin and nephroyang (nickname of the yin-yang of kidney), be extreme misery residence, be it is congenital it
This, the root of life.Kidney and bladder, marrow, brain, hair, ear, two yin of Chinese medicine etc. constitute system.Chinese medicine thinks, kidney be it is congenital it
This, nephroyin and nephroyang of residing: the congenital foundation refers to that people founds root of body, " people begins to give birth to, first at essence ", and kidney storing essence, therefore the kidney being the origin of congenital constitution.
Kidney-Yin refers to that negative essence, Yuanyang refer to vigour, and nephroyin and nephroyang is in the vital movement of people --- it is formed into development from breeding and grew
Decisive role is played in journey.Kidney storing essence, main growth and development: kidney controlling essence storage is to use with gas, is related to the growth and development of people.Kidney
Arrogant decline is directly related to the overall process of the growth and development or even aging of people, is also related to the fecundity of people.Kidney is on the five colors
Belong to black, on the five tastes be it is salty, five upper to belong to the north, all sees in facial diagnosis in bladder phase table, therefore after nephrotic's illness
The foundation that therefore can be used as Chinese medical discrimination in black, is internal organs in table with bladder, therefore the disease of kidney, the disease of bladder are mutual
Dialectical analysis treatment.
In the entire life process, the prosperity and decline just because of essence in kidney changes, and birth, long, strong, old, is presented
Different physiological status.For people since childhood, kidney essense gradually fills Sheng.Person between twenty and fifty are arrived, kidney essense further fills Sheng, or even reaches pole
Point, body is sturdy, enjoys excellent health.And until old, kidney essense decline, body also gradually aging, the movement of whole body muscles and bones is not flexible, and tooth shakes
Hair is de-, show it is senile as.It draws an analogy, if kidney is the same as the tree root set greatly, and root is deep if people is a big tree
Can be full of leaves, kidney good body is better as a same reason.To in dysplasia clinical treatment, kidney tonifying be critical treatment method it
One;Kidney tonifying, essence replenishing is the important means for delaying senescence and treating geriatric disease again.The main Physiological Function of kidney has: 1. storage essences
Gas is human body reproduction, hematopoiesis, growth and development, the basic substance for defending disease and evil;2. body fluid metabolism is balanced, with bladder cooperation
Draining urine;3. being responsible for receiving gas, coordinate respiratory movement;4. the raw marrow of main bone, supports brain intelligence development;5. promoting natural on-off cycles of hair growth;6. kidney qi is logical
Ear controls hearing;7. the folding of two yin of control.
Those skilled in the art expect have new method to be used to enhance human body kidney qi and renal function, and provide for the method
Chinese medicine composition and its preparation process.Those skilled in the art are desirable to new method for adjusting human-body sub-health and mentioning
High immunity, and the Chinese medicine composition and its preparation process that provide for the method.
Summary of the invention
The purpose of the present invention is to provide a kind of new methods for enhancing human body kidney qi and renal function, and of the invention is another
Purpose is to provide a kind of Chinese medicine composition for the method, and another object of the present invention is to Chinese medicine compositions thus to provide its system
Standby technique.It has been unexpectedly discovered that the method for the present invention and composition can effectively realize the object of the invention and can
Obtain the effect of one or more aspects.It is accomplished the present invention is based on this discovery.In addition, similarly, of the invention is another
The new method of one kind is designed to provide for adjusting human-body sub-health and improving immunity.
For this purpose, first aspect present invention provides a kind of composition, be made of the following components: deer whip, deer kidney, deer's sinew,
Deer's tail, venison, ocean fish oligopeptide powder, pueraria root powder, rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae.
According to the present invention, wherein the composition can be used as health care product, health food, health drink or medical product.
Composition according to a first aspect of the present invention, is made of the following components: 5 parts by weight of deer whip, 1~3 weight of deer kidney
Part, 2~4 parts by weight of deer's sinew, 4~6 parts by weight of deer's tail, 7~9 parts by weight of venison, 4~6 parts by weight of ocean fish oligopeptide powder, maca
4~6 parts by weight of powder, 6~8 parts by weight of rhizoma polygonati, 7~9 parts by weight of Chinese yam, 7~9 parts by weight of raspberry, 7~9 parts by weight of fructus alpiniae oxyphyllae.
Composition according to a first aspect of the present invention, is made of the following components: 5 parts by weight of deer whip, deer kidney 1.5~2.5
Parts by weight, 2.5~3.5 parts by weight of deer's sinew, 4.5~5.5 parts by weight of deer's tail, 7.5~8.5 parts by weight of venison, ocean fish oligopeptide
4.5~5.5 parts by weight of powder, 4.5~5.5 parts by weight of pueraria root powder, 6.5~7.5 parts by weight of rhizoma polygonati, 7.5~8.5 parts by weight of Chinese yam,
7.5~8.5 parts by weight of raspberry, 7.5~8.5 parts by weight of fructus alpiniae oxyphyllae.
Composition according to a first aspect of the present invention, is made of the following components: 5 parts by weight of deer whip, 2 parts by weight of deer kidney,
3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 parts by weight of venison, 5 parts by weight of ocean fish oligopeptide powder, 5 parts by weight of pueraria root powder, rhizoma polygonati 7
Parts by weight, 8 parts by weight of Chinese yam, 8 parts by weight of raspberry, 8 parts by weight of fructus alpiniae oxyphyllae.
Composition according to a first aspect of the present invention, wherein also including pharmaceutic adjuvant.
Composition according to a first aspect of the present invention, wherein also including xylitol.In one embodiment, with every 5 weight
Part deer whip meter is measured, the additive amount of xylitol is 20~25 parts by weight, for example, 21~23 parts by weight, for example, 22 parts by weight.
Composition according to a first aspect of the present invention, wherein also including magnesium stearate.In one embodiment, with every 5
Parts by weight deer whip meter, the additive amount of magnesium stearate are 1~3 parts by weight, for example, 1.5~2.5 parts by weight, for example, 2 parts by weight.
Composition according to a first aspect of the present invention, wherein also including maltodextrin.In one embodiment, with every 5
Parts by weight deer whip meter, the additive amount of maltodextrin are 6~8 parts by weight, for example, 6.5~7.5 parts by weight, for example, 7 parts by weight.
Composition according to a first aspect of the present invention, wherein also including cornstarch.In one embodiment, with every 5
Parts by weight deer whip meter, the additive amount of cornstarch are 4~6 parts by weight, for example, 4.5~5.5 parts by weight, for example, 5 parts by weight.
Composition according to a first aspect of the present invention is made of following component: 5 parts by weight of deer whip, 1~3 weight of deer kidney
Part, 2~4 parts by weight of deer's sinew, 4~6 parts by weight of deer's tail, 7~9 parts by weight of venison, 4~6 parts by weight of ocean fish oligopeptide powder, maca
4~6 parts by weight of powder, 6~8 parts by weight of rhizoma polygonati, 7~9 parts by weight of Chinese yam, 7~9 parts by weight of raspberry, 7~9 parts by weight of fructus alpiniae oxyphyllae,
20~25 parts by weight of xylitol, 1~3 parts by weight of magnesium stearate, 6~8 parts by weight of maltodextrin, 4~6 parts by weight of cornstarch.
Composition according to a first aspect of the present invention is made of following component: 5 parts by weight of deer whip, deer kidney 1.5~2.5
Parts by weight, 2.5~3.5 parts by weight of deer's sinew, 4.5~5.5 parts by weight of deer's tail, 7.5~8.5 parts by weight of venison, ocean fish oligopeptide
4.5~5.5 parts by weight of powder, 4.5~5.5 parts by weight of pueraria root powder, 6.5~7.5 parts by weight of rhizoma polygonati, 7.5~8.5 parts by weight of Chinese yam,
7.5~8.5 parts by weight of raspberry, 7.5~8.5 parts by weight of fructus alpiniae oxyphyllae, 21~23 parts by weight of xylitol, magnesium stearate 1.5~2.5
Parts by weight, 6.5~7.5 parts by weight of maltodextrin, 4.5~5.5 parts by weight of cornstarch.
Composition according to a first aspect of the present invention is made of following component: 5 parts by weight of deer whip, 2 parts by weight of deer kidney,
3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 parts by weight of venison, 5 parts by weight of ocean fish oligopeptide powder, 5 parts by weight of pueraria root powder, rhizoma polygonati 7
Parts by weight, 8 parts by weight of Chinese yam, 8 parts by weight of raspberry, 8 parts by weight of fructus alpiniae oxyphyllae, 22 parts by weight of xylitol, 2 weight of magnesium stearate
Part, 7 parts by weight of maltodextrin, 5 parts by weight of cornstarch.
Composition according to a first aspect of the present invention is prepared by the method included the following steps:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added (3~7 times of water
Amount, such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as
It is dried under reduced pressure), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) ocean fish oligopeptide powder, pueraria root powder and optional pharmaceutic adjuvant (example are added in rapid gained fine powder one step up
If these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders), it is uniformly mixed, i.e.,
?.
Composition according to a first aspect of the present invention is the composition in tablet form, and it is by including as follows
What the method for step was prepared:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added (3~7 times of water
Amount, such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as
It is dried under reduced pressure), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, corn are added in rapid gained fine powder one step up
Starch (such as these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders), mixing
Uniformly;
(3) gained mixed material pelletized (for example, by using dry granulation), whole grain, magnesium stearate be added, mixed, tabletting.
Composition according to a first aspect of the present invention, wherein also including calcium phosphate.In one embodiment, with every 5 weight
Part deer whip meter is measured, the additive amount of calcium phosphate is 3~7 parts by weight, for example, 4~6 parts by weight, for example, 5 parts by weight.
Composition according to a first aspect of the present invention, wherein the calcium phosphate is after being pre-mixed with ocean fish oligopeptide powder
It is added in the composition.It has been unexpectedly discovered that marine fish is low when the present composition is prepared into tablet
Poly- Gly-His-Lys have adverse effect to the friability of tablet, and reason is that the friability of the tablet when not adding ocean fish oligopeptide powder refers to
It is marked in conventional tablet prescribed limit, and friability index is unacceptable when adding ocean fish oligopeptide powder;But in Jiang Hai
After foreign fish oligopeptide powder and calcium phosphate premix, it was thus unexpectedly found that the friability of tablet can be significantly improved;And it sends out
Existing, no matter whether adding silicified microcrystalline cellulose in tablet, calcium phosphate can effectively improve tablet friability performance.
Composition according to a first aspect of the present invention, wherein also including silicified microcrystalline cellulose.In one embodiment,
In terms of every 5 parts by weight deer whip, the additive amount of silicified microcrystalline cellulose is 2~5 parts by weight, for example, 3~4 parts by weight, for example,
3.5 parts by weight.
Composition according to a first aspect of the present invention, wherein the silicified microcrystalline cellulose is to prepare composition addition Ma
The stage of coffee is added in the composition.It has been unexpectedly discovered that adding a small amount of silication in the compositions of the present invention
Microcrystalline cellulose can significantly reduce the hygroscopicity of tablet;No matter and it has been found that whether adding calcium phosphate, silication in tablet
The hygroscopicity of tablet can be effectively reduced in microcrystalline cellulose.
Further, second aspect of the present invention, which provides, prepares composition and for example prepares any implementation of first aspect present invention
The method of composition described in scheme comprising following steps:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added (3~7 times of water
Amount, such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as
It is dried under reduced pressure), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) ocean fish oligopeptide powder, pueraria root powder and optional pharmaceutic adjuvant (example are added in rapid gained fine powder one step up
If these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders), it is uniformly mixed, i.e.,
?.
Method according to a second aspect of the present invention, the composition are the compositions in tablet form, and including as follows
Step:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added (3~7 times of water
Amount, such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as
It is dried under reduced pressure), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, corn are added in rapid gained fine powder one step up
Starch (such as these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders), mixing
Uniformly;
(3) gained mixed material pelletized (for example, by using dry granulation), whole grain, magnesium stearate be added, mixed, tabletting.
Method according to a second aspect of the present invention, the composition are made of the following components: 5 parts by weight of deer whip, deer kidney 1~
3 parts by weight, 2~4 parts by weight of deer's sinew, 4~6 parts by weight of deer's tail, 7~9 parts by weight of venison, 4~6 weight of ocean fish oligopeptide powder
Part, 4~6 parts by weight of pueraria root powder, 6~8 parts by weight of rhizoma polygonati, 7~9 parts by weight of Chinese yam, 7~9 parts by weight of raspberry, fructus alpiniae oxyphyllae 7~9
Parts by weight.
Method according to a second aspect of the present invention, the composition are made of the following components: 5 parts by weight of deer whip, deer kidney 1.5
~2.5 parts by weight, 2.5~3.5 parts by weight of deer's sinew, 4.5~5.5 parts by weight of deer's tail, 7.5~8.5 parts by weight of venison, marine fish are low
Poly- 4.5~5.5 parts by weight of Gly-His-Lys, 4.5~5.5 parts by weight of pueraria root powder, 6.5~7.5 parts by weight of rhizoma polygonati, 7.5~8.5 weight of Chinese yam
Part, 7.5~8.5 parts by weight of raspberry, 7.5~8.5 parts by weight of fructus alpiniae oxyphyllae.
Method according to a second aspect of the present invention, the composition are made of the following components: 5 parts by weight of deer whip, 2 weight of deer kidney
Measure part, 3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 parts by weight of venison, 5 parts by weight of ocean fish oligopeptide powder, 5 parts by weight of pueraria root powder,
7 parts by weight of rhizoma polygonati, 8 parts by weight of Chinese yam, 8 parts by weight of raspberry, 8 parts by weight of fructus alpiniae oxyphyllae.
Method according to a second aspect of the present invention also includes pharmaceutic adjuvant in the composition.
Method according to a second aspect of the present invention also includes xylitol in the composition.In one embodiment, with
Every 5 parts by weight deer whip meter, the additive amount of xylitol are 20~25 parts by weight, for example, 21~23 parts by weight, for example, 22 weight
Part.
Method according to a second aspect of the present invention also includes magnesium stearate in the composition.In one embodiment,
In terms of every 5 parts by weight deer whip, the additive amount of magnesium stearate is 1~3 parts by weight, for example, 1.5~2.5 parts by weight, for example, 2 weights
Measure part.
Method according to a second aspect of the present invention also includes maltodextrin in the composition.In one embodiment,
In terms of every 5 parts by weight deer whip, the additive amount of maltodextrin is 6~8 parts by weight, for example, 6.5~7.5 parts by weight, for example, 7 weights
Measure part.
Method according to a second aspect of the present invention also includes cornstarch in the composition.In one embodiment,
In terms of every 5 parts by weight deer whip, the additive amount of cornstarch is 4~6 parts by weight, for example, 4.5~5.5 parts by weight, for example, 5 weights
Measure part.
