CN108969458A - Permanent tooth tooth-caring toothpaste and preparation method thereof - Google Patents
Permanent tooth tooth-caring toothpaste and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention discloses permanent tooth tooth-caring toothpastes, including the following raw material in parts by weight: 15-40 parts of calcined oyster shell shell Ultramicro-powder, 8-10 parts of Radix Morindae Officinalis extract, 5-10 parts of vitamin C, 1-20 parts of lauryl sodium sulfate, 5-20 parts of glycerol, 0.5-2.5 parts of sodium carboxymethylcellulose, 0.5-3 parts of xanthan gum, 20-30 parts of sorbierite, 0.2-1.5 parts of sodium lauroyl sarcosine, 0.5-3 parts of menthol, 0.05-5.5 parts of colorant, 1.0-1.5 parts of preservative, 1.0-1.5 parts of essence, 0.2-0.5 parts of sweetener and 12-26 parts of deionized water.The invention also discloses a kind of preparation methods of permanent tooth tooth-caring toothpaste.Toothpaste of the invention is arranged in pairs or groups using calcined oyster shell shell Ultramicro-powder as rubbing agent with Radix Morindae Officinalis extract and vitamin C, has effects that firm gum, anti-inflammatory antibacterial, improvement oral inflammation, solid protecting teeth.
Description
Technical field
The present invention relates to daily chemical product fields.It is more particularly related to a kind of permanent tooth tooth-caring toothpaste and its
Preparation method.
Background technique
Daily necessities of the toothpaste as cleaning tooth, most important effect is exactly to clean and take care of one's teeth and oral cavity, tooth
Easily the problem of hair, essentially consists in the problems such as gingival sensitivity, bleeding gums, saprodontia, tooth mobility, various focusing depths represented swelling and pain etc., everything
To have its source in tooth itself not firm enough, just as secondary body its own hypoimmunity, be easy the same reason of illness, because
This just should first carry out the work of solid protecting teeth to prophylaxis of teeth disease.
Currently, toothpaste plays the rubbing agent ingredient of cleaning action, mainly with calcium carbonate, calcium phosphate dibasic dihydrate, titanium dioxide
Based on silicon, although these types of rubbing agent can play the role of friction cleaning tooth, but but have to facing and periodontium
Different degrees of abrasion, rubbing agent obtain the particle of different thicknesses and hardness through different technique, frictional behaviour is also different, has
Study differentiated friction agent to dentine carry out radioactivity (RDA) test the result shows that, the RDA of silica is 90-137, two
The RDA of hypophosphite monohydrate hydrogen calcium is 100-110, and the RDA of natural whiting is 152-186, and the RDA of precipitated calcium carbonate is 90-100,
RDA is smaller, and frictional property is smaller, smaller to periodontal damage.
Chitosan can effectively inhibit the proliferation of a variety of harmful bacterias in conjunction with bacterial cell membrane in oyster shell, improve mouth
Chamber flora environment, the multi-pore structure of oyster shell can effectively adsorb peculiar smell and residual impurity in oral cavity, play fresh breath
Effect, and oyster shell is rich in the calcium carbonate of biosynthesis, has the characteristics of excellent mechanical, hardness height, good toughness, energy gram
Take the weaker problem of the scale removal ability of the simple calcium carbonate rubbing agent of existing market.There is patent of invention to disclose a kind of shuck beauty white
Toothpaste prepares toothpaste by rubbing agent of oyster shell powder, makes full use of waste, is carried out by way of high-temperature calcination to oyster shell
Pre-treatment obtains the main component suitable for toothpaste abrasives, however, the toothpaste of different calcining manners processing oyster shell preparations
Frictional behaviour it is different, it is also different to the friction effect and the degree of wear of dentine, although calcining oyster shell can replace it is common
Rubbing agent, but it is still bigger to the abrasion of dentine and periodontal oral cavity stimulation degree, still has promotion on solid protecting teeth
Space.
Morinda officinalis is the liana of Rubiaceae Morinda, is grown on the ground such as Fujian, Guangdong and Guangxi more.Modern medicine
Research shows that Morinda officinalis has the function of inhibiting inflammation, strengthening the muscles and bones.And vitamin C is essential as body metabolism activity
Compound has the effects that antibacterial, antiviral, anti-oxidant.It had not yet to see with oyster shell powder and Radix Morindae Officinalis extract and dimension
Raw element C is main component, has effects that the significant natural tooth paste product for consolidating protecting teeth, therefore before having a vast market application
Scape.
Summary of the invention
The present invention has a purpose to be to provide a kind of permanent tooth tooth-caring toothpaste, with calcined oyster shell shell Ultramicro-powder for main rubbing agent,
It arranges in pairs or groups with Radix Morindae Officinalis extract and vitamin C, there is firm gum, anti-inflammatory antibacterial, analgesia detumescence, improvement canker sore and oral cavity
The effect of inflammation, the effect of playing solid protecting teeth.
It is a still further object of the present invention to provide a kind of preparation method of permanent tooth tooth-caring toothpaste, this method is simply easy to industry
Metaplasia produces toothpaste, and the toothpaste frictional behaviour prepared is excellent and minimum to periodontal damage, can preferably protect the health of one's teeth.
A further object of the invention is to further increase the cleaning capacity of toothpaste, and drop by adding friction aid
Low toothpaste enhances oral immunisation ability to the polishing machine of oral cavity tissue, consolidates the ability that tooth resists the disease.
In order to realize these purposes and other advantages according to the present invention, a kind of permanent tooth tooth-caring toothpaste is provided, including with
The following raw material of parts by weight meter: 15-40 parts of calcined oyster shell shell Ultramicro-powder, 8-10 parts of Radix Morindae Officinalis extract, 5-10 parts of vitamin C, ten
1-20 parts of sodium dialkyl sulfate, 5-20 parts of glycerol, 0.5-2.5 parts of sodium carboxymethylcellulose, 0.5-3 parts of xanthan gum, sorbierite 20-
30 parts, 0.2-1.5 parts of sodium lauroyl sarcosine, 0.5-3 parts of menthol, 0.05-5.5 parts of colorant, 1.0-1.5 parts of preservative,
1.0-1.5 parts of essence, 0.2-0.5 parts of sweetener and 12-26 parts of deionized water.
