CN110279609A - A kind of toothpaste containing lysozyme and plant extracts - Google Patents
A kind of toothpaste containing lysozyme and plant extracts Download PDFInfo
- Publication number
- CN110279609A CN110279609A CN201910602890.6A CN201910602890A CN110279609A CN 110279609 A CN110279609 A CN 110279609A CN 201910602890 A CN201910602890 A CN 201910602890A CN 110279609 A CN110279609 A CN 110279609A
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- Prior art keywords
- plant extracts
- lysozyme
- extract
- toothpaste
- root extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses a kind of toothpaste containing lysozyme and plant extracts.The toothpaste contains a kind of compositions of additives being made of lysozyme and plant extracts；The plant extracts is one of Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract or a variety of.The present invention is by one of lysozyme and above-mentioned plant extracts or a variety of compound uses, on the one hand it solves and be easy to cause oral bacteria ecological disturbance commonly using the oral care product of chemical component, make it is bacterial resistance occurred, cannot achieve the effect that prevent mouth disease the problem of；On the other hand, the lysozyme deficiency weaker to Gram-negative bacteria sterilizing ability is compensated for, while compensating for the deficiency for being applied alone plant extracts Antifungal activity weak, makes the compositions of additives containing lysozyme and plant extracts that there is good wide spectrum to press down bactericidal effect.
Description
Technical field
The present invention relates to lysozyme applied technical fields, and in particular, to a kind of containing lysozyme and plant extracts
Toothpaste.
Background technique
Oral problem mainly as caused by bacterium, is arranged using effective toothpaste, gargle and oral disease therapeutic etc.
The quantity that can be substantially reduced pathogenic bacteria in oral cavity is applied, improvement even is eliminated mouth disease.The oral cavities such as toothpaste, oral nursing liquid shield
It is mainly the active constituent or antipathogenic composition leaned in product why reason product, which is able to achieve these functions, these antipathogenic compositions are mostly
Chemical classes bacteriostatic agent (such as triclosan, Cetylpyridinium Chloride, chlorohexidene, antibiotic) is protected commonly using the oral cavity containing these ingredients
Reason product be easy to cause Oral health behaviours to lack of proper care, or make it is bacterial resistance occurred, cannot achieve the effect that prevent mouth disease, instead
And cause other multiple oral diseases.
Lysozyme (Lysozyme) is the non-specific material composition of one of saliva, can be suppressed growth of microorganism, with
Antibiotic or the comparison of other antibacterial substances, it is not in drug resistance that lysozyme, which is used for a long time,.Lysozyme can effectively hydrolytic bacteria
The peptide glycan of cell wall, hydrolytic sites are 1 carbon atom and N-Acetyl-D-glucosamine (NAG) of -acetylmuramic acid (NAM)
4 carbon atoms between β -1,4 glycosidic bond.Peptide glycan is the main ingredient of bacteria cell wall, it is by NAM, NAG and peptide " tail "
(usually 4 amino acid) composition, NAM are connected with NAG by β-Isosorbide-5-Nitrae glycosidic bond, and peptide " tail " is connected by D- lactoyl carboxyl
On the 3rd carbon atom of NAM, connected between peptide tail by peptide " bridge " (peptide bond or a few amino acid), NAM, NAG, peptide
" tail " and peptide " bridge " has collectively constituted the multilayer network structure of peptide glycan, any in above structure as the skeleton of cell wall
Chemical bond rupture can all lead to the damage of bacteria cell wall.For gram-positive bacteria (G+), such as staphylococcus aureus, withered
Straw bacterium or micrococcus lysodeikticus etc., with Gram-negative bacteria (G-), as Escherichia coli, Fusobacterium nucleatum, porphyromonas gingivalis,
Pneumobacillus etc., peptidoglycan content is different in cell wall.G+Bacteria cell wall almost all is made of peptide glycan, and G-Bacterium
Only inner wall layer is peptide glycan, and therefore, lysozyme is to G+Bacterium, which has to press down well, kills effect, but to compared with G-The antibacterial work of bacterium
With weaker.
Plant extracts, which refers to, to be present in plant, and people have life by what the method for physics or chemistry extracted
The active substance of object, effective component such as alkaloid, volatile oil, flavones, polysaccharide, organic acid, tannin, grease etc. all have difference
The antibacterial action of degree.But the Antifungal activity of most plants extract is relatively low, and fungistatic effect is unobvious when low dose uses, greatly
In the presence of the quality for influencing food when dosage uses, such as the problems such as mouthfeel, color, smell.It has had not yet to see lysozyme and has planted
Object extract compounds the relevant report for inhibiting oral bacteria.