Method according to a second aspect of the present invention, the composition are made of the following components: 5 parts by weight of deer whip, deer kidney 1~
3 parts by weight, 2~4 parts by weight of deer's sinew, 4~6 parts by weight of deer's tail, 7~9 parts by weight of venison, 4~6 weight of ocean fish oligopeptide powder
Part, 4~6 parts by weight of pueraria root powder, 6~8 parts by weight of rhizoma polygonati, 7~9 parts by weight of Chinese yam, 7~9 parts by weight of raspberry, fructus alpiniae oxyphyllae 7~9
Parts by weight, 20~25 parts by weight of xylitol, 1~3 parts by weight of magnesium stearate, 6~8 parts by weight of maltodextrin, cornstarch 4~6
Parts by weight.
Method according to a second aspect of the present invention, the composition are made of the following components: 5 parts by weight of deer whip, deer kidney 1.5
~2.5 parts by weight, 2.5~3.5 parts by weight of deer's sinew, 4.5~5.5 parts by weight of deer's tail, 7.5~8.5 parts by weight of venison, marine fish are low
Poly- 4.5~5.5 parts by weight of Gly-His-Lys, 4.5~5.5 parts by weight of pueraria root powder, 6.5~7.5 parts by weight of rhizoma polygonati, 7.5~8.5 weight of Chinese yam
Part, 7.5~8.5 parts by weight of raspberry, 7.5~8.5 parts by weight of fructus alpiniae oxyphyllae, 21~23 parts by weight of xylitol, magnesium stearate 1.5~
2.5 parts by weight, 6.5~7.5 parts by weight of maltodextrin, 4.5~5.5 parts by weight of cornstarch.
Method according to a second aspect of the present invention, the composition are made of the following components: 5 parts by weight of deer whip, 2 weight of deer kidney
Measure part, 3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 parts by weight of venison, 5 parts by weight of ocean fish oligopeptide powder, 5 parts by weight of pueraria root powder,
7 parts by weight of rhizoma polygonati, 8 parts by weight of Chinese yam, 8 parts by weight of raspberry, 8 parts by weight of fructus alpiniae oxyphyllae, 22 parts by weight of xylitol, magnesium stearate 2
Parts by weight, 7 parts by weight of maltodextrin, 5 parts by weight of cornstarch.
Method according to a second aspect of the present invention also includes calcium phosphate in the composition.In one embodiment, with
Every 5 parts by weight deer whip meter, the additive amount of calcium phosphate are 3~7 parts by weight, for example, 4~6 parts by weight, for example, 5 parts by weight.
Method according to a second aspect of the present invention, wherein the calcium phosphate is added after being pre-mixed with ocean fish oligopeptide powder
It is added in the composition.
Method according to a second aspect of the present invention also includes silicified microcrystalline cellulose in the composition.Implement at one
In scheme, in terms of every 5 parts by weight deer whip, the additive amount of silicified microcrystalline cellulose is 2~5 parts by weight, for example, 3~4 parts by weight,
For example, 3.5 parts by weight.
Method according to a second aspect of the present invention, wherein the silicified microcrystalline cellulose is to prepare composition addition maca
Stage be added in the composition.
Further, third aspect present invention provides the method for enhancing human body kidney qi and renal function, and this method includes giving
Subject in need applies composition;Or third aspect present invention provides composition in preparation for enhancing human body kidney qi
And the purposes in the product of renal function.In one embodiment, the product be health care product, health food, health drink or
Medical product.
Alternatively, further, third aspect present invention provides the method for improving human body energy and adjusting equilibrium between yin and yang,
This method includes applying composition to subject in need;Or third aspect present invention provides composition and is used in preparation
Improve the purposes in the product of human body energy and adjusting equilibrium between yin and yang.Or third aspect present invention provides composition and is making
It is ready for use on the purposes for adjusting human-body sub-health and improving in immunity and antifatigue product.In one embodiment, institute
Stating product is health care product, health food, health drink or medical product.
Method or purposes according to a third aspect of the present invention, wherein the composition is made of the following components: deer whip, deer
Kidney, deer's sinew, deer's tail, venison, ocean fish oligopeptide powder, pueraria root powder, rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae.For example, the combination
Object is made of the following components: 5 parts by weight of deer whip, 3 parts by weight of deer kidney, 2 parts by weight of deer's sinew, 6 parts by weight of deer's tail, 7 parts by weight of venison,
6 parts by weight of ocean fish oligopeptide powder, 4 parts by weight of pueraria root powder, 8 parts by weight of rhizoma polygonati, 7 parts by weight of Chinese yam, 9 parts by weight of raspberry, benefit
7 parts by weight of intelligence benevolence.
Method or purposes according to a third aspect of the present invention, wherein the composition can be used as health care product, health care food
Product, health drink or medical product.
Method or purposes according to a third aspect of the present invention, wherein the composition is made of the following components: 5 weight of deer whip
Measure part, 1~3 parts by weight of deer kidney, 2~4 parts by weight of deer's sinew, 4~6 parts by weight of deer's tail, 7~9 parts by weight of venison, ocean fish oligopeptide
4~6 parts by weight of powder, 4~6 parts by weight of pueraria root powder, 6~8 parts by weight of rhizoma polygonati, 7~9 parts by weight of Chinese yam, 7~9 parts by weight of raspberry,
7~9 parts by weight of fructus alpiniae oxyphyllae.
Method or purposes according to a third aspect of the present invention, wherein the composition is made of the following components: 5 weight of deer whip
Measure part, 1.5~2.5 parts by weight of deer kidney, 2.5~3.5 parts by weight of deer's sinew, 4.5~5.5 parts by weight of deer's tail, 7.5~8.5 weight of venison
Measure part, 4.5~5.5 parts by weight of ocean fish oligopeptide powder, 4.5~5.5 parts by weight of pueraria root powder, 6.5~7.5 parts by weight of rhizoma polygonati, mountain
7.5~8.5 parts by weight of medicine, 7.5~8.5 parts by weight of raspberry, 7.5~8.5 parts by weight of fructus alpiniae oxyphyllae.
Method or purposes according to a third aspect of the present invention, wherein the composition is made of the following components: 5 weight of deer whip
Measure part, 2 parts by weight of deer kidney, 3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 parts by weight of venison, 5 parts by weight of ocean fish oligopeptide powder, Ma
5 parts by weight of coffee powder, 7 parts by weight of rhizoma polygonati, 8 parts by weight of Chinese yam, 8 parts by weight of raspberry, 8 parts by weight of fructus alpiniae oxyphyllae.
Method or purposes according to a third aspect of the present invention, wherein also including pharmaceutic adjuvant in the composition.
Method or purposes according to a third aspect of the present invention, wherein also including xylitol in the composition.At one
In embodiment, in terms of every 5 parts by weight deer whip, the additive amount of xylitol is 20~25 parts by weight, for example, 21~23 parts by weight,
For example, 22 parts by weight.
Method or purposes according to a third aspect of the present invention, wherein also including magnesium stearate in the composition.One
In a embodiment, in terms of every 5 parts by weight deer whip, the additive amount of magnesium stearate is 1~3 parts by weight, for example, 1.5~2.5 weights
Measure part, for example, 2 parts by weight.
Method or purposes according to a third aspect of the present invention, wherein also including maltodextrin in the composition.One
In a embodiment, in terms of every 5 parts by weight deer whip, the additive amount of maltodextrin is 6~8 parts by weight, for example, 6.5~7.5 weights
Measure part, for example, 7 parts by weight.
Method or purposes according to a third aspect of the present invention, wherein also including cornstarch in the composition.One
In a embodiment, in terms of every 5 parts by weight deer whip, the additive amount of cornstarch is 4~6 parts by weight, for example, 4.5~5.5 weights
Measure part, for example, 5 parts by weight.
Method or purposes according to a third aspect of the present invention, wherein the composition is made of following component: 5 weight of deer whip
Measure part, 1~3 parts by weight of deer kidney, 2~4 parts by weight of deer's sinew, 4~6 parts by weight of deer's tail, 7~9 parts by weight of venison, ocean fish oligopeptide
4~6 parts by weight of powder, 4~6 parts by weight of pueraria root powder, 6~8 parts by weight of rhizoma polygonati, 7~9 parts by weight of Chinese yam, 7~9 parts by weight of raspberry,
7~9 parts by weight of fructus alpiniae oxyphyllae, 20~25 parts by weight of xylitol, 1~3 parts by weight of magnesium stearate, 6~8 parts by weight of maltodextrin, jade
4~6 parts by weight of rice starch.
Method or purposes according to a third aspect of the present invention, wherein the composition is made of following component: 5 weight of deer whip
Measure part, 1.5~2.5 parts by weight of deer kidney, 2.5~3.5 parts by weight of deer's sinew, 4.5~5.5 parts by weight of deer's tail, 7.5~8.5 weight of venison
Measure part, 4.5~5.5 parts by weight of ocean fish oligopeptide powder, 4.5~5.5 parts by weight of pueraria root powder, 6.5~7.5 parts by weight of rhizoma polygonati, mountain
7.5~8.5 parts by weight of medicine, 7.5~8.5 parts by weight of raspberry, 7.5~8.5 parts by weight of fructus alpiniae oxyphyllae, 21~23 weight of xylitol
Part, 1.5~2.5 parts by weight of magnesium stearate, 6.5~7.5 parts by weight of maltodextrin, 4.5~5.5 parts by weight of cornstarch.
Method or purposes according to a third aspect of the present invention, wherein the composition is made of following component: 5 weight of deer whip
Measure part, 2 parts by weight of deer kidney, 3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 parts by weight of venison, 5 parts by weight of ocean fish oligopeptide powder, Ma
5 parts by weight of coffee powder, 7 parts by weight of rhizoma polygonati, 8 parts by weight of Chinese yam, 8 parts by weight of raspberry, 8 parts by weight of fructus alpiniae oxyphyllae, 22 weight of xylitol
Part, 2 parts by weight of magnesium stearate, 7 parts by weight of maltodextrin, 5 parts by weight of cornstarch.
Method or purposes according to a third aspect of the present invention, wherein the composition is the method by including the following steps
It is prepared:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added (3~7 times of water
Amount, such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as
It is dried under reduced pressure), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) ocean fish oligopeptide powder, pueraria root powder and optional pharmaceutic adjuvant (example are added in rapid gained fine powder one step up
If these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders), it is uniformly mixed, i.e.,
?.
Method or purposes according to a third aspect of the present invention, wherein the composition is the composition in tablet form,
And it is prepared by the method included the following steps:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added (3~7 times of water
Amount, such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as
It is dried under reduced pressure), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, corn are added in rapid gained fine powder one step up
Starch (such as these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders), mixing
Uniformly;
(3) gained mixed material pelletized (for example, by using dry granulation), whole grain, magnesium stearate be added, mixed, tabletting.
Method or purposes according to a third aspect of the present invention, wherein also including calcium phosphate in the composition.At one
In embodiment, in terms of every 5 parts by weight deer whip, the additive amount of calcium phosphate is 3~7 parts by weight, for example, 4~6 parts by weight, such as
For 5 parts by weight.
Method or purposes according to a third aspect of the present invention, wherein calcium phosphate described in the composition is and marine fish
Oligomeric Gly-His-Lys are added in the composition after being pre-mixed.
Method or purposes according to a third aspect of the present invention, wherein also including silicified microcrystalline cellulose in the composition
Element.In one embodiment, in terms of every 5 parts by weight deer whip, the additive amount of silicified microcrystalline cellulose is 2~5 parts by weight, such as
For 3~4 parts by weight, for example, 3.5 parts by weight.
Method or purposes according to a third aspect of the present invention, wherein silicified microcrystalline cellulose described in the composition is
It is added in the composition in the stage for preparing composition addition maca.
In the method and step that describes of the present invention, although the specific steps of its description are in certain details or language description
Step different from described in the upper and example of following detailed description part, however, those skilled in the art according to
The detailed disclosure of full text of the present invention can summarize approach described above step completely.
Any embodiment in either present invention face can be combined with other embodiments, as long as they are not
It will appear contradiction.In addition, any technical characteristic can be adapted for other realities in any embodiment of either side of the present invention
The technical characteristic in scheme is applied, as long as they are not in contradiction.
The invention will be further described below.
All documents recited in the present invention, their full content are incorporated herein by reference, and if these are literary
When offering expressed meaning and the inconsistent present invention, it is subject to statement of the invention.In addition, the various terms that use of the present invention and
Phrase has that well known to a person skilled in the art general senses, nonetheless, the present invention remain desirable at this to these terms and
Phrase is described in more detail and explains, the term and phrase referred to is if any inconsistent with common art-recognized meanings, with institute's table of the present invention
Subject to the meaning stated.
The present inventor is by experimental study, it has been unexpectedly discovered that excellent technology effect is presented in the present composition
The excellent effect for improving human body kidney qi and improving renal function is especially presented in fruit, presents especially after adding deer's tail significant
Effect, although such as can be significantly improved when not adding extra large deer's tail human body kidney qi improve renal function effect it is obviously too late
Effect after adding deer's tail.
Composition of the invention, daily in terms of deer whip, give it is adult can be 0.02~2g deer whip/day amount, such as
0.02~1g deer whip/day, such as 0.02~0.5g deer whip/day, such as 0.05~0.5g deer whip/day.Since instant component is equal
For integration of drinking and medicinal herbs substance, usually not special limitation is provided, therefore the present composition amount of daily intaking can be according to specific
Use situation has biggish difference.
Deer whip is the external genital organs of animal in deer family sika deer or red deer male.After killing deer, penis and testis are extracted, it is cleared
Residual meat and grease, be fixed on plank air-dry.With it is coarse, glossy, be preferred without residual meat and grease, free from insect pests, drying person.