Preferably, the permanent tooth tooth-caring toothpaste, the sweetener are one or both of xylitol, stevioside
Mixture, the preservative are sodium benzoate or potassium sorbate, and the colorant is titanium dioxide.
Preferably, the permanent tooth tooth-caring toothpaste further includes 8-10 parts of Angelica Dahurica extract.
Preferably, the permanent tooth tooth-caring toothpaste, the calcined oyster shell shell Ultramicro-powder the preparation method is as follows: by oyster shell
It removes coarse crushing after remaining meat, attachment and cuticula and obtains the oyster shell coarse powder that diameter is 1-3mm, then by oyster shell coarse powder
It send to high temperature stove heating calcining and activating 0.5-2h, cooling after taking-up, then being crushed to partial size through planetary ball mill pulverizer is 1-30 μ
M to obtain the final product.
Preferably, the permanent tooth tooth-caring toothpaste, in the preparation method of the calcined oyster shell shell Ultramicro-powder, oyster shell calcining
The specific method is as follows for activation:
A1, by oyster shell coarse powder prior to 250 DEG C at calcine 2h, pulverize and sieve 200 mesh, obtain calcined oyster shell shell powder；
A2, it takes pelelith to be placed at 400 DEG C to calcine 3h, pulverizes and sieves 200 mesh, obtain volcano stone flour, it is spare；
A3, by calcined oyster shell shell powder, volcano stone flour, far-infared ceramic powder and hydromel according to weight ratio be 100:1:2:800
Mixing, stir evenly, prior to 80 DEG C at heating stirring 30min, be again heated to boiling, continue cooking 15-20min, obtain mixing slurry
Material, mixed slurry is immediately placed at -25 DEG C and freezes 8h, obtains freezing slurry, and the mass fraction of the hydromel is 20%；
A4, freezing slurry is placed in again at 400 DEG C and calcines 1h, it is spare.
Preferably, the permanent tooth tooth-caring toothpaste, the Radix Morindae Officinalis extract the preparation method is as follows:
B1, Morinda officinalis is cleaned, is dried, coarse crushing crosses 20 meshes and obtains Morinda officinalis coarse powder, by Morinda officinalis coarse powder and magnetized water
After for 1:6 mixing, it is placed in colloid mill grinding 30min, Morinda officinalis slurry is obtained, is placed at 40 DEG C, ultrasonic power is
It is ultrasonically treated 1h under conditions of 200w, filters 100 mesh, obtains the first filtrate and the first filter residue；
It B2, by the first filter residue with magnetized water is by weight that 1:5 is mixed, heating is boiled, and continues to heat 25min, filtering 100
Mesh obtains the second filtrate and the second filter residue, and the second filter residue is immediately placed at -25 DEG C and freezes 5h；
B3, the second filter residue after freezing is thawed, and 4 times of magnetized water of its weight and 1/4 Mi of its weight is added
Monkey peach enzyme liquid is uniformly mixed, and then the closed processes 10h at 35 DEG C filters 100 mesh, obtain third filtrate and third filter residue, institute
It states Kiwi berry enzyme liquid and Kiwi berry slurries is made by Kiwi berry pulp, then by Kiwi berry slurries, honey, probiotics and deionized water
It is after 10:3:1:40 is mixed, to be sealed by fermentation 7-10 days and obtain according to weight ratio, the probiotics is that Bifidobacterium and saccharomycete are pressed
It is 1:1 composition according to weight ratio；
B4, third filter residue is used volume fraction extract 2 times for 90% alcohol reflux, 5-10 times of volume is added every time
Alcohol reflux extracts 2h, and filters, and merges the filtrate of refluxing extraction twice, and recycles the ethyl alcohol in filtrate, obtains the 4th filtrate；
B5, the first filtrate, the second filtrate, third filtrate and the 4th filtrate are uniformly mixed to obtain mixed filtrate, are concentrated into mixed
The 1/3 of filtrate original volume is closed, it is then spray-dried to obtain the Radix Morindae Officinalis extract.
Based on the above-mentioned technical proposal, the invention also discloses a kind of preparation methods of permanent tooth tooth-caring toothpaste, including following step
It is rapid:
1) glycerol of above-mentioned parts by weight, sodium carboxymethylcellulose, xanthan gum, sorbierite and deionized water are sequentially added into system
Stirring 40-50min for the first time is carried out in cream machine, obtains the first mixture；
2) be added into the first mixture the Radix Morindae Officinalis extracts of above-mentioned parts by weight, vitamin C, menthol, sweetener and
Preservative carries out second of stirring 20-30min under vacuum environment, obtains the second mixture；
3) the calcined oyster shell shell Ultramicro-powder of above-mentioned parts by weight is added in the second mixture, carries out third time stirring 1-1.5h
Afterwards, the dodecyl sodium sulfate and sodium lauroyl sarcosine for adding above-mentioned parts by weight stir for the 4th time under vacuum environment
2-3h is mixed, third mixture is obtained；
4) essence and colorant of above-mentioned parts by weight, the 5th stirring 0.5-1h, then at normal are added into third mixture
Closed under temperature, storage and aging 2-3h is up to toothpaste；
Wherein, vacuum degree is 0.15-2.06MPa under vacuum environment.
Preferably, the preparation method of the permanent tooth tooth-caring toothpaste, the speed of stirring is 400r/min for the first time；Second
The speed of secondary stirring is 500r/min；The speed of third time stirring is 1000r/min；The speed of 4th stirring is 300r/
min；The speed of 5th stirring is 500r/min.
