CN104958230A - Functional oral care composition and application thereof - Google Patents
Functional oral care composition and application thereof Download PDFInfo
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- CN104958230A CN104958230A CN201510335474.6A CN201510335474A CN104958230A CN 104958230 A CN104958230 A CN 104958230A CN 201510335474 A CN201510335474 A CN 201510335474A CN 104958230 A CN104958230 A CN 104958230A
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Abstract
The invention relates to a functional oral care composition and application thereof. The functional oral care composition having functional components, lysozyme, Galla chinensis extract and licorice extract, has the effects of accelerating healing of oral ulcers and ruptured wounds, preventing dental decay and refreshing the breath. In order to facilitate using, the functional oral care composition can be made into common products, such as mouthwash, toothpaste, buccal tablets and oral film; the preparing process is simple and easy and lower in cost. The invention further provides the preparing process of mouthwash, toothpaste, buccal tablets and oral film made with the functional oral care composition.
Description
Technical field
The invention belongs to oral care product field, relate to a kind of functional oral care composition and application thereof.
Background technology
Oral ulcer (also known as scorching in aphtha, mouth) refers to the mucosa at the soft tissue places such as lip, tongue cheek and palate in oral cavity, occur single or multiple yellow-white circular or oval fester a little, on the feed, drink water, brush teeth when even speaking, touch ulcer place and all can feel obvious pain or burning sensation, the easy recurrent exerbation of some patient.Primary disease is one of modal disease in oral mucosa, common with person between twenty and fifty, and definite pathogenesis scorching in mouth it be unclear that.In oral cavity, physical trauma is scorching inducement in the most common mouth, such as by stabbing of causing of brush wear, sharp-pointed (such as chrips) or wear-resisting food (such as zwieback) or wear and tear, tooth stings (particularly common betide sharp-pointed canine tooth) by mistake, falls tooth, or tooth set etc. easily destroys mucosa in mouth and causes inflammation mouth in.Other paathogenic factor such as chemical burn or scald also can cause in mouth scorching.
Dental caries is mankind's commonly encountered diseases and frequently-occurring disease, and at China's Incidence of caries about 35% ~ 45%, child can up to about 70%.It not only destroys tissue of tooth, causes toothache, masticatory function goes down or lose, but also invades jawbone and cause periapical periodontitis, osteomyelitis etc., even becomes " chronic lesion ", has a strong impact on the Health and Living quality of body.
Lysozyme (lysozyme, Lyz) also known as muramidase, Lysozyme or N-acetylmuramide lycanohydrlase, be a kind of alkaline enzyme that can be hydrolyzed mucopolysaccharide in pathogenic bacterium, be extensively present in the tissue of higher mammal, saliva, tear, serum, lymph etc. and protozoacide, insecticide, plant and microorganism.It, mainly through the β-Isosorbide-5-Nitrae glycosidic bond between the-acetylmuramic acid in destruction cell wall and NAG, makes the insoluble mucopolysaccharide of cell wall resolve into solubility glycopeptide, causes cell wall rupture content overflow and make bacterolysis.Lysozyme also directly can be combined with electronegative virus protein, forms double salt, make virally inactivated with DNA, RNA, apoprotein.Because lysozyme is while the various antibacterial of dissolving, also can be combined with the various acidic materials bringing out human body inflammation, to its deactivation, also can increase the curative effect of antibiotic and other antibacterials simultaneously, thus reach antiinflammatory object, therefore it is used for the treatment of acute and chronic pharyngitis, oral ulcer, chickenpox, herpes zoster and verruca plana etc. clinically, treats various antibacterial and viral infection when share with antibacterials.Study display in addition, lysozyme in oral cavity participates in the adjustment process of homeostasis, with the generation of dental caries, diseases of oral mucosa and periodontal disease, develops and has certain relation.
