CN108478492A - A kind of Radix Sangusorbae extract and the preparation method and application thereof - Google Patents
A kind of Radix Sangusorbae extract and the preparation method and application thereof Download PDFInfo
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- CN108478492A CN108478492A CN201810505138.5A CN201810505138A CN108478492A CN 108478492 A CN108478492 A CN 108478492A CN 201810505138 A CN201810505138 A CN 201810505138A CN 108478492 A CN108478492 A CN 108478492A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The present invention relates to a kind of Radix Sangusorbae extracts and the preparation method and application thereof.The preparation method of Radix Sangusorbae extract of the present invention includes the following steps：(1) ethanol solution is added into garden burnet, is impregnated；(2) after impregnating, it is heated to boiling reflux, is extracted repeatedly at least once；(3) collection/merging extracting solution, the aqueous precipitation into extracting solution, gained sediment are Radix Sangusorbae extract；The present invention also provides the oral care products containing the Radix Sangusorbae extract.The present invention is using the active constituent in " wine dipper water heavy " method extraction garden burnet, and the independent water of concentration ratio of active ingredient carries in Radix Sangusorbae extract obtained or wine dipper is a lot of times high, and Radix Sangusorbae extract of the present invention has apparent anti-helicobacter pylori effect.
Description
Technical field
The present invention relates to a kind of extracts and the preparation method and application thereof, and in particular to a kind of Radix Sangusorbae extract and its preparation
Method and application.
Background technology
It is also to cause oral cavity and alimentary canal disease that helicobacter pylori Helicobacter pylori (abbreviation HP), which belong to micro- anaerobic bacteria,
" arch-criminal " of disease.It enters alimentary canal by oral cavity, has more than 90% duodenal ulcer and 80% or so gastric ulcer, slow
Property gastritis, indigestion are all related with it.Since the illness of initiation appears in stomach, detection target is just in usual " aiming " stomach
Helicobacter pylori, and ignore another important " depots "-- oral cavity of helicobacter pylori and pharyngeal in this way.
Though have currently on the market such as deep and remote spiral shell Sha star of anti-helicobacter pylori toothpaste, it is quiet and beautiful (health care medicine garden 6 phase P30 in 2015~
31；Deep and remote spiral shell Sha star, quiet and beautiful tooth paste product) etc. anti-HP toothpaste, addition content is mostly lactalbumin, probiotics, chitosan, bacteriolyze
The toothpaste of the synthesis such as enzyme and Chinese herbal medicine such as Radix Glycyrrhizae, radix scutellariae, Radix Isatidis, but do not form effective market brand and by vast consumption
Person is received.It is contemplated that this is related with the formula of synthetic and extraction process, the especially extraction process of Chinese herbal medicine.
To inhibiting the text of preliminary screening one (volume 14 the 9th of the Chinese combination of Chinese tradiational and Western medicine magazine 1994 of helicobacter pylori Chinese medicine
Phase：Wang Xulin etc.) it is with 1：1 200 kinds of Chinese herbal medicines of decocting concentration pair carry out bacteriostatic test, find wherein 38 kinds of Chinese herbal medicines to deep and remote
Helicobacter pylori has bacteriostasis efficacy.The existing extraction process to Chinese herbal medicine is mostly extracted with water, followed by direct finely ground powder.However, nothing
By by Chinese herbal medicine Aqueous extracts with 1：1 concentration concentrate or fine powder is added in toothpaste, due to active ingredient levels
Low, ideal effect is still not achieved in its general effect.Therefore, it cannot get market consumers in general approval, do not become brand effect
It answers.
The Chinese herbal medicine extraction process aging of the prior art, there are shortage innovative thinking, and outreach rate is insufficient, sale canal
The defects of road is unfavorable, while also affecting product popularity.
Invention content
A kind of preparation of Radix Sangusorbae extract is provided it is an object of the invention to overcome above-mentioned the deficiencies in the prior art place
Method is higher using active constituent content in Radix Sangusorbae extract made from this method.
Meanwhile the present invention also provides using Radix Sangusorbae extract and its application made from the above method.
