CN106901360A - Ampelopsis grossdentata dry powder and purposes - Google Patents
Ampelopsis grossdentata dry powder and purposes Download PDFInfo
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- CN106901360A CN106901360A CN201710064078.3A CN201710064078A CN106901360A CN 106901360 A CN106901360 A CN 106901360A CN 201710064078 A CN201710064078 A CN 201710064078A CN 106901360 A CN106901360 A CN 106901360A
- Authority
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- Prior art keywords
- ampelopsis grossdentata
- ampelopsis
- leaf
- grossdentata leaf
- distilled water
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- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 title claims abstract description 59
- 239000000843 powder Substances 0.000 title claims abstract description 31
- 241000563984 Ampelopsis Species 0.000 title description 8
- 241000219099 Parthenocissus quinquefolia Species 0.000 claims abstract description 51
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 11
- 239000002105 nanoparticle Substances 0.000 claims abstract description 8
- 239000006228 supernatant Substances 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims abstract description 6
- 238000004090 dissolution Methods 0.000 claims abstract description 4
- 239000012467 final product Substances 0.000 claims abstract description 4
- 238000001694 spray drying Methods 0.000 claims abstract description 4
- 239000006185 dispersion Substances 0.000 claims abstract description 3
- 208000025865 Ulcer Diseases 0.000 claims description 15
- 231100000397 ulcer Toxicity 0.000 claims description 15
- 238000004108 freeze drying Methods 0.000 claims description 3
- 229910052573 porcelain Inorganic materials 0.000 claims description 2
- 239000000047 product Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 abstract description 7
- 229930003944 flavone Natural products 0.000 description 13
- 235000011949 flavones Nutrition 0.000 description 13
- 150000002213 flavones Chemical class 0.000 description 7
- 239000007937 lozenge Substances 0.000 description 7
- 150000008442 polyphenolic compounds Chemical class 0.000 description 7
- 235000013824 polyphenols Nutrition 0.000 description 7
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 6
- 208000020670 canker sore Diseases 0.000 description 6
- 229940112822 chewing gum Drugs 0.000 description 6
- 235000015218 chewing gum Nutrition 0.000 description 6
- 150000002212 flavone derivatives Chemical class 0.000 description 6
- 235000013305 food Nutrition 0.000 description 6
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 6
- 150000004676 glycans Chemical class 0.000 description 5
- 229920001282 polysaccharide Polymers 0.000 description 5
- 239000005017 polysaccharide Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 241001018563 Nekemias grossedentata Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- 244000269722 Thea sinensis Species 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- WZZBNLYBHUDSHF-DHLKQENFSA-N 1-[(3s,4s)-4-[8-(2-chloro-4-pyrimidin-2-yloxyphenyl)-7-fluoro-2-methylimidazo[4,5-c]quinolin-1-yl]-3-fluoropiperidin-1-yl]-2-hydroxyethanone Chemical compound CC1=NC2=CN=C3C=C(F)C(C=4C(=CC(OC=5N=CC=CN=5)=CC=4)Cl)=CC3=C2N1[C@H]1CCN(C(=O)CO)C[C@@H]1F WZZBNLYBHUDSHF-DHLKQENFSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000002917 Fraxinus ornus Nutrition 0.000 description 1
- 244000182067 Fraxinus ornus Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241000218922 Magnoliophyta Species 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 235000020429 malt syrup Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000020334 white tea Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a kind of ampelopsis grossdentata dry powder, prepares as follows successively：Freeze fresh ampelopsis grossdentata leaf；Dry ampelopsis grossdentata leaf is ground at least 180 mesh, then is disperseed with distilled water, the ratio of ampelopsis grossdentata leaf fine powder and distilled water is 2g：30ml；By in the ampelopsis grossdentata leaf fine powder input pulverizer after dispersion, smashing obtains ampelopsis grossdentata leaf nano particle；To ethanol is added in ampelopsis grossdentata leaf nano particle, make the mass percent of ethanol final concentration for 55%, homogenate extraction 1.5min, gained extract solution 4000rpm, 15min is centrifuged, take supernatant；Gained supernatant 200ml is placed in 500ml round-bottomed flasks, the evaporated under reduced pressure at vacuum 0.08MPa, rotating speed 60rpm, 60 DEG C of bath temperature, residue obtains final product ampelopsis grossdentata dry powder with 100 ml distilled water dissolutions, spray drying.
