CN103169891B - Novel vitamin C yinqiao tablet - Google Patents
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- CN103169891B CN103169891B CN201310134265.6A CN201310134265A CN103169891B CN 103169891 B CN103169891 B CN 103169891B CN 201310134265 A CN201310134265 A CN 201310134265A CN 103169891 B CN103169891 B CN 103169891B
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Abstract
The invention provides a novel vitamin C yinqiao tablet. The novel vitamin C yinqiao tablet is prepared from the following medicines in parts by weight: 60-360 parts of honeysuckle flowers, 60-360 parts of fructus forsythia, 24-144 parts of schizonepeta, 30-180 parts of fermented soybeans, 24-144 parts of lophatherum gracile, 36-216 parts of burdocks, 36-216 parts of reed rhizomes, 36-216 parts of platycodon grandiflorum, 30-180 parts of liquorices, 0.5-2 parts of chlorpheniramine maleate, 35-210 parts of paracetamol, 5-100 parts of vitamin C and 0.5-2 parts of peppermint oil. The novel vitamin C yinqiao tablet disclosed by the invention can be used for preventing pathogenic microorganisms including bacterial cold, viral cold as well as upper respiratory tract infection caused by mycoplasma and Chlamydia. Moreover, the novel vitamin C yinqiao tablet has a remarkable curative effect to the wind-cold type common cold and the wind-heat type common cold and is extensive in adaptation disease range.
Description
Technical field
The present invention relates to a kind of novel WEI C YINQIAO PIAN and preparation method thereof, belong to pharmaceutical field.
Background technology
The YINQIAO sheet is the Chinese patent medicine commonly used for the treatment of flu, by ingredients such as Flos Lonicerae, Fructus Forsythiae, Herba Menthae, Herba Schizonepetae, Semen Sojae Preparatum, Fructus Arctii, Radix Platycodonis, Herba Lophatheri, Radix Glycyrrhizaes.Its function suffering table that cools completely, heat-clearing and toxic substances removing, for anemopyretic cold, fever and headache, cough, xerostomia, the disease such as have sore throat.Summer and autumn, the anemopyretic cold person was more, and this product is particularly commonly used.
It is monarch drug that we be take Flos Lonicerae, Fructus Forsythiae, and heat-clearing and toxic substances removing, gently declare expelling pathogenic factors from the exterior.Herba Menthae, Herba Schizonepetae, Fructus Arctii etc. are ministerial drug, with the suffering table that cools completely, disperse the heresy of wind heat, and Fructus Arctii etc. are double can resolving toxin and disinhibiting the throat.The hot flat liter of compatibility Radix Platycodonis is floating, goes on and reaches table, draws floating a surname of all medicine liters and falls apart with the pathogenic factor in the exterior of dispelling, and lung qi dispersing eliminates the phlegm, the sore-throat relieving eliminating stagnation.Radix Glycyrrhizae is coordinating the actions of various ingredients in a prescription.In side, all medicines are worked in coordination, and play altogether suffering cool completely table and the merit of heat-clearing and toxic substances removing.
Vitamin C also can cure cold for anti-separately.When having some inkling of a cold, throat pain appears, during the symptoms such as rhinorrhea, can under physician guidance, take immediately 100 milligrams of vitamin Cs, can take again the vitamin C of same dosage after two hours, generally can make transference cure.If not yet take a turn for the better to the second day state of an illness, can increase ascorbic dose, can take 500 milligrams of left and right of vitamin C every day, continue to take till transference cure in view of this, people are when catching a cold, except the oral cold medicine, should take in right amount some vitamin Cs, in order to impel flu to fully recover early simultaneously.In addition due to human body when catching a cold, the resistance of each side all can decay, if can supplement in time some vitamin Cs, will receive better curative effect.
