CN102512337B - Night toothpaste and morning and night combination toothpaste - Google Patents
Night toothpaste and morning and night combination toothpaste Download PDFInfo
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- CN102512337B CN102512337B CN 201210005858 CN201210005858A CN102512337B CN 102512337 B CN102512337 B CN 102512337B CN 201210005858 CN201210005858 CN 201210005858 CN 201210005858 A CN201210005858 A CN 201210005858A CN 102512337 B CN102512337 B CN 102512337B
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- 229940034610 toothpaste Drugs 0.000 title claims abstract description 67
- 239000000606 toothpaste Substances 0.000 title claims abstract description 67
- 229920000642 polymer Polymers 0.000 claims abstract description 19
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- 230000008901 benefit Effects 0.000 claims description 36
- 230000004048 modification Effects 0.000 claims description 31
- 238000012986 modification Methods 0.000 claims description 31
- 230000009286 beneficial effect Effects 0.000 claims description 21
- 230000000844 anti-bacterial effect Effects 0.000 claims description 18
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 239000003463 adsorbent Substances 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000003082 abrasive agent Substances 0.000 claims description 11
- 239000008367 deionised water Substances 0.000 claims description 11
- 229910021641 deionized water Inorganic materials 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- 239000000080 wetting agent Substances 0.000 claims description 10
- 239000002131 composite material Substances 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 230000032683 aging Effects 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 7
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 7
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 7
- 239000000017 hydrogel Substances 0.000 claims description 7
- 230000007062 hydrolysis Effects 0.000 claims description 7
- 238000006460 hydrolysis reaction Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000003825 pressing Methods 0.000 claims description 7
- 239000007787 solid Substances 0.000 claims description 7
- 238000001291 vacuum drying Methods 0.000 claims description 7
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical group [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 6
- 229920006243 acrylic copolymer Polymers 0.000 claims description 4
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 4
- 235000011180 diphosphates Nutrition 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 3
- JBIROUFYLSSYDX-UHFFFAOYSA-M benzododecinium chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 JBIROUFYLSSYDX-UHFFFAOYSA-M 0.000 claims description 3
- 229960003260 chlorhexidine Drugs 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 2
- 238000001354 calcination Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 239000002808 molecular sieve Substances 0.000 claims description 2
- 239000000741 silica gel Substances 0.000 claims description 2
- 229910002027 silica gel Inorganic materials 0.000 claims description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 claims description 2
- 206010006326 Breath odour Diseases 0.000 abstract description 19
- 208000032139 Halitosis Diseases 0.000 abstract description 18
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 abstract description 10
- 239000011746 zinc citrate Substances 0.000 abstract description 10
- 229940068475 zinc citrate Drugs 0.000 abstract description 10
- 235000006076 zinc citrate Nutrition 0.000 abstract description 10
- 239000003205 fragrance Substances 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 5
- 230000008859 change Effects 0.000 abstract description 4
- 239000003906 humectant Substances 0.000 abstract 2
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 239000000022 bacteriostatic agent Substances 0.000 abstract 1
- 210000000214 mouth Anatomy 0.000 description 24
- 239000000203 mixture Substances 0.000 description 23
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
- 239000000049 pigment Substances 0.000 description 8
- 229940085605 saccharin sodium Drugs 0.000 description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 8
- 235000010234 sodium benzoate Nutrition 0.000 description 8
- 239000004299 sodium benzoate Substances 0.000 description 8
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 8
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 8
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 8
- 230000003385 bacteriostatic effect Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 5
- UHXWLHYMUGRLKG-UHFFFAOYSA-N [Mg].O[Si](O)(O)O Chemical class [Mg].O[Si](O)(O)O UHXWLHYMUGRLKG-UHFFFAOYSA-N 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 5
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- 235000013305 food Nutrition 0.000 description 5
- 230000002209 hydrophobic effect Effects 0.000 description 5
- 239000013521 mastic Substances 0.000 description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 4
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 4
- 230000002045 lasting effect Effects 0.000 description 4
- HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 4
- 239000000391 magnesium silicate Substances 0.000 description 4
- 229910052919 magnesium silicate Inorganic materials 0.000 description 4
- 235000019792 magnesium silicate Nutrition 0.000 description 4
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 4
- 239000011976 maleic acid Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 3
- 241000220317 Rosa Species 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 229940041616 menthol Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 208000002064 Dental Plaque Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
- 150000003464 sulfur compounds Chemical class 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 239000008868 Flower Essence Substances 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000037123 dental health Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 238000003837 high-temperature calcination Methods 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
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- 230000036039 immunity Effects 0.000 description 1
- 229940029329 intrinsic factor Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
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- 244000000010 microbial pathogen Species 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
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- 210000003695 paranasal sinus Anatomy 0.000 description 1
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
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- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
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- 210000003296 saliva Anatomy 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
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- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention discloses night toothpaste and morning and night combination toothpaste. In the invention, the night toothpaste and morning toothpaste are packaged and combined together, wherein the morning toothpaste comprises an absorbent, an abradant, a humectant, a thickening agent, a freshener and a fragrance; and the night toothpaste comprises a grinding material, a humectant, a thickening agent, a bacteriostatic agent, a macromoleclar polymer, zinc citrate, a fragrance and a freshener. According to the oral environment change in the morning and at night on teeth, the morning and night combination toothpaste is adopted. Oral micro ecological balance can be kept, the problem of halitosis is solved, and oral smell is refreshed for a long time.