Summary of the invention
The purpose of the invention is to overcome the above-mentioned deficiency of the prior art, one kind is provided and contains lysozyme and plant extract
The toothpaste of object.
Another object of the present invention is to provide the preparation methods of above-mentioned toothpaste.
To achieve the goals above, the present invention is achieved by following scheme:
A kind of toothpaste containing lysozyme and plant extracts, the toothpaste contain one kind by lysozyme and plant extracts
The compositions of additives of composition；The plant extracts is Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea
One of leaf extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract are a variety of.
On the one hand the present invention is by solving one of lysozyme and above-mentioned plant extracts or a variety of compound uses
Be easy to cause oral bacteria ecological disturbance commonly using the oral care product of chemical component, make it is bacterial resistance occurred, cannot
Achieve the effect that the problem of preventing mouth disease；On the other hand, significant synergy is produced, it is blue to leather to compensate for lysozyme
The weaker deficiency of family name's negative bacterium sterilizing ability, while the deficiency for being applied alone plant extracts Antifungal activity weak is compensated for, make containing molten
There is the compositions of additives of bacterium enzyme and plant extracts good wide spectrum to press down bactericidal effect.
Preferably, when plant extracts is a kind of, the mass ratio of the lysozyme and plant extracts be (0.01~
10): (0.1~10)；
When plant extracts is two kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10):
(0.1~10): (0.1~10)；
When plant extracts is three kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10):
(0.1~10): (0.1~10): (0.1~10)；
When plant extracts is four kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10):
(0.1~10): (0.1~10): (0.1~10): (0.1~10)；
When plant extracts is five kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10):
(0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10)；
When plant extracts is six kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10):
(0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10)；
When plant extracts is seven kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10):
(0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10).
It is highly preferred that when plant extracts is Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tealeaves mention
When taking object, glycyrrhiza glabra root extract, german chamomile flower extract, any in rosemary leaf extract, the lysozyme and plant
The mass ratio of object extract is 1:2.
It is highly preferred that when plant extracts is Gotu Kola P.E and polygonum cuspidate root extract, the lysozyme and each plant
The mass ratio of object extract is 1:1:1.
It is highly preferred that when plant extracts is Gotu Kola P.E, polygonum cuspidate root extract and radix scutellariae root extract, it is described
The mass ratio of lysozyme and each plant extracts is 1:0.66:0.66:0.66.
It is highly preferred that when plant extracts is that Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract and tealeaves mention
When taking object, the mass ratio of the lysozyme and each plant extracts is 1:0.5:0.5:0.5:0.5.
It is highly preferred that when plant extracts is Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tealeaves mention
When taking object and glycyrrhiza glabra root extract, the mass ratio of the lysozyme and each plant extracts is 1:0.4:0.4:0.4:0.4:
0.4。
It is highly preferred that when plant extracts is Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tealeaves mention
When taking object, glycyrrhiza glabra root extract and german chamomile flower extract, the mass ratio of the lysozyme and each plant extracts is 1:
0.33:0.33:0.33:0.33:0.33:0.33.
It is highly preferred that when plant extracts is Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tealeaves mention
When taking object, glycyrrhiza glabra root extract, german chamomile flower extract and rosemary leaf extract, the lysozyme and each plant extracts
Mass ratio be 1:0.17:0.17:0.5:0.17:0.5:0.17:0.33.
Preferably, the toothpaste is grouped as by each group of following weight percent: moisturizer 10~50%, and rubbing agent 10~
40%, adhesive 0.1~3%, foaming agent 1~6%, essence 0.1~3%, sweetener 0.01~1%, lysozyme 0.01~
10%, plant extracts 0.1~10%, excess water.
It is highly preferred that the toothpaste is grouped as by each group of following weight percent: moisturizer 35~45%, rubbing agent 20
~35%, adhesive 1~2%, foaming agent 2~4%, essence 0.1~3%, sweetener 0.1~0.5%, lysozyme 0.01~
5%, plant extracts 0.1~10%, excess water.
Preferably, the moisturizer is one of sorbierite, polyethylene glycol, propylene glycol, glycerol or a variety of.
Preferably, the rubbing agent is one of silica, calcium carbonate, calcium monohydrogen phosphate, aluminium hydroxide or a variety of.
Preferably, described adhesive is one of sodium carboxymethylcellulose, xanthan gum, carragheen or a variety of.