Can add vitamin C if take the YINQIAO sheet, promote each other, bring out the best in each other, make curative effect more remarkable simultaneously.Because cold virus, when invading human body, can cause interference to the NK immunocyte in body, and vitamin C can promote the growth of NK immunocyte, and produce interferon, so can prevent curing cold.The nonprescription drugs WEI C YINQIAO PIAN that pharmacy sells now, be exactly on the basis of YINQIAO sheet original prescription, adds the composition such as vitamin C made.
Owing to causing that now the flu pathogenic microorganism of curing the disease is varied, and the various variation patterns of the normal appearance of influenza virus, therefore, existing WEI C YINQIAO PIAN is when tackling pathogenic microorganism complicated and changeable, often unsatisfactory curative effect, therefore, need exploitation new, widely used anti-flu, antiviral Chinese medicine preparation.
Simultaneously, in the prescription of existing WEI C YINQIAO PIAN, chlorphenamine maleate, acetaminophen and vitamin C, it has mitigation very significantly to bringing down a fever with cold symptoms, still, mentioned component has very strong zest to stomach, the patient often causes gastric acid and other stomach discomfort, especially patients with gastric disease more to be difficult to apply this Drug therapy flu in the medication process, therefore, need to be improved current WEI C YINQIAO PIAN, to meet patient demand.
summary of the invention
The present invention seeks to, in order to overcome the deficiencies in the prior art, provides a kind of novel WEI C YINQIAO PIAN, by the medicine that comprises following weight proportion, is made:
Flos Lonicerae 60-360 part
Fructus Forsythiae 60-360 part
Herba Schizonepetae 24-144 part
Semen Sojae Preparatum 30-180 part
24-144 parts of Herba Lophatheris
36-216 parts of Fructus Arctiis
Rhizoma Phragmitis 36-216 part
Radix Platycodonis 36-216 part
Radix Glycyrrhizae 30-180 part
Chlorphenamine maleate 0.5-2 part
Acetaminophen 35-210 part
Vitamin C 15-100 part
Oleum menthae 0.5-2 part, wherein Oleum menthae mark meter by volume.
Further, by the medicine that comprises following weight proportion, made:
180 parts of Flos Lonicerae
180 parts of Fructus Forsythiaes
72 parts of Herba Schizonepetae
90 parts of Semen Sojae Preparatums
72 parts of Herba Lophatheris
108 parts of Fructus Arctiis
108 parts of Rhizoma Phragmitiss
90 parts, 108 portions of Radix Glycyrrhizaes of Radix Platycodonis
1.05 parts of chlorphenamine maleate
105 parts of acetaminophen
49.5 parts of vitamin Cs
1.08 parts of Oleum menthae.
Further, novel WEI C YINQIAO PIAN of the present invention also comprises the medicine of following weight proportion:
Radix Isatidis 30-180 part
Herba Taraxaci 30-180 part
Radix Puerariae 30-180 part
Radix Scutellariae 30-180 part
Fructus Trichosanthis 30-180 part.
Preferably, Radix Isatidis is 90 parts
90 parts of Herba Taraxacis
90 parts of Radix Puerariaes
90 parts of Radix Scutellariaes
90 parts of Fructus Trichosanthis.
Further, the novel WEI C YINQIAO PIAN of the present invention is double-layer tablet, multilayer tablet or sandwich, wherein comprises one deck slow release layer;
Described slow release layer comprises vitamin C, acetaminophen and chlorphenamine maleate;
Described slow release layer origin acid chlorphenamine 0.5-2 part, acetaminophen 35-210 part, vitamin C 15-100 part, hydroxypropyl cellulose 100-200 part and acrylic resin 100-200 part are made.
Preferably, described slow release layer is made by 160 parts of 1.05 parts of chlorphenamine maleate, 105 parts of acetaminophen, 49.5 parts of vitamin Cs, 160 parts of hydroxypropyl celluloses and acrylic resins.