Description
Technical field
The present invention relates to field of oral care, be specifically related to the oral care composition field.
Background technology
Halitosis refers to be full of the cavity of air such as nose, nasal sinuses, pharynx from oral cavity or other, the foul smell abnormal flavour that gives out, the normal contacts that it affects people with exchange, affect social image and the mental health of self.A recent investigation shows that the sickness rate of halitosis in Chinese population reached 27.5%, and the patient that its pathogenic factor belongs to the oral cavity intrinsic factor accounts for 80 ~ 90%.Mouth source property halitosis mainly is that the volatile sulfur compounds of generation causes with the fatty acid with abnormal flavour by the corrupt materials such as sulfur-containing amino acid, peptide and protein that decompose of oral cavity bacterium.Therefore, for mouth source property halitosis can be by remove producing halitosis pathogenic microorganism and the toxin of its generation and remove directly rapidly that smelly compounds gas suppresses halitosis, fresh breath in the oral cavity.
Chinese patent CN1633970A invention contains the halitosis-removing toothpaste of multiple herbal composite, and the consumption of herbal composite is 20 ~ 40%.
People's oral environment is different round the clock, daytime normal oral cavity activity, exciting salivary secretion, oxygen concentration is high in the oral cavity, pH value raises in the feed process, and saliva can remove the residue in the food, reduces tooth bacterium and food debris and piles up; And oxygen concentration relative reduce in the night oral cavity, the salivation amount reduces, pH value is lower, the breeding of antibacterial raised growth, decompose and to remain in that the protein in the food detritus and slough tissue generates the materials such as volatile sulfur compounds, ammonia and organic acid in the tooth, the speed of growth of dental plaque is greater than daytime far away.Get up morning with evening oral environment different, also be different on the impact of tooth.Brush teeth morning and brush teeth night and use same effect toothpaste, can not the effectively preventing halitosis.According to this variation of morning and evening environment, develop respectively pure and fresh toothpaste of morning and evening and solve targetedly halitosis, make implication clear, be significant.
Sooner or later use same toothpaste, therapeutic effect does not have specific aim." can develop immunity to drugs as often eating a kind of coldrex ".Use targetedly the toothpaste of what effect because distinguishing reason and environment.The human mouth environment changes round the clock, and these dental healths that change the people have significant impact.
Summary of the invention
The object of the present invention is to provide a kind of benefit early toothpaste and the late toothpaste of a kind of benefit, according to people's oral cavity environment difference round the clock, targetedly exploitation, and packaging together, allow user sooner or later be combined with.
The object of the invention is achieved through the following technical solutions.
A kind of benefit is beneficial late combined tooth-paste early, is comprised of the beneficial early toothpaste that uses morning and the beneficial late toothpaste that uses evening;
Described benefit early raw material of toothpaste comprises modified adsorbent, abrasive material, wetting agent, thickening agent, freshener and essence; The parts by weight of each raw material are as follows:
40～48 parts in abrasive material
28～40 parts of wetting agents
0.2～1.4 part of thickening agent
1.0～2.0 parts in essence
1.0～5.0 parts of modified adsorbents
0.3 ~ 1.0 part of modification freshener;
The late toothpaste of described benefit, the parts by weight of raw material are as follows:
15～25 parts in abrasive material
50～73 parts of wetting agents
0.3～1.2 part of thickening agent
0.05～2.0 part of antibacterial
0.05 ~ 2.0 part of high molecular polymer
0.05 ~ 2.0 part of zinc citrate
1.0 ~ 2.0 parts in essence
0.3 ~ 1.0 part of modification freshener.
