CN113712863A - Mild and non-irritant oral mouthwash and preparation method thereof - Google Patents
Mild and non-irritant oral mouthwash and preparation method thereof Download PDFInfo
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- CN113712863A CN113712863A CN202110995711.7A CN202110995711A CN113712863A CN 113712863 A CN113712863 A CN 113712863A CN 202110995711 A CN202110995711 A CN 202110995711A CN 113712863 A CN113712863 A CN 113712863A
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- 229940051866 mouthwash Drugs 0.000 title claims abstract description 82
- 239000002324 mouth wash Substances 0.000 title claims abstract description 80
- 239000002085 irritant Substances 0.000 title claims abstract description 26
- 231100000021 irritant Toxicity 0.000 title claims abstract description 26
- 238000002360 preparation method Methods 0.000 title abstract description 18
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 42
- OJIYIVCMRYCWSE-UHFFFAOYSA-M Domiphen bromide Chemical compound [Br-].CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 OJIYIVCMRYCWSE-UHFFFAOYSA-M 0.000 claims abstract description 34
- 229960001859 domiphen bromide Drugs 0.000 claims abstract description 34
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 23
- 239000011780 sodium chloride Substances 0.000 claims abstract description 21
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 20
- 241000209035 Ilex Species 0.000 claims abstract description 17
- 235000003332 Ilex aquifolium Nutrition 0.000 claims abstract description 17
- 235000002296 Ilex sandwicensis Nutrition 0.000 claims abstract description 17
- 235000002294 Ilex volkensiana Nutrition 0.000 claims abstract description 17
- 239000001509 sodium citrate Substances 0.000 claims abstract description 17
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 17
- 239000004094 surface-active agent Substances 0.000 claims abstract description 17
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 16
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000003906 humectant Substances 0.000 claims abstract description 16
- 239000008367 deionised water Substances 0.000 claims abstract description 11
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 11
- 235000013599 spices Nutrition 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 239000000243 solution Substances 0.000 claims description 48
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 45
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- 210000000214 mouth Anatomy 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 17
- 235000019438 castor oil Nutrition 0.000 claims description 16
- 239000004359 castor oil Substances 0.000 claims description 16
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 12
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 11
- 229960000502 poloxamer Drugs 0.000 claims description 11
- 229920001983 poloxamer Polymers 0.000 claims description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 10
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 10
- 235000011187 glycerol Nutrition 0.000 claims description 10
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 235000010356 sorbitol Nutrition 0.000 claims description 10
- 239000000811 xylitol Substances 0.000 claims description 10
- 235000010447 xylitol Nutrition 0.000 claims description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 10
- 229960002675 xylitol Drugs 0.000 claims description 10
- 239000000796 flavoring agent Substances 0.000 claims description 9
- 235000019634 flavors Nutrition 0.000 claims description 9
- 231100000344 non-irritating Toxicity 0.000 claims description 7
- 229940042585 tocopherol acetate Drugs 0.000 claims description 7
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 5
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 5
- 229960005150 glycerol Drugs 0.000 claims description 5
- 239000008236 heating water Substances 0.000 claims description 5
- 229940041616 menthol Drugs 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 235000013772 propylene glycol Nutrition 0.000 claims description 5
- PHIHRCINWVOECT-UHFFFAOYSA-M sodium 2-hydroxybenzoate 2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound C(C=1C(O)=CC=CC1)(=O)[O-].[Na+].C(CC(O)(C(=O)O)CC(=O)O)(=O)O PHIHRCINWVOECT-UHFFFAOYSA-M 0.000 claims description 5
- 229960002920 sorbitol Drugs 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- CFJYNSNXFXLKNS-UHFFFAOYSA-N p-menthane Chemical compound CC(C)C1CCC(C)CC1 CFJYNSNXFXLKNS-UHFFFAOYSA-N 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 abstract description 10
