CN111358723B - Mouthwash and preparation method thereof - Google Patents
Mouthwash and preparation method thereof Download PDFInfo
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- CN111358723B CN111358723B CN202010294260.XA CN202010294260A CN111358723B CN 111358723 B CN111358723 B CN 111358723B CN 202010294260 A CN202010294260 A CN 202010294260A CN 111358723 B CN111358723 B CN 111358723B
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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Abstract
The invention provides mouthwash and a preparation method thereof, and relates to the field of oral medicine, wherein the mouthwash comprises the following raw materials in parts by weight: 6-12 parts of honeysuckle, 6-18 parts of chrysanthemum, 8-14 parts of ampelopsis grossedentata leaves, 4-15 parts of pseudo-ginseng flowers, 2-7 parts of tea polyphenol, 10-12 parts of chitosan, 1-4 parts of lemon juice, 12-17 parts of sophora flower buds, 3-10 parts of emblic leafflower fruits, 1-3 parts of surfactant and 800 parts of 1500-fold water. The method has the advantages that the utilization rate of the effective components of the raw materials is high, the finally prepared mouthwash has a good anti-inflammatory effect, and a sensitization effect cannot be generated.
Description
Technical Field
The invention relates to the field of oral medicine, in particular to mouthwash and a preparation method thereof.
Background
The mouthwash is one of the ways of cleaning oral health, can inhibit the growth of bacterial plaque, improve the problems of teeth and gums, and promote the oral health, and although the mouthwash cannot replace tooth brushing, the tooth brushing of 2-3 times a day is not enough to achieve good oral and tooth protection effects, so the mouthwash is often used as an auxiliary means besides tooth brushing. There are many kinds of mouthwashes on the market, including non-medicinal mouthwashes mainly for eliminating halitosis and medicinal mouthwashes mainly for treating oral problems such as periodontitis and gingivitis, but although such medicinal mouthwashes have excellent effects in protecting the oral cavity and treating oral problems, their main ingredients often cause various problems, such as: the long-term use of the mouth wash which takes hydrogen peroxide as the main component can cause the demineralization of the tooth surface and the generation of side effects such as black hairy tongue and the like; the use of the mouth wash which takes chlorhexidine as the main component leads to the rise of blood pressure, thereby increasing the probability of heart disease and stroke, and the like. The mouthwash containing ingredients with low side effects also faces various problems, for example, the mouthwash containing iodophors is unstable and inconvenient to prepare immediately before use, while the mouthwash containing essential oil is not suitable for patients who cannot tolerate high-concentration alcohol, so that the mouthwash meets the requirements of some people.
Chinese patent CN105411914A discloses a mouthwash, which comprises the following raw materials in percentage by mass: pseudo-ginseng: 8-10%, wild chrysanthemum flower: 6-8% of honeysuckle flower: 8-12%, mint: 3-5% and chlorhexidine: 3-5% and essential oil: 10-15%, polyoxyethylene hydrogenated castor oil: 3-6%, sodium monofluorophosphate: 0.1-0.2%, deionized water: 38 to 45 percent. The collutory has effects in preventing dental bacteria, eliminating halitosis, clearing away heat and toxic materials, relieving swelling, stopping bleeding, and preventing sensitivity. However, chlorhexidine contained in the mouthwash can cause blood pressure to rise, thereby increasing the probability of heart disease and stroke, and the like.
Chinese patent CN103006525A discloses a mouth wash for removing smoke spots, which comprises mineralized water, additive active ingredients and Chinese herbal medicine extracts, wherein the active ingredients comprise 0.1 part of dextranase, 0.2 part of protease, 0.2 part of sodium hydroxide and 0.05 part of sodium benzoate, the Chinese herbal medicine extracts comprise 3-6 parts of equisetum hiemale, 3-6 parts of black fish bone, 2-3 parts of pseudo-ginseng, 2-3 parts of honeysuckle, 2-3 parts of chrysanthemum, 2-3 parts of Chinese olive, 2-3 parts of borneol, 3-4 parts of Chinese arborvitae twig and 2-3 parts of radix ophiopogonis, and the additives comprise propolis, ethanol, mint, vitamins, clove oil, lemon oil and the like. The mouthwash in the invention can remove the smoke smell of the oral cavity and the smoke stain of the teeth, but the mouthwash contains sodium benzoate, as is known, the sodium benzoate reacts with gastric acid to produce benzoic acid, the benzoic acid has certain toxicity, and can cause chronic benzene poisoning of people after long-term drinking, and although trace amount of sodium benzoate is not harmful to human bodies at present, the situation after long-term use is still uncertain.