Described modified adsorbent is that adsorbent is used first acid soak 3 ~ 4h, after the filtration, at 800～850 ℃ of calcining 3 ~ 8h, crosses 400 mesh sieves after the cooling again.Adsorbent can be aluminium oxide, silica gel, silicate or molecular sieve.
Described modification freshener is that freshener is dissolved in the ethanol, adds the alcoholic solution of the silicate of 0.5mol/L again, stirs to make it abundant mixing, add again deionized water, silicate begins hydrolysis, forms gradually hydrogel, the freshener that parcel is separated out, after being hydrolyzed, ageing, centrifugalize goes out solid, namely obtains modification freshener wet feed, with wet feed filter pressing, vacuum drying, obtain the modification freshener.
Described benefit toothpaste morning and beneficial late toothpaste can also comprise pyrophosphate, and parts by weight are 0.2～2.0 part.
Described benefit toothpaste morning and beneficial late toothpaste can also comprise surfactant, and parts by weight are 1.5～2.5 parts.
Described high molecular polymer is that the molecule long-chain is hydrophobic aliphatic chain or fragrant chain, side chain is the high molecular polymer of polar group, and it is composite to be selected from polyvinylpyrrolidone, vinyl methyl ether/copolymer-maleic anhydride, acrylic copolymer or the fatty alcohol-polyoxyethylene ether one or more.Described high molecular polymer is vinyl methyl ether/copolymer-maleic anhydride particularly preferably, and parts by weight are 0.05 ~ 2.0 part.
Another object of the present invention is to provide a kind of benefit late toothpaste, the parts by weight of raw material are as follows:
15～25 parts in abrasive material
50～73 parts of wetting agents
0.7～1.2 part of thickening agent
0.05～2.0 part of antibacterial
0.05 ~ 2.0 part of high molecular polymer
0.05 ~ 2.0 part of zinc citrate
1.0 ~ 2.0 parts in essence
0.3 ~ 1.0 part of freshener.
Described high molecular polymer is that the molecule long-chain is hydrophobic aliphatic chain or fragrant chain, side chain is the high molecular polymer of polar group, and it is composite to be selected from polyvinylpyrrolidone, vinyl methyl ether/copolymer-maleic anhydride, acrylic copolymer or the fatty alcohol-polyoxyethylene ether one or more.Described high molecular polymer is vinyl methyl ether/copolymer-maleic anhydride particularly preferably, and parts by weight are 0.05 ~ 2.0 part.
Can also comprise pyrophosphate, parts by weight are 0.2～2.0 part, also comprise surfactant, and parts by weight are 1.5～2.5 parts.
Described modification freshener is that freshener is dissolved in the ethanol, adds the alcoholic solution of the silicate of 0.5mol/L again, stirs to make it abundant mixing, add again deionized water, silicate begins hydrolysis, forms gradually hydrogel, the freshener that parcel is separated out, after being hydrolyzed, ageing, centrifugalize goes out solid, namely obtains modification freshener wet feed, with wet feed filter pressing, vacuum drying, obtain the modification freshener.
Get up morning, contains the gas with foreign flavor that night, bacterial decomposition produced in the oral cavity, and at early toothpaste interpolation of benefit adsorbent, these gas with foreign flavor in the absorption oral cavity make toothpaste have the effect that can remove very soon halitosis.Described adsorbent is to cross through special PROCESS FOR TREATMENT, the height that its specific activity was not processed.The specific surface area of the adsorbent of process activation processing increases, and the hole internal diameter increases, active increasing, adsorption efficiency raising.
In benefit toothpaste morning, add the modification freshener in the employed essence, improved the mouthfeel of essence and the endurance of refrigerant sense, and the use of collocation surfactant, can in the oral cavity, disperse very soon, make whole oral cavity be full of refrigerant sense and lasting.
Described essence can be the pure and fresh fragrance of a flower such as rose essence, Flos Nelumbinis essence, Bulbus Lilii essence, jasmine flower essence, lavandula angustifolia essence.