The present invention also provides the preparation method of novel WEI C YINQIAO PIAN, and step of preparation process is as follows:
(1) Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae extract respectively volatile oil, and medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae, Radix Isatidis, Herba Taraxaci, Radix Puerariae, Radix Scutellariae, Fructus Trichosanthis decoct with water secondary, and each 0.5-4 hour, filter merging filtrate;
(2) Fructus Arctii extracts secondary with 60% alcohol heating reflux, and each 1-8 hour, filter, and merging filtrate reclaims ethanol, adds paraffin to make to dissolve, and is cooled to paraffin and floats on liquid level, removes paraffin layer;
(3) merge above-mentioned medicinal liquid, be concentrated into relative density 1.05-1.20, be dried to dried cream powder, add starch 500-2000 part, granulation, add above-mentioned volatile oil and Oleum menthae to mix;
(4) acetaminophen, chlorphenamine maleate, vitamin C, hydroxypropyl cellulose and acrylic resin, mix, granulation;
(5) use respectively the granule in step (3) and (4), be pressed into double-layer tablet, multilayer tablet or sandwich, film coating.
Compared with prior art, the present invention possesses following beneficial effect:
(1) can resist the centering pathogenic microorganism, the upper respiratory tract infection that for example bacillary, viral influenza, and mycoplasma, chlamydia cause.For anemofrigid cold and anemopyretic cold, significant curative effect is all arranged, indication is in extensive range.
(2) technology of having taked chlorphenamine maleate, acetaminophen and vitamin C are carried out slow release of the present invention, lowered the untoward reaction that the patient takes preparation of the present invention.Patients with gastric disease is not produced to side reaction, and due to ascorbic slow dispose procedure, the effect that the part gastritis sufferer is played to the protection gastric mucosa, can alleviate the gastritis symptom.Can alleviate gastritis in the time of preventing cold, through the inventor's research, the microbial gastritis of helicobacter pylorus be had to therapeutic effect.Widened the scope of application.
The specific embodiment
embodiment 1
one, prescription
Flos Lonicerae 60g
Fructus Forsythiae 60g
Herba Schizonepetae 24g
Semen Sojae Preparatum 30g
Herba Lophatheri 24g
Fructus Arctii 36g
Rhizoma Phragmitis 36g
Radix Platycodonis 36g
Radix Glycyrrhizae 30g
Chlorphenamine maleate 0.5g
Acetaminophen 35g
Vitamin C 15g
Oleum menthae 0.5ml
?
two, preparation method
(1) Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae extract respectively volatile oil, and medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae decoct with water secondary, and each 0.5-4 hour, filter merging filtrate;
(2) Fructus Arctii extracts secondary with 60% alcohol heating reflux, and each 1-8 hour, filter, and merging filtrate reclaims ethanol, adds paraffin to make to dissolve, and is cooled to paraffin and floats on liquid level, removes paraffin layer;
(3) merge above-mentioned medicinal liquid, be concentrated into relative density 1.05-1.20, be dried to dried cream powder, add starch 500g, granulation, add above-mentioned volatile oil and Oleum menthae to mix;
(4) acetaminophen, chlorphenamine maleate, vitamin C, hydroxypropyl cellulose 100g and acrylic resin 100g, mix granulation;
(5) use respectively the granule in step (3) and (4), be pressed into 2000 of multilayer tablets, film coating.
embodiment 2
one, prescription
Flos Lonicerae 360g
Fructus Forsythiae 360g
Herba Schizonepetae 144g
Semen Sojae Preparatum 180g
Herba Lophatheri 144g
Fructus Arctii 216g
Rhizoma Phragmitis 216g
Radix Platycodonis 216g
Radix Glycyrrhizae 180g
Chlorphenamine maleate 2g
Acetaminophen 210g
Vitamin C 100g
Oleum menthae 2ml
two, preparation method
(1) Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae extract respectively volatile oil, and medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae decoct with water secondary, and each 0.5-4 hour, filter merging filtrate;
(2) Fructus Arctii extracts secondary with 60% alcohol heating reflux, and each 1-8 hour, filter, and merging filtrate reclaims ethanol, adds paraffin to make to dissolve, and is cooled to paraffin and floats on liquid level, removes paraffin layer;
(3) merge above-mentioned medicinal liquid, be concentrated into relative density 1.05-1.20, be dried to dried cream powder, add starch 2000g, granulation, add above-mentioned volatile oil and Oleum menthae to mix;
(4) acetaminophen, chlorphenamine maleate, vitamin C, hydroxypropyl cellulose 200g and acrylic resin 200g, mix granulation;
(5) use respectively the granule in step (3) and (4), be pressed into 10000 of double-layer tablet, film coating.
embodiment 3
one, prescription
Flos Lonicerae 180g
Fructus Forsythiae 180 g
Herba Schizonepetae 72 g
Semen Sojae Preparatum 90 g
Herba Lophatheri 72 g
Fructus Arctii 108 g
Rhizoma Phragmitis 108 g
Radix Platycodonis 108 g Radix Glycyrrhizae 90 g
Chlorphenamine maleate 1.05 g
Acetaminophen 105 g
Vitamin C 49.5 g
Oleum menthae 1.08 ml
(1) Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae extract respectively volatile oil, medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae, decoct with water secondary, and each 0.5-4 hour, filter merging filtrate;
(2) Fructus Arctii extracts secondary with 60% alcohol heating reflux, and each 1-8 hour, filter, and merging filtrate reclaims ethanol, adds paraffin to make to dissolve, and is cooled to paraffin and floats on liquid level, removes paraffin layer;
(3) merge above-mentioned medicinal liquid, be concentrated into relative density 1.05-1.20, be dried to dried cream powder, add starch 1000g, granulation, add above-mentioned volatile oil and Oleum menthae to mix;
(4) acetaminophen, chlorphenamine maleate, vitamin C, hydroxypropyl cellulose 160g and acrylic resin 160g, mix granulation;
(5) use respectively the granule in step (3) and (4), be pressed into sandwich 5000, film coating.
embodiment 4
one, prescription
Flos Lonicerae 60g
Fructus Forsythiae 60g
Herba Schizonepetae 24g
Semen Sojae Preparatum 30g
Herba Lophatheri 24g
Fructus Arctii 36g
Rhizoma Phragmitis 36g
Radix Platycodonis 36g
Radix Glycyrrhizae 30g
Chlorphenamine maleate 0.5g
Acetaminophen 35g
Vitamin C 15g
Oleum menthae 0.5ml
Radix Isatidis 30g
Herba Taraxaci 30g
Radix Puerariae 30g
Radix Scutellariae 30g
Fructus Trichosanthis 30g
two, preparation method
(1) Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae extract respectively volatile oil, and medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae, Radix Isatidis, Herba Taraxaci, Radix Puerariae, Radix Scutellariae, Fructus Trichosanthis decoct with water secondary, and each 0.5-4 hour, filter merging filtrate;
(2) Fructus Arctii extracts secondary with 60% alcohol heating reflux, and each 1-8 hour, filter, and merging filtrate reclaims ethanol, adds paraffin to make to dissolve, and is cooled to paraffin and floats on liquid level, removes paraffin layer;
(3) merge above-mentioned medicinal liquid, be concentrated into relative density 1.05-1.20, be dried to dried cream powder, add starch 500g, granulation, add above-mentioned volatile oil and Oleum menthae to mix;
(4) acetaminophen, chlorphenamine maleate, vitamin C, hydroxypropyl cellulose 100g and acrylic resin 100g, mix granulation;
(5) use respectively the granule in step (3) and (4), be pressed into 2000 of double-layer tablet, film coating.
embodiment 5
one, prescription
Flos Lonicerae 360g
Fructus Forsythiae 360g
Herba Schizonepetae 144g
Semen Sojae Preparatum 180g
Herba Lophatheri 144g
Fructus Arctii 216g
Rhizoma Phragmitis 216g
Radix Platycodonis 216g
Radix Glycyrrhizae 180g
Chlorphenamine maleate 2g
Acetaminophen 210g
Vitamin C 100g
Oleum menthae 2ml
Radix Isatidis 180g
Herba Taraxaci 180g
Radix Puerariae 180g
Radix Scutellariae 180g
Fructus Trichosanthis 180g
(1) Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae extract respectively volatile oil, and medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae, Radix Isatidis, Herba Taraxaci, Radix Puerariae, Radix Scutellariae, Fructus Trichosanthis decoct with water secondary, and each 0.5-4 hour, filter merging filtrate;
(2) Fructus Arctii extracts secondary with 60% alcohol heating reflux, and each 1-8 hour, filter, and merging filtrate reclaims ethanol, adds paraffin to make to dissolve, and is cooled to paraffin and floats on liquid level, removes paraffin layer;
(3) merge above-mentioned medicinal liquid, be concentrated into relative density 1.05-1.20, be dried to dried cream powder, add starch 2000g, granulation, add above-mentioned volatile oil and Oleum menthae to mix;
(4) acetaminophen, chlorphenamine maleate, vitamin C, hydroxypropyl cellulose 200g and acrylic resin 200g, mix granulation;
(5) use respectively the granule in step (3) and (4), be pressed into 10000 of double-layer tablet, film coating.
embodiment6
One, prescription
Flos Lonicerae 180g
Fructus Forsythiae 180 g
Herba Schizonepetae 72 g
Semen Sojae Preparatum 90 g
Herba Lophatheri 72 g
Fructus Arctii 108 g
Rhizoma Phragmitis 108 g
Radix Platycodonis 108 g Radix Glycyrrhizae 90 g
Chlorphenamine maleate 1.05 g
Acetaminophen 105 g
Vitamin C 49.5 g
Oleum menthae 1.08 ml
90 parts of Radix Isatidis
Herba Taraxaci 90g
Radix Puerariae 90g
Radix Scutellariae 90g
Fructus Trichosanthis 90g
Two, preparation method
(1) Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae extract respectively volatile oil, and medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae, Radix Isatidis, Herba Taraxaci, Radix Puerariae, Radix Scutellariae, Fructus Trichosanthis decoct with water secondary, and each 0.5-4 hour, filter merging filtrate;
(2) Fructus Arctii extracts secondary with 60% alcohol heating reflux, and each 1-8 hour, filter, and merging filtrate reclaims ethanol, adds paraffin to make to dissolve, and is cooled to paraffin and floats on liquid level, removes paraffin layer;
(3) merge above-mentioned medicinal liquid, be concentrated into relative density 1.05-1.20, be dried to dried cream powder, add starch 1000g, granulation, add above-mentioned volatile oil and Oleum menthae to mix;
(4) acetaminophen, chlorphenamine maleate, vitamin C, hydroxypropyl cellulose 160g and acrylic resin 160g, mix granulation;
(5) use respectively the granule in step (3) and (4), be pressed into 5000 of multilayer tablets, film coating.
the therapeutic effect of the novel WEI C YINQIAO PIAN of effect test example 1 the present invention to viral influenza
140 routine viral influenza cases are divided into to 7 groups, and the WEI C YINQIAO PIAN and the existing WEI C YINQIAO PIAN that impose respectively embodiment of the present invention 1-6 formula preparation are treated.How anxious symptom just onset is, with nose mucositis symptom and sneeze, watery nasal discharge, nasal obstruction; Very the person has: aversion to wind and cold, heating, headache, giddy, cough etc.The acute viral pharyngitis with pharyngeal itch and and pharyngeal burning sensation, pharyngalgia can be with fever and headache, to cough weak etc. be cardinal symptom.The viral laryngitis of main acute pain during with hoarseness, difficulty speaking, cough is often cardinal symptom with heating, cough etc.Visible nasal membrane congestion and edema, have secretions.Pharyngeal mild hyperaemia.The visible pharyngeal obvious hyperemia of viral pharyngitis and edema, the enlargement of neck submental lymph nodes, and tenderness is arranged.But and viral laryngitis congested, edema of throat while checking, regional nodes's silght enlargement and tenderness, also can hear whoop.
