CN106361642A - Pudilan mouth wash and preparation process thereof - Google Patents
Pudilan mouth wash and preparation process thereof Download PDFInfo
- Publication number
- CN106361642A CN106361642A CN201610946205.8A CN201610946205A CN106361642A CN 106361642 A CN106361642 A CN 106361642A CN 201610946205 A CN201610946205 A CN 201610946205A CN 106361642 A CN106361642 A CN 106361642A
- Authority
- CN
- China
- Prior art keywords
- ground
- blue
- collutory
- extract
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to mouth wash, and particularly discloses Pudilan mouth wash which comprises sorbitol, edible alcohol, glycerin, polyethylene glycol-400, sodium citrate, PEG (polyethylene glycol)-hydrogenated castor oil, poloxamer 127, xylitol, Pudilan extracts, radix scutellariae extracts, sodium fluoride, cetyl pyridinium chloride, peppermint essence, methylparaben and purified water. The invention further provides a preparation process of Pudilan mouth wash. The Pudilan extracts are added into the mouth wash, and the Pudilan mouth wash has the function of cleaning teeth, remarkably improves abilities of sterilizing, eliminating inflammation and resisting dental caries, and removes oral malodor.
Description
Technical field
The present invention relates to a kind of collutory is and in particular to a kind of blue collutory in Pu ground and its preparation technology.
Background technology
Collutory is a kind of relatively conventional oral-cavity cleaning products, has the advantages that using simple, easy to carry, thus gargles
Saliva is commercially popular.Collutory can solve many oral problem, such as periodontitis, dental caries, halitosiss, stomatitis
The oral problem such as disease.Traditional collutory contains more ethanol or is combined in reagent containing chemistry, or component is excessively single, or
DeGrain, does not have protective effect to tooth and oral cavity.
A kind of fresh fruit Herba Menthae collutory that Chinese patent application 201610544133.4 discloses, including following parts by weight
Component: water 95-98 part, glycerol 1-2.5 part, peg-40 castor oil hydrogenated 0.5-1.2 part, essence 3-5 part, saccharin sodium 0.01-
0.05 part, Mentholum 0.01-0.02 part, CHG 0.01-0.3 part, cetylpyridinium chloride 0.1-0.3 part, benzoic acid
Methyl ester 0.05-0.3 part, nipagin A 0.05-0.3 part, nipasol 0.05-0.3 part, hydroxy benzoic acid fourth
Ester 0.01-0.3 part, eugenol 0-0.005 part, limonene 0-0.005 part.The main component of the collutory of this patent application is
Some additives, thus it dispels halitosiss and antibacterial and anti-caries DeGrain.
Chinese patent application 201510372484.7 discloses a kind of natural Chinese prescription collutory, in mass ratio, comprising: Radix Glycyrrhizae
Extract: 0.2-5.0%；Folium Camelliae sinensis extract: 0.1-5.0%；Radix Scutellariae extract: 0.1-3.0%；Cortex Phellodendri extract: 0.1-
3.0%；Galla Chinensis extract: 0.1-5.0%；Flos Lonicerae extract: 0.1-5.0%；Ramulus Cinnamomi extract: 0.1-3.0%；Also wrap
Include menthyl lactate: 0.01-3.0%；Citric acid: 0.01-3.0%；Glycerol: 0.5-8.0%；Sorbitol: 0.5-8.0%, gathers
Sorbitol ester -20:0.1-1.0%.The collutory of this application has certain bacteriostasis, but which employs more Chinese medicine and carry
Take thing, thus can not use for a long time.
Chinese patent application 201510996016.7 discloses a kind of anti-swollen anti-inflammation gargle water, former by following mass fraction
Material is made: Flos Lonicerae 11-14 part, Herba Taraxaci 7-9 part, Herba Menthae 5-7 part, vitamin b12 10-14 part, Flos Carthami 11-13 part, Flos Chrysanthemi
8-9 part, scented tea 9-10 part, Radix Scutellariae 5-7 part, Fructus Forsythiae extracting solution 6-9 part, calcium bicarbonate two water salt 11-15 part, xylitol 6-8 part,
Sorbitol 9-11 part, Borneolum Syntheticum 11-14 part, water 30-35 part.A variety of Chinese medicine composition is contained, containing more in this patent application
Borneolum Syntheticum, belongs to lower toxicity material, thus is difficult life-time service.
