JP2004026701A - Composition for oral cavity - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a composition which is used for oral cavities and has the bitter ingredient (foaming agent or various surfactants)-reducing effect of a lactobacillus cocultivation product extract and the biologically mild remarkable clinical effects of medicinal herb ingredients, such as the comprehensive cleaning and washing effects of aloe ingredients and the hemostatic and gum tightening-improving effect of Artemisia princeps ingredients. <P>SOLUTION: This composition for the oral cavities is characterized by containing the lactobacillus cocultivation product extract and/or the aloe extract and/or the Artemisia princeps extract and/or a mushroom extract. <P>COPYRIGHT: (C)2004,JPO

Description

[0001]
TECHNICAL FIELD The present invention relates to an oral composition.
[0002]
2. Description of the Related Art Conventionally, a number of compositions have been studied as oral compositions, but they are gentle to living organisms and prevent periodontal diseases and their decay, as well as prevent tooth decay, and are used to tighten gums and gums. There is no oral composition containing herbs or herbs that exert excellent effects in the area.
[0003]
Therefore, the inventor of the present application has proposed that instead of chemically synthesized chemicals as a medicinal component, the present invention is biologically friendly, has no side effects, and has physiological and clinical effects. The present invention has been completed by focusing on adding an aloe, mugwort, and lactic acid bacteria co-cultivated extract, the effect of which has been accepted, to an existing oral composition.
[0004]
The present invention relates to an oral composition containing a lactic acid bacteria co-cultivation extract and / or an aloe extract and / or a mugwort extract and / or a mushroom extract. It is preferable that an extract of aloe and / or extract of mugwort and / or an extract of mushroom are further added to the culture extract, and a extract obtained by adding extract of aloe and mugwort to the extract of symbiotic culture of lactic acid bacteria is further added. Is particularly preferred.
The oral composition refers to mouthwash, water polish, toothpaste, liquid toothpaste, toothpaste, gingival coating, spray, and the like.
[0005]
BEST MODE FOR CARRYING OUT THE INVENTION The co-cultivated extract of lactic acid bacteria used in the present invention includes, for example, 12 kinds of lactic acid bacteria carefully selected from many effective bacteria described in JP-A-2001-224330. It is preferable to use products and secretions obtained by co-cultivating soybeans and oligosaccharides with four types of yeasts in a medium. The co-cultivated extract used in the present invention is a product obtained by co-cultivating lactic acid bacteria and yeast, a secretion, which has not only an antibacterial effect and a bactericidal effect, but also 20 or more amino acids, Contains vitamins, various minerals, nucleic acids and other trace biological elements. (See "Constitution Improvement Health Act", published in Natural Medicine Clinical Prevention Research Report).
Further, an amino acid which is one of the components is a component of a protein which is one of the three major nutrients of the living body. The protein is composed of about 20 kinds of amino acids, specifically, arginine, lysine, histidine, phenylalanine, tyrosine, leucine, Analysis has revealed that isoleucine, methionine, valine, alanine, glycine, proline, glutamic acid, serine, threonine, aspartic acid, tryptophan and cystine, glutamine, asparagine and the like are included.
Furthermore, it contains a large amount of important nucleic acid components that transmit gene information and give instructions, such as deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) that acts as a messenger for determining the type of protein. . And this nucleic acid activates normal division of human body cells, prevents aging by increasing energy consumption, prevents obesity, prevents infectious diseases by improving immunity, prevents diabetes by improving hormonal balance, and improves intestinal beneficial bacteria. It has been proven to be effective in increasing the number of cells and activating nerve cells, and the inventors of the present application have also experimentally confirmed the effects.
As a result, if the body lacks nucleic acids, which are said to be the source of life, the production and proliferation of cells will be extremely adversely affected.Therefore, by constantly taking this extract into the body through the gums and gums into the periodontium, unexpected The effect has been confirmed by many users.
