CN111514089A

CN111514089A - Oral cavity relieving composition and application and preparation method thereof in oral cavity care product

Info

Publication number: CN111514089A
Application number: CN202010315476.XA
Authority: CN
Inventors: 姜春鹏; 张明磊
Original assignee: Shanghai Lvrui Biotechnology Co ltd
Current assignee: Shanghai Lvrui Biotechnology Co ltd
Priority date: 2020-04-21
Filing date: 2020-04-21
Publication date: 2020-08-11

Abstract

The invention relates to an oral cavity relieving composition, application thereof in oral cavity care products and a preparation method thereof. The oral cavity soothing composition prepared from the bisabolol, the ginger root extract and the propolis extract from natural components has high safety level and does not generate drug resistance, and can be applied to oral cavity care products such as oral cavity spray and mouthwash to effectively relieve oral discomfort symptoms through the synergistic effect of the components. Meanwhile, the oral cavity soothing composition can effectively inhibit the formation of common oral cavity pathogenic bacteria, such as helicobacter pylori, escherichia coli and staphylococcus aureus, can effectively improve and enhance the oral health condition and protect oral mucosa. The oral cavity soothing composition contains nutrient substances such as glucose, fructose, protein, various amino acids, various vitamins, various trace elements and enzymes, improves oral health and becomes a new direction of oral cavity care products. The present invention also provides a method of making an oral care product comprising an oral soothing composition.

Description

Oral cavity relieving composition and application and preparation method thereof in oral cavity care product

Technical Field

The invention relates to the technical field of daily chemical products, in particular to an oral cavity relieving composition, and application and a preparation method thereof in an oral cavity care product.

Background

With the rapid development of social economy, the rhythm of life of people is faster and faster, and a plurality of physical problems are caused by long-term irregularity of work and rest and diet, wherein the oral problems are particularly obvious. Investigations have shown that 50% of office workers have oral problems: halitosis, dry throat, gum swelling and pain, canker sore and the like, and serious and even fatal diseases such as throat inflammation, periodontitis, canceration of ulcer and the like can be further induced, so that the oral health problem is more and more important for people.

Oral pathogenic organisms are a major factor in oral diseases such as halitosis, periodontitis, dental caries, and oral ulcer. Periodontitis is a chronic infectious disease, which is almost 1/4 among people from childhood, and bacterial infection is the underlying cause of periodontitis. Halitosis, dental caries and oral ulcer are also bacterial infectious diseases related to multiple factors. Therefore, it is very important to have a significant therapeutic effect on infectious diseases and oral inflammations caused by bacteria. Although antibiotics such as penicillin, erythromycin, tetracycline, spiramycin and the like and the existing antibacterial components such as triclosan and phenoxyethanol preservatives have certain control effects, the oral micro-ecological flora is easy to generate dependence and drug resistance, and the oral micro-ecological flora can cause imbalance of oral and intestinal flora to cause other diseases after long-term use.

In order to solve the problems, the invention provides an oral cavity relieving composition which adopts natural components of bisabolol, ginger root extract and propolis extract as raw materials, has high safety level and does not generate drug resistance. The oral care product containing the oral cavity relieving composition is safe to human bodies when being applied to oral care products such as oral cavity spray and mouthwash, and the prepared oral care product containing the oral cavity relieving composition can effectively relieve oral discomfort symptoms, improve the oral environment and improve the oral health condition.

Disclosure of Invention

In order to solve the above problems, a first aspect of the present invention provides an oral cavity soothing composition comprising, in weight percent: 10-40% of bisabolol and 60-90% of natural extract.

As a preferable technical scheme, the natural extract is at least one selected from ginger root extract, propolis extract, witch hazel extract and aloe extract.

In a second aspect, the present invention provides an oral care product comprising an oral soothing composition comprising, in parts by weight, at least the following: 0.01-3 parts of the oral cavity relieving composition, 5.01-12.1 parts of humectant, 1-3 parts of solubilizer and 90-100 parts of water.

As a preferable technical scheme, the humectant is at least one selected from glycerin, sorbitol, xylitol, sodium hyaluronate, ethylene glycol and propylene glycol.

As a preferable technical scheme, the humectant contains 4-7 parts by weight of glycerin, 1-5 parts by weight of propylene glycol and 0.01-0.1 part by weight of sodium hyaluronate.

As a preferred technical scheme, the solubilizer is selected from at least one of PEG-40 hydrogenated castor oil, Tween-80 and ethylene glycol.