Chinese patent application 201310380295.5 discloses a kind of deodorant mouth wash, it be by sodium citrate, perilla oil,
Eucalyptus oil, ethanol, calcium bicarbonate anhydrous salt, Pyrusussuriensiss methylol, xylitol and distilled water mixed preparing form, described each component
Weight portion is: sodium citrate: 1-2 part；Perilla oil: 1-2 part；Eucalyptus oil: 1-2 part；Ethanol: 10-20 part；Calcium bicarbonate is anhydrous
Salt: 1-2 part；Pyrusussuriensiss methylol: 1-2 part；Xylitol: 1-2 part；Distilled water: 80-100 part.The collutory of this patent application, can
To play certain effect removing antihalitosis, but the single effect because of its component, therefore, the single effect of collutory, to tooth
Do not have protection with oral cavity.
It is therefore desirable to have new mouthrinse product is to meet the demand of people.
Content of the invention
In order to overcome the deficiencies in the prior art, a kind of sterilization, antiinflammatory are provided, go the Pu ground indigo plant of removing abnormal flavor in oral cavity to gargle
Saliva and its preparation technology.
The technical scheme is that, the blue collutory in Pu ground, includings following components: Sorbitol, edible ethanol, glycerol, gather
Ethylene glycol -400, sodium citrate, peg- castor oil hydrogenated, Poloxamer 127, xylitol, the blue extract in Pu ground, Radix Scutellariae extract
Thing, sodium fluoride, cetylpyridinium chloride, Mint Essence, methyl hydroxybenzoate and purified water.
Further, described Pu ground indigo plant collutory, including the component of following percetage by weight:
Further, described Pu ground indigo plant extract is prepared by the component of following parts by weight:
500 parts of Herba Taraxaci,
Herba Corydalis Bungeanae 115-140 part,
Radix Isatidis 175-200 part.
Further, the preparation method of described Pu ground indigo plant extract, comprises the following steps:
(1) take Herba Taraxaci, Herba Corydalis Bungeanae and Radix Isatidis extracting in water secondary, filtration, merging filtrate；
(2) described filtrate is concentrated into relative density 1.10-1.20, plus ethanol makes alcohol content reach 65%, stands 40-50h, on
Clear liquid is concentrated into relative density 1.10-1.20, plus ethanol makes alcohol content reach 80%, stands 24-30h, and supernatant concentration is to relatively
Density 1.28-1.32 extractum；
(3) extractum 100g is taken to add 800-900g purified water, 48-55g sodium citrate to stir, heated and boiled 30-
45min, places cold preservation 60-80h in 0-4 DEG C of refrigerator after being cooled to room temperature, takes out extractum, filter, and filtrate is with being Pu blue to extract
Thing.
Further, described water extraction, first time plus 10 times amount water, soak 30-45min, extract 1-1.5h, add for second
8 times amount water, extract 1-1.5h.
Further, the blue collutory in Pu ground, including the component of following percetage by weight:
The preparation technology of the blue collutory in Pu ground, comprises the following steps:
(1) weigh Poloxamer 127, add purified water, stir to dissolving, be then heated to 55-65 DEG C, heat up to enter simultaneously
Row stirring, and add peg- castor oil hydrogenated, Sorbitol, glycerol, PEG-4000, sodium citrate, xylitol and sodium fluoride,
55-65 DEG C stir to dissolving after, start lower the temperature, treat that temperature is down to less than 40 DEG C, add Pu ground indigo plant extract, Radix Scutellariae extract and
Cetylpyridinium chloride, stirs to dissolving, obtains mixed solution；
(2) separately weigh Mint Essence, methyl hydroxybenzoate in beaker, add edible ethanol stirring and dissolving, be added to described mixing
In solution, after stirring, filter, filtrate obtains final product.
Further, before described step (2) is filtered, measure the ph value of solution, control ph value to be 5.5-7.5.
