CN107235634A - A kind of biological activated glass ceramic material and preparation method thereof and a kind of toothpaste - Google Patents
A kind of biological activated glass ceramic material and preparation method thereof and a kind of toothpaste Download PDFInfo
- Publication number
- CN107235634A CN107235634A CN201710547963.7A CN201710547963A CN107235634A CN 107235634 A CN107235634 A CN 107235634A CN 201710547963 A CN201710547963 A CN 201710547963A CN 107235634 A CN107235634 A CN 107235634A
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- China
- Prior art keywords
- ceramic material
- glass ceramic
- toothpaste
- biological activated
- present
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C10/00—Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition
- C03C10/0009—Devitrified glass ceramics, i.e. glass ceramics having a crystalline phase dispersed in a glassy phase and constituting at least 50% by weight of the total composition containing silica as main constituent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C1/00—Ingredients generally applicable to manufacture of glasses, glazes, or vitreous enamels
Abstract
The invention provides a kind of biological activated glass ceramic material and preparation method thereof and a kind of toothpaste.The biological activated glass ceramic material that the present invention is provided, includes Na2O15~30 part；CaO15~45 part；SiO225~55 parts；P2O55~25 parts；Zn0.5~2.5；Sn0.5~3.0 part.The biological activated glass ceramic material that the present invention is provided can fast deposition class bone sample phosphorus lime, during cleaning one's teeth in addition to anti-dental sensitivity, also with promote dental surface remineralization effect.When the additive for toothpaste, it can effectively prevent dental decayed tooth.
Description
Technical field
The present invention relates to glass ceramics technical field, more particularly to a kind of biological activated glass ceramic material and its preparation side
Method and a kind of toothpaste.
Background technology
Toothpaste is the cleaning supplies commonly used in daily life, there is very long history.Originally toothpaste is essentially consisted in and tooth
Brush coordinates cleaning tooth, plays cleaning action.As the improvement of people's living standards, people increasingly focus on personal hygiene, toothpaste
Effect a variety of functions are gradually also developed into by simple cleaning.
The medicated toothpaste of in the market, can typically be summarized as following several：Preventing decayed tooth desensitization class toothpaste, activates blood circulation and disperses blood clots, improves generation
Thank class toothpaste and anti-inflammation class toothpaste.Wherein, preventing decayed tooth desensitization class toothpaste has certain effect to reducing carious tooth and desensitizing dental
Really, children and adolescents and the elderly are suitable selects.However, during preventing decayed tooth desensitization class toothpaste is typically generally toothpaste with fluoride, component
Added with sodium fluoride, stannous fluoride, strontium chloride etc., species is single.
The content of the invention
It is an object of the invention to provide a kind of biological activated glass ceramic material and preparation method thereof and a kind of toothpaste, sheet
Invent provide biological activated glass ceramic material can fast deposition class bone sample phosphorus lime, with promote dental surface remineralization
Effect；The toothpaste that the present invention is provided is main using biological activated glass ceramic material as functional mass, except tool during cleaning one's teeth
Have outside anti-dental sensitivity, also with dental surface remineralization is promoted, prevent dental decayed tooth and sensitivity of tooth.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The invention provides a kind of biological activated glass ceramic material, the component of following mass parts is included：
The invention provides a kind of preparation method of biological activated glass ceramic material described in above-mentioned technical proposal, comprising such as
Lower step：
(1) batch mixing is carried out according to the raw material composition of following mass parts, obtains mixtures of materials：
(2) mixtures of materials is sequentially melted and water quenching, one-level crushing then is carried out to water quenching product, obtained
One-level comminuting matter；
(3) controlled micro crystallization processing sequentially is carried out to the one-level comminuting matter and second patent flour is broken, obtain bioactivity glass pottery
Ceramic material.
It is preferred that, the temperature of the melting is 1300~1500 DEG C；
The time of the melting is 2~6h.
It is preferred that, the particle diameter of the one-level comminuting matter is 20~80 mesh.
It is preferred that, the controlled micro crystallization processing sequentially includes coring processing and isothermal holding；
The temperature of the coring processing is 600~700 DEG C；
The time of the coring processing is 1~3h；
The temperature of the isothermal holding is 750~900 DEG C；
The time of the isothermal holding is 2~3h.
It is preferred that, particle diameter≤100 μm of the biological activated glass ceramic material.