As a preferable technical proposal, the oral care product containing the oral cavity relaxing composition also comprises 0.01 to 0.2 weight portion of anticaries agent and 0.01 to 0.1 weight portion of sweetening agent.

As a preferable technical scheme, the anticaries agent is at least one selected from sodium monofluorophosphate, sodium fluoride and stannous fluoride.

As a preferable technical scheme, the sweetening agent is at least one selected from xylitol, saccharin sodium, sucralose and glucose.

As a preferred technical scheme, the oral care product containing the oral cavity relaxing composition also comprises 0.1 to 1 weight part of preservative, 0.1 to 1 weight part of foaming agent and 0.05 to 0.5 weight part of aromatic.

In a third aspect of the invention, a method of making an oral care product comprising an oral soothing composition is also provided.

As a preferred embodiment, the oral care product containing the oral cavity soothing composition is a soothing mouthwash, which is prepared by the following steps:

1. adding a solvent and a humectant into a reaction container, and uniformly stirring;

2. under the stirring condition, adding the sweetening agent, the anticaries agent and the preservative into the step 1, and stirring and mixing uniformly;

3. adding the oral cavity relieving composition in the step 2 under stirring, and stirring and mixing uniformly;

4. and (3) adding the foaming agent into the mixture obtained in the step (3) under the condition of stirring, and uniformly stirring and mixing.

5. And (4) adding the solubilizer and the aromatic into the mixture obtained in the step (4) under the condition of stirring, and uniformly stirring and mixing the mixture to obtain the water-soluble organic acid.

As a preferred embodiment, the oral care product containing the oral soothing composition is an oral soothing spray, which is prepared by a method comprising the steps of:

(1) adding a solvent and a humectant into a reaction container, and uniformly stirring;

(2) adding the sweetening agent, the anticarious agent and the preservative into the step (1) under the stirring condition, and uniformly stirring and mixing;

(3) adding the oral cavity relieving composition in the step (2) under stirring, and stirring and mixing uniformly;

(4) and (3) adding the solubilizer and the aromatic into the mixture obtained in the step (3) under the condition of stirring, and uniformly stirring and mixing the mixture to obtain the water-soluble organic acid.

Has the advantages that: the oral cavity soothing composition is prepared by taking the bisabolol, the ginger root extract and the propolis extract from natural ingredients as raw materials, has high safety level and does not generate drug resistance, and can be applied to oral cavity care products such as oral cavity spray and mouthwash, and the oral cavity soothing composition can effectively relieve oral cavity discomfort symptoms such as red and swollen gums, swelling and pain and oral ulcer and the problems of inflammation, halitosis and the like caused by poor oral environment through the synergistic effect of the components. Meanwhile, the oral cavity soothing composition can effectively inhibit the formation of common oral cavity pathogenic bacteria, such as helicobacter pylori, escherichia coli and staphylococcus aureus, can effectively improve and enhance the oral health condition and protect oral mucosa. The oral cavity soothing composition contains nutrients such as glucose, fructose, protein, various amino acids, various vitamins, various trace elements and enzymes, can nourish gums, improve oral health and become a new direction of oral cavity care products. The invention also provides a method of making an oral care product comprising the oral soothing composition.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:

FIG. 1 is a graph showing the bacteriostatic effect of the oral care product prepared in example 1 on H.pylori.

In the figure: a indicates that the oral care product prepared in example 1 was not added, and b indicates that the oral care product prepared in example 1 was added.

FIG. 2 is a graph showing the bacteriostatic effect of the oral care product prepared in example 1 on Escherichia coli.

FIG. 3 is a graph of the bacteriostatic effect of the oral care product prepared in example 1 on Staphylococcus aureus.

Detailed Description

The technical features in the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments, but the scope of protection of the present invention is not limited thereto.

"preferred", "more preferred", and the like, in the present invention, refer to embodiments of the invention that may provide certain benefits, under certain circumstances. However, other embodiments may be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

The invention provides an oral cavity relaxing composition, which comprises the following components in percentage by weight: 10-40% of bisabolol and 60-90% of natural extract.

In a preferred embodiment, the natural extract is at least one selected from the group consisting of ginger root extract, propolis extract, witch hazel extract, and aloe extract.

In a more preferred embodiment, the natural extract is ginger root extract, propolis extract.

In a preferred embodiment, the composition comprises the following components in percentage by weight: 10-40% of bisabolol, 5-20% of ginger root extract and 55-70% of propolis extract.

In a more preferred embodiment, the following ingredients are included in weight percent: 26.64% of bisabolol, 6.66% of ginger root extract and 66.7% of propolis extract.