Blue for Pu ground extract is added in collutory the present invention, and provides the preparation method of the blue extract in Pu ground, Pu
In the blue extract of the blue effective interpolation scope in ground and Pu ground, the content of Herba Taraxaci, Herba Corydalis Bungeanae and Radix Isatidis, adds Radix Scutellariae simultaneously
Extract and sodium fluoride, control the content of each component in collutory, for active Chinese medicinal components, its content
Proportioning is the key factor of impact collutory performance.The collutory of the present invention has sterilization, antiinflammatory, dental caries ability and removal
Effect of halitosiss.The preparation technology of the collutory of the present invention passes through substep addO-on therapy, the process controlling in technical process
Temperature and regulation ph value etc., improve performance and effect of collutory further.
Specific embodiment
Embodiment 1
The blue collutory in Pu ground, including the component of following percetage by weight:
Wherein, blue the adopting of extract in Pu ground prepares with the following method, comprises the following steps:
(1) take 500g Herba Taraxaci, 125g Herba Corydalis Bungeanae and 188g Radix Isatidis extracting in water secondary, add 10 times amount water for the first time,
Soak 30min, extract 1h, second plus 8 times amount water, extract 1h, filtration, merging filtrate；
(2) described filtrate is concentrated into relative density 1.15, plus ethanol makes alcohol content reach 65%, stands 48h, supernatant concentration
To relative density 1.15, plus ethanol makes alcohol content reach 80%, stands 24h, supernatant concentration is to relative density 1.30 extractum；
(3) extractum 100g is taken to add 850g purified water, 50g sodium citrate to stir, heated and boiled 30min, it is cooled to
Place cold preservation 72h in 0-4 DEG C of refrigerator after room temperature, take out extractum, filter, filtrate is the blue extract in Pu ground.
According to the proportioning of the blue collutory in above-mentioned Pu ground, make to prepare as follows:
(1) weigh Poloxamer 127, add purified water, stir to dissolving, be then heated to 60 DEG C, heat up and carry out simultaneously
Stirring, and add peg- castor oil hydrogenated, Sorbitol, glycerol, PEG-4000, sodium citrate, xylitol and sodium fluoride, 60
DEG C stir to dissolving, start to lower the temperature, treat that temperature is down to less than 40 DEG C, add Pu ground indigo plant extract, Radix Scutellariae extract and western pyrrole
Oronain, stirs to dissolving, obtains mixed solution；
(2) separately weigh Mint Essence, methyl hydroxybenzoate in beaker, add edible ethanol stirring and dissolving, be added to described mixing
In solution, after stirring, measure ph value, control ph value to be 6.5, water filtration of then gargling, filtrate obtains final product.
Embodiment 2
The blue collutory in Pu ground, including the component of following percetage by weight:
Wherein, blue the adopting of extract in Pu ground prepares with the following method, comprises the following steps:
(1) take 500g Herba Taraxaci, 115g Herba Corydalis Bungeanae and 175g Radix Isatidis extracting in water secondary, add 10 times amount water for the first time,
Soak 40min, extract 1.2h, second plus 8 times amount water, extract 1.2h, filtration, merging filtrate；
(2) described filtrate is concentrated into relative density 1.10, plus ethanol makes alcohol content reach 65%, stands 40h, supernatant concentration
To relative density 1.10, plus ethanol makes alcohol content reach 80%, stands 28h, supernatant concentration is to relative density 1.28 extractum；
(3) extractum 100g is taken to add 800g purified water, 48g sodium citrate to stir, heated and boiled 40min, it is cooled to
Place cold preservation 60h in 0-4 DEG C of refrigerator after room temperature, take out extractum, filter, filtrate is the blue extract in Pu ground.
According to the proportioning of the blue collutory in above-mentioned Pu ground, make to prepare as follows:
(1) weigh Poloxamer 127, add purified water, stir to dissolving, be then heated to 55 DEG C, heat up and carry out simultaneously
Stirring, and add peg- castor oil hydrogenated, Sorbitol, glycerol, PEG-4000, sodium citrate, xylitol and sodium fluoride, 55
DEG C stir to dissolving, start to lower the temperature, treat that temperature is down to less than 40 DEG C, add Pu ground indigo plant extract, Radix Scutellariae extract and western pyrrole
Oronain, stirs to dissolving, obtains mixed solution；
(2) separately weigh Mint Essence, methyl hydroxybenzoate in beaker, add edible ethanol stirring and dissolving, be added to described mixing
In solution, after stirring, measure ph value, control ph value to be 5.5, water filtration of then gargling, filtrate obtains final product.