Present invention also offers a kind of toothpaste, containing biological activated glass ceramic material described in above-mentioned technical proposal or on
The biological activated glass ceramic material that preparation method described in stating technical scheme any one is obtained, includes following weight/mass percentage composition
Component：
It is preferred that, also comprising 0.1~0.5% preservative.
It is preferred that, the essence also comprising 0.1~0.5% sweetener and 0.6~3%.
It is preferred that, also comprising (0%, 0.5%] auxiliary agent and (0%, 0.5%] pigment.
The invention provides a kind of biological activated glass ceramic material and preparation method thereof and a kind of toothpaste.The present invention is provided
Biological activated glass ceramic material, include Na215~30 parts of O；15~45 parts of CaO；SiO225~55 parts；P2O55~25
Part；0.5~2.5 part of Zn；Sn0.5~3.0 part.The biological activated glass ceramic material that the present invention is provided being capable of fast deposition class
Bone sample phosphorus lime, during cleaning one's teeth in addition to anti-dental sensitivity, also with promote dental surface remineralization effect.
When the additive for toothpaste, it can effectively prevent dental decayed tooth and sensitivity of tooth.
Embodiment
The invention provides a kind of biological activated glass ceramic material, the component of following mass parts is included：
The biological activated glass ceramic material that the present invention is provided includes 15~30 parts of Na2O, it is preferably 18~28 parts, more excellent
Elect 20~25 parts as.
With 15~30 parts of Na2On the basis of O, the biological activated glass ceramic material that the present invention is provided includes 15~45 parts of CaO,
Preferably 20~40 parts, more preferably 25~35 parts.
With 15~30 parts of Na2On the basis of O, the biological activated glass ceramic material that the present invention is provided includes 25~55 parts of SiO2,
Preferably 30~50 parts, more preferably 35~45 parts.
With 15~30 parts of Na2On the basis of O, the biological activated glass ceramic material that the present invention is provided includes 5~25 parts of P2O5,
Preferably 10~20 parts, more preferably 13~16 parts.
With 15~30 parts of Na2On the basis of O, the biological activated glass ceramic material that the present invention is provided includes 0.5~2.5 part
Zn, more preferably preferably 1~2 part, 1.2~1.8 parts.Trace element zinc is to guiding treatment dental caries, periodontosis, fracture, extraction
Wound more etc. mouth disease have very big facilitation.
With 15~30 parts of Na2On the basis of O, the biological activated glass ceramic material that the present invention is provided includes 0.5~3.0 part
Sn, more preferably preferably 1~2.5 part, 1.5~2.0 parts.Tin element has good therapeutic action to treatment canker sore.
The invention provides a kind of preparation method of biological activated glass ceramic material described in above-mentioned technical proposal, comprising such as
Lower step：
(1) batch mixing is carried out according to the raw material composition of following mass parts, obtains mixtures of materials：
(2) mixtures of materials is sequentially melted and water quenching, one-level crushing then is carried out to water quenching product, obtained
One-level comminuting matter；
(3) controlled micro crystallization processing sequentially is carried out to the one-level comminuting matter and second patent flour is broken, obtain bioactivity glass pottery
Ceramic material.
Raw material of the raw material comprising following mass parts that the present invention prepares the biological activated glass ceramic material is constituted：
The present invention prepares the SiO that the raw material of the biological activated glass ceramic material includes 10~45 parts2, preferably 15~
40 parts, more preferably 20~30 parts.
With 10~45 parts of SiO2On the basis of, the present invention prepares the biological activated glass ceramic material raw material include 15~
60 parts of CaCO3, preferably 20~50 parts, more preferably 30~40 parts.
With 10~45 parts of SiO2On the basis of, the present invention prepares the biological activated glass ceramic material raw material include 25~
40 parts of Na2CO3, preferably 30~35 parts.
With 10~45 parts of SiO2On the basis of, the present invention prepares the biological activated glass ceramic material raw material include 3~
18 parts of P2O5, preferably 5~15 parts, more preferably 10~12 parts.
With 10~45 parts of SiO2On the basis of, the raw material that the present invention prepares the biological activated glass ceramic material includes 0.5
~2.5 parts of ZnO, more preferably preferably 1~2 part, 1.2~1.8 parts.