With the tablet made in embodiment 1-6, treated, wherein one day 3 times, each 3, treating 7 days is one
The individual course for the treatment of.
Curative effect determinate standard: take interior clinical symptom disappearance person in 7 days as effective, otherwise be invalid.
therapeutic effect and the untoward reaction of the novel WEI C YINQIAO PIAN of effect test example 2 the present invention to all types of flu
Viral influenza is the common respiratory infectious disease caused by multiple virus.Main manifestations is the symptoms such as sneeze, nasal obstruction, rhinorrhea, dry pharynx, pharyngalgia, cough, hoarseness.Whole body shows as headache, aches all over, fatigue and weak, inappetence, or does not generate heat, or low grade fever, or the symptoms such as high heat, fear of cold.
The bacillary clinical symptoms to viral respiratory tract infection is more similar, and bacillary flu is due to due to antibacterial, and when antibacterial infects, total white blood cells and neutrophilic granulocyte percent all are shown in height.
Anemopyretic cold, cardinal symptom: aversion to wind, antiperspirant or lossless, headache, conjunctival congestion, nasal obstruction rhinorrhea, sneeze cough are arranged, the thick color of expectorant is white or Huang, thirsty pharyngalgia, swallows red or swollen, red tongue, thin white fur of tongue or BOHUANG.
Treatment policy: need wind and heat dispersing, diffusing lung, relieving exterior syndrome.
Anemofrigid cold, cardinal symptom: be more common in and have some inkling of a cold, heating be afraid of cold (take and be afraid of cold as main even shiver with cold), tired mind, heating is lighter, lossless or slight perspiration, stuffy nose with watery discharge, sneeze, bring up phlegm when one coughs, sputum green grass or young crops is rare, throat is itched not the wish drink, swallow red not significantly, thin white fur of tongue.
For 200 example flu patients, the WEI C YINQIAO PIAN and the existing WEI C YINQIAO PIAN that impose respectively the embodiment of the present invention 6 formula preparations are treated, and wherein one day 3 times, each 3, treating 7 days is a course for the treatment of.Record therapeutic effect and untoward reaction.Curative effect determinate standard: take interior clinical symptom disappearance person in 7 days as effective, otherwise be invalid.
The present invention is not limited to above-mentioned embodiment, if various changes of the present invention or modification are not broken away to the spirit and scope of the present invention, if, within these changes and modification belong to claim of the present invention and equivalent technologies scope, the present invention also is intended to comprise these changes and change.
Claims (7)
1. a novel WEI C YINQIAO PIAN, by the medicine of following weight proportion, made:
Flos Lonicerae 60-360 part
Fructus Forsythiae 60-360 part
Herba Schizonepetae 24-144 part
Semen Sojae Preparatum 30-180 part
24-144 parts of Herba Lophatheris
36-216 parts of Fructus Arctiis
Rhizoma Phragmitis 36-216 part
Radix Platycodonis 36-216 part
Radix Glycyrrhizae 30-180 part
Chlorphenamine maleate 0.5-2 part
Acetaminophen 35-210 part
Vitamin C 15-100 part
Oleum menthae 0.5-2 part, wherein Oleum menthae mark meter by volume
Radix Isatidis 30-180 part
Herba Taraxaci 30-180 part
Radix Puerariae 30-180 part
Radix Scutellariae 30-180 part
Fructus Trichosanthis 30-180 part.
