CN103536482A - Application of caulis sinomenii extract and radix sanguisorbae extract in preparing oral care product - Google Patents
Application of caulis sinomenii extract and radix sanguisorbae extract in preparing oral care product Download PDFInfo
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Abstract
The invention discloses application of a caulis sinomenii extract and a radix sanguisorbae extract in preparing an oral care product, namely adding the caulis sinomenii extract and radix sanguisorbae extract into an oral care product in a compound manner in a technology of preparing an oral care product, wherein the caulis sinomenii extract and radix sanguisorbae extract are used as active components for easing pain and preventing gum bleeding. Compared with the prior art, the caulis sinomenii extract and radix sanguisorbae extract have a remarkable effect in preventing toothache and gum bleeding.
Description
Technical field
The present invention relates to oral care implement technical field, especially a kind of Caulis Sinomenii extract and the application of Radix Sangusorbae extract in preparing oral care product.
Background technology
The conventional oral care product of people is mainly toothpaste, collutory, dentifrice etc., and its basic function is exactly cleaning teeth, and protection gingiva, safeguards the hygiene and health in oral cavity.Raising along with people's living standard, the health care consciousness of consumer constantly strengthens, oral care product has also been proposed to more requirement, people have also increased some except having this basic function that cleans the teeth to the requirement of toothpaste and collutory can assist the effect of prevention oral disease, therefore, toothpaste in the market and collutory almost all add the functional component for the various oral diseases of control, therefore the product that oral care product both domestic and external has various functional types has become the market mainstream, is wherein to add western medicine composition to realize mostly.
But along with economic development, be accompanied by day by day manifesting of the problems such as environmental pollution, ecological disturbance, consumer more and more pays close attention to the safety of product, thereby more and more advocates natural and safe product.Interpolation can effectively prevent and treat the oral care product of various oral disease Chinese herbal medicine, little with its toxic and side effects, features such as green, environmental protection, safety height and be doubly subject to people's favor, and on market, the consumption demand of this series products is in continuous growth.In addition, along with the development of modernization of Chinese medicine technology, the method for Chinese medicine study of active components utilization has also been obtained to fine development, this assists prevention oral disease that good technical support is provided for oral care product utilizes active ingredient of Chinese herbs.
Toothache is the oral disease being caused by many reasons, according to interrelated data, shows, China has the consumer surpassing more than 50% to have toothache in various degree at different times.Gingival hemorrhage is also one of department of stomatology common sympton, refers to that gingiva is idiopathic or due to bleeding on a small quantity that minimal irritation causes.The lighter only shows as sucking, brush teeth, while chewing harder food in saliva with the blood streak, severe one is hemorrhage more even hematostaxis when gingiva is subject to minimal irritation.Generally speaking, the chronic inflammatory disease of gingiva is the common cause of gingival hemorrhage, therefore gingival hemorrhage is more common in periodontitis and gingivitis patients.According to interrelated data, show, due to bad dietary habit and think little of oral hygiene, at different times, there is gingival hemorrhage in various degree in increasing crowd, for this reason, be necessary to comply with the needs of market development, the Chinese herbal medicine extract safely and effectively of usining is developed the oral care product of a kind of special control toothache and gingival hemorrhage as active component.
Summary of the invention
The problem that the present invention solves is to provide Caulis Sinomenii extract and the application scheme of Radix Sangusorbae extract in preparing oral care product, and this oral cavity nursing health products has obvious analgesia and anastalsis.
Caulis Sinomenii extract of the present invention and the Radix Sangusorbae extract application scheme in preparing oral care product be exactly in preparing the technique of oral care implement the active component using Caulis Sinomenii extract and Radix Sangusorbae extract as analgesia and anastalsis join in the oral care products such as toothpaste, collutory, dentifrice, throat lozenge and chewing gum.
In technique scheme, scheme can also be more specifically: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing toothpaste technique.
Further: the percentage by weight in total mastic of toothpaste is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and described Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
Further: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing collutory technique.
Further: the percentage by weight in collutory raw material is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
Further: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing dentifrice technique.
Further: the percentage by weight in dentifrice raw material is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
Further: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing throat lozenge technique.
Further: the percentage by weight in throat lozenge raw material is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
Further: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing chewing gum technique.
Further: the percentage by weight in chewing-gum material is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
The said Caulis Sinomenii of the present invention is the dry rattan of menispermaceous plants Sinomenium acutum Sinomenium acutum (Thunb.) Rehd. et Wils. and hair Sinomenium acutum Sinomenium acutum (Thunb.) Rehd. et Wils. var. cinereum Rehd. et Wils., nature and flavor are bitter, pungent, flat, return liver, spleen channel, its major function is Eradicates rheumatism, the meridian dredging, diuresis, pain relieving, can be used for rheumatic arthralgia, arthroncus, paralysis pruritus and pain relieving etc.
