CN106361642B

CN106361642B - Pudilan mouthwash and preparation process thereof

Info

Publication number: CN106361642B
Application number: CN201610946205.8A
Authority: CN
Inventors: 曹龙祥; 董自波; 田刚; 杨北平; 邵建国; 李萍
Original assignee: JICHUAN PHARMACEUTICAL GROUP Co Ltd
Current assignee: Jiangsu Pudilan Daily Chemical Co.,Ltd.
Priority date: 2016-10-26
Filing date: 2016-10-26
Publication date: 2019-12-10
Anticipated expiration: 2036-10-26
Also published as: CN106361642A

Abstract

The invention relates to a mouthwash, and particularly discloses a Pudilan mouthwash, which comprises the following components: sorbitol, edible ethanol, glycerol, polyethylene glycol-400, sodium citrate, PEG-hydrogenated castor oil, poloxamer 127, xylitol, Pudilan extract, Scutellaria baicalensis extract, sodium fluoride, cetylpyridinium chloride, mint essence, methylparaben and purified water. The invention also provides a preparation process of the Pudilan mouthwash. The invention adds the Pudilan blue extract into mouthwash and provides a preparation method of the Pudilan blue extract. The mouthwash of the invention not only has the function of cleaning teeth, but also obviously improves the sterilization, anti-inflammation and anti-dental caries capability of the mouthwash, and the efficacy of removing the peculiar smell of the oral cavity.

Description

pudilan mouthwash and preparation process thereof

Technical Field

the invention relates to mouthwash, and in particular relates to dandelion mouthwash and a preparation process thereof.

Background

The mouthwash is a common oral cleaning product and has the advantages of simple use, convenient carrying and the like, so the mouthwash is very popular in the market. The mouthwash can solve a plurality of oral problems, such as periodontitis, decayed teeth, oral odor, oral inflammation and the like. The traditional mouthwash contains more alcohol or chemical synthetic agents, or has too single component or unobvious effect, and cannot protect teeth and oral cavity.

chinese patent application 201610544133.4 discloses a fresh fruit mint mouthwash, which comprises the following components in parts by weight: 95-98 parts of water, 1-2.5 parts of glycerol, 0.5-1.2 parts of PEG-40 hydrogenated castor oil, 3-5 parts of essence, 0.01-0.05 part of saccharin sodium, 0.01-0.02 part of menthol, 0.01-0.3 part of chlorhexidine digluconate, 0.1-0.3 part of cetylpyridinium chloride, 0.05-0.3 part of methyl benzoate, 0.05-0.3 part of ethyl hydroxybenzoate, 0.05-0.3 part of propyl hydroxybenzoate, 0.01-0.3 part of butyl hydroxybenzoate, 0-0.005 part of eugenol and 0-0.005 part of lemon oil. The main components of the mouthwash applied by the patent are additives, so that the effects of removing oral peculiar smell, inhibiting bacteria and preventing decayed teeth are not obvious.

chinese patent application 201510372484.7 discloses a natural Chinese prescription mouthwash, which comprises the following components in percentage by mass: and (3) liquorice extract: 0.2 to 5.0 percent; tea extract: 0.1 to 5.0 percent; and (3) extracting scutellaria baicalensis: 0.1 to 3.0 percent; and (3) golden cypress extract: 0.1 to 3.0 percent; gallnut extract: 0.1 to 5.0 percent; and (3) honeysuckle extract: 0.1 to 5.0 percent; cassia twig extract: 0.1 to 3.0 percent; also included are menthyl lactate: 0.01 to 3.0 percent; citric acid: 0.01 to 3.0 percent; glycerol: 0.5 to 8.0 percent; sorbitol: 0.5-8.0%, polysorbate-20: 0.1 to 1.0 percent. The mouthwash has a certain bacteriostatic action, but the mouthwash is not used for a long time due to the adoption of more traditional Chinese medicine extracts.