Preferably, the preparation method of the permanent tooth tooth-caring toothpaste, step 3) be added into the second mixture forge it is male
When oyster shell Ultramicro-powder, while friction aid is added, content is the 15% of calcined oyster shell shell Ultramicro-powder weight, the friction auxiliary
Agent the preparation method is as follows:
C1, the acidic mixed solution that pH is 3-4 is prepared, is wherein 15%- containing mass concentration in acidic mixed solution
20% macromolecule mixture, the macromolecule mixture are made of avenabeta glucosan and gelatin with mass ratio for 1:4；
C2, the acidic mixed solution is handled by electrostatic spinning, high polymer nanometer fiber is obtained, in 45 DEG C of hot air dryings
It is dry to be lower than 15% to moisture, it crushed 100 mesh, obtain nanofiber powder；
C3, it takes luffa to be cut into small pieces, is placed in boiling water and boils 15min, take out fritter luffa and be immediately placed at -25 DEG C
Freeze 5h, taking-up be placed on heated-air drying 10h at 60 DEG C, then crush sieve with 100 mesh sieve to obtain Loofah powder, by Loofah powder with go
Ionized water is defibrination after 1:3 mixing by weight, obtains luffa slurry, then the β-Isosorbide-5-Nitrae-inscribe wood for being 15% with mass fraction gathers
Carbohydrase solution is 5:1 mixing by weight, at 30-35 DEG C, digests 2h, then be placed in heated-air drying 8h at 80 DEG C, crushed 100
Mesh obtains loofah fiber powder；
C4, nanofiber powder is uniformly mixed with loofah fiber powder according to mass ratio for 1:4, obtains the friction auxiliary
Agent.
Preferably, Morinda offcinalis How is added to the first mixture in step 2) in the preparation method of the permanent tooth tooth-caring toothpaste
When its extract, while being added 8-10 parts of Angelica Dahurica extract.
The present invention is include at least the following beneficial effects:
1) present invention is raw material using calcined oyster shell shell, and specific calcining and activating processing is carried out to it, improves its intrinsic carbonic acid
The frictional behaviour of calcium, and reduce natural oyster shell powder to the abrasiveness of periodontal；Due to containing constituent of chitosan and spy in oyster shell
Different pore structure can inhibit a variety of harmful bacterias to breed more comprehensively in conjunction with vitamin C and Radix Morindae Officinalis extract, improve mouth
Chamber flora environment protects oral cavity, prevents oral inflammation, consolidates gum and dental health, removes oral peculiar smell, keeps implication clear
Newly；
2) present invention is with the volcano stone flour of calcination processing and far-infared ceramic powder, calcined oyster shell shell powder and hydromel is heated boils
Freezing, calcination processing after boiling, further improving calcium carbonate in calcined oyster shell shell powder reduces toothpaste pair to dentin abrasion performance
The stimulation of oral tissue cell and tooth itself, and increase Stomatocyte vigor, enhancing histocyte metabolism promotes cell
Autoimmune function and repair ability consolidate the health in tooth gum oral cavity；
3) Radix Morindae Officinalis extract of the invention is concentrated and dried by the filtrate of 4 step by step arithmetic and is made, and sufficiently promotes Morinda offcinalis How
Cell tissue broken wall in it, beneficiating ingredient are released, by water-soluble composition, enzymatic hydrolysis ingredient, under magnetized water and ethyl alcohol effect
Sufficiently to extract, the effect of improving anti-inflammatory Morinda officinalis, permanent tooth；
4) present invention promotes the frictional behaviour of oyster shell, and further decrease it to oral cavity by addition friction aid
The polishing machine of tissue is wherein used in toothpaste in friction aid with nanofiber powder made of avenabeta glucosan and gelatin
Other than outstanding adsorption capacity, also there is excellent flexibility, and the spy that loofah fiber powder not only has frictional property excellent
Point has effects that clearing and activating the channels and collaterals, removing toxicity for detumescence, can prevent and treat mouth disease；
5) present invention is added to Angelica Dahurica extract in toothpaste, has antibacterial, antiallergy, analgesia and other effects, quick to tooth
Sense damage has certain healing effect, while can promote the antibacterial ability of toothpaste, to further protect the health of one's teeth；
6) method that the present invention prepares toothpaste, simple process make tooth by mixing speed, mixing time and vacuum environment
Various ingredients in cream adequately mix, and glue melts, and obtain that tissue is fine and smooth, cleannes are good, and minimum toothpaste is worn to oral cavity, is assisted
Improve the protective effect to tooth.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Specific embodiment
The present invention is described in further detail combined with specific embodiments below, to enable those skilled in the art's reference say
Bright book text can be implemented accordingly.
It should be noted that experimental method described in following embodiments is unless otherwise specified conventional method, institute
Reagent and material are stated, unless otherwise specified, is commercially obtained.
Embodiment 1:
A kind of permanent tooth tooth-caring toothpaste, including the following raw material in parts by weight: 15 parts of calcined oyster shell shell Ultramicro-powder, Morinda officinalis mention
Take 8 parts of object, 5 parts of vitamin C, 1 part of lauryl sodium sulfate, 5 parts of glycerol, 0.5 part of sodium carboxymethylcellulose, xanthan gum 0.5
Part, 20 parts of sorbierite, 0.2 part of sodium lauroyl sarcosine, 0.5 part of menthol, 0.05 part of colorant, 1.0 parts of preservative, essence
1.0 parts, 0.2 part of sweetener and 12 parts of deionized water.
Wherein, the sweetener is xylitol, and the preservative is sodium benzoate, and the colorant is titanium dioxide.
The Radix Morindae Officinalis extract is the commercially available extract obtained using alcohol extracting method.
Wherein, the calcined oyster shell shell Ultramicro-powder the preparation method is as follows: oyster shell is removed remaining meat, attachment and angle
Coarse crushing obtains the oyster shell coarse powder that diameter is 1-3mm after matter layer, then oyster shell coarse powder is sent and is forged to high temperature stove heating to 250 DEG C
Burn activation 2h, it is cooling after taking-up, then through planetary ball mill pulverizer be crushed to partial size be 1-30 μm to obtain the final product.