Embodiment 3
The blue collutory in Pu ground, including the component of following percetage by weight:
Wherein, blue the adopting of extract in Pu ground prepares with the following method, comprises the following steps:
(1) take 500g Herba Taraxaci, 140g Herba Corydalis Bungeanae and 200g Radix Isatidis extracting in water secondary, add 10 times amount water for the first time,
Soak 45min, extract 1.5h, second plus 8 times amount water, extract 1.5h, filtration, merging filtrate；
(2) described filtrate is concentrated into relative density 1.20, plus ethanol makes alcohol content reach 65%, stands 50h, supernatant concentration
To relative density 1.20, plus ethanol makes alcohol content reach 80%, stands 30h, supernatant concentration is to relative density 1.32 extractum；
(3) extractum 100g is taken to add 900g purified water, 55g sodium citrate to stir, heated and boiled 45min, it is cooled to
Place cold preservation 80h in 0-4 DEG C of refrigerator after room temperature, take out extractum, filter, filtrate is the blue extract in Pu ground.
According to the proportioning of the blue collutory in above-mentioned Pu ground, make to prepare as follows:
(1) weigh Poloxamer 127, add purified water, stir to dissolving, be then heated to 65 DEG C, heat up and carry out simultaneously
Stirring, and add peg- castor oil hydrogenated, Sorbitol, glycerol, PEG-4000, sodium citrate, xylitol and sodium fluoride, 65
DEG C stir to dissolving, start to lower the temperature, treat that temperature is down to less than 40 DEG C, add Pu ground indigo plant extract, Radix Scutellariae extract and western pyrrole
Oronain, stirs to dissolving, obtains mixed solution；
(2) separately weigh Mint Essence, methyl hydroxybenzoate in beaker, add edible ethanol stirring and dissolving, be added to described mixing
In solution, after stirring, measure ph value, control ph value to be 7.5, water filtration of then gargling, filtrate obtains final product.
Embodiment 4
The blue collutory in Pu ground, including the component of following percetage by weight:
Wherein, blue the adopting of extract in Pu ground prepares with the following method, comprises the following steps:
(1) take 500g Herba Taraxaci, 115g Herba Corydalis Bungeanae and 175g Radix Isatidis extracting in water secondary, add 10 times amount water for the first time,
Soak 40min, extract 1.2h, second plus 8 times amount water, extract 1.2h, filtration, merging filtrate；
(2) described filtrate is concentrated into relative density 1.10, plus ethanol makes alcohol content reach 65%, stands 40h, supernatant concentration
To relative density 1.10, plus ethanol makes alcohol content reach 80%, stands 28h, supernatant concentration is to relative density 1.28 extractum；
(3) extractum 100g is taken to add 800g purified water, 48g sodium citrate to stir, heated and boiled 40min, it is cooled to
Place cold preservation 60h in 0-4 DEG C of refrigerator after room temperature, take out extractum, filter, filtrate is the blue extract in Pu ground.
According to the proportioning of the blue collutory in above-mentioned Pu ground, make to prepare as follows:
(1) weigh Poloxamer 127, add purified water, stir to dissolving, be then heated to 55 DEG C, heat up and carry out simultaneously
Stirring, and add peg- castor oil hydrogenated, Sorbitol, glycerol, PEG-4000, sodium citrate, xylitol and sodium fluoride, 55
DEG C stir to dissolving, start to lower the temperature, treat that temperature is down to less than 40 DEG C, add Pu ground indigo plant extract, Radix Scutellariae extract and western pyrrole
Oronain, stirs to dissolving, obtains mixed solution；
(2) separately weigh Mint Essence, methyl hydroxybenzoate in beaker, add edible ethanol stirring and dissolving, be added to described mixing
In solution, after stirring, measure ph value, control ph value to be 5.5, water filtration of then gargling, filtrate obtains final product.