Having added long-chain in the late toothpaste of benefit is hydrophobic aliphatic chain or fragrant chain, and side chain is the high molecular polymer of polar group, and this high molecular polymer can the complexation antibacterial, and the long-acting oral cavity microecological balance of keeping suppresses the halitosis bacterial reproduction.Behind this high molecular polymer complexation antibacterial, reduce the antibacterial rate of release, prolonged the antibacterial time.
Antibacterial is to contain strong polar group low molecular compound on the molecular structure, can be sequestered in by intermolecular captivation with high molecular polymer.Under the protection of high molecular polymer; performance bacteriostasis that can be more lasting; prevent halitosis, described antibacterial can be selected one or both the composite uses in cetylpyridinium chloride, chlorhexidine, triclosan, the dodecyl dimethyl benzyl ammonium chloride.
Selecting the molecule long-chain is hydrophobic aliphatic chain or fragrant chain, side chain is the high molecular polymer of polar group, and molecular structure contains hydrophobic bond and hydrophilic polar key simultaneously, has the character of hydrophilic and oleophilic, can from different chemical compound complexations, with the low molecular compound complexation on its strand.This side chain of while is that the high molecular polymer polar group of polar group can be combined with hydroxyapatite, be adsorbed on the surface of tooth, hydrophobic group is exposed to the outside, with water resistance every outside, prevent that antibacterial is washed away, improve the action time of antibacterial, thus the long-acting oral cavity microecological balance of keeping.
After benefit has been added the compositions of composite vinyl methyl ether/copolymer-maleic anhydride and zinc citrate-late factor of NFD benefit in the late toothpaste especially, copolymer forms biomembrane at dental surface, antibacterial and zinc citrate are slowly discharged, and vinyl methyl ether/copolymer-maleic anhydride Gantrez AN-119 and zinc citrate have good synergisticing performance.Stop the effect of halitosis, nutrition gingiva, antibacterial dental plaque slowly to discharge thereby make, make the oral cavity be in long guard mode, make implication pure and fresh lastingly, and two kinds of compositions are all safe, gentle, and human body is had no side effect.
Benefit early preferably is done abrasive material through the crystal calcium carbonate of polishing in the toothpaste, and crystal neatly, epigranular, particle surface are mellow and full has good frictional behaviour simultaneously, is unlikely to excessively to injure tooth in cleaning teeth.Select crystal calcium carbonate to do abrasive material, the pH value of mastic is controlled at 8.0 ~ 9.0, is alkalescence, can in and the acidic materials in the oral cavity, prevent that anaerobic bacteria was decomposed acidoid and stopped for a long time night on tooth, keep oral environment.
In the late toothpaste of benefit, add zinc citrate can with dentin and skeleton in the calcium ion complex; the citric acid complex that generates has the effect of protection and sealing; under the effect of polyhydric alcohol wetting agent; may penetrate in the dentin and go; lengthen the time of staying of nutrition; with the composite use of pyrophosphate, can make remineralization of teeth.
Preferred silicon dioxide has good frictional force as rubbing material in the late toothpaste of benefit, and improves the dispersibility of toothpaste, improves mouthfeel, makes toothpaste have preferably fragrance when brushing teeth.
Advantage and beneficial effect that the present invention has with respect to prior art:
(1) according to the impact of morning and evening oral environment variation on tooth, exploitation is beneficial early, beneficial late combined tooth-paste is takeed good care of teeth for different oral environments, keeps the oral cavity microecological balance, and the solution problem of bad breath makes implication pure and fresh lastingly.
(2) high molecular polymer can the complexation antibacterial, and the long-acting oral cavity microecological balance of keeping suppresses the halitosis bacterial reproduction.In the late toothpaste of benefit, add the NFD active factors; Benefit is early used pure and fresh floral perfume in the toothpaste, and fragrance is full, pure and fresh.
(3) NFD active factors and antibacterial screening in the beneficial late toothpaste, proportioning, benefit be the kind of essence in the toothpaste, consumption and all select through creative work with the ratio of freshener early, has solved the problem of halitosis, makes the oral cavity keep lasting delicate fragrance.