With 15~30 parts of Na2On the basis of O, the raw material that the present invention prepares the biological activated glass ceramic material includes 0.5
~3.0 parts of SnCl2, preferably 1~2.5 part, more preferably 1.2~1.5 parts.
The present invention is to the SiO2、CaCO3、Na2CO3、P2O5, ZnO and SnCl2Source without any particular/special requirement,
Can be specifically commercially available above-mentioned raw materials group using the above-mentioned raw materials component in source well known to those skilled in the art
Point.
The present invention carries out batch mixing according to above-mentioned raw materials composition, obtains mixtures of materials.Mode of the present invention to the batch mixing
There is no any particular/special requirement, can be well mixed by each raw material.
The uniform mixed mixture of the material is obtained, the mixtures of materials is sequentially melted and water quenching, so
One-level crushing is carried out to water quenching product afterwards, one-level comminuting matter is obtained.In the present invention, the temperature of the melting is preferably 1300
~1500 DEG C, most preferably more preferably 1350~1450 DEG C, 1400~1440 DEG C；The time of the melting is preferably 2~6h,
More preferably 3.0~5.5h, most preferably 4.0~5.0h.The present invention is preferably warming up to 1.0~20 DEG C/min firing rate
Described melts temperature, most preferably more preferably 5~15 DEG C/min, 10~13 DEG C/min.In the present invention, the melting is excellent
It is selected in crucible and carries out, the crucible is preferably silica crucible, clay pot or platinum crucible.
In the present invention, the specific purified water for the material after the melting directly to be poured into rapidly to 0 DEG C of the water quenching
Middle quenching.
After the water quenching terminates, the present invention is filtered to the water quenching product, and the solid matter being filtrated to get is carried out
Drying.In the present invention, the temperature of the drying is preferably 50~80 DEG C, more preferably 55~75 DEG C, most preferably 50~70
℃；The time of the drying is preferably 12~24h, more preferably 15~20h.
After the drying, the present invention carries out one-level crushing to the material after drying.In the present invention, the one-level is crushed excellent
Elect as and material to be comminuted is placed in suitable milling apparatus, in such as ball milling or impact grinding, will grind 2 hours, sieved, be divided into
Suitable particle diameter, obtains one-level comminuting matter.In the present invention, the particle diameter of the one-level comminuting matter is preferably 20~80 mesh,
More preferably 30~70 mesh, most preferably 40~60 mesh.The grinding mode that the present invention is crushed to the one-level does not have particular/special requirement,
The one-level comminuting matter for obtaining purpose particle diameter can be crushed.
Obtain after one-level comminuting matter, the present invention sequentially carries out controlled micro crystallization processing and second patent flour to the one-level comminuting matter
It is broken, obtain biological activated glass ceramic material.In the present invention, controlled micro crystallization processing it is preferred sequentially comprising coring processing and
Isothermal holding；The temperature of the coring processing is preferably 600~700 DEG C, more preferably 620~680 DEG C, most preferably 640~
660℃；The time of the coring processing is preferably 1~3h, more preferably 1.5~2.5h；The temperature of the isothermal holding is preferred
For 750~900 DEG C, more preferably 780~880 DEG C, most preferably 800~850 DEG C；The time of the isothermal holding is preferably 2
~3h, more preferably 2.5~2.8h.The present invention is preferably warming up to the temperature of the coring processing with 10~20 DEG C/min speed
Degree, most preferably more preferably 12~18 DEG C/min, 14~16 DEG C/min.The present invention is preferably by the body after controlled micro crystallization processing
System is cooled to after room temperature carries out the broken processing of second patent flour again.
In the present invention, the particle diameter of the second patent flour broken material namely the biological activated glass ceramic material be preferably≤
100 μm, more preferably≤80 μm, be most preferably≤60 μm.The present invention grinding mode broken to the second patent flour does not have any
Particular/special requirement, can crush the second patent flour broken material for obtaining purpose particle diameter.
Present invention also offers a kind of toothpaste, containing biological activated glass ceramic material described in above-mentioned technical proposal or on
The biological activated glass ceramic material that preparation method described in stating technical scheme any one is obtained, includes following weight/mass percentage composition
Component：
The toothpaste that the present invention is provided includes the biological activated glass ceramic material that weight percentage is 0.01~15%, excellent
Elect 2~12.0%, more preferably 3~10% as.In the present invention, the biological activated glass ceramic material is above-mentioned technology
The biology that preparation method described in biological activated glass ceramic material described in scheme or above-mentioned technical proposal any one is obtained is living
Property glass ceramic material, is no longer repeated herein.
