CN103989599A - Chinese herbal medicine toothpaste capable of diminishing inflammation and stopping bleeding - Google Patents
Chinese herbal medicine toothpaste capable of diminishing inflammation and stopping bleeding Download PDFInfo
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Abstract
The invention provides Chinese herbal medicine toothpaste capable of diminishing inflammation and stopping bleeding. The toothpaste comprises following components by weight: 0.1-0.2 part of a radix scutellariae extract product, 0.5-2 parts of a pudilan extract product, 2-4 parts of polyethylene glycol-400, 8-16 parts of glycerin, 30-50 parts of sorbitol, 0.1-1 part of xanthan gum, 0.1-0.5 part of sodium carboxymethylcellulose, 0.1-0.5 part of saccharin, 2-3 parts of sodium dodecylsulfate, 8-15 parts of 115 type silica gel, 5-10 parts of 153 type silica gel, 3-8 parts of 203 type silica gel, 0.5-1.5 parts of essence, 0.05 part of sodium propylparaben, 0.05 part of sodium butyl p-hydroxybenzoate and 0.04 part of sodium hydroxide, with the balance being water and the total amount being 100 g.
Description
Technical field
The present invention relates to a kind of Chinese herbal toothpaste of anti-inflammation hemostasia.
Background technology
The destructive process of periodontitis is by the interactional result of complicated molecular mechanism between bacterial plaque and host.Host's defence process is divided into nonspecific inflammatory reaction and specific immune response (comprising humoral immunization, cellular immunization and complement system).Periodontitis can be described as a kind of by bacterial immune inflammation disease, and its generation, development are relevant with the participation of immunocyte and correlation factor thereof.Periodontitis main inducing bacterial plaque, tartar, traumatogenic articulation, bacterial plaque adheres to the micropopulation of dental surface, can not be with gargling, the removal such as water flushing.Tartar refers to the bacterial plaque that is deposited on the mineralising on facing, according to its deposition site and character, is divided into two kinds of supragingival calculus and subgingival calculuss.(1) supragingival calculus is positioned on facing more than gum edge, and naked eyes can directly be seen.In neck portion, deposition is more, particularly at glandulae salivariae majores catheter opening opposite position, as more in the tongue side deposition of the cheek side of maxillary molar and mandibular anterior teeth.In supragingival calculus, the main source of inorganic salt is the mineral salts such as calcium in saliva, phosphorus.(2) subgingival calculus be positioned at that gum edge is following, on the root face of gingival pocket or periodontal pocket, naked eyes can not be looked at straight, must detect with probe, can know its deposition site and deposition.In subgingival calculus, the main source of inorganic salt is level in gingival sulcus fluid.The harm of tartar to periodontal tissue is mainly to have formed bacterial plaque to adhere to the good environment with bacteria breed.When interlock, if gmatjpdumamics is excessive or direction is abnormal, surmounted making a concerted effort that periodontal tissue can bear, cause periodontal tissue that the interlock of damage occurs, be called traumatogenic articulation.Contact morning when traumatogenic articulation comprises interlock, tooth close interference, bruxism etc.Other factors such as food impaction, bad dummy, mouth breathing also impel the inflammation of periodontal tissue to occur.Early symptom is not obvious, and patient often only has the performance of Secondary cases gingival hemorrhage or halitosis, similar to symptoms of gingivitis.During inspection, swelling, the matter of visible gum edge, gum nipple and attached gingiva are soft, are peony or kermesinus, and spy is examined easily hemorrhage., there is following symptoms in the further diffusion along with inflammation: 1. periodontal pocket forms, and due to the expansion of inflammation, periodontal membrane is destroyed, and alveolar bone absorbs gradually, and gingiva is separated with root of the tooth, and gingival sulcus is deepened and formation periodontal pocket.Available probe is surveyed depth of pocket.2. periodontal pyorrhea, periodontal pocket wall has ulcer and struvite granulation tissue to form, and in bag, has purulent secretion to retain, thus flicking gingiva, visible pyorrhea.And often there is a halitosis.3. odontoseisis, because periodontal tissue is destroyed, when particularly frontal resorption increases the weight of, supports tooth strength not enough, occurs the phenomenons such as odontoseisis, displacement.Now patient often feels that interlock is unable, dull pain, and gingival hemorrhage and halitosis increase the weight of.When Abwehrkraft des Koepers reduction, periodontal pocket sepage inadequate drainage, can form periodontal abscess, be that periodontitis develops into late period, there is a common concomitant symptom of dark periodontal pocket.Now gingiva is oval projection, rubescent swelling, surface-brightening; Tooth mobility increases, and kowtows pain; Patient is with the violent jumping pain in part.Meanwhile, patient can have fervescence, general malaise, the symptoms such as submandibular lymph nodes enlargement, tenderness.