The specific embodiment
Embodiment 1
A, benefit be pure and fresh toothpaste early
It is as follows to fill a prescription:
100 parts
Sorbitol: 18
Glycerol: 15
CMC：?0.5
HANSHENGJIAO: 0.4
Crystal calcium carbonate: 48
Saccharin sodium: 0.25
Sodium benzoate: 0.2
Tetrasodium pyrophosphate: 0.4
Sodium lauroyl sarcosine: 2.3
Activated silicic acid magnesium: 4.0
Rose essence: 1.0
Modification freshener: 0.3
Pigment: 0.05
Deionized water: surplus
Modified adsorbent is selected activated silicic acid magnesium, takes by weighing the food grade magnesium silicate of certain mass, and it is used phosphoric acid dip 3h, afterwards filtration, drying.The magnesium silicate that drying is good was calcined 4 hours in 800 ℃ of high temperature, was cooled to afterwards room temperature, crossed 400 mesh sieves, as the adsorbent in the toothpaste.
Described modification freshener is that menthol is dissolved in the ethanol, adds the alcoholic solution of the silicate of 0.5mol/L again, stirs to make it abundant mixing, add again deionized water, silicate begins hydrolysis, forms gradually hydrogel, the freshener that parcel is separated out, after being hydrolyzed, ageing, centrifugalize goes out solid, namely obtains modification menthol wet feed, with wet feed filter pressing, vacuum drying, obtain the modification menthol.
Preparation technology is as follows:
(1) sodium benzoate, tetrasodium pyrophosphate and saccharin sodium are added in the container 1, add entry and stirring;
(2) whole wetting agents and rubber powder are joined in the container 2, the aqueous mixtures in the step 1 is added in the container 2;
(3) with said mixture with after abrasive material, activated silicic acid magnesium, modification freshener, sodium lauroyl sarcosine mix, mixed at high speed is 15 to 20 minutes under vacuum;
(4) with pigment with water dissolution after, join in the said mixture;
(5) add at last essence and under vacuum, fully mix, disperse, last degassed formation mastic.
B, the new toothpaste of beneficial late Qing Dynasty
100 parts
Sorbitol: 48 parts
Glycerol: 25 parts
CMC:0.3 part
HANSHENGJIAO: 0.4 part
Silicon dioxide: 15 parts
Saccharin sodium: 0.2 part
Sodium benzoate: 0.2 part
Tetrasodium pyrophosphate: 0.2 part
Sodium lauroyl sarcosine: 2.0 parts
Cetylpyridinium chloride: 0.1 part
Vinyl methyl ether/maleic acid: 1.0 parts
Zinc citrate: 0.05 part
The pure and fresh essence of Herba Menthae: 1.0 parts
Mentholum: 0.3 part
Pigment: 0.02 part
Deionized water: surplus
Preparation technology is as follows:
(1) sodium benzoate, zinc citrate, tetrasodium pyrophosphate, cetylpyridinium chloride and saccharin sodium are added in the container 1, add entry and stirring;
(2) whole wetting agents and rubber powder, vinyl methyl ether/maleic acid are joined in the container 2, the aqueous mixtures in the step 1 is added in the container 2;
(3) with said mixture with after abrasive material, freshener, sodium lauroyl sarcosine mix, mixed at high speed is 15 to 20 minutes under vacuum;
(4) with pigment with water dissolution after, join in the said mixture;
(5) add at last essence and under vacuum, fully mix, disperse, last degassed formation mastic.
Embodiment 2
A, benefit be pure and fresh toothpaste early
100 parts, it is as follows to fill a prescription
Sorbitol: 25
Glycerol: 10
CMC：?0.6
HANSHENGJIAO: 0.4
Crystal calcium carbonate: 40
Saccharin sodium: 0.2
Sodium benzoate: 0.2
Tetrasodium pyrophosphate: 0.6
Sodium lauroyl sarcosine: 2.5
Activated silicic acid magnesium: 5.0
Rose essence: 1.0
Modification freshener: 0.3
Pigment: 0.04
Deionized water: surplus
Take by weighing the food grade magnesium silicate of certain mass, it is used phosphoric acid dip 3h, afterwards filtration, drying.The magnesium silicate that drying is good high-temperature calcination in 800 ℃ of air atmospheres is cooled to room temperature afterwards, crosses 400 mesh sieves, as the adsorbent in the toothpaste.
Described modification freshener is that menthyl lactate and Mentholum are dissolved in the ethanol together, adds the alcoholic solution of the silicate of 0.5mol/L again, stirs to make it abundant mixing, add again deionized water, silicate begins hydrolysis, forms gradually hydrogel, the freshener that parcel is separated out, after being hydrolyzed, ageing, centrifugalize goes out solid, namely obtains modification freshener wet feed, with wet feed filter pressing, vacuum drying, obtain the modification freshener.