Preferably, the foaming agent be lauryl sodium sulfate, sodium lauroyl sarcosine, Cocoamidopropyl betaine,
One of alkyl glycosides is a variety of.
Enforceable concrete scheme as one preferred, the toothpaste are grouped as by each group of following weight percent:
Sorbierite 42%, polyethylene glycol 2%, glycerol 1%, silica 20%, calcium carbonate 6%, calcium monohydrogen phosphate 4%, aluminium hydroxide
4%, sodium carboxymethylcellulose 0.5%, xanthan gum 0.4%, carragheen 0.2%, lauryl sodium sulfate 2%, lauroyl flesh ammonia
Sour sodium 1%, saccharin sodium 0.1%, Sucralose 0.1%, essence 1.2%, lysozyme 1%, Gotu Kola P.E 0.17%, polygonum cuspidate
Root extract 0.17%, radix scutellariae root extract 0.5%, tea extract 0.17%, glycyrrhiza glabra root extract 0.5%, german chamomile
Flower extract 0.17%, rosemary leaf extract 0.33%, excess water.
The preparation method of above-mentioned toothpaste is also claimed in the present invention, includes the following steps: to be proportionally added into moisturizer, friction
After agent, adhesive, water, foaming agent, sweetener, keeps vacuum degree in -0.090Mpa~-0.096Mpa, stir 20~50min；
Then essence, lysozyme, plant extracts is added, keeps vacuum degree in -0.090Mpa~-0.096Mpa, stirring 10~
Lotion is made in 50min.
Compared with prior art, the invention has the following advantages:
(1) present invention by lysozyme and Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea extract,
One of glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract or a variety of combined uses solve often
It is be easy to cause oral bacteria ecological disturbance using the oral care product of chemical component, makes bacterial resistance occurred, cannot be reached
The problem of preventing the effect of mouth disease.
(2) it is used in combination, is produced significant using one of plant extracts of the present invention or a variety of and lysozyme
Synergy, compensate for the lysozyme deficiency weaker to Gram-negative bacteria sterilizing ability, while compensating for and plant is applied alone to mention
The deficiency for taking object Antifungal activity weak makes the compositions of additives containing lysozyme and plant extracts that there is the suppression of good wide spectrum to kill
Bacterium effect.
(3) it is made into toothpaste using the compositions of additives containing lysozyme and plant extracts, gained toothpaste has good
Wide spectrum press down bactericidal effect, and then achieve the purpose that inhibit oral bacteria breed, while have treatment gingivitis and gum go out
The effect of blood.
Specific embodiment
The present invention is made combined with specific embodiments below and further being elaborated, the embodiment is served only for explaining this
Invention, is not intended to limit the scope of the present invention.Test method as used in the following examples is normal unless otherwise specified
Rule method；Used material, reagent etc., unless otherwise specified, for the reagent and material commercially obtained.
Embodiment 1
One kind containing lysozyme and plant extracts (Gotu Kola P.E, polygonum cuspidate root extract, radix scutellariae root extract, tea
One of leaf extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract are a variety of) compound,
According to the evaluation method of QB 2738-2012 daily chemical products antibacterial bacteriostatic effect, compositions of additives or raw material monomer object pair are measured
Common pathogen Streptococcus mutans (G in oral cavity-), porphyromonas gingivalis (G-), staphylococcus aureus (G+), Escherichia coli
(G-) inhibiting effect.
1, the fungistatic effect of raw material monomer is studied, formula is any one formula in the formula 1~11 in table 1.
The composition and fungistatic effect of the formula of table 1 1~11
As can be seen from Table 1, lysozyme kills effect than Gram-negative bacteria to the suppression of gram-positive bacteria and gets well, and
And the concentration of lysozyme has just had relatively better effect when reaching 1%；7 Plant Extracts have one at antibacterial aspect
Determine broad-spectrum antibacterial effect, but even if effect is also less desirable when reaching 2% concentration.
2, the fungistatic effect of the compound of lysozyme and single plant extracts is studied, formula is the formula 12 in table 2
Any one in~18 is formulated.