Description
Technical field
The invention belongs to food processing field, the especially aobvious tooth of a kind of high content flavones, polysaccharide and polyphenol active material
Porcelain ampelopsis dry powder and purposes.
Background technology
Ampelopsis grossdentata（Ampelopsis grossedentata）It is Angiospermae, Dicotyledoneae, rose Asia
Guiding principle, Vitaceae, a kind of Wild Liane of Ampelopsis, also known as vine tea, white tea, manna tea etc., are Chinese distinctive plants.
The white equality of bear analyzes the composition of ampelopsis grossdentata, it is found that it contains water-soluble polysaccharide 10%, polyphenol content 20%, flavones
Class compound 30%（《Chinese food journal》, the 3rd the 68-71 pages of the phase of volume 4 in 2004）.Flavones, polysaccharide and polyphenol have respectively
Anti-oxidant, bacteriostatic activity, antitumor activity.Having been reported ampelopsis grossdentata has the peroxidating of blocking quasi-grease compound and clear
Except Free Radical, the normal function of cell membrane can be maintained, there is beautifying and anti-aging；Can by reduce fragility of blood vessels and
Osmotic pressure protects the blood vessel to escape injury, thus has good curative effect to hypertension, high fat of blood.
In order to preferably play the physiological activity of ampelopsis grossdentata, people invented to ampelopsis grossdentata effectively into
Divide the method extracted.Li Zhonghai etc. have studied influence of the various extracting conditions to Ampelopsis grossedentata total flavone extraction rate, obtain
Arrived flavones extraction rate higher, extraction general flavone and water leaching rate be up to 75.87% and 80.56% for the first time, secondary extraction rate it
With the two up to more than 90%（《Food industry science and technology》, the 12nd phase 107-109 of volume 27 in 2006, page 111）, but this carries
The process of taking is not directed to other extracts active ingredients.So far, also not on high content flavones, polysaccharide and polyphenol active matter
The relevant report of the Ampelopsis grossdentata (Hand.-Mazz.) W.T.Wang extract of matter.
The content of the invention
The present invention is to solve the above-mentioned technical problem existing for prior art, there is provided a kind of high content flavones, polysaccharide
And the ampelopsis grossdentata dry powder and purposes of polyphenol active material.
Technical solution of the invention is：A kind of ampelopsis grossdentata dry powder, it is characterized in that preparing as follows successively：
A. by fresh ampelopsis grossdentata leaf freeze-drying；
B. dry ampelopsis grossdentata leaf is ground at least 180 mesh, obtains ampelopsis grossdentata leaf fine powder, then disperseed with distilled water,
The ratio of ampelopsis grossdentata leaf fine powder and distilled water is 2g：30ml；Ampelopsis grossdentata leaf fine powder after dispersion is put into pulverizer
In, smashing obtains ampelopsis grossdentata leaf nano particle；
C. to ethanol is added in ampelopsis grossdentata leaf nano particle, the mass percent of ethanol final concentration is made to be 55%, it is flash to carry
1.5min, gained extract solution 4000rpm are taken, 15min is centrifuged, take supernatant；
D. gained supernatant 200ml is placed in 500ml round-bottomed flasks, in vacuum 0.08MPa, rotating speed 60rpm, water-bath temperature
Evaporated under reduced pressure at 60 DEG C of degree, residue obtains final product ampelopsis grossdentata dry powder with 100 ml distilled water dissolutions, spray drying.
A kind of above-mentioned ampelopsis grossdentata dry powder, it is characterised in that the application in anti-treating dental ulcer product is prepared.
