CN108403453A - A kind of toothpaste containing phosphosilicate glass - Google Patents
A kind of toothpaste containing phosphosilicate glass Download PDFInfo
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- CN108403453A CN108403453A CN201810531124.0A CN201810531124A CN108403453A CN 108403453 A CN108403453 A CN 108403453A CN 201810531124 A CN201810531124 A CN 201810531124A CN 108403453 A CN108403453 A CN 108403453A
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- Prior art keywords
- toothpaste
- phosphosilicate glass
- glass
- phosphorus
- sodium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to household chemicals technical fields, and in particular to a kind of toothpaste containing phosphosilicate glass, the toothpaste include phosphosilicate glass, moisturizer, rubbing agent, adhesive, surfactant, sweetener and essence.The invention discloses it is a kind of containing high stripping property, stablize pH value phosphosilicate glass toothpaste.The phosphosilicate glass of the present invention has quick mineralization ability in saliva of buccal cavity, several genes can be promoted to express, and promote the formation of growth factor.So as to：(1) tooth wound is repaired, hypersensitive dentin, the generation of pre- anti-caries are alleviated；(2) inhibit bleeding gums, slow down periodontitis etc.；(3) prevent or treat canker sore；(4) it repairs cementum to absorb, has and release tooth mobility and other effects；(5) prevent or treat sensitivity of tooth.
Description
Technical field
The invention belongs to household chemicals technical fields, and in particular to a kind of toothpaste containing phosphosilicate glass.
Background technology
With the improvement of people ' s living standards and to the pay attention to day by day of oral health, the demand to toothpaste is via common clear
Clean type develops to curative effect-type.
Bio-vitric is a kind of bioactive materials, after being implanted into body fluid, can discharge ion (such as Ca2+、Na+), in material
Surface forms SiO2Layer of silica gel, then Ca2+And PO4 3-Depositing crystalline forms hydroxyapatite in layer of silica gel, uses it for tooth
Have effects that centainly to prevent and alleviate hemodia in cream.But it is made of, poor toughness, is brushing teeth minerals entirely due to repairing position
It still can fall off in friction process, it is difficult to solve the problems, such as hemodia and injury of teeth in itself.Patent document
CN103006529B discloses bioactivity glass combination hydroxyapatite and tricalcium phosphate etc. to improve its bioactivity, obtains
The toothpaste of saprodontia lesion can be terminated.Patent document CN104207960A discloses a kind of containing bioactivity glass/chitosan
Toothpaste, with antibacterial anti-inflammatory and other effects.
But current toothpaste there are problems that tooth body itself cannot be promoted to repair.
Invention content
In view of the deficiencies of the prior art, the object of the present invention is to provide a kind of toothpaste containing phosphosilicate glass,
The toothpaste can effectively prevent and repair, treat the problems of tooth, such as repair tooth wound, alleviate hypersensitive dentin, is pre-
Anti-caries inhibit bleeding gums, slow down periodontitis, prevention or treatment canker sore, repair cementum absorption, release tooth pine
Dynamic, prevention or treatment sensitivity of tooth, etc..
The purpose of the invention is achieved by the following technical solution：
A kind of toothpaste containing phosphosilicate glass, including phosphosilicate glass, moisturizer, rubbing agent, adhesive, surface
Activating agent, sweetener and essence.
Can also include water according to the present invention, in the toothpaste.
According to the present invention, the mass percent of each component can be in the toothpaste：Moisturizer 35-95%, rubbing agent 1-
22%, adhesive 1-7%, surfactant 0.5-4.5%, sweetener 0.05-1.85%, phosphosilicate glass 1-41% are fragrant
Smart 0.05-1.65%, water 0-12%；
Preferably, the mass percent of each component can be in the toothpaste：Moisturizer 40-90%, rubbing agent 3-20%,
Adhesive 2-6%, surfactant 1-4%, sweetener 0.1-1.8%, phosphosilicate glass 2-40%, essence 0.1-1.6%,
Water 0-10%.
Can also include other active additives and/or aromatic according to the present invention, in the toothpaste.
According to the present invention, the mass percent of other active additives is 0-20%, preferably 0-10%；The fragrance
The mass percent of agent is 0-5%, preferably 0-2%.