The blue antiinflammatory oral liquid in Pu ground is curative effect heat-clearing and toxic substances removing, anti-inflammation detumescence.For furuncle and phyma, parotitis, pharyngitis, tonsillitis etc.
Chinese herbal toothpaste prevention and the existing Related product for the treatment of periodontitis, still, because Chinese herbal medicine mucosa penetration study does not still go deep into, the medicinal herb components in toothpaste is very few to be absorbed at periodontal, causes Chinese herbal toothpaste not remarkable to the effect of periodontitis.At present, the research of the Penetration enhancing effect of Chinese medicine mainly concentrates on Chinese medicine the short of chemicals is oozed to effect aspect, and mutually urging between relevant Chinese medicine oozed effect report seldom.This may be because more, the complicated component of compound Chinese medicinal preparation flavour of a drug, for medicine quantitative study in vivo and in vitro brings certain difficulty, but also point out short between our Chinese traditional compound medicine Chinese medicine to ooze research simultaneously, has larger potentiality.
Summary of the invention
The invention provides a kind of Chinese herbal toothpaste of anti-inflammation hemostasia, count by weight, it comprises following composition:
Radix Scutellariae extract 0.1-0.2 part
The blue extract 0.5-2 part in Pu ground
PEG-4000 2-4 part
Glycerol 8-16 part
Sorbitol 30-50 part
Xanthan gum 0.1-1 part
Sodium carboxymethyl cellulose 0.1-0.5 part
Glucide 0.1-0.5 part
Sodium lauryl sulphate 2-3 part
Dioxide/silica gel 115 type 8-15 parts
Dioxide/silica gel 153 type 5-10 parts
Dioxide/silica gel 203 type 3-8 parts
Essence 0.5-1.5 part
0.05 part of soluble propylhydroxybenzoate
0.05 part of nipabutyl sodium
0.04 part of sodium hydroxide
Water is to 100g.
Further, the Chinese herbal toothpaste of described anti-inflammation hemostasia, counts by weight, and it consists of the following composition:
Herba Clinopodii extract 0.1-0.2 part
Radix Scutellariae extract 0.1-0.2 part
The blue extract 0.5-2 part in Pu ground
PEG-4000 2-4 part
Glycerol 8-16 part
Sorbitol 30-50 part
Xanthan gum 0.1-1 part
Sodium carboxymethyl cellulose 0.1-0.5 part
Glucide 0.1-0.5 part
Sodium lauryl sulphate 2-3 part
Dioxide/silica gel 115 type 8-15 parts
Dioxide/silica gel 153 type 5-10 parts
Dioxide/silica gel 203 type 3-8 parts
Essence 0.5-1.5 part
0.05 part of soluble propylhydroxybenzoate
0.05 part of nipabutyl sodium
0.04 part of sodium hydroxide
Water is to 100g.
Further, the Chinese herbal toothpaste of described anti-inflammation hemostasia, counts by weight, and it consists of the following composition:
0.14 part of Herba Clinopodii extract
0.17 part of Radix Scutellariae extract
1 part of the blue extract in Pu ground
3 parts of PEG-4000s
11 parts of glycerol
43 parts of sorbitol
0.6 part of xanthan gum
0.3 part of sodium carboxymethyl cellulose
0.2 part, glucide
2.5 parts of sodium lauryl sulphates
11 parts, dioxide/silica gel 115 type
8 parts, dioxide/silica gel 153 type
5 parts, dioxide/silica gel 203 type
1.1 parts, essence
0.05 part of soluble propylhydroxybenzoate
0.05 part of nipabutyl sodium
0.04 part of sodium hydroxide
Water to 100 part.