- 230000006378 damage Effects 0.000 abstract description 9
- 230000036541 health Effects 0.000 abstract description 8
- 206010061218 Inflammation Diseases 0.000 abstract description 7
- 230000004054 inflammatory process Effects 0.000 abstract description 7
- 230000002401 inhibitory effect Effects 0.000 abstract description 7
- 230000003239 periodontal effect Effects 0.000 abstract description 7
- 208000027418 Wounds and injury Diseases 0.000 abstract description 6
- 230000003467 diminishing effect Effects 0.000 abstract description 6
- 208000014674 injury Diseases 0.000 abstract description 6
- 210000004877 mucosa Anatomy 0.000 abstract description 6
- 230000000694 effects Effects 0.000 description 27
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 230000003204 osmotic effect Effects 0.000 description 10
- 230000002195 synergetic effect Effects 0.000 description 10
- 230000006870 function Effects 0.000 description 8
- 239000002304 perfume Substances 0.000 description 7
- 239000003513 alkali Substances 0.000 description 5
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 5
- 230000001680 brushing effect Effects 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 230000007794 irritation Effects 0.000 description 5
- 210000002200 mouth mucosa Anatomy 0.000 description 5
- 210000003296 saliva Anatomy 0.000 description 5
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 description 5
- 230000004936 stimulating effect Effects 0.000 description 5
- 230000003385 bacteriostatic effect Effects 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 210000004195 gingiva Anatomy 0.000 description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
- 229960002216 methylparaben Drugs 0.000 description 4
- 230000000638 stimulation Effects 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 229960000629 domiphen Drugs 0.000 description 3
- YXUPZGKORWTXID-UHFFFAOYSA-N domiphen Chemical compound CCCCCCCCCCCC[N+](C)(C)CCOC1=CC=CC=C1 YXUPZGKORWTXID-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 206010006326 Breath odour Diseases 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 235000019615 sensations Nutrition 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 206010018276 Gingival bleeding Diseases 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000008368 mint flavor Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Oral & Maxillofacial Surgery (AREA)
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Abstract
The invention relates to the technical field of daily necessities, in particular to a mild and non-irritant oral mouthwash and a preparation method thereof, wherein the mild and non-irritant oral mouthwash consists of the following raw materials in percentage by weight, 0.02-1% of domiphen bromide, 10-43% of humectant, 0.5-4% of surfactant, 0.02-2% of sodium chloride, 0.02-2% of tocopheryl acetate, 0.03-1% of sodium citrate, 0.05-0.3% of methyl hydroxybenzoate, 0.01-1% of edible spice, 0.02-5% of ovate leaf holly bark extract and the balance of deionized water; the oral mouthwash has the pH value of 6.0-7.9, and the mild and non-irritant oral mouthwash has the advantages of inhibiting bacteria, diminishing inflammation, repairing mucosa injury, nourishing gums and improving periodontal health; the preparation method can quickly and conveniently prepare the mouthwash.
Description
Technical Field
The invention relates to the technical field of daily necessities, in particular to mild and non-irritant oral mouthwash and a preparation method thereof.
Background
Good oral hygiene is essential to maintain oral health. Studies have shown that the mean plaque clearance after a single brushing is 42%. Because some tooth surfaces are difficult to brush, or because the brushing method of the tooth brushing person is incorrect, the brushing enthusiasm is poor, the compliance is poor, and the like, the maintenance of oral hygiene is often greatly reduced. In addition, the excessive internal heat, periodontitis and low platelet can cause gingival bleeding during tooth brushing, the mouthwash is used for replacing toothpaste, damage to the gingiva can be reduced, and the mouthwash is convenient to carry and free to use.
The mouthwash has the main effects of cleaning teeth, refreshing breath, inhibiting oral bacteria breeding, preventing oral diseases such as periodontal diseases and the like, and is matched with toothpaste to keep the teeth fresh all day long. Therefore, the mouth wash becomes an indispensable oral cavity cleaning and sanitary product in daily life.