Further, specifically describing one of the components, minerals, and vitamins, in addition to phosphorus, calcium, magnesium, sodium, and potassium, examples of the vitamins include biotin, medicinal acid, vantothenic acid, and niacin. . Further, fatty acids include butyric acid, acetic acid, propionic acid, lactic acid and the like. In addition, the lactic acid bacteria co-cultivation culture or extract thereof used in the present invention was analyzed and confirmed that, in addition to the above-mentioned components, the sugar chain itself and amino sugars were present as sugar chains. I have.
[0006]
The mugworts used in the present invention are not particularly limited, and it is preferable to use those extracted, but they may be liquid or solid such as powder.
[0007]
The aloe used in the invention of the present application is not particularly limited, and a favorable effect can be obtained as long as the aloe is used. However, from the viewpoint of the effects related to the prevention and treatment of dentistry, aloe vera and kidachi aloe are particularly preferred.
It is preferable to use the extracted aloe, but it may be liquid or solid such as powder.
[0008]
As the mushrooms used in the present invention, mushrooms containing a large amount of β-glucagon which is a kind of mucopolysaccharide, Agaricus blazei, Sarnoshikokake and Shiitake, Maitake are preferable, and extracts from these are liquid or powdery. It may be a solid such as.
The extraction extract of the invention of this application is carried out by ordinary extraction means such as alcohol or water at a heated or normal temperature.
[0009]
The oral composition of the present invention includes, besides the medicinal component, any known components such as mouthwash, toothpaste, liquid dentifrice, powdered dentifrice, gingival coating agent, etc. Humectants, foaming agents, binders, flavoring agents, bactericides, preservatives, cleaning agents, and the like can be blended at ordinary doses.
[0010]
As abrasives, calcium hydrogen phosphate, heavy calcium carbonate, light calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, potassium metaphosphate, silicic anhydride, hydrous silicic acid, aluminum silicate, calcium silicate, zirconium silicate , Bentonite, zeolite, aluminum oxide, aluminum hydroxide, alumina, resin, and mixtures thereof.
[0011]
Known foaming agents such as polyglycerin and sodium lauryl sulfate are used as the foaming agent.
[0012]
As the wetting agent, polyethylene glycol, propylene glycol, sorbitol, glycerin, maltitol, xylitol and the like are used.
[0013]
Usable binders include conventional carboxymethylcellulose sodium, sodium alginate and carboxyvinyl polymers.
Sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, alginate, carrageenan, acacia, polyvinyl alcohol, tragacanth gum, starch, sodium polyacrylate and the like are used.
[0014]
As a bactericide, chlorhexidine salts, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride and the like are used.
[0015]
As the preservative, parahydroxybenzoic acid and its ester, sodium benzoate and the like are used, and as the sweetener, lacquer extract, saccharin, saccharin sodium, stepia, berraltine and the like are used.
[0016]
Surfactants include alkyl sulfates, alkyl benzene sulfonates, monoalkyl phosphates, N-acyl sarcosinates, N-acyl glutamates, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymers. Coupling (pluronic type), sucrose fatty acid ester, alkyl glycosides, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyldimethylamine oxide, carbobetaine, hydroxycarbobetaine, phosphobetaine, hydroxyphosphobetaine, sulfobetaine, hydroxysulfo Betaine or the like is used. Among these, water-soluble nonionic surfactants such as polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, sucrose fatty acid ester, alkyl glycosides, sorbitan fatty acid ester, and polyoxyethylene sorbitan fatty acid ester, An amphoteric surfactant or the like is used.
[0017]
Examples of spices include natural spices such as spearmint oil, peppermint oil, linalool, winder green oil, sassafras oil, clove oil, sage oil, eucalyptus oil, mayola oil, cinnamon oil, thyme oil, lemon oil and orange oil; Menthol, anethole, carvone, eugenol, thymol, methyl salicylate and the like are used.
[0018]
As the sweetener, saccharin, saccharin sodium, stevioside, neohesperidyl dihydrochalcone, berraltin, p-methoxycinnamic aldehyde, glycyrrhizinate, aspartame (aspartylphenylalanine methyl ester) and the like are used.
[0019]
As the fluoride, sodium fluoride, sodium monofluorophosphate and the like are used.