The present invention also provides a kind of preparation method of Chinese herbal toothpaste of anti-inflammation hemostasia,
Take soluble propylhydroxybenzoate, 1% purified water normal-temperature dissolution for nipabutyl sodium, Radix Scutellariae extract 0.1-0.2 part, the blue extract 0.5-2 part in Pu ground, glucide, sodium hydroxide, stir with 50 ℃ of dissolvings of purified water by surplus,
Xanthan gum, sodium carboxymethyl cellulose join in PEG-4000, be stirred to and be uniformly dispersed, add glycerol, sorbitol, stir, the aqueous solution that adds medicine and glucide, stirs, then adds soluble propylhydroxybenzoate, butoben sodium water solution, after stirring, standing over night, obtains even colloid, after colloid stirs, add successively silica 1 53 types, dioxide/silica gel 115 types, dioxide/silica gel 203 types, after stirring, add sodium lauryl sulphate and essence, stir, evacuation, Zhen Kong Du≤0.094MPa.
The preparation method of the Chinese herbal toothpaste of described anti-inflammation hemostasia,
Take soluble propylhydroxybenzoate, 1% purified water normal-temperature dissolution for nipabutyl sodium, 0.14 part of Herba Clinopodii extract, 0.17 part of Radix Scutellariae extract, 1 part of the blue extract in Pu ground, glucide, sodium hydroxide, stir with 50 ℃ of dissolvings of purified water by surplus,
Xanthan gum, sodium carboxymethyl cellulose join in PEG-4000, be stirred to and be uniformly dispersed, add glycerol, sorbitol, stir, the aqueous solution that adds medicine and glucide, stirs, then adds soluble propylhydroxybenzoate, butoben sodium water solution, after stirring, standing over night, obtains even colloid, after colloid stirs, add successively silica 1 53 types, dioxide/silica gel 115 types, dioxide/silica gel 203 types, after stirring, add sodium lauryl sulphate and essence, stir, evacuation, Zhen Kong Du≤0.094MPa.
The present invention has furtherd investigate Pu Dilan, Radix Scutellariae, and Herba Clinopodii extract mucosa permeability, has the effect of oozing of mutually urging between said medicine.Significantly improved medicinal herb components few in periodontal absorption, Chinese herbal toothpaste is significantly improved the effect of periodontitis.
The specific embodiment
embodiment 1
Composition of raw materials consumption is in g
Herba Clinopodii extract 0.14
Radix Scutellariae extract 0.17
The blue extract 1 in Pu ground
PEG-4000 3
Glycerol 11
Sorbitol 43
Xanthan gum 0.6
Sodium carboxymethyl cellulose 0.3
Glucide 0.2
Sodium lauryl sulphate 2.5
Dioxide/silica gel 115 types 11
Dioxide/silica gel 153 types 8
Dioxide/silica gel 203 types 5
Essence 1.1
Soluble propylhydroxybenzoate 0.05
Nipabutyl sodium 0.05
Sodium hydroxide 0.04
Water is to 100g;
Take soluble propylhydroxybenzoate, for nipabutyl sodium, 1% purified water (room temperature) is dissolved; Medicine, glucide, sodium hydroxide dissolve by surplus purified water (50 ℃), stir.
Xanthan gum, sodium carboxymethyl cellulose join in PEG-4000, be stirred to and be uniformly dispersed, add glycerol, sorbitol, stir, add the aqueous solution of medicine and glucide, stir, add again soluble propylhydroxybenzoate, butoben sodium water solution, after stirring, standing over night, obtains even colloid.After colloid stirs, add successively silica 1 53 types, dioxide/silica gel 115 types, dioxide/silica gel 203 types, after stirring, add sodium lauryl sulphate and essence, stir, evacuation (Zhen Kong Du≤0.094MPa).