Aiming at the problems of large side effect, inconvenience in use, low universality of the latter and the like of the existing mouthwash, the mouthwash which is small in side effect, convenient to use and wide in applicable population needs to be searched urgently, and the public demand is met while a good oral cavity protection effect is obtained.
Disclosure of Invention
The invention provides mouthwash and a preparation method thereof, aiming at the problems in the prior art. The preparation method is simple and efficient, the utilization rate of the effective components of the raw materials is high, the finally prepared mouthwash has a good anti-inflammatory effect, a sensitization effect cannot be generated, and meanwhile, the mouthwash is free of alcohol and preservatives, so that the side effect is small, and the risk of heart disease and stroke is reduced.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows:
the invention provides mouthwash, which comprises the following raw materials in parts by weight: 6-12 parts of honeysuckle, 6-18 parts of chrysanthemum, 8-14 parts of ampelopsis grossedentata leaves, 4-15 parts of pseudo-ginseng flowers, 2-7 parts of tea polyphenol, 10-12 parts of chitosan, 1-4 parts of lemon juice, 12-17 parts of sophora flower buds, 3-10 parts of emblic leafflower fruits, 1-3 parts of surfactant and 800 parts of 1500-fold water.
Further, the mouthwash comprises the following raw materials in parts by weight: 8-10 parts of honeysuckle, 8-15 parts of chrysanthemum, 10-12 parts of ampelopsis grossedentata leaves, 5-13 parts of pseudo-ginseng flowers, 3-6 parts of tea polyphenol, 10-11 parts of chitosan, 2-3 parts of lemon juice, 13-16 parts of sophora flower buds, 4-8 parts of emblic leafflower fruits, 2-3 parts of surfactant and 850 parts of water.
Preferably, the mouthwash comprises the following raw materials in parts by weight: 9 parts of honeysuckle, 9 parts of chrysanthemum, 11 parts of ampelopsis grossedentata leaves, 9 parts of pseudo-ginseng flowers, 5 parts of tea polyphenol, 10 parts of chitosan, 3 parts of lemon juice, 15 parts of sophora flower bud, 5 parts of emblic leafflower fruits, 2 parts of surfactant and 1000 parts of water.
Further, the weight ratio of the honeysuckle to the tea polyphenol to the sophora flower bud is 3-4:1: 6-7.
Preferably, the weight ratio of the honeysuckle to the tea polyphenol to the sophora flower bud is 9:5: 15.
Furthermore, the weight ratio of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves and the pseudo-ginseng flowers is 8-10:8-10:11: 8-10.
Preferably, the weight ratio of the honeysuckle to the chrysanthemum to the Ampelopsis grossedentata leaves to the pseudo-ginseng flowers is 9:9:11: 9.
Further, the weight ratio of the sophora flower bud to the emblic leafflower fruit is 3-5: 1.
Preferably, the weight ratio of the sophora flower bud to the emblic leafflower fruit is 3: 1.
Further, the surfactant is a natural surfactant such as sorbitan fatty acid ester and/or sucrose fatty acid ester.
The invention also provides a preparation method of the mouthwash, which comprises the following steps:
(1) respectively selecting, cleaning and drying honeysuckle, chrysanthemum, ampelopsis grossedentata leaves, pseudo-ginseng flowers, sophora japonica and phyllanthus emblica, then crushing, adding part of lemon juice, adding water for the first time, carrying out first decoction, filtering to obtain a supernatant A and dregs, adding water again to the dregs, carrying out second decoction, and filtering to obtain a supernatant B;
(2) and (2) mixing the supernatant A and the supernatant B obtained in the step (1), sequentially adding the rest lemon juice, tea polyphenol, chitosan, surfactant and the rest water, and mixing and stirring to obtain the mouthwash.