Preparation technology is as follows:
(1) sodium benzoate, tetrasodium pyrophosphate and saccharin sodium are added in the container 1, add entry and stirring;
(2) whole wetting agents and rubber powder are joined in the container 2, the aqueous mixtures in the step 1 is added in the container 2;
(3) with said mixture with after abrasive material, activated silicic acid magnesium, modification freshener, sodium lauroyl sarcosine mix, mixed at high speed is 15 to 20 minutes under vacuum;
(4) with pigment with water dissolution after, join in the said mixture;
(5) add at last essence and under vacuum, fully mix, disperse, last degassed formation mastic.
B, the new toothpaste of beneficial late Qing Dynasty
100 parts of total amounts:
Sorbitol: 40
Glycerol: 20
CMC：0.5
HANSHENGJIAO: 0.7
Silicon dioxide: 23
Saccharin sodium: 0.3
Sodium benzoate: 0.3
Tetrasodium pyrophosphate: 0.6
Sodium lauroyl sarcosine: 2.5
Cetylpyridinium chloride: 0.3
Vinyl methyl ether/maleic acid: 1.5
Zinc citrate: 2.0
The pure and fresh essence of Herba Menthae: 1.5
Modification terpane formyl ethamine: 0.3
Pigment: 0.04
Deionized water: surplus
Described modification freshener is that terpane formyl ethamine is dissolved in the ethanol, adds the alcoholic solution of the silicate of 0.5mol/L again, stirs to make it abundant mixing, add again deionized water, silicate begins hydrolysis, forms gradually hydrogel, the freshener that parcel is separated out, after being hydrolyzed, ageing, centrifugalize goes out solid, namely obtains modification terpane formyl ethamine wet feed, with wet feed filter pressing, vacuum drying, obtain modification terpane formyl ethamine.
Preparation technology is as follows:
(1) sodium benzoate, zinc citrate, tetrasodium pyrophosphate, cetylpyridinium chloride and sweeting agent (for example saccharin sodium) are added in the container 1, add entry and stirring;
(2) whole wetting agents and rubber powder, vinyl methyl ether/maleic acid are joined in the container 2, the aqueous mixtures in the step 1 is added in the container 2;
(3) with said mixture with after abrasive material, modification freshener, sodium lauroyl sarcosine mix, mixed at high speed is 15 to 20 minutes under vacuum;
(4) with pigment with water dissolution after, join in the said mixture;
(5) add at last essence and under vacuum, fully mix, disperse, last degassed formation mastic.
Embodiment 3
The toothpaste of embodiment 1 is carried out bacteriostatic experiment, and effect data is as follows:
1, embodiment 1 benefit toothpaste morning is carried out bacteriostatic experiment, the result is as follows:
Embodiment 1 benefit is 5 minutes quick bacteriostatic experiment results of toothpaste early
2, embodiment 1 benefit is carried out bacteriostatic experiment evening, the result is as follows:
12 hours lasting bacteriostatic experiment results of embodiment 1 beneficial late toothpaste
Benefit toothpaste morning of embodiment 1 and the result that beneficial late toothpaste carries out bacteriostatic experiment show that benefit toothpaste morning is anti-bacteria fast, and reduction is active; And the long-acting oral cavity ecological balance of keeping of beneficial late toothpaste energy suppresses the halitosis bacterial reproduction.Change the benefit morning that the impact of tooth is invented, beneficial late toothpaste according to the morning and evening oral environment, can suppress halitosis bacterial reproduction in the oral cavity, make breath freshening.
The according to the above description announcement of book and instruction, those skilled in the art in the invention can also change and revise above-mentioned embodiment.Therefore, the specific embodiment that discloses and describe above the present invention is not limited to also should fall in the protection domain of claim of the present invention modifications and changes more of the present invention.In addition, although used some specific terms in this description, these terms do not consist of any restriction to the present invention just for convenience of description.
