CN103445980A - Paeonol tooth protection toothpaste - Google Patents
Paeonol tooth protection toothpaste Download PDFInfo
- Publication number
- CN103445980A CN103445980A CN2013103747093A CN201310374709A CN103445980A CN 103445980 A CN103445980 A CN 103445980A CN 2013103747093 A CN2013103747093 A CN 2013103747093A CN 201310374709 A CN201310374709 A CN 201310374709A CN 103445980 A CN103445980 A CN 103445980A
- Authority
- CN
- China
- Prior art keywords
- paeonol
- tooth
- toothpaste
- whitening agent
- caring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 title claims abstract description 78
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 title claims abstract description 39
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 38
- 239000000606 toothpaste Substances 0.000 title claims abstract description 38
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 31
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 11
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims abstract description 11
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 11
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims abstract description 11
- 229940038472 dicalcium phosphate Drugs 0.000 claims abstract description 11
- 229910000390 dicalcium phosphate Inorganic materials 0.000 claims abstract description 11
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920000609 methyl cellulose Polymers 0.000 claims abstract description 11
- 239000001923 methylcellulose Substances 0.000 claims abstract description 11
- 239000000600 sorbitol Substances 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000811 xylitol Substances 0.000 claims abstract description 11
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 11
- 229960002675 xylitol Drugs 0.000 claims abstract description 11
- 235000010447 xylitol Nutrition 0.000 claims abstract description 11
- 230000002087 whitening effect Effects 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 14
- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 claims description 10
- 244000060011 Cocos nucifera Species 0.000 claims description 10
- 235000013162 Cocos nucifera Nutrition 0.000 claims description 10
- BKDZVPVJIXZYBH-UHFFFAOYSA-N [Na].C(C)(=O)O.NC(=N)N Chemical compound [Na].C(C)(=O)O.NC(=N)N BKDZVPVJIXZYBH-UHFFFAOYSA-N 0.000 claims description 10
- 125000002252 acyl group Chemical group 0.000 claims description 10
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 10
- 108010015776 Glucose oxidase Proteins 0.000 claims description 9
- 235000019420 glucose oxidase Nutrition 0.000 claims description 9
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 7
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims description 6
- CPUHNROBVJNNPW-UHFFFAOYSA-N aloin A Natural products OC1C(O)C(O)C(CO)OC1OC1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 CPUHNROBVJNNPW-UHFFFAOYSA-N 0.000 claims description 6
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 6
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 6
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 6
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 claims description 6
- 229940083982 sodium phytate Drugs 0.000 claims description 6
- 239000004366 Glucose oxidase Substances 0.000 claims description 5
- 239000004378 Glycyrrhizin Substances 0.000 claims description 5
- 229940116332 glucose oxidase Drugs 0.000 claims description 5
- AFHJQYHRLPMKHU-WEZNYRQKSA-N aloin B Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-WEZNYRQKSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 3
- 239000006260 foam Substances 0.000 abstract description 2
- 208000007565 gingivitis Diseases 0.000 abstract description 2
- 201000001245 periodontitis Diseases 0.000 abstract description 2
- GLSRFBDXBWZNLH-UHFFFAOYSA-L disodium;2-chloroacetate;2-(4,5-dihydroimidazol-1-yl)ethanol;hydroxide Chemical compound [OH-].[Na+].[Na+].[O-]C(=O)CCl.OCCN1CCN=C1 GLSRFBDXBWZNLH-UHFFFAOYSA-L 0.000 abstract 1
- 229940096501 sodium cocoamphoacetate Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 description 8
- AFHJQYHRLPMKHU-OSYMLPPYSA-N aloin A Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-OSYMLPPYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- AFHJQYHRLPMKHU-CGISPIQUSA-N aloin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-CGISPIQUSA-N 0.000 description 4
- 235000002949 phytic acid Nutrition 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- -1 sodium phytates Chemical class 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- 230000000680 avirulence Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- KETSPIPODMGOEJ-UHFFFAOYSA-B dodecasodium;(2,3,4,5,6-pentaphosphonatooxycyclohexyl) phosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OC1C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C1OP([O-])([O-])=O KETSPIPODMGOEJ-UHFFFAOYSA-B 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- 239000011344 liquid material Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000013077 scoring method Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The invention relates to paeonol tooth protection toothpaste. The paeonol tooth protection toothpaste comprises the following components in percentage by weight: 0.2 to 0.6% of paeonol, 16 to 20% of glycerinum, 10 to 14% of sorbitol, 1.1 to 1.3% of methylcellulose, 1.8 to 2.2% of sodium cocoamphoacetate, 0.2 to 0.4% of xylitol, 40 to 50% of dicalcium phosphate dehydrate and the balance of water. The paeonol tooth protection toothpaste is rich in foam and fresh in taste and has certain curative effect on periodontitis and gingivitis.