" Traditional Chinese Medicine in Sichuan will ": warm-natured, taste is salty pungent, nontoxic;Enter liver, kidney, bladder three to pass through;Control impotence, kidney deficiency syrigmus, married woman's cold uterus,
It fails to be impregnated for a long time, chronic testis inflammation.But the careful clothes of innate excess of YANG in the body person.Deer whip is easy to use, can steep in wine, and herbal cuisine is made, if old whip
It can directly eat it raw.Mei flower spirit, main product is in Jilin, Liaoning, Hebei and other places;Red deer whip, main product is in Heilungkiang, Jilin, Inner Mongol
The ground such as Gu.Effect: kidney tonifying essence, invigorating kidney yang, strengthening the essence, strong waist and knee.Cure mainly kidney deficiency strain, soreness of waist and knee joint, deafness and tinnitus, sun
Impotence, spermatorrhea, premature ejaculation, uterus cold infertile, leukorrhagia are thin.The effect of deer whip: deer whip is the external genital organs of animal in deer family, i.e. penis and testis
Ball.There is the effects of kidney tonifying, establishing-Yang, strengthening the essence.It can invigorate blood circulation, stimulating milk secretion, be used clinically for strain, soreness of waist and knee joint, finnitus due to the kidney deficiency, impotence
With the diseases such as women's uterus cold infertile.Deer whip contains protein, fat, steroid hormone, vitamin C, A and inorganic calcium, phosphorus, iron etc., there is benefit
Kidney yang, the function of benefiting essence-blood, for straining, soreness of waist and knee joint finnitus due to the kidney deficiency, impotence, fertility, sex dysfunction, as the deficiency of yang causes
Impotence, premature ejaculation and lumbocrural pain, have significant curative effect to woman infertility and postpartum agalorrhea.Deer whip in addition to medicinal, and
Carnivorous first-class raw material can be used for steeping in wine or with chicken, duck, goose, fish Baoshang or production high-grade dishes.Deer whip kidney tonifying, establishing-Yang, benefit
Essence, promoting blood circulation.The major functions: controlling strain, soreness of waist and knee joint, nephrasthenia deafness, tinnitus, impotence, uterus cold infertile.Target user: needing kidney tonifying
Man;The man for having a delicate constitution, being easy fatigue, having a pain in the back;Sterile person.
Deer kidney, the dry product for the kidney removed after being butchered for animal in deer family sika deer or red deer.As the mankind, deer kidney is responsible for
The balance of impurity, maintenance body fluid and electrolyte in filtering blood, finally generates urine per urethra and excretes;Also have simultaneously
Endocrine function is to adjust blood pressure.Distinctive enzyme is glycerokinase, phosphoenolpy ruvate carboxy kinase in kidney, they are ten
Divide important enzyme.It normally says, kidney is the total valve of human body body fluid system.
Deer's sinew (Liganentum Cervi), Chinese medicine name.For animal in deer family sika deer (Cervusnippon Temminck)
Or the tendon of red deer (Cervuselaphus Linnaeus) four limbs.After killing deer, four limbs are taken, extract deer's sinew out, retains hoof, washes
Only, it using fresh herb or dries in the shade.Sika deer dwells in mixed forest, upland meadow and the nearly edge of forest, is distributed in northeast, North China, East China, south China;
Red deer dwells in the sylvosteppe of mixed forest, high mountain, is distributed in the ground such as northeast, northwest and the Inner Mongol.Taste is salty, warm-natured, returns liver, kidney
Had effects that nourishing liver and kidney, strengthening the bones and muscles, wind-damp dispelling, is usually used in caused by liver and kidney deficiency, strain wound, rheumatic arthralgia, spasm, rheumatism absolutely
Arthralgia, brothers' inability, systremma, man's essence decline, asthenia of essence and blood, all deficient, waist and leg aches, podomere are weak.Deer's sinew
Medicine materical crude slice is in irregular flake, and golden yellow or brown color, glossy and transparent, matter is tough and tensile, the micro- raw meat of gas.Free from admixture and mould moth.
Deer's sinew is scalded just as deer's sinew, and body is heaved, and color is deepened, and matter is more crisp, gas micro-perfume.It is stored in drying receptacle, it is closed, set cool place
It is mould proof at dry or in lime cylinder, it is mothproof.
Deer's tail is the tail of animal in deer family sika deer or red deer, deer's tail is cut off by pygostyle, hang-up is dried in the shade;Or it will
The band hair deer's tail cut off, enters in water and infiltrates, take out, and removes the residual meat in root, grease, cuts off young pilose antler and outside Lao Pi, then floating with sea
Stone rubs light with the hands, is dried in the shade with line impaling ventilation, preferably to ted at postposition drying more.It is warm-natured, nontoxic, sweet-salty.Major function are as follows: 1.
" Qinghai medicinal material ": for tonic.Control pain in the loins, impotence." 2. Traditional Chinese Medicine in Sichuan will ": warm waist and knee, kidney-nourishing essence, controlling lumbar vertebrae pain cannot bend
It stretches, emission due to the kidney deficiency and dizzy tinnitus.Dry deer's tail, shape tubbiness is slightly cylindrical, and apex blunt circle, base portion is slightly wider, cuts off face
Irregularly.Band hair person is about 15 centimetres, has brown color hair outside, and with some white hair;Without hair, person is shorter, outside aubergine
It is smooth glossy to atropurpureus, often with a small number of wrinkle ditches.Matter is hard, the micro- raw meat of gas.With it is sturdy, shiny black, without hair.Completely person is
It is good.Generally preferably wild deer's tail, plum blossom deer's tail slight of stature is very few to use.
Venison (Musculus Cervi) is animal in deer family sika deer (Cervusnippon Temminck) or red deer
The meat of (Cervuselaphus Linnaeus).Sika deer dwells in mixed forest, upland meadow and the nearly edge of forest, be distributed in northeast,
North China, East China, south China;Red deer dwells in the sylvosteppe of mixed forest, high mountain, is distributed in the ground such as northeast, northwest and the Inner Mongol.Taste
Sweet, warm-natured, returns spleen, kidney channel have effects that benefiting qi and supporting yang, nourishing the blood to expel wind, are usually used in consumptive disease and win thin, the impotence soreness of waist, middle air port
It is out-of-the-way.Venison dry product be it is crosscutting or it is longitudinal sectional into strips or block-like muscle masses, differ in size, bundle of muscle fibers is obvious;Surface is yellow
Brown or dark brown, and be mixed with yellow-white and be translucent the fascia of shape, matter is lighter, tearable.Fresh goods be in kermesinus or reddish violet,
Matter is flexible.The gas smelling of fish or mutton, taste are micro- salty.
In the present invention as not specifically mentioned, used deer whip, deer's sinew, deer's tail, venison meet the People's Republic of China (PRC)
The standard criterion of agricultural industry criteria NY317-1997, wherein deer whip is the dry of the external genital organs removed after being butchered by stag
Product, deer's sinew are the dry products for the tendon that deer four limbs clean with a pointed instrument.Deer's tail is the dry product for the tail removed after deer is butchered, and venison is fresh venison dehydration
By the dry product of veterinary sanitary inspection qualification.In addition, used deer kidney is after deer is butchered in the present invention as not specifically mentioned
The dry product for the kidney removed, and the deer kidney also is compliant with the standard criterion of NY317-1997.
Fish oligopeptide (Oligopeptides of marine fish) powder in ocean is low molecular weight peptide, ocean fish oligopeptide
Powder is using pollution-free or the relatively small deep-sea flesh of fish of pollution, skin, bone as raw material, and purification is process, and is novel nutrition
The ingredient of healthy food.It is welcomed by the people as the cosmetics of raw material and additive, food using ocean fish oligopeptide powder.
Ocean fish oligopeptide powder standard GB/T/T22729-2008 came into effect on August 1st, 2009, and insider points out, sea
The appearance of foreign fish oligopeptide powder national standard is beneficial to the production and application of specification collagen oligopeptide, also will be helpful to push whole
A collagen industry goes on more healthy road for development.The ocean fish oligopeptide powder of low molecular weight is more advantageous to absorption.It is high
Grade nutritionists point out: the collagen in food, ten thousand dalton of molecular weight about 40-60 are difficult to be digested.
Even boiling the beef tendon soup changed, fish-skin soup, trotter soup completely, the absorptivity of human body is also only 20% or so.Only low molecule
The Gly-His-Lys of amount could be fully absorbed by human body.The stability of oligopeptide is far superior to common collagen molecules.They have more
Heat-resisting, acid and alkali-resistance does not allow the advantages of mutability, and need not move through pipe intestinal digesting decompose and can directly be absorption of human body,
Mitigate renal metabolism burden, provides high-quality protein that is more high-quality, being easier to absorption for you.Molecular weight 1000-3000 dalton with
Under ocean fish oligopeptide be oligopeptide, have the following characteristics that 1. selected superior raw material, zero addition: raw material is from remote depth
The high protein fingerling in sea, extracts high-quality oligopeptide from its skin, pure pollution-free;Hormone-free, preservative, antibiotic, pigment
Any preservative is not added in equal substances, not fatty and carbohydrate, keeps 100% pure natural characteristic.2. low molecule is easily inhaled
It receives: with the state-of-the-art low-temperature biological directional enzymatic technology removal fat in the world, purine substance, preparing extra small molecular weight
The ocean fish oligopeptide powder of (1000-3000 dalton), dissolubility is good, can dissolve water under room temperature rapidly, is formed evenly dispersed
Solution, absorptivity is up to 95% or more.3. high activity: raw material and human body compatibility are strong, and Advanced keeps marine fish low
Poly- peptide keeps original high activity.Ocean fish oligopeptide applies in the raw material of special diet food, for special population
Health restoration undoubtedly plays very important effect.Ocean fish oligopeptide belongs to one kind of collagen, this collagen
There is very big difference with the collagen to be originated from land resources.The collagen of land resources is mainly derived from animality food
Object.The corium of animal is rich in collagen, and there are also animal cartilages and bone, especially cartilage, is also enriched in collagen, this kind of
Food source is extensive, such as the skull, thigh bone, spinal bone of pig, chicken carcasses, duck skeleton, fish head, fish-bone, ox bone, sheep bone etc.;It is dynamic
The shank of object is covered on substantially tendon, fascia and corium etc. above, is rich in collagen in addition to bone;Animal tendon and
Fascia is collagenic connective tissue, is rich in collagen, this common group food is sirloin, Cowhells, deer's sinew, trotter etc.;Birds
Wing and claw etc., other than the organizational structures such as bone, tendon, corium, maximum content is exactly collagen.As it can be seen that land
The collagen of ground biology is white more from a wealth of sources than ocean fish oligopeptide advantage, low in cost.It compares, ocean fish oligopeptide is then
Better than the collagen of land resources, the reason is that, fish collagen content is very high, especially abyssal fishes.Fish whole body
There is collagen, type is different, is distributed variant, scale content highest, but this can not generally eat;The collagen egg of fish-skin
Bai Hanliang takes second place, but general fish can not strip fish-skin, and many people are also without that skillful peeling handicraft;Fish head and fish-bone
Content is also very high;And the collagen in the flesh of fish is distributed not perfectly flat weighing apparatus, most collagen concentrates on abdomen, that is, fish
Sirloin and cheek rear side.In abyssopelagic organism group, the collagen of fish is then the most outstanding, and the deep-sea shoal of fish is subject to
Pollution is few, and the self-purification capacity of marine ecosystems is strong, this is also to live in biology in seabed to have built a good days
Environment, and there are greatest origin in our human bodies and ocean, the active material of marine organisms and the affinity of human body are strong, old friend's class
As can drawing ocean Isin glue collagen from marine organisms, nutrition is then self-evident for the human body.Marine fish is oligomeric
Peptide effect: 1. can effectively solve the problem that skin and muscle moisture reduce problem, supplement collagen peptide in due course, skin can be made to keep young.
2. make it is calcareous combine closely with osteocyte, will not be lost or degenerate.3. it is transparent that cornea holding can be made to moisten, it is transparent to increase eyes
Degree.4. promoting muscle cell tight union, elasticity and gloss are made it have.5. adjusting endocrine, protection and strengthening viscera function.
6. binding domain-immunoglobulin increases immunity.
In the present invention as not specifically mentioned, used ocean fish oligopeptide powder is processed by deep-sea fish skin,
And meet the standard criterion of National Standard of the People's Republic of China GB/T22729-2008.
Maca (Maca) also known as Maca, Peruvian ginseng, maka, maca-maca, maino, ayak
Chichira, ayak willku etc. are similar to the rhizome of radish sample hypertrophy using it, originate in 3500~4500 meters of height above sea level of South America
Andes region, the ecotope Puno being mainly distributed in the middle part of Peru and Peru the southeastern city of Puno are Cruciferae
(Cruciferae) Lepidium (Lepidium) plant, Classification system Lepidium meyenii.In Chinese yunnan, Western China
The ground such as hiding, Bolivia are also distributed.Maca can be divided into black maca, purple maca and yellow maca according to condition and epidermis color
(including white maca).Wherein the content of the core index such as maca ene, macamide, vitamin and amino acid, black maca are significantly high
In purple maca, purple maca is significantly higher than yellow maca.Correspondingly, the growth conditions of black maca is the harshest, output is also minimum, purple Ma
Coffee takes second place.Black maca is most precious, and yield typically constitutes from 3%-5%;Purple maca accounts for 10%-15%.
Maca is the plateau plant of Cruciferae, originates in the plateau plant in 4000 meters of South America Peru Andes or more.
There is significant effect to balanced human's hormone secretion containing exclusive macamide and maca ene.Maca has antifatigue, raising essence
Protonatomic mass regains one's strength of body, and improves sleep, anti-climacteric, active to give birth to, enhancing memory and other effects.And maca is that men and women is suitable
, also have good adjustment effect to the climacteric syndrome of women.Special natural environment and climate required for maca (MACA).
It requires 3500 meters of height above sea level or more, and weather is special and soil is fertile, and day and night the temperature difference is up to 40 degree or more, and such place is in the whole world
All be it is rarely found, only have in the Yunnan-Guizhou Plateau and Qinghai-Tibet Platean of source area Andes and China excessively area such
Condition.The land area that global range can plant maca is limited, and a maca is planted in these limited soils
(MACA) after, soil needs to recuperate the several years to restore fertility, and otherwise soil cannot continue to cultivate.Although the U.S. and Japan are
Successful introduction, but mainly based on scientific research, since maca (MACA) growth conditions is very special and requires soil fertile
Fertile, the such place whole world is all very rare, and the place for having this condition can not realize mechanized cultivation, so maca
Global yield it is extremely low, be unable to satisfy substantially the whole world demand.The cultivated area that the U.S. and Japan are introduced a fine variety is seldom, wherein effectively
The content of composition is lower than the maca (MACA) that Peru originates in, and is also higher by tens times than Peru on labour costs, so valence
Lattice are expensive.But the U.S. and Japan are all very big to maca demand, so being still the largest maca importer so far.
Maca has obtained the relevant authentication of each Main Developed Countries in the world as health food, includes the U.S. in base
FDA.Moreover, maca (MACA) is also included among catalogue by FAO (Food and Agriculture Organization of the United Nation) (FAO), is by FAO (Food and Agriculture Organization of the United Nation)
Recommend edible one of safety food, to improve malnutritive people, unbalanced nutrition (life is good not to represent nutrition equilibrium),
It improves human body immune function and improves fecundity (sexuality) and absolutely not any toxic side effect.Not with other common agriculturals
It is that a kind of colloidal state needs are grown in rich soil with, maca (MACA), can not be applied during final-period management
Add other fertilizer.Under 4000 meters of height above sea level or more of specific condition, almost life forbidden zone does not need to kill using chemical agent
Worm is not available chemical agent weeding because Foliage Absorption is very capable yet, and plantation overall process uses manually completely, Er Qie
This unfrequented place, also without other industrial pollution, therefore this is a kind of real natural nuisance-free green food.
