CN101327266A - Oral cavity nursing agent for preventing and treating oral disease induced by Helicobacter pylori infection contamination - Google Patents
Oral cavity nursing agent for preventing and treating oral disease induced by Helicobacter pylori infection contamination Download PDFInfo
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- CN101327266A CN101327266A CNA2008100295464A CN200810029546A CN101327266A CN 101327266 A CN101327266 A CN 101327266A CN A2008100295464 A CNA2008100295464 A CN A2008100295464A CN 200810029546 A CN200810029546 A CN 200810029546A CN 101327266 A CN101327266 A CN 101327266A
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Abstract
The invention provides an oral cavity nursing agent for controlling the oral cavity diseases caused by the infection of helicobacter pylori. For every 100 weight proportions, the nursing agent comprises the effective constituents which are made from the supplementary materials accepted by pharmacy and the raw material medicines with the following weight proportions of 0.4-4 proportions of banlangen, 1.2-20 proportions of taraxacum and 1.3-20 proportions of cordate houttuynia herba. And at least one of the raw materials shall be the maximum proportion. The nursing agent of the invention has the function of inhibiting the helicobacter pylori in the mouth, and can effectively control a plurality of oral cavity diseases caused by the helicobacter pylori.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to medical configuration product, particularly a kind of pharmaceutical composition of making by Chinese medicine.
Background technology
(Helicobacterpylori, H.pylori HP) are a kind of Gram-negative spiral bacteria to helicobacter pylori, and nineteen eighty-three is separated from a chronic gastritis disease person with Marshall by Warren first and obtains.Many evidences show, have closely between harmonization of the stomach dudenal disease and the helicobacter pylori and get in touch.Though helicobacter pylori is external all responsive to a lot of materials, when clinical use real effectively medicine seldom, this may be because it easily produces due to drug resistance and the gastral special environment.If be used for the treatment of drug main antibiotic, antibacterial, proton pump inhibitor and secretion inhibitor class medicine that gastric HP infects.Because helicobacter pylori easily produces drug resistance, therefore use the treatment of antibiotic or antibacterial seldom separately, the most frequently used therapy is the triple therapy that proton pump inhibitor or bismuth level are mixed two kinds of compositions in clarithromycin, amoxicillin and three kinds of antibiotic of metronidazole at present.
Most for a long time scholars think that stomach is the main storage place of HP, but studies have shown that more and more the oral cavity also is the gathering ground of HP at human body, and think that oral cavity HP is one of key factor that causes oral diseases such as halitosis, oral ulcer, also be simultaneously one of reason of gastric HP infection and recurrence.Though existing data proof oral cavity HP and stomach HP homology, but be used for the treatment of the medicine of gastric HP infection and the little (Cheng Danying of effect that method infects oral cavity HP, the relation of oral helicobacter pylori and gastric helicobacter pylori infections, foreign medical science digestive disease fascicle, 2005,25 (1): 22-24).
Summary of the invention
The technical problem to be solved in the present invention provides the oral cavity nursing agent of the oral disease that a kind of control causes by helicobacter pylori infections.
The technical scheme that the present invention solves the problems of the technologies described above is:
A kind of oral cavity nursing agent of preventing and treating the oral disease that causes by helicobacter pylori infections, this nursing agent, per 100 weight portions are made up of the effective ingredient that acceptable accessories and following bulk drugs prepare: Radix Isatidis 0.4～4, Herba Taraxaci 1.2～20 and Herba Houttuyniae 1.3～20, and the consumption of at least a described crude drug is a upper limit amount.
Oral cavity nursing agent of the present invention, wherein the best proportioning of crude drug is: 13 parts of 4 parts of Radix Isatidis, 12 parts of Herba Taraxacis and Herba Houttuyniae.
Oral cavity nursing agent of the present invention can be dosage forms such as buccal tablet, collutory, gel, toothpaste, liniment or spray.
The preparation method of oral cavity nursing agent of the present invention is made up of following steps: take by weighing corresponding crude drug, after adding 10 times distilled water immersion 0.5h respectively by weight, decoct 30min, pour out decocting liquid with slow fire, medicinal residues add the equivalent distilled water again and decoct 30min, 2 times decocting liquid merges, and the centrifugal 15min of 3500rpm pours out supernatant, evaporation and concentration, behind the high pressure steam sterilization, the decocting liquid of each crude drug, get the required adjuvant of a certain amount of described decocting liquid and corresponding preparations at last and mix according to a conventional method and prepare.