Further, the phosphosilicate glass knows any suitable for system of the present invention for those skilled in the art
Phosphosilicate glass, the phosphosilicate glass includes metal oxide and nonmetal oxide, wherein the non-gold
It can be SiO to belong to oxide2And P2O5, the metal oxide is one kind or several in the oxides such as calcium, strontium, magnesium, zinc, sodium, potassium
Kind.
Further, the SiO2Content be 40-60wt%, the P2O5Content be 15-30wt%, remaining for gold
Belong to oxide and inevitable impurity；The sum of each component content is 100wt% in the phosphosilicate glass.
According to the present invention, the phosphosilicate glass can be selected from phosphorus calsil glass, phosphorus silicic acid strontium glass, phosphorus silicic acid
It is one or more in magnesium glass, phosphorus water soda glass, phosphorus zinc silicate glass.
Further, one or more (two kinds in glycerine, propylene glycol, polyethylene glycol, sorbierite of the moisturizer
Or two or more).
Further, the rubbing agent is selected from calcium carbonate, calcium bicarbonate, calcium pyrophosphate, silicic acid hydrate, silica, hydrogen
One or more (two or more) in aluminium oxide, pearl powder, titanium dioxide.
Further, described adhesive is selected from carbomer, poloxamer, sodium carboxymethylcellulose and its derivative, hydroxypropyl
In base guar gum, xanthans, carragheen, carbomer, Irish moss, sodium alginate it is one or more (two kinds or two kinds with
On).
Further, the surfactant is in lauryl sodium sulfate, sodium lauryl sulfate, sldium lauryl sulfate
One kind, two or three.
Further, one or more (two kinds in saccharin sodium, Aspartame, sucrose, xylitol of the sweetener
Or two or more).
Further, other described active additives can be selected from bioactivity glass, hydroxyapatite or tricalcium phosphate
At least one.
Further, the aromatic can be selected from pennyroyal or fruits essence.
Beneficial effects of the present invention
The invention discloses it is a kind of containing high stripping property, stablize pH value phosphosilicate glass toothpaste.The phosphorus of the present invention
Silicate glass has quick mineralization ability in saliva of buccal cavity, several genes can be promoted to express, and promote growth factor
It is formed.So as to：(1) tooth wound is repaired, hypersensitive dentin, the generation of pre- anti-caries are alleviated；(2) inhibit bleeding gums,
Slow down periodontitis etc.；(3) prevent or treat canker sore；(4) it repairs cementum to absorb, has and release tooth mobility and other effects；
(5) prevent or treat sensitivity of tooth.
Description of the drawings
Fig. 1 is that phosphorus calcic silicate glass deposits front and back XRD diagram in artificial saliva.
Fig. 2, which is phosphorus calcic silicate glass, can more preferably promote pulp cells at tooth differentiation figure.
Fig. 3 is the SEM figures that toothpaste brushes after dentine in embodiment 2.
Fig. 4 is the SEM figures that toothpaste brushes after dentine in embodiment 3.
Fig. 5 is the SEM figures that toothpaste brushes after dentine in embodiment 4.
Fig. 6 is the SEM figures that toothpaste brushes after dentine in embodiment 5.
Specific implementation mode
Further detailed description is done to the present invention below in conjunction with specific embodiment.It should be appreciated that the following example
It is merely illustrative the ground description and interpretation present invention, and is not necessarily to be construed as limiting the scope of the invention.It is all to be based on this hair
In the range of the technology that bright the above is realized is encompassed by the present invention is directed to protect.
Unless otherwise indicated, the raw materials and reagents used in following embodiment are commercial goods, or can be by
It is prepared by perception method.
Embodiment 1
Phosphorus calcic silicate glass formation that can promote mineralized layer in 1 day in artificial saliva, as shown in Figure 1, with traditional
45S5 glass breaks up at tooth compared to can advantageously promote pulp cells, as shown in Fig. 2, can promote growth factor simultaneously
It generates.It is introduced into toothpaste, tooth wound can be repaired, inhibit bleeding gums, slow down periodontitis etc..