Natural drug Galla Chinensis is that a kind of gall maker stabs Fructus rhois chinensis leaf and the insect gall generated, and has anastaltic effect.Studies in China shows, Galla Chinensis extract to the growth of some cariogenic bacterias, produce sugar, produce acid and inhibitory action is stained with to hydroxyapatite, have inhibitory action to the decomposition of carious dentin's collagen.Correlational study is pointed out, and uses Galla Chinensis extract as oral cavity medicine, several main cariogenic antibacterial is had to the effect suppressing its growing multiplication, and can not kill antibacterial comprehensively, thus effectively can maintain the microecological balance of oral cavity bacterium.Gallic main component is water-disintegrable gallotannic acid according to the literature, existing research confirms that gallotannic acid composition produces the activity of the key enzyme-glucosyltransferase of water-insoluble extracellular polysaccharide by anti-bacteria, in the early stage quantity that can reduce Adherent bacteria that bacterial plaque is formed, also remove from oral cavity by the mutual gathering between antibacterial.These effects of Gallotannin may be it and protein bound and make it to precipitate, caused by the convergence of namely tannin.
Radix Glycyrrhizae property is hidden sweet flat, is QI invigorating class Chinese medicine, has the merit of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, nourishing the lung to arrest cough, relieving spasm to stop pain, the mediation property of medicine.The main component of Radix Glycyrrhizae comprises glycyrrhizin, glycyrrhizic acid, enoxolone, liquiritin, flavonoids of Glycyrrhiza, formoononetin, Quercetin etc., and existing a lot of bibliographical information Radix Glycyrrhizae extract has removing toxic substances, antiinflammatory, antitussive, antitumor, antiulcer, the effect such as antibacterial.The 1950's, the research of Orland specify that Streptococcus mutans is the Main Pathogenic Bacteria of human caries, some studies in China find in recent years, Radix Glycyrrhizae extract obviously can suppress the growth and breeding of Streptococcus mutans, suppress formation and the Streptococcus mutans dextranase activity of bacterial plaque, reduce the generation of acid, suppress the generation of dental caries from the different phase of dental caries.
Along with the raising of people's living standard, oral hygiene and health are more and more subject to people's attention, and people have no longer been confined to sooner or later twice brush teeth, and the collutory being convenient to carry with has become the indispensable and fashion of one way of life.And rhythm of life quickening, operating pressure aggravation, bad life habits etc. also cause the day by day occurred frequently of the oral problem such as oral ulcer, dental caries, especially for the very fast city crowd of rhythm, cause certain puzzlement.The functional oral care composition of the one that the present invention relates to comprises lysozyme, Galla Chinensis extract and Radix Glycyrrhizae extract three kinds of functional components, collutory easy to use, toothpaste, buccal tablet and oral film can be prepared into, while promotion ulcer healing, caries prevention, all right fresh breath, nursing tooth, achieve many things at one stroke, there is certain economic benefit and social benefit.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art, there is provided that a kind of preparation technology is comparatively simple, the functional oral care composition of lower cost, it is characterized in that containing both effectiveness composition lysozyme, Galla Chinensis extract and Radix Glycyrrhizae extract, wherein the content of lysozyme is 0.005-0.01%, Galla Chinensis extract is 0.05-0.25%, and Radix Glycyrrhizae extract is 1-10%.
Second object of the present invention is to provide a kind of application of functional oral care composition, it can make common oral care implement, comprise collutory, toothpaste, buccal tablet and oral film, there is the effect accelerating oral ulcer and damaged wound healing, caries prevention, fresh breath.
The preparation method of the collutory that a kind of functional oral care composition that the present invention relates to is made is: take sodium hydrogen phosphate 499g, sodium dihydrogen phosphate 50g, the buffer soln being made into pH=7.4 by appropriate purified water is for subsequent use; By 1g lysozyme, 600g Radix Glycyrrhizae extract, 15g Galla Chinensis extract, after mixing with 500g Polyethylene Glycol, add buffer solution, then add 200g xylitol, 10g Mint Essence, 10g ethyl hydroxybenzoate, after stirring evenly, polishing solvent is to 10kg i.e. obtained collutory 100 bottles amount (100g/ bottle).
The preparation method of the toothpaste that a kind of functional oral care composition that the present invention relates to is made is: take sodium carboxymethyl cellulose 25g, glue is slowly swelled into for subsequent use with appropriate purified water mixing, take lysozyme 0.05g, Radix Glycyrrhizae extract 50g, Galla Chinensis extract 0.5g, calcium carbonate 1500g, sorbitol 200g, titanium dioxide 20g, glycyrrhizic acid dipotassium 50g, sodium lauryl sulphate 50g, add 300g glycerol to stir, slowly add glue ground and mixed even, until all add, rear placement 1h, add 10g minty note seminal fluid, (100 toothpaste recipe quantities) is got final product after stirring evenly.