The ampelopsis grossdentata dry powder that the present invention is obtained contains the active material of high content（General flavone content is more than 400mg/g,
Total sugar content is more than 200mg/g, and Determination of Polyphenols is more than 300mg/g, general flavone extraction rate more than 95%）, be made into lozenge,
Chewing gum etc. has more preferable health-care effect, can be applied to prevent and treat pharyngitis, hemostasis and canker sore.
Specific embodiment
Embodiment 1：
A. by fresh ampelopsis grossdentata leaf freeze-drying；
B. dry ampelopsis grossdentata leaf is crushed using conventional method, crosses 180 mesh sieves, ampelopsis grossdentata leaf fine powder is obtained, according to 2g
Fine powder adds the ratio of 30mL distilled water to disperse ampelopsis grossdentata leaf fine powder, in input HSCS pulverizer charging tanks, in rotating speed
Ultra-fine grinding is carried out during 1200rpm, 45min is crushed, ampelopsis grossdentata leaf nano particle is obtained；Through light scattering particle size measure of spread
Instrument is determined, and the ampelopsis grossdentata leaf mean particle size of gained is less than 70nm after crushing；
C. to ethanol is added in ampelopsis grossdentata leaf nano particle, the mass percent of ethanol final concentration is made to be 55%, it is flash to carry
1.5min, gained extract solution 4000rpm are taken, 15min is centrifuged, take supernatant；
D. gained supernatant 200ml is placed in 500ml round-bottomed flasks, in vacuum 0.08MPa, rotating speed 60rpm, water-bath temperature
Evaporated under reduced pressure at 60 DEG C of degree, residue obtains final product ampelopsis grossdentata dry powder with 100 ml distilled water dissolutions, spray drying.
Its general flavone content is more than to be detected to gained ampelopsis grossdentata dry powder using alchlor colorimetric method
400mg/g, total sugar content is more than 200mg/g, and Determination of Polyphenols is more than 300mg/g.2g fine powders obtain 0.58g general flavones, general flavone
Extraction rate more than 95%.
Application examples 1：
With chewing gum prepared by the ampelopsis grossdentata dry powder of the gained of embodiment 1：Edible matrix is softened, adds ampelopsis grossdentata to do
Powder, malt syrup, Icing Sugar, sorbierite, edible plasticizer stir, and water tariff collection is cut into small pieces below 3%, is squeezed into
Type, is packaged into ampelopsis grossdentata chewing gum.
Clinical cure is tested：
70 canker sore patients are carried out with clinical observation, man 31, female 39.Age is minimum 12 years old, maximum 53 years old.Ulcer surface
Diameter 2.2mm most long, it is 0.7mm that diameter is most short.Ulcer number is up to 7, and those at least is 1.The course of disease is most long 1 year half, most short by 3
My god.Treatment group and control group are classified as at random, treatment group 35 gives chewing gum of the present invention, early, middle and late to chew clothes mouth respectively
Fragrant sugar 2, any other medicine is not taken.Control group 35, with conventional treatment, gives vitamin B piece, VITAMIN C TABLET
Orally, 3 times a day.Oral cavity is cleaned with physiological saline after meal daily, exhorts that patient such as avoids pungent food at the irritable food, avoids
Tobacco and wine.Result shows：Treatment group 35, wherein 29 take chewing gum of the present invention after seven days canker sore fully recovered, 2 trouble
Person after seven days ulcer surface 90% healed, 4 patient's ulcer surfaces 50% heal.In 35 patients of control group, 12 oral cavities after seven days
Ulcer has been fully recovered, and 17 patient's ulcer surfaces 50% heal, and 6 invalid.Therefore, treatment group's curative effect is apparently higher than control group.
Result shows：Ampelopsis grossdentata chewing gum removes and can be used to prevent and treat pharyngitis, hemostasis, anti-treating dental ulcer.
Application examples 2：
The ampelopsis grossdentata dry powder of the gained of embodiment 1 prepares lozenge：According to conventional process for preparing buccal lozenge, prepare ampelopsis grossdentata and contain
Piece.