Description
Technical field
The present invention relates to a kind of toothpaste, be specifically related to a kind of paeonol tooth-caring toothpaste.
Background technology
Toothpaste is to be used from cleaning teeth with toothbrush one, and the protection oral hygiene, to a kind of daily necessities of human-body safety.Along with the raising of people's living standard, to the also progressively raising of quality requirement of toothpaste.At aspect of performance General Requirements toothpaste: (1) can remove the thin film of dental surface and bacterial plaque and not damage enamel and dentin; (2) there is good cleaning oral cavity and effect on every side thereof; (3) avirulence, non-stimulated to oral mucosa; (4) comfortable fragrance and taste are arranged, cool and sweet-smelling sensation is arranged after use.
Summary of the invention
For above shortcomings in prior art, technical problem to be solved by this invention is to provide a kind of paeonol tooth-caring toothpaste.
The present invention seeks to be achieved through the following technical solutions:
A kind of paeonol tooth-caring toothpaste is comprised of following compositions in weight percentage: 0.2-0.6% paeonol, 16-20% glycerol, the 10-14% sorbitol, 1.1-1.3% methylcellulose, 1.8-2.2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, the 0.2-0.4% xylitol, the 40-50% dicalcium phosphate dehydrate, surplus is water.
Preferably,
A kind of paeonol tooth-caring toothpaste, by following compositions in weight percentage, formed: the 0.2-0.6% paeonol, 16-20% glycerol, the 10-14% sorbitol, 1.1-1.3% methylcellulose, 1.8-2.2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, the 0.2-0.4% xylitol, the 40-50% dicalcium phosphate dehydrate, the 1-3% whitening agent, surplus is water.
Described whitening agent is a kind of or its mixture in sodium phytate, aloin, glycyrrhizin and glucoseoxidase.
Best, described whitening agent consists of by weight following component: 40-60 part sodium phytate, 10-20 part aloin, 10-20 part glycyrrhizin and 15-25 part glucoseoxidase.
In the present invention,
Sodium phytate, English name: Sodium phytate, CAS accession number: 14306-25-3.
Aloin, English name: Aloin, CAS accession number: 5133-19-7.
Glycyrrhizin, English name: Glycyrrhizic acid, CAS accession number: 1405-86-3.
Glucoseoxidase, No. CAS: 9001-37-0, name of commodity in English: EC1.1.3.4, EINECS:232-601-0.
Compared with prior art, paeonol tooth-caring toothpaste foam of the present invention is abundant, and mouthfeel delicate fragrance, have certain curative effect to periodontitis, gingivitis etc.
The specific embodiment
Embodiment 1
A kind of paeonol tooth-caring toothpaste is comprised of following compositions in weight percentage: 0.4% paeonol, and 18% glycerol, 12% sorbitol, 1.2% methylcellulose, 2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, 0.3% xylitol, 45% dicalcium phosphate dehydrate, 2% whitening agent, surplus is water.
Described whitening agent consists of by weight following component: 50 parts of sodium phytates, 15 parts of aloins, 15 parts of glycyrrhizins and 20 parts of glucoseoxidases.