In addition, maca (MACA) has eaten thousands of years by local resident in Peru, always without addicted or pharmacological dependence clinic
Performance, so edible maca (MACA) or maca product are safe.Chinese yunnan Shanxi Academy of Agricultural Sciences high mountain economic plants
Research institute started in 2003 in 3000 meters of area above successful introductions of Yulong Mountain Yunnan height above sea level, and planting technology is more mature,
Cultivated area gradually expands, and starts to produce Ma with, Huize, yunnan, Shangri-la and other places in Lijiang, yunnan Yulong Xueshan one
Coffee has realized that scale is planted.Main producing region is distributed in the ground such as Yulong Mountain Yunnan, and quality can mutually be equal to Peru's maca quality
Beauty.Fresh maca (MACA) moisture content 10.4%, protein 10.2%, fatty 2.2%, carbohydrate 59%, fiber
8.5%, ash content 4.9%.Amino acid needed by human rich in, such as: arginine (9.94%), asparatate
(9.17%), glutamic acid (15.6%) and lysine (54.5%) etc..Unsaturated fatty acid in the fatty acid of maca (MACA)
Content accounts for 52.7% (its Linoleic acid 18.5%, linolenic acid 8.87%), contains glucosinolate (glucosinolates) sterol
With potassium, calcium, iron etc..Maca ene (macaenes) and macamide (mecamides) are contained in maca (MACA) lipid position, also wrap
Include N- benzyl caprylamide, pungent three acrylamide of certain herbaceous plants with big flowers of N- benzyl -16- hydroxyl -9- oxidation -10E, 12E, 14E-, -16 hydroxyl of N- benzyl -
The homologue of 9,16- pungent three acrylamides of certain herbaceous plants with big flowers of dioxy -10E, 12E, 14E- and other 17 maca enes and macamide.Maca ene
It is considered as one of the active principle that tool promotes sexual function in maca (MACA) extract with macamide.
Maca is rich in vigor nutrient, amino acid, vitamin and several mineral materials, also containing alkaloids, glucosinolate, steroid
The secondary metabolites such as alcohol and various bioactive components, maca is in reducing blood lipid, adjusting endocrine, enhancing sexual desire, therapeutic function
Energy obstacle, antifatigue, anti-oxidant, improvement climacteric syndrome, antitumor, treatment anaemia etc. have fine effect, right
Balanced human's diet nutritional, enhancing immune system and improvement inferior health have extraordinary effect.
In the present invention, if not otherwise indicated, used pueraria root powder be the Ministry of Public Health announce 2011 No. 13 about Ma
Coffee powder is maca involved in the bulletin of new resource food through drying and crushing resulting powder.
Rhizoma polygonati (mono- p306 of POLYGONATI RHIZOMA, CP2015), also known as: polygonatum sibiricum Redoute, yellow chicken dish, pen tube dish,
Claw ginseng, tendrilleaf solomonseal rhizome, achickenclaw ginseng.For HUANGJING ZANYU CAPSULE, rhizome it is horizontal walk, cylindric, tubercle expands.Impeller generator, stockless.Medicinal plant
Object has tonifying spleen, the effect of moistening lung and producing body fluid.Rhizoma polygonati is sweet, taste is flat, returns spleen, lung, kidney channel.Rhizoma polygonati has tonifying Qi as tonic
Yin-nourishing, invigorating the spleen, moistening lung, kidney-nourishing and other effects.Rhizoma polygonati is that rhizomes is cylindric, and since tubercle expands, " internode " one thick, one
Head is thin, has at thick one short branch (medicinal material made by this rhizomes type of Chinese medicinal herbal is referred to as polygonatum sibiricum Redoute), and diameter 1~
2 centimetres.Stem is 50~90 centimetres high, or up to 1 meter or more, is sometimes in climb up by holding on to shape.Impeller generator, every 4~6 pieces of wheel, strip lanceolar,
8~15 centimetres long, hook is rolled up or bent to 6~16 millimeters of wide (4~), apex fist.Inflorescence usually has 2~4 flowers, like at umbrella shape
Shape, total bennet is 1~2 centimetre long, and 4~10 millimeters of bennet long (2.5~) is bowed vertical;Bract is located at bennet base portion, film quality, bore shape or
Strip lanceolar, it is 3~5 millimeters long, have 1 arteries and veins;Perianth milky is to faint yellow, 9~12 millimeters of overall length, slightly hangs in the middle part of perianth tube
Contracting, sliver are about 4 millimeters;Filigree is 0.5~1 millimeter long, and anther is 2~3 millimeters long;Ovary is about 3 millimeters, long 5~7 milli of style
Rice.7~10 millimeters of berry diameter, black has 4~7 seeds.5~June of florescence, 8~September of fruiting period.Rhizoma polygonati is distributed in China
Heilungkiang, Jilin, Liaoning, Hebei, Shanxi, Shaanxi, the Inner Mongol, Ningxia, Gansu (east), Henan, Shandong, Anhui (east),
Zhejiang (northwestward).At raw hayashishita, shrubbery or hillside yin, 800-2800 meters of height above sea level.Korea, Mongolia and Soviet Union's eastern Siberia
Area also has.
The rhizomes of rhizoma polygonati contains steroid saponin, separated 2 furan steroid enol form saponins and 2 spirostene alcohol type saponins out.
Belong to the former: 26-O- β-D- glucopyranosyl -22-O- methyl-(25) S- furan steroid -5- alkene -3 β, 26- glycol 3-O- β -
Lycotetraose glucoside (26-O- β-D-glucopyranosyl-22-O-methyl-25 (S)-furost-5-ene-3 β, 26-
Diol3-O- β-lycotetraoside) i.e. Herba Polygoni sibirici glucoside A (sibiricoside-A) and 26-O- β-D- glucopyranose
- 25 (S)-furan steroid -5- alkene of base -22-O- methyl -3 β, 14 alpha, 26-triol 3-O- β-lycotetraose glucoside (26-O- β-D-
glucopyranosyl-22-O-methyl-25(S)-fruost-5-ene-3β,14α,26-triol 3-O-β-
Lycotetraoside) i.e. 14 Alpha-hydroxy Herba Polygoni sibirici glucoside A (14 α-hydroxysibiricoside A);Belong to the latter's
It is: ((23S, 25R) spiral shell steroid -5- alkene -3 β, 14 α, 23- triol 3-O- β-lycotetraoside) i.e. Herba Polygoni sibirici glucoside B
(sibiricoside B) and new bus draw time diosgenin-A3-O- β-lycotetraose glucoside (neoprazerigenin A 3-O-
β-lycotetraoside).Another A containing Siberian solomonseal rhizome polysaccharide, B, C, the relative molecular mass of three is all larger than 200,000, by glucose
(glucose), mannose (mannose) and galacturonic acid (galacturonicacid) be condensed according to molar ratio 6:26:1 and
At;A containing polygonatum rhizome oligosaccharide, B, C again, relative molecular mass are respectively 1630,862 and 472, are by fructose (fructose) and Portugal
8:1.4:1 and 2:1 are condensed grape sugar in molar ratio.
Rhizoma polygonati has resisting pathogenic microbes effect: in vitro test shows, rhizoma polygonati water proposition liquid (1:320) to typhoid bacillus,
Staphylococcus aureus, acid-fast bacilli have inhibiting effect, and 2% rhizoma polygonati has different journeys to common causative fungi in sabouraud culture medium
The inhibiting effect of degree.Influence of the rhizoma polygonati to blood glucose: rabbit stomach-filling huang jing extract, blood-sugar content increase gradually, then reduce.Rhizoma polygonati
Medicinal extract excessively high to blood glucose caused by adrenaline is in significant inhibiting effect.Rhizoma polygonati antifatigue effect: 17.67% concentration of rhizoma polygonati decoction
0.3ml/ is only injected intraperitoneally, and can extend mouse swimming time.Rhizoma polygonati antioxidation: 20% concentration of rhizoma polygonati decocting liquid, 13ml/ are only fed
Drink continuous 27 days, increases mouse liver superoxide dismutase (SOD) activity, myocardium lipofuscin content reduces.Rhizoma polygonati delays
Aging effect: rhizoma polygonati decoction, 20% concentration impregnate mulberry leaf and feed silkworm, play the role of extending the silkworm larva phase.Rhizoma polygonati hemostasis is made
With: only, only, aqueous fraction 20mg/ only, is injected intraperitoneally, to dry ice-n-butanol fraction 20mg/ rhizoma polygonati methanolic extract 40mg/
Methanol freezes mouse tail 1 minute, and the experiment of back-end crop method shows there is anastalsis, reduces mouse amount of bleeding.Rhizoma polygonati is to angiocarpy
Effect: 0.16~0.26g/kg of rhizoma polygonati aqueous extract intravenous injection, hence it is evident that increase anesthetized dog coronary flow;1.5g/kg intravenous injection,
There is antagonism to rabbit myocardial ischemia caused by pituitrin, fights T wave caused by pituitrin and increase, promote T wave different
Often restore in advance;12g/kg intraperitoneal injection, can enhance mouse to the tolerance of anoxic.Rhizoma polygonati antivirus action: Siberian solomonseal rhizome polysaccharide
0.2% ocular fluid eye drip, 6 times/day, or Siberian solomonseal rhizome polysaccharide 10mg/kg is added, and 2 times/day, to the experimental herpes simplex keratitis angle of rabbit
Film inflammation has therapeutic effect.Rhizoma polygonati is sweet, taste is flat, returns spleen, lung, kidney channel.With boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing function
Effect.Pharmacological action: 1, resisting pathogenic microbes acts on: in vitro test shows, rhizoma polygonati water proposes liquid (1:320) to typhoid bacillus, gold
Staphylococcus aureus, acid-fast bacilli have inhibiting effect, and 2% rhizoma polygonati has in various degree common causative fungi in sabouraud culture medium
Inhibiting effect;2, to the influence of blood glucose: rabbit stomach-filling huang jing extract, blood-sugar content increase gradually, then reduce.Huang jing extract
Excessively high to blood glucose caused by adrenaline is in significant inhibiting effect;3, antifatigue effect: 17.67% concentration 0.3ml/ of rhizoma polygonati decoction
It is only injected intraperitoneally, mouse swimming time can be extended;4, antioxidation: 20% concentration of rhizoma polygonati decocting liquid, 13ml/ only feed drink, continuously
27 days, increase mouse liver superoxide dismutase (SOD) activity, myocardium lipofuscin content reduces;5, delaying senility function:
Rhizoma polygonati decoction, 20% concentration impregnate mulberry leaf and feed silkworm, play the role of extending the silkworm larva phase;6, anastalsis: rhizoma polygonati methanol
Only, only, only, intraperitoneal injection freezes mouse to dry ice-methanol to aqueous fraction 20mg/ to n-butanol fraction 20mg/ to extract 40mg/
Tail portion 1 minute, the experiment of back-end crop method show there is anastalsis, reduce mouse amount of bleeding;7, to Cardiovascular: rhizoma polygonati aqueous extract
0.16~0.26g/kg intravenous injection, hence it is evident that increase anesthetized dog coronary flow;1.5g/kg intravenous injection, draws pituitrin
The rabbit myocardial ischemia risen has antagonism, fights T wave caused by pituitrin and increases, T wave is promoted to restore in advance extremely;12g/
Kg intraperitoneal injection, can enhance mouse to the tolerance of anoxic;8, antivirus action: 0.2% ocular fluid eye drip of Siberian solomonseal rhizome polysaccharide, 6 times/
It, or Siberian solomonseal rhizome polysaccharide 10mg/kg is added, 2 times/day, there is therapeutic effect to the experimental herpes simplex keratitis of rabbit;9,
Other effects: continuous 10 days, Movse Erythrocyte Membrane Na+, K+--ATP enzymatic activity can be improved in rhizoma polygonati decoction 6g/kg stomach-filling.40%
Rhizoma polygonati alcohol extract 0.3ml/ is only injected intraperitoneally, and can improve mouse cardiac muscle, liver, spleen histocyte DNA to the incorporation efficiency of 3H~TdR.
The 0.5g/ stomach-filling of rhizoma polygonati decoction makes mice plasma cAMP, and cGMP content declines, and more with cGMP decline, therefore cAMP/
CGMP ratio is greater than control group, rises to spleen tissue cAMP, cGMP content, but cAMP/cGMP ratio is without significant change.
Chinese yam (mono- p28 of DIOSCOREAE RHIZOMA, CP2015) is Dioscoreaceae plant Chinese yam Dioscorea
The dry rhizome of Opposita Thunb..It is excavated after winter cauline leaf is withered, cuts root head, cleaned, remove crust and fibrous root, done
It is dry, it practises and claims " hair yam slice ";Or crust is removed, and fresh-cut sheet is taken advantage of, it is dry, referred to as " yam slice ";Also there is selection loose straight
In dry Chinese yam , Zhi Cheongju water, it is dipped into without the dry heart, it is bored, both ends are trimmed, are twisted into plank cylindric, dries, polishing, practises title " light
Chinese yam ".Chinese yam is also known as Chinese yam, native potato, sweet potato Chinese yam, RHIIZOMA DIOSCOREAE from Henan of China, Chinese yam, white Chinese yam, is the herbal medicine that " China's book on Chinese herbal medicine " records, medicinal
Source is Dioscoreaceae plant Chinese yam dry rhizome.Chinese yam have nourish it is strong, it is aid digestion, hold back abnormal sweating, the effect of antidiarrheal, cure mainly spleen
Empty diarrhea, cough due to deficiency of the lung, diabetes quenches one's thirst, oliguria frequency, spermatorrhea, women's leukorrhagia and dyspeptic chronic enteritis.Chinese yam is most
It is suitable for being taken with ganoderma lucidum collocation, has the function of preventing and treating diabetes, Chinese yam is big promising on grocery trade and processing industry.Mountain
Medicine is primarily adapted for use in spleen deficiency, deficiency syndrome of the lung disease, kidney deficiency, deficiency of both qi and yin disease of quenching one's thirst.Chinese yam property is sweet, taste is flat, returns spleen, lung, kidney channel, tool
There is the effect of tonifying spleen nourishing the stomach, engender liquid and benefic lung, kidney tonifying arresting seminal emission.The major functions: spleen deficiency, chronic diarrhea, the deficiency syndrome of the lung, kidney deficiency, leukorrhagia, frequent micturition.Chinese yam makees
For a kind of medicinal and edible plant, the mankind eat from ancient times, are that the mankind eat earliest one of plant.Early in the poem of the poet-sage Tu Fu Tang Dynasty
In just have the well-known phrase of " filling the more Chinese yams of intestines ".Chinese yam stem tuber plumpness succulence, sweet tea but also silk floss not only, and with viscosity, it is delicious for eating warm-served food raw all.