The composition and fungistatic effect of the formula of table 2 12~18
| Material name and bacteriostasis rate | Formula 12 | Formula 13 | Formula 14 | Formula 15 | Formula 16 | Formula 17 | Formula 18 |
| Lysozyme/% | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Gotu Kola P.E/% | 2 | / | / | / | / | / | / |
| Polygonum cuspidate root extract/% | / | 2 | / | / | / | / | / |
| Radix scutellariae root extract/% | / | / | 2 | / | / | / | / |
| Tea extract/% | / | / | / | 2 | / | / | / |
| Glycyrrhiza glabra root extract/% | / | / | / | / | 2 | / | / |
| German chamomile flower extract/% | / | / | / | / | / | 2 | / |
| Rosemary leaf extract/% | / | / | / | / | / | / | 2 |
| Water/% | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus |
| Streptococcus mutans bacteriostasis rate/% | 81.34 | 82.77 | 84.32 | 80.32 | 83.43 | 79.34 | 83.12 |
| Porphyromonas gingivalis bacteriostasis rate/% | 78.43 | 81.34 | 84.42 | 81.74 | 84.35 | 78.34 | 82.89 |
| Staphylococcus aureus bacteriostasis rate/% | 90.43 | 91.45 | 94.43 | 91.46 | 93.31 | 90.43 | 93.91 |
| Escherichia coli bacteriostasis rate/% | 79.32 | 81.54 | 85.14 | 80.83 | 83.67 | 81.23 | 84.97 |
As can be seen from Table 2: antibacterial effect when after (1) lysozyme and single plant extracts compounding than raw material monomer
Fruit will get well, lysozyme and plant extracts it is compound after have cooperative synergism effect and influence each other without product and lead to the activity of enzyme
The case where failure and the failure of plant extracts activity；(2) fungistatic effect of lysozyme+radix scutellariae root extract compound is compared with other
Compound to get well, followed by lysozyme+glycyrrhiza glabra root extract compound, lysozyme+rosemary leaf extract are answered
Closing object also has preferable fungistatic effect.
3, the fungistatic effect of the compound of lysozyme and multiple plant extracts is studied, formula is the formula 19 in table 3
Any one in~25 is formulated.
The composition and fungistatic effect of the formula of table 3 19~25
As can be seen from Table 3, in the case where lysozyme and plant extracts equivalent add, the bacteriostasis rate of compound
As the type that plant extracts adds is more, fungistatic effect is better, when reaching+seven Plant Extracts of lysozyme while adding
When, compound bacteriostasis rate reaches highest.
4, the fungistatic effect of the compound of the different proportion of lysozyme and seven Plant Extracts is studied, each formula wraps
+ seven Plant Extracts of lysozyme, wherein bacteriolyze enzyme dosage is fixed as 1%, and total dosage of seven Plant Extracts is
2%, but the ratio in each formula between seven Plant Extracts is different, and specific formula is shown in Table the formula 26~32 in 4.
The composition and fungistatic effect of the formula of table 4 26~32
As can be seen from Table 4, in the case where it is 1% that lysozyme, which is fixed on dosage, seven Plant Extracts are different
Different fungistatic effects is had when ratio, it can be seen from the results above that formula 30 (Gotu Kola P.E: polygonum cuspidate root extract:
Radix scutellariae root extract: tea extract: glycyrrhiza glabra root extract: german chamomile flower extract: rosemary leaf extract=1:1:3:
1:3:1:2) there is a best bacteriostasis, be followed by formulated 27 (Gotu Kola P.E: polygonum cuspidate root extract: radix scutellariae root extract:
Tea extract: glycyrrhiza glabra root extract: german chamomile flower extract: rosemary leaf extract=1:1:2:1:2:1:2) also have compared with
Good bacteriostasis.
Embodiment 2
According to embodiment 1 as a result, the compound of+seven Plant Extracts of lysozyme is applied in toothpaste.
A kind of toothpaste of the compositions of additives containing lysozyme and plant extracts, the specific formula of toothpaste are shown in Table 5 and match
Side 33~39.
Preparation process is as follows:
Moisturizer (sorbierite, polyethylene glycol, propylene glycol, glycerol), rubbing agent (silica, calcium carbonate, phosphoric acid hydrogen is added
Calcium, aluminium hydroxide), adhesive (sodium carboxymethylcellulose, xanthan gum, carragheen), water, foaming agent (lauryl sodium sulfate, the moon
Osmanthus acylsarcosine sodium, Cocoamidopropyl betaine), after sweetener (saccharin sodium, Sucralose), keep vacuum degree-
0.090Mpa~-0.096Mpa stirs 20~50min；Then edible essence, lysozyme, plant extracts is added (in seven kinds
It is one or more of), it keeps vacuum degree in -0.090Mpa~-0.096Mpa, stirs 10~50min, lotion is made.