Further, in the step (1), the amount of the water added for the first time is 4-6 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora flower buds and the emblic leafflower fruits, and the amount of the water added for the second time is 5-8 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora flower buds and the emblic leafflower fruits.
Further, in the step (1), the first decoction is carried out for 20-30min after boiling with medium fire, and the second decoction is carried out for 15-20min after boiling with medium fire.
Further, the addition amount of the lemon juice in the step (1) is 20-35% of the total weight of the lemon juice.
Preferably, the lemon juice added in step (1) is 30% of the total weight of the lemon juice.
Further, the crushing in the step (1) refers to crushing the honeysuckle, the chrysanthemum, the pseudo-ginseng flower, the sophora flower bud and the emblic leafflower fruit to 120 meshes; the soaking time is 18-24 h; the filtration uses a 200 mesh screen.
The technical effects obtained by the invention are as follows:
the mouthwash disclosed by the invention adopts pure natural traditional Chinese medicinal materials, tea polyphenol, chitosan and lemon juice are used as auxiliary materials, the components, the proportion and the preparation process of the mouthwash are optimized, the preparation method is simple and efficient, the utilization rate of active ingredients of the raw materials is high, the finally prepared mouthwash has a good anti-inflammatory effect and cannot generate a sensitization effect, and meanwhile, the mouthwash is free of alcohol and preservatives, small in side effect and capable of reducing the risks of heart diseases and stroke.
Detailed Description
It should be noted that the raw materials used in the present invention are all common commercial products, and thus the sources thereof are not particularly limited.
Wherein the lemon juice is 100% freshly squeezed lemon juice.
Example 1
The mouthwash comprises the following raw materials in parts by weight: 6 parts of honeysuckle, 6 parts of chrysanthemum, 8 parts of ampelopsis grossedentata leaves, 4 parts of pseudo-ginseng flowers, 2 parts of tea polyphenol, 10 parts of chitosan, 1 part of lemon juice, 12 parts of sophora flower buds, 3 parts of emblic leafflower fruits, 1 part of sorbitan fatty acid ester and 800 parts of water.
The preparation method of the mouthwash comprises the following steps:
(1) respectively selecting, cleaning and drying honeysuckle, chrysanthemum, ampelopsis grossedentata leaves, pseudo-ginseng flowers, sophora japonica and phyllanthus emblica, then crushing, adding 20% of the total weight of lemon juice, adding water for soaking for 18h for the first time, carrying out first decoction, filtering by a 200-mesh filter screen to obtain supernatant A and dregs, adding water again to the dregs, carrying out second decoction, and filtering by a 200-mesh filter screen to obtain supernatant B; (2) and (2) mixing the supernatant A and the supernatant B obtained in the step (1), sequentially adding the rest lemon juice, tea polyphenol, chitosan, sorbitan fatty acid ester and the rest water, and mixing and stirring to obtain the mouthwash.
Wherein, the amount of the water added for the first time in the step (1) is 4 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits, and the amount of the water added for the second time is 5 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits. The first decoction is carried out for 20min with medium fire after boiling, and the second decoction is carried out for 15min with medium fire after boiling.
Example 2
The mouthwash comprises the following raw materials in parts by weight: 12 parts of honeysuckle, 18 parts of chrysanthemum, 14 parts of ampelopsis grossedentata leaves, 15 parts of pseudo-ginseng flowers, 7 parts of tea polyphenol, 12 parts of chitosan, 4 parts of lemon juice, 17 parts of sophora flower buds, 10 parts of emblic leafflower fruits and 3 parts of fructus phyllanthi
Sucrose fatty acid ester and 1500 parts of water.