In a preferred embodiment, the weight ratio of the bisabolol to the ginger root extract to the propolis extract is (3-5): 1: (8-12).

In a preferred embodiment, the method of preparing the oral cavity soothing composition comprises the steps of: mixing bisabolol, rhizoma Zingiberis recens extract and propolis extract under stirring.

Bisabolol

The bisabolol is a natural component existing in chamomile, and the anti-inflammatory effect of chamomile is mainly derived from the bisabolol. Myrrha is oleoresin extracted from trunk and bark of Commiphora myrrha Engl [ C.molmol Engl ] and other plants of Commiphora of Burseraceae. Nature and taste: bitter and neutral. The functional indications are as follows: dispel blood stasis and alleviate pain, resolve swelling and promote tissue regeneration for external use. Can be used for treating traumatic injury, blood stasis, swelling and pain, carbuncle, cellulitis, and pain of chest and abdomen; it is indicated for long-term sore without astringency. The myrrh tree contains 25-35% of resin, 2.5-9% of volatile oil and 57-65% of gum. Wherein the essential components of the volatile oil are hemiterpene and monoterpene, and the monocyclic unsaturated hemiditerpenoid alcohol is the essential component of bisabolol.

The bisabolol is a viscous liquid with colorless to yellow color of rice straw, and has molecular formula of C₁₅H₂₆O, the chemical name is 3-CyClohexene-1-Methanol, a,4-Dimethyl-a- (4-Methyl-3-Pentenyl), the density is 0.922-0.928, the refractive index is 1.492-1.498, the bisabolol is easily soluble in lower alcohol such as ethanol, isopropanol and the like, and simultaneously soluble in fatty alcohol, glyceride and paraffin, the bisabolol has two structures of α -body and β -body, the bisabolol is α -bisabolol, and the anti-inflammatory, anti-fungal, anti-viral and anti-ulcer functions of the volatile oil of the chamomile are mainly from α -bisabolol.

The bisabolol is purchased from demi (shanghai) ltd and is a type of bisabolol.

Ginger root extract

The ginger root is fresh rhizome of Zingiber officinale Roscoe of Zingiberaceae. Nature and taste: pungent and warm. Meridian tropism: it enters lung, spleen and stomach meridians. The functional indications are as follows: relieving exterior syndrome, dispelling cold, arresting vomiting and expelling phlegm. Treating common cold, wind-cold, emesis, phlegm and fluid retention, cough and asthma, distention and diarrhea; rhizoma Pinelliae, rhizoma arisaematis, fish, crab, bird, animal and vegetable botulinum.

Ginger contains volatile components: alpha-zingiberene (alpha-zingiberene), beta-santalol (beta-santalol), beta-phellandrene (beta-phellandrene), beta-bisabolene (beta-bisabolene), alpha-curcumene (alpha-curcumene), gingerol (zingiberol), perillaldehyde (perillaldehyde), neral (neral), geranial (geranial), 2-caranol (2-caranol), 3-caranol, camphene (camphene), beta-ocimene (beta-ocimene), alpha-bergamotene (alpha-bergamotene), beta-farnesene (beta-farnesene), myrcene (myrcene), beta-pinene (beta-pinene), 2-borneol (2-bornenol), citral (7-hecene [7-menthene ], cumenene (7-curcumenol), homoterpene), 1,3,3-trimethyltricyclo [2.2.1.02,6] -heptane [1,3,3-trimethyltricyclo [2.2.1.02,6] heptanes ], ten kinds of 2,6-dimethyl-6- (4-methyl-3-pentenyl) -bicyclo [3.1.1] -2-heptane [2,6-dimethyl-6- (4-methyl-3-pentenyl) -bicyclo [3.1.1] -2-heptene ], 1,3,3-trimethyl-2-oxabicyclo [2.2.2] octane [1,3,3-trimethyl-2-oxabicyclo [2.2.2] octane ], 1- (1, 5-dimethyl-4-hexenyl) -4-methylbenzene [1- (1, 5-dimethyl-4-hexeyl) -4-methylbenezene ], and the like; spicy ingredients: 6-gingerol (6-gingerol), 3-gingerol, 4-gingerol, 5-gingerol, 8-gingerol, 10-gingerol, 12-gingerol, 6-gingerol (6-gingediol), 4-gingerol, 8-gingerol, 10-gingerol, 6-methylhexanediol (6-gingediol), 4-gingerol, 8-gingerol, 6-methylhexanediol, 10-gingediol, 6-methylhexanediol (6-methylgingenediol), 4-gingediol diacetate (4-gingivacetate), 6-gingival diacetate (6-methylgingedioacetate), 6-methylgingediodiacetic acid (6-methylgingedioacetate), 6-gingivanedione (6-gingivandione), 10-gingedione, 6-dehydrogingedione (6-dihydrogingivaridion), 10-dehydrogingerdione, 6-acetylgingerol (6-acetylgingerol), 6-gingerenone (6-shogaol), etc. It also contains various amino acids such as furazageranone (furanomeric), 2-pipecolic acid (pipecolic acid), aspartic acid (aspartic acid), glutamic acid (glutamic acid), and serine (serine).