embodiment 2
Composition of raw materials consumption is in g
Herba Clinopodii extract 0.14
Radix Scutellariae extract 0.17
The blue extract 1 in Pu ground
PEG-4000 3
Glycerol 11
Sorbitol 43
Xanthan gum 0.6
Sodium carboxymethyl cellulose 0.3
Glucide 0.19
Sodium lauryl sulphate 2.5
Dioxide/silica gel 115 types 11
Dioxide/silica gel 153 types 8
Dioxide/silica gel 203 types 5
Essence 1.1
Soluble propylhydroxybenzoate 0.05
Nipabutyl sodium 0.05
Sodium hydroxide 0.04
Water is to 100g;
Take soluble propylhydroxybenzoate, for nipabutyl sodium, 1% purified water (room temperature) is dissolved; Medicine, glucide, sodium hydroxide dissolve by surplus purified water (50 ℃), stir.
Xanthan gum, sodium carboxymethyl cellulose join in PEG-4000, be stirred to and be uniformly dispersed, add glycerol, sorbitol, stir, add the aqueous solution of medicine and glucide, stir, add again soluble propylhydroxybenzoate, butoben sodium water solution, after stirring, standing over night, obtains even colloid.After colloid stirs, add successively silica 1 53 types, dioxide/silica gel 115 types, dioxide/silica gel 203 types, after stirring, add sodium lauryl sulphate and essence, stir, evacuation (Zhen Kong Du≤0.094MPa).
embodiment 3
Composition of raw materials consumption is in g
Radix Scutellariae extract 0.17
The blue extract 1 in Pu ground
PEG-4000 3
Glycerol 11
Sorbitol 43
Xanthan gum 0.6
Sodium carboxymethyl cellulose 0.3
Glucide 0.2
Sodium lauryl sulphate 2.5
Dioxide/silica gel 115 types 11
Dioxide/silica gel 153 types 8
Dioxide/silica gel 203 types 5
Essence 1.1
Soluble propylhydroxybenzoate 0.05
Nipabutyl sodium 0.05
Sodium hydroxide 0.04
Water is to 100g.
Take soluble propylhydroxybenzoate, for nipabutyl sodium, 1% purified water (room temperature) is dissolved; Medicine, glucide, sodium hydroxide dissolve by surplus purified water (50 ℃), stir.
Xanthan gum, sodium carboxymethyl cellulose join in PEG-4000, be stirred to and be uniformly dispersed, add glycerol, sorbitol, stir, add the aqueous solution of medicine and glucide, stir, add again soluble propylhydroxybenzoate, butoben sodium water solution, after stirring, standing over night, obtains even colloid.After colloid stirs, add successively silica 1 53 types, dioxide/silica gel 115 types, dioxide/silica gel 203 types, after stirring, add sodium lauryl sulphate and essence, stir, evacuation (Zhen Kong Du≤0.094MPa).
test example 1
18 of the healthy wister male rats of 200-240g, are divided into 3 groups by table of random number method is parallel, after the 4mg of local application, respectively at after administration 2,4,8h gets blood and de-cervical vertebra is put to death rat (6 rats of each time point), with 75% ethanol, wipes clean paster position skin, peels off right shoulder joint, carefully reject muscle, precision takes 2g, pulverizes, be placed in glass tubing, add 4mlPBS liquid vortex oscillation 30s, sonic oscillation 2min is centrifugal, draw supernatant, to be measured.
Rat single is used after Chinese herbal toothpaste 2g of the present invention, the Determination of baicalin of each time point blood plasma and local joint
test example 2
With 200 artificial subjects of suffering from the various oral diseases such as gingival hemorrhage, gingival swelling and pain, oral ulcer, gingival atrophy, periodontitis, adopting for each person every day sooner or later adopts this toothpaste to brush teeth once, a 2g left and right, continuously after 8-10 days, after experimenter uses toothpaste of the present invention, 98% patient takes effect obviously, 1-2% patient takes effect generally, and 1%-2% patient shows improvement.
Above-mentioned detailed description is for the illustrating of one of them possible embodiments of the present invention, and this embodiment is not in order to limit the scope of the claims of the present invention, and the equivalence that all the present invention of disengaging do is implemented or change, all should be contained in the scope of technical solution of the present invention.