Researches show that the mouthwash with antibacterial effect can effectively remove oral bacteria and prevent halitosis, but the existing mouthwash has poor antibacterial effect, often contains ethanol, can cause dryness of the oral cavity, damages a mucus protection layer for keeping the oral cavity moist, causes bad breath and causes stabbing pain. It is not easy to be used as daily nursing for a long time due to the irritation.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide the mild and non-irritant oral mouthwash which has the advantages of inhibiting bacteria, diminishing inflammation, repairing mucosal injury, nourishing gingiva and improving periodontal health.
The invention also aims to provide a preparation method of the mild and non-irritant oral mouthwash, and the method can be used for quickly and conveniently preparing the mouthwash.
In order to achieve one of the above purposes, the invention provides the following technical scheme:
provides a mild and non-irritant oral mouthwash, which consists of the following raw materials in percentage by weight,
0.02 to 1 percent of domiphen bromide
10 to 43 percent of humectant
0.5 to 4 percent of surfactant
0.02 to 2 percent of sodium chloride
0.02 to 2 percent of tocopherol acetate
0.03 to 1 percent of sodium citrate
0.05 to 0.3 percent of methyl hydroxybenzoate
0.01 to 1 percent of edible spice or edible essence
0.02-5% of ovateleaf holly bark extract
The balance of deionized water
The oral cavity mouth wash is 6.0-7.9 in pH.
In the raw materials, the domiphen bromide can inhibit bacteria and diminish inflammation, has the effects of repairing mucosa injury, nourishing gingiva and improving periodontal health, and the efficacy of the domiphen bromide can be further enhanced in the mouthwash with the pH value of 6.0-7.9; the sodium chloride can adjust the osmotic pressure of the mouthwash to be in the osmotic pressure range of saliva, so that the biological activity of the mouthwash in the oral cavity is improved, and the efficacy of the mouthwash is improved; the pH value of the mouthwash controlled by the sodium citrate is 6.0-7.9 in the range of human sialic acid and alkali, so that the mouthwash is prevented from stimulating the oral cavity; the tocopherol acetate and the ovateleaf holly bark extract can supplement vitamins for the oral cavity and have the effects of cooling and disinfecting; the collutory is free of ethanol, has no irritation to oral mucosa, and avoids adverse side effects.
In some embodiments, the humectant consists of glycerin, sorbitol, propylene glycol, and xylitol.
In some embodiments, the surfactant consists of PEG-40 hydrogenated castor oil and poloxamer 127. PEG-40 hydrogenated castor oil has solubilization effect, and the poloxamer 127 not only has dispersion solubilization effect, but also has good surfactant effect.
In some embodiments, the flavor consists of menthol, menthaneformylethylamine, and a flavorant. These flavors can provide a mint flavor.
The mild and non-irritant oral mouthwash disclosed by the invention has the beneficial effects that:
(1) the domiphen bromide oral liquid has the functions of inhibiting bacteria and diminishing inflammation, repairing mucosa damage, nourishing gingiva and improving periodontal health, the effect of the domiphen bromide oral liquid can be further enhanced in the mouthwash with the pH value of 6.0-7.9, and the mouthwash with the pH value of 6.0-7.9 is adaptive to the oral environment and can further improve the effect of the domiphen bromide oral liquid.
(2) The sodium chloride can adjust the osmotic pressure of the mouthwash to be in the range of the osmotic pressure of saliva, and improves the biological activity of the mouthwash in the oral cavity, thereby improving the efficacy of the mouthwash.
(3) The pH value of the sodium citrate is controlled to be 6.0-7.9 within the range of human sialic acid and alkali, so that the mouthwash is prevented from stimulating the oral cavity.
(4) The tocopherol acetate and the ovateleaf holly bark extract can supplement vitamins for the oral cavity and have the effects of cooling and disinfecting.
(5) The mouthwash disclosed by the invention is free of ethanol, has no stimulation to oral mucosa, avoids side effects, is mild and non-irritant, and protects the oral cavity.