The said Radix Sanguisorbae of the present invention is the dry root of rosaceous plant Radix Sanguisorbae Sanguisorba officinalis L. or Radix Sanguisorbae Sanguisorba officinalis L. var. longifolia (Bert.) the Y ü et Li that comes into leaves.Major function cooling blood for hemostasis, heat-clearing and toxic substances removing, detumescence sore.
The extracting method of Caulis Sinomenii extract of the present invention and Radix Sangusorbae extract be by the former medicine of the extract of Caulis Sinomenii and Radix Sanguisorbae in the ratio of 10:3 respectively scale go out, again every taste Chinese medicine is broken into granularity, with the alcohol heating reflux of 10 times of amounts, extract 3 hours, extract 3 times, then extracting solution concentrating under reduced pressure is become to extractum or is dried to powdery; Extracting method is not limited to said method, also can adopt the additive methods such as supercritical extraction, ultrasonic extraction to extract; Also can use existing commercially available Chinese medicine extract.
It is example that the content of the Caulis Sinomenii extract described in the present invention and Radix Sangusorbae extract all be take the pure extract powder that active component is 100%, but is not limited to pure extract powder, can be also other forms such as extracting solution or extractum.When being applied to oral care product with other forms as extracting solution, the addition in formula should be converted to the amount of disclosed pure form of extract in the present invention.
Oral care implement of the present invention adds Caulis Sinomenii extract and Radix Sangusorbae extract as natural plant active component, to have the effect of significant control toothache and gingival hemorrhage in preparation process.
The present invention, to the oral cavity composition containing herbal mixture, more specifically, carries out the analgesic activity (hot plate method) to white mice to the toothpaste containing compound extract, makes positive control and blank simultaneously and observes.Experimental result shows, this herbal mixture toothpaste and positive control medicine diclofenac diethylammonium group, with the comparison of blank group, all can significantly improve the pain threshold of white mice, there is obvious analgesic activity, there were significant differences statistically, shows that this herbal mixture toothpaste has significant analgesic activity.
The present invention, to carry out the anastalsis experiment of laboratory animal white rabbit liver local woanded surface bleeding due to trauma containing this herbal mixture toothpaste, makes positive control and blank simultaneously and observes.Experimental result shows, this herbal mixture toothpaste and positive control medicine YUNNAN BAIYAO, with the comparison of blank group, all have obvious anastalsis to rabbit liver local woanded surface bleeding due to trauma, there were significant differences statistically, shows that this herbal mixture toothpaste has significant anastalsis.
The specific embodiment
Below in conjunction with specific embodiment, the present invention will be further described; In following each embodiment, related percentage ratio except as otherwise noted, is all to calculate by weight percentage.
Embodiment 1-5: Caulis Sinomenii extract and Radix Sangusorbae extract be the application in toothpaste as compound Chinese medicine extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3.
The toothpaste constitutive material of embodiment 1-5 and weight percent content are as following table:
The preparation method of toothpaste in embodiment 2:
Lotion of toothpaste can adopt the one-step method of conventional medicine toothpaste cream production technology processed to make: the liquid materials such as the pure water that input measures in temporary cylinder, sorbitol, Radix Sangusorbae extract, Caulis Sinomenii extract; In pre-dispersed still, drop into the calcite in powder, saccharin sodium, sodium carboxymethyl cellulose, sodium lauryl sulphate, the nipalgin that measure and mix the powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Then open scraper, enter above-mentioned powder, drive agitator and colloid mill, after 50 minutes, drop into essence, close successively colloid mill, agitator, scraper after 10 minutes, vacuum breaker, stops vacuum pump, after sampling detection is qualified, makes.
Embodiment 1, embodiment 3-5 production technology are with reference to embodiment 1.
Embodiment 6-10: Caulis Sinomenii extract and Radix Sangusorbae extract be the application in collutory as compound Chinese medicine extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3.
The collutory constitutive material of embodiment 6-10 and weight percent content are as following table:
The preparation method of collutory in embodiment 8:
First Caulis Sinomenii extract, Radix Sangusorbae extract, nipalgin mixed ester sodium are added stirring and dissolving in food grade ethanol to be placed in temporary pot, sorbitol, deionized water, castor oil hydrogenated-40 are added in agitated kettle and stirred 10 minutes, alcoholic solution in temporary pot is added in agitated kettle and stirred 10 minutes, finally add essence to stir 5 minutes, stop stirring, after sampling detection is qualified, make.