Claims (5)
1. a Chinese herbal toothpaste for anti-inflammation hemostasia, is characterized in that, counts by weight, and it comprises following composition:
Radix Scutellariae extract 0.1-0.2 part
The blue extract 0.5-2 part in Pu ground
PEG-4000 2-4 part
Glycerol 8-16 part
Sorbitol 30-50 part
Xanthan gum 0.1-1 part
Sodium carboxymethyl cellulose 0.1-0.5 part
Glucide 0.1-0.5 part
Sodium lauryl sulphate 2-3 part
Dioxide/silica gel 115 type 8-15 parts
Dioxide/silica gel 153 type 5-10 parts
Dioxide/silica gel 203 type 3-8 parts
Essence 0.5-1.5 part
0.05 part of soluble propylhydroxybenzoate
0.05 part of nipabutyl sodium
0.04 part of sodium hydroxide
Water is to 100g.
2. the Chinese herbal toothpaste of anti-inflammation hemostasia as claimed in claim 1, is characterized in that, counts by weight, and it consists of the following composition:
Herba Clinopodii extract 0.1-0.2 part
Radix Scutellariae extract 0.1-0.2 part
The blue extract 0.5-2 part in Pu ground
PEG-4000 2-4 part
Glycerol 8-16 part
Sorbitol 30-50 part
Xanthan gum 0.1-1 part
Sodium carboxymethyl cellulose 0.1-0.5 part
Glucide 0.1-0.5 part
Sodium lauryl sulphate 2-3 part
Dioxide/silica gel 115 type 8-15 parts
Dioxide/silica gel 153 type 5-10 parts
Dioxide/silica gel 203 type 3-8 parts
Essence 0.5-1.5 part
0.05 part of soluble propylhydroxybenzoate
0.05 part of nipabutyl sodium
0.04 part of sodium hydroxide
Water is to 100g.
3. the Chinese herbal toothpaste of anti-inflammation hemostasia as claimed in claim 2, is characterized in that, counts by weight, and it consists of the following composition:
0.14 part of Herba Clinopodii extract
0.17 part of Radix Scutellariae extract
1 part of the blue extract in Pu ground
3 parts of PEG-4000s
11 parts of glycerol
43 parts of sorbitol
0.6 part of xanthan gum
0.3 part of sodium carboxymethyl cellulose
0.2 part, glucide
2.5 parts of sodium lauryl sulphates
11 parts, dioxide/silica gel 115 type
8 parts, dioxide/silica gel 153 type
5 parts, dioxide/silica gel 203 type
1.1 parts, essence
0.05 part of soluble propylhydroxybenzoate
0.05 part of nipabutyl sodium
0.04 part of sodium hydroxide
Water to 100 part.
4. a preparation method for the Chinese herbal toothpaste of the anti-inflammation hemostasia described in claim 1-3, is characterized in that,
Take soluble propylhydroxybenzoate, 1% purified water normal-temperature dissolution for nipabutyl sodium, Radix Scutellariae extract 0.1-0.2 part, the blue extract 0.5-2 part in Pu ground, glucide, sodium hydroxide, stir with 50 ℃ of dissolvings of purified water by surplus,
Xanthan gum, sodium carboxymethyl cellulose join in PEG-4000, be stirred to and be uniformly dispersed, add glycerol, sorbitol, stir, the aqueous solution that adds medicine and glucide, stirs, then adds soluble propylhydroxybenzoate, butoben sodium water solution, after stirring, standing over night, obtains even colloid, after colloid stirs, add successively silica 1 53 types, dioxide/silica gel 115 types, dioxide/silica gel 203 types, after stirring, add sodium lauryl sulphate and essence, stir, evacuation, Zhen Kong Du≤0.094MPa.