In order to achieve the second purpose, the invention provides the following technical scheme:
the preparation method of the mild and non-irritant oral mouthwash comprises the following steps,
s1, weighing domiphen bromide, a humectant, a surfactant, sodium chloride, tocopheryl acetate, sodium hydroxybenzoate citrate, deionized water, a perfume and an ovateleaf holly bark extract according to the formula amount;
s2, mixing and heating water, glycerol, sorbitol, xylitol, poloxamer 127, sodium chloride and the ovate leaf holly bark extract, and stirring to dissolve uniformly to obtain a first solution; mixing and heating PEG-40 hydrogenated castor oil, edible spice, methyl hydroxybenzoate and tocopheryl acetate, and dissolving uniformly to obtain a second solution; adding the second solution into the first solution, and uniformly stirring to obtain a third solution; heating and dissolving the domiphen bromide and the propylene glycol, adding the dissolved domiphen bromide into the third solution, and uniformly stirring to obtain a fourth solution; and adding sodium citrate into the fourth solution, and adjusting the pH value to 6.0-7.9.
In some embodiments, in S2, the domiphen bromide and propylene glycol have a heated dissolution temperature of 50 ℃ to 70 ℃.
In some embodiments, PEG-40 hydrogenated castor oil, flavorant, methylparaben, tocopheryl acetate are mixed and heated to dissolve uniformly at 40 ℃ to 60 ℃ to provide the second solution.
In the preparation method, the components in the mild and non-irritant oral mouthwash are respectively and correspondingly mixed, so that the corresponding synergistic effect is achieved, the components can be fully mixed, and the synergistic effect is generated among the components.
The preparation method of the mild and non-irritant oral mouthwash has the beneficial effects that:
(1) the preparation method of the invention respectively and correspondingly mixes the components in the mild and non-irritant oral mouthwash, thereby playing a role in corresponding synergism, not only fully mixing the components, but also generating a synergistic effect among the components.
(2) The preparation method of the invention obtains corresponding synergistic function by step mixing, is easy to operate and is suitable for large-scale production and application.
Detailed Description
The present invention will be described in detail with reference to specific examples.
Example 1
The embodiment discloses a mild and non-irritant oral mouthwash, which consists of the following raw materials in percentage by weight,
domiphen bromide 0.05%, humectant 23.36%, surfactant 0.5%, sodium chloride 1.2%, tocopheryl acetate 0.02%, sodium citrate 0.6%, methyl hydroxybenzoate 0.1%, edible perfume 0.01%, cortex Ilicis Rotundae extract 0.02%, and balance deionized water; the oral cavity mouth wash is 6.0-7.9 in pH.
The functions and effects of the raw materials are as follows: domiphen bromide is added, so that the effects of inhibiting bacteria, diminishing inflammation, repairing mucosa injury, nourishing gum and improving periodontal health can be achieved; adding sodium chloride, and adjusting the osmotic pressure of the mouthwash to be within the osmotic pressure range of saliva; the sodium citrate is added, so that the pH value of the mouthwash can be controlled, and the pH value of the mouthwash is controlled within the range of human sialic acid and alkali, namely, the pH value is 6.0-7.9, the mouthwash is prevented from stimulating the oral cavity, and the activity of domiphen can be improved when the pH value is 6.0-7.9; the oral bacteriostatic mouth wash does not contain ethanol, has no stimulation to oral mucosa, and avoids bringing side effects.
In this embodiment, the humectant consists of glycerin, sorbitol, propylene glycol, and xylitol.
In this example, the surfactant consisted of PEG-40 hydrogenated castor oil and poloxamer 127.
In this embodiment, the flavor consists of menthol, menthane formylethylamine, and a flavoring essence.