[0020]
Other active ingredients include chlorophyll compounds, ε-aminocaproic acid, tranexamic acid, vitamin C, vitamin E, nicotinic acid ester, allantoinchlorohydroxyaluminum, azulene, lysozyme chloride, hinokitiol, β-glycyrrhetinic acid, dipotassium glycyrrhizinate, protease For example, plant extracts having a caries preventive action are used.
[0021]
Examples of plants include witch hazel, witch hazel, hamamelis, and the like as plants of the family hagaceae, as well as plants of the family Lamiaceae, such as koganebana, perilla, salvia, sage, rosemary, lavender, basil, and the like, and plants of the family Rosaceae such as loquat, waremokou, nobara, hawthorn, Clover, eucalyptus, allspice, bunjiro, teninka, guava and other turmeric are used as plants of the family Myrtaceae, such as apples.
When using these plants, it is preferable to use a lower alcohol in combination.
[0022]
As the medicinal component composition, known components such as vitamin E, vitamin C, sodium chloride, and hinokitiol can be blended based on the purpose of use.
[0023]
【Example】
Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited to the examples.
The amounts of the compositions used indicate weight%.
[0024]
Example 1
Lactic acid bacteria symbiotic culture extract 0.7 (%)
Citric acid 0.2
Sodium citrate 1.5
Sodium benzoate 0.2
Xylitol 7.0
Glycerin 5.0
Ethanol 5.0
Polyoxyethylene hardened castor oil 1.5
Peppermint oil 0.3
Purified water remaining 100.0
[0025]
Example 2
Aloe extract 0.8 (%)
Citric acid 0.2
Sodium citrate 1.5
Sodium benzoate 0.2
Xylitol 7.0
Glycerin 5.0
Ethanol 5.0
Polyoxyethylene hardened castor oil 1.5
Peppermint oil 0.3
Purified water remaining 100.0
[0026]
Example 3
Artemisia extract 0.8 (%)
Citric acid 0.2
Sodium citrate 1.5
Sodium benzoate 0.2
Xylitol 7.0
Glycerin 5.0
Ethanol 5.0
Polyoxyethylene hardened castor oil 1.5
Peppermint oil 0.3
Purified water remaining 100.0
[0027]
Example 4
Aloe extract 0.5 (%)
Artemisia extract 0.5
Citric acid 0.2
Sodium citrate 1.5
Sodium benzoate 0.2
Xylitol 7.0
Glycerin 5.0
Ethanol 5.0
Polyoxyethylene hardened castor oil 1.5
Peppermint oil 0.3
Purified water remaining 100.0
[0028]
Example 5
Lactic acid bacteria symbiotic culture extract 0.5 (%)
Artemisia extract 0.5
Citric acid 0.2
Sodium citrate 1.5
Sodium benzoate 0.2
Xylitol 7.0
Glycerin 5.0
Ethanol 5.0
Polyoxyethylene hardened castor oil 1.5
Peppermint oil 0.3
Purified water remaining 100.0
[0029]
Example 6
Lactic acid bacteria symbiotic culture extract 0.5 (%)
Aloe extract 0.5
Citric acid 0.2
Sodium citrate 1.5
Sodium benzoate 0.2
Xylitol 7.0
Glycerin 5.0
Ethanol 5.0
Polyoxyethylene hardened castor oil 1.5
Peppermint oil 0.3
Purified water remaining 100.0
[0030]
Example 7
Lactic acid bacteria symbiotic culture extract Aloe extract 0.5 (%)
Artemisia extract 0.5
Citric acid 0.2
Sodium citrate 1.5
Sodium benzoate 0.2
Xylitol 7.0
Glycerin 5.0
Ethanol 5.0
Polyoxyethylene hardened castor oil 1.5
Peppermint oil 0.3
Purified water remaining 100.0
[0031]
Example 8
Lactic acid bacteria symbiotic culture extract 1 (%)
Sodium bicarbonate 20
Sorbitol 14
Glycerin 8
Sodium chloride 15
CMC 1.5
Sodium lauryl sulfate 2
Saccharin sodium 0.1
Aluminum hydroxide 20
Fragrance 0.8
Purified water residue [0032]
Example 9
Lactic acid bacteria symbiotic culture extract 0.5 (%)
Aloe extract 0.5
Sodium bicarbonate 20
Sorbitol 14
Glycerin 8
Sodium chloride 15
CMC 1.5
Sodium lauryl sulfate 2
Saccharin sodium 0.1
Aluminum hydroxide 20
β-glycyrrhetinic acid 0.01
Fragrance 0.8
Purified water residue [0033]
Example 10
Lactic acid bacteria symbiotic culture extract 0.5 (%)
Artemisia extract 0.5
Sodium bicarbonate 30