Comparative example 1
The blue collutory in Pu ground, including the component of following percetage by weight:
Wherein, blue the adopting of extract in Pu ground prepares with the following method, comprises the following steps:
(1) take 500g Herba Taraxaci, 125g Herba Corydalis Bungeanae and 188g Radix Isatidis extracting in water secondary, add 10 times amount water for the first time,
Soak 30min, extract 1h, second plus 8 times amount water, extract 1h, filtration, merging filtrate；
(2) described filtrate is concentrated into relative density 1.15, plus ethanol makes alcohol content reach 65%, stands 48h, supernatant concentration
To relative density 1.15, plus ethanol makes alcohol content reach 80%, stands 24h, supernatant concentration is to relative density 1.30 extractum；
(3) extractum 100g is taken to add 850g purified water, 50g sodium citrate to stir, heated and boiled 30min, it is cooled to
Place cold preservation 72h in 0-4 DEG C of refrigerator after room temperature, take out extractum, filter, filtrate is the blue extract in Pu ground.
According to the proportioning of the blue collutory in above-mentioned Pu ground, make to prepare as follows:
(1) weigh Poloxamer 127, add purified water, stir to dissolving, be then heated to 60 DEG C, heat up and carry out simultaneously
Stirring, and add peg- castor oil hydrogenated, Sorbitol, glycerol, PEG-4000, sodium citrate, xylitol and sodium fluoride, 60
DEG C stir to dissolving, start to lower the temperature, treat that temperature is down to less than 40 DEG C, add Pu ground indigo plant extract, Radix Scutellariae extract and western pyrrole
Oronain, stirs to dissolving, obtains mixed solution；
(2) separately weigh Mint Essence, methyl hydroxybenzoate in beaker, add edible ethanol stirring and dissolving, be added to described mixing
In solution, after stirring, measure ph value, control ph value to be 6.5, water filtration of then gargling, filtrate obtains final product.
Comparative example 2
The blue collutory in Pu ground, including the component of following percetage by weight:
Wherein, blue the adopting of extract in Pu ground prepares with the following method, comprises the following steps:
(1) take 500g Herba Taraxaci, 100g Herba Corydalis Bungeanae and 213g Radix Isatidis extracting in water secondary, add 10 times amount water for the first time,
Soak 30min, extract 1h, second plus 8 times amount water, extract 1h, filtration, merging filtrate；
(2) described filtrate is concentrated into relative density 1.15, plus ethanol makes alcohol content reach 65%, stands 48h, supernatant concentration
To relative density 1.15, plus ethanol makes alcohol content reach 80%, stands 24h, supernatant concentration is to relative density 1.30 extractum；
(3) extractum 100g is taken to add 850g purified water, 50g sodium citrate to stir, heated and boiled 30min, it is cooled to
Place cold preservation 72h in 0-4 DEG C of refrigerator after room temperature, take out extractum, filter, filtrate is the blue extract in Pu ground.
According to the proportioning of the blue collutory in above-mentioned Pu ground, make to prepare as follows:
(1) weigh Poloxamer 127, add purified water, stir to dissolving, be then heated to 60 DEG C, heat up and carry out simultaneously
Stirring, and add peg- castor oil hydrogenated, Sorbitol, glycerol, PEG-4000, sodium citrate, xylitol and sodium fluoride, 60
DEG C stir to dissolving, start to lower the temperature, treat that temperature is down to less than 40 DEG C, add Pu ground indigo plant extract, Radix Scutellariae extract and western pyrrole
Oronain, stirs to dissolving, obtains mixed solution；
(2) separately weigh Mint Essence, methyl hydroxybenzoate in beaker, add edible ethanol stirring and dissolving, be added to described mixing
In solution, after stirring, measure ph value, control ph value to be 6.5, water filtration of then gargling, filtrate obtains final product.
1st, performance test is carried out to the collutory prepared by embodiment of the present invention 1-3 and comparative example 1-2.Test result is listed in
In table 1.
Table 1
As it can be seen from table 1 halitosis and oral ulcer are improved or cured to the water energy of gargling prepared by the present invention effectively.