Paeonol tooth-caring toothpaste of the present invention can adopt the conventional method preparation of this area fully, as " detergent compositions workshop manual ", (Xu Baocai etc. write, Chemical Industry Press, chemistry and applied chemistry publishing centre, January in 2006 the 1st edition) the disclosed toothpaste production technology of 594-597 page is prepared.Concrete, the preparation method of the present embodiment paeonol tooth-caring toothpaste is: after the above-mentioned raw materials component is weighed, disperse in pre-dispersed still, mix, open cream still vacuum pump processed and suck above-mentioned liquid material, then open scraper, agitator and colloid mill, close colloid mill, agitator and scraper successively after 50 minutes, vacuum breaker, obtain the paeonol tooth-caring toothpaste.
Obviously, the preparation method of toothpaste is prior art in the present invention, does not have special character, and main improvement of the present invention just is the difference of formula.
Embodiment 2
A kind of paeonol tooth-caring toothpaste is comprised of following compositions in weight percentage: 0.4% paeonol, and 18% glycerol, 12% sorbitol, 1.2% methylcellulose, 2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, 0.3% xylitol, 45% dicalcium phosphate dehydrate, 2% whitening agent, surplus is water.
Described whitening agent consists of by weight following component: 50 parts of sodium phytates, 15 parts of aloins and 20 parts of glucoseoxidases.
According to the preparation method of embodiment 1, obtain the paeonol tooth-caring toothpaste of embodiment 2.
Embodiment 3
A kind of paeonol tooth-caring toothpaste is comprised of following compositions in weight percentage: 0.4% paeonol, and 18% glycerol, 12% sorbitol, 1.2% methylcellulose, 2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, 0.3% xylitol, 45% dicalcium phosphate dehydrate, 2% whitening agent, surplus is water.
Described whitening agent consists of by weight following component: 50 parts of sodium phytates, 15 parts of glycyrrhizins and 20 parts of glucoseoxidases.
According to the preparation method of embodiment 1, obtain the paeonol tooth-caring toothpaste of embodiment 3.
Embodiment 4
A kind of paeonol tooth-caring toothpaste is comprised of following compositions in weight percentage: 0.4% paeonol, and 18% glycerol, 12% sorbitol, 1.2% methylcellulose, 2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, 0.3% xylitol, 45% dicalcium phosphate dehydrate, 2% whitening agent, surplus is water.
Described whitening agent consists of by weight following component: 50 parts of sodium phytates, 15 parts of aloins and 15 parts of glycyrrhizins.
According to the preparation method of embodiment 1, obtain the paeonol tooth-caring toothpaste of embodiment 4.
Embodiment 5
A kind of paeonol tooth-caring toothpaste is comprised of following compositions in weight percentage: 0.4% paeonol, and 18% glycerol, 12% sorbitol, 1.2% methylcellulose, 2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, 0.3% xylitol, 45% dicalcium phosphate dehydrate, 2% whitening agent, surplus is water.
Described whitening agent consists of by weight following component: 15 parts of aloins, 15 parts of glycyrrhizins and 20 parts of glucoseoxidases.
According to the preparation method of embodiment 1, obtain the paeonol tooth-caring toothpaste of embodiment 5.
Embodiment 6
A kind of paeonol tooth-caring toothpaste is comprised of following compositions in weight percentage: 0.4% paeonol, and 18% glycerol, 12% sorbitol, 1.2% methylcellulose, 2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, 0.3% xylitol, 45% dicalcium phosphate dehydrate, surplus is water.
According to the preparation method of embodiment 1, obtain the paeonol tooth-caring toothpaste of embodiment 6.
Test case
48 adult men and women are divided into to 6 groups, use embodiment 1-5 toothpaste, every day, each was brushed once sooner or later, to reaching the mottle index LSI of use after 3 months continuously before using, tested respectively, method of testing and scoring rule are permitted first 5th～6 pages of 1.4.1 of master thesis " a kind of clinical efficacy evaluation study of novel whitening toothpaste " of son referring to Shanghai Communications University.
The LSI scoring method, concrete scoring rule is as follows:
0 minute-without mottle, exist;
1 minute-mottle size is no more than 1/3 of facing; Degree is slight mottle (yellow or yellowish-brown);
2 minutes-mottle size is no more than 2/3 of facing; Degree is moderate mottle (moderate brown);
3 minutes-mottle size is greater than 2/3 of facing; Degree is severe mottle (dark-brown or black).