Based on the above-mentioned technical proposal, the invention also discloses a kind of preparation methods of permanent tooth tooth-caring toothpaste, including following step
It is rapid:
1) glycerol of above-mentioned parts by weight, sodium carboxymethylcellulose, xanthan gum, sorbierite and deionized water are sequentially added into system
Stirring 40min for the first time is carried out in cream machine, obtains the first mixture；
2) be added into the first mixture the Radix Morindae Officinalis extracts of above-mentioned parts by weight, vitamin C, menthol, sweetener and
Preservative carries out second of stirring 20min under vacuum environment, obtains the second mixture；
3) the calcined oyster shell shell Ultramicro-powder of above-mentioned parts by weight is added in the second mixture, after carrying out third time stirring 1h,
The dodecyl sodium sulfate and sodium lauroyl sarcosine for adding above-mentioned parts by weight carry out the 4th stirring under vacuum environment
2h obtains third mixture；
4) essence and colorant of above-mentioned parts by weight, the 5th stirring 0.5h, then at room temperature are added into third mixture
Under it is closed, storage and aging 2h is up to toothpaste；
Wherein, vacuum degree is 0.15MPa under vacuum environment；
Wherein, the speed of stirring is 400r/min for the first time；The speed of second of stirring is 500r/min；Third time stirs
Speed be 1000r/min；The speed of 4th stirring is 300r/min；The speed of 5th stirring is 500r/min.
Embodiment 2:
A kind of permanent tooth tooth-caring toothpaste, including the following raw material in parts by weight: 40 parts of calcined oyster shell shell Ultramicro-powder, Morinda officinalis mention
Take 10 parts of object, 10 parts of vitamin C, 20 parts of lauryl sodium sulfate, 20 parts of glycerol, 2.5 parts of sodium carboxymethylcellulose, xanthan gum 3
Part, 30 parts of sorbierite, 1.5 parts of sodium lauroyl sarcosine, 3 parts of menthol, 5.5 parts of colorant, 1.5 parts of preservative, essence 1.5
Part, 0.5 part of sweetener and 26 parts of deionized water.
Wherein, the sweetener is stevioside, and the preservative is potassium sorbate, and the colorant is gardenia blue.
The Radix Morindae Officinalis extract is the commercially available extract obtained using alcohol extracting method.
Wherein, the calcined oyster shell shell Ultramicro-powder the preparation method is as follows: oyster shell is removed remaining meat, attachment and angle
Coarse crushing obtains the oyster shell coarse powder that diameter is 1-3mm after matter layer, then oyster shell coarse powder is sent and is forged to high temperature stove heating to 600 DEG C
Burn activation 0.5h, it is cooling after taking-up, then through planetary ball mill pulverizer be crushed to partial size be 1-30 μm to obtain the final product.
Based on the above-mentioned technical proposal, the invention also discloses a kind of preparation methods of permanent tooth tooth-caring toothpaste, including following step
It is rapid:
1) glycerol of above-mentioned parts by weight, sodium carboxymethylcellulose, xanthan gum, sorbierite and deionized water are sequentially added into system
Stirring 50min for the first time is carried out in cream machine, obtains the first mixture；
2) be added into the first mixture the Radix Morindae Officinalis extracts of above-mentioned parts by weight, vitamin C, menthol, sweetener and
Preservative carries out second of stirring 30min under vacuum environment, obtains the second mixture；
3) the calcined oyster shell shell Ultramicro-powder of above-mentioned parts by weight is added in the second mixture, carries out third time stirring 1.5h
Afterwards, the dodecyl sodium sulfate and sodium lauroyl sarcosine for adding above-mentioned parts by weight stir for the 4th time under vacuum environment
3h is mixed, third mixture is obtained；
4) essence and colorant of above-mentioned parts by weight, the 5th stirring 1h, under room temperature are added into third mixture
Closed, storage and aging 3h is up to toothpaste；
Wherein, vacuum degree is 2.06MPa under vacuum environment；
Wherein, the speed of stirring is 400r/min for the first time；The speed of second of stirring is 500r/min；Third time stirs
Speed be 1000r/min；The speed of 4th stirring is 300r/min；The speed of 5th stirring is 500r/min.
Embodiment 3:
A kind of permanent tooth tooth-caring toothpaste, including the following raw material in parts by weight: 28 parts of calcined oyster shell shell Ultramicro-powder, Morinda officinalis mention
Take 9 parts of object, 8 parts of vitamin C, 10 parts of lauryl sodium sulfate, 12 parts of glycerol, 1.5 parts of sodium carboxymethylcellulose, xanthan gum 1.8
Part, 25 parts of sorbierite, 0.8 part of sodium lauroyl sarcosine, 1.8 parts of menthol, 2.5 parts of colorant, 1.2 parts of preservative, essence 1.2
Part, 0.3 part of sweetener and 19 parts of deionized water.
Wherein, the sweetener is xylitol, and the preservative is sodium benzoate, and the colorant is titanium dioxide,
Also the food based colorant of other colors, use as needed can be used in different tooth paste products.
The Radix Morindae Officinalis extract is the commercially available extract obtained using alcohol extracting method.
Wherein, the calcined oyster shell shell Ultramicro-powder the preparation method is as follows: oyster shell is removed remaining meat, attachment and angle
Coarse crushing obtains the oyster shell coarse powder that diameter is 1-3mm after matter layer, then oyster shell coarse powder is sent and is forged to high temperature stove heating to 400 DEG C
Burn activation 1.5h, it is cooling after taking-up, then through planetary ball mill pulverizer be crushed to partial size be 1-30 μm to obtain the final product.