Embodiment 2
A kind of toothpaste containing phosphosilicate glass, the weight percent of wherein each component are：Glycerine 40%, silicic acid hydrate
12%, sodium carboxymethylcellulose 6%, phosphorus calcic silicate glass 40%, lauryl sodium sulfate 1%, xylitol 0.5%, essence
0.5%.
The toothpaste of preparation is brushed into 5min dentin layer surface (impregnating 12h in artificial saliva), then manually saliva
It rinses, dries.By SEM observations it can be seen that there is the formation of a large amount of mineralized layers in dentin surface, as shown in Figure 3.
Embodiment 3
A kind of toothpaste containing phosphosilicate glass, the weight percent of wherein each component are：Glycerine 50%, polyethylene glycol
10%, silica 8%, carbomer 2%, phosphorus silicic acid strontium glass 25%, sodium lauryl sulfate 1%, saccharin sodium 0.1%, essence
0.9%, deionized water 3%.
The toothpaste of preparation is brushed into 5min dentin layer surface (impregnating 12h in artificial saliva), then manually saliva
It rinses, dries.By SEM observations it can be seen that there is the formation of mineralized layer in dentin surface, as shown in Figure 4.
Embodiment 4
A kind of toothpaste containing phosphosilicate glass, the weight percent of wherein each component are：Glycerine 60%, polyethylene glycol
20%, titanium dioxide 5%, xanthans 2%, phosphorus magnesium silicate glass 10%, sldium lauryl sulfate 2%, xylitol 0.5%, essence
0.5%.
The toothpaste of preparation is brushed into 5min dentin layer surface (impregnating 12h in artificial saliva), then manually saliva
It rinses, dries.By SEM observations it can be seen that there is the formation of a small amount of mineralized layer in dentin surface, as shown in Figure 5.
Embodiment 5
A kind of toothpaste containing phosphosilicate glass, the weight percent of wherein each component are：Glycerine 60%, polyethylene glycol
30%, calcium carbonate 4%, carragheen 2%, phosphorus zinc silicate glass 2%, lauryl sodium sulfate 1%, sucrose 0.5%, essence
0.5%.
The toothpaste of preparation is brushed into 5min dentin layer surface (impregnating 12h in artificial saliva), then manually saliva
It rinses, dries.By SEM observations it can be seen that there is the formation of a small amount of mineralized layer in dentin surface, as shown in Figure 6.
More than, embodiments of the present invention are illustrated.But the present invention is not limited to the above embodiments.It is all
Within the spirit and principles in the present invention, any modification, equivalent substitution, improvement and etc. done should be included in the guarantor of the present invention
Within the scope of shield.
Claims (10)
1. a kind of toothpaste containing phosphosilicate glass, which is characterized in that the toothpaste include phosphosilicate glass, moisturizer,
Rubbing agent, adhesive, surfactant, sweetener and essence.
2. toothpaste according to claim 1, which is characterized in that can also include water in the toothpaste.
3. toothpaste according to claim 1 or 2, which is characterized in that the mass percent of each component can be in the toothpaste
For：Moisturizer 35-95%, rubbing agent 1-22%, adhesive 1-7%, surfactant 0.5-4.5%, sweetener 0.05-
1.85%, phosphosilicate glass 1-41%, essence 0.05-1.65%, water 0-12%.
4. according to claim 1-3 any one of them toothpaste, which is characterized in that the mass percent of each component in the toothpaste
Can be：Moisturizer 40-90%, rubbing agent 3-20%, adhesive 2-6%, surfactant 1-4%, sweetener 0.1-
1.8%, phosphosilicate glass 2-40%, essence 0.1-1.6%, water 0-10%.
5. according to claim 1-4 any one of them toothpaste, which is characterized in that can also include other activity in the toothpaste
Additive and/or aromatic；
Preferably, the mass percent of other active additives is 0-20%, preferably 0-10%；The quality of the aromatic
Percentage is 0-5%, preferably 0-2%.