Embodiment 6-7, embodiment 9-10 production technology are with reference to embodiment 8.
Embodiment 11-15: Caulis Sinomenii extract and Radix Sangusorbae extract be the application in dentifrice as compound Chinese medicine extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3.
The dentifrice constitutive material of embodiment 11-15 and weight percent content are as following table:
The preparation method of dentifrice in embodiment 14:
After natural whiting, sodium carboxymethyl cellulose, sodium lauryl sulphate, saccharin sodium are weighed up by formula consumption, add in mixing agitator and stir after 20 minutes and add compound Chinese medicine extract to stir 10 minutes; finally add essence, sorbitol to stir after 20 minutes and shut down, after sampling detection is qualified, make.
The preparation method of dentifrice in embodiment 15: add in mixing agitator and stir after 20 minutes after calcium phosphate dibasic dihydrate, silicon dioxide, sodium carboxymethyl cellulose, saccharin sodium, sodium lauryl sulphate, nipalgin mixed ester sodium are weighed up by formula consumption; add compound Chinese medicine extract to stir 10 minutes; finally add essence, sorbitol to stir after 20 minutes and shut down, after sampling detection is qualified, make.
Embodiment 11-13 production technology is with reference to embodiment 14-15.
Embodiment 16-20: Caulis Sinomenii extract and Radix Sangusorbae extract be the application in throat lozenge as compound Chinese medicine extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3.
The throat lozenge constitutive material of embodiment 16-20 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing throat lozenge production technology.
Embodiment 21-25: Caulis Sinomenii extract and Radix Sangusorbae extract be the application in chewing gum as compound Chinese medicine extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3.
The chewing gum constitutive material of embodiment 21-25 and weight percent content are as following table:
The preparation technology of above-described embodiment adopts existing chewing gum production technology.
clinical trial part:
The analgesic activity pharmacological experiment of compound Chinese medicine extract toothpaste:
Contain compound Chinese medicine extract toothpaste sample to the analgesic activity of white mice (hot plate method); Choose the healthy Kunming of body weight 18～22g kind ♀ white mice, with GJ-8402 type hot plate dolorimeter, regulate and control temperature at 55 ± 0.5 ℃, white mice is placed on to the pain threshold (white mice contact hot plate is to the time of licking metapedes) of measuring every Mus on hot plate, allly lick the metapedes time and be less than 5 seconds (S) or be greater than 30 seconds (S) and leaper gives it up, select 40 of qualified white mice, divide equally at random 4 groups, 10 every group.Blank group, the blank matrix group of toothpaste, positive drug diclofenac diethylamine emulgel group, herbal mixture toothpaste sample group.Each organizes the normal pain threshold that white mice repeats to measure for 2 times white mice by the same method, and every minor tick 15min, gets two subnormal pain threshold meansigma methodss, as the pain threshold before this group white mice administration.Respectively at 4 sufficient sole of the foots of the every Mus of each treated animal, be coated with and only give corresponding tested material 0.2g/, blank group is coated with only gives normal saline 0.2ml/, painting is given 15min, 30min after tested material, 45min and is measured respectively by the same method the pain threshold of white mice, as still reactionless in white mice 60 seconds (S), white mice is taken out, in order to avoid scald, its pain threshold calculates with 60 seconds (s), white mice pain threshold respectively organized in record, and data are carried out statistics t check, the results are shown in Table 1:
Experimental result shows, the front and blank group comparison with administration containing compound Chinese medicine extract toothpaste sample group and diclofenac diethylamine emulgel group, all can significantly improve white mice pain threshold; Containing compound Chinese medicine extract toothpaste sample group and the blank matrix group comparison of toothpaste, can significantly improve white mice pain threshold, show to there is obvious analgesic activity containing compound Chinese medicine extract toothpaste sample group.