The preparation method of the buccal tablet that a kind of functional oral care composition that the present invention relates to is made is: take lysozyme 0.015g, Radix Glycyrrhizae extract 15g, Galla Chinensis extract 0.38g, mix rear and 60g maltodextrin mixed in equal amounts, add 70g sorbitol, 2g polyvinylpolypyrrolidone again, sieve mix homogeneously, with 50% ethanol soft material, in 40 DEG C of dryings after granulation, granulate, after adding 1g essence, 1.5g magnesium stearate mix homogeneously, tabletting.Above-mentioned recipe quantity is 100 amounts, and the buccal tablet made is 150mg/ sheet.
The preparation method of the oral film that a kind of functional oral care composition that the present invention relates to is made is: take lysozyme 10g, Radix Glycyrrhizae extract 0.6g, Galla Chinensis extract 0.15g, stir evenly with the moistening of 10g glycerol, add 7g maltodextrin, 10g lactose, 22g hydroxypropyl cellulose, 140g purified water, be placed to completely swelling after stirring, add the refrigerant essence of 1g and stir evenly rear froth breaking, film, in 60 DEG C of dryings, the demoulding and get final product.Above-mentioned recipe quantity is 1000 amounts, and the oral film made is 60mg/ sheet.
Advantage of the present invention:
The functional oral care composition of the one that the present invention relates to, because it contains both effectiveness composition lysozyme, Galla Chinensis extract and Radix Glycyrrhizae extract, has the effect accelerating oral ulcer and damaged wound healing, caries prevention, fresh breath.For the ease of using, functional oral care composition of the present invention can be prepared into common collutory, toothpaste, buccal tablet and oral film, and preparation technology is simple and easy to do, and cost is lower.
Detailed description of the invention
The present invention is further elaborated by following examples, but scope of the present invention is not limited to these embodiments.So, under method prerequisite of the present invention, all the scope of protection of present invention is belonged to simple modifications of the present invention.
The specific embodiments that the functional oral care composition that the present invention relates to makes collutory is as follows, and recipe quantity is 100 bottles of amounts, and the collutory made is every bottle of 100g:
embodiment 1
Lysozyme 0.5g
Radix Glycyrrhizae extract 100g
Galla Chinensis extract 5g
Glycerol 500g
Sorbitol 200g
Mint Essence 10g
Sodium dihydrogen phosphate 54g
Sodium hydrogen phosphate 534g
Glycyrrhizic acid dipotassium 10g
Preparation technology: take sodium hydrogen phosphate, sodium dihydrogen phosphate, the buffer soln being made into pH=7.4 by appropriate purified water is for subsequent use; By lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, after mixing with glycerol, add buffer solution, then add sorbitol, Mint Essence, glycyrrhizic acid dipotassium, stir evenly rear polishing solvent to 10kg.
Evaluate: outward appearance is settled solution, good mouthfeel, and pH is about 7.0, meets the requirements of relevant GB.
embodiment 2
Lysozyme 0.8g
Radix Glycyrrhizae extract 300g
Galla Chinensis extract 10g
Propylene glycol 500g
Maltose alcohol 200g
Mint Essence 10g
Sodium dihydrogen phosphate 53g
Sodium hydrogen phosphate 522g
Cetylpyridinium chloride 1g
Preparation technology: take sodium hydrogen phosphate, sodium dihydrogen phosphate, the buffer soln being made into pH=7.4 by appropriate purified water is for subsequent use; By lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, after mixed with propylene glycol, add buffer solution, then add maltose alcohol, Mint Essence, cetylpyridinium chloride, stir evenly rear polishing solvent to 10kg.