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided contains including weight percent
Measure the rubbing agent for 12~55%, preferably 15~50%, more preferably 20~45%, most preferably 25~40%.In this hair
In bright, the rubbing agent is preferably the one or more in stone flour, silica, calcium monohydrogen phosphate and aluminium hydroxide, specially 1
Kind, 2 kinds, 3 kinds or 4 kinds.In the present invention, can arbitrary proportion mixing when the rubbing agent is 2~3 kinds of mentioned reagent；When
When the rubbing agent is 4 kinds of mentioned reagent, the mass ratio of the stone flour and silica, calcium monohydrogen phosphate, aluminium hydroxide is preferred
For (1~35):(1~30):(1~25):(1~20), more preferably (5~30):(5~25):(5~20):(5~15), most
Preferably (7~20):(7~15):(7~15):(7~12).The present invention is not particularly limited to the source of mentioned reagent, is used
The commercial goods that those skilled in the art routinely select.
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided contains including weight percent
Measure the NMF for 10~70%, preferably 20~60%, more preferably 30~50%.In the present invention, the NMF is excellent
Elect the one or more in glycerine, sorbierite, propane diols and polyethylene glycol, specially a kind, 2 kinds, 3 kinds or 4 kinds as.In this hair
, can arbitrary proportion mixing when the NMF is 2~3 kinds of mentioned reagent in bright；When the NMF is mentioned reagent
At 4 kinds, the glycerine and sorbierite, propane diols, the mass ratio of polyethylene glycol are preferably (1~45):(1~65):(1~40):
(1~20), more preferably (5~20):(10~60):(2~35):(1.5~10), be most preferably (7.5~10):(15~
40):(5~20):(2~5).The present invention is not particularly limited to the source of mentioned reagent, conventional using those skilled in the art
The commercial goods of selection.
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided contains including weight percent
Measure the binding agent for 0.5~2.5%, preferably 1~2%, more preferably 1.5%.In the present invention, the binding agent is preferably
Sodium carboxymethylcellulose, hydroxyethyl cellulose, HPG, xanthans, carragheen, carbomer, Magnesiumaluminumsilicate and pool
One or more in Luo Shamu.When the binding agent be said components in two kinds when, preferably sodium carboxymethylcellulose and
Xanthans；When the binding agent is three kinds in said components, preferably sodium carboxymethylcellulose, Magnesiumaluminumsilicate and OK a karaoke club
Glue.When the binding agent is sodium carboxymethylcellulose and xanthans, the mass ratio of the sodium carboxymethylcellulose and xanthans
Preferably (0.1~2.5):(0.1~2.5), more preferably (0.2~2.0):(0.2~2.0), be most preferably (0.3~1.5):
(0.3~1.5).When the binding agent is sodium carboxymethylcellulose, Magnesiumaluminumsilicate and carragheen, the sodium carboxymethylcellulose
Mass ratio with Magnesiumaluminumsilicate and carragheen is preferably (0.1~2.5):(0.1~2.0):(0.1~1.5), is most more preferably
(0.3~2.0):(0.3~1.5):(0.3~1.2), be most preferably (0.5~1.5):(0.5~1.2):(0.5~1.0).This
Invention is not particularly limited to the source of mentioned reagent, the commercial goods routinely selected using those skilled in the art.
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided contains including weight percent
Measure the foaming agent for 1~3%, preferably 1.5~2.5%, more preferably 2%.In the present invention, the foaming agent is preferably ten
The one or more of sodium dialkyl sulfate, sodium lauroyl sarcosine and Cocoamidopropyl betaine, specially a kind, 2 kinds or 3
Kind.In the present invention, when the foaming agent is two kinds in mentioned reagent, preferably lauryl sodium sulfate and lauroyl flesh
Propylhomoserin sodium；The mass ratio of the lauryl sodium sulfate and sodium lauroyl sarcosine is preferably (0.3~2.0):(0.3~2.0),
More preferably (0.5~1.5):(0.5~1.5), be most preferably (0.7~1.3)：(0.7~1.3).When the foaming agent is upper
When stating 3 kinds of reagent, the lauryl sodium sulfate and the mass ratio of sodium lauroyl sarcosine, Cocoamidopropyl betaine are preferred
For (0.1~1.5):(0.1~1.5):(0.1~1.5), more preferably (0.3~1.2):(0.3~1.2):(0.3~1.2),
Most preferably (0.5~1.0)：(0.5~1.0)：(0.5~1.0).The present invention is not particularly limited to the source of mentioned reagent,
The commercial goods routinely selected using those skilled in the art.