In the oral cavity nursing agent of the present invention, Radix Isatidis is clinical antipyretic and antidotal type Chinese medicine commonly used, has pharmacological action widely, clinically is used for the treatment of multiple disease, especially based on antibiotic, antiviral therapy; Herba Taraxaci sweet in the mouth, hardship, cold in nature, have the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, its herb contains taraxasterol, choline, inulin, pectin etc., and water decoction has stronger inhibitory action to antibacterial; Herba Houttuyniae has the effect of heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, and existing clear and definite this grass contains multiple antimicrobial component such as houttuynine sodium bisulfite (being decanoylacetaldehyde), methylnonanone, myrcene, lauryl aldehyde, capric acid etc.These three kinds of Chinese herbal medicine have heat-clearing and toxic substances removing and antibacterial action according to the prescription of the different proportion that the in-vitro antibacterial experimental result is formed, particularly killing and suppress to have curative effect preferably gingival swelling and pain and oral helicobacter pylori.
In order to understand the present invention better, will prove technique effect of the present invention by experiment below.
One, extracorporeal bacteria inhibitor test:
Take by weighing Chinese medicine, after adding 10 times distilled water immersion 0.5h by weight, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges, the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid of crude drug amount 1g/ml concentration, and is standby behind the high pressure steam sterilization.Improvement Skirrow agar basal liquid reduces amount of water 20% when preparing by producer's regulation, to leave additional traditional Chinese medicine liquid for.Traditional Chinese medicine liquid is carried out doubling dilution with distilled water earlier, in vitro add the medicinal liquid and the culture medium of diluting toward sky afterwards in 1: 5 ratio, make that the Chinese medicine final concentration is respectively 200,100,50,25,12.5,6.25,3.13,1.57,0.79,0.39mg/ml in each test tube.High pressure steam sterilization is cooled to 50 ℃, adds defiber freeze thawing Sanguis Leporis seu oryctolagi and antibiotic mixed liquor, and making final concentration is freeze thawing Sanguis Leporis seu oryctolagi 5%, TMP 5mg/L, vancomycin 10mg/L, polymyxin B 2500IU/L.The above culture medium that contains different diluted concentration Chinese medicines is poured in the square ice cube mould of 3.4cm * 2.6cm, and each ice cube mould is adorned 5ml approximately, and 4 ice cube moulds can be placed in the same 9cm diameter culture dish simultaneously.Each each 2ul of ice cube mould inoculation NCTC11639 bacteria suspension is in 37 ℃ of little aerobic cultivation 72h.Observed result is contrast with the culture medium that does not contain medicinal liquid, and the minimum dilution factor of colony counts minimizing 90%, 75% and 50% is thought corresponding MIC value.Each dilution factor of every flavor Chinese medicine repeats 2 times.The display panel Cymbidium ensifolium (L.) Sw. root is to the MIC of helicobacter pylori as a result
50, MIC
75, MIC
90Value is respectively 0.39,1.57,6.25mg/ml.Herba Taraxaci is to the MIC of helicobacter pylori
50, MIC
75, MIC
90Value is respectively 12.5,100,200mg/ml.Herba Houttuyniae is to the MIC of helicobacter pylori
50, MIC
75, MIC
90Value is respectively 12.5,100,200mg/ml.
L9 (3 is pressed in the analysis of drug combination bacteriostatic experiment
4) orthogonal table design arrangement (as shown in table 1).Option board Cymbidium ensifolium (L.) Sw. root water decoction, Herba Houttuyniae water decoction, Herba Taraxaci water decoction be as 3 factors, according to preliminary experiment as a result each factor adopt 3 level (MIC
50, MIC
75, MIC
90), be divided into 9 groups and unite bacteriostatic experiment.
