CN109363958A - A kind of anti-calculus dentalis toothpaste of containing diatomite - Google Patents
A kind of anti-calculus dentalis toothpaste of containing diatomite Download PDFInfo
- Publication number
- CN109363958A CN109363958A CN201811206314.1A CN201811206314A CN109363958A CN 109363958 A CN109363958 A CN 109363958A CN 201811206314 A CN201811206314 A CN 201811206314A CN 109363958 A CN109363958 A CN 109363958A
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- CN
- China
- Prior art keywords
- toothpaste
- calculus dentalis
- containing diatomite
- diatomite
- calculus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Abstract
The invention belongs to oral cavity cleaning and nursing product field, the anti-calculus dentalis toothpaste of especially a kind of containing diatomite.The anti-calculus dentalis toothpaste of the containing diatomite includes following components by mass percentage: sweetener 0.1-0.3%；Adhesive 0.5-1.8%；PEG 1.0-5.0%；Moisturizer 40-70%；Diatomite 10%；Rubbing agent 10-30%；Titanium dioxide 0.5-3.0%；Foaming agent 1.0%-9.0%；Preservative 0.1-0.20%；Excess water.The partial size of the diatomite is 17-67 μm.The anti-calculus dentalis toothpaste of containing diatomite provided by the invention, can apparent anti-calculus dentalis.
Description
Technical field
The invention belongs to oral cavity cleaning and nursing product field, the anti-calculus dentalis toothpaste of especially a kind of containing diatomite.
Background technique
Calculus dentalis is a kind of calcification for being deposited on facing or dummy surface or just in the bacterial plaque of calcification and soft dirt, by saliva
Calcium salt in liquid or level in gingival sulcus fluid gradually deposits, and is not easy to remove after formation.Two basic steps that calculus dentalis is formed are tooth bacterium
It the formation of spot biomembrane and mineralizes.The initial stage that calculus dentalis is formed is plaque, and initial sialoprotein or glycoprotein are adsorbed to
Facing forms one layer without structure, cell-free dental cuticle, and main component is substantially similar to saliva, contains mucoprotein, sugar
Albumen, blood-group antigen and immunoglobulin, some of them ingredient can promote bacterium to stick refined surface, play the function of receptor
Energy.Then, intraoral bacterium is attached on film successively by substances such as protein, polysaccharide, the lipoteichoicacids on its surface,
Bacterium forms complicated flora, using 10~30 days, bacterial plaque mature reached by sticking and copolymerization is interconnected, is proliferated
To peak.On bacterial plaque surface, because the cell that mineral mineralization, swill and the necrosis in saliva fall off participates in, in bacterial plaque shape
At 2~14 days can calcification, be hardened and form calculus.
Periodontal disease is that the mankind are distributed most wide one of disease.Its Etiological is local stimulation factor, and calculus dentalis is
Cause the main local factor of periodontosis.Calculus dentalis is widely present in population of China, and to safeguard periodontal health, it is fixed to advocate people
Phase cleans one's teeth.Cleaning oral cavity calculus dentalis mainly uses mechanical removal at present, but if without effective method after removing calculus dentalis
Inhibit the formation of calculus dentalis, then can easily damage enamel by the way of mechanical removal for a long time.Thus use chemistry route
Calculus dentalis is inhibited to become the research hotspot of medical circle of oral cavity.Toothpaste is that oral cleaning indispensable in our life is used
Pole the effect of being also equipped with anti-calculus dentalis, is beneficial to the shield in people oral cavity if toothpaste not only has the function of fresh breath by product
Reason.
Summary of the invention
The present invention overcomes existing technique to limit to the anti-calculus dentalis toothpaste, and it is an object of the present invention to provide a kind of containing diatomite.In order to
Realizing the above technical effect, the present invention provides the anti-calculus dentalis toothpaste of containing diatomite by mass percentage, composed of the following components:
The partial size of the diatomite is 17-67 μm.
Preferably, the anti-calculus dentalis toothpaste of the silicon containing diatomite further includes the glacial acetic acid of 1%-3% by mass percentage.
Diatomite is combined with glacial acetic acid, can achieve the effect that better anti-calculus dentalis.
Preferably, the anti-calculus dentalis toothpaste of the silicon containing diatomite further includes 0.5%--1.60%'s by mass percentage
Essence.
Preferably, the sweetener is saccharin sodium.
Preferably, described adhesive be CMC (carboxymethyl cellulose), it is one or more of in xanthan gum.
Preferably, described adhesive is CMC and the mass ratio of xanthan gum is 2-6:1-3.