chinese patent application 201510996016.7 discloses an anti-swelling and anti-inflammation mouthwash, which is prepared from the following raw materials in parts by weight: 11-14 parts of honeysuckle, 7-9 parts of dandelion, 5-7 parts of mint, 1210-14 parts of vitamin B, 11-13 parts of safflower, 8-9 parts of chrysanthemum, 9-10 parts of scented tea, 5-7 parts of scutellaria baicalensis, 6-9 parts of fructus forsythiae extract, 11-15 parts of calcium bicarbonate dihydrate salt, 6-8 parts of xylitol, 9-11 parts of sorbitol, 11-14 parts of borneol and 30-35 parts of water. The patent application contains various traditional Chinese medicine components, contains more borneol, belongs to low-toxicity substances and is not easy to use for a long time.

chinese patent application 201310380295.5 discloses a deodorant mouthwash, which is prepared by mixing sodium citrate, perilla oil, eucalyptus oil, ethanol, anhydrous salt of calcium bicarbonate, sorbitol, xylitol and distilled water, wherein the components are as follows by weight: sodium citrate: 1-2 parts; perilla oil: 1-2 parts; eucalyptus oil: 1-2 parts; ethanol: 10-20 parts; anhydrous calcium bicarbonate salt: 1-2 parts; sorbitol methyl alcohol: 1-2 parts; xylitol: 1-2 parts; distilled water: 80-100 parts. The mouthwash applied by the patent can play a certain effect of removing halitosis, but because the effect of the components is single, the mouthwash has a single effect and cannot protect teeth and oral cavities.

therefore, there is a need for new mouthwash products to meet the needs of people.

disclosure of Invention

in order to overcome the defects in the prior art, the Pudilan mouthwash capable of sterilizing, diminishing inflammation and removing oral peculiar smell and the preparation process thereof are provided.

The technical scheme of the invention is that the Pudilan mouthwash comprises the following components: sorbitol, edible ethanol, glycerol, polyethylene glycol-400, sodium citrate, PEG-hydrogenated castor oil, poloxamer 127, xylitol, Pudilan extract, Scutellaria baicalensis extract, sodium fluoride, cetylpyridinium chloride, mint essence, methylparaben and purified water.

Further, the Pudilan mouthwash comprises the following components in percentage by weight:

Further, the Pudilan extract is prepared from the following components in parts by weight:

500 parts of dandelion,

115 portions and 140 portions of bunge corydalis herb,

175 portions of isatis root and 200 portions of fructus isatidis.

Further, the preparation method of the Pudilan extract comprises the following steps:

(1) Extracting herba Taraxaci, herba corydalis Bungeanae and radix Isatidis with water twice, filtering, and mixing filtrates;

(2) concentrating the filtrate to relative density of 1.10-1.20, adding ethanol to make ethanol content reach 65%, standing for 40-50 hr, concentrating the supernatant to relative density of 1.10-1.20, adding ethanol to make ethanol content reach 80%, standing for 24-30 hr, concentrating the supernatant to relative density of 1.28-1.32 to obtain extract;

(3) Adding 800-900g purified water and 48-55g sodium citrate into 100g of the extract, uniformly stirring, heating and boiling for 30-45min, cooling to room temperature, placing in a refrigerator at 0-4 ℃, refrigerating for 60-80h, taking out the extract, and filtering to obtain filtrate, namely the Pudilan extract.

further, the water extraction is carried out by adding 10 times of water for the first time, soaking for 30-45min, extracting for 1-1.5h, and adding 8 times of water for the second time, extracting for 1-1.5 h.

the preparation process of the Pudilan mouthwash comprises the following steps:

(1) Weighing poloxamer 127, adding purified water, stirring to dissolve, heating to 55-65 ℃, heating while stirring, adding PEG-hydrogenated castor oil, sorbitol, glycerol, polyethylene glycol-400, sodium citrate, xylitol and sodium fluoride, stirring at 55-65 ℃ to dissolve, cooling, adding Pudilan extract, Scutellaria baicalensis extract and cetylpyridinium chloride when the temperature is reduced to below 40 ℃, and stirring to dissolve to obtain a mixed solution;

(2) weighing herba Menthae essence and methyl hydroxybenzoate, adding edible ethanol, stirring for dissolving, adding into the mixed solution, stirring, and filtering to obtain filtrate.

further, before the filtration in the step (2), the pH value of the solution is measured, and the pH value is controlled to be 5.5-7.5.