The ginger root extract is purchased from demi-dian (shanghai) ltd and is a ginger root extract.

Propolis extract

Propolis is a yellow brown or black brown viscous substance secreted by repairing nidus Vespae of Apidae such as Apis cerana Fabricius. The latin plant animal mineral is named Apis cerana Fabr. The product is a resin-like mass, is yellow brown or grey brown, has aromatic odor, is sticky, becomes hard and brittle at low temperature, and can be melted by heating. Is easily dissolved in acetone, benzene, 20% sodium hydroxide solution and ethanol. Nature and taste: slightly sweet and neutral in nature. Meridian tropism: it enters liver and spleen meridians. The functional indications are as follows: moisten skin, promote tissue regeneration, diminish inflammation and relieve pain. Mainly treating gastric ulcer, oral ulcer, cervical erosion, herpes zoster, psoriasis, skin laceration, clavus, and burn and scald.

The propolis contains 50-60% of resin, 30% of beeswax, 10% of aromatic volatile oil and some pollen and other impurities. Mainly contains flavonoids, phenols, lactones, coumarins, aldehydes, ketones and steroids, and also contains vitamin B1, nicotinic acid, provitamin A, various amino acids, sugar, polysaccharide and the like, and 34 essential elements: oxygen, carbon, hydrogen, calcium, phosphorus, nitrogen, potassium, sulfur, sodium, chlorine, magnesium, iron, cobalt, copper, molybdenum, fluorine, aluminum, tin, silicon, arsenic, selenium, titanium, vanadium, chromium, nickel, barium, zirconium, antimony, cadmium, silver, lead, strontium, and the like.

The poplar propolis contains flavone: chrysin (chrysin), populin (protochrysin), alpinia officinarum (zingiberin), alpinia galanga ketol (izalpinin), and the like; birch type propolis contains: benzoic acid (benzoic acid), p-hydroxybenzoic acid (p-hydroxybenzoic acid), p-methoxybenzoic acid (anisic acid), p-coumaric acid (p-coumaric acid), pinosylvin (pinosytrobin), sakuranetin (sakuranetin0, 5-hydroxy-4, 7-dimethoxyflavanone (5-hydroxy-4,7-dimethoxydihydroflavone), 5-hydroxy-4, 7-dimethoxyflavanone (5-hydroxy-4, 7-dimethoxyflavanone), apigenin (apigenin), sophoricidin (acacetin), kaempferide (kaempferide), rhamniferin (rhamnocitrin), 3, 5-dihydroxy-4-7-dimethoxyflavone (3,5-dihydroxy-4,7-dimethoxyflavone), betulin (4, 5-trihydroxy-4, 7-dihydroflavone), betulin (7-hydroxyflavone), 5,7-trihydroxy-6-methoxyflavone, pectolinarin, isorhamnetin, 3-methylrhamnazin, betulin, 5,7-dihydroxy-3,4,6-trimethoxyflavone (5,7-dihydroxy-3,4,6-trimethoxyflavone), kaempferol (kaempferol), acetoxy-alpha-betulin (acetoxy-a-betaenol), and the like. Propolis also contains p-coumarol benzoate (p-coumarol benzoate), galangin (galangin), caffeic acid ester, caffeic acid (caffeic acid), cinnamic acid (cinnamic acid), curcumin (curcumin), quercetin (quercetin), raw pinaflavone (pinocembrin), etc. The Sulian propolis contains volatile oil: α -betulin (α -betulenol), α -bisabolol (α -bisabolol), benzyl alcohol (benzyl alcohol), 2,5-dimethoxybenzyl alcohol (2,5-dimethoxybenzyl alcohol), cinnamyl alcohol (cinnamyl alcohol), betulin (coniferol), benzaldehyde (benzaldehydes), o-coumaric aldehyde (o-coumaric aldehyde), coniferal aldehyde (coniferyl alcohol), benzoic acid, anisic acid (anisic acid), methyl salicylate (methyl salicylate), cyclohexanolate benzoate (cyclohexenol benzoate), cyclohexanolate benzoate, coniferolate benzoate (coniferol benzoate), isovanillin (isovanillin), p-coumaric benzoate (p-coumaric), p-coumaric vinylether (p-coumaryl), and p-coumaric vinyl ether (p-coumaric vinyl benzoate).