To achieve the above object, the technical solution that the present invention takes is：
In a first aspect, the present invention provides a kind of preparation methods of Radix Sangusorbae extract comprising following steps：
(1) ethanol solution is added into garden burnet, is impregnated；
(2) after impregnating, it is heated to boiling reflux, is extracted repeatedly at least once；
(3) collection/merging extracting solution, the aqueous precipitation into extracting solution, gained sediment are Radix Sangusorbae extract.
In order to overcome the shortcoming of existing extraction process, inventor sets about formula adjustment and technological innovation, with pure plant
Object-garden burnet is raw material, using the active constituent in " wine dipper water is heavy " method extraction garden burnet.Being detected through Guangzhou inspection center proves, adopts
The Radix Sangusorbae extract made from the method for the present invention contains the active ingredient of tannic acid, gallic acid and radix sanguisorbae total saponin.It is prior
It is that the independent water of the concentration ratio of active ingredient carries in Radix Sangusorbae extract produced by the present invention or wine dipper is a lot of times high, if this product is with 100
Kilogram garden burnet only obtains 10 kilograms or so of extract.Concentration just because of active ingredient in Radix Sangusorbae extract of the present invention is special
Height, with apparent anti-helicobacter pylori effect.
In addition, it should be noted that, it when boiling refluxing extraction, can only extract once, can also extract repeatedly repeatedly, for example,
Carry out 3 times repeatedly extract when extraction effect more preferably.When being extracted repeatedly every time, new to the residue obtained middle addition of previous extraction
Ethanol solution extracts again.
The preferred embodiment of preparation method as Radix Sangusorbae extract of the present invention, in the step (1), ethyl alcohol is molten
The percent by volume of ethyl alcohol is 75%~95% in liquid；The weight ratio of ethanol solution and garden burnet is 2~5：1.
The preferred embodiment of preparation method as Radix Sangusorbae extract of the present invention, in the step (1), ethyl alcohol is molten
The percent by volume of ethyl alcohol is 95% in liquid；The weight ratio of ethanol solution and garden burnet is 3：1.Inventor inquires by numerous studies
It was found that under the specific extraction conditions, active constituent content is especially high in Radix Sangusorbae extract obtained, specifically, the garden burnet
Extract contains the component of following weight percentage：Tannic acid 5.60%, gallic acid 2.6% (belonging to triterpene substance) and garden burnet
Total saposins 22.8%.
The preferred embodiment of preparation method as Radix Sangusorbae extract of the present invention, in the step (1), immersion
Time is 1 hour.
The preferred embodiment of preparation method as Radix Sangusorbae extract of the present invention, in the step (1), to garden burnet
Before middle addition ethanol solution, first garden burnet is crushed.
The preferred embodiment of preparation method as Radix Sangusorbae extract of the present invention, in the step (3), water with carry
It is 2~5 to take the volume ratio of liquid：1；Preferably, in the step (3), the volume ratio of water and extracting solution is 3：1.
Second aspect, the present invention provides using Radix Sangusorbae extract made from the above method.The method of the present invention ground obtained
Elm extract contains the active ingredient of tannic acid, gallic acid and radix sanguisorbae total saponin, and these active ingredients are in Radix Sangusorbae extract
Content it is higher.
The third aspect, the present invention provides above-mentioned Radix Sangusorbae extracts in the oral care product for preparing anti-helicobacter pylori
Application.Radix Sangusorbae extract of the present invention has effects that cooling blood and hemostasis, removing toxic substances sore, and being used for oral care product can also press down
Helicobacter pylori processed, can prevent in this way helicobacter pylori from oral cavity enter alimentary canal and cause disease of digestive tract and be incremented by
The therapeutic efficiency of disease of digestive tract can also reduce the recurrence due to the microbial disease of digestive tract of helicobacter pylorus.
Radix Sangusorbae extract of the present invention is suitable for general oral care product, is particularly suitable for toothpaste and mouth cleaner etc..
Fourth aspect, the present invention provides a kind of oral care products of anti-helicobacter pylori, and it includes above-mentioned garden burnets to carry
Take object.