The preparation method of the mild and non-irritant oral mouthwash comprises the following steps,
s1, weighing domiphen bromide, a humectant, a surfactant, sodium chloride, tocopheryl acetate, sodium hydroxybenzoate citrate, deionized water, a perfume and an ovateleaf holly bark extract according to the formula amount;
s2, mixing and heating water, glycerol, sorbitol, xylitol, poloxamer 127, sodium chloride and the ovate leaf holly bark extract, and stirring to dissolve uniformly to obtain a first solution; mixing and heating PEG-40 hydrogenated castor oil, edible spice, methyl hydroxybenzoate and tocopheryl acetate, and dissolving uniformly to obtain a second solution; adding the second solution into the first solution, and uniformly stirring to obtain a third solution; heating and dissolving the domiphen bromide and the propylene glycol, adding the dissolved domiphen bromide into the third solution, and uniformly stirring to obtain a fourth solution; and adding sodium citrate into the fourth solution, and adjusting the pH value to 6.0-7.9.
The preparation method has the following functions and effects: the components in the mild and non-irritant oral mouthwash are respectively and correspondingly mixed, so that the corresponding synergistic effect is achieved, the components can be fully mixed, and the synergistic effect is generated among the components.
In this embodiment, in S2, the heating and dissolution temperature of domiphen bromide and propylene glycol is 60 ℃.
In this example, in S2, PEG-40 hydrogenated castor oil, flavor, methylparaben, and tocopheryl acetate were mixed and dissolved by heating at 55 ℃ to obtain the second solution.
Example 2
The embodiment discloses a mild and non-irritant oral mouthwash, which consists of the following raw materials in percentage by weight,
domiphen bromide 0.1%, humectant 43%, surfactant 4%, sodium chloride 1%, tocopherol acetate 1%, sodium citrate 0.4%, methyl hydroxybenzoate 0.05%, edible spice 1%, ovate leaf holly bark extract 5%, and the balance of deionized water; the oral cavity mouth wash is 6.0-7.9 in pH.
The functions and effects of the raw materials are as follows: domiphen bromide is added, so that the effects of inhibiting bacteria, diminishing inflammation, repairing mucosa injury, nourishing gum and improving periodontal health can be achieved; adding sodium chloride, and adjusting the osmotic pressure of the mouthwash to be within the osmotic pressure range of saliva; the sodium citrate is added, so that the pH value of the mouthwash can be controlled, and the pH value of the mouthwash is controlled within the range of human sialic acid and alkali, namely, the pH value is 6.0-7.9, the mouthwash is prevented from stimulating the oral cavity, and the activity of domiphen can be improved when the pH value is 6.0-7.9; the oral bacteriostatic mouth wash does not contain ethanol, has no stimulation to oral mucosa, and avoids bringing side effects.
In this embodiment, the humectant consists of glycerin, sorbitol, propylene glycol, and xylitol.
In this example, the surfactant consisted of PEG-40 hydrogenated castor oil and poloxamer 127.
In this embodiment, the flavor consists of menthol, menthane formylethylamine, and a flavoring essence.
The preparation method of the mild and non-irritant oral mouthwash comprises the following steps,
s1, weighing domiphen bromide, a humectant, a surfactant, sodium chloride, tocopheryl acetate, sodium hydroxybenzoate citrate, deionized water, a perfume and an ovateleaf holly bark extract according to the formula amount;
s2, mixing and heating water, glycerol, sorbitol, xylitol, poloxamer 127, sodium chloride and the ovate leaf holly bark extract, and stirring to dissolve uniformly to obtain a first solution; mixing and heating PEG-40 hydrogenated castor oil, edible spice, methyl hydroxybenzoate and tocopheryl acetate, and dissolving uniformly to obtain a second solution; adding the second solution into the first solution, and uniformly stirring to obtain a third solution; heating and dissolving the domiphen bromide and the propylene glycol, adding the dissolved domiphen bromide into the third solution, and uniformly stirring to obtain a fourth solution; and adding sodium citrate into the fourth solution, and adjusting the pH value to 6.0-7.9.