6. according to claim 1-5 any one of them toothpaste, which is characterized in that the phosphosilicate glass includes metal oxidation
Object and nonmetal oxide, wherein the nonmetal oxide can be SiO2And P2O5, the metal oxide be calcium, strontium,
One or more of oxides such as magnesium, zinc, sodium, potassium；
Preferably, the SiO2Content be 40-60wt%, the P2O5Content be 15-30wt%, remaining for metal oxidation
Object and inevitable impurity；The sum of each component content is 100wt% in the phosphosilicate glass.
7. according to claim 1-6 any one of them toothpaste, which is characterized in that the phosphosilicate glass can be selected from phosphorus silicon
It is one or more in acid calcium salt glass, phosphorus silicic acid strontium glass, phosphorus magnesium silicate glass, phosphorus water soda glass, phosphorus zinc silicate glass.
8. according to claim 1-7 any one of them toothpaste, which is characterized in that the moisturizer is selected from glycerine, propylene glycol, gathers
One or more (two or more) in ethylene glycol, sorbierite；
Preferably, the rubbing agent be selected from calcium carbonate, calcium bicarbonate, calcium pyrophosphate, silicic acid hydrate, silica, aluminium hydroxide,
One or more (two or more) in pearl powder, titanium dioxide.
9. according to claim 1-8 any one of them toothpaste, which is characterized in that described adhesive is selected from carbomer, Bo Luosha
Nurse, sodium carboxymethylcellulose and its derivative, hydroxypropyl guar gum, xanthans, carragheen, carbomer, Irish moss, alginic acid
One or more (two or more) in sodium；
Preferably, the surfactant in lauryl sodium sulfate, sodium lauryl sulfate, sldium lauryl sulfate one
It plants, two or three；
Preferably, one or more (two kinds or two kinds in saccharin sodium, Aspartame, sucrose, xylitol of the sweetener
More than).
10. according to claim 5-9 any one of them toothpaste, which is characterized in that other described active additives are optional spontaneous
At least one of object activity glass, hydroxyapatite or tricalcium phosphate；
Preferably, the aromatic can be selected from pennyroyal or fruits essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810531124.0A CN108403453A (en) | 2018-05-29 | 2018-05-29 | A kind of toothpaste containing phosphosilicate glass |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810531124.0A CN108403453A (en) | 2018-05-29 | 2018-05-29 | A kind of toothpaste containing phosphosilicate glass |
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| Publication Number | Publication Date |
|---|---|
| CN108403453A true CN108403453A (en) | 2018-08-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810531124.0A Pending CN108403453A (en) | 2018-05-29 | 2018-05-29 | A kind of toothpaste containing phosphosilicate glass |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112999100A (en) * | 2021-02-26 | 2021-06-22 | 佛山市诺晟生物科技有限公司 | Anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860973A (en) * | 2012-10-22 | 2013-01-09 | 陈永安 | Toothpaste for repairing damaged tooth |
| EP3175835A1 (en) * | 2015-12-04 | 2017-06-07 | Omya International AG | Oral care composition for remineralisation and whitening of teeth |
| CN107235634A (en) * | 2017-07-06 | 2017-10-10 | 江西草珊瑚口腔护理用品有限公司 | A kind of biological activated glass ceramic material and preparation method thereof and a kind of toothpaste |
-
2018
- 2018-05-29 CN CN201810531124.0A patent/CN108403453A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860973A (en) * | 2012-10-22 | 2013-01-09 | 陈永安 | Toothpaste for repairing damaged tooth |
| EP3175835A1 (en) * | 2015-12-04 | 2017-06-07 | Omya International AG | Oral care composition for remineralisation and whitening of teeth |
| CN107235634A (en) * | 2017-07-06 | 2017-10-10 | 江西草珊瑚口腔护理用品有限公司 | A kind of biological activated glass ceramic material and preparation method thereof and a kind of toothpaste |
Non-Patent Citations (2)
| Title |
|---|
| 胡庆: "用于牙髓损伤修复的新型微纳米生物活性玻璃的仿生制备及性能研究", 《中国博士学位论文全文数据库医药卫生科技辑》 * |
| 车晨等: "生物活性玻璃生物学特性的研究进展", 《内蒙古农业大学学报( 自然科学版)》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112999100A (en) * | 2021-02-26 | 2021-06-22 | 佛山市诺晟生物科技有限公司 | Anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass |
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Application publication date: 20180817 |