The propolis extract is purchased from Lipoid, switzerland and is a propolis extract.

The applicant unexpectedly found that when the oral cavity soothing composition is prepared by using the bisabolol, the ginger root extract and the propolis extract together, and the weight ratio of the bisabolol, the ginger root extract and the propolis extract is controlled to be (3-5): 1: (8-12), the prepared oral cavity soothing composition has excellent anti-inflammatory and bacteriostatic effects, and can well inhibit oral pathogenic bacteria such as helicobacter pylori, escherichia coli, staphylococcus aureus, porphyromonas gingivalis, modified streptococcus, candida albicans and the like. The reason is probably that under specific conditions, the bisabolol, the ginger root extract and the propolis extract are mutually compatible, have good synergistic effect, can inhibit primary reaction of inflammation by regulating cytokines, inhibit IL-1 alpha, IL-1 beta, TNF-alpha and Chlamydia trachomatis mediated HL-60 cells from generating PGE2 to prevent inflammatory reaction, and reduce redness from the source by inhibiting IL-6 and IL-8; meanwhile, the active ingredients in the bisabolol, the ginger root extract and the propolis extract can cooperate with each other to interact with enzymes required by the growth of oral pathogenic bacteria such as helicobacter pylori, escherichia coli, staphylococcus aureus, porphyromonas gingivalis, modified streptococcus, candida albicans and the like, so that the cytoplasm and cell wall of the oral pathogenic bacteria such as the helicobacter pylori, the escherichia coli, the staphylococcus aureus, the porphyromonas gingivalis, the modified streptococcus, the candida albicans and the like are disturbed, and the function of self-synthesized glucosyltransferase is damaged, thereby inhibiting the growth of the oral pathogenic bacteria such as the helicobacter pylori, the escherichia coli, the staphylococcus aureus, the porphyromonas gingivalis, the modified streptococcus, the candida albicans and the like.

In addition, the oral cavity relieving composition is prepared by adopting the bisabolol, the ginger root extract and the propolis extract, and the prepared oral cavity relieving composition also contains nutritional ingredients such as glucose, fructose, protein, various amino acids, various vitamins, various trace elements, enzymes and the like, so that the oral cavity relieving composition can relieve uncomfortable symptoms of the oral cavity, provide nutrition for the oral cavity and nourish gums.

In a preferred embodiment, at least the following ingredients are included in parts by weight: 0.3 part of the oral cavity relieving composition, 8.01 parts of humectant, 2 parts of solubilizer and 88.51 parts of solvent.

Moisture-retaining agent

In a preferred embodiment, the humectant is selected from at least one of glycerin, sorbitol, xylitol, sodium hyaluronate, ethylene glycol, propylene glycol.

In a more preferred embodiment, the humectant is glycerin, propylene glycol, sodium hyaluronate.

In a preferred embodiment, the humectant contains 4-7 parts by weight of glycerin, 1-5 parts by weight of propylene glycol and 0.01-0.1 part by weight of sodium hyaluronate.

In a more preferred embodiment, the humectant contains 5 parts by weight of glycerin, 3 parts by weight of propylene glycol, and 0.01 part by weight of sodium hyaluronate.

The applicant finds that the glycerin, the propylene glycol and the sodium hyaluronate are compounded to serve as the humectant, so that the glycerin, the propylene glycol and the sodium hyaluronate can be cooperated with the oral cavity soothing composition to regulate various inflammatory cells, inhibit the development of oral inflammation, repair the injury of oral gingival tissues and maintain the oral health.

Solubilizer

The solubilizer is a surfactant with solubilizing capability, and a process of increasing the solubility of a slightly soluble agent in a solvent to form a solution under the action of the solubilizer.

In a preferred embodiment, the solubilizer is selected from at least one of PEG-40 hydrogenated castor oil, Tween-80, and ethylene glycol.

In a more preferred embodiment, the solubilizing agent is PEG-40 hydrogenated castor oil.

Solvent(s)

In a preferred embodiment, the solvent is water.

