CN103784336A - Toothpaste containing bovine lactoferrin - Google Patents
Toothpaste containing bovine lactoferrin Download PDFInfo
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- CN103784336A CN103784336A CN201410036847.5A CN201410036847A CN103784336A CN 103784336 A CN103784336 A CN 103784336A CN 201410036847 A CN201410036847 A CN 201410036847A CN 103784336 A CN103784336 A CN 103784336A
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Abstract
The invention discloses toothpaste containing bovine lactoferrin, belonging to the technical field of toothpaste. The toothpaste consists of the following components in parts by weight: 38-50 parts of calcium hydrogen phosphate dihydrate, 8-12 parts of sorbitol, 2-4 parts of sodium lauryl sulfate, 0.5-1.5 parts of peppermint oil, 6-14 parts of glycerin, 1-2 parts of sodium carboxymethylcellulose, 1-1.5 parts of sodium benzoate, 20-35 parts of water and 0.2-2 parts of bovine lactoferrin. The toothpaste can be used for effectively preventing infection of oral helicobacter pylori, and has a certain treatment effect on people infected with helicobacter pylori. The bovine lactoferrin serving as an effective component of the composition is a nutritional factor beneficial to human bodies and does not cause any side effect after long-term use, and is a safe additive.
Description
Technical field
The invention belongs to toothpaste technical field, be specifically related to a kind of toothpaste containing Bovine Lactoferrin that prevents Helicobacter pylori infection.
Background technology
Gastric ulcer, gastritis, the diseases such as duodenal ulcer are all because infecting due to helicobacter pylori.Main pathogenesis is: make helicobacter pylori penetrate the factor that rete malpighii is settled down on gastric epithelial cell surface; Gastric epithelial cell etc. is played to the toxin factor of destruction; Various inflammatory cells and inflammatory mediator; Immune-reactive substance etc.The microbial gastrointestinal disease of helicobacter pylorus is that a kind of refractory is healed, infectious disease, and along with the crowd who infects helicobacter pylori constantly increases, the infection of prevention helicobacter pylori becomes a urgent task
As the saying goes, illness finds its way in by the mouth, and the patient of many infection helicobacter pyloris is due to improper diet, infected the helicobacter pylori in food, helicobacter pylori is bred in oral cavity, due to being swallowed when having a meal or drinking water, can remove a part of antibacterial although brush teeth, allow and be so difficult to eradicate.
At present, on market, be badly in need of a kind of articles for daily use of prevention infection helicobacter pylori in time, toothpaste is the articles for daily use that a kind of people can use every day, therefore, in toothpaste, adding the material of prevention infection helicobacter pylori, is a kind of way of well dealing with problems.
Bovine Lactoferrin is a kind of basic protein extracting from Lac Bovis seu Bubali, has multiple biological activity, develops the using value of this albumen, is a focus of studying at present.
Summary of the invention
The gastrointestinal disease that the present invention is directed to current infection helicobacter pylori is difficult to radical cure, and liable to infection problem proposes a kind of toothpaste containing Bovine Lactoferrin.
A kind of toothpaste containing Bovine Lactoferrin, material by following parts by weight forms: dicalcium phosphate dihydrate 38-50 part, sorbitol 8-12 part, sodium laurylsulfate 2-4 part, Oleum menthae 0.5-1.5 part, glycerol 6-14 part, sodium carboxymethyl cellulose 1-2 part, sodium benzoate 1-1.5 part, water 20-35 part, Bovine Lactoferrin 0.2-2 part.
Preferably, the described toothpaste containing Bovine Lactoferrin is made up of the material of following parts by weight: 44 parts of dicalcium phosphate dihydrates, 10 parts of sorbitol, 3 parts of sodium laurylsulfates, 1 part of Oleum menthae, 10 parts of glycerol, 1.5 parts of sodium carboxymethyl cellulose, 0.5 part of sodium benzoate, 28 parts, water, 1 part of Bovine Lactoferrin.