Evaluate: outward appearance is settled solution, and mouthfeel is good, and pH is about 7.0, meets the requirements of relevant GB.
embodiment 3
Lysozyme 1g
Radix Glycyrrhizae extract 600g
Galla Chinensis extract 15g
Polyethylene Glycol 500g
Xylitol 200g
Mint Essence 10g
Sodium dihydrogen phosphate 50g
Sodium hydrogen phosphate 499g
Ethyl hydroxybenzoate 10g
Preparation technology: take sodium hydrogen phosphate, sodium dihydrogen phosphate, the buffer soln being made into pH=7.4 by appropriate purified water is for subsequent use; By lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, after mixing with Polyethylene Glycol, add buffer solution, then add xylitol, Mint Essence, ethyl hydroxybenzoate, stir evenly rear polishing solvent to 10kg.
Evaluate: outward appearance is settled solution, and mouthfeel is good, and pH is about 7.0, meets the requirements of relevant GB.
embodiment 4
Lysozyme 1g
Radix Glycyrrhizae extract 1000g
Galla Chinensis extract 25g
Polyethylene Glycol 500g
Xylitol 200g
Refrigerant essence 10g
Sodium dihydrogen phosphate 49g
Sodium hydrogen phosphate 481g
Ethyl hydroxybenzoate 10g
Preparation technology: take sodium hydrogen phosphate, sodium dihydrogen phosphate, the buffer soln being made into pH=7.4 by appropriate purified water is for subsequent use; By lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, after mixing with Polyethylene Glycol, add buffer solution, then add xylitol, refrigerant essence, ethyl hydroxybenzoate, stir evenly rear polishing solvent to 10kg.
Evaluate: outward appearance is settled solution, and mouthfeel is good, and pH is about 7.0, meets the requirements of relevant GB.
The specific embodiments that the functional oral care composition that the present invention relates to makes toothpaste is as follows, and recipe quantity is the consumption of 100 toothpaste:
embodiment 5
Lysozyme 0.05g
Radix Glycyrrhizae extract 50g
Galla Chinensis extract 0.5g
Calcium carbonate 1500g
Glycerol 300g
Sorbitol 200 g
Sodium carboxymethyl cellulose 25g
Minty note seminal fluid 10g
Titanium dioxide 20g
Glycyrrhizic acid dipotassium 50g
Sodium lauryl sulphate 50g
Preparation technology: take sodium carboxymethyl cellulose, glue is slowly swelled into for subsequent use with appropriate purified water mixing, take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, calcium carbonate, sorbitol, titanium dioxide, glycyrrhizic acid dipotassium, sodium lauryl sulphate, add glycerol to stir, slowly add glue ground and mixed even, until all add, rear placement 1h, add minty note seminal fluid, after stirring evenly.
Evaluate: the even foreign of mastic, good mouthfeel, meets the requirements of relevant GB.
embodiment 6
Lysozyme 0.08g
Radix Glycyrrhizae extract 150g
Galla Chinensis extract 1g
Calcium hydrogen phosphate 2000g
Propylene glycol 300g
Xylitol 200 g
Hydroxyethyl-cellulose 25g
Lilac compound 10g
Titanium dioxide 50g
Sodium benzoate 30g
Sodium N-lauroyl sarcosinate 80g
Preparation technology: take hydroxyethyl-cellulose, glue is slowly swelled into for subsequent use with appropriate purified water mixing, take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, calcium bicarbonate, xylitol, titanium dioxide, hydroxyethyl-cellulose, sodium benzoate, sodium lauroyl sarcosine, add propylene glycol to stir, slowly add glue ground and mixed even, until all add, rear placement 1h, add lilac compound, after stirring evenly.
Evaluate: the even foreign of mastic, good mouthfeel, meets the requirements of relevant GB.
embodiment 7
Lysozyme 0.1g
Radix Glycyrrhizae extract 300g
Galla Chinensis extract 1.5g
Calcium pyrophosphate 2500g
Macrogol 200 g
Mannitol 300 g
Sodium alginate 50g
Refrigerant essence 10g
Titanium dioxide 50g
Ethyl hydroxybenzoate 50g
Sodium lauryl sulphate 100g
Preparation technology: take sodium alginate, mix by appropriate purified water, slowly be swelled into glue for subsequent use, take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, calcium pyrophosphate, mannitol, titanium dioxide, ethyl hydroxybenzoate, sodium lauryl sulphate, add Polyethylene Glycol and stir, it is even slowly to add glue ground and mixed, until all add, rear placement 1h, adds refrigerant essence, after stirring evenly.