In a preferred embodiment, the oral care product containing the oral soothing composition further comprises 0.01 to 0.2 parts by weight of an anticaries agent and 0.01 to 0.1 parts by weight of a sweetener.

In a more preferred embodiment, the oral care product containing the oral soothing composition further comprises 0.06 parts by weight of an anticaries agent, 0.02 parts by weight of a sweetener.

Anticariogenic agent

In a preferred embodiment, the anticaries agent is selected from at least one of sodium monofluorophosphate, sodium fluoride, stannous fluoride.

In a more preferred embodiment, the anticaries agent is sodium fluoride.

Sweetening agent

In a preferred embodiment, the sweetener is selected from at least one of xylitol, saccharin sodium, sucralose, and glucose.

In a more preferred embodiment, the sweetener is saccharin sodium.

The addition of the sodium fluoride and the saccharin sodium has better synergistic effect with the oral cavity soothing composition, and is beneficial to resisting decayed teeth, repairing enamel and promoting dental tissue health.

In a preferred embodiment, the oral care product containing the oral soothing composition further comprises 0.1 to 1 part by weight of a preservative and 0.05 to 0.5 part by weight of a flavoring agent.

In a more preferred embodiment, the oral care product containing the oral soothing composition further comprises 0.5 parts by weight of a preservative and 0.2 parts by weight of a flavoring agent.

Preservative

In a preferred embodiment, the preservative is selected from at least one of methylparaben, propylparaben, sodium benzoate, potassium sorbate.

In a more preferred embodiment, the preservative is sodium benzoate.

Aromatic agent

Fragrances are substances that impart aromatic properties to products.

In a preferred embodiment, the flavoring agent is a flavorant.

The flavor is not particularly limited in the present invention and may be obtained commercially, for example, commercially available flavors include, but are not limited to, those available from Tianjin Xinnuson biotechnology, Inc.

In a preferred embodiment, the oral care product containing the oral soothing composition further comprises 0.1 to 1 part by weight of a foaming agent.

In a preferred embodiment, the oral care product containing the oral soothing composition further comprises 0.4 parts by weight of a foaming agent.

Foaming agent

In a preferred embodiment, the foaming agent is selected from at least one of sodium laureth sulfate, sodium lauroyl sarcosinate, sodium lauryl sulfonate, and cocamidopropyl betaine.

In a more preferred embodiment, the foaming agent is sodium laureth sulfate, cocamidopropyl betaine.

In a preferred embodiment, the foaming agent contains 0.05-0.7 weight part of sodium laureth sulfate and 0.05-0.3 weight part of cocamidopropyl betaine.

In a more preferred embodiment, the foaming agent comprises 0.3 part by weight of sodium laureth sulfate and 0.1 part by weight of cocamidopropyl betaine.

In a preferred embodiment, the oral care product containing the oral soothing composition is a soothing mouthwash prepared by a method comprising the steps of:

In a preferred embodiment, the oral care product containing the oral soothing composition is an oral soothing spray, which is prepared by a method comprising the steps of:

Hereinafter, the present invention will be described in more detail by way of examples, but it should be understood that these examples are merely illustrative and not restrictive. In addition, all the raw materials are commercially available if not particularly limited.

Examples

Example 1

Embodiment 1 of the present invention provides an oral cavity soothing composition, comprising the following components, by weight: 26.64% of bisabolol, 6.66% of ginger root extract and 66.7% of propolis extract.

The preparation method of the oral cavity relaxing composition comprises the following steps: mixing bisabolol, rhizoma Zingiberis recens extract and propolis extract under stirring.

Example 1 of the present invention also provides an oral soothing spray containing an oral soothing composition, comprising the following ingredients in parts by weight: 0.3 part of the oral cavity relieving composition, 5 parts of glycerol, 3 parts of propylene glycol, 0.01 part of sodium hyaluronate, 2 parts of solubilizer, 88.51 parts of solvent, 0.06 part of anticaries agent, 0.02 part of sweetener, 0.5 part of preservative and 0.2 part of aromatic.

The solubilizer is PEG-40 hydrogenated castor oil.

The solvent is water.

The anticariogenic agent is sodium fluoride.

The sweetener is saccharin sodium.

The preservative is sodium benzoate.

The aromatic is edible essence.

Example 1 of the present invention also provides a method of preparing an oral soothing spray containing an oral soothing composition, comprising the steps of:

Example 2

Embodiment 2 of the present invention provides an oral cavity soothing composition, comprising the following components, by weight: 26.64% of bisabolol, 6.66% of ginger root extract and 66.7% of propolis extract.