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided includes the water of surplus.
The present invention, without any particular/special requirement, can be specifically running water, deionized water or distilled water to the source of the water
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided preferably also includes weight
Percentage composition is 0.1~0.5% preservative, more preferably 0.2~0.4%, most preferably 0.3%.In the present invention, it is described
Preservative is preferably one or both of sodium benzoate and parabens.In the present invention, when the preservative is benzene first
When sour sodium and parabens, the mass ratio of the sodium benzoate and parabens is preferably (0.1~0.5):(0.1~
0.4), more preferably (0.15~0.4):(0.15~0.3).The present invention is not particularly limited to the source of mentioned reagent, is used
The commercial goods that those skilled in the art routinely select.
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided preferably also includes weight
Percentage composition is 0.1~0.5% sweetener, more preferably 0.2~0.4%, most preferably 0.3%.In the present invention, it is described
Sweetener is preferably the one or more in saccharin sodium, Aspartame, stevioside and Sucralose, specially a kind, 2 kinds, 3 kinds
Or 4 kinds.In the present invention, when the sweetener is two kinds in mentioned reagent, preferably saccharin sodium and stevioside；The sugar
The mass ratio of smart sodium and stevioside is preferably (0.05~0.4):(0.05~0.4), more preferably (0.1~0.3):(0.1~
0.3).When the sweetener is three kinds in mentioned reagent, preferably saccharin sodium, Sucralose and antierythrite；The sugar
Smart sodium and Sucralose, the mass ratio of antierythrite are preferably (0.05~0.3):(0.05~0.3):(0.05~0.3), it is more excellent
Elect as (0.1~0.2):(0.1~0.2):(0.1~0.2).The present invention is not particularly limited to the source of mentioned reagent, is used
The commercial goods that those skilled in the art routinely select.
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided preferably also includes weight
Percentage composition is 0.6~3% essence, more preferably 1~2%, most preferably 1.5%.Source of the present invention to the essence
It is not particularly limited, the commercial goods routinely selected using those skilled in the art, such as spearmint essence, Chinese ilex essence, water
Fruity essence etc..
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided preferably also includes weight
Percentage composition for (0%, 0.5%] auxiliary agent, more preferably [0.1%, 0.4%], be most preferably [0.2%, 0.3%].At this
In invention, the auxiliary agent is preferably one kind or many in tetrasodium pyrophosphate, sodium dihydrogen phosphate, sodium carbonate, sodium acid carbonate, sodium silicate
Kind, when the auxiliary agent is two kinds in mentioned reagent, preferably tetrasodium pyrophosphate and sodium dihydrogen phosphate；The tetrasodium pyrophosphate
Mass ratio with sodium dihydrogen phosphate is preferably (0.05~0.5):(0.05~0.5), more preferably (0.1~0.4):(0.1~
0.4), it is most preferably (0.15~0.3):(0.15~0.3).The present invention is not particularly limited to the source of mentioned reagent, is used
The commercial goods that those skilled in the art routinely select
On the basis of 0.01~15% biological activated glass ceramic material, the toothpaste that the present invention is provided preferably also includes weight
Percentage composition for (0%, 0.5%] pigment, more preferably [0.1%, 0.4%], be most preferably [0.2%, 0.3%].This hair
The bright source to the pigment is not particularly limited, the commercial goods routinely selected using those skilled in the art, such as titanium
White powder, light blue, quinoline yellow, lemon yellow etc..
In the present invention, when the toothpaste is simultaneously comprising bioactivity glass, rubbing agent, NMF, binding agent, foaming
When agent, sweetener, preservative, essence, auxiliary agent, the deionized water of pigment and surplus, the preparation method of the toothpaste is preferably included
Following steps：
A. NMF, sweetener, pigment, preservative and auxiliary agent are dissolved in the water, obtain aqueous phase solution；
B. under vacuum, the aqueous phase solution step a obtained and binding agent, foaming agent, bioactivity glass
Ceramic material and abrasive mixing, obtain reprocessing material；
C. under vacuum, the obtained reprocessing material of the step b are mixed with essence, obtains toothpaste.
NMF, sweetener, pigment, preservative and auxiliary agent are dissolved in the water by the present invention, obtain aqueous phase solution.The present invention
There is no special limitation to the method for the dissolving, using the technical scheme well known to those skilled in the art for preparing aqueous phase solution
.