The preparation method has the following functions and effects: the components in the mild and non-irritant oral mouthwash are respectively and correspondingly mixed, so that the corresponding synergistic effect is achieved, the components can be fully mixed, and the synergistic effect is generated among the components.
In this embodiment, in S2, the heating and dissolution temperature of domiphen bromide and propylene glycol is 70 ℃.
In this example, in S2, PEG-40 hydrogenated castor oil, perfume, methylparaben, and tocopheryl acetate were mixed and dissolved by heating at 60 ℃ to obtain the second solution.
Example 3
The embodiment discloses a mild and non-irritant oral mouthwash, which consists of the following raw materials in percentage by weight,
domiphen bromide 0.15%, humectant 22%, surfactant 3%, sodium chloride 0.5%, tocopherol acetate 0.5%, sodium citrate 4%, methyl hydroxybenzoate 0.2%, edible spice 0.05%, ovate leaf holly bark extract 0.01%, and the balance of deionized water; the oral cavity mouth wash is 6.0-7.9 in pH.
The functions and effects of the raw materials are as follows: domiphen bromide is added, so that the effects of inhibiting bacteria, diminishing inflammation, repairing mucosa injury, nourishing gum and improving periodontal health can be achieved; adding sodium chloride, and adjusting the osmotic pressure of the mouthwash to be within the osmotic pressure range of saliva; the sodium citrate is added, so that the pH value of the mouthwash can be controlled, and the pH value of the mouthwash is controlled within the range of human sialic acid and alkali, namely, the pH value is 6.0-7.9, the mouthwash is prevented from stimulating the oral cavity, and the activity of domiphen can be improved when the pH value is 6.0-7.9; the oral bacteriostatic mouth wash does not contain ethanol, has no stimulation to oral mucosa, and avoids bringing side effects.
In this embodiment, the humectant consists of glycerin, sorbitol, propylene glycol, and xylitol.
In this example, the surfactant consisted of PEG-40 hydrogenated castor oil and poloxamer 127.
In this embodiment, the flavor consists of menthol, menthane formylethylamine, and a flavoring essence.
The preparation method of the mild and non-irritant oral mouthwash comprises the following steps,
s1, weighing domiphen bromide, a humectant, a surfactant, sodium chloride, tocopheryl acetate, sodium hydroxybenzoate citrate, deionized water, a perfume and an ovateleaf holly bark extract according to the formula amount;
s2, mixing and heating water, glycerol, sorbitol, xylitol, poloxamer 127, sodium chloride and the ovate leaf holly bark extract, and stirring to dissolve uniformly to obtain a first solution; mixing and heating PEG-40 hydrogenated castor oil, edible spice, methyl hydroxybenzoate and tocopheryl acetate, and dissolving uniformly to obtain a second solution; adding the second solution into the first solution, and uniformly stirring to obtain a third solution; heating and dissolving the domiphen bromide and the propylene glycol, adding the dissolved domiphen bromide into the third solution, and uniformly stirring to obtain a fourth solution; and adding sodium citrate into the fourth solution, and adjusting the pH value to 6.0-7.9.
The preparation method has the following functions and effects: the components in the mild and non-irritant oral mouthwash are respectively and correspondingly mixed, so that the corresponding synergistic effect is achieved, the components can be fully mixed, and the synergistic effect is generated among the components.
In this embodiment, in S2, the heating and dissolution temperature of domiphen bromide and propylene glycol is 50 ℃.
In this example, in S2, PEG-40 hydrogenated castor oil, perfume, methylparaben, and tocopheryl acetate were mixed and dissolved uniformly by heating at 40 ℃ to obtain the second solution.
Comparative example 1
Comparative example 1 is different from example 1 in that sodium citrate is subtracted, other components and preparation method are the same as example 1, and detailed description is omitted.