40 canker sore patients are carried out with clinical observation, man 20, female 20.Age is minimum 11 years old, maximum 49 years old.Burst
Ulcer face diameter 1.9mm most long, it is 0.6mm that diameter is most short.Ulcer number is up to 5, and those at least is 1.The course of disease is most long 1 year half,
It is most short 3 days.Random to be classified as treatment group and control group, treatment group 20 gives ampelopsis grossdentata lozenge of the present invention, it is early, in,
Evening is chewed take ampelopsis grossdentata lozenge 2 respectively, and any other medicine is not taken.Control group 20, with conventional treatment, gives
Vitamin B piece, VITAMIN C TABLET is oral, and 3 times a day.Oral cavity is cleaned with physiological saline after meal daily, exhorts patient's diet
It is pungent to wait irritable food, avoid tobacco and wine.Result shows：Treatment group 20, wherein 17 are taken ampelopsis grossdentata lozenge of the present invention
Canker sore has been fully recovered after seven days, 2 patients after seven days ulcer surface 90% healed, 1 patient's ulcer surface 50% heals.Control
In 20 patients of group, 7 canker sore after seven days have been fully recovered, and 7 patient's ulcer surfaces 50% heal, and 6 invalid.Therefore, control
Treatment group curative effect is apparently higher than control group.
Result shows：Ampelopsis grossdentata lozenge can be used to prevent and treat pharyngitis, hemostasis, anti-treating dental ulcer.
Claims (2)
1. a kind of ampelopsis grossdentata dry powder, it is characterized in that preparing as follows successively：
A. by fresh ampelopsis grossdentata leaf freeze-drying；
B. by dry ampelopsis grossdentata leaf powder at least 180 mesh, ampelopsis grossdentata leaf fine powder is obtained, then is disperseed with distilled water, shown
The ratio of tooth porcelain ampelopsis leaf fine powder and distilled water is 2g：30ml；By after dispersion ampelopsis grossdentata leaf fine powder input pulverizer in,
Smashing obtains ampelopsis grossdentata leaf nano particle；
C. to ethanol is added in ampelopsis grossdentata leaf nano particle, the mass percent of ethanol final concentration is made to be 55%, it is flash to carry
1.5min, gained extract solution 4000rpm are taken, 15min is centrifuged, take supernatant；
D. gained supernatant 200ml is placed in 500ml round-bottomed flasks, in vacuum 0.08MPa, rotating speed 60rpm, water-bath temperature
Evaporated under reduced pressure at 60 DEG C of degree, residue obtains final product ampelopsis grossdentata dry powder with 100 ml distilled water dissolutions, spray drying.
2. a kind of ampelopsis grossdentata dry powder as claimed in claim 1, it is characterised in that in anti-treating dental ulcer product is prepared
Using.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710064078.3A CN106901360B (en) | 2017-02-04 | 2017-02-04 | Ampelopsis grossedentata dry powder and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710064078.3A CN106901360B (en) | 2017-02-04 | 2017-02-04 | Ampelopsis grossedentata dry powder and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106901360A true CN106901360A (en) | 2017-06-30 |
| CN106901360B CN106901360B (en) | 2020-10-27 |
Family
ID=59208150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710064078.3A Active CN106901360B (en) | 2017-02-04 | 2017-02-04 | Ampelopsis grossedentata dry powder and application thereof |
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| Country | Link |
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| CN (1) | CN106901360B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109744493A (en) * | 2019-01-17 | 2019-05-14 | 浙江工商大学 | A kind of food source functionalized nanoparticles and its application |
| CN111358723A (en) * | 2020-04-15 | 2020-07-03 | 武汉森澜生物科技有限公司 | Mouthwash and preparation method thereof |
| CN113288955A (en) * | 2021-06-04 | 2021-08-24 | 贵州中医药大学 | Spray and preparation method and application thereof |
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Cited By (3)
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| CN111358723A (en) * | 2020-04-15 | 2020-07-03 | 武汉森澜生物科技有限公司 | Mouthwash and preparation method thereof |
| CN113288955A (en) * | 2021-06-04 | 2021-08-24 | 贵州中医药大学 | Spray and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106901360B (en) | 2020-10-27 |
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