The preparation method of the mouthwash comprises the following steps:
(1) respectively selecting, cleaning and drying honeysuckle, chrysanthemum, ampelopsis grossedentata leaves, pseudo-ginseng flowers, sophora japonica and phyllanthus emblica, then crushing, adding 35% of the total weight of lemon juice, adding water for soaking for 24 hours for the first time, carrying out first decoction, filtering by a 200-mesh filter screen to obtain supernatant A and dregs, adding water again to the dregs, carrying out second decoction, and filtering by a 200-mesh filter screen to obtain supernatant B; (2) and (2) mixing the supernatant A and the supernatant B obtained in the step (1), sequentially adding the rest lemon juice, tea polyphenol, chitosan, sucrose fatty acid ester and the rest water, and mixing and stirring to obtain the mouthwash.
Wherein, the amount of the water added for the first time in the step (1) is 6 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits, and the amount of the water added for the second time is 8 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits. The first decoction is carried out for 30min with medium fire after boiling, and the second decoction is carried out for 20min with medium fire after boiling.
Example 3
The mouthwash comprises the following raw materials in parts by weight: 9 parts of honeysuckle, 9 parts of chrysanthemum, 11 parts of ampelopsis grossedentata leaves, 9 parts of pseudo-ginseng flowers, 5 parts of tea polyphenol, 10 parts of chitosan, 3 parts of lemon juice, 15 parts of sophora flower buds, 5 parts of emblic leafflower fruits, 2 parts of sorbitan fatty acid ester and 1000 parts of water.
The preparation method of the mouthwash comprises the following steps:
(1) respectively selecting, cleaning and drying honeysuckle, chrysanthemum, ampelopsis grossedentata leaves, pseudo-ginseng flowers, sophora japonica and phyllanthus emblica, then crushing, adding 30% of the total weight of lemon juice, soaking in water for 20h for the first time, carrying out first decoction, filtering with a 200-mesh filter screen to obtain supernatant A and dregs, adding water again to the dregs, carrying out second decoction, and filtering with a 200-mesh filter screen to obtain supernatant B; (2) and (2) mixing the supernatant A and the supernatant B obtained in the step (1), sequentially adding the rest lemon juice, tea polyphenol, chitosan, sorbitan fatty acid ester and the rest water, and mixing and stirring to obtain the mouthwash.
Wherein, the amount of water added in the step (1) for the first time is 5 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits, and the amount of water added in the step (1) for the second time is 6 times of the total weight of the honeysuckle, the chrysanthemum, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits. The first decoction is carried out for 25min with medium fire after boiling, and the second decoction is carried out for 18min with medium fire after boiling.
Example 4
The mouthwash comprises the following raw materials in parts by weight: 8 parts of honeysuckle, 8 parts of chrysanthemum, 10 parts of ampelopsis grossedentata leaves, 5 parts of pseudo-ginseng flowers, 3 parts of tea polyphenol, 10 parts of chitosan, 2 parts of lemon juice, 13 parts of sophora flower buds, 4 parts of emblic leafflower fruits, 2 parts of sucrose fatty acid ester and 850 parts of water.
The preparation method of the mouthwash comprises the following steps:
(1) respectively selecting, cleaning and drying honeysuckle, chrysanthemum, ampelopsis grossedentata leaves, pseudo-ginseng flowers, sophora japonica and phyllanthus emblica, then crushing, adding 20% of the total weight of lemon juice, adding water for soaking for 19h for the first time, carrying out first decoction, filtering by a 200-mesh filter screen to obtain supernatant A and dregs, adding water again to the dregs, carrying out second decoction, and filtering by a 200-mesh filter screen to obtain supernatant B; (2) and (2) mixing the supernatant A and the supernatant B obtained in the step (1), sequentially adding the rest of lemon juice tea polyphenol, chitosan, sucrose fatty acid ester and the rest of water, and mixing and stirring to obtain the mouthwash.
Wherein, the amount of the water added for the first time in the step (1) is 4 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits, and the amount of the water added for the second time is 5 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits. The first decoction is carried out for 22min with medium fire after boiling, and the second decoction is carried out for 16min with medium fire after boiling.
Example 5
The mouthwash comprises the following raw materials in parts by weight: 10 parts of honeysuckle, 15 parts of chrysanthemum, 12 parts of ampelopsis grossedentata leaves, 13 parts of pseudo-ginseng flowers, 6 parts of tea polyphenol, 11 parts of chitosan, 3 parts of lemon juice, 16 parts of sophora flower buds, 8 parts of emblic leafflower fruits and 3 parts of fructus phyllanthi
Sorbitan fatty acid ester and 1200 parts of water.
