CN106901360B - Ampelopsis grossedentata dry powder and application thereof - Google Patents
Ampelopsis grossedentata dry powder and application thereof Download PDFInfo
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- CN106901360B CN106901360B CN201710064078.3A CN201710064078A CN106901360B CN 106901360 B CN106901360 B CN 106901360B CN 201710064078 A CN201710064078 A CN 201710064078A CN 106901360 B CN106901360 B CN 106901360B
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- ampelopsis grossedentata
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- 241001018563 Nekemias grossedentata Species 0.000 title claims abstract description 56
- 239000000843 powder Substances 0.000 title claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000000605 extraction Methods 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 238000010298 pulverizing process Methods 0.000 claims abstract description 9
- 239000006228 supernatant Substances 0.000 claims abstract description 8
- 239000002105 nanoparticle Substances 0.000 claims abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 5
- 238000001704 evaporation Methods 0.000 claims abstract description 4
- 238000004108 freeze drying Methods 0.000 claims abstract description 4
- 238000001694 spray drying Methods 0.000 claims abstract description 4
- 208000007117 Oral Ulcer Diseases 0.000 claims description 11
- 208000002399 aphthous stomatitis Diseases 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 2
- 208000025865 Ulcer Diseases 0.000 description 10
- 231100000397 ulcer Toxicity 0.000 description 10
- 239000006189 buccal tablet Substances 0.000 description 7
- 229930003935 flavonoid Natural products 0.000 description 7
- 150000002215 flavonoids Chemical class 0.000 description 7
- 235000017173 flavonoids Nutrition 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 description 7
- 235000013824 polyphenols Nutrition 0.000 description 7
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 6
- 235000015218 chewing gum Nutrition 0.000 description 6
- 229930003944 flavone Natural products 0.000 description 6
- 150000002212 flavone derivatives Chemical class 0.000 description 6
- 235000011949 flavones Nutrition 0.000 description 6
- 239000003826 tablet Substances 0.000 description 6
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 6
- 229940112822 chewing gum Drugs 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 150000004676 glycans Chemical class 0.000 description 5
- 229920001282 polysaccharide Polymers 0.000 description 5
- 239000005017 polysaccharide Substances 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 229940046011 buccal tablet Drugs 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000219099 Parthenocissus quinquefolia Species 0.000 description 2
- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 241001122767 Theaceae Species 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 235000021259 spicy food Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000218922 Magnoliophyta Species 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000020 effect on hyperlipemia Effects 0.000 description 1
- 230000002892 effect on hypertension Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- -1 lipid compounds Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000008486 nectar Nutrition 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000020334 white tea Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a ampelopsis grossedentata dry powder which is prepared by the following steps in sequence: freeze-drying fresh Ampelopsis grossedentata leaves; pulverizing dried Ampelopsis grossedentata leaves into at least 180 meshes, and dispersing with distilled water, wherein the ratio of the fine powder of Ampelopsis grossedentata leaves to the distilled water is 2 g: 30 ml; putting the dispersed fine powder of the ampelopsis grossedentata leaves into a pulverizer, and pulverizing to obtain ampelopsis grossedentata leaf nanoparticles; adding ethanol into Ampelopsis grossedentata leaf nanoparticles to make the final concentration of ethanol be 55% by mass, performing flash extraction for 1.5min, centrifuging the obtained extract at 4000rpm for 15min, and collecting supernatant; placing 200ml of the obtained supernatant into a 500ml round bottom flask, evaporating to dryness under reduced pressure at the vacuum degree of 0.08MPa, the rotation speed of 60rpm and the water bath temperature of 60 ℃, dissolving the residue with 100 ml of distilled water, and spray drying to obtain the ampelopsis grossedentata dry powder.
Description
Technical Field
The invention belongs to the field of food processing, and particularly relates to ampelopsis grossedentata dry powder with high content of active substances of flavone, polysaccharide and polyphenol and application thereof.