As the preferred embodiment of oral care product of the present invention, the oral care product is toothpaste, described
The weight percentage of Radix Sangusorbae extract is 0.6% or more in toothpaste；It is highly preferred that in the toothpaste Radix Sangusorbae extract weight
Percentage composition is 0.8%~1.0%.Most preferably, the weight percentage of Radix Sangusorbae extract is 0.8%% in the toothpaste.It grinds
Study carefully and shows that toothpaste has excellent anti-pylorus when the weight percentage of Radix Sangusorbae extract in toothpaste is 0.8%~1.0%
Helicobacter effect.
Compared with prior art, beneficial effects of the present invention are：The prior art carries with single water, wine dipper or pulverized powder etc.
Method extract garden burnet in active constituent it is the easiest and at low cost, but due in extract obtained activity component concentration contain
Measure low, its general effect does not reach requirement still.The present invention is using the active constituent in " wine dipper water is heavy " method extraction garden burnet, with same
Although medicinal material caused by extract amount it is few (general 100 per kilogram crude drug only extract 10 kilograms or so of pulvis), it is obtained
Radix Sangusorbae extract in the independent water of concentration ratio of active ingredient carry or high a lot of times of wine dipper, and can detect effective efficiency ingredient,
The toothpaste special of synthesis also has more satisfactory effect through crowd is on probation.
Description of the drawings
Fig. 1 is the result figure that Radix Sangusorbae extract of the present invention is used to inhibit helicobacter pylori；
Fig. 2 is the antibacterial result figure of toothpaste of the present invention.
Specific implementation mode
For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment to the present invention
It is described further.
Embodiment 1
A kind of embodiment of the preparation method of Radix Sangusorbae extract of the present invention, the preparation side of Radix Sangusorbae extract described in the present embodiment
Method is：
(1) first garden burnet is crushed, then ethanol solution is added into the garden burnet after crushing, impregnated 1 hour；Second in ethanol solution
The percent by volume of alcohol is 95%；The weight ratio of ethanol solution and garden burnet is 3：1；
(2) after impregnating, it is heated to boiling reflux, is extracted 3 times repeatedly；
(3) volume ratio of merging extracting solution, the aqueous precipitation into extracting solution, water and extracting solution is 3：1；Then it filters, receive
Collection sediment is simultaneously baked to, and obtains product, as Radix Sangusorbae extract.
Radix Sangusorbae extract made from the present embodiment contains the component of following weight percentage：Tannic acid 5.60%, nutgall
Acid 2.6% and radix sanguisorbae total saponin 22.8%.
The oral care product of the present embodiment, the oral care product are toothpaste, Radix Sangusorbae extract in the toothpaste
Weight percentage is 0.8%.
Embodiment 2
A kind of embodiment of the preparation method of Radix Sangusorbae extract of the present invention, the preparation side of Radix Sangusorbae extract described in the present embodiment
Method is：
(1) first garden burnet is crushed, then ethanol solution is added into the garden burnet after crushing, impregnated 1 hour；Second in ethanol solution
The percent by volume of alcohol is 85%；The weight ratio of ethanol solution and garden burnet is 2：1；
(2) after impregnating, it is heated to boiling reflux, is extracted 3 times repeatedly；
(3) volume ratio of merging extracting solution, the aqueous precipitation into extracting solution, water and extracting solution is 2：1；Then it filters, receive
Collection sediment is simultaneously baked to, and obtains product, as Radix Sangusorbae extract.
Radix Sangusorbae extract made from the present embodiment contains tannic acid, gallic acid and radix sanguisorbae total saponin.
The oral care product of the present embodiment, the oral care product are toothpaste, Radix Sangusorbae extract in the toothpaste
Weight percentage is 0.8%.
Embodiment 3
A kind of embodiment of the preparation method of Radix Sangusorbae extract of the present invention, the preparation side of Radix Sangusorbae extract described in the present embodiment
Method is：
(1) first garden burnet is crushed, then ethanol solution is added into the garden burnet after crushing, impregnated 1 hour；Second in ethanol solution
The percent by volume of alcohol is 75%；The weight ratio of ethanol solution and garden burnet is 5：1；
(2) after impregnating, it is heated to boiling reflux, is extracted 3 times repeatedly；
(3) volume ratio of merging extracting solution, the aqueous precipitation into extracting solution, water and extracting solution is 5：1；Then it filters, receive
Collection sediment is simultaneously baked to, and obtains product, as Radix Sangusorbae extract.