The preparation method of the mouthwash comprises the following steps:
(1) respectively selecting, cleaning and drying honeysuckle, chrysanthemum, ampelopsis grossedentata leaves, pseudo-ginseng flowers, sophora japonica and phyllanthus emblica, then crushing, adding 20% of the total weight of lemon juice, adding water for soaking for 22h for the first time, carrying out first decoction, filtering by a 200-mesh filter screen to obtain supernatant A and dregs, adding water again to the dregs, carrying out second decoction, and filtering by a 200-mesh filter screen to obtain supernatant B; (2) and (2) mixing the supernatant A and the supernatant B obtained in the step (1), sequentially adding the rest lemon juice, tea polyphenol, chitosan, sorbitan fatty acid ester and the rest water, and mixing and stirring to obtain the mouthwash.
Wherein, the amount of water added in the step (1) for the first time is 6 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits, and the amount of water added in the step (1) for the second time is 8 times of the total weight of the honeysuckle, the chrysanthemum, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits. The first decoction is carried out for 28min with medium fire after boiling, and the second decoction is carried out for 19min with medium fire after boiling.
Comparative example 1
The mouthwash is different from the mouthwash in example 3 only in that the mouthwash comprises the following raw materials in parts by weight: 5 parts of honeysuckle, 20 parts of chrysanthemum, 6 parts of ampelopsis grossedentata leaves, 18 parts of pseudo-ginseng flowers, 1 part of tea polyphenol, 15 parts of chitosan, 0.8 part of lemon juice, 20 parts of sophora flower bud, 2 parts of emblic leafflower fruits, 5 parts of sorbitan fatty acid ester and 750 parts of water.
Comparative example 2
The mouthwash is different from the mouthwash in example 3 only in that the mouthwash comprises the following raw materials in parts by weight: 15 parts of honeysuckle, 5 parts of chrysanthemum, 15 parts of ampelopsis grossedentata leaves, 3 parts of pseudo-ginseng flowers, 10 parts of tea polyphenol, 8 parts of chitosan, 5 parts of lemon juice and 10 parts of honey
Sophora flower bud, 12 parts of emblic leafflower fruit, 0.8 part of sorbitan fatty acid ester and 1550 parts of water.
Comparative example 3
The difference from example 3 is only that the weight ratio of the honeysuckle, the tea polyphenol and the sophora flower bud is 2:1:8 (the total weight of the honeysuckle, the tea polyphenol and the sophora flower bud is consistent with example 3).
Comparative example 4
The difference from example 3 is only that the weight ratio of the honeysuckle, the chrysanthemum, the Ampelopsis grossedentata leaves and the pseudo-ginseng flowers is 6:12:11:6 (the total weight of the honeysuckle, the chrysanthemum, the Ampelopsis grossedentata leaves and the pseudo-ginseng flowers is the same as that of example 3).
Comparative example 5
The only difference from example 3 is that the weight ratio of sophora flower bud and emblic leafflower fruit is 6:1 (the total weight of sophora flower bud and emblic leafflower fruit is identical to example 3).
Comparative example 6
The only difference from example 3 is that no lemon juice was added in step (1) of the preparation process and the whole lemon juice was used only in step (2).