Preferably, moisturizer is sorbierite.
Preferably, the rubbing agent is silica.
Preferably, the foaming agent is laruyl alcohol sodium sulfovinate.
In short, anti-calculus dentalis effect toothpaste of all natural diatomite functional component provided by the invention is resistant to a certain extent
Calculus dentalis especially combines diatomite and glacial acetic acid, better effect.
Specific embodiment
Below with reference to embodiment, the invention will be further described:
The partial size of diatomite used in following embodiment is 50 μm or so.
Embodiment 1
Following percentage is mass percent:
One, premix:
1, water-soluble 0.2% saccharin sodium, 0.4% xanthan gum, 2%PEG are dissolved in 16.25% water and are made pre- mixed
Aqueous solution.
2,0.8%CMC is uniformly mixed with 15% silica, 2% titanium dioxide.
3,0.15% methyl hydroxybenzoate is dissolved in 1.2% essence
Two, lotions:
1. 50% sorbierite and pre- mixed aqueous solution are put into simultaneously in cream pot processed,
2. the vacuum holding -0.095Pa in cream pot processed, under the conditions of 980 revs/min of mixing speed, by pre- mixed methyl
In the suckings cream pot such as sodium cellulosate and silica, titanium dioxide, stir 15 minutes.
3. 10% diatomite is sucked in cream pot processed, stir 10 minutes
4 2% laruyl alcohol sodium sulfovinates of investment, are stirred 10 minutes
5. sucking 1.2% essence, after five minutes, uniformly cream processed terminates lotion for stirring.
Embodiment 2
Following percentage is mass percent:
One, premix:
1, water-soluble 0.2% saccharin sodium, 0.4% xanthan gum, 2%PEG, 2% glacial acetic acid are dissolved in 14.25% water
Pre- mixed aqueous solution is made.
2,0.8%CMC is uniformly mixed with 15% silica, 2% titanium dioxide.
3,0.15% methyl hydroxybenzoate is dissolved in 1.2% essence
Two, lotions:
1. 50% sorbierite and pre- mixed aqueous solution are put into simultaneously in cream pot processed,
2. the vacuum holding -0.095Pa in cream pot processed, under the conditions of 980 revs/min of mixing speed, by pre- mixed methyl
In the suckings cream pot such as sodium cellulosate and silica, titanium dioxide, stir 15 minutes.
3. 10% diatomite is sucked in cream pot processed, stir 10 minutes
4 2% laruyl alcohol sodium sulfovinates of investment, are stirred 10 minutes
5. sucking 1.2% essence, after five minutes, uniformly cream processed terminates lotion for stirring.
Comparative example 1:
One, premix:
1, water-soluble 0.2% saccharin sodium, 0.4% xanthan gum, 2%PEG are dissolved in 21.25% water and are made pre- mixed
Aqueous solution.
2,0.8%CMC is uniformly mixed with 20% silica, 2% titanium dioxide.
3,0.15% methyl hydroxybenzoate is dissolved in 1.2% essence
Two, lotions:
1. 50% sorbierite and pre- mixed aqueous solution are put into simultaneously in cream pot processed,
2. the vacuum holding -0.095Pa in cream pot processed, under the conditions of 980 revs/min of mixing speed, by pre- mixed methyl
In the suckings cream pot such as sodium cellulosate and silica, titanium dioxide, stir 15 minutes.
3 2% laruyl alcohol sodium sulfovinates of investment, are stirred 10 minutes
4. sucking 1.2% essence, after five minutes, uniformly cream processed terminates lotion for stirring.
Test method:
1, it summarizes
Subject 105 are randomly choosed, wherein male 52, women 53, average age 46.2 years old.Select subject's
Condition are as follows: in order (women is non-pregnancy, nursing period), subject's baseline calculus indices are greater than 7.0 to whole body health,
It can further consultation on time；Subject does not have allergies to individual health care articles (including toothpaste) or its ingredient；It is not participated in simultaneously
It is similar to experimental study.
Test uses double-blind study, this ensure that the authenticity of test.Test uses Volpe-Mamhold index assessment tooth
Calculus situation, the results show that anti-calculus dentalis effect toothpaste group Volpe-Mamhold index of containing diatomite is equal using March, June
It reduces, Volpe-Mamhold index variation has statistical difference (P < 0.05).And use the blank of not containing diatomite functional component
Toothpaste group Volpe-Mamhold index variation does not have statistical difference (P > 0.05).In test, not yet discovery subject has not
Good reaction.