Blue collutory in Pu the ground above embodiment of the present invention being provided and preparation method thereof, is described in detail, this
Apply specific case in literary composition the principle of the present invention and embodiment are set forth, the explanation of above example is only intended to
Help understands the method for the present invention and its core concept；Simultaneously for one of ordinary skill in the art, according to the think of of the present invention
Think, all will change in specific embodiments and applications, in sum, it is right that this specification content should not be construed as
The restriction of the present invention.
Claims (8)
1. the blue collutory in Pu ground is it is characterised in that include following components: Sorbitol, edible ethanol, glycerol, PEG-4000,
Sodium citrate, peg- castor oil hydrogenated, Poloxamer 127, xylitol, the blue extract in Pu ground, Radix Scutellariae extract, sodium fluoride, west
Pyrrole oronain, Mint Essence, methyl hydroxybenzoate and purified water.
2. Pu ground according to claim 1 indigo plant collutory is it is characterised in that described collutory includes following percetage by weight
Component:
3. the blue collutory in Pu ground according to any one of claim 1-2 it is characterised in that the blue extract in described Pu ground by with
The component of lower parts by weight prepares:
500 parts of Herba Taraxaci,
Herba Corydalis Bungeanae 115-140 part,
Radix Isatidis 175-200 part.
4. the blue collutory in Pu according to claim 3 ground is it is characterised in that the preparation method of the blue extract in described Pu ground,
Comprise the following steps:
(1) take Herba Taraxaci, Herba Corydalis Bungeanae and Radix Isatidis extracting in water secondary, filtration, merging filtrate；
(2) described filtrate is concentrated into relative density 1.10-1.20, plus ethanol makes alcohol content reach 65%, stands 40-50h, supernatant
It is concentrated into relative density 1.10-1.20, plus ethanol makes alcohol content reach 80%, stands 24-30h, supernatant concentration is to relative density
1.28-1.32 extractum；
(3) extractum 100g is taken to add 800-900g purified water, 48-55g sodium citrate to stir, heated and boiled 30-45min,
Place cold preservation 60-80h in 0-4 DEG C of refrigerator after being cooled to room temperature, take out extractum, filter, filtrate is the blue extract in Pu ground.
5. the blue collutory in Pu ground according to claim 4, it is characterised in that described water extraction, adds 10 times amount water, leaching for the first time
Bubble 30-45min, extracts 1-1.5h, second plus 8 times amount water, extracts 1-1.5h.
6. the blue collutory in Pu according to claim 1 ground is it is characterised in that the blue collutory in Pu ground, including following weight hundred
The component of fraction:
7. the preparation technology of the blue collutory in Pu ground is it is characterised in that comprise the following steps:
(1) weigh Poloxamer 127, add purified water, stir to dissolving, be then heated to 55-65 DEG C, heat up and stirred simultaneously
Mix, and add peg- castor oil hydrogenated, Sorbitol, glycerol, PEG-4000, sodium citrate, xylitol and sodium fluoride, 55-
65 DEG C are stirred to dissolving, start to lower the temperature, treat that temperature is down to less than 40 DEG C, add the blue extract in Pu ground, Radix Scutellariae extract and west
Pyrrole oronain, stirs to dissolving, obtains mixed solution；
(2) separately weigh Mint Essence, methyl hydroxybenzoate in beaker, add edible ethanol stirring and dissolving, be added to described mixed solution
In, after stirring, filter, filtrate obtains final product.