Obtain after aqueous phase solution, the present invention is living by the aqueous phase solution and binding agent, foaming agent, biology under vacuum
Property glass ceramic material and abrasive mixing, obtain reprocessing material.In the present invention, the vacuum of the vacuum condition is preferred
For -0.05~-0.095MPa, more preferably -0.93MPa；The time of the mixing is preferably 50~60 minutes, more preferably 55
Minute.The present invention is mixed to the aqueous phase solution and binding agent, foaming agent, biological activated glass ceramic material and abrasive
Conjunction mode and order by merging do not have any particular/special requirement, can be well mixed.
Obtain after reprocessing material, the present invention mixes the reprocessing material with essence, obtains toothpaste.In the present invention, institute
The vacuum for stating vacuum condition is preferably -0.09~-0.095MPa, more preferably -0.093MPa；The time of the mixing is preferred
For 20~30 minutes, more preferably 25 minutes.
In the present invention, when the toothpaste does not include one kind or several in sweetener, preservative, essence, auxiliary agent and pigment
Kind when, the preparation method of the toothpaste is preferably carried out according to above-mentioned preparation method, will be related to the material that specifically omits and is omitted.
In the present invention, when the toothpaste is simultaneously comprising bioactivity glass, rubbing agent, NMF, binding agent, foaming
When agent, sweetener, preservative, essence, auxiliary agent, the deionized water of pigment and surplus, equipment of the present invention to preparing the toothpaste
It is not particularly limited, the equipment routinely selected using those skilled in the art, preferably vacuum Manufacturing medicine extract machine.
When preparing the toothpaste using vacuum Manufacturing medicine extract machine, specific flow is preferably：
1. NMF is sucked in vacuum Manufacturing medicine extract machine under vacuum conditions；
2. sweetener, pigment, preservative and auxiliary agent are dissolved in small powder pot with water, after stirring, in vacuum state
Stirred in lower suction vacuum Manufacturing medicine extract machine with NMF, obtain aqueous phase mixed solution；
3. binding agent, foaming agent and abrasive is poured into after being stirred in powder pot, vacuum is sucked under vacuum conditions
Manufacturing medicine extract machine neutralization procedure 2. in aqueous phase mixed solution stir, obtain reprocessing material；
4. it is stirred after the reprocessing material in sucking essence and step under vacuum conditions 3., produces toothpaste.
The present invention is not particularly limited to the application method and consumption of the toothpaste, conventional using those skilled in the art
Application method and consumption.
Biological activated glass ceramic material provided with reference to embodiment the present invention and preparation method thereof and toothpaste enter
Row detailed description, but they can not be interpreted as limiting the scope of the present invention.
Embodiment 1
Take SiO230g, CaCO335g, Na2CO332g, P2O52g, ZnO 1g, SnCl22.0g, after being well mixed, in platinum
1430 DEG C are warming up to 12 DEG C/min firing rate in crucible, melting 4.5h is well mixed, fused mass is then poured into 0 rapidly
It is quenched in DEG C purified water.Drying and processing 18h is carried out in 60 DEG C of temperature afterwards, processed material is placed in impact grinding, is ground 2 hours,
Sieved using 80 mesh sieves, obtain one-level comminuting matter.
Above-mentioned gained one-level comminuting matter is warming up to 650 DEG C with 15 DEG C/min firing rate and carries out coring processing 2h,
Then isothermal holding 2.5h is carried out, temperature is 830 DEG C.Then natural cooling is recovered to room temperature, is entered using above-mentioned impact grinding used
Row grinding 2 hours, isolates below 100 μm of particle diameter, produces bioactivity glass.