According to academy of agricultural sciences of Shandong Province to the result of laboratory test of Chinese yam, averagely contain thick protein 14.48% in stem tuber, crude fibre 3.48%,
Starch 43.7%, sugar 1.14%, potassium 2.62%, phosphorus 0.2%, calcium 0.2%, magnesium 0.14%, ash content 5.51%, iron 53.57ppm,
Zinc 29.22ppm, copper 10.58ppm, manganese 5.38ppm.In 18 kinds of amino acid of necessary for human, 16 kinds are contained in Chinese yam.Generally
It says, every 100g Chinese yam moisture content 75g or so, 14.4~19.9g of carbohydrate, 1.5~2.2g of protein, fat 0.1~
0.2g, Dioscin 50ug and B family vitamin, vitamin C, vitamin E, carbohydrate is based on starch.It is glutinous in Chinese yam
Property the mucin that is combined by mannosan and globulin of substance.Modern science analysis shows, the maximum feature of Chinese yam is to contain
There is a large amount of mucin.Mucin is a kind of mixture of proteinpolysaccharide, has special health-care effect to human body, can prevent
Fat deposition keeps blood vessel elasticity on angiocarpy, and atherosclerosis is prevented to occur to early;Subcutaneous fat deposits can be reduced;
It can prevent the atrophy of connective tissue, the generation of the collagen diseases such as prevention rheumatoid arthritis, chorionitis.Dopamine contained by it, tool
There is expansion blood vessel, improve sanguimotor critical function, which occupies critical positions in the treatment.Chinese yam fine and tender taste, contains
There are profuse nutraceutical agents.Shennong's Herbal calls it, and " main strong middle qi-restoratives removes fever and chills perverse trend, tonifying middle-Jiao and Qi power, long flesh
Meat, long term usage normal hearing and eyesight ";((Japan hanako materia medica " say its " help the five internal organs, muscles and bones, long will to calm the nerves living, cure mainly and let out smart amnesia ";" book on Chinese herbal medicine
Detailed outline " think Chinese yam energy " kidney-nourishing gas, antidiarrheal dysentery, changes paralysed saliva, profit fur at strengthening the spleen and stomach ".In recent years studies have shown that Chinese yam have
There is induction to generate interferon, enhances the effect of immune function of human body.Its contained choline and lecithin help to improve man memory
Power, often feeding can body-building, delay senescence, be the favorite health-care good product of people institute.Based on Chinese yam, it is aided with what konjaku was made into
Bionic foods have the effect of full of nutrition, healthcare, skin maintenance and cosmetic benefits, are rare health-nutrition cuisines.Chinese yam is
The medicine in medicine, food in mountain.Health food, but also the medical value with recuperating disease can be not only made into.Compendium of Material Medica refers to
Out: Chinese yam controls weakness, treats general debility, decaptitating seborrheic dematitis, stop pain in the loins, relieving restlessness heat, bushing unsaturated vapor, reach heart hole, is more
Account, kidney-nourishing gas, strengthening the spleen and stomach, antidiarrheal dysentery, profit fur, it is raw to smash that patch is swollen, hard poison be controlled;Good wine soup in " Records of Tradition Chinese and Western Medicine in Combination "
Train soup with growing, Radix Astragali matched with Chinese yam, can control quench one's thirst, consumptive disease asthma it is inverse, often combine with these integration of drinking and medicinal herbs such as fructus lycii, mulberry fruit
Chinese medicine do tea bubble drink, can kidney-tonifying health-care, resistance building, preferable health care's effect can be played.Chinese yam has as follows
Effect: 1. Chinese medicine for lowering blood pressure Liuwei Dihuang Wans, Rehmanniae Bolus of Eight Ingredients, 'Guishao Dihuang ball etc. are all the famous prescriptions for having Chinese yam to be made into,
It is applied not only to treatment kidney deficiency illness, is also used to treat the illnesss such as hypertension, diabetes, asthma, neurasthenia and pain in the loins;2. delaying
Aging modern science proves that Chinese yam can be such that the enzymatic activity for accelerating organism aging significantly reduces.Rehmanniae Bolus of Eight Ingredients containing Chinese yam, it is main
Control sweating continuously due to deficiency after delivery.It protects the clear drop soup of member, protect the cold drop soup of member, haematemesis and nosebleed can be controlled;Cold leaching soup mixing paste drenches soup, can control leaching
Worm.Chinese yam can also control pulmonary tuberculosis, typhoid fever and gynaecological disease etc., this is all conducive to promote longevity;3. antitumor action Chinese yam stem tuber is rich
Containing polysaccharide, human immune system can be stimulated and adjusted.Therefore the health medicine for often making enhancing immunocompetence uses.Chinese yam polysaccharide pair
Cellular immunity suppression caused by cyclophosphamide has antagonism, and repressed cellular immune function can be made partly or entirely to restore
Normally.Chinese yam can also reinforce the phagocytosis of leucocyte.Such as, Liuwei Dihuang Wan can treat chronic nephritis, hypertension, diabetes,
The illnesss such as neurasthenia.The Pill of Anemarrhena, Phellodendrom and Rehmannia can treat the fire excess from yin deficiency disease such as ankylosing spondylitis and gynaecology's vaginal bleeding during pregnancy, pruritus vulvae, menostasis.
'Guishao Dihuang ball can treat otalgia tinnitus, deficiency of Yin spontaneous perspiration etc.;4. can control allantoin contained in skin disease Chinese yam has anesthesia town
The effect of pain can promote epithelial growth, anti-inflammatory and antibacterial, be usually used in treating rhagadia manus et pedis, ichthyosis and a variety of keratosa skins
Disease.
Raspberry (mono- p382 of CP2015) is the dry fruit of rosaceous plant rubus chingii Hu chingii Hu.Early summer
Fruit is removed stalk, leaf, sets and slightly scald in boiling water or slightly steam, taking-up is dry by harvesting when green greening Huang.Raspberry is a kind of rose
The xylophyta of section rubus is a kind of fruit, and fruit taste is sour-sweet, with delavay raspberry herb on the limb of plant.Raspberry has
Many alias, such as: raspberry covers basin, covers the basin certain kind of berries, tree plum, raspberry, the wild certain kind of berries, rasp berry, black Fischer.The fruit of raspberry is one
Kind aggregate fruit has red, and golden and black is used as fruit in America and Europe, in Chinese largely distribution but little known, only in northeast ground
There is a small amount of cultivation in area, more rare in the market.Raspberry plant can be used as medicine, and there are many drug value, fruit has tonifying kidney and strengthening yang
Effect.Raspberry seed oil belongs to unsaturated fatty acid, can promote the severe that of prostatic secretions and covers.Raspberry system shrub, it is 1-2 meters high;
Branch brown or bronzing, by villiform pubescence, sparsely grow prickle when young.3-7 pieces of leaflet, have 3 leaflets, sterile shoot sometimes on spray
Upper normal 5-7 leaflet, long avette or ellipse, terminal leaflet is often oval, shallowly splits sometimes, 3-8 centimetres long, 1.5-4.5 centimetres wide, top
Hold short tapering, basal circular, terminal leaflet base portion is closely heart-shaped, above hairless or sparsely grow pubescence, below it is close by canescence villus, side
Edge has irregular rough sawn tooth or weight sawtooth;Petiole is 3-6 centimetres long, and terminal leaflet handle is about 1 centimetre, by villiform pubescence and
Sparse spinule;Stipule is linear, has pubescence.Peanut spends axillary, total bennet and bennet at short racemes or less in side shoot top
It is close to be pierced by the needle of villiform pubescence and density not etc.;Bennet is 1-2 centimetres long;Bract is linear, has pubescence;Flower diameter 1-
1.5 centimetre;It is close by villiform pubescence and density not equal needle thorn outside calyx;Sepal ovum shape lanceolar, top tail point, outside
Edge has canescence villus, upright in flowers and fruits;Petal cochlear, by pubescence or hairless, white, base portion has wide pawl;Filigree
Width is flat, is longer than style;Style base portion and ovary are close by canescence villus.Fruit is subsphaeroidal, many juice, 1-1.4 centimetres of diameter, red
Color is orange-yellow, close tomentellate;The obvious hollow hole of core tool.The month at florescence 5-6, the fruiting period 8-9 month.Fructus Rubi actually aggregate fruit, by
Numerous drupe are polymerized, spherical, and top blunt circle, bottom is flatter, surface celadon or light brown, close tomentellate.It is small
Drupe is about in semilune, and the back side is swelled, and the outside of belly has protrusion, surface brown, and the back side and apex have canescence hair, and the outside of belly and two sides have
Netted dimpled grain.Matter is hard, includes 1, brown seed.Gas faint scent, taste are slightly sour, puckery.Raspberry property is sweet, sour, taste temperature.Return liver, kidney, wing
Guang warp.Raspberry is for controlling overstrain, consumptive disease, liver and kidney qi void aversion to cold, kidney qi deficiency inverse cough, impotence, the illness that disappears, diarrhea, reddish and whitish turbid urine.Have
Supplementing the kidney to control the nocturnal reducing urination, the effect of nourishing the liver to improve visual acuity, are commonly used in emission and spermatorrhea, enuresis frequent micturition, impotence and premature ejaculation, and mesh is secretly dim-sighted.
Fructus alpiniae oxyphyllae (mono- p291 of CP2015), Chinese medicine name, also known as: intelligence development, sub-, Zhai Ding of intelligence development.For zingiberaceous plant intelligence development
The dry mature fruit of Alpinia oxyphylla Miq.;Fruit is dried by harvesting when green redden or low temperature is dry between summer, autumn
It is dry.It is distributed in Guangdong and Hainan, also there is cultivation in Fujian, Guangxi, Yunnan.Saliva is taken the photograph with warming spleen and stopping diarrha, warms up the function of kidney reducing urination controlling nocturnal emission with astringent drugs
Effect.It is usually used in deficiency-cold in spleen and stomach, vomits, diarrhea, crymodynia in abdomen, the more salivas of mouth, enuresis with renal asthenia, frequent micturition, spermatorrhea, gonorrhoea.Warm-natured, taste
Pungent, returns spleen, kidney channel have warming spleen and stopping diarrha the effect of taking the photograph saliva, warm kidney reducing urination controlling nocturnal emission with astringent drugs.Acquisition processing: 2-3 after field planting, in 6-7
Month, when fruit falls off in light brown, White flesh, pulp is pungent with sweet tea, seed, selects fine day to cut fruit ear, removes carpopodium,
It dries or dries.Morphological feature: 1-3 meters of plant height;Stem is grown thickly;Rhizome is short, 3-5 centimetres long.Blade lanceolar, it is 25-35 centimetres long,
3-6 centimetres wide, top is gradually narrow, has tail point, base portion subcircular, and edge has deciduous setula;Petiole is short;Tip of a leaf film quality, 2 split;
It is 1-2 centimetres long, it is dilute longer, pubescence is dredged by light brown.Raceme is all contained in bud in a hat shape phyllary, Hua Shi
It entirely falls off, rachis is by extremely short pubescence;Pedicel is 1-2 millimeters long;Big bract is extremely short, film quality, brown;Calyx tubular, it is long
1.2 centimetres, side is cracked to middle part, and apex has 3 fissures, outer by pubescence;8-10 millimeters of corolla pipe range, corolla lobe is oval
Shape is about 1.8 centimetres, and 1 piece of rear is slightly larger, white, outer by thin pubescence;The raw staminodium in side bores shape, is about 2 millimeters;Lip
Obovate is about 2 centimetres, white powder and have red veins, first end margin ripple shape;Filigree is 1.2 centimetres long, and anther is about 7 millis
Rice;Ovary is close by villus.Spherical when capsule is fresh, spindle when doing is 1.5-2 centimetres long, about 1 centimetre wide, by pubescence, on pericarp
There are the vestiges of calyx tube on bossed vascular bundle lines, top;Seed is irregularly oblate, by faint yellow aril.Florescence: 3-
May;Fruiting period: the 4-9 month.Growing environment: it is born in the dark and damp place of hayashishita.It is distributed in Guangdong and Hainan, also there is cultivation in Fujian, Guangxi, Yunnan
Training.Medicinal Materials Characters: fruit spindle or ellipse, both ends are tapering, long 1.2-2cm, diameter 1-1.3cm, and surface brown is to greyish brown
Color has rough interrupted shape crown line 13-20 item, and apex has perianth residue, and base portion remains carpopodium or carpopodium trace, pericarp are thin
It is tough, it is close to seed, seed group is intermediate to have light brown diaphragm to be divided into Room 3, and every room has 6-11, seed, and seed is in irregular multi-panel
Shape, diameter 3-4mm, taupe have faint yellow aril, and there is the hilum of recess in outside of belly center, plant ridge trench.Gas fragrance, acrid flavour,
Slight bitter.It is preferred with a big, full, dense person of smell.Pharmacological action: 1, to the effect of cardiovascular system;2, anti-gastric injury effect;3,
Other effects: inhibit prostaglandin effect, increase peripheral blood leukocyte.Modern Application: Suoquan Wan: warming and invigorating kidney Yang, astringent method contracting
Urine.For frequent urination, night crouches the enuresis.
In the present invention, using to magnesium stearate at least conform to GB1886.91 standard, the xylitol used at least accords with
Close GB1886.234 standard, using to cornstarch at least conform to GB/T8885 standard, the maltodextrin used at least accords with
It closes GB/T20884 standard or they also is compliant with its respective standard in current edition " Chinese Pharmacopoeia ".In the present invention, make
The other auxiliary materials used should also conform to the regulation of relevant criterion.In addition, deer whip deer kidney piece pressed candy produced by the present invention also accords with
Close the corresponding specification of SB/T10347 standard.
The present invention is by largely testing, it was confirmed that technical solution of the present invention presents one or more unexpected beneficial
Effect.
Specific embodiment
The present invention can be further described by the following examples, however, the scope of the present invention and unlimited
In following embodiments.One of skill in the art, can be with it is understood that under the premise of without departing substantially from the spirit and scope of the present invention
Various change and modification are carried out to the present invention.The present invention carries out the material and test method arrived used in test general
And/or specific description.Although to realize the present invention many materials and operating method used in purpose be it is known in the art that
But the present invention is still described in this detail as much as possible.At least 10 kilograms of every batch of total amount of feeding when preparing composition below.
Embodiment 1: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 2 parts by weight of deer kidney, 3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 weight of venison
Part, 5 parts by weight of ocean fish oligopeptide powder, 5 parts by weight of pueraria root powder, 7 parts by weight of rhizoma polygonati, 8 parts by weight of Chinese yam, 8 parts by weight of raspberry,
8 parts by weight of fructus alpiniae oxyphyllae.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (5 times
Amount) (4 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) add that ocean fish oligopeptide powder, (these materials are can be by 60 for pueraria root powder in rapid gained fine powder one step up
The powder of mesh fine powder, if necessary in advance crushes them), be uniformly mixed to get.