8. preparation technology according to claim 7 is it is characterised in that before described step (2) filtration, measure the ph of solution
Value, controls ph value to be 5.5-7.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610946205.8A CN106361642B (en) | 2016-10-26 | 2016-10-26 | Pudilan mouthwash and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610946205.8A CN106361642B (en) | 2016-10-26 | 2016-10-26 | Pudilan mouthwash and preparation process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106361642A true CN106361642A (en) | 2017-02-01 |
| CN106361642B CN106361642B (en) | 2019-12-10 |
Family
ID=57893096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610946205.8A Active CN106361642B (en) | 2016-10-26 | 2016-10-26 | Pudilan mouthwash and preparation process thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106361642B (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729650A (en) * | 2017-03-03 | 2017-05-31 | 江苏所罗门兄弟医学科技有限公司 | A kind of oral cavity gargle for tumor patient |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN107693442A (en) * | 2017-09-14 | 2018-02-16 | 南通荣成医药化工有限公司 | A kind of efficient sterilizing mouthwash |
| CN108078871A (en) * | 2018-02-06 | 2018-05-29 | 三椒口腔健康股份有限公司 | A kind of mouthwash of the rare saponin(e containing Radix Notoginseng and preparation method thereof |
| CN108272862A (en) * | 2018-03-07 | 2018-07-13 | 济川药业集团有限公司 | A kind of Pudilan oral spray and preparation method thereof |
| CN108379139A (en) * | 2018-03-07 | 2018-08-10 | 济川药业集团有限公司 | A kind of toothpaste and its preparation method and application of anti-treating dental ulcer |
| CN109045157A (en) * | 2018-10-10 | 2018-12-21 | 广东心宝药业科技有限公司 | A kind of bactericidal composition of the extract containing Pudilan, mouthwash and preparation method thereof |
| CN110179722A (en) * | 2019-07-09 | 2019-08-30 | 许富明 | A kind of gargle and preparation method thereof with bacteria resistance function |
| CN111603418A (en) * | 2020-04-23 | 2020-09-01 | 广州宏康医药科技有限公司 | Oral care product capable of lasting freshness and bacteriostasis and preparation method thereof |
| CN113712863A (en) * | 2021-08-27 | 2021-11-30 | 广东南方洁灵科技实业有限公司 | Mild and non-irritant oral mouthwash and preparation method thereof |
| CN115400055A (en) * | 2022-09-06 | 2022-11-29 | 北京化工大学 | Multifunctional mouthwash and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943633A (en) * | 2005-10-09 | 2007-04-11 | 董斌 | Pudilan antiphlogistic granules and its Pudilan antiphlogistic granules prepared by said method |
| CN103070931A (en) * | 2013-02-06 | 2013-05-01 | 朱柏丞 | Traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions and preparations and quality control method thereof |
| CN103989599A (en) * | 2014-05-13 | 2014-08-20 | 济川药业集团有限公司 | Chinese herbal medicine toothpaste capable of diminishing inflammation and stopping bleeding |
-
2016
- 2016-10-26 CN CN201610946205.8A patent/CN106361642B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1943633A (en) * | 2005-10-09 | 2007-04-11 | 董斌 | Pudilan antiphlogistic granules and its Pudilan antiphlogistic granules prepared by said method |
| CN103070931A (en) * | 2013-02-06 | 2013-05-01 | 朱柏丞 | Traditional Chinese medicine extract with heat-clearing, detoxifying, antibacterial and anti-inflammatory functions and preparations and quality control method thereof |
| CN103989599A (en) * | 2014-05-13 | 2014-08-20 | 济川药业集团有限公司 | Chinese herbal medicine toothpaste capable of diminishing inflammation and stopping bleeding |
Non-Patent Citations (2)
| Title |
|---|
| 佚名: "美乐家浓缩洁齿漱口水-鲜薄荷", 《HTTP://WWW.COSDNA.COM/CHS/COSMETIC_C54C120277.HTML》 * |
| 刘迪昕等: "蒲地蓝口服液辅助治疗牙龈炎的临床研究", 《中华医院感染学杂志》 * |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729650A (en) * | 2017-03-03 | 2017-05-31 | 江苏所罗门兄弟医学科技有限公司 | A kind of oral cavity gargle for tumor patient |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN107693442A (en) * | 2017-09-14 | 2018-02-16 | 南通荣成医药化工有限公司 | A kind of efficient sterilizing mouthwash |
| CN108078871A (en) * | 2018-02-06 | 2018-05-29 | 三椒口腔健康股份有限公司 | A kind of mouthwash of the rare saponin(e containing Radix Notoginseng and preparation method thereof |