Example 2 of the present invention also provides a soothing mouthwash containing the oral soothing composition, comprising the following ingredients in parts by weight: 0.3 part of oral cavity relieving composition, 5 parts of glycerol, 3 parts of propylene glycol, 0.01 part of sodium hyaluronate, 2 parts of solubilizer, 88.51 parts of solvent, 0.06 part of anticaries agent, 0.02 part of sweetener, 0.5 part of preservative, 0.2 part of aromatic and 0.4 part of foaming agent.

The solubilizer is PEG-40 hydrogenated castor oil.

The solvent is water.

The anticariogenic agent is sodium fluoride.

The sweetener is saccharin sodium.

The preservative is sodium benzoate.

The aromatic is edible essence.

The foaming agent is sodium laureth sulfate and cocamidopropyl betaine.

The foaming agent contains 0.3 weight part of sodium laureth sulfate and 0.1 weight part of cocamidopropyl betaine.

Example 2 of the present invention also provides a method of preparing a soothing mouthwash containing an oral soothing composition, comprising the steps of:

Example 3

Example 3 of the present invention provides an oral cavity soothing composition, and also provides an oral care product containing the oral cavity soothing composition and a method for preparing the same, and the specific implementation manner is the same as example 1, except that:

the oral cavity relieving composition comprises the following components in percentage by weight: 80% of bisabolol and 20% of ginger root extract.

The preparation method of the oral cavity relaxing composition comprises the following steps: mixing bisabolol and rhizoma Zingiberis recens extract under stirring.

Example 4

Example 4 of the present invention provides an oral cavity soothing composition, and also provides an oral care product containing the oral cavity soothing composition and a method for preparing the same, and the specific implementation manner is the same as example 1, except that:

the oral cavity relieving composition comprises the following components in percentage by weight: 28.57 percent of bisabolol and 71.43 percent of propolis extract.

The preparation method of the oral cavity relaxing composition comprises the following steps: mixing bisabolol and propolis extract under stirring.

Example 5

Example 5 of the present invention provides an oral cavity soothing composition, and also provides an oral care product containing the oral cavity soothing composition and a method for preparing the same, and the specific implementation manner is the same as example 1, except that:

the oral cavity relieving composition comprises the following components in percentage by weight: ginger root extract 9.09%, propolis extract 90.91%.

The preparation method of the oral cavity relaxing composition comprises the following steps: mixing rhizoma Zingiberis recens extract and propolis extract under stirring.

Example 6

Example 6 of the present invention provides an oral cavity soothing composition, and also provides an oral care product containing the oral cavity soothing composition and a method for preparing the same, and the specific implementation manner is the same as example 1, except that:

the oral cavity relieving composition comprises the following components in percentage by weight: 100% of bisabolol.

Example 7

Example 7 of the present invention provides an oral cavity soothing composition, and also provides an oral care product containing the oral cavity soothing composition and a method for preparing the same, and the specific implementation manner is the same as example 1, except that:

the oral cavity relieving composition comprises the following components in percentage by weight: 100% of ginger root extract.

Example 8

Example 8 of the present invention provides an oral cavity soothing composition, and also provides an oral care product containing the oral cavity soothing composition and a method for preparing the same, and the specific implementation manner is the same as example 1, except that:

the oral cavity relieving composition comprises the following components in percentage by weight: propolis extract 100%.

Example 9

Example 9 of the present invention provides an oral cavity soothing composition, and also provides an oral care product containing the oral cavity soothing composition and a method for preparing the same, and the specific implementation manner is the same as example 1, except that:

the oral cavity relieving composition comprises the following components in percentage by weight: 30% of bisabolol, 50% of ginger root extract and 20% of propolis extract.

Example 10

Example 10 of the present invention provides an oral soothing composition, an oral care product containing the same and a method for preparing the same, and is substantially the same as example 1 except that the sodium fluoride content is replaced with 0 part.

Example 11

Example 11 of the present invention provides an oral cavity soothing composition, and also provides an oral care product containing the oral cavity soothing composition and a method for preparing the same, and the specific embodiment is the same as example 1, except that the content of the sodium hyaluronate is replaced by 0 part.

Performance evaluation

1. Evaluation of antibacterial and bacteriostatic effects

The oral care products containing the oral cavity soothing composition prepared in examples 1-9 were tested for antibacterial and bacteriostatic effects on escherichia coli, staphylococcus aureus, porphyromonas gingivalis, streptococcus mutans, candida albicans, and helicobacter pylori according to QB/T2738-.