2, specific method:
(1) for the reliability of guarantee test result, every subject passes through 2 months elution phases, i.e., unified to use
Blank toothpaste without pure silicon diatomaceous earth functional component is brushed teeth, three times a day.
(2) subject is randomly divided into tri- groups of A, B, C, every group 35.A group: toothpaste is prepared using embodiment 1, B group: is made
The toothpaste prepared with embodiment 2, C group: the toothpaste prepared using comparative example 1.
3 experiment processes:
(1) baseline inspection: preliminary investigation is carried out to subject, it is desired to which baseline calculus indices are greater than 7.0.Calculus dentalis amount inspection:
Using Volpe-Mamhold index assessment calculus dentalis situation, using the standard periodontal probe for having millimeter scale when inspection, by tooth
After lingual surface is dry, the lingual surface of 6 lower labial teeths is checked.Probe is placed on the middle line of lingual surface, parallel with tooth long axile, measures gum upper tooth knot
The maximum height of stone；Probe measures the maximum height of lingual surface distal margin calculus dentalis by the mesio-incisal angle of tooth；In remote
Corner cut measures the maximum height of lingual surface mesial margin calculus dentalis.
(2) full mouth scaling is carried out to the subject for being included in test, removes calculus dentalis, and polish facing, then using specified
Toothpaste.It is required that subject brushes teeth 2 times (each 1 time early, late) daily, each 3min.It must not be used during test other any
Dental care product, such as toothpaste, toothbrush and gargle, the dental floss of other types.
(3) it checks: when testing March, June, subject's calculus dentalis amount being carried out according to the standard and program of baseline inspection
It reevaluates.
5. statistical analysis: data carry out statistical procedures using SPSS10.0.
Test result
1. the ordinary circumstance of test front and back subject
Participating in the subject tested, totally 105 people, 101 people complete final clinical test, 4 people person lost to follow-up (being women)
The reason of exiting test is unrelated with using toothpaste.In test, not yet discovery subject has undesirable reaction.
2, test front and back Volpe-Mamhold index variation situation, is shown in Table.
Volpe-Mamhold index variation situation before and after watch test
Through statistical analysis, Volpe-Mamhold index does not have statistical difference (P > between tri- groups of A, B, C before testing
0.05).It tests March, June, A group and B group Volpe-Mamhold index are below C group (P < 0.05), before being significantly lower than test
Volpe-Mamhold index (P < 0.05).After testing March, June, B group Volpe-Mamhold index is lower than A group.And it tests
The C group Volpe-Mamhold index no significant difference (P > 0.05) of front and back.
Conclusion:
Calculus dentalis is in close relations with periodontosis, and epidemiological survey shows between calculus dentalis amount and the inflammation of gum in just
It is related.The pathogenic effects of calculus dentalis mainly since its surface can often form the bacterial plaque of non-mineralising, can stimulate gum to cause inflammation,
In addition calculus dentalis itself is hard coarse, has mechanical stimulus to gum, is the weight of bleeding gums, oral pocket intensification, absorption of alveolar bone
Factor is wanted, therefore removes calculus dentalis important role.
This test uses double-blind study, this ensure that the authenticity of test.Test uses Volpe-Mamhold index assessment
Calculus dentalis situation, the results show that anti-calculus dentalis effect A, the B toothpaste group Volpe-Mamhold of containing diatomite refers to using March, June
Number reduces, and Volpe-Mamhold index variation has statistical difference (P < 0.05).And use the blank of not containing diatomite ingredient
Toothpaste group Volpe-Mamhold index variation does not have statistical difference (P > 0.05).In test, not yet discovery subject has not
Good reaction.
In short, by experiments have shown that, containing only a kind of anti-calculus dentalis effect toothpaste sample of all natural diatomite functional component
It is resistant to calculus dentalis to a certain extent, especially combines diatomite and glacial acetic acid, better effect.
The above is presently preferred embodiments of the present invention, and exemplary illustration and help further understand the present invention.But
Embodiment detail does not represent whole technical solutions under present inventive concept, therefore do not answer merely to illustrate the present invention
It is interpreted as the restriction to technical solution of the present invention.It is all not depart from the equivalent of the lower completion of spirit disclosed in this invention or repair
Change, all should belong to the scope of protection of the invention.
Claims (10)
1. a kind of anti-calculus dentalis toothpaste of containing diatomite, it is characterised in that: the anti-calculus dentalis toothpaste of the containing diatomite presses quality
Percentage includes following components:
The partial size of the diatomite is 17-67 μm.
2. according to the anti-calculus dentalis toothpaste of containing diatomite described in right 1, it is characterised in that: the anti-tooth knot of the silicon containing diatomite
Stone toothpaste further includes the glacial acetic acid of 1%-3% by mass percentage.