Silicic anhydride 6
Sorbitol 15
Sodium chloride 15
CMC 1.5
Sodium lauryl sulfate 2.5
Saccharin sodium 0.3
Sodium chloride 1.5
β-glycyrrhetinic acid 0.01
Fragrance 0.8
Purified water residue [0034]
Example 11
Lactic acid bacteria symbiotic culture extract 0.5 (%)
Aloe extract 0.5
Artemisia extract 0.5
Ethanol 10.0
Polyoxyethylene (60) hardened castor oil 2.0
Xylitol 7.0
Glycerin 3.0
Sodium benzoate 0.2
β-cyclodextrin 0.02
Benzethonium chloride 0.005
Fragrance 0.2
Purified water remaining 100.0
[0035]
Example 12
Lactic acid bacteria symbiotic culture extract 0.5 (%)
Aloe extract 0.5
Artemisia extract 0.5
Ethanol 45.0 (%)
Glycerin 10.0
Polyoxyethylene (40) hardened castor oil 2.5
Benzalkonium chloride 0.001
Xylitol 3.0
Fragrance 0.5
Purified water remaining 100.0
[0036]
EFFECTS OF THE INVENTION The lactic acid bacteria co-cultivated extract of the present invention reduces the bitter component due to the foaming agent or various surfactants, and also has a cleaning and washing effect by the comprehensive action of the aloe component, and hemostasis due to the mugwort component. -Remarkable biologically-friendly clinical effects of herbal ingredients, such as improving and enhancing the gingival tightening effect, were confirmed. In particular, the effect of the lactic acid bacteria coexisting culture extract on bitterness was remarkable. Since the oral composition of the present invention contains a large amount of mucopolysaccharide, aloecin, enzymes, aloenin, aloetin, saponin and the like as components, the aloe extract and / or powder has a bactericidal action, an antifungal action and It can exert anti-inflammatory action.
The mugwort extract and / or powder can exhibit blood circulation disorder, prevention and improvement of alveolar pyorrhea, and blood purification / disinfection and hemostatic action.
Lactic acid bacterium co-cultivation extract has clinically exhibited many medicinal effects, for example, remarkable therapeutic or pharmacological effects such as blood purification, antibacterial and bactericidal effects, and further synergistic effects by using these components in combination. Can be obtained.
Due to the synergistic effect of these various components that exhibit excellent medicinal properties, various or hundreds of millions of various fungi in the oral cavity are killed, prevention of cavities and prevention or treatment of all periodontal diseases such as periodontitis. In addition, it is possible to obtain an unexpected excellent and remarkable effect on inflammation of teeth and the like.
The present invention further provides a liquid oral composition for periodontitis and bad breath, prevention and treatment by mixing a liquid lactic acid bacteria co-cultivation extract, a liquid mugwort extract and / or a liquid aloe extract as follows. Can be.
For conventional oral compositions, various aloe containing various medicinal components, the effect of adding a lactic acid bacteria co-cultivation extract to mugworts is often more remarkable than conventional medicated toothpaste. Clinically confirmed at a dental clinic.

Claims (4)

An oral composition comprising a lactic acid bacteria co-cultivation extract and / or an aloe extract and / or a mugwort extract and / or a mushroom extract. The oral composition according to claim 1, wherein the aloe extract is an aloe vera extract. The oral composition according to claim 1 or 2, wherein the mushroom is agaricus. The oral composition according to any one of claims 1 to 3, further comprising at least one of an abrasive, a wetting agent, a flavoring agent, a foaming agent, a binder, a preservative, and a cleaning agent.