The anastalsis pharmacological experiment of compound Chinese medicine extract toothpaste:
Get 55 of healthy white rabbit, body weight 2.0～2.5kg, male and female dual-purpose.With 3% pentobarbital sodium 30mg/kg auricular vein, slowly inject, after family's rabbit anesthesia, lie on the back and be fixed on operating-table, abdominal part median incision is about 6～8cm, and exposure fixedly liver, cut liver organization with operating scissors at leftlobe of liver and be about 1cm, wide about 1cm, high about 1cm, it is hemorrhage that wound surface is injection sample.Wipe after the blood of ejection, at the local spreading of wound surface matter sample 1g to be tried, gauze is topped immediately, with 200g counterweight compressing 1min, after 1min, remove counterweight, observe haemostatic effect, take not hemorrhage is hemostasis, as still hemorrhage, add spreading and after trying matter sample, continue pressurization, every 30s, observe once, record bleeding stopping period, as still hemorrhage in surpassed 3min, be designated as and fail to stop blooding, bleeding stopping period is designated as > 3min.After each sample test, with 37 ℃ of normal saline, wash away residual tested material, make wound surface again hemorrhage, then test next tested material sample.Every rabbit carries out liver local woanded surface damage hemostasis test experiments four times, and each tested material sample is pressed the drug of topical application of Latin square program, to reduce the impact of liver local woanded surface damage otch difference and medication order.Blank group, the blank matrix group of toothpaste, positive drug YUNNAN BAIYAO group, Radix Sanguisorbae toothpaste sample group.Each tested material sample amounts to the hemostasis experiment of carrying out 20 rabbit liver local woanded surface bleeding due to traumies.Haemostatic effect is designated as score value F by scoring method reciprocal (10/T), and 3min fails to stop blooding above, and F is designated as 0 without score value.Record and carry out statistics t check, the results are shown in Table 2:
Experimental result shows, herbal mixture toothpaste sample group and YUNNAN BAIYAO group all have obvious haemostatic effect to rabbit liver local woanded surface bleeding due to trauma, show that herbal mixture toothpaste sample group and YUNNAN BAIYAO group have obvious anastalsis,
conclusion:sample sets containing Caulis Sinomenii and Radix Sanguisorbae two taste compound Chinese medicine extract toothpaste can significantly improve white mice pain threshold, there is obvious analgesic activity, containing Caulis Sinomenii and Radix Sanguisorbae two taste compound Chinese medicine extract toothpaste sample groups, rabbit liver local woanded surface bleeding due to trauma is all had to obvious haemostatic effect, there is obvious anastalsis.
Claims (11)
1. Caulis Sinomenii extract and the Radix Sangusorbae extract application in preparing oral care product, the form of compound recipe of in preparing the technique of oral care implement, Caulis Sinomenii extract and Radix Sangusorbae extract being usingd adds in oral care product as the active component of analgesia and control gingival hemorrhage.
2. Caulis Sinomenii extract according to claim 1 and the Radix Sangusorbae extract application in preparing oral care product, is characterized in that: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing toothpaste technique.
3. Caulis Sinomenii extract according to claim 2 and the Radix Sangusorbae extract application in preparing oral care product, it is characterized in that: the percentage by weight in total mastic of toothpaste is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and described Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
4. Caulis Sinomenii extract according to claim 1 and the Radix Sangusorbae extract application in preparing oral care product, is characterized in that: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing collutory technique.
5. Caulis Sinomenii extract according to claim 4 and the Radix Sangusorbae extract application in preparing oral care product, it is characterized in that: the percentage by weight in collutory raw material is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
6. Caulis Sinomenii extract according to claim 1 and the Radix Sangusorbae extract application in preparing oral care product, is characterized in that: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing dentifrice technique.
7. Caulis Sinomenii extract according to claim 6 and the Radix Sangusorbae extract application in preparing oral care product, it is characterized in that: the percentage by weight in dentifrice raw material is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
8. Caulis Sinomenii extract according to claim 1 and the Radix Sangusorbae extract application in preparing oral care product, is characterized in that: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing throat lozenge technique.
9. Caulis Sinomenii extract according to claim 8 and the Radix Sangusorbae extract application in preparing oral care product, it is characterized in that: the percentage by weight in throat lozenge raw material is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
10. Caulis Sinomenii extract according to claim 1 and the Radix Sangusorbae extract application in preparing oral care product, is characterized in that: the raw material of described Caulis Sinomenii extract and Radix Sangusorbae extract conduct analgesia, anastalsis in preparing chewing gum technique.
11. Caulis Sinomenii extracts according to claim 10 and the application of Radix Sangusorbae extract in preparing oral care product, it is characterized in that: the percentage by weight in chewing-gum material is 1.0% ~ 15.0% as compound Chinese medicine extract for described Caulis Sinomenii extract and Radix Sangusorbae extract, the former medicine of extract of described Caulis Sinomenii extract and described Radix Sangusorbae extract is than being 10:3; Described Caulis Sinomenii extract is Caulis Sinomenii ethanol extraction, and described Radix Sangusorbae extract is Radix Sanguisorbae ethanol extraction.
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| CN108478492A (en) * | 2018-05-23 | 2018-09-04 | 布伟年 | A kind of Radix Sangusorbae extract and the preparation method and application thereof |
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| CN108478492A (en) * | 2018-05-23 | 2018-09-04 | 布伟年 | A kind of Radix Sangusorbae extract and the preparation method and application thereof |
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| CN103536482B (en) | 2016-07-20 |
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