Radix Sangusorbae extract made from the present embodiment contains tannic acid, gallic acid and radix sanguisorbae total saponin.
The oral care product of the present embodiment, the oral care product are toothpaste, Radix Sangusorbae extract in the toothpaste
Weight percentage is 0.6%.
Embodiment 4
A kind of embodiment of the preparation method of Radix Sangusorbae extract of the present invention, the preparation side of Radix Sangusorbae extract described in the present embodiment
Method is the same as embodiment 1.
The oral care product of the present embodiment, the oral care product are toothpaste, Radix Sangusorbae extract in the toothpaste
Weight percentage is 1.0%.
Embodiment 5
The present embodiment demonstrates the fungistatic effect of Radix Sangusorbae extract of the present invention.The present embodiment is digested using Guangzhou Nanfang Hospital
Radix Sangusorbae extract made from the embodiment of the present invention 1 is used for blood plate (Blood Agar by the Helicobacter pylori Strains that internal medicine provides
) 024070 Plate (Guangdong tool note standard 20081685) culture medium carries out fungistatic effect detection by paper disk method, while with nutrition fine jade
Fat culture medium flat plate (Nutrient Agar II (Plate) 024089 (Guangdong fringe tool is for No. 20160346) culture medium.As a result such as Fig. 1
It is shown.Fig. 1 illustrates that Radix Sangusorbae extract of the present invention has helicobacter pylori more satisfactory fungistatic effect.
Embodiment 6
The present embodiment demonstrates the fungistatic effect of oral care product-toothpaste of the present invention.
1, bacteriostatic test
By Radix Sangusorbae extract made from the embodiment of the present invention 1, respectively with 1.0,0.8,0.6,0.4 grams not same amount be added toothpaste
Matrix is to 100 grams.Bacterium (helicobacter pylori, staphylococcus aureus, epidermis grape are carried out according to paper disk method described in embodiment 5
Coccus) bacteriostatic test, experimental result is as shown in table 1.
The result is that：The toothpaste that Radix Sangusorbae extract amount is 1.0g and 0.80g, which is added, ideal fungistatic effect, and causes inflammation
Common staphylococcus aureus is preferably 0.8g/% input amounts.So finally selecting inputs of the 0.8g/% as this toothpaste
Amount；It is that 0.6g toothpaste fungistatic effects below are undesirable that Radix Sangusorbae extract amount, which is added,.The toothpaste of different batches is detected, as a result
Identical, we finally select to 100 grams in the addition to toothpaste matrix of 0.8 gram of Radix Sangusorbae extract made from the embodiment of the present invention 1,
Toothpaste special is made, does bacteriostatic test according to 5 the method for embodiment, the results are shown in Figure 2.Fig. 2 shows toothpaste tool of the present invention
There is the effect of anti-inflammatory is antibacterial, removes Oral Helicobacter Pylori and golden Portugal, table Portugal.
Table 1
2, crowd tests and tries out
We are again with " helicobacter pylori quick detection test paper (eat medicine and supervise tool (standard) word 2014 the 2400019th in Guangdong) is to old
Teacher, student, government functionary, worker, enterpriser, driver, retired old man and the top class in a kindergarten of kindergarten children etc., nearly 1000 people surveys
Examination, total infection rate are 34%.
Prompt：Crowd's positive rate is higher：
※ often goes out to treat the person of having a dinner party, such as enterpriser with courtesy.
※ families enclose meal person.
There is infected with Helicobacter pylori in ※ families.
Account for about 75%~90%
Helicobacter pylori infection positive is prevented using toothpaste of the present invention, through selective examination, 100 uses 1~2
Branch toothpaste (90 grams every) person, as a result：The person of turning out cloudy 58, improve 29, it is 13 unchanged, efficient up to 87%.The result is said
Bright toothpaste of the present invention also has effects that removing Oral Helicobacter Pylori certain.It is to digestion to remove Oral Helicobacter Pylori
The morning of the diseases such as the road disease caused by helicobacter pylori infections such as indigestion, chronic gastritis, duodenal ulcer, gastric cancer
Phase prevents, prevents recurrence, improving in therapeutic effect with positive effect.