2. WEI C YINQIAO PIAN according to claim 1, is characterized in that, by the medicine of following weight proportion, made:
180 parts of Flos Lonicerae
180 parts of Fructus Forsythiaes
72 parts of Herba Schizonepetae
90 parts of Semen Sojae Preparatums
72 parts of Herba Lophatheris
108 parts of Fructus Arctiis
108 parts of Rhizoma Phragmitiss
90 parts, 108 portions of Radix Glycyrrhizaes of Radix Platycodonis
1.05 parts of chlorphenamine maleate
105 parts of acetaminophen
49.5 parts of vitamin Cs
1.08 parts of Oleum menthae
90 parts of Radix Isatidis
90 parts of Herba Taraxacis
90 parts of Radix Puerariaes
90 parts of Radix Scutellariaes
90 parts of Fructus Trichosanthis.
3. according to the described WEI C YINQIAO PIAN of claim 1-2 any one, it is characterized in that, described WEI C YINQIAO PIAN is double-layer tablet, multilayer tablet or sandwich, wherein comprises one deck slow release layer.
4. WEI C YINQIAO PIAN according to claim 3, is characterized in that, described slow release layer comprises vitamin C, acetaminophen and chlorphenamine maleate.
5. WEI C YINQIAO PIAN according to claim 4, is characterized in that, described slow release layer is made by chlorphenamine maleate, acetaminophen, vitamin C, hydroxypropyl cellulose 100-200 part and acrylic resin 100-200 part.
6. WEI C YINQIAO PIAN according to claim 4, is characterized in that, described slow release layer is made by 160 parts of 1.05 parts of chlorphenamine maleate, 105 parts of acetaminophen, 49.5 parts of vitamin Cs, 160 parts of hydroxypropyl celluloses and acrylic resins.
7. as the preparation method of the described WEI C YINQIAO PIAN of claim 4-6 any one, it is characterized in that, step of preparation process is as follows:
(1) Fructus Forsythiae, Herba Schizonepetae, Flos Lonicerae extract respectively volatile oil, and medicinal residues and Herba Lophatheri, Semen Sojae Preparatum, Rhizoma Phragmitis, Radix Platycodonis, Radix Glycyrrhizae, Radix Isatidis, Herba Taraxaci, Radix Puerariae, Radix Scutellariae, Fructus Trichosanthis decoct with water secondary, and each 0.5-4 hour, filter merging filtrate;
(2) Fructus Arctii extracts secondary with 60% alcohol heating reflux, and each 1-8 hour, filter, and merging filtrate reclaims ethanol, adds paraffin to make to dissolve, and is cooled to paraffin and floats on liquid level, removes paraffin layer;
(3) merge above-mentioned medicinal liquid, be concentrated into relative density 1.05-1.20, be dried to dried cream powder, add starch 500-2000 part, granulation, add above-mentioned volatile oil and Oleum menthae to mix;
(4) acetaminophen, chlorphenamine maleate, vitamin C, hydroxypropyl cellulose and acrylic resin, mix, granulation;
(5) use respectively the granule in step (3) and (4), be pressed into double-layer tablet, multilayer tablet or sandwich, film coating.
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| CN104189588A (en) * | 2014-09-11 | 2014-12-10 | 江西九华药业有限公司 | Vitamin C Yinqiao tablets and preparation method thereof |
| CN104474314A (en) * | 2014-11-20 | 2015-04-01 | 西安阿房宫药业股份有限公司 | Composition for treating colds and preparation method of composition |
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| CN113350299B (en) * | 2021-06-28 | 2022-09-06 | 陕西映诺嘉生物科技有限公司 | Slow-release medicine suitable for pets and preparation method thereof |
| CN114832086A (en) * | 2022-05-26 | 2022-08-02 | 李彩勤 | A Chinese medicinal tablet for treating vitiligo, and its preparation method |
| CN115531493B (en) * | 2022-09-30 | 2024-03-29 | 九华华源药业(桂林)有限公司 | Compound preparation and preparation method thereof |
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
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| CN1380098A (en) * | 2002-05-20 | 2002-11-20 | 张勇飞 | Anti-infection compound preparation and its preparation method |
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| 维C银翘片;药典委员会;《中华人民共和国药典2010版第一部》;20101231;1139 * |
| 药典委员会.维C银翘片.《中华人民共和国药典2010版第一部》.2010, |
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