According to the evaluation method of QB 2738-2012 daily chemical products antibacterial bacteriostatic effect, measurement 33~39 gained toothpaste of formula
To Streptococcus mutans, porphyromonas gingivalis, staphylococcus aureus, Escherichia coli inhibiting effect.Measurement result such as 5 institute of table
Show.
The composition and fungistatic effect of the formula of table 5 33~39
As can be seen from Table 5: (1) being made into using the lysozyme of raw material monomer, Gotu Kola P.E, radix scutellariae root extract
Lotion, fungistatic effect are not satisfactory, wherein monomer lysozyme enzyme is slightly good, and to gram-positive bacteria golden yellow grape
Coccus has preferable inhibitory or killing effect, slightly poor to Gram-negative bacteria inhibitory or killing effect, and the Gotu Kola P.E of monomer, scutellariae,radix mention
Take object totality fungistatic effect low compared with monomer lysozyme；(2) cream being made into using the compound of lysozyme compound botanical extract
Body, compared with to get well using raw material monomer lysozyme and plant extracts, fungistatic effect arranges suitable fungistatic effect from big to small
Sequence is+two Plant Extracts of+three Plant Extracts > lysozyme of+seven Plant Extracts > lysozyme of lysozyme, wherein
When bacteriolyze enzyme dosage is 1%, the ratio between seven Plant Extracts is Gotu Kola P.E: polygonum cuspidate root extract: scutellariae,radix is mentioned
Take object: tea extract: glycyrrhiza glabra root extract: german chamomile flower extract: rosemary leaf extract=1:1:3:1:3:1:2
When, lotion has best bacteriostasis.This illustrates there is synergistic effect in toothpaste after lysozyme and plant extracts are compound
Fruit, and lead to active the case where the failing with plant extracts activity of failing of enzyme without generating to influence each other.
33~39 gained toothpaste of formula are placed 45 DEG C 3 months, using fragrance, pH, lotion character as inspection target, as a result 3
It is normal that it is formulated 33~39 gained toothpaste stability after a month, illustrates that lysozyme and plant extracts do not have lotion formulation stability
Have an impact.
39 gained toothpaste of formula are subjected to treatment gingivitis and bleeding gums clinical test in 3 months by a definite date, use tooth
Gum index (gingival index, GI), spy examine bleeding percentage (percentage of bleeding on probing,
BOP% the index for) evaluating gingivitis and bleeding gums, when off-test, test group gingivitis and bleeding gums it is each
Item Index for examination mitigates compared with control group, and difference has conspicuousness.Illustrate to be made using the compound of lysozyme and plant extracts
Lotion, have a more apparent improvement to the oral health of people, especially in terms for the treatment of gingivitis and bleeding gums.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of shield range can also be made on the basis of above description and thinking for those of ordinary skill in the art
Other various forms of variations or variation, there is no necessity and possibility to exhaust all the enbodiments.It is all of the invention
Made any modifications, equivalent replacements, and improvements etc., should be included in the protection of the claims in the present invention within spirit and principle
Within the scope of.
Claims (10)
1. a kind of toothpaste containing lysozyme and plant extracts, which is characterized in that the toothpaste contain it is a kind of by lysozyme and
The compositions of additives of plant extracts composition；The plant extracts is Gotu Kola P.E, polygonum cuspidate root extract, scutellariae,radix
One of extract, tea extract, glycyrrhiza glabra root extract, german chamomile flower extract, rosemary leaf extract are a variety of.
2. toothpaste according to claim 1, which is characterized in that when plant extracts is a kind of, the lysozyme and plant
The mass ratio of extract is (0.01~10): (0.1~10)；
When plant extracts is two kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10): (0.1~
10): (0.1~10)；
When plant extracts is three kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10): (0.1~
10): (0.1~10): (0.1~10)；
When plant extracts is four kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10): (0.1~
10): (0.1~10): (0.1~10): (0.1~10)；
When plant extracts is five kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10): (0.1~
10): (0.1~10): (0.1~10): (0.1~10): (0.1~10)；
When plant extracts is six kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10): (0.1~
10): (0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10)；
When plant extracts is seven kinds, the mass ratio of the lysozyme and each plant extracts is (0.01~10): (0.1~
10): (0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10): (0.1~10).
3. toothpaste according to claim 2, which is characterized in that the toothpaste is grouped as by each group of following weight percent:
Moisturizer 10~50%, rubbing agent 10~40%, adhesive 0.1~3%, foaming agent 1~6%, essence 0.1~3%, sweetener
0.01~1%, lysozyme 0.01~10%, plant extracts 0.1~10%, excess water.