Embodiment 7
The present embodiment is respectively adopted that independent water carries, independent wine dipper and the method for the present invention prepare Radix Sangusorbae extract, and compare
The effect of its anti-helicobacter pylori.
The method that independent water carries is：Water is added into garden burnet, after immersion, is heated to boiling reflux, extracts repeatedly at least once；
Collection/merging extracting solution, obtains Radix Sangusorbae extract A after concentration.
Individually the method for wine dipper is：Ethanol solution is added into garden burnet, after immersion, be heated to boiling reflux, extract repeatedly to
It is few primary；Collection/merging extracting solution, obtains Radix Sangusorbae extract B after concentration.
The method of the present invention is：Ethanol solution is added into garden burnet, after immersion, is heated to boiling reflux, extracts at least one repeatedly
It is secondary；Collection/merging extracting solution, the aqueous precipitation into extracting solution, gained sediment are Radix Sangusorbae extract.
The Helicobacter pylori Strains provided using Guangzhou Nanfang Hospital GI Medicine, by Radix Sangusorbae extract A, Radix Sangusorbae extract
Radix Sangusorbae extract made from B and the method for the present invention is respectively used to blood plate (Blood Agar Plate) 024070, and (tool note in Guangdong is accurate
20081685) culture medium carries out fungistatic effect detection according to paper disk method shown in embodiment 5.The result shows that Radix Sangusorbae extract A and
The more independent water of antibacterial effect of Radix Sangusorbae extract B fungistatic effect unobvious, the Radix Sangusorbae extract that the method for the present invention obtains carries or individually
Radix Sangusorbae extract made from wine dipper is more preferable.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than is protected to the present invention
The limitation of range is protected, although being explained in detail to the present invention with reference to preferred embodiment, those skilled in the art should
Understand, technical scheme of the present invention can be modified or replaced equivalently, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of preparation method of Radix Sangusorbae extract, which is characterized in that include the following steps：
(1) ethanol solution is added into garden burnet, is impregnated；
(2) after impregnating, it is heated to boiling reflux, is extracted repeatedly at least once；
(3) collection/merging extracting solution, the aqueous precipitation into extracting solution, gained sediment are Radix Sangusorbae extract.
2. the preparation method of Radix Sangusorbae extract as described in claim 1, which is characterized in that in the step (1), ethanol solution
The percent by volume of middle ethyl alcohol is 75%~95%；The weight ratio of ethanol solution and garden burnet is 2~5：1.
3. the preparation method of Radix Sangusorbae extract as claimed in claim 2, which is characterized in that in the step (1), ethanol solution
The percent by volume of middle ethyl alcohol is 95%；The weight ratio of ethanol solution and garden burnet is 3：1.
4. the preparation method of Radix Sangusorbae extract as described in claim 1, which is characterized in that in the step (1), immersion when
Between be 1 hour.
5. the preparation method of Radix Sangusorbae extract as described in claim 1, which is characterized in that in the step (1), into garden burnet
Before ethanol solution is added, first garden burnet is crushed.
6. the preparation method of Radix Sangusorbae extract as described in claim 1, which is characterized in that in the step (3), water and extraction
The volume ratio of liquid is 2~5：1；Preferably, in the step (3), the volume ratio of water and extracting solution is 3：1.
7. using Radix Sangusorbae extract made from any one of claim 1~6 the method.
8. application of the Radix Sangusorbae extract as claimed in claim 7 in the oral care product for preparing anti-helicobacter pylori.
9. a kind of oral care product of anti-helicobacter pylori, which is characterized in that include Radix Sangusorbae extract described in claim 7.
10. oral care product as claimed in claim 9, which is characterized in that the oral care product is toothpaste, the tooth
The weight percentage of Radix Sangusorbae extract is 0.6% or more in cream；Preferably, in the toothpaste Radix Sangusorbae extract weight percent
Content is 0.8%~1.0%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111773278A (en) * | 2020-08-04 | 2020-10-16 | 中山大学 | Preparation method of sanguisorba officinalis extract and application of sanguisorba officinalis extract in preparation of anti-helicobacter pylori medicines |
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