Embodiment 2: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 1 parts by weight of deer kidney, 4 parts by weight of deer's sinew, 4 parts by weight of deer's tail, 9 weight of venison
Part, 4 parts by weight of ocean fish oligopeptide powder, 6 parts by weight of pueraria root powder, 6 parts by weight of rhizoma polygonati, 9 parts by weight of Chinese yam, 7 parts by weight of raspberry,
9 parts by weight of fructus alpiniae oxyphyllae.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (4 times
Amount) (2 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) add that ocean fish oligopeptide powder, (these materials are can be by 60 for pueraria root powder in rapid gained fine powder one step up
The powder of mesh fine powder, if necessary in advance crushes them), be uniformly mixed to get.
Embodiment 3: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 3 parts by weight of deer kidney, 2 parts by weight of deer's sinew, 6 parts by weight of deer's tail, 7 weight of venison
Part, 6 parts by weight of ocean fish oligopeptide powder, 4 parts by weight of pueraria root powder, 8 parts by weight of rhizoma polygonati, 7 parts by weight of Chinese yam, 9 parts by weight of raspberry,
7 parts by weight of fructus alpiniae oxyphyllae.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (6 times
Amount) (6 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) add that ocean fish oligopeptide powder, (these materials are can be by 60 for pueraria root powder in rapid gained fine powder one step up
The powder of mesh fine powder, if necessary in advance crushes them), be uniformly mixed to get.
Embodiment 4: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 2.5 parts by weight of deer kidney, 2.5 parts by weight of deer's sinew, 5.5 parts by weight of deer's tail, venison
7.5 parts by weight, 5.5 parts by weight of ocean fish oligopeptide powder, 5.5 parts by weight of pueraria root powder, 7.5 parts by weight of rhizoma polygonati, 8.5 weight of Chinese yam
Part, 7.5 parts by weight of raspberry, 8.5 parts by weight of fructus alpiniae oxyphyllae.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (7 times
Amount) (3 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) add that ocean fish oligopeptide powder, (these materials are can be by 60 for pueraria root powder in rapid gained fine powder one step up
The powder of mesh fine powder, if necessary in advance crushes them), be uniformly mixed to get.
Embodiment 5: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 1.5 parts by weight of deer kidney, 3.5 parts by weight of deer's sinew, 4.5 parts by weight of deer's tail, venison
8.5 parts by weight, 4.5 parts by weight of ocean fish oligopeptide powder, 5.5 parts by weight of pueraria root powder, 6.5 parts by weight of rhizoma polygonati, 8.5 weight of Chinese yam
Part, 7.5 parts by weight of raspberry, 8.5 parts by weight of fructus alpiniae oxyphyllae.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (3 times
Amount) (5 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) add that ocean fish oligopeptide powder, (these materials are can be by 60 for pueraria root powder in rapid gained fine powder one step up
The powder of mesh fine powder, if necessary in advance crushes them), be uniformly mixed to get.
Embodiment 6: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 2 parts by weight of deer kidney, 3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 weight of venison
Part, 5 parts by weight of ocean fish oligopeptide powder, 5 parts by weight of pueraria root powder, 7 parts by weight of rhizoma polygonati, 8 parts by weight of Chinese yam, 8 parts by weight of raspberry,
8 parts by weight of fructus alpiniae oxyphyllae, 22 parts by weight of xylitol, 2 parts by weight of magnesium stearate, 7 parts by weight of maltodextrin, 5 parts by weight of cornstarch.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (5 times
Amount) (4 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, corn are added in rapid gained fine powder one step up
Starch (these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders) is uniformly mixed;
(3) it by gained mixed material granulation (using dry granulation), whole grain, addition magnesium stearate, mixes, tabletting.Every
0.5 gram of slice weight.
Embodiment 7: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 3 parts by weight of deer kidney, 2 parts by weight of deer's sinew, 6 parts by weight of deer's tail, 7 weight of venison
Part, 6 parts by weight of ocean fish oligopeptide powder, 4 parts by weight of pueraria root powder, 8 parts by weight of rhizoma polygonati, 7 parts by weight of Chinese yam, 9 parts by weight of raspberry,
7 parts by weight of fructus alpiniae oxyphyllae, 25 parts by weight of xylitol, 1 parts by weight of magnesium stearate, 8 parts by weight of maltodextrin, 4 parts by weight of cornstarch.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (3 times
Amount) (2 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, corn are added in rapid gained fine powder one step up
Starch (these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders) is uniformly mixed;
(3) it by gained mixed material granulation (using dry granulation), whole grain, addition magnesium stearate, mixes, tabletting.Every
0.25 gram of slice weight.
Embodiment 8: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 1 parts by weight of deer kidney, 4 parts by weight of deer's sinew, 4 parts by weight of deer's tail, 9 weight of venison
Part, 4 parts by weight of ocean fish oligopeptide powder, 6 parts by weight of pueraria root powder, 6 parts by weight of rhizoma polygonati, 9 parts by weight of Chinese yam, 7 parts by weight of raspberry,
9 parts by weight of fructus alpiniae oxyphyllae, 20 parts by weight of xylitol, 3 parts by weight of magnesium stearate, 6 parts by weight of maltodextrin, 6 parts by weight of cornstarch.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (4 times
Amount) (3 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, corn are added in rapid gained fine powder one step up
Starch (these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders) is uniformly mixed;
(3) it by gained mixed material granulation (using dry granulation), whole grain, addition magnesium stearate, mixes, tabletting.Every
1 gram of slice weight.
Embodiment 9: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 1.5 parts by weight of deer kidney, 3.5 parts by weight of deer's sinew, 4.5 parts by weight of deer's tail, venison
8.5 parts by weight, 4.5 parts by weight of ocean fish oligopeptide powder, 5.5 parts by weight of pueraria root powder, 6.5 parts by weight of rhizoma polygonati, 8.5 weight of Chinese yam
Part, 7.5 parts by weight of raspberry, 8.5 parts by weight of fructus alpiniae oxyphyllae, 21 parts by weight of xylitol, 2.5 parts by weight of magnesium stearate, maltodextrin
6.5 parts by weight, 5.5 parts by weight of cornstarch.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (7 times
Amount) (4 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, corn are added in rapid gained fine powder one step up
Starch (these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders) is uniformly mixed;
(3) it by gained mixed material granulation (using dry granulation), whole grain, addition magnesium stearate, mixes, tabletting.Every
0.2 gram of slice weight.
Embodiment 10: composition is prepared
It is formulated (ratio): 5 parts by weight of deer whip, 2.5 parts by weight of deer kidney, 2.5 parts by weight of deer's sinew, 5.5 parts by weight of deer's tail, venison
7.5 parts by weight, 5.5 parts by weight of ocean fish oligopeptide powder, 4.5 parts by weight of pueraria root powder, 7.5 parts by weight of rhizoma polygonati, 7.5 weight of Chinese yam
Part, 8.5 parts by weight of raspberry, 7.5 parts by weight of fructus alpiniae oxyphyllae, 23 parts by weight of xylitol, 1.5 parts by weight of magnesium stearate, maltodextrin
7.5 parts by weight, 4.5 parts by weight of cornstarch.
Preparation method: (1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae is added water (6 times
Amount) (5 hours) are decocted, it is concentrated (agitating and heating concentration), dry (being dried under reduced pressure), being ground into fine powder, (being ground into can be by 60 mesh
The fine powder of sieve);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, corn are added in rapid gained fine powder one step up
Starch (these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders) is uniformly mixed;
(3) it by gained mixed material granulation (using dry granulation), whole grain, addition magnesium stearate, mixes, tabletting.Every
2 grams of slice weight.
Test example 1: tablet friability
Tablet friability is measured according to the version of Chinese Pharmacopoeia 2015 its " 0923 tablet friability inspection technique ", and standard is usual
It is qualified to provide that " less loss weight must not cross 1%, and must not detect the piece of fracture, cracking and crushing " calculates friability.
After measured, embodiment 6-10 gained tablet friability inspection less loss weight is in 2.42~3.87% ranges, not
Piece detection fracture and crushed, but there is the piece being cracked individually in every group of tablet.Supplement embodiment a: embodiment 6- is respectively referred to
10 formula and preparation method, different is only not add ocean fish oligopeptide powder, measures friability to five batches of tablets of gained, as a result subtracts
The piece of fracture, cracking and crushing is not detected in 0.54~0.81% range in weight loss.Supplement embodiment b: join respectively
According to the formula and preparation method of embodiment 6-10, different be only added respectively while adding ocean fish oligopeptide powder 5 parts by weight,
The calcium phosphate of 4 parts by weight, 6 parts by weight, 7 parts by weight, 3 parts by weight measures friability to five batches of tablets of gained, as a result less loss weight
In 0.37~0.72% range, and the piece of fracture, cracking and crushing is not detected, it is seen that adding a small amount of calcium phosphate can show
Writing improves tablet friability.
Test example 2: tablet hygroscopicity
Tablet hygroscopicity measuring method: if taking tablet dry plate (4~5 grams of total weight), precise weighing places a tablet into plate
In, it then moves in the closed container of relative humidity 85%, stands 48 hours, take out, accurately weighed tablet weight calculates tablet
Increase weight percentage;Show that tablet hygroscopicity is low when increasing weight percentage usually under this experimental condition less than 2%.After measured, implement
Example 6-10 gained tablet weight gain percentage has obvious hygroscopicity, although this hygroscopicity is logical in 4.86~7.62% ranges
It can often be overcome by preparation commercially available back or part overcomes it may be to the adverse effect of tablet, it is still desired to can drop
Agent of low hygroscopicity.Supplement embodiment c: respectively referring to the formula and preparation method of embodiment 6-10, and different is only in the same of addition maca
When add 3.5 parts by weight, 4 parts by weight, 3 parts by weight, 2 parts by weight, 5 parts of silicified microcrystalline cellulose respectively, to five batches of pieces of gained
Agent measures hygroscopicity, as a result increases weight percentage in 0.78~1.14% range, it is seen that add a small amount of silicified microcrystalline cellulose
The hygroscopicity of tablet can be significantly reduced.Supplement embodiment d: five kinds of tablets for having augmented calcium phosphate obtained by supplement embodiment b
On the basis of again respectively supplement supplement embodiment c described in weight silicified microcrystalline cellulose, obtain five kinds while augmenting silicified microcrystalline
The tablet of cellulose and calcium phosphate measures their hygroscopicity, increases weight percentage in 0.71~1.27% range;In addition,
Measure this five kinds while augmenting the friability of the tablet of silicified microcrystalline cellulose and calcium phosphate, as a result less loss weight 0.44~
In 0.91% range, and the piece of fracture, cracking and crushing is not detected.
Test example 3: the clinical effectiveness of composition raising human body kidney qi
With reference to the military refined document of text, (Wu Wenbin, etc., the discussion of T lymphocyte subgroup and kidney qi prosperity and decline rule, Liaoning Chinese medicine is miscellaneous
Will, 1995,22 (6): method 242) investigates the clinical effectiveness that composition improves human body kidney qi.
It healthy male volunteers 128, the age 23~48 years old, is randomly divided into tri- groups: A group of A, B, C and takes example 1 group conjunction
Object, once a day, dosage is 0.2g deer whip/day in terms of deer whip every time, is continuously taken 28 days;B group takes no deer's tail composition (ginseng
According to the formula of embodiment 1 and preparation method preparation, different is only to be not added with deer's tail), once a day, dosage is 0.2g in terms of deer whip every time
Deer whip/day is continuously taken 28 days;C group is taken no deer feed composition and (is prepared referring to the formula of embodiment 1 and preparation method, different is only
It is not added with venison, deer's sinew, deer's tail, deer whip, deer kidney), once a day, dosage and A group etc. are worked as, and are continuously taken 28 days.It is all tested
Person took respectively at the 0th day before composition and after taking composition within the 29th day, and extracting vein blood 1.0ml adds equivalent Hank liquid, sets leaching
On bar cell layering liquid, 2000r/min is centrifuged 20min, collects lymphocyte on glass slide, SPA garland method;It is thin to collect lymph
Born of the same parents add OKT, 37 DEG C of incubation 30min, wash 3 times, add SPA-IgG antibody after dry;37 DEG C of incubation 15min wash dry after stain
Color calculates the percentage of T3 and T4.
For the T3 or T4 of each subject, its 0th day value and the 29th day value are calculated, is subtracted the 0th day with the 29th day value
Value gained difference, multiplied by 100% gained percentage, characterizes the increment rate of this subject T3 or T4, then divided by the 0th day value
The average increment rate of tri- tested group of T3 or T4 of A, B, C is calculated again.As a result: A group T3 average increment rate is 124.3%, A group T4 flat
Equal increment rate 106.2%, B group T3 average increment rate are 136.2%, B group T4 average increment rate is 98.7%, C group T3 averagely increases
Rate is added to be 17.2%, C group T4 average increment rate is -9.7%.Result above discovery, the combination of the deer product additive such as no deer whip
Object cannot effectively improve T3 and T4 value, cannot effectively improve human body kidney qi, regardless of whether addition deer's tail can be mentioned significantly
High T3 and T4 value, to improve human body kidney qi.
Test example 4: the biology effect of composition for preventing and controlling chronic renal failure
With reference to Zhang Lingling document (Zhang Lingling, etc. the experimental study that, Jisheng Shenqi Wan adds taste prevention and treatment chronic renal failure,
TCM investigation, 2009,22 (1): method 21) investigates the biology effect of composition for preventing and controlling chronic renal failure.Gland is fast
Purine, NIAODUQING KELI (Sugarless type, 5g/ bags, Z20073256) and test remaining reagent used are commercially available.Animal point
Group: rat adaptable fed 7d is divided into Normal group, model control group, clearing preparation-Niaoduqing group, embodiment by weight and gender at random
1 composition group (is prepared, different is only to be not added with deer's tail), every group without deer's tail composition group referring to the formula of embodiment 1 and preparation method
10.
The foundation and medication of animal model: [Fu Xiaoqing etc., adenine make the chronic kidney function of kidney yang deficiency syndrome to reference literature
The Biochemical Research of energy failure rat model, Colleges Of Traditional Chinese Medicine Of Fujian's journal, 2003,13 (1): 22-24] method, from the 1st day of experiment
Start, daily modeling, model control group, clearing preparation-Niaoduqing group, example 1 group close object group, without deer's tail composition group the set time in the morning
Four groups of rats respectively give 3% gland fat purine suspension 10mL/kg/d stomach-filling, total 28d.Normal group physiological saline stomach-filling.Often
Day morning modeling, afternoon is to medical treatment.Clearing preparation-Niaoduqing group gives 25% uremic clear solution 10mL/kg/d stomach-filling;Example 1 group is closed
Object group and without deer's tail composition component do not give 60% mixed liquid in terms of deer whip dosage be 50mg deer whip/kg body weight/day;Normal control
Group and model control group respectively give physiological saline 10mL/kg/d stomach-filling;28d is administered altogether.Collection of specimens, observation and Testing index, system
Method reference literature is counted to carry out.