Preferably, the described toothpaste containing Bovine Lactoferrin is made up of the material of following parts by weight: 40 parts of dicalcium phosphate dihydrates, 10 parts of sorbitol, 3 parts of sodium laurylsulfates, 1 part of Oleum menthae, 10 parts of glycerol, 1.5 parts of sodium carboxymethyl cellulose, 0.5 part of sodium benzoate, 28 parts, water, 6 parts of Bovine Lactoferrin.
The application of the above-mentioned toothpaste containing Bovine Lactoferrin aspect prevention Helicobacter pylori infection.
Beneficial effect of the present invention: toothpaste of the present invention can effectively prevent Helicobacter pylori infection, and the gastroenteropathy of the Helicobacter pylori infection having occurred is had to certain therapeutic efficiency, compositions active component lactoferrin of the present invention is the trophic factors useful to human body, with not having side effects, be a kind of safe substance for a long time.
The specific embodiment
Below in conjunction with specific embodiment, the present invention will be further described.
Embodiment 1
Containing a toothpaste for Bovine Lactoferrin, formed by following material: dicalcium phosphate dihydrate 44g, sorbitol 10g, sodium laurylsulfate 3g, Oleum menthae 1g, glycerol 10g, sodium carboxymethyl cellulose 1.5g, sodium benzoate 0.5g, water 28g, Bovine Lactoferrin 1g.
Embodiment 2
Containing a toothpaste for Bovine Lactoferrin, formed by following material: dicalcium phosphate dihydrate 40g, sorbitol 10g, sodium laurylsulfate 3g, Oleum menthae 1g, glycerol 10g, sodium carboxymethyl cellulose 1.5g, sodium benzoate 0.5g, water 28g, Bovine Lactoferrin 6g.
Embodiment 3
Containing a toothpaste for Bovine Lactoferrin, formed by following material: dicalcium phosphate dihydrate 38g, sorbitol 8g, sodium laurylsulfate 2g, Oleum menthae 0.5g, glycerol 6g, sodium carboxymethyl cellulose 1g, sodium benzoate 1g, water 20g, Bovine Lactoferrin 0.2g.
Embodiment 4
Containing a toothpaste for Bovine Lactoferrin, formed by following material: dicalcium phosphate dihydrate 50g, sorbitol 12g, sodium laurylsulfate 4g, Oleum menthae 1.5g, glycerol 14g, sodium carboxymethyl cellulose 2g, sodium benzoate 1.5g, water 35g, Bovine Lactoferrin 2g.
Embodiment 5
Gastric ulcer treatment experimental technique: the patients w ith peptic ulcer disease of selecting 80 routine helicobacter pylori infections, be divided into treatment group (40 example) and matched group (40 example), treatment group adopts the toothpaste of embodiment 1 to brush teeth, every day 2 times, each consumption 2g, matched group adopts omeprazole, take every day 2 times, each serving using 20mg, treatment cycle is 6 months, after 6 months, relatively therapeutic effect.
Gastric ulcer treatment experimental result: treatment group and matched group gastric ulcer treatment clearance are respectively 70.1% and 69.9%, and matched group and treatment group do not have obvious difference, proves that these cosmetics can reach effective prevention and suppress helicobacter pylori infection effect.
Embodiment 6
Containing a toothpaste for Bovine Lactoferrin, formed by following material: dicalcium phosphate dihydrate 44g, sorbitol 10g, sodium laurylsulfate 3g, 3 parts of little Herba chenopodii extracts, Oleum menthae 1g, glycerol 10g, sodium carboxymethyl cellulose 1.5g, sodium benzoate 0.5g, water 28g, Bovine Lactoferrin 1g.
The preparation method of described little Herba chenopodii extract: little Herba chenopodii is dried, pulverize, pack into decoct in bag and soak 4-10h, move in Decocting pot, decoct 4-9h under temperature 80-110 degree condition, finally by decoction liquor powder by spraying, obtain little Herba chenopodii extract.