Evaluate: the even foreign of mastic, good mouthfeel, meets the requirements of relevant GB.
embodiment 8
Lysozyme 0.1g
Radix Glycyrrhizae extract 1000g
Galla Chinensis extract 2.5g
Hydrated silica 3000g
Glycerol 200g
Xylitol 300 g
Sodium alginate 50g
Refrigerant essence 10g
Titanium dioxide 50g
Sodium benzoate 50g
Sodium lauryl sulphate 100g
Preparation technology: take sodium alginate, mix by appropriate purified water, slowly be swelled into glue for subsequent use, take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, hydrated silica, xylitol, titanium dioxide, sodium benzoate, sodium lauryl sulphate, add glycerol and stir, it is even slowly to add glue ground and mixed, until all add, rear placement 1h, adds refrigerant essence, after stirring evenly.
Evaluate: the even foreign of mastic, good mouthfeel, meets the requirements of relevant GB.
The specific embodiments that the functional oral care composition that the present invention relates to makes buccal tablet is as follows:
embodiment 9
Lysozyme 0.005g
Radix Glycyrrhizae extract 1.0g
Galla Chinensis extract 0.05g
Glucose 54g
Starch 10g
Sucrose 32g
Carboxymethyl starch sodium 2g
Mint Essence 0.5g
Magnesium stearate 1g
Above-mentioned recipe quantity is 1000 amounts, and the buccal tablet made is 100mg/ sheet.
Preparation technology: take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, mix rear and glucose mixed in equal amounts, add starch, sucrose, carboxymethyl starch sodium again, sieve mix homogeneously, with appropriate 30% ethanol soft material, in 40 DEG C of dryings after granulation, granulate, after adding Mint Essence, magnesium stearate mix homogeneously, tabletting.
Evaluate: smooth appearance, mouthfeel is better.Detect according to the quality standard drafted voluntarily, indices all meets the requirements.
embodiment 10
Lysozyme 0.01g
Radix Glycyrrhizae extract 3.6g
Galla Chinensis extract 0.12g
Maltodextrin 47g
Starch 15g
Sorbitol 50g
Cross-linking sodium carboxymethyl cellulose 2g
Essence 0.5g
Magnesium stearate 1.5g
Above-mentioned recipe quantity is 100 amounts, and the buccal tablet made is 120mg/ sheet.
Preparation technology: take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, mix rear and sorbitol mixed in equal amounts, add starch, maltodextrin, cross-linking sodium carboxymethyl cellulose again, sieve mix homogeneously, with 50% ethanol soft material, in 40 DEG C of dryings after granulation, granulate, after adding essence, magnesium stearate mix homogeneously, tabletting.
Evaluate: smooth appearance, mouthfeel is better.Detect according to the quality standard drafted voluntarily, indices all meets the requirements.
embodiment 11
Lysozyme 0.012g
Radix Glycyrrhizae extract 7.2g
Galla Chinensis extract 0.18g
Mannitol 48 g
Lactose 60g
Low-substituted hydroxypropyl cellulose 2g
Essence 1g
Magnesium stearate 1.5g
Above-mentioned recipe quantity is 100 amounts, and the buccal tablet made is 120mg/ sheet.
Preparation technology: take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, mix rear and lactose mixed in equal amounts, add mannitol, low-substituted hydroxypropyl cellulose again, sieve mix homogeneously, with 70% ethanol soft material, in 40 DEG C of dryings after granulation, granulate, after adding essence, magnesium stearate mix homogeneously, tabletting.
Evaluate: smooth appearance, mouthfeel is better.Detect according to the quality standard drafted voluntarily, indices all meets the requirements.
embodiment 12
Lysozyme 0.015g
Radix Glycyrrhizae extract 15g
Galla Chinensis extract 0.38g
Sorbitol 70g
Maltodextrin 60g
Polyvinylpolypyrrolidone 2g
Essence 1g
Magnesium stearate 1.5g
Above-mentioned recipe quantity is 100 amounts, and the buccal tablet made is 150mg/ sheet.
Preparation technology: take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, mix rear and maltodextrin mixed in equal amounts, add sorbitol, polyvinylpolypyrrolidone again, sieve mix homogeneously, with 50% ethanol soft material, in 40 DEG C of dryings after granulation, granulate, after adding essence, magnesium stearate mix homogeneously, tabletting.
Evaluate: smooth appearance, mouthfeel is better.Detect according to the quality standard drafted voluntarily, indices all meets the requirements.
The specific embodiments that the functional oral care composition that the present invention relates to makes oral film is as follows:
embodiment 13
Lysozyme 5g
Radix Glycyrrhizae extract 0.3g
Galla Chinensis extract 0.015g
Propylene glycol 5g
Glucose 5g
Pregelatinized Starch 5g
Hydroxypropyl methylcellulose 12g
Mint Essence 1g
Purified water 120g
Above-mentioned recipe quantity is 1000 amounts, and the oral film made is 30mg/ sheet.
Preparation technology: take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, stir evenly with propylene glycol moistening, add glucose, pregelatinized Starch, hydroxypropyl methylcellulose, purified water, be placed to completely swelling after stirring, add Mint Essence and stir evenly rear froth breaking, film, in 60 DEG C of dryings, the demoulding and get final product.
Evaluate: appearance uniform, flexible, mouthfeel is better.Detect according to the quality standard drafted voluntarily, indices all meets the requirements.
embodiment 14
Lysozyme 8g
Radix Glycyrrhizae extract 1.2g
Galla Chinensis extract 0.04g
Polyethylene Glycol 6g
Microcrystalline Cellulose 8g
IR 15g
Mannitol 8g
Refrigerant essence 1g
Purified water 120g
Above-mentioned recipe quantity is 1000 amounts, and the oral film made is 40mg/ sheet.
Preparation technology: take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, stir evenly with Polyethylene Glycol moistening, add microcrystalline Cellulose, IR, mannitol, purified water, be placed to completely swelling after stirring, add refrigerant essence and stir evenly rear froth breaking, film, in 60 DEG C of dryings, the demoulding and get final product.
Evaluate: appearance uniform, flexible, mouthfeel is better.Detect according to the quality standard drafted voluntarily, indices all meets the requirements.
embodiment 15
Lysozyme 10g
Radix Glycyrrhizae extract 0.3g
Galla Chinensis extract 0.075g
Glycerol 10g
Sorbitol 7g
Sodium carboxymethyl cellulose 2g
Polyvidone 20g
Mint Essence 1g
Purified water 130g
Above-mentioned recipe quantity is 1000 amounts, and the oral film made is 50mg/ sheet.
Preparation technology: take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, stirs evenly with glycerol moistening, adds sorbitol, polyvidone, sodium carboxymethyl cellulose, purified water, place completely swelling after stirring, add Mint Essence and stir evenly, froth breaking, film, in 60 DEG C of dryings, the demoulding and get final product.
Evaluate: appearance uniform, flexible, mouthfeel is better.Detect according to the quality standard drafted voluntarily, indices all meets the requirements.
embodiment 16
Lysozyme 10g
Radix Glycyrrhizae extract 0.6g
Galla Chinensis extract 0.15g
Glycerol 10g
Maltodextrin 7g
Hydroxypropyl cellulose 22g
Lactose 10g
Refrigerant essence 1g
Purified water 140g
Above-mentioned recipe quantity is 1000 amounts, and the oral film made is 60mg/ sheet.
Preparation technology: take lysozyme, Radix Glycyrrhizae extract, Galla Chinensis extract, stir evenly with glycerol moistening, add maltodextrin, lactose, hydroxypropyl cellulose, purified water, be placed to completely swelling after stirring, add refrigerant essence and stir evenly rear froth breaking, film, in 60 DEG C of dryings, the demoulding and get final product.
Evaluate: appearance uniform, flexible, mouthfeel is better.Detect according to the quality standard drafted voluntarily, indices all meets the requirements.
The both effectiveness result of the test of functional oral care composition:
The result on trial of the collutory that the functional oral care composition that 1, the present invention relates to is made
Select 40 volunteers suffering from oral ulcer to try out, be divided into four groups at random, often organize 10 people, use in embodiment 1-4 the collutory prepared respectively, every day rinsing the mouth more than 3 times, each rinsing the mouth at least 1 minute, uses 5-10 days according to effect.
Criterion of therapeutical effect is: healing-ulcer is cured completely, and pain disappears; Improvement-ulcer surface reduces or ulcer reduces, pain relief; Invalid-ulcer does not heal, and pain exists.The therapeutic outcome of each group is in table 1.
The effect of the collutory that the routine volunteer of table 1 40 uses embodiment 1-4 to make
Whole volunteer represents in the process using collutory, feels good, non-stimulated or uncomfortable sensation.
The bacteriostatic test of the toothpaste that the functional oral care composition that 2, the present invention relates to is made
(1) toothpaste prepared by embodiment 5-8 and sterilized water 1:3 are diluted to after homogeneous toothpaste starches, and get the aseptic and filter paper of drying, every sheet drips dentifrice slurry 20 μ l, is then lain against in cleaning sterile plate by filter paper, uncap to put in baking oven 37 DEG C and dry.Arrange one group of ordinary toothpaste to contrast.
(2) test strain is porphyromonas gingivalis bacteria suspension, Streptococcus mutans bacteria suspension, Prevotella intermedia bacteria suspension and Fusobacterium nucleatum bacteria suspension.Test organisms inoculation and antibacterial print are placed with reference to " disinfection technology standard (version in 2002) ".
(3) measure collarium, select bacterial restrain that is even and integral asepsis growth to measure, the results are shown in Table 2.Inhibition zone diameter >=7mm is for having fungistatic effect, and≤7mm is without fungistatic effect.
The toothpaste that table 2 embodiment 5-8 makes is to oral cavity common pathogen inhibition
The suppression plaque assay of the buccal tablet that the functional oral care composition that 3, the present invention relates to is made
Select denture polishing, marshalling, within tested first 3 months, do not use antibiotic students 50 (boy student 20, schoolgirl 30) as volunteer, be divided into 5 groups at random, often organize 10 people, 1-4 group is test group, take the buccal tablet that embodiment 9-12 makes respectively, 5 groups is negative control group, takes blank.Usage and dosage is containing changing in mouth, each 2, once a day.Clean one's teeth before subject per's test, bacterial plaque of tooth surface index is made to reduce to zero, take medicine after cleaning one's teeth, stop brushing teeth 24h, respectively at after taking medicine 4,24h basic fuchsin dyes, adopt Qingley-Hein method record 16,21,24,36,41,44 tooth position plaque index, recover to brush teeth, use same method inspection respectively every 2 weeks later, continue 8 weeks altogether.The results are shown in Table 3.Compared with 5 groups that take blank, the suppression bacterial plaque difference on effect of 1-4 group has significance.
The suppression bacterial plaque effect of the buccal tablet that table 3 embodiment 9-12 makes
The result on trial of the oral film that the functional oral care composition that 4, the present invention relates to is made
Select 60 volunteers suffering from oral ulcer to try out, be divided into four groups at random, often organize 15 people, use the oral film prepared in embodiment 13-16 respectively, be affixed on affected part, every 6-8h once, uses 3-4 sheet every day, uses 5-10 days according to effect.
Criterion of therapeutical effect is: healing-ulcer is cured completely, and pain disappears; Improvement-ulcer surface reduces or ulcer reduces, pain relief; Invalid-ulcer does not heal, and pain exists.The therapeutic outcome of each group is in table 4.Whole volunteer represents in the process using oral film, feels good, non-stimulated or uncomfortable sensation.
The effect of the oral film that the routine volunteer of table 4 60 uses embodiment 13-16 to make
Claims (6)
1. a functional oral care composition and application thereof, it is characterized in that described functional oral care composition contains both effectiveness composition lysozyme, Galla Chinensis extract and Radix Glycyrrhizae extract, wherein the content of lysozyme is 0.005-0.01%, Galla Chinensis extract is 0.05-0.25%, and Radix Glycyrrhizae extract is 1-10%.
2. the functional oral care composition of one according to claim 1 and application thereof, it is characterized in that described functional oral care composition can make common oral care implement, comprise collutory, toothpaste, buccal tablet and oral film etc., there is the effect accelerating oral ulcer and damaged wound healing, caries prevention, fresh breath.
3. the functional oral care composition of one according to claim 1 and application thereof, it is characterized in that the preparation method of the collutory that described functional oral care composition is made is: take sodium hydrogen phosphate 499g, sodium dihydrogen phosphate 50g, the buffer soln being made into pH=7.4 by appropriate purified water is for subsequent use; By 1g lysozyme, 600g Radix Glycyrrhizae extract, 15g Galla Chinensis extract, after mixing with 500g Polyethylene Glycol, add buffer solution, add 200g xylitol, 10g Mint Essence, 10g ethyl hydroxybenzoate again, after stirring evenly, polishing solvent, to 10kg, namely obtains collutory 100 bottles amount (100g/ bottle).
4. the functional oral care composition of one according to claim 1 and application thereof, it is characterized in that the preparation method of the toothpaste that described functional oral care composition is made is: take sodium carboxymethyl cellulose 25g, be slowly swelled into glue with appropriate purified water mixing for subsequent use; Take lysozyme 0.05g, Radix Glycyrrhizae extract 50g, Galla Chinensis extract 0.5g, calcium carbonate 1500g, sorbitol 200g, titanium dioxide 20g, glycyrrhizic acid dipotassium 50g, sodium lauryl sulphate 50g, add 300g glycerol to stir, slowly add glue ground and mixed even, until all add, rear placement 1h, add 10g minty note seminal fluid, after stirring evenly, get final product (100 toothpaste recipe quantities).
5. the functional oral care composition of one according to claim 1 and application thereof, it is characterized in that the preparation method of the buccal tablet that described functional oral care composition is made is: take lysozyme 0.015g, Radix Glycyrrhizae extract 15g, Galla Chinensis extract 0.38g, mix rear and 60g maltodextrin mixed in equal amounts, add 70g sorbitol, 2g polyvinylpolypyrrolidone again, sieve mix homogeneously, with 50% ethanol soft material, in 40 DEG C of dryings after granulation, granulate, after adding 1g essence, 1.5g magnesium stearate mix homogeneously, tabletting; Above-mentioned recipe quantity is 100 amounts, and the buccal tablet made is 150mg/ sheet.
6. the functional oral care composition of one according to claim 1 and application thereof, it is characterized in that the preparation method of the oral film that described functional oral care composition is made is: take lysozyme 10g, Radix Glycyrrhizae extract 0.6g, Galla Chinensis extract 0.15g, stir evenly with the moistening of 10g glycerol, add 7g maltodextrin, 10g lactose, 22g hydroxypropyl cellulose, 140g purified water, be placed to completely swelling after stirring, add the refrigerant essence of 1g and stir evenly rear froth breaking, film, in 60 DEG C of dryings, the demoulding and get final product; Above-mentioned recipe quantity is 1000 amounts, and the oral film made is 60mg/ sheet.
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| CN106420396A (en) * | 2016-10-19 | 2017-02-22 | 安徽克菱保健科技有限公司 | Enzyme-containing double-layer mouth-washing tablet |
| CN110235799A (en) * | 2019-07-23 | 2019-09-17 | 北京百林康源生物技术有限责任公司 | A kind of High-efficiency anti-bacterial dog chew containing enzyme and preparation method thereof |
| CN110237241A (en) * | 2019-07-05 | 2019-09-17 | 广州康云生物科技有限公司 | A kind of compositions of additives containing lysozyme and plant extracts |
| CN110251664A (en) * | 2019-07-05 | 2019-09-20 | 广州康云生物科技有限公司 | A kind of oral nursing liquid containing lysozyme and plant extracts |
| CN110279609A (en) * | 2019-07-05 | 2019-09-27 | 广州康云生物科技有限公司 | A kind of toothpaste containing lysozyme and plant extracts |
| CN113144177A (en) * | 2021-02-19 | 2021-07-23 | 山东莱博生物科技有限公司 | Surface sterilization antiviral spray and preparation method and application thereof |
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| CN113144177A (en) * | 2021-02-19 | 2021-07-23 | 山东莱博生物科技有限公司 | Surface sterilization antiviral spray and preparation method and application thereof |
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