Based on the above-mentioned technical proposal, the invention also discloses a kind of preparation methods of permanent tooth tooth-caring toothpaste, including following step
It is rapid:
1) glycerol of above-mentioned parts by weight, sodium carboxymethylcellulose, xanthan gum, sorbierite and deionized water are sequentially added into system
Stirring 45min for the first time is carried out in cream machine, obtains the first mixture；
2) be added into the first mixture the Radix Morindae Officinalis extracts of above-mentioned parts by weight, vitamin C, menthol, sweetener and
Preservative carries out second of stirring 25min under vacuum environment, obtains the second mixture；
3) the calcined oyster shell shell Ultramicro-powder of above-mentioned parts by weight is added in the second mixture, carries out third time stirring 1.25h
Afterwards, the dodecyl sodium sulfate and sodium lauroyl sarcosine for adding above-mentioned parts by weight stir for the 4th time under vacuum environment
2.5h is mixed, third mixture is obtained；
4) essence and colorant of above-mentioned parts by weight, the 5th stirring 0.5h, then at room temperature are added into third mixture
Under it is closed, storage and aging 3h is up to toothpaste；
Wherein, vacuum degree is 1.02MPa under vacuum environment；
Wherein, the speed of stirring is 400r/min for the first time；The speed of second of stirring is 500r/min；Third time stirs
Speed be 1000r/min；The speed of 4th stirring is 300r/min；The speed of 5th stirring is 500r/min.
Embodiment 4:
On the basis of embodiment 3, the permanent tooth tooth-caring toothpaste further includes 8-10 parts of Angelica Dahurica extract, in step 2)
When the middle addition Radix Morindae Officinalis extract to the first mixture, while Angelica Dahurica extract is added.
Embodiment 5:
On the basis of embodiment 3, the permanent tooth tooth-caring toothpaste, in the preparation method of the calcined oyster shell shell Ultramicro-powder,
The specific method is as follows for oyster shell calcining and activating:
A1, by oyster shell coarse powder prior to 250 DEG C at calcine 2h, pulverize and sieve 200 mesh, obtain calcined oyster shell shell powder；
A2, it takes pelelith to be placed at 400 DEG C to calcine 3h, pulverizes and sieves 200 mesh, obtain volcano stone flour, it is spare；
A3, by calcined oyster shell shell powder, volcano stone flour, far-infared ceramic powder and hydromel according to weight ratio be 100:1:2:800
Mixing, stir evenly, prior to 80 DEG C at heating stirring 30min, be again heated to boiling, continue cooking 15-20min, obtain mixing slurry
Material, mixed slurry is immediately placed at -25 DEG C and freezes 8h, obtains freezing slurry, and the mass fraction of the hydromel is 20%；
A4, freezing slurry is placed in again at 400 DEG C and calcines 1h, it is spare.
Remaining is the same as embodiment 3.
Embodiment 6:
On the basis of embodiment 3, the permanent tooth tooth-caring toothpaste, the Radix Morindae Officinalis extract the preparation method is as follows:
B1, Morinda officinalis is cleaned, is dried, coarse crushing crosses 20 meshes and obtains Morinda officinalis coarse powder, by Morinda officinalis coarse powder and magnetized water
After for 1:6 mixing, it is placed in colloid mill grinding 30min, Morinda officinalis slurry is obtained, is placed at 40 DEG C, ultrasonic power is
It is ultrasonically treated 1h under conditions of 200w, filters 100 mesh, obtains the first filtrate and the first filter residue；
It B2, by the first filter residue with magnetized water is by weight that 1:5 is mixed, heating is boiled, and continues to heat 25min, filtering 100
Mesh obtains the second filtrate and the second filter residue, and the second filter residue is immediately placed at -25 DEG C and freezes 5h；
B3, the second filter residue after freezing is thawed, and 4 times of magnetized water of its weight and 1/4 Mi of its weight is added
Monkey peach enzyme liquid is uniformly mixed, and then the closed processes 10h at 35 DEG C filters 100 mesh, obtain third filtrate and third filter residue, institute
It states Kiwi berry enzyme liquid and Kiwi berry slurries is made by Kiwi berry pulp, then by Kiwi berry slurries, honey, probiotics and deionized water
It is after 10:3:1:40 is mixed, to be sealed by fermentation 7-10 days and obtain according to weight ratio, the probiotics is that Bifidobacterium and saccharomycete are pressed
It is 1:1 composition according to weight ratio；
B4, third filter residue is used volume fraction extract 2 times for 90% alcohol reflux, 5-10 times of volume is added every time
Alcohol reflux extracts 2h, and filters, and merges the filtrate of refluxing extraction twice, and recycles the ethyl alcohol in filtrate, obtains the 4th filtrate；
B5, the first filtrate, the second filtrate, third filtrate and the 4th filtrate are uniformly mixed to obtain mixed filtrate, are concentrated into mixed
The 1/3 of filtrate original volume is closed, it is then spray-dried to obtain the Radix Morindae Officinalis extract.
Embodiment 7:
On the basis of embodiment 3, the preparation method of the permanent tooth tooth-caring toothpaste, in step 3) into the second mixture
When calcined oyster shell shell Ultramicro-powder is added, while friction aid is added, content is the 15% of calcined oyster shell shell Ultramicro-powder weight, described
Friction aid the preparation method is as follows:
C1, the acidic mixed solution that pH is 3-4 is prepared, is wherein 15%- containing mass concentration in acidic mixed solution
20% macromolecule mixture, the macromolecule mixture are made of avenabeta glucosan and gelatin with mass ratio for 1:4；
C2, the acidic mixed solution is handled by electrostatic spinning, high polymer nanometer fiber is obtained, in 45 DEG C of hot air dryings
It is dry to be lower than 15% to moisture, it crushed 100 mesh, obtain nanofiber powder；
Wherein, the technological parameter of the electrostatic spinning are as follows: charging gear temperature is 35-45 DEG C, delivery rate 50-
80ul/min, charging gear and collection device spacing are 10-15cm, and environment temperature is 20-30 DEG C, flow rate of ambient air 0-
5.5m3/ h, spinning voltage 10-20kV；
C3, it takes luffa to be cut into small pieces, is placed in boiling water and boils 15min, take out fritter luffa and be immediately placed at -25 DEG C
Freeze 5h, taking-up be placed on heated-air drying 10h at 60 DEG C, then crush sieve with 100 mesh sieve to obtain Loofah powder, by Loofah powder with go
Ionized water is defibrination after 1:3 mixing by weight, obtains luffa slurry, then the β-Isosorbide-5-Nitrae-inscribe wood for being 15% with mass fraction gathers
Carbohydrase solution is 5:1 mixing by weight, at 30-35 DEG C, digests 2h, then be placed in heated-air drying 8h at 80 DEG C, crushed 100
Mesh obtains loofah fiber powder；
C4, nanofiber powder is uniformly mixed with loofah fiber powder according to mass ratio for 1:4, obtains the friction auxiliary
Agent.