LSI value after the statistics experimenter uses front LSI value and uses March, LSI meansigma methods after calculating the front LSI meansigma methods of use and using March, then calculate mottle index LSI rate of descent, the results are shown in Table 1.
Table 1: mottle index LSI test chart
| ? | Mottle index LSI rate of descent, % |
| Embodiment 1 | 32.3 |
| Embodiment 2 | 31.2 |
| Embodiment 3 | 31.4 |
| Embodiment 4 | 28.5 |
| Embodiment 5 | 26.7 |
| Embodiment 6 | 14.8 |
Mottle index LSI rate of descent (%)=[LSI meansigma methods before using-uses is the LSI meansigma methods after March]/use front LSI meansigma methods * 100%.
As seen from the data in Table 1, using embodiment 1-5 toothpaste after 3 months, the obvious decline of LSI value, toothpaste of the present invention has whitening effect preferably.
Claims (4)
1. a paeonol tooth-caring toothpaste, it is characterized in that, by following compositions in weight percentage, formed: the 0.2-0.6% paeonol, 16-20% glycerol, 10-14% sorbitol, 1.1-1.3% methylcellulose, 1.8-2.2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, the 0.2-0.4% xylitol, the 40-50% dicalcium phosphate dehydrate, surplus is water.
2. a paeonol tooth-caring toothpaste, it is characterized in that, by following compositions in weight percentage, formed: 0.2-0.6% paeonol, 16-20% glycerol, 10-14% sorbitol, the 1.1-1.3% methylcellulose, 1.8-2.2% cocos nucifera oil acyl both sexes guanidine-acetic acid sodium, 0.2-0.4% xylitol, 40-50% dicalcium phosphate dehydrate, the 1-3% whitening agent, surplus is water.
3. paeonol tooth-caring toothpaste as claimed in claim 2, it is characterized in that: described whitening agent is a kind of or its mixture in sodium phytate, aloin, glycyrrhizin and glucoseoxidase.
4. paeonol tooth-caring toothpaste as claimed in claim 3, is characterized in that, described whitening agent consists of by weight following component: 40-60 part sodium phytate, 10-20 part aloin, 10-20 part glycyrrhizin and 15-25 part glucoseoxidase.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310374709.3A CN103445980B (en) | 2013-08-24 | 2013-08-24 | Paeonol tooth protection toothpaste |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310374709.3A CN103445980B (en) | 2013-08-24 | 2013-08-24 | Paeonol tooth protection toothpaste |
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| CN103445980A true CN103445980A (en) | 2013-12-18 |
| CN103445980B CN103445980B (en) | 2016-03-02 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022062300A1 (en) * | 2020-09-23 | 2022-03-31 | Shandong Benzhen Cosmetics Co., Ltd | Surfactant-free foamable oral care composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380285A (en) * | 2008-09-26 | 2009-03-11 | 中华全国供销合作总社南京野生植物综合利用研究院 | Bletilla striata Chinese herbal medicine toothpaste |
| CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN102178614A (en) * | 2011-04-07 | 2011-09-14 | 杭州皎洁口腔保健用品有限公司 | Compound Chinese herbal medicine toothpaste and preparation method of same |
-
2013
- 2013-08-24 CN CN201310374709.3A patent/CN103445980B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101380285A (en) * | 2008-09-26 | 2009-03-11 | 中华全国供销合作总社南京野生植物综合利用研究院 | Bletilla striata Chinese herbal medicine toothpaste |
| CN101766551A (en) * | 2010-03-30 | 2010-07-07 | 天津天狮生物发展有限公司 | Drug toothpaste for treating oral diseases and preparation method thereof |
| CN102178614A (en) * | 2011-04-07 | 2011-09-14 | 杭州皎洁口腔保健用品有限公司 | Compound Chinese herbal medicine toothpaste and preparation method of same |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022062300A1 (en) * | 2020-09-23 | 2022-03-31 | Shandong Benzhen Cosmetics Co., Ltd | Surfactant-free foamable oral care composition |
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| CN103445980B (en) | 2016-03-02 |
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Inventor after: Deng Xuefeng Inventor before: Song Fanhua |
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