CN103191284A - Dragon blood spraying film agent applied to superficial wound and preparation technology thereof - Google Patents
Dragon blood spraying film agent applied to superficial wound and preparation technology thereof Download PDFInfo
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- CN103191284A CN103191284A CN2013100908943A CN201310090894A CN103191284A CN 103191284 A CN103191284 A CN 103191284A CN 2013100908943 A CN2013100908943 A CN 2013100908943A CN 201310090894 A CN201310090894 A CN 201310090894A CN 103191284 A CN103191284 A CN 103191284A
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- sanguis draxonis
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- spraying membrane
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Abstract
The invention discloses a dragon blood spraying film agent applied to a superficial wound and a preparation technology thereof. The dragon blood spraying film agent is characterized by comprising the following components by weight percent of 1-3% of dragon blood, 2-4% of borneol, 2-6% of polyvinylpyrrolidone, 1-3% of polyethylene glycol 2000, 0.5-2% of methylcellulose, 0.5-2% of ethyecellulose, 0.5-3% of polyving alcohol, 0.01-0.5% of glycerol, 40-70% of ethanol and the balance of distilled water. The preparation technology comprises the steps of dissolving the dragon blood and the borneol drug into solution A by the ethanol with the weight percent; evenly agitating the polyvinylpyrrolidone, the polyethylene glycol 2000, the methylcellulose, the ethyecellulose and the polyving alcohol into the distilled water to swell for 24 hours to prepare solution B, mixing the solution A with the solution B, blending the glycerol, and charging into a pressure spray bottle, and finally obtaining the dragon blood spraying film agent. The spraying film agent sprays the solution containing a drug into fog to be attached to the skin surface to quickly form a film under the effects of bottle pressure and the nozzle pressure. The spray film agent has the effects of stopping bleeding, inhibiting bacterium, healing sore and relieving pain, and is especially suitable for the symptoms such as small-area burns and scalds, scratch, bruise and unhealing score.
Description
Technical field
The invention belongs to field of medical technology, be particularly related to the Sanguis Draxonis spraying membrane and the preparation technology thereof that are used for the treatment of the shallow wound, more specifically, prepare a kind of contain Sanguis Draxonis have antibacterial, stop blooding, hold back effect such as skin ulcer, the spraying membrane of effect such as be used for trauma hemostasis, the convergence open sore part, protect from infection.
Background technology
Sanguis Draxonis is that China is used for the medicine resource of import substitution Sanguis Draxonis, is the resin that the fat xylem extracts that contains of Liliaceae dracaena Dracaena cochinchinensis Dracaena cochinchinensis (Lour.) S.C.Chen, and main product is in south of Yunnan and south Guangxi.Have effects such as blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, astringing to arrest bleeding, hard masses softening and resolving, promoting tissue regeneration and ulcer healing.Clinical in cardiovascular disease; traumatic injury; burn and scald; decubital ulcer; hemorrhoid; cervical erosion; hysteromyoma; multiple disease such as colitis; particularly traumatic hemorrhage and digestive tract hemorrhage there is significant curative effect; title with " hemostasis panacea "; along with the market demand increases; the Resina Draconis-drug resource is more and more deficienter; and tradition use to adopt Resina Draconis-drug directly to spread on wound to show; not only use inconvenience; and bioavailability is low; cause a large amount of wastes of medical material; disclosure of the Invention has been arranged kind Sanguis Draxonis sheet (CN 102872303 A) of applying ointment or plaster; limited by dosage form, carry inconvenience, so invent a kind of efficient; convenient Dragonis sanguis preparation; can solve increasingly serious crisis of resource, also can bring convenience for use.Spray-filming agent is that rising in recent years a kind of has slow-releasing and controlled-releasing action, the new dosage form of lasting percutaneous dosing, medicine nebulizes and is sprayed on skin surface film forming rapidly under the effect of high-molecular bone frame material, itself just has permeable watertight the high-molecular bone frame material, antibacterial effect injures outside in the body surface administration gradually and is used widely.