Claims (3)
1. benefit beneficial late combined tooth-paste morning is characterized in that, is comprised of the beneficial late toothpaste of use in evening and the beneficial early toothpaste that uses morning;
The described benefit early raw material of toothpaste comprises modified adsorbent, abrasive material, wetting agent, thickening agent, freshener and essence; The parts by weight of raw material are as follows:
The parts by weight of the raw material that the late toothpaste of described benefit comprises are as follows:
Described modified adsorbent is that adsorbent is used first acid soak 3 ~ 4h, after the filtration, at 800～850 ℃ of calcining 3 ~ 8h, crosses 400 mesh sieves after the cooling again; Described adsorbent is aluminium oxide, silica gel, silicate or molecular sieve;
Described high molecular polymer is that in polyvinylpyrrolidone, acrylic copolymer or the fatty alcohol-polyoxyethylene ether one or more are composite;
Described antibacterial is one or both in cetylpyridinium chloride, chlorhexidine, the dodecyl dimethyl benzyl ammonium chloride;
Described modification freshener is that freshener is dissolved in the ethanol, adds the alcoholic solution of the silicate of 0.5mol/L again, stirs to make it abundant mixing, add again deionized water, silicate begins hydrolysis, forms gradually hydrogel, the freshener that parcel is separated out, after being hydrolyzed, ageing, centrifugalize goes out solid, namely obtains modification freshener wet feed, with wet feed filter pressing, vacuum drying, obtain the modification freshener.
2. a kind of benefit beneficial late combined tooth-paste morning according to claim 1 is characterized in that described benefit toothpaste morning and beneficial late toothpaste also comprise pyrophosphate, and parts by weight are 0.2～2.0 part.
3. late toothpaste of benefit is characterized in that the parts by weight of raw material are as follows:
Described high molecular polymer is that in polyvinylpyrrolidone, acrylic copolymer or the fatty alcohol-polyoxyethylene ether one or more are composite;
Described antibacterial is one or both in cetylpyridinium chloride, chlorhexidine, the dodecyl dimethyl benzyl ammonium chloride;
Described modification freshener is that freshener is dissolved in the ethanol, adds the alcoholic solution of the silicate of 0.5mol/L again, stirs to make it abundant mixing, add again deionized water, silicate begins hydrolysis, forms gradually hydrogel, the freshener that parcel is separated out, after being hydrolyzed, ageing, centrifugalize goes out solid, namely obtains modification freshener wet feed, with wet feed filter pressing, vacuum drying, obtain the modification freshener.
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| CN 201210005858 CN102512337B (en) | 2012-01-10 | 2012-01-10 | Night toothpaste and morning and night combination toothpaste |
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| CN 201210005858 CN102512337B (en) | 2012-01-10 | 2012-01-10 | Night toothpaste and morning and night combination toothpaste |
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| CN105168059B (en) * | 2015-09-24 | 2017-12-26 | 名臣健康用品股份有限公司 | A kind of benefit good night refreshing Chinese medicinal toothpaste |
| CN106491390B (en) * | 2016-12-13 | 2019-09-03 | 美晨集团股份有限公司 | A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid and preparation method thereof |
| CN106511112B (en) * | 2016-12-13 | 2019-10-18 | 美晨集团股份有限公司 | A kind of persistently refrigerant antibacterial toothpaste and preparation method thereof |
| CN107028779B (en) * | 2017-03-13 | 2021-02-19 | 广州舒客实业有限公司 | Toothpaste containing algefacient composition |
| CN111973535B (en) * | 2020-09-10 | 2023-08-08 | 李时珍国灸集团蕲艾产业(蕲春)有限公司 | Mugwort leaf washing-free disinfection gel and preparation method thereof |
| CN112353709A (en) * | 2020-11-04 | 2021-02-12 | 广州市盛龙口腔清洁用品有限公司 | Toothpaste compounded with mint freshener |
| CN115944572A (en) * | 2023-02-07 | 2023-04-11 | 湖南天华医药生物科技有限公司 | Toothpaste based on nutgall extract and preparation method thereof |
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| SE512333C2 (en) * | 1989-08-25 | 2000-02-28 | Colgate Palmolive Co | Antibacterial oral composition with plaque- and tartar-limiting action |
| DE3928063A1 (en) * | 1989-08-25 | 1991-02-28 | Henkel Kgaa | ANTI-COATING TOOTHPASTE |
| CN1361044A (en) * | 2000-12-25 | 2002-07-31 | 王文新 | Soft tubular packing bag |
| CN101372443B (en) * | 2008-09-27 | 2011-06-08 | 广州薇美姿个人护理用品有限公司 | Composite modifying method of menthol and derivative thereof |
| BRPI0924652B1 (en) * | 2009-04-01 | 2016-11-22 | Colgate Palmolive Co | toothpaste composition and use of at least one material |
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