4. toothpaste according to claim 3, which is characterized in that the toothpaste is grouped as by each group of following weight percent:
Moisturizer 35~45%, rubbing agent 20~35%, adhesive 1~2%, foaming agent 2~4%, essence 0.1~3%, sweetener
0.1~0.5%, lysozyme 0.01~5%, plant extracts 0.1~10%, excess water.
5. toothpaste according to claim 3, which is characterized in that the moisturizer is sorbierite, polyethylene glycol, propylene glycol, sweet
One of oil is a variety of.
6. toothpaste according to claim 3, which is characterized in that the rubbing agent be silica, calcium carbonate, calcium monohydrogen phosphate,
One of aluminium hydroxide is a variety of.
7. toothpaste according to claim 3, which is characterized in that described adhesive is sodium carboxymethylcellulose, xanthan gum, OK a karaoke club
One of glue is a variety of.
8. toothpaste according to claim 3, which is characterized in that the foaming agent is lauryl sodium sulfate, lauroyl flesh ammonia
One of sour sodium, Cocoamidopropyl betaine, alkyl glycosides are a variety of.
9. toothpaste according to claim 3, which is characterized in that the toothpaste is grouped as by each group of following weight percent:
Sorbierite 42%, polyethylene glycol 2%, glycerol 1%, silica 20%, calcium carbonate 6%, calcium monohydrogen phosphate 4%, aluminium hydroxide
4%, sodium carboxymethylcellulose 0.5%, xanthan gum 0.4%, carragheen 0.2%, lauryl sodium sulfate 2%, lauroyl flesh ammonia
Sour sodium 1%, saccharin sodium 0.1%, Sucralose 0.1%, essence 1.2%, lysozyme 1%, Gotu Kola P.E 0.17%, polygonum cuspidate
Root extract 0.17%, radix scutellariae root extract 0.5%, tea extract 0.17%, glycyrrhiza glabra root extract 0.5%, german chamomile
Flower extract 0.17%, rosemary leaf extract 0.33%, excess water.
10. the preparation method of any one of claim 3 to 9 toothpaste, which comprises the steps of: in proportion plus
After entering moisturizer, rubbing agent, adhesive, water, foaming agent, sweetener, keeps vacuum degree in -0.090Mpa~-0.096Mpa, stir
Mix 20~50min；Then essence, lysozyme, plant extracts is added, keeps vacuum degree in -0.090Mpa~-0.096Mpa,
10~50min is stirred, lotion is made.
Priority Applications (1)
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Cited By (6)
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| CN111870687A (en) * | 2020-08-12 | 2020-11-03 | 好易康生物科技(广州)有限公司 | Oral bacteriostatic composition, oral care solution prepared from oral bacteriostatic composition and application of oral care solution |
| CN112336678A (en) * | 2020-12-03 | 2021-02-09 | 滁州向日葵药业有限公司 | Toothpaste capable of refreshing breath |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN112933217A (en) * | 2021-02-22 | 2021-06-11 | 西安佳立佳生物医药有限公司 | Oral care solution containing lysozyme and preparation method thereof |
| CN112972290A (en) * | 2021-03-16 | 2021-06-18 | 江苏雪豹日化有限公司 | Biological lysozyme composition for dental plaque |
| CN116898741A (en) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | Gum restoration toothpaste containing lysozyme and probiotics and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111870687A (en) * | 2020-08-12 | 2020-11-03 | 好易康生物科技(广州)有限公司 | Oral bacteriostatic composition, oral care solution prepared from oral bacteriostatic composition and application of oral care solution |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN112336678A (en) * | 2020-12-03 | 2021-02-09 | 滁州向日葵药业有限公司 | Toothpaste capable of refreshing breath |
| CN112336678B (en) * | 2020-12-03 | 2023-06-20 | 滁州向日葵药业有限公司 | Toothpaste capable of freshening breath |
| CN112933217A (en) * | 2021-02-22 | 2021-06-11 | 西安佳立佳生物医药有限公司 | Oral care solution containing lysozyme and preparation method thereof |
| CN112972290A (en) * | 2021-03-16 | 2021-06-18 | 江苏雪豹日化有限公司 | Biological lysozyme composition for dental plaque |
| CN116898741A (en) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | Gum restoration toothpaste containing lysozyme and probiotics and preparation method thereof |
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