Background
Ampelopsis grossedentata (A)Ampelopsis grossedentata) Is a wild vine of angiosperma, dicotyledonous plant, rosaceous, Vitaceae and ampelopsis, also called vine tea, white tea, nectar tea, etc., and is a specific plant in China. The components of Ampelopsis grossedentata are analyzed by Hadoop et al, and it is found that it contains 10% of water-soluble polysaccharides, 20% of polyphenols and 30% of flavonoids (the Chinese food science, 2004, Vol. 4, No. 3, pages 68-71). The flavone, polysaccharide and polyphenol have antioxidant, antibacterial and antitumor activities respectively. Ampelopsis grossedentata has been reported to have the effects of blocking peroxidation of lipid compounds and scavenging free radicals, can maintain normal functions of cell membranes, and has the effects of beautifying and resisting aging; can protect blood vessel from injury by reducing blood vessel fragility and osmotic pressure, thus having good curative effect on hypertension and hyperlipemia.
In order to better exert the physiological activity of the ampelopsis grossedentata, a method for extracting the active ingredients of the ampelopsis grossedentata has been invented. Li Zhong Hai et al studied the influence of different extraction conditions on the extraction rate of the total flavonoids from Ampelopsis grossedentata, and obtained higher extraction rate of the flavonoids, the first extraction rate of total flavonoids and water reached 75.87% and 80.56%, and the sum of the second extraction rates both reached more than 90% (food industry science and technology, No. 27, vol. 12, No. 107-109, p. 111), but this extraction process did not involve the extraction of other effective components. To date, there have been no reports of extracts of Ampelopsis grossedentata with high levels of flavone, polysaccharide and polyphenol actives.
Disclosure of Invention
The invention aims to solve the technical problems in the prior art and provides the dry powder of the ampelopsis grossedentata with high content of active substances of flavone, polysaccharide and polyphenol and the application thereof.
The technical solution of the invention is as follows: the ampelopsis grossedentata dry powder is characterized by being prepared by the following steps in sequence:
a. freeze drying fresh Ampelopsis grossedentata leaves;
b. pulverizing dried Ampelopsis grossedentata leaves into at least 180 meshes to obtain fine powder of Ampelopsis grossedentata leaves, and dispersing with distilled water, wherein the ratio of the fine powder of Ampelopsis grossedentata leaves to the distilled water is 2 g: 30 ml; putting the dispersed fine powder of the ampelopsis grossedentata leaves into a pulverizer, and pulverizing to obtain ampelopsis grossedentata leaf nanoparticles;
c. adding ethanol into Ampelopsis grossedentata leaf nanoparticles to make the final concentration of ethanol be 55% by mass, performing flash extraction for 1.5min, centrifuging the obtained extract at 4000rpm for 15min, and collecting supernatant;
d. placing 200ml of the obtained supernatant into a 500ml round bottom flask, evaporating to dryness under reduced pressure at the vacuum degree of 0.08MPa, the rotation speed of 60rpm and the water bath temperature of 60 ℃, dissolving the residue with 100 ml of distilled water, and spray drying to obtain the ampelopsis grossedentata dry powder.
The ampelopsis grossedentata dry powder is characterized by being applied to preparation of products for preventing and treating oral ulcer.
The ampelopsis grossedentata dry powder obtained by the invention contains high-content active substances (the content of total flavonoids is more than 400mg/g, the content of total sugars is more than 200mg/g, the content of total polyphenols is more than 300mg/g, and the extraction rate of total flavonoids is more than 95%), and the ampelopsis grossedentata dry powder is prepared into buccal tablets, chewing gums and the like, has better health-care effect, and can be applied to preventing and treating pharyngitis, hemostasis and oral ulcer.
Detailed Description
Example 1:
a. freeze drying fresh Ampelopsis grossedentata leaves;
b. pulverizing dried Ampelopsis grossedentata leaves by conventional method, sieving with 180 mesh sieve to obtain fine powder of Ampelopsis grossedentata leaves, dispersing the fine powder of Ampelopsis grossedentata leaves according to the proportion of 2g fine powder and 30mL distilled water, putting into charging tank of HSCS pulverizer, performing ultrafine pulverization at 1200rpm, and pulverizing for 45min to obtain nanometer particles of Ampelopsis grossedentata leaves; the average particle size of the ampelopsis grossedentata leaf particles obtained after crushing is less than 70nm after being measured by a light scattering particle size distribution tester;
c. adding ethanol into Ampelopsis grossedentata leaf nanoparticles to make the final concentration of ethanol be 55% by mass, performing flash extraction for 1.5min, centrifuging the obtained extract at 4000rpm for 15min, and collecting supernatant;
d. placing 200ml of the obtained supernatant into a 500ml round bottom flask, evaporating to dryness under reduced pressure at the vacuum degree of 0.08MPa, the rotation speed of 60rpm and the water bath temperature of 60 ℃, dissolving the residue with 100 ml of distilled water, and spray drying to obtain the ampelopsis grossedentata dry powder.