Comparison of effects
Firstly, in order to verify the bacteriostatic effect of the mild and non-irritant oral mouthwash disclosed by the invention, the following tests are adopted:
(1) the oral mouthwash prepared in example 1 is used for respectively treating escherichia coli, staphylococcus aureus and candida albicans for 10min, 15min, 20min and 25 min;
(2) the oral mouthwash prepared in comparative example 1 is used for respectively treating escherichia coli, staphylococcus aureus and candida albicans for 10min, 15min, 20min and 25 min;
(3) the sterilization of each bacterium was observed, and the obtained number of sterilizations was shown in tables 1-2.
TABLE 1
TABLE 2
As can be seen from tables 1 and 2, the mouthwash disclosed by the invention has a better antibacterial effect in an environment with a pH value of 6.0-7.9.
Secondly, in order to verify the mildness of the mild and non-irritating oral mouthwash disclosed by the invention, the following tests are adopted:
10 subjects were selected, and the 10 subjects were rinsed with the mouthwash of example 1 for 1 hour and then rinsed with the mouthwash of comparative example 1; the two gargling operations were performed with mouthwash for 5min, and the irritation was self-assessed.
The subjects responded that the irritation sensation using the mouthwash of example 1 was milder than the irritation sensation using the mouthwash of comparative example 1, and it was seen that the mouthwash of the present invention was mild and non-irritating, and better protected the oral cavity.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the protection scope of the present invention, although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (6)
1. A mild and non-irritant oral mouthwash is characterized in that: consists of the following raw materials in percentage by weight,
0.02 to 1 percent of domiphen bromide
10 to 43 percent of humectant
0.5 to 4 percent of surfactant
0.02 to 2 percent of sodium chloride
0.02 to 2 percent of tocopherol acetate
0.03 to 1 percent of sodium citrate
0.05 to 0.3 percent of methyl hydroxybenzoate
0.01 to 1 percent of edible spice
0.02-5% of ovateleaf holly bark extract
The balance of deionized water
The pH value of the oral cavity mouth wash is 6.0-7.9;
the surfactant is composed of PEG-40 hydrogenated castor oil and poloxamer 127.
2. The mild, non-irritating oral mouthwash according to claim 1, wherein: the humectant consists of glycerin, sorbitol, propylene glycol and xylitol.
3. The mild, non-irritating oral mouthwash according to claim 1, wherein: the edible spice consists of menthol, menthane formylethylamine and edible essence.
4. The method for preparing the mild and non-irritating oral mouthwash of any one of claims 1 to 3, wherein: comprises the following steps of (a) carrying out,
s1, weighing domiphen bromide, a humectant, a surfactant, sodium chloride, tocopheryl acetate, sodium hydroxybenzoate citrate, deionized water, a flavoring and an ovateleaf holly bark extract according to the formula amount;
s2, mixing and heating water, glycerol, sorbitol, xylitol, poloxamer 127, sodium chloride and the ovate leaf holly bark extract, and stirring to dissolve uniformly to obtain a first solution; mixing and heating PEG-40 hydrogenated castor oil, edible spice, methyl hydroxybenzoate and tocopheryl acetate, and dissolving uniformly to obtain a second solution; adding the second solution into the first solution, and uniformly stirring to obtain a third solution; heating and dissolving the domiphen bromide and the propylene glycol, adding the dissolved domiphen bromide into the third solution, and uniformly stirring to obtain a fourth solution; and adding sodium citrate into the fourth solution, and adjusting the pH value to 6.0-7.9.
5. The method of preparing a mild, non-irritating oral rinse according to claim 4, wherein: in the S2, the heating and dissolving temperature of the domiphen bromide and the propylene glycol is 50-70 ℃.
6. The method of preparing a mild, non-irritating oral rinse according to claim 4, wherein: in the S2, PEG-40 hydrogenated castor oil, edible flavor, methyl hydroxybenzoate and tocopherol acetate are mixed and heated at 40-60 ℃ to be dissolved uniformly, so that the second solution is obtained.
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