The results are shown in Table 1.

TABLE 1 antibacterial and bacteriostatic property test

Wherein A represents helicobacter pylori, B represents Escherichia coli, C represents Staphylococcus aureus, D represents Porphyromonas gingivalis, E represents Streptococcus mutans, and F represents Candida albicans. Helicobacter pylori is a suspected pathogenic bacterium of halitosis, escherichia coli and staphylococcus aureus are suspected pathogenic bacteria related to pyogenic inflammation, porphyromonas gingivalis is a suspected pathogenic bacterium of periodontal inflammation and halitosis, streptococcus mutans is a pathogenic bacterium related to dental caries, and candida albicans is a suspected pathogenic fungus of dental ulcer.

2. Evaluation of Using Effect

(1) 20 subjects without any oral problems were selected and the oral care products containing the oral cavity soothing composition prepared by using example 1 of the present invention were used once a day in the morning, at noon and evening, and kept in the mouth for 2-5min for one month.

(2) 220 subjects suffering from a gingival swelling symptom were selected and divided into 11 groups of 20 persons, and oral care products containing the oral cavity soothing composition prepared according to examples 1 to 11 of the present invention were used once a day in the morning, at noon and at night, respectively, and kept in the mouth for 2 to 5min for one month.

The results are shown in Table 2.

Table 2 results of using the oral care products containing the oral soothing compositions prepared in examples 1-11

The oral care product containing the oral cavity soothing composition prepared using example 1 of the present invention did not have any discomfort, fresh breath and comfort for a subject without any oral problems for one month.

According to experimental results, the oral care product (such as oral spray and mouthwash) containing the oral cavity soothing composition prepared by the invention has obvious antibacterial and bacteriostatic effects, can well inhibit common oral pathogenic bacteria such as escherichia coli, staphylococcus aureus, porphyromonas gingivalis, streptococcus mutans, candida albicans, helicobacter pylori and the like, has a good relieving effect on redness and swelling of gingiva, and is suitable for long-term use.

The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is contemplated, and the examples presented herein are merely illustrative of selected implementations in accordance with all possible combinations of examples. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. The use of some numerical ranges in the claims also includes sub-ranges within their range, and variations in these ranges are also to be construed as being covered by the appended claims where possible.

Claims

1. An oral cavity relieving composition is characterized by comprising the following components in percentage by weight: 10-40% of bisabolol and 60-90% of natural extract.

2. The oral soothing composition of claim 1, wherein the natural extract is selected from at least one of ginger root extract, propolis extract, witch hazel extract, and aloe extract.

3. An oral care product comprising an oral soothing composition characterized by comprising, in parts by weight, at least the following: the oral cavity soothing composition of claim 1 or 2, 0.01-3 parts, 5.01-12.1 parts of humectant, 1-3 parts of solubilizer and 90-100 parts of water.

4. The oral care product of claim 3, wherein the humectant is selected from at least one of glycerin, sorbitol, xylitol, sodium hyaluronate, ethylene glycol, and propylene glycol.

5. The oral care product of claim 4, wherein the humectant comprises 4 to 7 parts by weight glycerin, 1 to 5 parts by weight propylene glycol, and 0.01 to 0.1 parts by weight sodium hyaluronate.

6. The oral care product containing an oral soothing composition according to claim 3, wherein the oral care product containing an oral soothing composition further comprises 0.01 to 0.2 parts by weight of an anticaries agent and 0.01 to 0.1 parts by weight of a sweetener.

7. An oral care product comprising an oral soothing composition according to claim 6, wherein said anticaries agent is selected from at least one of sodium monofluorophosphate, sodium fluoride, stannous fluoride.

8. The oral care product comprising an oral soothing composition according to claim 6, wherein the sweetener is selected from at least one of xylitol, sodium saccharin, sucralose, and glucose.

9. The oral care product of claim 6, further comprising from 0.1 to 1 part by weight of a preservative, from 0.1 to 1 part by weight of a foaming agent, and from 0.05 to 0.5 part by weight of a flavoring agent.

10. The oral care product containing an oral soothing composition according to claim 9, wherein the oral care product containing an oral soothing composition comprises a soothing mouthwash and an oral soothing spray;

the preparation method of the relieving mouthwash comprises the following steps:

5. Under the condition of stirring, adding the solubilizer and the aromatic in the step 4, and stirring and mixing uniformly to obtain the product;

the preparation method of the oral cavity soothing spray comprises the following steps: