CN101756878A - Medical dental cream for oral health care of children and preparation method thereof - Google Patents
Medical dental cream for oral health care of children and preparation method thereof Download PDFInfo
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- 230000036541 health Effects 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000006071 cream Substances 0.000 title claims abstract description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000000843 powder Substances 0.000 claims abstract description 19
- 210000002969 egg yolk Anatomy 0.000 claims abstract description 17
- 108060003951 Immunoglobulin Proteins 0.000 claims abstract description 16
- 102000018358 immunoglobulin Human genes 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 13
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 12
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 12
- 229940034610 toothpaste Drugs 0.000 claims description 29
- 239000000606 toothpaste Substances 0.000 claims description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 27
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 16
- 244000293323 Cosmos caudatus Species 0.000 claims description 16
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000003292 glue Substances 0.000 claims description 9
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 8
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- -1 Polyethylene Polymers 0.000 claims description 8
- 239000004698 Polyethylene Substances 0.000 claims description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 8
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 8
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
- 229920000573 polyethylene Polymers 0.000 claims description 8
- 229940085605 saccharin sodium Drugs 0.000 claims description 8
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 8
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 8
- 239000004408 titanium dioxide Substances 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 3
- 238000001514 detection method Methods 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 19
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 9
- 210000000214 mouth Anatomy 0.000 abstract description 8
- 208000025865 Ulcer Diseases 0.000 abstract description 4
- 239000002994 raw material Substances 0.000 abstract description 4
- 210000002784 stomach Anatomy 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- 231100000397 ulcer Toxicity 0.000 abstract description 4
- 206010061218 Inflammation Diseases 0.000 abstract description 3
- 238000004140 cleaning Methods 0.000 abstract description 3
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 3
- 208000027418 Wounds and injury Diseases 0.000 abstract description 2
- 210000003298 dental enamel Anatomy 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract description 2
- 210000000952 spleen Anatomy 0.000 abstract description 2
- 210000001835 viscera Anatomy 0.000 abstract description 2
- 230000035876 healing Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 description 16
- 208000002399 aphthous stomatitis Diseases 0.000 description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- 208000025157 Oral disease Diseases 0.000 description 6
- 208000030194 mouth disease Diseases 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 5
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 241000879903 Pteria Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000002308 calcification Effects 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- 201000001245 periodontitis Diseases 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- FXALIOUHXMVTMJ-UHFFFAOYSA-N CCCCCCCCCCCC([Na])=O Chemical compound CCCCCCCCCCCC([Na])=O FXALIOUHXMVTMJ-UHFFFAOYSA-N 0.000 description 1
- 241000382825 Cristaria plicata Species 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 241000382840 Hyriopsis cumingii Species 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000007886 mutagenicity Effects 0.000 description 1
- 231100000299 mutagenicity Toxicity 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 208000004480 periapical periodontitis Diseases 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 229940048098 sodium sarcosinate Drugs 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention relates to medical dental cream for the oral health care of children and a preparation method thereof. In the formula of the medical dental cream, IGY (egg immunoglobulin of yolk) with specificity aiming at decayed teeth and pearl powder are used as main raw materials, wherein the added pearl powder can be in direct contact with a wound surface to eliminate the inflammation of an ulcer surface, and meanwhile, the pearl powder can be absorbed by internal organs and has the functions of clearing away heat and toxic materials, clearing the stomach, lowering fire and removing accumulated heat of the spleen and the stomach, thus oral taking and external use are carried out for considering both root causes and symptoms to accelerate the healing rate of the ulcer surface of the oral cavity. Moreover, by matching with the moderate cleaning effect of silicon dioxide used as a light abradant in the dental cream, the medical dental cream can effectively protect the tooth enamel, the gingivae and teeth which are not completely calcified, and the medical dental cream is particularly suitable for the delicate oral environment of children and has good effect on preventing and curing the decayed teeth and oral ulcers. Raw material componnets of the medical dental cream have no harmful chemical substances, and even if the medical dental cream is swallowed by mistake, the medical dental cream cannot generate any side effect. The invention has reasonable formula, simple process and quite obvious use effect.
Description
Technical field
The present invention relates to a kind of toothpaste and preparation method thereof, particularly a kind of medicated toothpaste that is used for oral health care of children and preparation method thereof.
Background technology
At present, oral diseases such as dental caries, periodontitis, oral ulcer are one of the most general frequently-occurring diseases of each age group crowd.Wherein dental caries in child and teenager prevalence at 70%-90%.Various toothpaste of Chu Xianing in the market, though prescription is different, but generally all contain fluorine, triclosan, harmful materials such as dodecanoyl sodium sarcosinate, in use should avoid swallowing as far as possible, but the 15%-20% that studies show that each consumption when the adult brushes teeth will be swallowed by mistake, and the child is more, about 40% of each consumption will be swallowed by mistake, and life-time service makes noxious substance be accumulated in the human body, serious harm health, in addition, mostly contain abrasivuss such as calcium carbonate, calcium phosphate in adult's ointment, adult's toothpaste abrasive hardness height, frictional force is big, easy damaged child's tooth.
Dental caries is a bacterial disease, so it can secondary pulpitis and periapical periodontitis, even can cause alveolar bone and inflammation of jaws.Oral ulcer be a kind of be the oral mucosa limitation ulcer infringement of characteristics with outbreak periodically repeatedly, can spontaneous recovery, can betide any position of oral mucosa, see that with lip, cheek, tongue severe patient can involve pharyngeal mucosa more.
Therefore, provide a kind of application convenience, obvious results to be used for medicated toothpaste of oral health care of children and preparation method thereof, promptly become one of these those skilled in the art problem anxious to be addressed.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of technology is simple, obvious results is used for medicated toothpaste of oral health care of children and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object:
A kind of medicated toothpaste that is used for oral health care of children is characterized in that this medicated toothpaste is prepared from by following composition:
The composition parts by weight
Sorbitol 35-40;
Sodium lauryl sulphate 1-2;
Water 6-8;
Saccharin sodium 0.1-0.5;
Methyl hydroxybenzoate 0.05-0.2;
Tetrasodium pyrophosphate 0.1-1;
Glycerol 15-25;
Polyethylene Glycol-12 3-8;
Cellulose gum 0.1-1;
Silicon dioxide 20-30;
Essence 0.5-1.5;
Titanium dioxide 0.1-1;
Margarita powder 0.5-2;
Yolk immunoglobulin 0.001-0.003.
A kind of preparation method that is used for the medicated toothpaste of oral health care of children, concrete implementation step is as follows:
Step (1) glue:
Water, sorbitol, sodium lauryl sulphate, the methyl hydroxybenzoate of above-mentioned weight portion are dropped in the reactor, and the dissolving material left standstill 20 minutes;
Saccharin sodium, the tetrasodium pyrophosphate of above-mentioned weight portion are dissolved in 80 ℃ of hot water, drop in the reactor;
In premixed device, drop into glycerol, the Polyethylene Glycol-12 of above-mentioned weight portion, drop into cellulose gum again; This mixture and aforementioned material were evenly stirred 15 minutes in reactor, and it is standby to make the glue discharging;
Step (2) system cream:
After the glue that step (1) is made added Manufacturing medicine extract machine fully, uncapping added the Yolk immunoglobulin of above-mentioned weight portion, and added Margarita powder, titanium dioxide, the silicon dioxide of above-mentioned weight portion through essence hopper mouth;
It is even to continue to keep being stirred to mixing of materials fast, and control vacuum progressively rises to 0.08Mpa, adds essence by essence hopper mouth again, closes manual vacuum valve after adding; Regularly sample detection, fill.
This medicated toothpaste of preventing and treating oral diseases such as dental caries not only can cleaning teeth, and can the effectively preventing oral disease, and is safe in utilization, without any side effects.
The present invention chooses following raw material (being commercially available) and illustrates as main functional component and pharmacology thereof:
Yolk immunoglobulin IGY (Immunoglobulin of yolk) is the commercially available prod; Promptly be the γ-livitin in the yolk, because there is certain difference in aspects such as its proteinic physicochemical properties, immunological properties with mammal IgG, therefore the antibody that obtains in birds yolk at the field of immunology handle calls Yolk immunoglobulin.
The pathogenic bacterium that cause oral disease have a variety of, and what wherein cause dental caries mainly is that Streptococcus mutans is main several antibacterials and lactobacterium acidophilus.The anti-tooth decay IgY immunoglobulin is the target antibody that is prepared from the The main pathogenic fungi-Streptococcus mutans that causes dental caries specially, but the antigen of its Direct Recognition Streptococcus mutans, combination by specificity and targeting, make antibacterial forfeiture sticking and growth and breeding at dental surface, have very strong oral cavity bacterium and kill and scavenging action, therefore effectively caries prevention takes place.
Relevant research checking dental caries immune globulin IgY is having obvious effect aspect the prevention decayed tooth, and IgY can effectively stop the development of dental caries.Aspect safety, IgY belongs to nontoxic level class material, and no mutagenicity is the safety preparation.
Margarita powder (Pearl powder) is with hydriopsis cumingii Hyriopsis cumingii (Lea), cristaria plicata Cristaria plicata (Leach), pteria martensii Pteria martensii Margaritas that shell-fish produces such as (Dunker), grind the powder that forms, be white in color, the special fishy smell of Margarita is arranged.
Add Margarita powder among the present invention, not only can directly contact, eliminate the inflammation of ulcer surface with wound surface, Margarita powder is gone into internal organs simultaneously also heat-clearing and toxic substances removing, clearing stomach pathogenic fire reducing, the function of removal retention of heat in the spleen and stomach, the oral administration and externally giving consideration to both the incidental and fundamental is accelerated the speed that oral ulcer surface heals, and effect is remarkable.
The lightweight abrasivus silicon dioxide that adds among the present invention is fit to the tender and lovely oral environment of child, effectively protects the not tooth of complete calcification of oral mucosa Buddhist monk; Compare heavy abrasivuss such as calcium carbonate, calcium pyrophosphate and have mildness, be difficult for tooth is caused physically impaired characteristics.
The invention has the beneficial effects as follows: the invention provides a kind of formulation of tooth-paste of preventing and treating oral disease that aims at designed for children; compare with product in the market; prescription is with " specificity is at the IGY Yolk immunoglobulin of dental caries " and " Margarita powder " core as product; and the cleaning action of lightweight abrasivus gentleness in the cooperation lotion of toothpaste; effectively take care of one's teeth enamel and gingiva and the complete tooth of calcification not as yet have good effect to preventing and treating dental caries and oral ulcer.No any chemical harmful substance in its constituent is not if can produce any side effect after being swallowed by mistake.
The present invention is directed to the weak point of current toothpaste, especially at dental caries, oral ulcer and the brand-new type safe drugs toothpaste that research design comes out.Be characterized in: main component is to control agent IGY at the immunity of pathogen, and without any side effects; Specificity is at pathogen, and prevention effect is remarkable, and safety is good, the frictional force gentleness, damage tooth is not harmless even do not gargle in the back of brushing teeth yet, and is the good toothpaste of a kind of security performance, easy to use, especially be fit to the child, be beneficial to oral cavity health, promote childhood development to grow up.The present invention fills a prescription rationally, and technology is simple, the result of use highly significant.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows for feature:
Every part of embodiment 1:(is by 1k g)
A kind of medicated toothpaste that is used for oral health care of children comprises following composition: sorbitol 35kg, sodium lauryl sulphate 1.5kg, water 6kg, saccharin sodium 0.2kg, methyl hydroxybenzoate 0.1kg, tetrasodium pyrophosphate 0.5kg, glycerol 25kg, Polyethylene Glycol-12 6kg, cellulose gum 0.5kg, silicon dioxide 23kg, essence 0.7kg, titanium dioxide 0.5kg, Margarita powder 1kg, Yolk immunoglobulin 0.001kg.
Concrete preparation process is as follows:
Step (1) glue (following Water-solubility Material is mixed into translucent sticking shape liquid state):
Water, sorbitol, sodium lauryl sulphate, the methyl hydroxybenzoate of above-mentioned weight portion are dropped in the reactor, and the dissolving material left standstill 20 minutes;
Saccharin sodium, the tetrasodium pyrophosphate of above-mentioned weight portion are dissolved in 80 ℃ of hot water,, drop in the reactor to dissolving fully;
In premixed device, drop into glycerol, the Polyethylene Glycol-12 of above-mentioned weight portion, drop into cellulose gum again; This mixture and aforementioned material were evenly stirred 15 minutes in reactor, and it is standby to make the glue discharging;
Step (2) system cream:
Open cooling water, energized is opened air compressor as the operational power source;
After the glue that step (1) is made added Manufacturing medicine extract machine fully, uncapping added the Yolk immunoglobulin (IGY) of above-mentioned weight portion, and added Margarita powder, titanium dioxide (pigment) and the silicon dioxide of above-mentioned weight portion through essence hopper mouth;
It is even to continue to keep being stirred to mixing of materials fast, and control vacuum progressively rises to 0.08Mpa, adds essence by essence hopper mouth again, closes manual vacuum valve after adding; Regularly sample detection, fill.
Exemplify primary raw material source and specification requirement:
Margarita powder: purchase in precious biological product company limited, the fineness≤75 μ m revealed of eyot.
Yolk immunoglobulin (IGY): purchase in Bai'ao Biotechnology Co., Ltd., Zhuhai City (model: L-Igy), immunoglobulin purity 〉=75%.
Glycerol:＞98.5%, purchase in Zhaoqing long queue bio tech ltd.
Silicon dioxide: the H type, content 〉=96% is purchased in Zhaoqing gold Sanjiang Chemical Co., Ltd.
Every part of embodiment 2:(is by 1k g)
A kind of medicated toothpaste that is used for oral health care of children comprises following composition: sorbitol 40kg, sodium lauryl sulphate 1kg, water 7kg, saccharin sodium 0.1kg, methyl hydroxybenzoate 0.05kg, tetrasodium pyrophosphate 0.2kg, glycerol 19kg, Polyethylene Glycol-12 5kg, cellulose gum 0.15kg, silicon dioxide 24.5kg, essence 1kg, titanium dioxide 0.5kg, Margarita powder 1.5kg, Yolk immunoglobulin 0.003kg.
Preparation method and other are with embodiment 1.
Every part of embodiment 3:(is by 1k g)
A kind of medicated toothpaste that is used for oral health care of children comprises following composition: sorbitol 38kg, sodium lauryl sulphate 2kg, water 6.5kg, saccharin sodium 0.4kg, methyl hydroxybenzoate 0.15kg, tetrasodium pyrophosphate 0.7kg, glycerol 16kg, Polyethylene Glycol-128kg, cellulose gum 0.8kg, silicon dioxide 28kg, essence 0.5kg, titanium dioxide 0.7kg, Margarita powder 0.6kg, Yolk immunoglobulin 0.002kg.
Preparation method and other are with embodiment 1.
The effect explanation:
The present invention has added Yolk immunoglobulin (IGY) and Margarita powder and other additive, wetting agent by a certain percentage, prevent and treat dental caries for people daily use, particularly child, oral diseases such as oral ulcer have good action, can effectively suppress oral cavity pathogen grows, prevent dental caries, oral ulcer and have safety, the nonhazardous effect, mistake is swallowed without any side effects.
Toothpaste result of use of the present invention illustrates:
1, choice criteria: select case history by the conventional diagnostic criteria of assert of medical treatment;
2, user: 4-12 one full year of life child, man: 42 examples, woman: 30 examples;
3, using method: brush teeth 2 time with this toothpaste every day, and each once adhered to using 2 months sooner or later;
4, curative effect determinate standard: a effect is remarkable, and symptom disappears substantially; B is effective, and symptom is most of to take a turn for the better; C is not obvious, does not reach effective standard or sx.The results are shown in Table 1.
Table 1 toothpaste effect of the present invention is used statistical table
| Number | The a effect is remarkable | B is effective | C is not obvious | Effective percentage (%) | |
| Dental caries | ??24 | ?21 | ?2 | ?1 | ??95.8％ |
| Periodontitis | ??24 | ?17 | ?5 | ?2 | ??91.7％ |
| Oral ulcer | ??24 | ?18 | ?3 | ?3 | ??87.5％ |
Frictional force is contrasted:
In order to verify the mildness of abrasive silicas, choose the silicon dioxide that the present invention adopts, calcium carbonate, calcium pyrophosphate, 4 kinds of common abrasivuss of calcium hydrogen phosphate are used " crossing the grit analyzer " and are carried out the frictional force contrast by increasing the number of times observation microscope slide cut number that rubs also all with in the same parts by weight adding toothpaste matrix.Experimental result such as table 2.
Table 2 friction number of times and cut synopsis
By analyzing as seen, when the friction number of times was 100 times, cut did not all appear in 4 kinds of toothpaste, along with the increase of friction number of times, cut in various degree all occurred; But toothpaste cut number of the present invention is minimum, and this shows that the present invention adopts abrasive silicas etc. to have the gentleest minimum frictional force, the most difficult tooth is caused physical damnification, and effect is good.
Above-mentioned with reference to embodiment to the detailed description that this medicated toothpaste that is used for oral health care of children and preparation method thereof carries out, be illustrative rather than determinate; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (2)
1. medicated toothpaste that is used for oral health care of children is characterized in that this medicated toothpaste is prepared from by following composition:
The composition parts by weight
Sorbitol 35-40;
Sodium lauryl sulphate 1-2;
Water 6-8;
Saccharin sodium 0.1-0.5;
Methyl hydroxybenzoate 0.05-0.2;
Tetrasodium pyrophosphate 0.1-1;
Glycerol 15-25;
Polyethylene Glycol-12 3-8;
Cellulose gum 0.1-1;
Silicon dioxide 20-30;
Essence 0.5-1.5;
Titanium dioxide 0.1-1;
Margarita powder 0.5-2;
Yolk immunoglobulin 0.001-0.003.