Summary of the invention
The present invention is intended to solve the problems referred to above that prior art exists, and announces following technical scheme:
Take off and state the percentage quality than component: Sanguis Draxonis 1%-3%, Borneolum Syntheticum 2%-4%, polyvinylpyrrolidone 2%-6%, Macrogol 2000 1%-3%, methylcellulose 0.5%-2%, ethyl cellulose 0.5%-2%, polyvinyl alcohol 0.5%-3%, glycerol 0.01%-0.5%, ethanol 40%-70%, all the other are made up of distilled water.Be solution A with dissolve with ethanol Sanguis Draxonis and the Borneolum Syntheticum medical material of above-mentioned weight percent, in distilled water, stir swelling 24 hours of polyvinylpyrrolidone, Macrogol 2000, methylcellulose, ethyl cellulose, polyvinyl alcohol, make solution B, mixed solution A and solution B, glycerol is in harmonious proportion, in the pressure of packing into the spray bottle, finally obtain Sanguis Draxonis spraying membrane, this spraying membrane in bottle or under the sprinkler pressure effect will contain the medicine spray solution rapid film forming in Dermallly affixed surface that nebulizes.Advantages such as this dosage form has easy to carry, and is easy-to-use, and the medical material bioavailability is big.
The present invention further discloses the preparation technology of Sanguis Draxonis spraying membrane, it is characterized in that carrying out according to the following steps:
1, take by weighing the 1.5g Resina Draconis-drug, Borneolum Syntheticum 3g is dissolved in the 50mL dehydrated alcohol, and dissolving is solution A fully.
2, take by weighing polyvinylpyrrolidone 3g, Macrogol 2000 2g, methylcellulose 1g, ethyl cellulose 1g, polyvinyl alcohol 1.5g is dissolved in the 40mL distilled water and stirs, swelling 24 hours makes its whole dissolvings, obtains solution B.
3, solution A is added in the solution B, stir, and add 0.2g glycerol and be in harmonious proportion, do not have precipitation and separates out.
4, the solution that obtains in the step 3 is packed in the spray bottle, under the sprinkler pressure effect, can be with liquid atomisation in the bottle, this medicine is attached to skin surface film forming rapidly.
The above-mentioned spray-filming agent that obtains can be applicable to small size burn and scald, scratch, scuffing and the open sore part and does not hold back, and has the effect that skin ulcer is held back in hemostasis, inhibiting bacteria and diminishing inflammation, pain relieving.
The specific embodiment
The preparation of embodiment 1 Sanguis Draxonis spraying membrane
1, take by weighing the 1.5g Resina Draconis-drug, Borneolum Syntheticum 3g is dissolved in the 50mL dehydrated alcohol, and dissolving is solution A fully.
2, take by weighing polyvinylpyrrolidone 3g, Macrogol 2000 2g, methylcellulose 1g, ethyl cellulose 1g, polyvinyl alcohol 1.5g is dissolved in the 40mL distilled water and stirs, swelling 24 hours makes its whole dissolvings, obtains solution B.
3, solution A is added in the solution B, stir, and add 0.2g glycerol and be in harmonious proportion, do not have precipitation and separates out.
4, the solution that obtains in the step 3 is packed in the spray bottle, under the sprinkler pressure effect, can be with liquid atomisation in the bottle, this medicine is attached to skin surface film forming rapidly.
The preparation of embodiment 2 Sanguis Draxonis spraying membrane
1, take by weighing the 2g Resina Draconis-drug, Borneolum Syntheticum 4g is dissolved in the 50mL dehydrated alcohol, and dissolving is solution A fully.
2, take by weighing polyvinylpyrrolidone 6g, Macrogol 2000 3g, methylcellulose 2g, ethyl cellulose 2g, polyvinyl alcohol 3g is dissolved in the 70mL distilled water and stirs, swelling 24 hours makes its whole dissolvings, obtains solution B.
3, solution A is added in the solution B, stir, and add 0.5g glycerol and be in harmonious proportion, do not have precipitation and separates out.
4, the solution that obtains in the step 3 is packed in the spray bottle, under the sprinkler pressure effect, can be with liquid atomisation in the bottle, this medicine is attached to skin surface film forming rapidly.
The preparation of embodiment 3 Sanguis Draxonis spraying membrane
1, take by weighing the 1g Resina Draconis-drug, Borneolum Syntheticum 2g is dissolved in the 40mL dehydrated alcohol, and dissolving is solution A fully.
2, take by weighing polyvinylpyrrolidone 2g, Macrogol 2000 1g, methylcellulose 0.5g, ethyl cellulose 0.5g, polyvinyl alcohol 0.5g is dissolved in the 50mL distilled water and stirs, swelling 24 hours makes its whole dissolvings, obtains solution B.
3, solution A is added in the solution B, stir, and add 0.01g glycerol and be in harmonious proportion, do not have precipitation and separates out.
4, the solution that obtains in the step 3 is packed in the spray bottle, under the sprinkler pressure effect, can be with liquid atomisation in the bottle, this medicine is attached to skin surface film forming rapidly.
The preparation of embodiment 4 Sanguis Draxonis spraying membrane
1, take by weighing the 1g Resina Draconis-drug, Borneolum Syntheticum 1.5g is dissolved in the 40mL dehydrated alcohol, and dissolving is solution A fully.
2, take by weighing polyvinylpyrrolidone 1g, Macrogol 2000 3g, methylcellulose 0.7g, ethyl cellulose 0.4g, polyvinyl alcohol 0.8g is dissolved in the 56mL distilled water and stirs, swelling 24 hours makes its whole dissolvings, obtains solution B.
3, solution A is added in the solution B, stir, and add 0.04g glycerol and be in harmonious proportion, do not have precipitation and separates out.
4, the solution that obtains in the step 3 is packed in the spray bottle, under the sprinkler pressure effect, can be with liquid atomisation in the bottle, this medicine is attached to skin surface film forming rapidly.
Claims (4)
1. Sanguis Draxonis spraying membrane and preparation technology thereof who is applied to the shallow wound is characterized in that this spraying membrane is made up of Sanguis Draxonis, polyvinylpyrrolidone K30, Macrogol 2000, methylcellulose, ethyl cellulose, polyvinyl alcohol, glycerol, ethanol, distilled water.
2. as claim item 1 described a kind of Sanguis Draxonis spraying membrane and preparation technology thereof who is applied to the shallow wound, it is characterized in that being made up of the percentage ratio of following prescription: Sanguis Draxonis 1%-3%, Borneolum Syntheticum 2%-4%, polyvinylpyrrolidone 2%-6%, Macrogol 2000 1%-3%, methylcellulose 0.5%-2%, ethyl cellulose 0.5%-2%, polyvinyl alcohol 0.5%-3%, glycerol 0.01%-0.5%, ethanol 40%-70%, all the other are made up of distilled water.
3. as claim item 1 described a kind of Sanguis Draxonis spraying membrane and preparation technology thereof who is applied to the shallow wound, it is characterized in that preparation technology is that sharp to require dissolve with ethanol Sanguis Draxonis and the Borneolum Syntheticum medical material of 2 a described ratio be solution A to weighting, the sharp polyvinylpyrrolidone that requires ratio in the item 2 of weighting, Macrogol 2000, methylcellulose, ethyl cellulose, polyvinyl alcohol places stir swelling 24 hours of distilled water, make solution B, mixed solution A and solution B, adding right requires 2 a described ratio glycerol to be in harmonious proportion, in the pressure of packing into the spray bottle, finally obtain Sanguis Draxonis spraying membrane, this spraying membrane in bottle or under the sprinkler pressure effect will contain the medicine spray solution rapid film forming in Dermallly affixed surface that nebulizes.
4. as a kind of Sanguis Draxonis spraying membrane and preparation technology thereof who is applied to the shallow wound as described in the claim item 3, it is characterized in that the spraying membrane that obtains can be applicable to the shallow wound, particularly small size burn and scald, scuffing, scratch, the open sore part such as do not hold back at symptom.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100908943A CN103191284A (en) | 2013-03-21 | 2013-03-21 | Dragon blood spraying film agent applied to superficial wound and preparation technology thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2013100908943A CN103191284A (en) | 2013-03-21 | 2013-03-21 | Dragon blood spraying film agent applied to superficial wound and preparation technology thereof |
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| CN103191284A true CN103191284A (en) | 2013-07-10 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919967A (en) * | 2014-04-03 | 2014-07-16 | 张荣平 | Dracaena cochinchinensis resin compound and application thereof in preparation of medicines for treating trauma |
| CN106109845A (en) * | 2016-05-05 | 2016-11-16 | 中国医学科学院药用植物研究所云南分所 | For treating the Sanguis Draxonis spray of pressure ulcer and inspection thereof and preparation method |
| CN108014239A (en) * | 2017-12-28 | 2018-05-11 | 宁波高新区若水智创科技有限公司 | A kind of Chinese medicine preparation of wound hemostasis anti-inflammatory |
| CN108175822A (en) * | 2017-12-27 | 2018-06-19 | 广西中医药大学制药厂 | A kind of Resina Draconis spray-filming agent and preparation method thereof |
| CN108578540A (en) * | 2018-06-05 | 2018-09-28 | 深圳市旷逸生物科技有限公司 | A kind of biologic formulation and preparation method thereof for inhibiting scar and promoting wound healing |
| CN109893539A (en) * | 2019-03-26 | 2019-06-18 | 青岛九远医疗科技有限公司 | A kind of composite antibacterial aerosol and preparation method thereof |
| CN112546290A (en) * | 2020-12-17 | 2021-03-26 | 江苏耐雀生物工程技术有限公司 | Antibacterial and anti-inflammatory liquid adhesive bandage and preparation method thereof |
| WO2022126628A1 (en) * | 2020-12-18 | 2022-06-23 | 江苏奇力康皮肤药业有限公司 | Liquid adhesive bandage and preparation method therefor |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698824A (en) * | 2005-06-09 | 2005-11-23 | 张帆 | Externally applied plaster for treating local trauma |
| CN1899600A (en) * | 2005-07-22 | 2007-01-24 | 上海高科联合生物技术研发有限公司 | Antibiotic peptide spray film forming agent and its preparing method |
| CN101879283A (en) * | 2010-06-13 | 2010-11-10 | 中国人民解放军第三军医大学 | Novel membrane spraying preparation for skin trauma and preparation method |
| CN102204887A (en) * | 2011-06-09 | 2011-10-05 | 浙江浙北药业有限公司 | In-situ formed acyclovir spraying agent and preparation method thereof |
| CN102872303A (en) * | 2012-10-31 | 2013-01-16 | 贾国平 | Resina draconis application paster as well as preparation and detection methods |
-
2013
- 2013-03-21 CN CN2013100908943A patent/CN103191284A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1698824A (en) * | 2005-06-09 | 2005-11-23 | 张帆 | Externally applied plaster for treating local trauma |
| CN1899600A (en) * | 2005-07-22 | 2007-01-24 | 上海高科联合生物技术研发有限公司 | Antibiotic peptide spray film forming agent and its preparing method |
| CN101879283A (en) * | 2010-06-13 | 2010-11-10 | 中国人民解放军第三军医大学 | Novel membrane spraying preparation for skin trauma and preparation method |
| CN102204887A (en) * | 2011-06-09 | 2011-10-05 | 浙江浙北药业有限公司 | In-situ formed acyclovir spraying agent and preparation method thereof |
| CN102872303A (en) * | 2012-10-31 | 2013-01-16 | 贾国平 | Resina draconis application paster as well as preparation and detection methods |
Non-Patent Citations (3)
| Title |
|---|
| 孟庆芬等: "血竭愈烫喷雾剂的研制", 《重庆医学》 * |
| 张传海等: "复方血竭膜的研制与疗效观察", 《时珍国医国药》 * |
| 陈素华等: "复方血竭膜的研制及临床应用", 《华西口腔医学杂志》 * |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103919967A (en) * | 2014-04-03 | 2014-07-16 | 张荣平 | Dracaena cochinchinensis resin compound and application thereof in preparation of medicines for treating trauma |
| CN103919967B (en) * | 2014-04-03 | 2016-10-05 | 张荣平 | Sanguis Draxonis compound recipe and the application in preparation treatment more wound medicine thereof |
| CN106109845A (en) * | 2016-05-05 | 2016-11-16 | 中国医学科学院药用植物研究所云南分所 | For treating the Sanguis Draxonis spray of pressure ulcer and inspection thereof and preparation method |
| CN106109845B (en) * | 2016-05-05 | 2019-07-26 | 中国医学科学院药用植物研究所云南分所 | For treating the Resina Draconis spray and its inspection and preparation method of pressure sore |
| CN108175822A (en) * | 2017-12-27 | 2018-06-19 | 广西中医药大学制药厂 | A kind of Resina Draconis spray-filming agent and preparation method thereof |
| CN108175822B (en) * | 2017-12-27 | 2020-12-15 | 广西中医药大学制药厂 | Dragon's blood film spraying agent and preparation method thereof |
| CN108014239A (en) * | 2017-12-28 | 2018-05-11 | 宁波高新区若水智创科技有限公司 | A kind of Chinese medicine preparation of wound hemostasis anti-inflammatory |
| CN108578540A (en) * | 2018-06-05 | 2018-09-28 | 深圳市旷逸生物科技有限公司 | A kind of biologic formulation and preparation method thereof for inhibiting scar and promoting wound healing |
| CN109893539A (en) * | 2019-03-26 | 2019-06-18 | 青岛九远医疗科技有限公司 | A kind of composite antibacterial aerosol and preparation method thereof |
| CN109893539B (en) * | 2019-03-26 | 2020-03-31 | 青岛九远医疗科技有限公司 | Composite antibacterial aerosol and preparation method thereof |
| CN112546290A (en) * | 2020-12-17 | 2021-03-26 | 江苏耐雀生物工程技术有限公司 | Antibacterial and anti-inflammatory liquid adhesive bandage and preparation method thereof |
| WO2022126628A1 (en) * | 2020-12-18 | 2022-06-23 | 江苏奇力康皮肤药业有限公司 | Liquid adhesive bandage and preparation method therefor |
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Application publication date: 20130710 |