Above-mentioned composition, except suppressing helicobacter pylori infections, can also prevent and treat dental caries tooth disease, periodontitis, and experimental verification is as follows:
Gastric ulcer treatment experimental technique: the patients w ith peptic ulcer disease of selecting 80 routine helicobacter pylori infections, be divided into treatment group (40 example) and matched group (40 example), treatment group adopts the toothpaste of the present embodiment to brush teeth, every day 2 times, each consumption 2g, matched group adopts omeprazole, take every day 2 times, each serving using 20mg, treatment cycle is 6 months, after 6 months, relatively therapeutic effect.
Gastric ulcer treatment experimental result: treatment group and matched group gastric ulcer treatment clearance are respectively 72.1% and 71.7%, and matched group and treatment group do not have obvious difference, proves that these cosmetics can reach effective prevention and suppress helicobacter pylori infection effect.
The toothpaste of making is divided into two groups, and one group is carried out dental caries tooth disease treatment experiment, and one group is carried out periodontitis and improves experiment.
Dental caries tooth disease treatment experimental technique: select 80 routine dental caries tooth disease patients, be divided into treatment group (40 example) and matched group (40 example), treatment group adopts the toothpaste of embodiment 1 to brush teeth, every day 2 times (sooner or later respectively once), matched group adopts tetracycline antibiotic conventional therapy, medication every day 2 times, treatment cycle is 3 months, relapse rate is added up in drug withdrawal after 1 month.
Dental caries tooth disease treatment experimental result: the relapse rate for the treatment of group and matched group dental caries tooth disease is respectively 11.3% and 11.6%, treatment group and matched group no significant difference, prove that this dentifrice composition has good effect to prevention and treatment dental caries tooth disease, proves that little Herba chenopodii extract has played effective effect therein.
Periodontitis improves experimental technique: the 80 cases of selecting to suffer from periodontitis, age is between 45-55 year, adopt the toothpaste of embodiment 1 to brush teeth, every day 2 times (sooner or later respectively once), after brushing teeth 3 months, periodontitis elimination factor is 10%, the periodontitis elimination factor after half a year of brushing teeth is 40%, and after brushing teeth 1 year, periodontitis elimination factor is 90%, and after a year and a half of brushing teeth, periodontitis elimination factor is 90%.Above-mentionedly experimental results show that said composition has certain preventive and therapeutic action to periodontitis, prove that little Herba chenopodii extract has played effective effect therein.
Claims (4)
1. the toothpaste containing Bovine Lactoferrin, it is characterized in that, material by following parts by weight forms: dicalcium phosphate dihydrate 38-50 part, sorbitol 8-12 part, sodium laurylsulfate 2-4 part, Oleum menthae 0.5-1.5 part, glycerol 6-14 part, sodium carboxymethyl cellulose 1-2 part, sodium benzoate 1-1.5 part, water 20-35 part, Bovine Lactoferrin 0.2-2 part.
2. a kind of toothpaste containing Bovine Lactoferrin according to claim 1, it is characterized in that, the described toothpaste containing Bovine Lactoferrin is made up of the material of following parts by weight: 44 parts of dicalcium phosphate dihydrates, 10 parts of sorbitol, 3 parts of sodium laurylsulfates, 1 part of Oleum menthae, 10 parts of glycerol, 1.5 parts of sodium carboxymethyl cellulose, 0.5 part of sodium benzoate, 28 parts, water, 1 part of Bovine Lactoferrin.
3. a kind of toothpaste containing Bovine Lactoferrin according to claim 1, it is characterized in that, the described toothpaste containing Bovine Lactoferrin is made up of the material of following parts by weight: 40 parts of dicalcium phosphate dihydrates, 10 parts of sorbitol, 3 parts of sodium laurylsulfates, 1 part of Oleum menthae, 10 parts of glycerol, 1.5 parts of sodium carboxymethyl cellulose, 0.5 part of sodium benzoate, 28 parts, water, 6 parts of Bovine Lactoferrin.
Described in claim 1 containing the toothpaste of Bovine Lactoferrin in the application aspect prevention Helicobacter pylori infection.