Embodiment 8:
On the basis of embodiment 5, the permanent tooth tooth-caring toothpaste, the Radix Morindae Officinalis extract the preparation method is as follows:
B1, Morinda officinalis is cleaned, is dried, coarse crushing crosses 20 meshes and obtains Morinda officinalis coarse powder, by Morinda officinalis coarse powder and magnetized water
After for 1:6 mixing, it is placed in colloid mill grinding 30min, Morinda officinalis slurry is obtained, is placed at 40 DEG C, ultrasonic power is
It is ultrasonically treated 1h under conditions of 200w, filters 100 mesh, obtains the first filtrate and the first filter residue；
It B2, by the first filter residue with magnetized water is by weight that 1:5 is mixed, heating is boiled, and continues to heat 25min, filtering 100
Mesh obtains the second filtrate and the second filter residue, and the second filter residue is immediately placed at -25 DEG C and freezes 5h；
B3, the second filter residue after freezing is thawed, and 4 times of magnetized water of its weight and 1/4 Mi of its weight is added
Monkey peach enzyme liquid is uniformly mixed, and then the closed processes 10h at 35 DEG C filters 100 mesh, obtain third filtrate and third filter residue, institute
It states Kiwi berry enzyme liquid and Kiwi berry slurries is made by Kiwi berry pulp, then by Kiwi berry slurries, honey, probiotics and deionized water
It is after 10:3:1:40 is mixed, to be sealed by fermentation 7-10 days and obtain according to weight ratio, the probiotics is that Bifidobacterium and saccharomycete are pressed
It is 1:1 composition according to weight ratio；
B4, third filter residue is used volume fraction extract 2 times for 90% alcohol reflux, 5-10 times of volume is added every time
Alcohol reflux extracts 2h, and filters, and merges the filtrate of refluxing extraction twice, and recycles the ethyl alcohol in filtrate, obtains the 4th filtrate；
B5, the first filtrate, the second filtrate, third filtrate and the 4th filtrate are uniformly mixed to obtain mixed filtrate, are concentrated into mixed
The 1/3 of filtrate original volume is closed, it is then spray-dried to obtain the Radix Morindae Officinalis extract.
Calcined oyster shell shell Ultramicro-powder is added into the second mixture in step 3) for the preparation method of the permanent tooth tooth-caring toothpaste
When, while friction aid is added, content is the 15% of calcined oyster shell shell Ultramicro-powder weight, the preparation side of the friction aid
Method is as follows:
C1, the acidic mixed solution that pH is 3-4 is prepared, is wherein 15%- containing mass concentration in acidic mixed solution
20% macromolecule mixture, the macromolecule mixture are made of avenabeta glucosan and gelatin with mass ratio for 1:4；
C2, the acidic mixed solution is handled by electrostatic spinning, high polymer nanometer fiber is obtained, in 45 DEG C of hot air dryings
It is dry to be lower than 15% to moisture, it crushed 100 mesh, obtain nanofiber powder；
Wherein, the technological parameter of the electrostatic spinning are as follows: charging gear temperature is 35-45 DEG C, delivery rate 50-
80ul/min, charging gear and collection device spacing are 10-15cm, and environment temperature is 20-30 DEG C, flow rate of ambient air 0-
5.5m3/ h, spinning voltage 10-20kV；
C3, it takes luffa to be cut into small pieces, is placed in boiling water and boils 15min, take out fritter luffa and be immediately placed at -25 DEG C
Freeze 5h, taking-up be placed on heated-air drying 10h at 60 DEG C, then crush sieve with 100 mesh sieve to obtain Loofah powder, by Loofah powder with go
Ionized water is defibrination after 1:3 mixing by weight, obtains luffa slurry, then the β-Isosorbide-5-Nitrae-inscribe wood for being 15% with mass fraction gathers
Carbohydrase solution is 5:1 mixing by weight, at 30-35 DEG C, digests 2h, then be placed in heated-air drying 8h at 80 DEG C, crushed 100
Mesh obtains loofah fiber powder；
C4, nanofiber powder is uniformly mixed with loofah fiber powder according to mass ratio for 1:4, obtains the friction auxiliary
Agent.
Comparative example 1:
On the basis of embodiment 3, a kind of whitening toothpaste, wherein the method for oyster shell activation is as follows: by natural air drying
Oyster shell is heated to 50-100 DEG C of heat preservation 0.5h in high temperature furnace, and crushing sieves with 100 mesh sieve, then send to high temperature stove heating to 100-150
DEG C, 1h is kept the temperature, then crushed 300-500 mesh, then high temperature furnace is sent to be heated to 250 DEG C, heat preservation 1h comes out of the stove, spare, nothing after cooling
It must be pulverized and sieved using planetary ball mill.The method that remaining prepares toothpaste is same as Example 3.
In order to illustrate the beneficial effect of toothpaste of the invention, the present inventor has carried out following tests:
Test one, measurement toothpaste influence odontotripsis
Have the toothpaste (using calcium carbonate as rubbing agent) of shield tooth effect for reference using certain commercially available brand, with comparative example 1
Toothpaste is comparison, and the radiation of dentin abrasion is carried out to the toothpaste of embodiment 3-8 preparation, referring to toothpaste and the toothpaste of comparative example 1
Property active testing, specific method is: using human teeth root (dentine) as test object, test object being embedded in one
The V-8 for simulating male's toothbrush dynamics intersects on tooth brushing device, sets toothbrushing force as 150g, starts toothpaste slurry agitating device, often
Group embodiment carries out parallel test test to 5 teeth simultaneously, stops after setting 2min, and toothpaste slurries are dry, measurement32P's
Exit dose analyzes toothpaste frictional behaviour by exit dose, and test result is shown in Table 1.Friction valve RDA is bigger, and frictional behaviour is stronger, right
The wear resistance of dentine is also bigger, and the RDA value of all toothpaste should all be lower than 250 (as defined in U.S. Food and Drug Administration
Upper limit value).