Factor-the water-glass of table 1 drug combination bacteriostatic experiment
| Factor | The A Radix Isatidis | The B Herba Houttuyniae | The C Herba Taraxaci |
| Level 1 | MIC 90 | MIC 50 | MIC 90 |
| Level 2 | MIC 50 | MIC 75 | MIC 50 |
| Level 3 | MIC 75 | MIC 90 | MIC 75 |
Annotate: A: Radix Isatidis, B: Herba Houttuyniae, C: Herba Taraxaci (down together).MIC
50, MIC
75And MIC
90After adopting the probit model analysis, draw.
The result shows in 9 kinds of combinations, needs only any single medicine MIC that contains
90The combination of concentration, its bacteriostasis rate all reaches more than 90%, as long as show that it is MIC that a kind of single medicine is arranged in the combination
90Concentration, and other two concentration is at MIC
50To MIC
90Combination preparation in the concentration range can effectively suppress the growth of helicobacter pylori.See Table two.
Table two, table 2 natural drug are united the inhibiting L9 (3 to Hp
4) Orthogonal experiment results
| The experiment number | A | B | C | Bacteriostasis rate |
| 1 | Level 1 | Level 1 | Level 1 | 95％ |
| 2 | Level 1 | Level 2 | Level 2 | 92％ |
| 3 | Level 1 | Level 3 | Level 3 | 96％ |
| 4 | Level 2 | Level 1 | Level 2 | 67％ |
| 5 | Level 2 | Level 2 | Level 3 | 81％ |
| 6 | Level 2 | Level 3 | Level 1 | 95％ |
| 7 | Level 3 | Level 1 | Level 3 | 82％ |
| 8 | Level 3 | Level 2 | Level 1 | 92％ |
| 9 | Level 3 | Level 3 | Level 2 | 91％ |
Two, clinical experiment:
1, experiment material:
Toothpaste of the present invention: press embodiment 6 described method preparations.
Ordinary toothpaste: ordinary toothpaste is not except that containing Radix Isatidis, Herba Taraxaci and Herba Houttuyniae, and all the other compositions are consistent with invention toothpaste.
2, experimental subject and grouping: select oral cavity Hp positive patient totally 100 examples, be divided into treatment group and matched group, each 50 example, matched group uses toothpaste of the present invention, matched group uses ordinary toothpaste, treatment group and matched group grouping are in strict conformity with the standard (p＞0.05) of harmony check, there was no significant difference aspect age and sex ratio and oral cavity prevalence.
3, experimental technique: used toothpaste continuously 3 months, and observed oral cavity Hp infection rate and oral disease incidence rate after half a year.For the guarantee test science objective, prevent the generation of bias, the definite International Classification or domestic common recognition suggestion standard of all adopting of the diagnostic criteria of all oral diseases and the order of severity in the process of test, the used toothpaste of the present invention of this experiment is consistent in outer package with ordinary toothpaste, and is consistent on the cream matter color and luster; The every required auxiliary examination of strict execution comprises that PCR detects oral cavity Hp.
4, experimental result: the treatment group after half a year oral cavity Hp infection rate reduce to 22% by 100%, the periodontitis incidence rate reduces to 20% by 60%, and matched group after half a year oral cavity Hp infection rate reduce to 95% by 100%, the periodontitis incidence rate reduces to 40% by 60%, and its difference has statistical significance (p＜0.05).
Conclusion: compare with ordinary toothpaste, toothpaste of the present invention can effectively be treated oral cavity Hp and be infected, and reduces the generation of oral disease.
The specific embodiment
Example 1
1, the preparation of each medical material water decoction:
Take by weighing Radix Isatidis 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Taraxaci 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Houttuyniae 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization.
2, be prepared into the oral care gels agent:
Get above-mentioned Radix Isatidis water decoction, Herba Taraxaci water decoction and each 2ml of Herba Houttuyniae water decoction, 12ml and the 13ml that contains crude drug amount 1g/ml concentration, sorbitol 12g, glycerol 1g, polyvidon 1g and hydroxy methocel 1g mix, to add to 100g canned after fully second homogenate is carried out with homogenizer in the dissolving back for water then, must oral care gels agent of the present invention.
Using method: used continuously 3 months, and observed oral cavity Hp infection conditions and oral disease improvement situation after half a year.
Example 2
1, the preparation of each medical material water decoction:
Take by weighing Radix Isatidis 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Taraxaci 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Houttuyniae 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization.