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| CN201410036847.5A CN103784336B (en) | 2014-01-26 | 2014-01-26 | A kind of toothpaste containing Bovine Lactoferrin |
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| CN201410036847.5A CN103784336B (en) | 2014-01-26 | 2014-01-26 | A kind of toothpaste containing Bovine Lactoferrin |
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| CN103784336B CN103784336B (en) | 2016-06-29 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105434264A (en) * | 2015-12-22 | 2016-03-30 | 南昌理工学院 | Motherwort-herb toothpaste |
| WO2016100516A1 (en) * | 2014-12-16 | 2016-06-23 | Axim Biotechnologies, Inc. | Oral care composition comprising cannabinoids |
| CN107753317A (en) * | 2016-08-22 | 2018-03-06 | 上海利康消毒高科技有限公司 | A kind of Chinese herbaceous peony and chamomile mixed essential oil dentistry postoperative care toothpaste |
| CN109498542A (en) * | 2018-12-29 | 2019-03-22 | 泰州优克生物科技有限公司 | A kind of biological toothpaste for anti-helicobacter pylori |
| CN110075036A (en) * | 2019-06-17 | 2019-08-02 | 广东天丝饮料有限公司 | Anti- oral helicobacter pylori medicated toothpaste |
Citations (1)
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| CN1244386A (en) * | 1998-08-07 | 2000-02-16 | 青木秀希 | Oral cleaning detergent component and tooth-paste, tooth powder component |
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2014
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1244386A (en) * | 1998-08-07 | 2000-02-16 | 青木秀希 | Oral cleaning detergent component and tooth-paste, tooth powder component |
Non-Patent Citations (1)
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| 骆希明: "专利文摘", 《牙膏工业》 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016100516A1 (en) * | 2014-12-16 | 2016-06-23 | Axim Biotechnologies, Inc. | Oral care composition comprising cannabinoids |
| US10172786B2 (en) | 2014-12-16 | 2019-01-08 | Axim Biotechnologies, Inc. | Oral care composition comprising cannabinoids |
| EP3865113A1 (en) * | 2014-12-16 | 2021-08-18 | APIRX Pharmaceutical USA, LLC | Oral care composition comprising cannabinoids |
| US11890361B2 (en) | 2014-12-16 | 2024-02-06 | Apirx Pharmaceutical Usa, Llc | Oral care composition comprising cannabinoids |
| CN105434264A (en) * | 2015-12-22 | 2016-03-30 | 南昌理工学院 | Motherwort-herb toothpaste |
| CN105434264B (en) * | 2015-12-22 | 2018-06-29 | 南昌理工学院 | A kind of motherwort toothpaste |
| CN107753317A (en) * | 2016-08-22 | 2018-03-06 | 上海利康消毒高科技有限公司 | A kind of Chinese herbaceous peony and chamomile mixed essential oil dentistry postoperative care toothpaste |
| CN109498542A (en) * | 2018-12-29 | 2019-03-22 | 泰州优克生物科技有限公司 | A kind of biological toothpaste for anti-helicobacter pylori |
| CN110075036A (en) * | 2019-06-17 | 2019-08-02 | 广东天丝饮料有限公司 | Anti- oral helicobacter pylori medicated toothpaste |
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| CN103784336B (en) | 2016-06-29 |
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Effective date of registration: 20170427 Address after: 230000 Anhui, Hefei innovation Avenue, race for the building 666 Patentee after: HEFEI SUNWIN SMART HEALTHCARE CO., LTD. Address before: Room 1, building 168, Fenghuang West Road, Jiangsu, Taizhou, 225300, China Patentee before: TAIZHOU BIERFU BIOLOGICAL SCIENCE & TECHNOLOGY CO., LTD. |
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Effective date of registration: 20200713 Address after: 230000 south, 4th floor, Saiwei building, NO.666, innovation Avenue, hi tech Zone, Hefei City, Anhui Province Patentee after: Hefei bilf Biotechnology Co., Ltd Address before: 230000 Anhui, Hefei innovation Avenue, race for the building 666 Patentee before: HEFEI SUNWIN SMART HEALTHCARE Co.,Ltd. |