Anti-inflammatory effect test of mouth wash
Test animals: kunming mouse, male, body weight 20g, total 120;
the test method comprises the following steps: the mice are randomly divided into 12 groups, 10 mice are arranged in each group, wherein 11 groups are respectively coated with the mixed solution of the sample and the inflammatory agent (dimethylbenzene) in the examples 1-5 and the comparative examples 1-6 on the front and back sides of the right ear of the test mouse, the coating amount is 0.02 mL/mouse, the mixed solution of deionized water and the inflammatory agent (dimethylbenzene) in equal volume is coated on the front and back sides of the right ear of the test mouse, the coating amount is 0.02 mL/mouse, the left ear of all the test mice is not treated, the mice are anesthetized and killed after 1h, ears are cut off, the ears of the same part of the ears are punched by a perforator with the diameter of 9mm, and the ears are weighed. Swelling degree (right ear weight-left ear weight), and swelling inhibition rate (blank mouse swelling degree-test mouse swelling degree)/blank mouse swelling degree × 100%, the final results are shown in table 1:
TABLE 1 Effect of mouthwash on swelling of mouse auricles
| Examples of the invention | Swelling degree (mg) | Inhibition ratio (%) |
| Blank control group | 2.56±0.43 | - |
| Example 1 | 1.18±0.29* | 53.91 |
| Example 2 | 1.19±0.30* | 53.52 |
| Example 3 | 1.04±0.21** | 59.38 |
| Example 4 | 1.12±0.25* | 56.25 |
| Example 5 | 1.10±0.24* | 57.03 |
| Comparative example 1 | 1.97±0.37 | 23.05 |
| Comparative example 2 | 1.88±0.39 | 26.56 |
| Comparative example 3 | 1.54±0.35 | 39.84 |
| Comparative example 4 | 1.62±0.31 | 36.72 |
| Comparative example 5 | 1.36±0.29* | 46.88 |
| Comparative example 6 | 1.20±0.24* | 53.13 |
(Note: the swelling degrees in Table 1 are all mean values, compared with the blank control group, P <0.01, P <0.05)
As can be seen from table 1, the mouth rinses prepared in examples 1-5 have good anti-inflammatory effects, and the inhibition rate of the mouth rinse can reach 53.52-59.38%, wherein the mouth rinse of example 3 has the best inhibition rate of 59.38%, and the mouth rinse of comparative examples 1-6 has significantly lower anti-inflammatory effects than the mouth rinse of example 3, although the mouth rinse also has anti-inflammatory effects. Therefore, the mouthwash prepared by reasonably selecting and proportioning the components has a good anti-inflammatory effect, particularly the proportioning among the honeysuckle, the tea polyphenol and the sophora flower bud, the proportioning among the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves and the panax notoginseng flower and the proportioning among the sophora flower bud and the emblic leafflower fruit can greatly influence the anti-inflammatory effect of the mouthwash, and the mouthwash prepared by the technical scheme outside the protection range of the mouthwash has a relatively poor anti-inflammatory effect.
Second, mouthwash sensitization test
Test animals: white guinea pigs, males, 120 in total.
The test method comprises the following steps: hairs of 5cm × 5cm size on the backs of the guinea pigs were removed for use, the guinea pigs were randomly divided into 12 groups of 10 animals each, of which 11 groups were evenly coated with the samples of examples 1 to 5 and comparative examples 1 to 6 on the backs at an administration amount of 0.2mL, the remaining group was set to be a control group which was coated with deionized water only at an equal volume, covered with a paper sulfate, covered with a non-irritant, and the backs of the guinea pigs were washed after 6 hours, and the skin reaction in the test area was observed. No erythema on the backs of the guinea pigs was scored as 0 point, slight erythema was scored as 1 point, marked erythema was scored as 2 points, severe erythema was scored as 3 points, and the test results were counted in Table 2.
TABLE 2
(Note: in Table 2, the skin reaction scores are all the average scores)
As can be seen from Table 2, the mouthwash prepared in the invention has no skin irritation and no sensitization to mice, in each group of mice in comparative examples 1-6, the mouthwash in comparative examples 4-5 is not sensitized, in comparative examples 1-3 and comparative example 6, some mice appear slight erythema or obvious erythema, no mice appear severe erythema, and the sensitization rate reaches 10-50%. Therefore, the mouthwash provided by the invention has no irritation and no allergy to skin through the reasonable principle and proportion of the raw materials, and the raw material proportion or the preparation method outside the protection range of the invention may generate certain skin irritation to further cause anaphylactic reaction.
Finally, it should be noted that the above-mentioned contents are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, and that the simple modifications or equivalent substitutions of the technical solutions of the present invention by those of ordinary skill in the art can be made without departing from the spirit and scope of the technical solutions of the present invention.
Claims (6)
1. A mouthwash, characterized by: the composite material comprises the following raw materials in parts by weight: 6-12 parts of honeysuckle, 6-18 parts of chrysanthemum, 8-14 parts of ampelopsis grossedentata leaves, 4-15 parts of pseudo-ginseng flowers, 2-7 parts of tea polyphenol, 10-12 parts of chitosan, 1-4 parts of lemon juice, 12-17 parts of sophora flower buds, 3-10 parts of emblic leafflower fruits, 1-3 parts of surfactant and 800 parts of 1500-fold water;
the weight ratio of the honeysuckle to the tea polyphenol to the sophora flower bud is 9:5: 15;
the weight ratio of the honeysuckle to the chrysanthemum to the Ampelopsis grossedentata leaves to the pseudo-ginseng flowers is 9:9:11: 9;
the weight ratio of the sophora flower buds to the emblic leafflower fruits is 3: 1;
the preparation method of the mouthwash comprises the following steps:
(1) respectively selecting, cleaning and drying honeysuckle, chrysanthemum, ampelopsis grossedentata leaves, pseudo-ginseng flowers, sophora japonica and phyllanthus emblica, then crushing, adding part of lemon juice, adding water for the first time, carrying out first decoction, filtering to obtain a supernatant A and dregs, adding water again to the dregs, carrying out second decoction, and filtering to obtain a supernatant B;
(2) and (2) mixing the supernatant A and the supernatant B obtained in the step (1), sequentially adding the rest lemon juice, tea polyphenol, chitosan, surfactant and the rest water, and mixing and stirring to obtain the mouthwash.
2. The mouthwash according to claim 1, wherein: the composite material comprises the following raw materials in parts by weight: 8-10 parts of honeysuckle, 8-15 parts of chrysanthemum, 10-12 parts of ampelopsis grossedentata leaves, 5-13 parts of pseudo-ginseng flowers, 3-6 parts of tea polyphenol, 10-11 parts of chitosan, 2-3 parts of lemon juice, 13-16 parts of sophora flower buds, 4-8 parts of emblic leafflower fruits, 2-3 parts of surfactant and 850 parts of water.
3. The mouthwash according to claim 1, wherein: the surfactant is sorbitan fatty acid ester and/or sucrose fatty acid ester.
4. The mouthwash according to claim 1, wherein: in the step (1), the amount of the water added for the first time is 4-6 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits, and the amount of the water added for the second time is 5-8 times of the total weight of the honeysuckle, the chrysanthemum, the ampelopsis grossedentata leaves, the pseudo-ginseng flowers, the sophora japonica and the emblic leafflower fruits.
5. The mouthwash according to claim 1, wherein: in the step (1), the first decoction is carried out for 20-30min by medium fire after boiling, and the second decoction is carried out for 15-20min by medium fire after boiling.
6. The mouthwash according to claim 1, wherein: the addition amount of the lemon juice in the step (1) is 20-35% of the total weight of the lemon juice.
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| CN113116776A (en) * | 2021-04-09 | 2021-07-16 | 云南诺特金参口腔护理用品有限公司 | Mouthwash containing pseudo-ginseng extract and preparation method thereof |
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| CN102784191B (en) * | 2012-08-23 | 2014-12-10 | 成都华神集团股份有限公司制药厂 | Phyllanthus emblica syrup composition and preparation method thereof |
| CN105395422A (en) * | 2015-12-10 | 2016-03-16 | 青岛拓联信息技术有限公司 | Antibacterial anti-inflammation mouth rinse |
| CN105796379A (en) * | 2016-05-06 | 2016-07-27 | 青岛蓝百合生物科技有限公司 | Water soluble chitosan oral care solution and preparation method thereof |
| CN105919829B (en) * | 2016-06-29 | 2018-11-09 | 贵州扬生医用器材有限公司 | A kind of mouthwash and preparation method thereof |
| CN106901360B (en) * | 2017-02-04 | 2020-10-27 | 张家界金驰天问农业科技有限公司 | Ampelopsis grossedentata dry powder and application thereof |
| CN109223663A (en) * | 2018-11-23 | 2019-01-18 | 丹东康齿灵牙膏有限公司 | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis |
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