The different toothpaste of table 1. influence the abrasion of dentine
As it can be seen from table 1 although commercially available tooth-caring toothpaste and comparative example 1 and the toothpaste of embodiment 3-8 preparation are all
Using calcium carbonate as the main component of rubbing agent, but its frictional behaviour is that difference is quite big, wherein the friction valve referring to toothpaste is maximum,
Calcium carbonate therein is natural magnesium calcium component, although comparative example 1 and the toothpaste abrasives of embodiment 3-8 all derive from oyster
Shell, but due to the processing method of oyster shell difference, cause its frictional behaviour different, and embodiment 3, embodiment 4, embodiment 6 are rubbed
It wipes damaging close with comparative example 1.Calcined oyster shell shell Ultramicro-powder in embodiment 5 is due to pelelith of having arranged in pairs or groups, far-infared ceramic powder
And honey, in addition to oyster shell powder after boiling freezing processing, further reduced toothpaste to the abrasiveness of dentine.Embodiment
7 are added to friction aid on the basis of embodiment 3, while promoting toothpaste friction cleaning efficacy, improve toothpaste and rub
The flexibility of liniment reduces the abrasion to dentine, improves safety of the toothpaste to tooth friction level, is more advantageous to guarantor
Protect tooth.
Test two, animal experiment
Healthy SPF grades of KM mouse 90,25 ± 5g of weight, daily cycle 12h/12h, 22 ± 1 DEG C of room temperature are taken, diet is certainly
By adapting to environment 3 days.If blank group, model group, Dentifrice treatment group and positive drug aspirin for treatment group, wherein therapeutic component
6 groups are not set according to toothpaste prepared by embodiment 3, embodiment 4, embodiment 5, embodiment 6, embodiment 7, embodiment 8, amounts to 9
Group, every group of 10 mouse.
Wherein, the mouse of blank group is without any processing；
The mouse of model group establishes the inflammatory model of mouse toes enlargement with carrageenan induction, to suffer from inflammation mouse；
The mouse of Dentifrice treatment group is adopted while establishing the inflammatory model of mouse toes enlargement with carrageenan induction
The toothpaste difference film affected part prepared with each embodiment 3 days, daily each 3 times；
The mouse of positive drug aspirin for treatment group, in the inflammatory model for establishing mouse toes enlargement with carrageenan induction
While, affected part is continuously smeared 3 days using the aspirin medical fluid of 0.1mg/ml, each 3 times daily；
Daily affected part situation of change is recorded, using the toes volume in toes capacity measurer measurement mouse third day, is taken fully
Toe tissue samples measure osteoblast number using Immunohistochemical Method, the results are shown in Table 2.
Influence of the 2. permanent tooth tooth-caring toothpaste of table to mouse toes volume and osteoblast
Note: for model group compared with blank group, * indicates P < 0.05, has a significant impact, and * * indicates P < 0.01, has extremely significant
It influences；Treatment group compared with model group,#It indicates P < 0.05, has a significant impact,##It indicates P < 0.01, there is extremely significant influence.
It is learnt by table 2, after permanent tooth tooth-caring toothpaste smears treatment, the mouse toes enlargement of carrageenan induction is obtained
It is obviously improved, equally matched with the curative effect of positive drug aspirin, the osteoblast expression of mouse increased significantly, hence it is evident that better than sun
Property medicine aspirin for treatment group, it can be seen that, toothpaste of the invention has the function of solid protecting teeth.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and embodiment shown and described herein.
Claims (10)
1. permanent tooth tooth-caring toothpaste, which is characterized in that including the following raw material in parts by weight: 15-40 parts of calcined oyster shell shell Ultramicro-powder,
8-10 parts of Radix Morindae Officinalis extract, 5-10 parts of vitamin C, 1-20 parts of lauryl sodium sulfate, 5-20 parts of glycerol, carboxymethyl cellulose
Plain sodium 0.5-2.5 parts, 0.5-3 parts of xanthan gum, 20-30 parts of sorbierite, 0.2-1.5 parts of sodium lauroyl sarcosine, menthol 0.5-3
Part, 0.05-5.5 parts of colorant, 1.0-1.5 parts of preservative, 1.0-1.5 parts of essence, 0.2-0.5 parts of sweetener and deionized water
12-26 parts.
2. permanent tooth tooth-caring toothpaste as described in claim 1, which is characterized in that the sweetener is xylitol, in stevioside
One or two kinds of mixtures, the preservative are sodium benzoate or potassium sorbate, and the colorant is titanium dioxide.
3. permanent tooth tooth-caring toothpaste as described in claim 1, which is characterized in that further include 8-10 parts of Angelica Dahurica extract.
4. permanent tooth tooth-caring toothpaste as described in claim 1, which is characterized in that the preparation method of the calcined oyster shell shell Ultramicro-powder is such as
Under: coarse crushing after the remaining meat of oyster shell removal, attachment and cuticula is obtained into the oyster shell coarse powder that diameter is 1-3mm, then
Oyster shell coarse powder is sent to high temperature stove heating calcining and activating 0.5-2h, cooling after taking-up, then is crushed through planetary ball mill pulverizer
To partial size be 1-30 μm to obtain the final product.
5. permanent tooth tooth-caring toothpaste as claimed in claim 4, which is characterized in that the preparation method of the calcined oyster shell shell Ultramicro-powder
In, the specific method is as follows for oyster shell calcining and activating:
A1, by oyster shell coarse powder prior to 250 DEG C at calcine 2h, pulverize and sieve 200 mesh, obtain calcined oyster shell shell powder；
A2, it takes pelelith to be placed at 400 DEG C to calcine 3h, pulverizes and sieves 200 mesh, obtain volcano stone flour, it is spare；
A3, calcined oyster shell shell powder, volcano stone flour, far-infared ceramic powder and hydromel are mixed according to weight ratio for 100:1:2:800,
Stir evenly, prior to 80 DEG C at heating stirring 30min, be again heated to boiling, continue cook 15-20min, obtain mixed slurry, will
Mixed slurry is immediately placed at -25 DEG C and freezes 8h, obtains freezing slurry, and the mass fraction of the hydromel is 20%；
A4, freezing slurry is placed in again at 400 DEG C and calcines 1h, it is spare.