As a result:
(a) each group rat ordinary circumstance compares: the 28th day normal rats and state before experiment are similar, ingest normal, body
Long and weight obviously increases, and active active, reaction is quick, coat gloss, and two is just normal;Model control group rat ingests obviously
It reduces, energy obviously weakens, and slow in reacting, coat is sparse withered, and abdomen has different degrees of depilation, and mutually aggregation takes often
It is warm, hydrouria;Clearing preparation-Niaoduqing group and example 1 group conjunction object group are ingested, and situation is significantly more preferable compared with model control group, and energy is compared with mould
Type group is significantly stronger, and coat gloss is quick on the draw, and urine volume increases compared with model control group, and height and weight have in various degree
Increase, and example 1 group closes object group situation and is better than clearing preparation-Niaoduqing group;No deer's tail composition group animal situation be better than model control group but
It is not as good as clearing preparation-Niaoduqing group.This shows that 1 composition group of the embodiment of the present invention can obviously fight the chronic kidney of adenine initiation
Failure, but be obviously deteriorated without the effect for fighting chronic renal failure in the case of deer's tail.
(b) comparison of each group Rat 24 h quantity of proteinuria, RBC and Hb: compared with Normal group, remaining four groups
3 indexs have significant differences, and concrete outcome is shown in Table 1.
The comparison (x ± s) of table 1 each group Rat 24 h quantity of proteinuria, RBC and Hb
Group | Urine proteins (mg) | RBC(×1012) | Hb(g/L) |
Normal group | 2.17±0.52 | 6.7883±0.65 | 116.33±15.86 |
Model control group | 14.22±1.44 | 4.63±0.67 | 79.36±6.43 |
Clearing preparation-Niaoduqing group | 8.25±0.83 | 5.77±0.86 | 93.06±9.31 |
Example 1 group closes object group | 6.74±0.77 | 5.93±0.80 | 97.42±2.67 |
Without deer's tail composition group | 10.54±0.87 | 5.06±0.87 | 83.12±2.48 |
Note: Normal group, model control group, the result of clearing preparation-Niaoduqing group and Zhang Lingling document in table 1 and following table 2~4
As a result essentially identical.
(c) comparison of each group rat TNF-α, SOD and NO: compared with Normal group, remaining four groups 3 index difference
Statistically significant, concrete outcome is shown in Table 2.
The comparison (x ± s) of table 2 each group rat serum TNF-α, SOD and NO
Group | TNF-α(pg/mL) | SOD(Nu/mL) | NO(umol/L) |
Normal group | 37.52±1.45 | 98.46±6.93 | 33.42±5.87 |
Model control group | 48.34±1.22 | 69.73±5.52 | 55.69±6.04 |
Clearing preparation-Niaoduqing group | 45.58±0.74 | 84.26±6.96 | 45.87±5.46 |
Example 1 group closes object group | 40.24±1.46 | 93.43±6.82 | 37.54±4.18 |
Without deer's tail composition group | 44.83±1.37 | 81.34±7.02 | 47.75±5.83 |
(d) comparison of each group rat BUN and SCr: compared with Normal group, remaining four groups two indices has very
Significant difference, concrete outcome are shown in Table 3.
The comparison (x ± s) of table 3 each group rat BUN and SCr
(e) comparison of each group rat UA and CO2-CP: compared with Normal group, remaining four groups two indices difference is equal
Statistically significant, concrete outcome is shown in Table 4.
The comparison (x ± s) of table 4 each group rat UA and CO2-CP
Group | UA(mmol/L) | CO2-CP(kPa) |
Normal group | 41.63±10.21 | 19.76±1.32 |
Model control group | 104.38±13.22 | 12.12±1.21 |
Clearing preparation-Niaoduqing group | 78.64±14.35 | 13.14±0.41 |
Example 1 group closes object group | 68.31±6.44 | 16.34±0.75 |
Without deer's tail composition group | 82.36±11.03 | 13.35±0.52 |
(f) morphological changes of various tissue components:
(f1) visually observe: the kidney of Normal group is in semen viciae fabae sample appearance, and no enlargement, color bronzing quality is solid,
Glossy, section cortex bronzing, medullary substance light red, skin, medullary substance distinct, coating combination is tight, is not easily stripped.Other each groups
Compared with Normal group, kidney have different degrees of swelling (swelling degree: model control group > > without deer's tail composition group > urine
Malicious clear group > example 1 group closes object group), this shows that 1 composition of the embodiment of the present invention can be fought, and adenine is caused by kidney
Adverse effect, and its effect is more preferable than clearing preparation-Niaoduqing group and without deer's tail composition group.
(f2) HE dyes microscopically observation result: the glomerulus and renal tubule of Normal group are without pathological change, lumen
Interior nodeless mesh object deposition;Model control group: Malpighian corpuscle quantity significantly reduces, and glomerulus severe is congested, and adenine metabolism crystallization accounts for
According to most of glomerulus and renal tubule, renal tubule underwent compensatory enlargement, the gel-shaped cast of show dye, part in most of renal tubule
Replaced fibr tissue of the renal tubule by hyperplasia, more lymphocytic infiltration is seen therebetween, a small number of slight atrophys of glomerulus, individually
Glomerulus compensatory hypertrophy, surrounding tubular ectasia, renal cells cloudy swelling, visible most brownish black crystals in lumen
Deposition;Clearing preparation-Niaoduqing group, example 1 group close object group and without deer's tail composition group: Malpighian corpuscle quantity is slightly reduced, and glomerulus is slightly extremely
Moderate is congested (redness degree: no deer's tail composition group > clearing preparation-Niaoduqing group > example 1 group closes object group), there is the adenine of distinct program
Crystallization deposition is metabolized in glomerulus and renal tubule (crystallization deposition degree: no deer's tail composition group > clearing preparation-Niaoduqing group > example 1 group conjunction
Object group), the renal tubule lumen distention not involved, visible slight gel-shaped cast deposition, the focal fiber of interstitial in lumen
Group is woven with mild hyperplasia, and structure is normal, and glomerulus is more compared with model control group, remaining index is than model control group ideal.
As a result, it has been found that addition deer's tail ratio can more effectively improve renal function in the composition for not adding deer's tail.More than
As a result as it can be seen that the present composition can valuably enhance human body kidney qi and renal function.
Test example 5: composition adjusts equilibrium between yin and yang and then improves the effect test of energy
The energy of human body is related with its equilibrium between yin and yang, and Chinese traditional medicine and culture of health preserving are thought, the decline of energy
Have its source in yin and yang imbalance, improve human body energy be at all first carry out Yin Yang balancing.Chinese medicine in relation to equilibrium between yin and yang
It learns and biochemical theory has extensive and in-depth research.For example, Wang Yuhe etc. is in its paper (Wang Yuhe, etc. by Chinese medicine yin
Rising tone weighing apparatus is balanced with Th1/Th2,2008,31 (2): equilibrium between yin and yang and Th1/Th2 5) has been discussed in detail in ShanXi Chinese Medicine Academy journal
About the internal relation between theory of traditional Chinese medical science and biochemical theory between balance, it is believed that one of essential characteristic of tcm theory
It is Overall View, core content is exactly to balance.The generation of various diseases can be summarised as the destruction balanced between yin-yang, and entangle
Positive yin and yang imbalance, restoring equilibrium between yin and yang is the total principle for treating disease.The development of Immunology Today demonstrates Th1, Th2 cell
Between the two there is also mutual growth and decline, either party enhancing of both sides can inhibit another party.The generation of a variety of diseases can go out
The drift of existing Th1/Th2 again may be by restoring the intercellular balance of Th1/Th2 to achieve the purpose that treat disease.It is many
Disease is treated by traditional Chinese medicine, it is found that Th1/Th2 is unbalance and corrected.So between Th1/Th2 balance and Chinese medicine equilibrium between yin and yang
There is close correlations.The Th1 cytokines such as Th1 cell Major Secretory IL-2, IL-12, IFN-γ, TNF-beta, it leads
Mediating cellular immune response and cytotoxicity are wanted, the generation of Preinflammtory cytokine is caused, is resisting intracellular pathogen
It (including virus and bacterium), organ transplant rejection and plays an important role in the induction of autoimmunity disease, and mediates tardy
The super quick inflammatory reaction of type.Th2 cell generates the Th2 cytokines such as IL-4, IL-5, IL-6, IL-10, its main mediate humoral
It is immune, IgE is generated, eosinophil is activated, resists extracellular pathogen.The cell factor that every kind of cell generates both had been used as certainly
Body growth factor, and can influence each other.Under the action of the cell factor of these mutual antagonisms, Th1/Th2 drift can occur,
When Th1 cell dominance, inhibit humoral immune response, when Th2 cell dominance, inhibits cellullar immunologic response.Thl/Th2
Balance adjustment and the occurrence and development of many immune correlated diseases are closely connected.After pathogenic factor acts on body, cause part
Immune and nonimmune cell secretes a small amount of cell factor, and Th0 cell differentiation is caused to change, unbalance so as to cause Thl/Th2, and can
The cytokine levels for further influencing the secretion of two class cells are unbalance, and the gradually disorder of body based intracellular cvtokine network is eventually led to
The generation of disease.
Above-mentioned traditional Chinese medical theory is in Yao at fragrant document (Yao Chengfang, etc. hyperactivity of yang due to yin deficiency mouse Thl/Th2 type cytokines
The intervention study of drift phenomenon and Chinese medicine Zuogui Wan, journal of Shandong university (medicine), 2004,42 (3): is demonstrate,proved in 349)
It is real.In the present invention, the present embodiment investigates the present composition to hyperactivity of yang due to yin deficiency mouse at the method for fragrant document referring to above-mentioned Yao
The intervention effect of the drift phenomenon of Thl/Th2 type cytokines.It is extracted referring to Yao at 70% ethanol water of fragrant literature method
Zuogui Wan extracting solution is prepared (to be concentrated into containing crude drug 1.36g/ml), in addition 1 composition of the embodiment of the present invention is provided, combined without deer's tail
Object (referring to the formula of embodiment 1 and preparation method preparation, different is only to be not added with deer's tail), remaining agents useful for same and test method are joined
According to Yao at fragrant literature method.Experimental animal is divided into five groups, comprising: normal group, model group, Zuogui Wan group, example 1 group close object
Group, without deer's tail composition group;Wherein, the dosage of Zuogui Wan group is identical as document, and example 1 group closes object group and without deer's tail composition
It is 50mg deer whip/kg body weight/day that group gives 60% mixed liquid dosage in terms of deer whip respectively;It is identical as document, it is normal to organize animal freedom
It ingests while stomach-filling physiological saline, model group animal gives thyroxin tablet merging Chinese medicine folium sennae water and mention agent modeling, Zuogui Wan
Group, example 1 group close object group, without three groups of deer's tail composition group are the modeling corresponding Chinese medicine of stomach-filling daily simultaneously.
It is 50mg deer that example 1 group, which closes object group and do not give 60% mixed liquid dosage in terms of deer whip without deer's tail composition component,
Whip/kg body weight/day).Measure and calculate Th1 cytokines IFN-γ and IL-2 value and Th2 cytokines IL-4 and
IL-10 is calculated respectively with the Thl/Th2 of two parameter characterizations of IFN-γ/IL-10 and IL-2/IL-4.The results show that normal group,
Model group, two Thl/Th2 parameters of Zuogui Wan group and document are essentially identical, and concrete outcome is as follows: (a) IFN-γ/IL-10 value
Aspect, normal group, model group, Zuogui Wan group, example 1 group close object group, be respectively as follows: without deer's tail composition group 1.53 ±
0.72,2.08±0.83,1.67±0.41,1.56±0.58,1.88±0.79;(b) in terms of IL-2/IL-4 value, normal group, mould
Type group, Zuogui Wan group, example 1 group close object group, be respectively as follows: without deer's tail composition group 1.08 ± 0.32,1.41 ± 0.66,
1.04±0.27,1.06±0.38,1.26±0.72.The above results are as it can be seen that organize animal, the IFN- of model group relative to normal
γ/IL-10 value and IL-2/IL-4 value increase, and after animal takes Zuogui Wan and the present composition, IFN-γ/IL-10
Value and the Thl/Th2 of IL-2/IL-4 value reflection revert to intact animal state substantially, show that the present composition has and adjust
The effect of equilibrium between yin and yang, although the two Thl/Th2 references of no deer's tail composition group have recurrence undesirable.
In addition, average animal time of the five groups of animals of observation in 2 hours before off-test is condemned to death, normally organizes 1.46
± 0.32 hour, model group 0.37 ± 0.46 hour, Zuogui Wan group 1.24 ± 0.51 hours, example 1 group close object group 1.53 ±
0.48 hour, without deer's tail composition group 0.91 ± 0.26 hour, the amount of exercise of animal is able to reflect the energetic degree of animal,
To can reflect the energy of animal on the whole, as can be seen from the above results, the present composition is improving human body energy side
Face will have excellent results.
Test example 6: influence of the composition to mouse immune regulatory function
Immune is a kind of biological answer-reply process of body " identification " and " exclusion " non-antigen, to maintain intracorporal physiology
Balance.Immunity function is the basis of human health, immune dysfunction and it is low when, the energy of body fight infections can be reduced
Power reduces identification and removes the histocyte ability of itself aging, reduces killing and removes the energy of abnormal sudden change cell in vivo
Power leads to the decline of human body premunition and vis medicatrix naturae.And modern society, the accelerating rhythm of life, the increase of competitive pressure, make to be permitted
More people are in nervous working and learning state, and body, which is chronically at this tense situation, will inhibit immune function;Meanwhile tightly
Working and learning allow more people to have to convenient fast food, the unbalance of endotrophic element is caused, if body is long-term
In a state in which immunity of organisms can be made to decline, the sub-health state of body is eventually led to.A kind of immune guarantor as body
Shield property physiological reaction, the balance and stabilization of vivo environment are maintained by immune function, and immunologic dysfunction is then immunized
Property disease.Scientist's research is immunized according to the U.S., mankind's major part disease is attributed to immune system and goes wrong.Long-term spirit pressure
Power has an important influence the immune function of human body, professor Thomas of Thelma Hopkins medical college of the U.S. to 1337 volunteers into
The observation gone up to 18 years has been found that people is chronically at lonely, contradiction, disappointment, constrains state, just will affect vivo environment
Balance, thus resistance weaken.City now is lived in, everyone health is easy to be on the hazard, including air is dirty
Dye, drinking water pollution, environmental pollution, operating pressure, economic pressures, improper diet, bacterial virus etc., all these unfavorable health
Factor can cause immunity of organisms low, and being usually expressed as people's spirit cannot concentrate, memory loss, frequent burnout, be susceptible to suffer from
The sub-health status such as disease, aging ahead of time.It is more especially the crowd of occupation with mental labour, opposite stress is very big,
So that stress is put aside for a long time, brain overload operation, to cause immunity degradation, weak all over, dizzy eye is puckery, the heart
Throb with fear shortness of breath, insomnia forgetfulness etc..Immunocompromised person, easily catches a cold and epidemic disease, and the low person of permanent immunity power compares healthy population
It is easy to infect, any reason causes compromised immune, then bacterium, virus etc. will assemble in vivo, and cause human body sick.