2, be prepared into the agent of mouth care matcha:
Get above-mentioned Radix Isatidis water decoction, Herba Taraxaci water decoction and each 0.4ml of Herba Houttuyniae water decoction, 12ml and the 20ml that contains crude drug amount 1g/ml concentration, glycerol 1g, polyvidon 3g and hydroxy methocel 1g mix, it is canned that water adds to 100g evacuation after fully stirring the back to carry out second homogenate with homogenizer then, must mouth care matcha of the present invention agent.
Using method: used continuously 3 months, and observed oral cavity Hp infection conditions and oral disease improvement situation after half a year.
Example 3
1, the preparation of each medical material water decoction:
Take by weighing Radix Isatidis 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Taraxaci 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Houttuyniae 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization.
2, be prepared into toothpaste:
Get the Radix Isatidis water decoction, Herba Taraxaci water decoction and each 0.4ml of Herba Houttuyniae water decoction, 20ml and the 13ml that contain crude drug amount 1g/ml concentration, glycerol 8g, sodium lauryl sulphate 3g, hydroxy methocel 2g, sorbitol 5g and dalcium biphosphate 5g, it is canned that water adds to 100g evacuation after fully stirring the back to carry out second homogenate with homogenizer then, must toothpaste of the present invention.
Using method: used continuously 3 months, and observed oral cavity Hp infection conditions and oral disease improvement situation after half a year.
Example 4
1, the preparation of each medical material water decoction:
Take by weighing Radix Isatidis 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Taraxaci 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Houttuyniae 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization.
2, be prepared into mouth care and smear spray:
Get the Radix Isatidis water decoction, Herba Taraxaci water decoction and each 1ml of Herba Houttuyniae water decoction, 6ml and the 6ml that contain crude drug amount 1g/ml concentration, glycerol 2g, sorbitol 5g and polyvidon 1g mix, to add to 100g canned after fully stirring the back to carry out second homogenate with homogenizer for water then, must mouth care spray of the present invention.
Using method: used continuously 3 months, and observed oral cavity Hp infection conditions and oral disease improvement situation after half a year.
Example 5
1, the preparation of each medical material water decoction:
Take by weighing Radix Isatidis 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Taraxaci 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Houttuyniae 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization.
2, be prepared into collutory:
Get above-mentioned Radix Isatidis water decoction, Herba Taraxaci water decoction and each 2ml of Herba Houttuyniae water decoction, 3ml and the 3ml that contains crude drug amount 1g/ml concentration, glycerol 3g and polyvidon 1g mix, to add to 100g canned after fully second homogenate is carried out with homogenizer in the dissolving back for water then, must collutory of the present invention.
Using method: used continuously 3 months, and observed oral cavity Hp infection conditions and oral disease improvement situation after half a year.
Example 6
1, the preparation of each medical material water decoction:
Take by weighing Radix Isatidis 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Taraxaci 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization;
Take by weighing Herba Houttuyniae 10g, press 100ml distilled water immersion 0.5h after, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, and 2 times decocting liquid merges the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration becomes to contain the medicinal liquid that the crude drug amount is 1gml, high pressure steam sterilization.
2, be prepared into toothpaste:
Get the Radix Isatidis water decoction, Herba Taraxaci water decoction and each 4ml of Herba Houttuyniae water decoction, 12ml and the 13ml that contain crude drug amount 1g/ml concentration, glycerol 8g, sodium lauryl sulphate 3g, hydroxy methocel 2g, sorbitol 5g and dalcium biphosphate 5g, it is canned that water adds to 100g evacuation after fully stirring the back to carry out second homogenate with homogenizer then, must toothpaste of the present invention.
Using method: used continuously 3 months, and observed oral cavity Hp infection conditions and oral disease improvement situation after half a year.
Example 7
1, the preparation of each medical material water decoction: identical with example 7, getting the crude drug amount is Radix Isatidis water decoction, Herba Taraxaci water decoction and the Herba Houttuyniae water decoction of equal 1g/ml.