Detecting the obtained ampelopsis grossedentata dry powder by adopting an aluminum trichloride colorimetric method, wherein the content of total flavonoids is more than 400mg/g, the content of total sugars is more than 200mg/g, and the content of total polyphenols is more than 300 mg/g. Obtaining 0.58g of total flavone from 2g of fine powder, wherein the extraction rate of the total flavone is more than 95 percent.
Application example 1:
chewing gum prepared with the dry powder of ampelopsis grossedentata obtained in example 1: softening edible gum base, adding Ampelopsis grossedentata dry powder, maltose syrup, sugar powder, sorbitol, and edible plasticizer, stirring, keeping water content below 3%, cutting into small pieces, extrusion molding, and packaging to obtain chewing gum.
Clinical cure test:
clinical observations were made on 70 patients with oral ulcers, 31 men and 39 women. The minimum age is 12 years and the maximum age is 53 years. The diameter of the ulcer surface is 2.2mm at the longest and 0.7mm at the shortest. The number of ulcers is at most 7, and at least 1. The longest course of disease is 1 year and half, and the shortest course is 3 days. The treatment group and the control group are randomly divided, 35 cases of the treatment group are given, the chewing gum of the invention is chewed for 2 tablets in the morning, in the middle and at night, and no other medicine is taken. In 35 cases of the control group, the treatment was carried out by the conventional method, and vitamin B tablets and vitamin C tablets were orally administered 3 times a day. The oral cavity is cleaned with normal saline after meals every day, and patients with the Ding advice are prohibited from eating pungent food, spicy food and other pungent food, and are prohibited from smoking and drinking. The results show that: the treatment group had 35 patients, of which 29 had healed the oral ulcer seven days after taking the chewing gum of the present invention, 90% of the ulcer surface had healed seven days after 2 patients, and 50% of the ulcer surface had healed in 4 patients. In 35 patients in the control group, oral ulcers healed after 12 seven days, ulcer surfaces of 50% healed in 17 patients, and 6 patients failed. Therefore, the curative effect of the treatment group is obviously higher than that of the control group.
The results show that: the chewing gum can be used for preventing and treating pharyngitis, hemostasis and oral ulcer.
Application example 2:
buccal tablets are prepared from the dry powder of Ampelopsis grossedentata obtained in example 1: preparing Ampelopsis grossedentata buccal tablet according to a conventional buccal tablet preparation method.
Clinical observations were made on 40 patients with oral ulcers, 20 men and 20 women. The minimum age is 11 years old and the maximum age is 49 years old. The diameter of the ulcer surface is 1.9mm at the longest and 0.6mm at the shortest. The number of ulcers is at most 5, and at least 1. The longest course of disease is 1 year and half, and the shortest course is 3 days. The oral tablets are randomly divided into a treatment group and a control group, 20 cases of the treatment group are given, 2 tablets of ampelopsis grossedentata buccal tablets are chewed respectively in the morning, the noon and the evening, and no other medicine is taken. In 20 control groups, the treatment was carried out by the conventional method, and vitamin B tablets and vitamin C tablets were orally administered 3 times a day. The oral cavity is cleaned with normal saline after meals every day, and patients with the Ding advice are prohibited from eating pungent food, spicy food and other pungent food, and are prohibited from smoking and drinking. The results show that: the oral ulcer of 20 patients in the treatment group is healed after 17 patients take the ampelopsis grossedentata buccal tablet for seven days, 90 percent of the ulcer surface of 2 patients is healed after seven days, and 50 percent of the ulcer surface of 1 patient is healed. Of the 20 patients in the control group, the oral ulcer had healed after 7 seven days, the ulcer surface of 7 patients healed to 50%, and 6 patients were ineffective. Therefore, the curative effect of the treatment group is obviously higher than that of the control group.