Embodiment 2
Calculated by toothpaste gross weight 100g, bioactivity glass 4g that wherein embodiment 1 is obtained, calcium monohydrogen phosphate 40g, titanium dioxide
Silicon 5g, sorbierite 20g, sodium carboxymethylcellulose 1g, lauryl sodium sulfate 2.0g, saccharin sodium 0.2g, sodium benzoate 0.1g, perfume (or spice)
Smart 0.6g and surplus deionized water；
Preparation method：
The vacuum of vacuum Manufacturing medicine extract machine is set to -0.093MPa, first NMF, sweetener, preservative, auxiliary agent is dissolved
Aqueous phase mixed solution is obtained in deionized water, in suction vacuum Manufacturing medicine extract machine, then by binding agent, foaming agent, rubbing agent and biology
Activity glass solution mixed with water mixes 50min in vacuum Manufacturing medicine extract machine, obtains reprocessing material, finally by essence and reprocessing
Material mixes 25min in vacuum Manufacturing medicine extract machine, obtains toothpaste.
Embodiment 3
The gained toothpaste of embodiment 2 is contrasted with the commercially available ordinary toothpaste not containing fluoride, has tooth decay 180
Patient be divided into three groups, test group is 60, the toothpaste containing bioactivity glass, and positive controls is are proved effective fluorine-containing
60, toothpaste, negative control group is 60, the toothpaste without bioactive materials and fluoride, and all experiment toothpaste wrap to be unified
Dress.All subjects use the ordinary toothbrush of the same model of same manufacturer production.All subjects at least use toothpaste daily
Brush teeth twice, toothpaste is covered with whole bristle, it is continuous to use 6 weeks.
The toothpaste experiment effect contrast table of table 1
| Group | Number of cases | Effectively | It is invalid |
| Experimental group | 60 | 48 | 12 |
| Positive control | 60 | 50 | 10 |
| Negative control | 60 | 19 | 41 |
By experimental group, positive controls and negative control group test result indicates that, it is of the present invention include bioactivity
The toothpaste of glass has remarkable result to dental caries.
As seen from the above embodiment, the invention provides a kind of biological activated glass ceramic material and preparation method thereof and one
Plant toothpaste.The biological activated glass ceramic material that the present invention is provided, includes Na215~30 parts of O；15~45 parts of CaO；SiO225
~55 parts；P2O55~25 parts；0.5~2.5 part of Zn；Sn0.5~3.0 part.The biological activated glass ceramic material that the present invention is provided
Can fast deposition class bone sample phosphorus lime, during cleaning one's teeth in addition to anti-dental sensitivity, also with promote tooth table
The effect of face remineralization.When the additive for toothpaste, it can effectively prevent dental decayed tooth and sensitivity of tooth.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of biological activated glass ceramic material, includes the component of following mass parts：
2. the preparation method of biological activated glass ceramic material described in claim 1, is comprised the following steps：
(1) batch mixing is carried out according to the raw material composition of following mass parts, obtains mixtures of materials：
(2) mixtures of materials is sequentially melted and water quenching, one-level crushing then is carried out to water quenching product, one-level is obtained
Comminuting matter；
(3) controlled micro crystallization processing sequentially is carried out to the one-level comminuting matter and second patent flour is broken, obtain biological active glass ceramic material
Material.
3. preparation method according to claim 2, it is characterised in that the temperature of the melting is 1300~1500 DEG C；
The time of the melting is 2~6h.
4. preparation method according to claim 2, it is characterised in that the particle diameter of the one-level comminuting matter is 20~80
Mesh.
5. preparation method according to claim 2, it is characterised in that the controlled micro crystallization processing sequentially comprising coring processing and
Isothermal holding；
The temperature of the coring processing is 600~700 DEG C；
The time of the coring processing is 1~3h；
The temperature of the isothermal holding is 750~900 DEG C；
The time of the isothermal holding is 2~3h.
6. preparation method according to claim 2, it is characterised in that the particle diameter of the biological activated glass ceramic material≤
100μm。
7. a kind of toothpaste, contains biological activated glass ceramic material described in claim 1 or claim 2~6 any one
The biological activated glass ceramic material that the preparation method is obtained, it is characterised in that include the component of following weight/mass percentage composition：
8. toothpaste according to claim 7, it is characterised in that also comprising 0.1~0.5% preservative.
9. toothpaste according to claim 7, it is characterised in that also comprising 0.1~0.5% sweetener and 0.6~3%
Essence.
10. the toothpaste according to claim 7~9 any one, it is characterised in that also comprising (0%, 0.5%] auxiliary agent
(0%, 0.5%] pigment.
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