The invention adds Pudilan blue extract into mouthwash, and provides a preparation method of the Pudilan blue extract, the effective adding range of the Pudilan blue and the contents of dandelion, corydalis bungeana and isatis root in the Pudilan blue extract are added, meanwhile, the scutellaria extract and sodium fluoride are added, the content of each component in the mouthwash is controlled, and particularly for active traditional Chinese medicine components, the content ratio is an important factor influencing the mouthwash performance. The mouthwash of the invention has the functions of sterilization, anti-inflammation, anti-caries and removing oral peculiar smell. The preparation process of the mouthwash further improves the performance and efficacy of the mouthwash by adding components step by step, controlling the treatment temperature in the process, adjusting the pH value and the like.

Detailed Description

Example 1

The Pudilan mouthwash comprises the following components in percentage by weight:

the Pudilan extract is prepared by the following method, and comprises the following steps:

(1) Extracting 500g herba Taraxaci, 125g herba corydalis Bungeanae and 188g radix Isatidis with water twice, adding 10 times of water for the first time, soaking for 30min, extracting for 1 hr, adding 8 times of water for the second time, extracting for 1 hr, filtering, and mixing filtrates;

(2) concentrating the filtrate to relative density of 1.15, adding ethanol to make ethanol content reach 65%, standing for 48h, concentrating the supernatant to relative density of 1.15, adding ethanol to make ethanol content reach 80%, standing for 24h, concentrating the supernatant to relative density of 1.30 to obtain extract;

(3) Adding 850g of purified water and 50g of sodium citrate into 100g of the extract, uniformly stirring, heating and boiling for 30min, cooling to room temperature, placing in a refrigerator at 0-4 ℃, refrigerating for 72h, taking out the extract, and filtering to obtain filtrate, namely the Pudilan extract.

The Pudilan mouthwash is prepared according to the proportion of the Pudilan mouthwash:

(1) weighing poloxamer 127, adding purified water, stirring to dissolve, heating to 60 ℃, heating while stirring, adding PEG-hydrogenated castor oil, sorbitol, glycerol, polyethylene glycol-400, sodium citrate, xylitol and sodium fluoride, stirring at 60 ℃ to dissolve, cooling to below 40 ℃, adding Pudilan extract, Scutellaria baicalensis extract and cetylpyridinium chloride, and stirring to dissolve to obtain a mixed solution;

(2) weighing herba Menthae essence and methyl hydroxybenzoate, adding edible ethanol, stirring for dissolving, adding into the mixed solution, stirring, measuring pH, controlling pH to 6.5, filtering the collutory, and collecting filtrate.

example 2

(1) extracting 500g herba Taraxaci, 115g herba corydalis Bungeanae and 175g radix Isatidis with water twice, adding 10 times of water for the first time, soaking for 40min, extracting for 1.2 hr, adding 8 times of water for the second time, extracting for 1.2 hr, filtering, and mixing filtrates;

(2) concentrating the filtrate to relative density of 1.10, adding ethanol to make ethanol content reach 65%, standing for 40h, concentrating the supernatant to relative density of 1.10, adding ethanol to make ethanol content reach 80%, standing for 28h, concentrating the supernatant to relative density of 1.28 to obtain extract;

(3) Adding 800g of purified water and 48g of sodium citrate into 100g of the extract, uniformly stirring, heating and boiling for 40min, cooling to room temperature, placing in a refrigerator at 0-4 ℃, refrigerating for 60h, taking out the extract, and filtering to obtain filtrate, namely the Pudilan extract.

(1) Weighing poloxamer 127, adding purified water, stirring to dissolve, heating to 55 ℃, heating while stirring, adding PEG-hydrogenated castor oil, sorbitol, glycerol, polyethylene glycol-400, sodium citrate, xylitol and sodium fluoride, stirring at 55 ℃, cooling after stirring to dissolve, cooling to below 40 ℃, adding Pudilan extract, Scutellaria baicalensis extract and cetylpyridinium chloride, and stirring to dissolve to obtain a mixed solution;

(2) weighing herba Menthae essence and methyl hydroxybenzoate, adding edible ethanol, stirring for dissolving, adding into the mixed solution, stirring, measuring pH, controlling pH to 5.5, filtering the collutory, and collecting filtrate.