The results show that: the buccal tablet can be used for preventing and treating pharyngitis, hemostasis, and oral ulcer.
Claims (1)
1. A ampelopsis grossedentata dry powder for preparing products for preventing and treating oral ulcer is characterized by being prepared by the following steps in sequence:
a. freeze drying fresh Ampelopsis grossedentata leaves;
b. pulverizing dried Ampelopsis grossedentata leaves into at least 180 meshes to obtain fine powder of Ampelopsis grossedentata leaves, and dispersing with distilled water, wherein the ratio of the fine powder of Ampelopsis grossedentata leaves to the distilled water is 2 g: 30 ml; putting the dispersed fine powder of the ampelopsis grossedentata leaves into a pulverizer, and pulverizing to obtain ampelopsis grossedentata leaf nanoparticles;
c. adding ethanol into Ampelopsis grossedentata leaf nanoparticles to make the final concentration of ethanol be 55% by mass, performing flash extraction for 1.5min, centrifuging the obtained extract at 4000rpm for 15min, and collecting supernatant;
d. placing 200ml of the obtained supernatant into a 500ml round bottom flask, evaporating to dryness under reduced pressure at the vacuum degree of 0.08MPa, the rotation speed of 60rpm and the water bath temperature of 60 ℃, dissolving the residue with 100 ml of distilled water, and spray drying to obtain the ampelopsis grossedentata dry powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710064078.3A CN106901360B (en) | 2017-02-04 | 2017-02-04 | Ampelopsis grossedentata dry powder and application thereof |
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| CN201710064078.3A CN106901360B (en) | 2017-02-04 | 2017-02-04 | Ampelopsis grossedentata dry powder and application thereof |
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| CN106901360A CN106901360A (en) | 2017-06-30 |
| CN106901360B true CN106901360B (en) | 2020-10-27 |
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| CN109744493A (en) * | 2019-01-17 | 2019-05-14 | 浙江工商大学 | A kind of food source functionalized nanoparticles and its application |
| CN111358723B (en) * | 2020-04-15 | 2021-03-09 | 武汉森澜生物科技有限公司 | Mouthwash and preparation method thereof |
| CN113288955A (en) * | 2021-06-04 | 2021-08-24 | 贵州中医药大学 | Spray and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1130198C (en) * | 2001-03-30 | 2003-12-10 | 湖南省中医药研究院 | Medicine for treating oral ulcer and its preparing process |
| CN1393443A (en) * | 2001-06-29 | 2003-01-29 | 张友胜 | Process for preparing dihydromyricetin from porcelain ampelopsis |
| CN100337661C (en) * | 2004-06-04 | 2007-09-19 | 澳美制药厂有限公司 | Application of ampelopsis plant and its extract in preparing medicine and health article |
| CN101297900A (en) * | 2008-06-16 | 2008-11-05 | 赵全成 | Medicine new purpose of Ampelopsis Sinica stem leaf total flavones and single component myricetin |
| CN104059161A (en) * | 2014-06-25 | 2014-09-24 | 上海市农业科学院 | Pleurotus eryngii leftover crude polysaccharide and preparation method thereof |
| CN105125755A (en) * | 2015-08-13 | 2015-12-09 | 长春康彼达科技有限公司 | Auxiliary lipid-lowering drug and preparation method thereof |
| CN105153091B (en) * | 2015-08-25 | 2018-06-12 | 华中科技大学同济医学院附属同济医院 | The method for improving dihydromyricetin yield in ampelopsis grossdentata |
| CN105412660A (en) * | 2015-12-14 | 2016-03-23 | 张美华 | Nanometer traditional Chinese medicine composition for nursing after pericarditis surgery and preparation method of composition |
| CN105533002A (en) * | 2016-01-19 | 2016-05-04 | 上海韬鸿化工科技有限公司 | Health tea for treating recurrent aphthous ulcer and preparation method of health tea |
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