3. according to the anti-calculus dentalis toothpaste of containing diatomite described in right 1, it is characterised in that: the anti-tooth knot of the silicon containing diatomite
Stone toothpaste further includes the essence of 0.5%--1.60% by mass percentage.
4. according to the anti-calculus dentalis toothpaste of containing diatomite described in right 1, it is characterised in that: the sweetener is saccharin sodium.
5. according to the anti-calculus dentalis toothpaste of containing diatomite described in right 1, it is characterised in that: described adhesive CMC, xanthan gum
Middle one or more.
6. according to the anti-calculus dentalis toothpaste of containing diatomite described in right 4, it is characterised in that: described adhesive is CMC and xanthan
The mass ratio of glue is 2-6:1-3.
7. according to the anti-calculus dentalis toothpaste of containing diatomite described in right 1, it is characterised in that: the moisturizer is sorbierite.
8. according to the anti-calculus dentalis toothpaste of containing diatomite described in right 1, it is characterised in that: the rubbing agent is silica.
9. according to the anti-calculus dentalis toothpaste of containing diatomite described in right 1, it is characterised in that: the foaming agent is laruyl alcohol sulfuric acid
Ester sodium.
10. according to the anti-calculus dentalis toothpaste of the containing diatomite of right 1, it is characterised in that: the preservative is methyl hydroxybenzoate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811206314.1A CN109363958A (en) | 2018-10-17 | 2018-10-17 | A kind of anti-calculus dentalis toothpaste of containing diatomite |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811206314.1A CN109363958A (en) | 2018-10-17 | 2018-10-17 | A kind of anti-calculus dentalis toothpaste of containing diatomite |
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| CN109363958A true CN109363958A (en) | 2019-02-22 |
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| CN201811206314.1A Pending CN109363958A (en) | 2018-10-17 | 2018-10-17 | A kind of anti-calculus dentalis toothpaste of containing diatomite |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840194A (en) * | 2020-08-13 | 2020-10-30 | 广州市名俐日用化工有限公司 | Whitening and stain-removing toothpaste containing diatomite and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899437A (en) * | 1973-03-12 | 1975-08-12 | Barrie F Regan | Denture cleaning composition containing phosphoric acid |
| DE3233150A1 (en) * | 1982-09-07 | 1984-03-08 | Horst Dr.med. 4300 Essen Bisler | Tartar remover |
| CN101485617A (en) * | 2008-01-18 | 2009-07-22 | 邢津维 | Tooth-cleaning powder using bergmeal as raw material |
| CN105816345A (en) * | 2016-04-20 | 2016-08-03 | 青岛大学附属医院 | Functional toothpaste preparation for preventing and treating periodontitis |
| CN107184462A (en) * | 2017-05-24 | 2017-09-22 | 国家林业局泡桐研究开发中心 | A kind of halitosis-removing toothpaste companion and preparation method thereof |
| CN107802506A (en) * | 2017-10-11 | 2018-03-16 | 苏州市金茂日用化学品有限公司 | A kind of toothpaste for removing abnormal flavor in oral cavity containing diatomite |
-
2018
- 2018-10-17 CN CN201811206314.1A patent/CN109363958A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899437A (en) * | 1973-03-12 | 1975-08-12 | Barrie F Regan | Denture cleaning composition containing phosphoric acid |
| DE3233150A1 (en) * | 1982-09-07 | 1984-03-08 | Horst Dr.med. 4300 Essen Bisler | Tartar remover |
| CN101485617A (en) * | 2008-01-18 | 2009-07-22 | 邢津维 | Tooth-cleaning powder using bergmeal as raw material |
| CN105816345A (en) * | 2016-04-20 | 2016-08-03 | 青岛大学附属医院 | Functional toothpaste preparation for preventing and treating periodontitis |
| CN107184462A (en) * | 2017-05-24 | 2017-09-22 | 国家林业局泡桐研究开发中心 | A kind of halitosis-removing toothpaste companion and preparation method thereof |
| CN107802506A (en) * | 2017-10-11 | 2018-03-16 | 苏州市金茂日用化学品有限公司 | A kind of toothpaste for removing abnormal flavor in oral cavity containing diatomite |
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| Title |
|---|
| 汪多仁编著: "《现代日用化工产品》", 31 March 2000, 冶金工业出版社 * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840194A (en) * | 2020-08-13 | 2020-10-30 | 广州市名俐日用化工有限公司 | Whitening and stain-removing toothpaste containing diatomite and preparation method thereof |
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