2. preparation method that is used for the medicated toothpaste of oral health care of children according to claim 1 is characterized in that concrete implementation step is as follows:
Step (1) glue:
Water, sorbitol, sodium lauryl sulphate, the methyl hydroxybenzoate of above-mentioned weight portion are dropped in the reactor, and the dissolving material left standstill 20 minutes;
Saccharin sodium, the tetrasodium pyrophosphate of above-mentioned weight portion are dissolved in 80 ℃ of hot water, drop in the reactor;
In premixed device, drop into glycerol, the Polyethylene Glycol-12 of above-mentioned weight portion, drop into cellulose gum again; This mixture and aforementioned material were evenly stirred 15 minutes in reactor, and it is standby to make the glue discharging;
Step (2) system cream:
After the glue that step (1) is made added Manufacturing medicine extract machine fully, uncapping added the Yolk immunoglobulin of above-mentioned weight portion, and added Margarita powder, titanium dioxide, the silicon dioxide of above-mentioned weight portion through essence hopper mouth;
It is even to continue to keep being stirred to mixing of materials, and control vacuum progressively rises to 0.08Mpa, adds essence by essence hopper mouth again, closes manual vacuum valve after adding; Regularly sample detection, fill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010135298 CN101756878A (en) | 2010-03-30 | 2010-03-30 | Medical dental cream for oral health care of children and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010135298 CN101756878A (en) | 2010-03-30 | 2010-03-30 | Medical dental cream for oral health care of children and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641216A (en) * | 2012-04-20 | 2012-08-22 | 湖北楚冠生物药业有限公司 | Tooth-strengthening and odontogeny-preventing element and preparation method thereof |
| CN105534866A (en) * | 2016-01-25 | 2016-05-04 | 陈威宇 | Preparation method of multiple-effect toothpaste capable of removing stains and conducting maintenance |
| CN106137817A (en) * | 2015-04-14 | 2016-11-23 | 拉萨班公湖中药材有限责任公司 | Toothpaste |
| CN108601720A (en) * | 2015-10-26 | 2018-09-28 | 高露洁-棕榄公司 | oral care product and method |
| CN108852949A (en) * | 2018-09-20 | 2018-11-23 | 天津博真集团有限公司 | A kind of preparation method of anion toothpaste |
| CN109528578A (en) * | 2017-12-26 | 2019-03-29 | 李文婷 | A kind of whitening hemostasis oral cavity nursing agent |
| CN110478267A (en) * | 2019-09-27 | 2019-11-22 | 中合泰克(南京)生物科技有限公司 | A kind of efficient anti-caries children's toothpaste and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357310A (en) * | 2000-12-05 | 2002-07-10 | 侯敏 | Soluble pearl powder compound |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1357310A (en) * | 2000-12-05 | 2002-07-10 | 侯敏 | Soluble pearl powder compound |
Non-Patent Citations (1)
| Title |
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| 《牙体牙髓牙周病学杂志》 20081231 王祝玲等 抗龋IgY牙膏对乳牙防龋效果的临床研究 334-337 1-2 第18卷, 第6期 2 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641216A (en) * | 2012-04-20 | 2012-08-22 | 湖北楚冠生物药业有限公司 | Tooth-strengthening and odontogeny-preventing element and preparation method thereof |
| CN106137817A (en) * | 2015-04-14 | 2016-11-23 | 拉萨班公湖中药材有限责任公司 | Toothpaste |
| CN108601720A (en) * | 2015-10-26 | 2018-09-28 | 高露洁-棕榄公司 | oral care product and method |
| CN105534866A (en) * | 2016-01-25 | 2016-05-04 | 陈威宇 | Preparation method of multiple-effect toothpaste capable of removing stains and conducting maintenance |
| CN109528578A (en) * | 2017-12-26 | 2019-03-29 | 李文婷 | A kind of whitening hemostasis oral cavity nursing agent |
| CN108852949A (en) * | 2018-09-20 | 2018-11-23 | 天津博真集团有限公司 | A kind of preparation method of anion toothpaste |
| CN110478267A (en) * | 2019-09-27 | 2019-11-22 | 中合泰克(南京)生物科技有限公司 | A kind of efficient anti-caries children's toothpaste and preparation method thereof |
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Application publication date: 20100630 |