The intracorporal immune system of people is the best weapons of system, has the effects that the infringement for resisting pathogenic microorganism.
This test example investigates influence of the present composition to mouse immune regulatory function, and specific test is as follows.Reagent and
Grouping: experimental animal is divided into five groups, including blank control group (giving water), Capsule Dendrobii group (167mg/kg), example 1 group
Close object group, 6 composition group of embodiment, without deer's tail composition group, example 1 group closes object group, 6 composition group of embodiment and without deer's tail
It is 50mg deer whip/kg body weight/day that composition component, which does not give 60% mixed liquid dosage in terms of deer whip,;Test method: according to being permitted, it is newly literary
Offer (Xu Tianxin, etc., the inspection of Capsule Dendrobii antifatigue effect, Zhejiang preventive medicine, 2002,14 (11): 80) its " 4.1 weight bearing
The method of swimming test ";As a result: blank control group (giving water), Capsule Dendrobii group (167mg/kg), example 1 group close object
Group, 6 composition group of embodiment, be respectively 268 ± 148 seconds without five groups of walking weight load mean values of deer's tail composition group, 862 ±
276 seconds (* *), 1326 ± 342 seconds (* * *), 1373 ± 328 seconds (* * *) and 418 ± 133 seconds (*) [compared with blank control group, *
* < 0.01 < 0.1, * * < 0.05, * *].The result shows that the present composition (whether adding auxiliary material) its biology effect is equal
Better than the composition that deer's tail is not added, there is extremely significant difference compared with blank control group, and effect is better than comparison medicine Tiepi Fengdou
Crystalline substance, has excellent antifatigue effect, and the long-term effect of this antifatigue effect is that the raising of immunity and inferior health are asked
The elimination of topic.
Test example 7: composition enhances the effect test of the proliferation of T lymphocyte
It is well known that the proliferative capacity of T lymphocyte and the immunity of organism have significant positive correlation in vivo, T lymph is thin
The then immunity enhancing of organism by force of born of the same parents' proliferative capacity.Referring to Li Qin document (Li Qin, etc. the immune function of dendrobium candidum particle enhancing
Energy Effect study, Pharmacology and Clinics of Chinese Materia Medica 2008;24 (1): method 53) carries out, and animal is divided into six groups: Normal group is (no
Carry out tumour and make film), model control group (make tumor model then be not administered be given only normal diet and drinking-water), not straight ginseng group (one
Kind there is the medicinal material for improving immunity function), (strong word is eaten to 5 taste side's capsules by a kind of health food for improving immunity, state
G20140081, primary raw material include: cordyceps sinensis, dendrobium candidum, American Ginseng, Radix Salviae Miltiorrhizae, Radix Notoginseng, and healthcare function is that enhancing is immune
Power) group, example 1 group close object group, without deer's tail composition group, and example 1 group is closed object group and is not given without deer's tail composition component
60% mixed liquid dosage in terms of deer whip is 50mg deer whip/kg body weight/day, and not straight ginseng group dosage is 2.2g/kg body weight/day, 5 taste sides
Capsules group dosage is 2g/kg body weight/day, and mouse armpit inoculates the modeling of S180 tumor cell suspension, and next day grouping is given not
Straight ginseng, 5 taste side's capsules, example 1 group close object, without deer's tail composition, are administered within continuous 12 days, then measure gulping down for macrophage
Bite the parameters such as function, the proliferation of T lymphocyte and differentiation.As a result: Normal group, model control group, not straight ginseng group, 5 taste sides
Capsules group, example 1 group close object the group, (increasing of reflection T lymphocyte of the cpm value of T lymphocyte without deer's tail composition group
Grow situation) be respectively as follows: 26372 ± 8437***, 3438 ± 628,5186 ± 2013*, 7281 ± 1893**, 14721 ±
4158***, 5621 ± 2617* [compared with model control group, * < 0.1, * < 0.01 * * < 0.05, * *].It is real with reference to Li Qin document
Apply 1 composition of example to tumor-bearing mice macrophage phagocytic function, to NK cell activity, to mice serum hemolysin reflection body fluid
Immune function be superior to not join directly group, 5 taste side's Capsules groups and without deer's tail composition group as a result, showing that the present composition has
There is the function of excellent raising organism immune power.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
Claims (10)
1. it is a kind of for adjust human-body sub-health and improve immunity composition, be made of the following components: deer whip, deer kidney,
Deer's sinew, deer's tail, venison, ocean fish oligopeptide powder, pueraria root powder, rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae.
2. composition according to claim 1 is health care product, health food, health drink or medical product.
3. composition according to claim 1, is made of the following components: 5 parts by weight of deer whip, 1~3 parts by weight of deer kidney, deer's sinew 2
~4 parts by weight, 4~6 parts by weight of deer's tail, 7~9 parts by weight of venison, 4~6 parts by weight of ocean fish oligopeptide powder, 4~6 weight of pueraria root powder
Measure part, 6~8 parts by weight of rhizoma polygonati, 7~9 parts by weight of Chinese yam, 7~9 parts by weight of raspberry, 7~9 parts by weight of fructus alpiniae oxyphyllae;Alternatively,
It is made of the following components: 5 parts by weight of deer whip, 1.5~2.5 parts by weight of deer kidney, 2.5~3.5 parts by weight of deer's sinew, deer's tail
4.5~5.5 parts by weight, 7.5~8.5 parts by weight of venison, 4.5~5.5 parts by weight of ocean fish oligopeptide powder, pueraria root powder 4.5~5.5
Parts by weight, 6.5~7.5 parts by weight of rhizoma polygonati, 7.5~8.5 parts by weight of Chinese yam, 7.5~8.5 parts by weight of raspberry, fructus alpiniae oxyphyllae 7.5~
8.5 parts by weight;Alternatively,
It is made of the following components: 5 parts by weight of deer whip, 2 parts by weight of deer kidney, 3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 weight of venison
Measure part, 5 parts by weight of ocean fish oligopeptide powder, 5 parts by weight of pueraria root powder, 7 parts by weight of rhizoma polygonati, 8 parts by weight of Chinese yam, 8 weight of raspberry
Part, 8 parts by weight of fructus alpiniae oxyphyllae.
4. composition according to claim 1, wherein also including xylitol;For example, in terms of every 5 parts by weight deer whip, xylitol
Additive amount is 20~25 parts by weight, for example, 21~23 parts by weight, for example, 22 parts by weight;Alternatively,
It wherein also include magnesium stearate;For example, the additive amount of magnesium stearate is 1~3 parts by weight, example in terms of every 5 parts by weight deer whip
For example 1.5~2.5 parts by weight, for example, 2 parts by weight;Alternatively,
It wherein also include maltodextrin;For example, the additive amount of maltodextrin is 6~8 parts by weight, example in terms of every 5 parts by weight deer whip
For example 6.5~7.5 parts by weight, for example, 7 parts by weight;Alternatively,
It wherein also include cornstarch;For example, the additive amount of cornstarch is 4~6 parts by weight, example in terms of every 5 parts by weight deer whip
For example 4.5~5.5 parts by weight, for example, 5 parts by weight.
5. composition according to claim 1 is made of following component: 5 parts by weight of deer whip, 1~3 parts by weight of deer kidney, deer's sinew 2
~4 parts by weight, 4~6 parts by weight of deer's tail, 7~9 parts by weight of venison, 4~6 parts by weight of ocean fish oligopeptide powder, 4~6 weight of pueraria root powder
Measure part, 6~8 parts by weight of rhizoma polygonati, 7~9 parts by weight of Chinese yam, 7~9 parts by weight of raspberry, 7~9 parts by weight of fructus alpiniae oxyphyllae, xylitol 20
~25 parts by weight, 1~3 parts by weight of magnesium stearate, 6~8 parts by weight of maltodextrin, 4~6 parts by weight of cornstarch;Alternatively,
It is made of following component: 5 parts by weight of deer whip, 1.5~2.5 parts by weight of deer kidney, 2.5~3.5 parts by weight of deer's sinew, deer's tail
4.5~5.5 parts by weight, 7.5~8.5 parts by weight of venison, 4.5~5.5 parts by weight of ocean fish oligopeptide powder, pueraria root powder 4.5~5.5
Parts by weight, 6.5~7.5 parts by weight of rhizoma polygonati, 7.5~8.5 parts by weight of Chinese yam, 7.5~8.5 parts by weight of raspberry, fructus alpiniae oxyphyllae 7.5~
8.5 parts by weight, 21~23 parts by weight of xylitol, 1.5~2.5 parts by weight of magnesium stearate, 6.5~7.5 parts by weight of maltodextrin, jade
4.5~5.5 parts by weight of rice starch;Alternatively,
It is made of following component: 5 parts by weight of deer whip, 2 parts by weight of deer kidney, 3 parts by weight of deer's sinew, 5 parts by weight of deer's tail, 8 weight of venison
Measure part, 5 parts by weight of ocean fish oligopeptide powder, 5 parts by weight of pueraria root powder, 7 parts by weight of rhizoma polygonati, 8 parts by weight of Chinese yam, 8 weight of raspberry
Part, 8 parts by weight of fructus alpiniae oxyphyllae, 22 parts by weight of xylitol, 2 parts by weight of magnesium stearate, 7 parts by weight of maltodextrin, 5 weight of cornstarch
Part.
6. composition according to claim 1 is prepared by the method included the following steps:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added into water (3~7 times of amounts, example
Such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as decompression is dry
It is dry), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) added in rapid gained fine powder one step up ocean fish oligopeptide powder, pueraria root powder and optional pharmaceutic adjuvant (such as this
A little materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders), be uniformly mixed to get;Or
Person
It is the composition in tablet form, and it is prepared by the method included the following steps:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added into water (3~7 times of amounts, example
Such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as decompression is dry
It is dry), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, cornstarch are added in rapid gained fine powder one step up
(such as these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders) is uniformly mixed;
(3) gained mixed material pelletized (for example, by using dry granulation), whole grain, magnesium stearate be added, mixed, tabletting;For example,
It wherein also include calcium phosphate;For example, wherein also including silicified microcrystalline cellulose.
7. the method for preparing any one of the claim 1-6 composition comprising following steps:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added into water (3~7 times of amounts, example
Such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as decompression is dry
It is dry), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) added in rapid gained fine powder one step up ocean fish oligopeptide powder, pueraria root powder and optional pharmaceutic adjuvant (such as this
A little materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders), be uniformly mixed to get;Or
Person,
The composition is the composition in tablet form, and is included the following steps:
(1) deer whip, deer kidney, deer's sinew, deer's tail, venison and rhizoma polygonati, Chinese yam, raspberry, fructus alpiniae oxyphyllae are added into water (3~7 times of amounts, example
Such as 4~6 times of amounts) (2~6 hours, such as 3~5 hours) are decocted, it is concentrated (such as agitating and heating concentration), dry (such as decompression is dry
It is dry), it is ground into fine powder (such as being ground into can be by fine powder of 60 meshes);
(2) ocean fish oligopeptide powder, pueraria root powder, xylitol, maltodextrin, cornstarch are added in rapid gained fine powder one step up
(such as these materials are that can be crushed in advance to them if necessary by the powder of 60 mesh fine powders) is uniformly mixed;
(3) gained mixed material pelletized (for example, by using dry granulation), whole grain, magnesium stearate be added, mixed, tabletting.
It include also calcium phosphate in the composition, such as in terms of every 5 parts by weight deer whip 8. method according to claim 7, phosphoric acid
The additive amount of calcium is 3~7 parts by weight, for example, 4~6 parts by weight, for example, 5 parts by weight;For example, calcium phosphate is low with marine fish
Poly- Gly-His-Lys are added in the composition after being pre-mixed.
It include also silicified microcrystalline cellulose in the composition, such as with every 5 parts by weight deer 9. method according to claim 7
Whip meter, the additive amount of silicified microcrystalline cellulose are 2~5 parts by weight, for example, 3~4 parts by weight, for example, 3.5 parts by weight;Example
Such as, wherein the silicified microcrystalline cellulose was added in the composition in the stage for preparing composition addition maca.
10. the method for adjusting human-body sub-health and improving immunity, this method includes applying right to subject in need to want
Seek any one of 1-6 composition;Alternatively, any one of claim 1-6 composition is strong for adjusting human body Asia in preparation
Purposes in the product of health and raising immunity;For example, the product is that health care product, health food, health drink or medicine produce
Product;Such as the composition is made of the following components: 5 parts by weight of deer whip, 3 parts by weight of deer kidney, 2 parts by weight of deer's sinew, 6 weight of deer's tail
Part, 6 parts by weight of ocean fish oligopeptide powder, 4 parts by weight of pueraria root powder, 8 parts by weight of rhizoma polygonati, 7 parts by weight of Chinese yam, is covered 7 parts by weight of venison
9 parts by weight of basin, 7 parts by weight of fructus alpiniae oxyphyllae.
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CN114523499A (en) * | 2022-01-07 | 2022-05-24 | 南京中医药大学 | Body resistance strengthening and blood enriching dietary therapy formula for treating bone marrow suppression and standard preparation device and process thereof |
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CN107308392A (en) * | 2017-06-23 | 2017-11-03 | 禹州市鼎信中药科技有限公司 | A kind of maca cordyceps and ginseng alternative tea |
CN108210815A (en) * | 2018-02-06 | 2018-06-29 | 江西天元药业有限公司 | A kind of strengthen immunity, anti-aging, the cream taste for improving male's renal function |
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CN107308392A (en) * | 2017-06-23 | 2017-11-03 | 禹州市鼎信中药科技有限公司 | A kind of maca cordyceps and ginseng alternative tea |
CN108210815A (en) * | 2018-02-06 | 2018-06-29 | 江西天元药业有限公司 | A kind of strengthen immunity, anti-aging, the cream taste for improving male's renal function |
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CN114523499A (en) * | 2022-01-07 | 2022-05-24 | 南京中医药大学 | Body resistance strengthening and blood enriching dietary therapy formula for treating bone marrow suppression and standard preparation device and process thereof |
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