2, make buccal tablet: get above-mentioned Radix Isatidis water decoction, Herba Taraxaci water decoction and each 2ml of Herba Houttuyniae water decoction, 12ml and the 13ml that contains crude drug amount 1g/ml concentration, be concentrated into extractum, it is standby that vacuum drying gets dry extract; Get white sugar, citric acid in 40 ℃～80 ℃ drying for standby; Dry extract, exsiccant white sugar and citric acid are mixed pulverizing, cross 60～80 mesh sieves, add stevioside two abundant mixings, granulate 40 ℃～80 ℃ oven dry; Granulate adds β one cyclodextrin and the magnesium stearate that comprises Oleum menthae during granulate; Tabletting.Using method: used continuously 3 months, and observed oral cavity Hp infection conditions and oral disease improvement situation after half a year.
Claims (4)
1, a kind of oral cavity nursing agent of preventing and treating the oral disease that causes by helicobacter pylori infections, this nursing agent, per 100 weight portions are made up of the effective ingredient that acceptable accessories and following bulk drugs prepare: Radix Isatidis 0.4～4, Herba Taraxaci 1.2～20 and Herba Houttuyniae 1.3～20, and the consumption of at least a described crude drug is a upper limit amount.
2, oral cavity nursing agent as claimed in claim 1 is characterized in that the proportioning of described crude drug is: Radix Isatidis 4, Herba Taraxaci 12 and Herba Houttuyniae 13.
3, oral cavity nursing agent as claimed in claim 1 is characterized in that described oral cavity nursing agent is buccal tablet, collutory, gel, toothpaste, liniment or spray.
4, the preparation method of claim 1,2 or 3 described oral cavity nursing agents, this method is made up of following steps: take by weighing corresponding crude drug, after adding 10 times distilled water immersion 0.5h respectively by weight, decoct 30min with slow fire, pour out decocting liquid, medicinal residues add the equivalent distilled water again and decoct 30min, merge decocting liquid twice, the centrifugal 15min of 3500rpm, pour out supernatant, evaporation and concentration is behind the high pressure steam sterilization, the decocting liquid of each crude drug, get the required adjuvant of a certain amount of described decocting liquid and corresponding preparations at last and mix according to a conventional method and prepare.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100295464A CN101327266B (en) | 2008-07-18 | 2008-07-18 | Oral cavity nursing agent for preventing and treating oral disease induced by Helicobacter pylori infection contamination |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100295464A CN101327266B (en) | 2008-07-18 | 2008-07-18 | Oral cavity nursing agent for preventing and treating oral disease induced by Helicobacter pylori infection contamination |
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| CN101327266B CN101327266B (en) | 2011-09-14 |
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|---|---|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861067A (en) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Application of Houttuynoid E in anti-helicobacter pylori (Hp) medicine |
| CN105362125A (en) * | 2015-11-10 | 2016-03-02 | 赤水市丹霞生产力促进中心有限公司 | Medicinal toothpaste with teeth-strengthening effect |
| CN106109365A (en) * | 2016-08-31 | 2016-11-16 | 武宝信 | A kind of for suppressing toothpaste and the compound method of helicobacter pylori |
| CN112545978A (en) * | 2020-12-15 | 2021-03-26 | 上海利康消毒高科技有限公司 | Oral care gel with effect of resisting helicobacter pylori in sustained manner and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1063641C (en) * | 1996-01-18 | 2001-03-28 | 邰全亮 | Chinese medicinal preparation for treatment of toothache |
-
2008
- 2008-07-18 CN CN2008100295464A patent/CN101327266B/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861067A (en) * | 2012-10-27 | 2013-01-09 | 吴俊华 | Application of Houttuynoid E in anti-helicobacter pylori (Hp) medicine |
| CN102861067B (en) * | 2012-10-27 | 2014-04-16 | 吴俊华 | Application of Houttuynoid E in preparing anti-helicobacter pylori (Hp) medicine |
| CN105362125A (en) * | 2015-11-10 | 2016-03-02 | 赤水市丹霞生产力促进中心有限公司 | Medicinal toothpaste with teeth-strengthening effect |
| CN106109365A (en) * | 2016-08-31 | 2016-11-16 | 武宝信 | A kind of for suppressing toothpaste and the compound method of helicobacter pylori |
| CN112545978A (en) * | 2020-12-15 | 2021-03-26 | 上海利康消毒高科技有限公司 | Oral care gel with effect of resisting helicobacter pylori in sustained manner and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101327266B (en) | 2011-09-14 |
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