6. permanent tooth tooth-caring toothpaste as described in claim 1, which is characterized in that the preparation method of the Radix Morindae Officinalis extract is such as
Under:
B1, Morinda officinalis is cleaned, is dried, coarse crushing crosses 20 meshes and obtains Morinda officinalis coarse powder, by Morinda officinalis coarse powder and magnetized water by weight
Amount is placed at 40 DEG C, ultrasonic power is 200w's than being to be placed in colloid mill grinding 30min after 1:6 is mixed, obtain Morinda officinalis slurry
Under the conditions of be ultrasonically treated 1h, filter 100 mesh, obtain the first filtrate and the first filter residue；
It B2, by the first filter residue with magnetized water is by weight that 1:5 is mixed, heating is boiled, and continue to heat 25min, filters 100 mesh,
The second filtrate and the second filter residue are obtained, and the second filter residue is immediately placed at -25 DEG C and freezes 5h；
B3, the second filter residue after freezing is thawed, and 4 times of magnetized water of its weight and 1/4 Kiwi berry of its weight is added
Enzyme liquid is uniformly mixed, and then the closed processes 10h at 35 DEG C filters 100 mesh, obtain third filtrate and third filter residue, the Mi
Kiwi berry slurries are made by Kiwi berry pulp in monkey peach enzyme liquid, then by Kiwi berry slurries, honey, probiotics and deionized water according to
Weight ratio is after 10:3:1:40 is mixed, to be sealed by fermentation 7-10 days and obtain, and the probiotics is Bifidobacterium and saccharomycete according to weight
Amount is than being that 1:1 is formed；
B4, third filter residue is used volume fraction extract 2 times for 90% alcohol reflux, the ethyl alcohol of 5-10 times of volume is added every time
Refluxing extraction 2h, and filter, merge the filtrate of refluxing extraction twice, and recycle the ethyl alcohol in filtrate, obtains the 4th filtrate；
B5, the first filtrate, the second filtrate, third filtrate and the 4th filtrate are uniformly mixed to obtain mixed filtrate, are concentrated into mixing filter
The 1/3 of liquid original volume, it is then spray-dried to obtain the Radix Morindae Officinalis extract.
7. the preparation method of permanent tooth tooth-caring toothpaste as described in claim 1, which comprises the following steps:
1) glycerol of above-mentioned parts by weight, sodium carboxymethylcellulose, xanthan gum, sorbierite and deionized water are sequentially added into Manufacturing medicine extract machine
40-50min is stirred in middle progress for the first time, obtains the first mixture；
2) Radix Morindae Officinalis extract, vitamin C, menthol, sweetener and the anti-corrosion of above-mentioned parts by weight are added into the first mixture
Agent carries out second of stirring 20-30min under vacuum environment, obtains the second mixture；
3) the calcined oyster shell shell Ultramicro-powder of above-mentioned parts by weight is added in the second mixture, after carrying out third time stirring 1-1.5h,
The dodecyl sodium sulfate and sodium lauroyl sarcosine for adding above-mentioned parts by weight carry out the 4th stirring 2- under vacuum environment
3h obtains third mixture；
4) essence and colorant of above-mentioned parts by weight, the 5th stirring 0.5-1h, under room temperature are added into third mixture
Closed, storage and aging 2-3h is up to toothpaste；
Wherein, vacuum degree is 0.15-2.06MPa under vacuum environment.
8. the preparation method of permanent tooth tooth-caring toothpaste as claimed in claim 7, which is characterized in that the speed of stirring is for the first time
400r/min；The speed of second of stirring is 500r/min；The speed of third time stirring is 1000r/min；4th stirring
Speed is 300r/min；The speed of 5th stirring is 500r/min.
9. the preparation method of permanent tooth tooth-caring toothpaste as claimed in claim 7, which is characterized in that in step 3) to the second mixture
When middle addition calcined oyster shell shell Ultramicro-powder, while friction aid is added, content is the 15% of calcined oyster shell shell Ultramicro-powder weight, institute
State friction aid the preparation method is as follows:
C1, the acidic mixed solution that pH is 3-4 is prepared, is wherein 15%-20%'s containing mass concentration in acidic mixed solution
Macromolecule mixture, the macromolecule mixture are made of avenabeta glucosan and gelatin with mass ratio for 1:4；
C2, by the acidic mixed solution by electrostatic spinning handle, obtain high polymer nanometer fiber, 45 DEG C of heated-air dryings extremely
Moisture is lower than 15%, crushed 100 mesh, obtains nanofiber powder；
C3, it takes luffa to be cut into small pieces, is placed in boiling water and boils 15min, taking-up fritter luffa, which is immediately placed at -25 DEG C, to be freezed
5h, taking-up are placed on heated-air drying 10h at 60 DEG C, then crush and sieve with 100 mesh sieve to obtain Loofah powder, by Loofah powder and deionization
Water is defibrination after 1:3 mixing by weight, obtains luffa slurry, then the β-Isosorbide-5-Nitrae-endo-xylanase for being 15% with mass fraction
Solution is 5:1 mixing by weight, at 30-35 DEG C, digests 2h, then be placed in heated-air drying 8h at 80 DEG C, crushed 100 mesh
Sieve, obtains loofah fiber powder；
C4, nanofiber powder is uniformly mixed with loofah fiber powder according to mass ratio for 1:4, obtains the friction aid.
10. the preparation method of permanent tooth tooth-caring toothpaste as claimed in claim 7, which is characterized in that mixed to first in step 2)
When closing object addition Radix Morindae Officinalis extract, while being added 8-10 parts of Angelica Dahurica extract.
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Application publication date: 20181211 |
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| RJ01 | Rejection of invention patent application after publication |