5. a preparation method for the Chinese herbal toothpaste of the anti-inflammation hemostasia described in claim 1-3, is characterized in that,
Take soluble propylhydroxybenzoate, 1% purified water normal-temperature dissolution for nipabutyl sodium, 0.14 part of Herba Clinopodii extract, 0.17 part of Radix Scutellariae extract, 1 part of the blue extract in Pu ground, glucide, sodium hydroxide, stir with 50 ℃ of dissolvings of purified water by surplus,
Xanthan gum, sodium carboxymethyl cellulose join in PEG-4000, be stirred to and be uniformly dispersed, add glycerol, sorbitol, stir, the aqueous solution that adds medicine and glucide, stirs, then adds soluble propylhydroxybenzoate, butoben sodium water solution, after stirring, standing over night, obtains even colloid, after colloid stirs, add successively silica 1 53 types, dioxide/silica gel 115 types, dioxide/silica gel 203 types, after stirring, add sodium lauryl sulphate and essence, stir, evacuation, Zhen Kong Du≤0.094MPa.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106361642A (en) * | 2016-10-26 | 2017-02-01 | 济川药业集团有限公司 | Pudilan mouth wash and preparation process thereof |
| CN106420512A (en) * | 2016-12-15 | 2017-02-22 | 柳州两面针股份有限公司 | Application of compound traditional Chinese medicine extract in preparing oral care healthcare products |
| CN107693438A (en) * | 2017-11-27 | 2018-02-16 | 大连丹特生物技术有限公司 | A kind of daystart toothpaste and preparation method thereof |
| CN107753390A (en) * | 2017-06-15 | 2018-03-06 | 青岛海芬健康产业科技有限公司 | A kind of anti-inflammation toothpaste and preparation method thereof |
| CN107951766A (en) * | 2017-12-05 | 2018-04-24 | 安庆乘风制药有限公司 | Chinese herbal toothpaste composition containing Duanxueliu extract |
| CN108379139A (en) * | 2018-03-07 | 2018-08-10 | 济川药业集团有限公司 | A kind of toothpaste and its preparation method and application of anti-treating dental ulcer |
| CN109044916A (en) * | 2018-10-10 | 2018-12-21 | 广东心宝药业科技有限公司 | A kind of Pudilan toothpaste and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106361642A (en) * | 2016-10-26 | 2017-02-01 | 济川药业集团有限公司 | Pudilan mouth wash and preparation process thereof |
| CN106361642B (en) * | 2016-10-26 | 2019-12-10 | 济川药业集团有限公司 | Pudilan mouthwash and preparation process thereof |
| CN106420512A (en) * | 2016-12-15 | 2017-02-22 | 柳州两面针股份有限公司 | Application of compound traditional Chinese medicine extract in preparing oral care healthcare products |
| CN107753390A (en) * | 2017-06-15 | 2018-03-06 | 青岛海芬健康产业科技有限公司 | A kind of anti-inflammation toothpaste and preparation method thereof |
| CN107693438A (en) * | 2017-11-27 | 2018-02-16 | 大连丹特生物技术有限公司 | A kind of daystart toothpaste and preparation method thereof |
| CN107951766A (en) * | 2017-12-05 | 2018-04-24 | 安庆乘风制药有限公司 | Chinese herbal toothpaste composition containing Duanxueliu extract |
| CN108379139A (en) * | 2018-03-07 | 2018-08-10 | 济川药业集团有限公司 | A kind of toothpaste and its preparation method and application of anti-treating dental ulcer |
| CN108379139B (en) * | 2018-03-07 | 2020-12-08 | 济川药业集团有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method and application thereof |
| CN109044916A (en) * | 2018-10-10 | 2018-12-21 | 广东心宝药业科技有限公司 | A kind of Pudilan toothpaste and preparation method thereof |
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| CN103989599B (en) | 2016-07-06 |
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Inventor after: Cao Longxiang Inventor after: Dong Zibo Inventor after: Shao Jianguo Inventor after: Gu Yanfei Inventor before: Dong Longxiang Inventor before: Dong Zibo Inventor before: Shao Jianguo Inventor before: Gu Yanfei |
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Effective date of registration: 20211217 Address after: 225441 6f-1, No. 318, Yongfeng South Road, Huangqiao Town, Taixing City, Taizhou City, Jiangsu Province Patentee after: Jiangsu Pudilan Daily Chemical Co.,Ltd. Address before: 225441 Jiangsu Taizhou Taixing Daqing West Road baotawan Jichuan Pharmaceutical Group Co., Ltd Patentee before: JUMPCAN PHARMACEUTICAL GROUP Co.,Ltd. |
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