Example 3

(1) Extracting 500g herba Taraxaci, 140g herba corydalis Bungeanae and 200g radix Isatidis with water twice, adding 10 times of water for the first time, soaking for 45min, extracting for 1.5 hr, adding 8 times of water for the second time, extracting for 1.5 hr, filtering, and mixing filtrates;

(2) Concentrating the filtrate to relative density of 1.20, adding ethanol to make ethanol content reach 65%, standing for 50h, concentrating the supernatant to relative density of 1.20, adding ethanol to make ethanol content reach 80%, standing for 30h, concentrating the supernatant to relative density of 1.32 to obtain extract;

(3) Adding 900g of purified water and 55g of sodium citrate into 100g of the extract, uniformly stirring, heating and boiling for 45min, cooling to room temperature, placing in a refrigerator at 0-4 ℃ for refrigeration for 80h, taking out the extract, and filtering to obtain filtrate, namely the Pudilan extract.

(1) Weighing poloxamer 127, adding purified water, stirring to dissolve, heating to 65 ℃, heating while stirring, adding PEG-hydrogenated castor oil, sorbitol, glycerol, polyethylene glycol-400, sodium citrate, xylitol and sodium fluoride, stirring at 65 ℃ to dissolve, cooling to below 40 ℃, adding Pudilan extract, Scutellaria baicalensis extract and cetylpyridinium chloride, and stirring to dissolve to obtain a mixed solution;

(2) Weighing herba Menthae essence and methyl hydroxybenzoate, adding edible ethanol, stirring for dissolving, adding into the mixed solution, stirring, measuring pH, controlling pH to 7.5, filtering the collutory, and collecting filtrate.

Example 4

comparative example 1

Comparative example 2

(1) extracting 500g herba Taraxaci, 100g herba corydalis Bungeanae and 213g radix Isatidis with water twice, adding 10 times of water for the first time, soaking for 30min, extracting for 1 hr, adding 8 times of water for the second time, extracting for 1 hr, filtering, and mixing filtrates;

1. The mouthwashes prepared according to examples 1 to 3 of the present invention and comparative examples 1 to 2 were subjected to a performance test. The test results are listed in table 1.

TABLE 1

As can be seen from Table 1, the mouthwash prepared by the invention can effectively improve or cure halitosis and canker sores.

the pudendum blue mouthwash and the preparation method thereof provided by the embodiments of the invention are described in detail, the principles and the embodiments of the invention are explained by applying specific examples, and the description of the embodiments is only used for helping to understand the method and the core idea of the invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.

Claims

1. The Pudilan mouthwash is prepared from the following components in percentage by weight:

The Pudilan extract is prepared from the following components in parts by weight: 500 parts of dandelion, 115 parts of bunge corydalis herb and 140 parts of isatis root and 200 parts of isatis root;

The preparation process comprises the following steps: (1) weighing poloxamer 127, adding purified water, stirring to dissolve, heating to 55-65 ℃, heating while stirring, adding PEG-hydrogenated castor oil, sorbitol, glycerol, polyethylene glycol-400, sodium citrate, xylitol and sodium fluoride, stirring at 55-65 ℃ to dissolve, cooling, adding Pudilan extract, Scutellaria baicalensis extract and cetylpyridinium chloride when the temperature is reduced to below 40 ℃, and stirring to dissolve to obtain a mixed solution;

(2) Weighing herba Menthae essence and methyl hydroxybenzoate, adding edible ethanol, stirring for dissolving, adding into the mixed solution, stirring, and filtering to obtain filtrate;

before the filtration in the step (2), measuring the pH value of the solution, and controlling the pH value to be 5.5-7.5;

The preparation method of the Pudilan extract comprises the following steps:

2. The Pudilan mouthwash according to claim 1, wherein the Pudilan mouthwash is extracted by water, 10 times of water is added for the first time, the Pudilan mouthwash is soaked for 30-45min and extracted for 1-1.5h, and 8 times of water is added for the second time, and the extraction time is 1-1.5 h.

3. the Pudilan mouthwash according to claim 1, wherein the Pudilan mouthwash comprises the following components in percentage by weight:

4. a process for preparing the pudilan mouthwash of claim 1, comprising the steps of:

and (3) before filtering in the step (2), measuring the pH value of the solution, and controlling the pH value to be 5.5-7.5.