| CN108078871B (en) * | 2018-02-06 | 2019-04-12 | 三椒口腔健康股份有限公司 | A kind of mouthwash of the rare saponin(e containing Radix Notoginseng and preparation method thereof |
| CN108379139B (en) * | 2018-03-07 | 2020-12-08 | 济川药业集团有限公司 | Toothpaste for preventing and treating dental ulcer and preparation method and application thereof |
| CN108272862A (en) * | 2018-03-07 | 2018-07-13 | 济川药业集团有限公司 | A kind of Pudilan oral spray and preparation method thereof |
| CN108379139A (en) * | 2018-03-07 | 2018-08-10 | 济川药业集团有限公司 | A kind of toothpaste and its preparation method and application of anti-treating dental ulcer |
| CN108272862B (en) * | 2018-03-07 | 2021-01-05 | 济川药业集团有限公司 | Pudilan oral spray and preparation method thereof |
| CN109045157A (en) * | 2018-10-10 | 2018-12-21 | 广东心宝药业科技有限公司 | A kind of bactericidal composition of the extract containing Pudilan, mouthwash and preparation method thereof |
| CN110179722A (en) * | 2019-07-09 | 2019-08-30 | 许富明 | A kind of gargle and preparation method thereof with bacteria resistance function |
| CN111603418A (en) * | 2020-04-23 | 2020-09-01 | 广州宏康医药科技有限公司 | Oral care product capable of lasting freshness and bacteriostasis and preparation method thereof |
| CN113712863A (en) * | 2021-08-27 | 2021-11-30 | 广东南方洁灵科技实业有限公司 | Mild and non-irritant oral mouthwash and preparation method thereof |
| CN115400055A (en) * | 2022-09-06 | 2022-11-29 | 北京化工大学 | Multifunctional mouthwash and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106361642B (en) | 2019-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106361642A (en) | Pudilan mouth wash and preparation process thereof | |
| CN104887581B (en) | A kind of oral care composition and preparation method thereof | |
| CN104207982B (en) | Prevent Chinese medicine composition and the oral care product containing it that oral cavity is got angry | |
| CN101518507B (en) | Tibetan incense cosmetic daily chemical product and preparation method thereof | |
| CN101199467B (en) | Whitening and skin-protecting compound essential oils | |
| CN103655329A (en) | Cleaning astringent lotion | |
| KR20190086317A (en) | A composition for prevention or improvement of atopic dermatitis containing a herbal complex extract | |
| CN104382786A (en) | Hair loss prevention hair-blacking agent and preparation method thereof | |
| CN106361669A (en) | Body lotion | |
| CN110604706A (en) | Hair loss preventing and caring plant composition, preparation method and application | |
| CN105769633A (en) | Plant anti-allergy skincare essence and preparation method thereof | |
| CN104161718A (en) | Loofah skin moisturizer and preparation method thereof | |
| KR20100112720A (en) | Shampoo composition containing oriental medicine and manufacturing method thereof | |
| CN105062726A (en) | Medicated soap for conditioning skin and weakening melanin | |
| CN106727014A (en) | A kind of compound of wild rattan mother-in-law tea extraction and its application | |
| CN103816070A (en) | Hair growing shampoo containing ginger and cacumen biotae | |
| CN106580834A (en) | Infant hip nursing essence | |
| CN106491473A (en) | A kind of alimentary water with crease-resistant effect | |
| KR20110062214A (en) | Composition for improving atopic dermatitis and the manufacturing method thereof | |
| CN108210435A (en) | It is a kind of to sterilize the acne green spot eliminating skin care suncream and preparation method thereof that disappears | |
| CN103284939A (en) | Preparation method for white peony root freckle removing facial mask | |
| CN103462852B (en) | A kind of anti-pox astringent and preparation method thereof | |
| CN106491430A (en) | A kind of Flos Lonicerae compound recipe herbaceous toothpaste and preparation method thereof | |
| CN102671093A (en) | Sober-up tea and preparation thereof | |
| CN102949311B (en) | Additive-free children bath liquid and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211222 Address after: 225441 6f-1, No. 318, Yongfeng South Road, Huangqiao Town, Taixing City, Taizhou City, Jiangsu Province Patentee after: Jiangsu Pudilan Daily Chemical Co.,Ltd. Address before: 225400 baotawan Jichuan Pharmaceutical Group Co., Ltd., Daqing West Road, Taixing City, Taizhou City, Jiangsu Province Patentee before: JUMPCAN PHARMACEUTICAL GROUP Co.,Ltd. |